ライフサイエンスコーパス: blunt

1 ho received a prepregnancy immunization, are blunted.

2 ies, but in neocapillaries, the response was blunted.

3 hear stress-stimulated eNOS activations were blunted.

4 HT2B receptor-mediated signaling was totally blunted.

5 tamine nonresponders had a lower mesor and a blunted 24-hour amplitude relative to baseline.

6 Isolated small bowel perforation following blunt abdominal trauma (BAT) is an uncommon situation wi

7 ctor computed tomography (CT) utilization in blunt abdominopelvic trauma (BAPT) over an 8-year period

8 or responses after inhibition of NO synthase blunted acetylcholine responses in KK and lean controls,

9 neural processing of negative affect may be blunted across drug and behavioral addictions independen

10 Twenty-four hours of fasting is known to blunt activation of the human NLRP3 inflammasome.

11 for rewards and positive prediction errors; blunted activation of the ventral striatum during reward

12 ive symptoms: reduced learning from rewards; blunted activation of the ventral striatum, midbrain, an

13 (LS)) neurons in animals exposed to ELS show blunted activity in response to social stimuli.

14 l subunit expression but not the result of a blunted activity-dependent intracellular Ca(2+) increase

15 dipocytes enhanced, whereas an miR-130 mimic blunted, adipogenic differentiation, suggesting that miR

16 Furthermore, Traf3ip2 gene deletion blunts adverse remodeling 12 weeks post-I/R, as evidence

17 ol recovery post-challenge was significantly blunted after chronic compared to single dosing with eit

18 All of these effects were blunted after rosiglitazone treatment.

19 iosynthesis, hyperphagia, and weight gain by blunting alpha-MSH production via CB1R-induced and extra

20 ed the hypothesis that the ability of ATP to blunt alpha1 -adrenergic vasoconstriction in resting ske

21 he ability of contracting skeletal muscle to blunt alpha1 -adrenergic vasoconstriction.

22 ATPase would not alter the ability of ATP to blunt alpha1 -adrenergic vasoconstriction.

23 Patients with depression show blunted amygdala hemodynamic activity to positive stimul

24 The data were separated into blunt and penetrating categories.

25 Recidivists with both initial blunt and penetrating injuries had higher rates of long-

26 has been extensively utilized and studied in blunt and penetrating trauma for the past 3 decades.

27 VTE are the same in patients who experienced blunt and penetrating trauma, the independent risk facto

28 in the mapping of the data with almost equal blunt and penetrating trauma.

29 ted with DNA, the humoral immune response is blunted and acquires features associated with T-bet+ B c

30 n contrast to wild-type, autophagic flux was blunted and associated with accumulation of residual bod

31 ostral increase in the glutamate measure was blunted and the caudal-to-rostral decline in the GABA me

32 us Pi loading caused phosphaturia, which was blunted and transient compared with that in intact rats.

33 semic range, thiazide responsiveness was not blunted, and genetic analyses did not show mutations in

34 ta T cells; deficiency in gammadelta T cells blunted Ang II-induced hypertension, vascular injury, an

35 antibody-induced gammadelta T-cell depletion blunted Ang II-induced SBP rise and endothelial dysfunct

36 ial enzyme in glutamine catabolism, markedly blunts angiogenesis.

37 hagocytic ligand exploited by tumor cells to blunt antibody effector functions by transmitting an inh

38 ease in circulating inflammatory chemokines, blunted antiviral gene signature within the pancreas, an

39 DR) pathway and SETD2 mutation impaired DDR, blunting apoptosis induced by cytotoxic chemotherapy.

40 de-major histocompatibility complexes (pMHC) blunted autoimmune responses by triggering the different

41 ventral striatum during reward anticipation; blunted autonomic responding for relevant stimuli; blunt

42 tive in killing cells, but their utility was blunted because they provoked immune reactions that inte

43 We provide novel evidence that 1) blunted binge-like ethanol consumption stemming from CRF

44 Sobetirome, a TH mimetic, also blunted bleomycin-induced lung fibrosis.

45 2 levels in vivo through lentiviral delivery blunted bleomycin-induced pulmonary fibrosis.

