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1 ced STEC-induced histological damage (villus blunting).
2 ing of attenuation of the mucosa with villus blunting.
3 uced histopathological damage such as villus blunting.
4 epithelial cells, crypt expansion and villus blunting.
5 helial lymphocytes, eosinophils, and villous blunting.
6 ly, DcR1 attenuates temozolomide efficacy by blunting activation of the Fas receptor pathway in p53(+
8 iosynthesis, hyperphagia, and weight gain by blunting alpha-MSH production via CB1R-induced and extra
9 the host by diminishing bacterial burden and blunting an otherwise overwhelming inflammatory response
11 ethal intestinal pathology, including villus blunting and death of intestinal crypts, and loss of lip
13 sis of epithelium and lamina propria, villus blunting and fusion, and transmural edema and hemorrhage
15 wild-type mouse podocyte and that there were blunting and widening of the minor (foot) processes in a
16 h as social withdrawal, apathy and emotional blunting) and other psychopathological symptoms (such as
17 asia, muscularis propria hypertrophy, villus blunting, and expression of inflammatory and remodeling
23 lly administered FGF2 is highly effective at blunting anxiety behavior, specifically in high-anxiety
24 DR) pathway and SETD2 mutation impaired DDR, blunting apoptosis induced by cytotoxic chemotherapy.
27 se in cardiomyocyte autophagic activity, and blunting autophagy increased the rate of aggregate accum
28 that died as well as survivors, reflecting a blunting but not complete inhibition of the inflammatory
30 ing Ca(2+) increases by 67 +/- 16%) and D2R (blunting Ca(2+) decrease by 72 +/- 17%) neurons in most
31 ttenuated responses to acute cocaine in D1R (blunting Ca(2+) increases by 67 +/- 16%) and D2R (blunti
32 ificantly improved collagen quality, thereby blunting cardiac dilatation and dysfunction after MI.
34 then kept in subsequent criteria: emotional blunting, changes in volition, and changes in social lif
36 omarker of cancer that is not subject to the blunting clonal selection effects that reduce the effica
37 that the effects of CREB over expression on blunting cocaine reward could be, at least in part, attr
38 ates silenced TSGs, revealing their role for blunting colorectal cancer cell proliferation, invasion,
39 the CTBs, which involve alternated crack tip blunting, crack deflection, twinning/detwinning and slip
40 that glycine prevents reactive arthritis by blunting cytokine release from macrophages by increasing
42 that loss of Bin1 may promote malignancy by blunting death penalties associated with oncogene activa
43 pe channel via transcriptional interference, blunting deleterious effects of mutant L-type channel ov
45 teric) adipocytes may be a novel approach to blunting detrimental fat-liver crosstalk in obesity.
46 We conclude that exogenous ATP is capable of blunting direct postjunctional alpha-adrenergic vasocons
47 ether, these results suggested that reagents blunting donor T-cell RAR signaling may possess therapeu
53 terregulatory responses are sensitive to the blunting effects of even short-duration prior hypoglycem
54 d assays at low levels of ADAMTS13 activity, blunting efforts to establish genotype-phenotype correla
57 PARdelta/beta phenocopies CD36 deficiency in blunting fasting induction of muscle FoxO1 and PDK4 in v
58 hanol may disrupt postsynaptic maturation by blunting feedback signaling through immature GABAARs.
60 Gi subfamily to decrease intracellular cAMP, blunting glucose-stimulated insulin secretion (GSIS).
61 te to further T cell recruitment and that by blunting glutamate-mediated platelet activation, graft s
62 f intestinal epithelial architecture (villus blunting, goblet cell hyperplasia, and increased epithel
65 effects on T-cell activation, with IFN-beta blunting IFN-gamma-induced upregulation of epithelial ce
69 ]; SCZ: +1.8% [11%]; P = .01); a generalized blunting in dopamine release in SCZ involving most extra
70 n gluconeogenesis, bile diversions promote a blunting in hepatic glucose production, whereas intestin
71 kinase activity (P < 0.05 vs. control), 2) a blunting in insulin-stimulated IRS-1 tyrosine phosphoryl
73 findings in knockout mice, we propose that a blunting in P2Y2 receptor expression or activity is a ne
74 to moderate to severe villous shortening and blunting in the duodenum and jejunum of WT-PEC-inoculate
75 on errors in the midbrain, and the degree of blunting in the encoding of prediction errors in the ins
78 ention of TonEBP, resulting in a substantial blunting in transcription of important osmotic stress re
81 duodenal and colonic mucosa including villus blunting, increased lamina propria and intraepithelial l
82 channel and hyperpolarizes the cell membrane-blunting increases in [Ca2+]i that are required for tran
86 sed the frequency of Ca(2+) pulsars, whereas blunting IP(3) production, blocking IP(3)Rs, or depletin
88 BA A pathways can play a significant role in blunting key autonomous nervous system, neuroendocrine,
89 xcess FAs toward TAG storage in LDs, thereby blunting lipotoxicity-associated insulin resistance.
