ライフサイエンスコーパス: bona fide

1 lasticity is revealed by a small fraction of bona-fide 14-mers (<4%) that may enable subunit exchange

2 mmunosorbent assay confirmed the presence of bona fide Abeta oligomers, whereas immunoprecipitation-W

3 that the FDA approved drug hydralazine is a bona fide activator of the NRF2/SKN-1 signaling pathway.

4 reported in Arabidopsis are indicative of a bona fide activity that can be associated with the regul

5 Finally, as predicted for a bona fide AD, mutation of this newly identified AD reduc

6 -in model by inserting an Sgamma2b region, a bona fide AID target, into the first intron of c-myc.

7 Thus, sphincter muscle cells are bona fide, albeit unconventional, photoreceptors.

8 Thus, CRAF is a bona fide alternative oncogene for BRAF/NRAS/GNAQ/GNA11

9 Thus, Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kin

10 ortem damage patterns of a test dataset with bona fide ancient and modern DNA.

11 Our study establishes HMGB1 as a bona fide and targetable DAMP that selectively triggers

12 directly demonstrate that SIVrcm Nef is the bona fide antagonist of red-capped mangabey tetherin.

13 CD14(++)CD16- monocyte differentiation into bona fide anti-inflammatory Mvarphis in a self-autonomou

14 ress, revealing--to our knowledge--the first bona fide apoptotic defect linked to Bok deletion.

15 lepsy with sclerosis is completely devoid of bona fide astrocytes and gap junction coupling, whereas

16 exameric complex, it might not function as a bona fide ATP synthase.

17 kines and IL-23-responsive cells in both the bona fide autoimmune rheumatic diseases rheumatoid arthr

18 fungus Chaetomium thermophilum captured in a bona fide autoinhibited state, which represents a novel

19 We here report that leucettine L41 triggers bona fide autophagy in osteosarcoma U-2 OS cells and imm

20 UIS3 acts as a bona fide autophagy inhibitor by competing with host LC3

21 ages of Bathyarchaeota is similar to that of bona fide bacterial homoacetogens, by having pathways fo

22 PSC) lack many functional characteristics of bona fide beta cells.

23 d NFIB associate with STAT5 at sites lacking bona fide binding motifs.

24 ndent 3'-5' polymerase activity of TLPs as a bona fide biological activity for the first time since i

25 esults support the hypothesis that CelR is a bona fide c-di-GMP synthase and that the nucleotide sign

26 man malignancies, but whether they represent bona fide cancer drivers and therapeutically actionable

27 that eIF4E1b/eIF4E1c-type proteins, although bona fide cap-binding proteins, have divergent propertie

28 control tumors but a network of arterioles, bona fide capillaries, and venules in FGF9-expressing tu

29 Here, we identify a bona fide cardiac-specific Prkaa2 enhancer that is syner

30 We conclude that large COPII vesicles are bona fide carriers of PC1.

31 This allowed for dissecting bona fide caveolar functions from those supported by mer

32 clade, presents the structural features of a bona fide CCD, and is able to cleave zeaxanthin, the pre

33 In this article, we identified bona fide cDCs in chicken spleen.

34 confirm previously identified MARCKS as a a bona fide Cdk5 substrate.

35 wledge, this is the first demonstration of a bona fide cell adhesion molecule, NECL4, regulating chol

36 the membrane-associated peroxidase GPx8 as a bona fide cellular substrate of the HCV NS3-4A protease.

37 lective Sirt2 inhibitors with thalidomide, a bona fide cereblon ligand.

38 Our study correlates bona fide changes in PSP and CBD brains with cellular mo

39 substrates in the ER, and as expected for a bona fide chaperone, it does not interact with folded se

40 Among them, some members exhibited bona fide CHI activity, which catalyze stereospecific cy

41 However, so far the bona fide CHIs are found only in vascular plants, and th

42 Expressing those primitive bona fide CHIs in the Arabidopsis chi mutant restores th

43 inases PKA, AMPK, and LKB1 were validated as bona fide ciliary proteins and PKA was found to regulate

44 endothelial circRNAs fulfill all criteria of bona fide circRNAs.

45 that the PDZ domain of nNOS can behave as a bona fide class III PDZ domain and bind to C-terminal se

46 Sulfolobus solfataricus TFS1 functions as a bona fide cleavage factor, while the paralogous TFS4 evo

47 e p53 transactivation domain have emerged as bona fide clinical candidates for reactivating the tumor

48 Our results identify INO80 as a bona fide component of the proteolytic pathway for RNAPI

49 hat activity-dependent processes are central bona fide components of neuronal TF-differentiation prog

50 re tightly than domains in proteins that are bona fide components.

51 consistent time-independent detection of its bona fide components.

52 ly identified, but nonetheless can represent bona fide compounds, also considerably complicates biolo

53 rvariable region mutants that have different bona fide conformations on the membrane.

54 y Bardet-Biedl syndrome proteins (BBSome) as bona fide constituents of IFT in olfactory sensory neuro

55 nalysis is a valuable method for identifying bona fide contributors to follicular lymphoma transforma

56 ing some CD11c(hi) cells that may not have a bona fide counterpart in vivo.

57 Mesp1-EYFP+ cells are bona fide CPCs and they integrated well in infarcted hea

58 sults clearly demonstrate that Amb a 11 is a bona fide cysteine protease exhibiting a strong allergen

59 s from a C18 aldehyde substrate and thus has bona fide decarbonylase activity similar to that of dmCY

60 5 promoted the protein stability of USP28, a bona fide deubiquitinase of LSD1.

61 d10 rescue studies revealed that Card10 is a bona fide direct miR-181b target.