46 Nalmefene blunts BOLD response in the mesolimbic system during ant

47 and haemodynamic responses to mental stress, blunted BRS and inflammation may contribute to an increa

48 ia and eosinophil peroxidase deposition were blunted but not eliminated.

49 the helicase domain is required for binding blunt, but not 3' overhanging, termini.

50 viability and tumor formation was completely blunted by blockade of beta-adrenergic signaling in MCF-

51 The crack in the CG Cu was blunted by dislocation-slip mediated plastic deformation

52 This voltage dependence was blunted by electrogenic binding of intracellular K(+) an

53 tly from platelet count; this phenomenon was blunted by incubation with an inhibitor of Toll-like rec

54 EAU model prior to the onset of uveitis were blunted by oral SCFA administration.

55 ion with cytolytic and antiviral effects was blunted by PD-L1 expression on HCV-infected Huh7.5A2 cel

56 This antitumour response, however, is likely blunted by the presence of immunosuppressive pathways wi

57 ss of function or pharmacological inhibition blunts calcium responses to glucose in MBH neurons in vi

58 KEY POINTS: Patients with diabetes show a blunted cardiac inotropic response to beta-adrenergic st

59 d Irf5 expression, whereas knockdown of Irf5 blunted CB1R-induced secretion of inflammatory cytokines

60 at combining BH3 mimetics and gamitrinib-TPP blunted cellular proliferation in a synergistic manner b

61 Down-regulation of PKM2 by shRNA blunts cellular responses to shikonin but enhances the r

62 One thousand one hundred forty-six blunt cerebrovascular injury patients over 10 years.

63 We identified 1,146 blunt cerebrovascular injury patients; 54 (4.7%) experie

64 s after hospital arrival among patients with blunt cerebrovascular injury.

65 usion CC fractures are common in high-energy blunt chest trauma and often occur with multiple consecu

66 We propose that the blunted cholinergic excitability contributes to the func

67 ygosity of mouse Sdhb/Sdhc/Sdhd null alleles blunts chronic hypoxia-induced increases in hemoglobin l

68 omarker of cancer that is not subject to the blunting clonal selection effects that reduce the effica

69 lower ventral striatum dopamine activity and blunted cocaine self-administration.

70 Mdivi-1, a demonstrated fission inhibitor, blunts cocaine seeking and locomotor sensitization, whil

71 ates silenced TSGs, revealing their role for blunting colorectal cancer cell proliferation, invasion,

72 tor stimulation and noxious stimulation were blunted compared to WT mice.

73 netic or pharmacological inhibition of SRPK2 blunts de novo lipid synthesis, thereby suppressing cell

74 mpaired TDW maintenance in baseline wake and blunted delta power in SWS, reproducing, respectively, n

75 In our study blunt diaphragmatic rupture occurred in 6% of cases as c

76 Blunted dilatory responses to an NO donor and loss of my

77 We further showed that blunt dsRNA is locally unwound and threaded through the

78 Drosophila Dicer-2 alone and in complex with blunt dsRNA.

79 Dynamic blunt end contacts promote error correction and network

80 Our in vivo blunt-end cloning method and destabilization-domain-fuse

81 ase activity by X4-LIV and the efficiency of blunt-end ligation are determined by structural configur

82 leaves that target at its center to generate blunt-ended DNA fragments.

83 reference sequences and junction structure (blunt-ended junctions or junctions with insertions or mi

84 leases (EcoRV and HincII) that also generate blunt-ended products, and to a structurally distinct enz

85 n translocation along DNA is able to protect blunt-ended telomeres but is deficient in DNA repair.