90 ical support for the notion that exogenously blunting M1 signaling (pharmacologically or with cortica
93 ered in these symptoms but also in affective blunting, motor retardation, and passive or apathetic so
94 Antitumor activity was not diminished by blunting murine natural killer activity, suggesting that
96 genescell envelope proteinase (SpyCEP), thus blunting neutrophil-mediated killing and enabling ingres
97 d grafts are lost upon PT-Cy administration, blunting NK cell alloreactivity in this transplantation
98 re needed to address whether the physiologic blunting observed here might be a useful correlate of ap
99 t apical dendritic atrophy might result in a blunting of 5-HT- and hypocretin-induced excitatory resp
103 low CYP11B1/CYP11B2 selectivity resulted in blunting of adrenocorticotropic hormone-stimulated corti
104 nization and memory; personality change with blunting of affect or disinhibited and inappropriate beh
106 reased CaMKII activity may contribute to the blunting of agonist-evoked arrhythmias in the atrial myo
107 .3 mmol/l resulted in additional significant blunting of all major neuroendocrine and metabolic respo
108 During hypoglycemia on day 2, DHEA prevented blunting of all neuroendocrine, autonomic nervous system
109 the forearm and leg, it does not appear that blunting of alpha-adrenergic responsiveness is the cause
115 rmal baroreflex function as indicated by the blunting of baroreflex sensitivity (BRS) following the a
117 vity of calcium-dependent force development, blunting of both PKA-dependent calcium desensitization,
119 ted the hypothesis that (1) aging involves a blunting of cAMP diurnal rhythmicity in the SCN; (2) adm
120 Greater BMI was associated with generalised blunting of cardiovascular (HR:beta = -0.50 bpm x unit(-
121 f cytokine-mediated Akt/FOXO inhibition, and blunting of cathepsin-L-mediated lysosomal protein break
122 reactivity to stress, leading to a relative blunting of cortisol stress reactivity in G allele genot
125 mically tractable approach for the effective blunting of cytokine storm, leading to the improvement o
127 eading to accumulation of exogenous 5-HT and blunting of endogenous 5-HT axonal outgrowth specificall
128 r restricted protein, of the ewe can produce blunting of endothelial-dependent and -independent relax
129 tecedent hypoglycemia results in significant blunting of essential neuroendocrine (glucagon, insulin,
130 anxiety disorders and is associated with the blunting of GH in those children relative to that of com
131 by Homer proteins, and it was found that the blunting of group I mGluR-induced glutamate release and
134 treated diabetic mice was associated with a blunting of hyperglycemia-induced monocytosis and reduce
135 , endotoxin tolerance also can lead to fatal blunting of immunological responses to subsequent infect
137 nucleus of the stria terminalis (BSTLD), the blunting of ingestion reward by naltrexone may result fr
138 mechanisms, including central sensitization, blunting of inhibitory pain pathways, alterations in neu
141 e, while high-fat feeding resulted in a full blunting of insulin-stimulated glucose transport in the
142 estruction of the epithelial barrier, severe blunting of intestinal villi, and recruitment and activa
143 oderate hypoglycemia can produce significant blunting of key neuroendocrine and metabolic counterregu
145 ments demonstrated that the hypoxia-mediated blunting of M-CPT I gene expression occurs at the transc
147 coupling helps to explain the age-associated blunting of maximal exercise EF, and its underlying mech
149 lenged through FcepsilonRI had a significant blunting of mediator release compared with nontreated ce
152 Lower postprandial LGD in obese subjects and blunting of MPS responses to amino acids suggest that ob
153 fied troponin confirmed that this cTnC-G159D blunting of myofilament desensitization results from alt
154 le inactivation of linear ubiquitination and blunting of NF-kappaB nuclear translocation in response
155 be mediated, in part, through SIRT3-directed blunting of NLRP3 inflammasome assembly and activation.