86 We have previously suggested that blunt-ended telomeres in Arabidopsis thaliana are protec

87 Plants possess unusual blunt-ended telomeres that are unable to form t-loops or

88 This suggests that Ku physically sequesters blunt-ended telomeres within its DNA binding channel, sh

89 These results suggest that small blunt-ended tiles can be used as a platform to organize

90 a downstream A-rich tract (ENE+A) to form a blunt-ended triple helix composed of nine U*A-U triples

91 "Blunt-ended" tiles do not have single-stranded complemen

92 l dysgenesis with an abrupt termination of a blunt-ending spinal cord.

93 nalling in MNCs from RVH rats, partly due to blunted endoplasmic reticulum Ca(2+) buffering capacity.

94 nificant endothelial dysfunction measured by blunted endothelium-dependent vasorelaxation to acetylch

95 g-range ordering of DNA crossover tiles with blunt ends on lipid bilayers is investigated using atomi

96 those in the STZ group, consistent with the blunted epinephrine response.

97 artments of MNCs of RVH rats, and (2) that a blunted ER Ca(2+) buffering capacity contributes to the

98 documented that chronic progestin treatment blunted ER-mediated gene expression up to 2-fold at the

99 is study identifies that Parkin functions to blunt excessive CHOP to prevent maladaptive ER stress-in

100 cytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeost

101 TH did not blunt fibrosis in Ppargc1a- or Pink1-knockout mice, sugg

102 nt hippocampal neurogenesis is significantly blunted following IGF-1 infusion in knockout (RIT1 (-/-)

103 itotic drug arabinofuranosyl cytidine (AraC) blunted food intake, body weight gain, and adiposity.

104 onse for splanchnic flow and resistance were blunted for VVS compared with control after saline+PE, b

105 First, EGF-mediated activation of EGFR blunted fusion kinase inhibitor binding and restored fus

106 Importantly, LPA did not blunt glucagon-stimulated glucose production or PEPCK ex

107 nt of primary hepatocytes with exogenous LPA blunted glucagon-induced PEPCK expression and glucose pr

108 ogenous glutamate tone, which was not due to blunted glutamate transport activity, led to the sustain

109 us glutamate tone in RVH rats was not due to blunted glutamate transporter activity.

110 rgical intervention among a cohort of 11,770 blunt head injury patients.

111 ablation reduces fasting glucose levels and blunts hepatic gluconeogenesis without affecting systemi

112 This problem is rooted in a blunted hormonal responsiveness of the ageing uterus.

113 ses, including human cytomegalovirus (HCMV), blunt host antiviral defenses by limiting ISG expression

114 opment of therapeutic strategies that aim to blunt hypermetabolism appears warranted.

115 males, females have lower BP before age 60, blunted hypertensive response to angiotensin II, and a l

116 This blunted hypertrophic response was associated with a redu

117 cific loss of SRC-2 (SRC-2 CKO) results in a blunted hypertrophy accompanied by a rapid, progressive

118 Mechanistically, the HIF1alpha/2alpha dKO blunted hypoxia-induced activation of Notch signaling, a

119 ession and secretion to levels sufficient to blunt in vitro tube formation and proliferation of endot

120 Of interest, ischemic AMPK activation was blunted in aged hearts compared with young hearts (P < 0

121 This effect was blunted in beta-cells of betaGC-A-KO mice, and the maxim

122 and APD reductions during deoxygenation were blunted in both LWHs and LANG hearts.

123 type cells upon biotin withdrawal which was blunted in cell lacking Pyc.

124 vascular occlusion in vivo was significantly blunted in ck2beta(-/-) mice, accompanied by a slight pr

125 ity of NPY on C-Fos induction in the PVH was blunted in conditions of insulin deficiency and fasting,

126 Insulin-mediated vasodilation was blunted in ECSHIP2(Delta/+) mice, as was aortic nitric o

127 neralocorticoid receptor expression was also blunted in human cells treated with plasma from septic p

128 e wild-type controls, the effect was largely blunted in Il17a (-/-) mice.

129 ine-induced hyperphagia and weight gain were blunted in mice lacking the serotonin 2C receptor (HTR2C

130 cts and activation of signaling in dMSNs are blunted in mice with the constitutive knockout of D2R (D

131 and the underlying apamin-sensitive IAHP are blunted in MNCs from HF rats.

132 nd the underlying apamin-sensitive IAHP were blunted in MNCs from HF rats.

133 tivation of mTOR signaling was significantly blunted in muscles from both inducible and skeletal musc

134 horylation of ryanodine receptors, which was blunted in Nod1(-/-)-PMI cardiomyocytes.

135 Venular dilatation to acetylcholine was blunted in OZR vs. LZR due to increased oxidant stress-b

136 peraemic responses to lower frequencies were blunted in OZR, but responses at 3 Hz were similar betwe

137 ough Angiotensin II-induced hypertension was blunted in PAI-1(-/-) mice, cardiac hypertrophy was acce

138 dent prolongation of heart rate increase was blunted in PDE4D but not in wildtype or PDE4B knockout m

139 IA in sham rats, but this effect was largely blunted in RVH rats.

140 , including lipophagy, but these effects are blunted in SHP-null mice or LSD1-depleted mice.

141 AngII-induced hypertension was blunted in Sphk1(-/-) mice (systolic BP 167 +/- 4.2 vs.

142 e spleen and perivascular adipose tissue was blunted in Tcrdelta(-/-) mice (P<0.01).

143 developmental pruning of these cartridges is blunted in the illness.

144 te of glucose appearance during exercise was blunted in the KO mice because of a diminished glycogeno

145 II-induced hypertension, which, however, was blunted in Tie2-CreNox2KO mice, along with preservation

146 sponse to intracarotid glucose injection are blunted in TRPC3-deficient mice.

147 sed in cholestatic WT mice and significantly blunted in TRPC5 KO mice.

148 Blunting in key frontal, cingulate, and striatal areas w

149 Presumably due to a blunted increase in the concentration of cytosolic Ca(2+

150 nsmembrane conductance regulator (CFTR) have blunted induction of PI3K/AKT signaling in response to T

151 ype and constitutively active SOD2 similarly blunted inflammasome assembly and activation, effects th

152 ulting in erratic intravascular dynamics and blunted inflammation.

153 At both 3 and 6 months, Mmp28(-/-) mice had blunted inflammatory responses more closely resembling n

154 A somatostatin receptor 5 antagonist, which blunts inhibition of GLP-1 release, and agonists for TGR

155 ing cause of permanent visual loss following blunt injury to the head.

156 d a median ISS of 17 with 72% suffering from blunt injury.

157 nse to the glucose challenge, while slightly blunting insulin and C-peptide peaks.

158 S, endothelial FcgammaRIIB activation by CRP blunts insulin delivery to skeletal muscle to cause insu

159 Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK activation, alterations in substra

160 V replication, and that IE1 is sufficient to blunt ISGylation in response to dsDNA sensing in uninfec

161 tration of a lactate dehydrogenase inhibitor blunted lactate production in germ-free mice, suggesting

162 impaired D2R internalization in SZ leads to blunted late-phase displacement, or a faster return to b

163 ay explain the increase in passive force and blunted length-dependent activation of myofilaments in P

164 Deletion of Cysltr1 blunted LTC4-induced ILC2 expansion and eosinophilia but

165 phagy of p62-enriched protein aggregates and blunt macrophage apoptosis and pro-inflammatory IL-1beta

166 and Injury Severity Score 22 (13-34), 73.5% blunt mechanism, 47% severe TBI, 20.5% massively transfu

167 ive small molecule PRMT5 inhibitors severely blunted memory Th expansion, with preferential suppressi

168 and Ang II-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.