157 in myogenic tone are two further findings: a blunting of paxilline-induced increase in myogenic tone
158 egulated by PPARalpha except for appreciable blunting of peroxisome proliferative response as compare
161 ing day 1 euglycemia resulted in significant blunting of plasma epinephrine, norepinephrine, glucagon
162 ects, patients with bulimia nervosa showed a blunting of postprandial cholecystokinin release, partic
163 nges with tumor burden included the complete blunting of postprandial MPS (0.038 +/- 0.004%/h in the
164 of procollagen alpha1(I) messenger RNA, and blunting of profibrogenic activities of transforming gro
165 urrent and/or antecedent hypoglycemia causes blunting of protective counterregulatory responses, know
167 zolid toxicity that needs to be confirmed is blunting of reactive mitochondrial biogenesis and unfold
169 DNA damage, synergistic tumor cytotoxicity, blunting of self-renewal, and strong anti-tumor response
170 (increased onset and deactivation rates) and blunting of sensitivity also engendered by RGS protein a
172 and defective regeneration with significant blunting of signal transducer-and-activator of transcrip
173 weight early pubertal girls have significant blunting of sleep-related LH production, which is the fi
174 ex in the brain at rest (t = 5.63) predicted blunting of smoking cue responses in the medial orbitofr
175 nding, and suggest that inflammation-induced blunting of SN responses to hippocampal novelty signals
176 als, we observed a pronounced and persistent blunting of stress-induced DA release in the right PFC b
177 and substance dependence showed significant blunting of striatal DA release, in contrast to what has
178 of antecedent hypoglycemia produced specific blunting of subsequent counterregulatory responses.
179 cked by DA receptor antagonism, CB1-mediated blunting of suprathreshold fear memory was rescued by in
180 present results suggest that hypoxia-induced blunting of sympathetic vasoconstriction in skeletal mus
182 n in intake was accompanied by a conditioned blunting of the accumbens dopamine response to the sacch
184 ailure of D(5)R to internalize and bind GTP, blunting of the agonist-induced increase in cAMP product
188 odeoxyuridine uptake, which was confirmed by blunting of the cell growth rate of infected cells compa
190 ent stress in mice resulted in a significant blunting of the corticosterone response during pregnancy
195 l of the host immune response and indicate a blunting of the immune mechanism in humans and animals.
197 ignificance of which is reflected by similar blunting of the in vivo bone resorption marker tartrate-
198 his protection correlated with a significant blunting of the induction of PAI-1 caused by ethanol/LPS
200 y peritoneal CO2 insufflation contributes to blunting of the local inflammatory response during lapar
201 ic excitability of BLA pyramidal cells and a blunting of the medium component of the afterhyperpolari
203 roved resuscitation may be attributable to a blunting of the nuclear factor-kappa B and interleukin-6
204 ntial termination is unlikely) resulted in a blunting of the odds ratios; however, a trend for parity
206 creasing renin response to insulin predicted blunting of the renal vasodilator response to insulin in
207 om recent large clinical trials confirm that blunting of the renin-angiotensin system through either
211 uals with APOC3 knocked out displayed marked blunting of the usual post-prandial rise in plasma trigl
212 st prominently, and, when silenced, observed blunting of the ventilatory response to inhaled CO2Tac1-
214 ontinuous LPS was reflected in a significant blunting of transcription factor activation and cytokine
215 ron microscopy confirmed mild shortening and blunting of villi in the duodenum and jejunum of the TC-
216 dothelial cell hypertrophy of blood vessels, blunting of villi, and lacteal dilatation with lymphocyt
217 , and recent therapeutic approaches aimed at blunting or reverting detrimental protumorigenic phenoty
220 modified our protocol to include a stage of blunting our intermediate products with T4 DNA polymeras
221 .3 mmol/l resulted in additional significant blunting (P < 0.01) of pancreatic polypeptide, norepinep
222 ing day 1 euglycemia resulted in significant blunting (P < 0.05) of ANS (epinephrine, norepinephrine,
223 Antecedent hypoglycemia produced widespread blunting (P < 0.05) of neuroendocrine, ANS, and metaboli
227 lso normalized abnormal mechanosensing while blunting progressive chamber hypertrophy in Duchenne mus