169 onstitution of mitochondrial-targeted GCN5L1 blunts mitochondrial ROS, ERK activation and increases F

170 alpha1 or pharmacological inhibition of AMPK blunted monocyte-to-macrophage differentiation and promo

171 Taken together, our results show how blunting MYC oncogene addiction can leverage cancer cell

172 d autonomic responding for relevant stimuli; blunted neural activation for aversive outcomes and aver

173 In particular, various studies have shown blunted neural and behavioral responses to the experienc

174 rols, youth with IGD exhibited significantly blunted neural responses within distributed subcortical

175 R7BP expression blunted neurite formation evoked by serum starvation by

176 d grafts are lost upon PT-Cy administration, blunting NK cell alloreactivity in this transplantation

177 Most drugs of abuse lead to a general blunting of dopamine release in the chronic phase of dep

178 be mediated, in part, through SIRT3-directed blunting of NLRP3 inflammasome assembly and activation.

179 urrent and/or antecedent hypoglycemia causes blunting of protective counterregulatory responses, know

180 ent stress in mice resulted in a significant blunting of the corticosterone response during pregnancy

181 ies, the high ACE women showed a significant blunting of the HPA response.

182 Blunting of the infant pertussis vaccine response was de

183 uals with APOC3 knocked out displayed marked blunting of the usual post-prandial rise in plasma trigl

184 st prominently, and, when silenced, observed blunting of the ventilatory response to inhaled CO2Tac1-

185 en August 1, 2011, and January 1, 2015, with blunt or penetrating injuries.

186 of venous thromboembolism (VTE) varies with blunt or penetrating trauma.

187 deferred healing-related edematous wave was blunted or absent in pigs undergoing preconditioning or

188 Additionally, we observed ablation, blunting, or distortion of microvilli in infected epithe

189 AC-induced increase in cytosolic calcium is blunted owing to mitochondrial calcium sequestration, an

190 nic enzyme expression and glucose output and blunts palmitate-induced hepatocyte fat deposition in an

191 This blunting partially mediated group differences in reactio

192 m isolated adipocytes of gp130 knockout mice blunted Pcsk1 expression and GLP-1 release from GLUTag c

193 However, ATP maintained the ability to blunt PE-mediated vasoconstriction (PE-mediated DeltaFVC

194 rminal center T follicular helper cells, and blunted PE-specific germinal center B cell responses.

195 less activated microglia in the brain and a blunted peripheral proinflammatory response compared wit

196 tic evidence that miR-17-92 iEC-KO mice have blunted physiological retinal angiogenesis during develo

197 PAK1 and PAK2 in IEC-18 and Swiss 3T3 cells blunted PKD1 phosphorylation at Ser(203), 3) phosphoryla

198 Pharmacologic inhibitors of ERK5 blunted platelet activation and aggregation in response

199 growing dynamic microtubules to microtubule blunt plus-ends.

200 gy depletion activates AMPK (Threonine 172), blunting protein synthesis and mTOR signaling, culminati

201 Mutations disrupting this signal blunted proteolytic degradation downstream of E3 ubiquit

202 the conversion of androgens to estrogen and blunts pulmonary hypertension in animals, but its effica

203 Importantly, we identified blunted relationships between trialwise variation in rea

204 signaling quiescence, the second response is blunted relative to the first response, whereas longer i

205 on, chronically inflamed Rab27DKO mice had a blunted response to bacterial LPS, resembling endotoxin

206 In vivo, good prognosis animals had a blunted response to dobutamine with respect to stroke vo

207 sarcomeres and sarcoplasmic reticulum and a blunted response to isoprenaline.

208 piratory phenotype of PWS (central apnea and blunted response to respiratory challenges).

209 shown that heightened nicotine cravings and blunted response to stress are independent and significa

210 ponse to furosemide and exhibited a severely blunted response to thiazide.

211 The blunted response was not due to changes in eNMDAR expres

212 how a statin intervention could alter these blunted responses.

213 g endophenotypes of depression: neuroticism, blunted reward learning, and cognitive control deficits.