228 gy depletion activates AMPK (Threonine 172), blunting protein synthesis and mTOR signaling, culminati
229 e alcohol treatment inhibits the HPG axis by blunting release of LH-releasing hormone (LHRH) in femal
231 o, vulnerability to ethanol-induced receptor blunting requires elements of an intact brain environmen
232 Further, the mechanism for adrenocortical blunting resides at the level of the adrenal cortex rath
235 gulated patterns of sleep and wakefulness by blunting serotonergic signaling in the lateral hypothala
236 epsin-induced cleavage of SIRT 1 in EPCs and blunting SIPS and apoptotic cell death induced by releva
238 ced hypercortisolemia may be responsible for blunting subsequent sympathoadrenal responses to hypogly
239 is that nitric oxide (NO) is responsible for blunting sympathetic alpha-adrenergic vasoconstriction i
240 We studied the role of nitric oxide (NO) in blunting sympathetically evoked muscle vasoconstriction
245 ngs demonstrate a quality control checkpoint blunting terminal PC differentiation by eliminating thos
247 e to increase the uptake of avid substrates, blunting the ability of investigators to measure clinica
248 ainst functional gp120/gp41 trimers, thereby blunting the ability of particles to elicit neutralizing
250 elial system, suppressing erythropoiesis and blunting the activity of erythropoiesis stimulating agen
251 improved carbohydrate and lipid metabolism, blunting the AEA-induced increase in gene expression of
254 ty of MAs to alpha1AR vasoconstriction while blunting the attenuation of sympathetic vasoconstriction
255 e micropores prevents further drug delivery, blunting the clinical utility of this unique transdermal
260 ffector cells, but suppression was dominant, blunting the expansion of naive tumor-specific T cells a
261 alysis suggests that FGF21 acts primarily by blunting the growth hormone/insulin-like growth factor-1
264 fic humoral and cellular immune responses in blunting the immunogenicity of a rAd5-Env vaccine in mic
265 eases in luminal diameter have the effect of blunting the impact of flow velocity on microvillous she
266 ffects under these conditions, significantly blunting the increase in all these parameters caused by
267 PA1 protected mice from peritoneal fibrosis, blunting the increases in peritoneal collagen by 65.4 an
272 ocytes via a STAT5-dependent pathway, and by blunting the proinflammatory effects of IL-17 on its tar
274 tly inhibited PVM-elicited cytokine storm by blunting the PVM-specific CD8(+) T cell response, result
276 f BAPTA over equal concentrations of EGTA in blunting the regulation of the cyclase by capacitative C
277 ilarly, and (2) TNF-alpha decreases force by blunting the response of muscle myofilaments to calcium
278 in schizophrenia by disrupting learning and blunting the salience of rewarding events, and contribut
280 e limited role during secondary listeriosis, blunting the strength of the delayed-type hypersensitivi
281 ine, can be used as a pharmacologic means of blunting the stress response throughout the perioperativ
282 effects on perioperative pulmonary function, blunting the surgical stress response and improved analg
283 ssociated with a nonsignificant trend toward blunting the survival improvement associated with early
284 and melanoma, documenting its involvement in blunting the susceptibility of tumor cells to lysis by a
285 ents recruitment of Bim or Bax to lysosomes, blunting the TRAIL-induced lysosome membrane permeabiliz
288 below 10%) effectiveness of interventions in blunting the ZIKV transmission from symptomatic cases to
289 e and maternal immunization coverage and 30% blunting, the incidence among neonates (0-2 months) is r
292 hrough increased 4E-BP1 inhibitory activity, blunting this mechanism may represent a novel therapeuti
293 xpression correlated with mortality, whereas blunting TLR gene and protein expression correlated with
294 th following glutamate exposure probably via blunting toxicity from delayed calcium deregulation.
295 flammatory processes to help clear tumors by blunting tumor neovascularization and restoring immunosu
297 function may impair RGS2 activation, thereby blunting vascular relaxation and contributing to hyperte
299 tive, terminal ileum eosinophils and villous blunting were significant predictors of active inflammat
300 ical changes in ill animals included villous blunting with sloughing of epithelial cells, submucosal
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