214 However, KRIT1 depletion blunted ROS production in response to TNF-alpha.

215 Further, Il17a(-/-)f(-/-) mice showed blunted S. aureus-induced inflammation.

216 Finally, blunted sensitivity to ambiguity also predicted a greate

217 gulated patterns of sleep and wakefulness by blunting serotonergic signaling in the lateral hypothala

218 TQIP database study including patients with blunt severe TBI (AIS >/= 3), those that received LMWH o

219 alanine, based on the key residues in Deg1, blunted SM cholesterol-mediated turnover.

220 colysis and fatty acid synthesis in juvenile blunt snout bream.

221 Though vaccines and current therapeutics can blunt some of the perilous impact of this viral infectio

222 Third, a blunted subjective response to peer acceptance (ie, neut

223 wing long-term ethanol exposure, rats showed blunted task-related recruitment of vmPFC glycine and se

224 tes the SCF(beta-TrCP) E3-ligase activity in blunting Taz proteasomal degradation.

225 Blunt termini promote processive cleavage, while 3' over

226 reast cancer patients and is associated with blunted Th17 differentiation.

227 IFN-I-induced markers on DCs and effectively blunted Th2 development.

228 at PTCs were more likely to be injured by a blunt than penetrating injury mechanism (91.4%) compared

229 BGB324 targets the tumor-immune interface to blunt the aggressive traits of PDAC cells in vitro and e

230 in the P2X7 receptor that can be targeted to blunt the development of morphine analgesic tolerance, w

231 ergy storage (high-fat diet-induced obesity) blunt the effect of leptin.

232 Angiotensin receptor blocker treatment may blunt the harm associated with high levels of AT1RaAb.

233 have developed a new strategy to temporarily blunt the reticuloendothelial system uptake of nanodrugs

234 hyl-l-cysteine failed to exert protection or blunt the rise in ubiquitinated proteins.

235 ntibodies against viral surface proteins can blunt the spread of viral infection by coating viral par

236 9-expressing cells, and in vivo loss of Sox9 blunted the cardiac fibrotic response on ischemic injury

237 Lack of periostin expression also blunted the de novo renal expression of integrin-beta3 a

238 In addition, antiprogestins RU 38486 blunted the denervation-induced decrease in mRNA levels

239 oth IL-5 neutralization and STAT5 inhibition blunted the effects of PD-L2 mAb blockade on B-1 cells.

240 nociceptive sensory afferents significantly blunted the evoked visceromotor response to bladder dist

241 because N(G)-monomethyl-l-arginine markedly blunted the flow response to obestatin in both groups (b

242 in pFRG/RTN triggered local PGE2 release and blunted the hypercapnic response.

243 or pharmacological blockade of microRNA-146a blunted the hypertrophic response and attenuated cardiac

244 dent inhibitory somatodendritic currents and blunted the impact of D2R activation on spontaneous acti

245 el, percutaneous pericardial resection again blunted the increase in LV end-diastolic pressure second

246 preparations of normal dogs, pericardiotomy blunted the increase in LV end-diastolic pressure with s

247 findings for human NLRP3, prolonged fasting blunted the inflammasome in wild-type mice but not in SI

248 ion, reduced nuclear SREBP-1c abundance, and blunted the lipogenic response to feeding, LXR agonist t

249 Deletion of FKBP51 blunted the PAR- or lithium-induced increase in pGSK3bet

250 ciation of PKD1 from the plasma membrane and blunted the phosphorylation of nuclear targets, includin

251 We found that deletion of PiT1 or PiT2 blunted the Pi-dependent ERK1/2-mediated phosphorylation

252 Furthermore, genetic deletion of MR in SMCs blunted the production of Rac1-GTP after IR.

253 Remarkably, the loss of SIRT2 blunted the response of AMPK to metformin treatment in m

254 Furthermore, intra-VTA oleate blunted the rewarding effects of high-fat/sugar food in

255 i] perturbation of Tac1-Pet1 neuron activity blunted the ventilatory response of the respiratory CO2

256 are released is typically immunosuppressed, blunting the ability to initiate immune responses.

257 esented the highest cytoprotective effect by blunting the apoptosis process.

258 ution and effective signaling of STING, thus blunting the transcription of type I IFNs.

259 below 10%) effectiveness of interventions in blunting the ZIKV transmission from symptomatic cases to

260 This approach blunts the contribution to immunity of major subsets of

261 On one hand, mTOR inhibition blunts the induction of cyclin-dependent kinase (CDK) in

262 Irisin depletion from serum blunts the induction of oxygen consumption rate observed

263 on interrupts behavior, and blocking the STN blunts the interruptive effect of surprise.

264 zes to the nucleus, and its loss-of-function blunts the molecular rhythms and output rhythms of the s

265 receptors in T lymphocytes and myeloid cells blunts the polarization of these cells toward proinflamm

266 sis and disruption of its binding to Galphai blunts the pro-metastatic behavior of cancer cells.

267 On the other hand, inhibition of mTOR blunts the senescence-associated secretory phenotype (SA

268 lymphatic trafficking of dermal DCs but also blunted their capacity to prime CD8(+) T cell responses

269 Polyphenol-rich foods may blunt these effects when they are incorporated into a hi

270 nses to cocaine, while expression in D2-MSNs blunted these behaviors.

271 the agonists; Toll-like receptor 4 inhibitor blunted this effect.

272 dolescents younger than 18 years treated for blunt torso trauma at the University of California, Davi

273 y stable children treated in an ED following blunt torso trauma, the use of FAST compared with standa

274 In 813 patients with blunt trauma (mean [SD] age, 47 [19] years) and 324 pati

275 ve observational study of 1668 patients with blunt trauma aged 18 years and older who underwent cervi

276 y computed tomographic (CT) examinations for blunt trauma and to evaluate distribution of CC fracture

277 In the blunt trauma group, more patients with VTE than without

278 All whole-body CT examinations for blunt trauma over 36 months were reviewed retrospectivel

279 Severely injured human blunt trauma patients (n = 472, average injury severity

280 METHODS AND Blunt trauma patients admitted to the trauma intensive c

281 016048547) included adult (age >/= 16 years) blunt trauma patients admitted with TBI.

282 The NEXUS Head CT DI reliably identifies blunt trauma patients who require head CT imaging and co

283 One hundred thirty-five adult blunt trauma patients with hemorrhagic shock who survive

284 in computed tomographic (CT) head imaging in blunt trauma patients.

285 ll (104 of 1137) and similar between groups (blunt trauma, 9% [n = 73] vs penetrating trauma, 9.6% [n

286 ors of chronic critical illness after severe blunt trauma.

287 Targeting c-Rel blunts Treg cell immunosuppressive activity in the tumor

288 hibition of IL-6 signaling, is sufficient to blunt tumor initiation and impair tumor progression with

289 flammatory processes to help clear tumors by blunting tumor neovascularization and restoring immunosu

290 ng stromal LDH-A as an effective strategy to blunt tumoral immune escape.

291 t, which we postulate instead arises through blunted up-regulation of CD147 expression and subsequent

292 neogenic targets, and the effects of YAP are blunted upon its knockdown.

293 NRP2 also blunted upregulation of an EGFR "rescue" pathway induced

294 Furthermore, blunted vascular mineralocorticoid receptor expression m

295 al atrophy, and enhanced vasoconstrictor and blunted vasodilatory pathways.

296 For the MIDT, there was evidence of blunted ventral striatal response to reward in the poly-

297 pt1, Aox, Lcad, Ehhadh, Hsd10 and Acaa2, and blunted VLDL export with decreased expression of Mttp an

298 Differences in risk factors for VTE with blunt vs penetrating trauma.

299 Moreover, cardiomyocyte hypertrophy is blunted with cardiac fibroblast-specific loss of beta-ca

300 physiological stimulation of aldosterone was blunted with older age (beta=-4.6 ng/dL per 10 years, P<