62 d further demonstrate that Msx2 and Pbx1 are bona fide direct regulators of early Six3.2 distribution

63 y a universally conserved GTPase (HflX) as a bona fide dissociation factor of the S. aureus 100S ribo

64 conserved plasmid-encoded DsbP protein is a bona fide disulfide isomerase and suggest that a dedicat

65 , the structure provides a prime exemplar of bona fide domain-swapping.

66 Here we report that crenactin forms bona fide double helical filaments that show exceptional

67 Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt si

68 chemokines, and p53 gene family members) as bona fide downstream transcriptional targets of TAZ.

69 red by the lack of a gold standard, that is, bona fide driver gene mutations.

70 trafficking proteins have been identified as bona fide drivers of tumorigenesis.

71 ive pharmaceutical ingredient (API)-into the bona fide drug supply poses a significant threat to cons

72 Our work thus identifies TRPA1 as a bona fide drug target for the amelioration of alpha-DC s

73 ial strategy towards eventual acquisition of bona fide drug-resistance mechanisms.

74 ) transcription factors, FOXK1 and FOXK2, as bona fide DVL-interacting proteins.

75 This vector functions as a bona fide E1A-deleted RD vector in infected tumor cells.

76 We demonstrate TaU4 to be a bona fide E2 enzyme through an E2 charging assay.

77 ligand binding domains of PPARgamma and is a bona fide E3 ligase for PPARgamma.

78 invasive high grade mammary carcinomas with bona fide EMT, histologically similar to human metaplast

79 However, validating such candidates as bona fide enhancers requires functional characterization

80 Hence, Mfn2 stands as a bona fide ER-mitochondria tether whose ablation decrease

81 These results indicate that TTP acts as a bona fide ERalpha corepressor and suggest that this prot

82 nly identifies these late-activated genes as bona fide ERalpha targets but describes a novel mechanis

83 The bona fide F-box AnkB effector protein of L. pneumophila

84 acuolar pathogen Legionella pneumophila is a bona fide F-box protein, which is localized to the cytos

85 Cumulatively, we identified UBE2T as a bona fide FA gene (FANCT) that also may be a rare cancer

86 for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

87 ds to the rigid ligand-binding site of these bona fide folate receptors.

88 However, it is crucial to demonstrate the bona fide formation of G4 structures within an endogenou

89 sed assays, we showed that the mutation is a bona fide gain-of-function oncogenic mutation.

90 ether are able to promote the development of bona fide gammadeltaT17 cells from peripheral CD122(-)IL

91 unctions being prerequisites to constitute a bona fide GDI displacement factor.

92 rovide definitive evidence that TRAPPII is a bona fide GEF for the yeast Rab11 homologues Ypt31/32.

93 Overall, similar effects were described for bona fide genes, including RGS2, CD200, and CRISPLD2.

94 e the crystal structure of ctPRC2 bound to a bona fide H3K27M sequence.

95 SDC-1 and SDC-2, but not SDC-3 or SDC-4, are bona fide HCV attachment receptors.

96 eficient T cells were indistinguishable from bona fide highly proinflammatory Th17 cells because they

97 ssociated ultrastructural features represent bona fide HIV protein complexes.

98 -B*57:01, we used this knowledge to identify bona fide HIV-derived peptide epitopes with similar prop

99 dified AddAB even in the complete absence of bona fide hotspot sequences.

100 ular pluripotency via multiple mechanisms in bona fide hPSCs and reprogrammed cells.

101 cells in vitro that exhibit key features of bona fide human beta cells, remain functional after shor

102 f human pluripotent stem cells recapitulates bona fide human developmental haematopoiesis, and outlin

103 are not well characterized, specifically in bona fide human disease tissue.

104 This work demonstrates that BCAN-NTRK1 is a bona fide human glioma driver and describes a general st

105 The data indicate that tumors, including bona fide human NSCLC, can use lactate as a fuel in vivo

106 " is often cited as the primary example of a bona fide hydride that can be isolated and characterized

107 We establish ZFP91 as a bona fide IMiD-dependent CRL4(CRBN) substrate and furthe

108 Therefore, novel strategies to generate bona fide in vitro-induced Treg (iTreg) are critical.

109 The bona fide, in vivo VFT ligands that remain to be identif

110 is activated later during the transition to bona fide induced pluripotent stem cells (iPSCs).

111 anges from homeostasis to stress response to bona fide inflammatory response.

112 y represents the first characterization of a bona fide ino80 mutation in any metazoan, raising the po

113 We also demonstrate a bona fide interaction between six human TCRs and CD1c-my

114 n assays to determine which of these exhibit bona fide interactions.

115 than 170 independent experiments, to filter bona fide interactors.

116 Bona fide intracellular bacterial pathogens, such as Sal

117 at the transcription factor, PPARgamma, is a bona fide intracellular target for S1P and thus suggest

118 attern recognition to accurately distinguish bona fide iPSCs from improperly reprogrammed cells.

119 is, and epithelial junctional remodeling, as bona fide IRF6 partner proteins.

120 this article, we demonstrate that BAFF is a bona fide ISG and that IFN regulatory factors (IRFs) con

121 These data confirm that Neto2 is a bona fide KAR auxiliary subunit that is an important con

122 We establish mammalian NDR1/2 as bona fide kinases that target YAP1 on S127 in vitro and

123 we demonstrated that those cells behaved as bona fide LCs when inserted in a three-dimensional rebui

124 at muscarinic receptor blockade results in a bona fide learning impairment that may arise because cor

125 establish that another MHC-Ib, H2-Q10, is a bona fide ligand for the inhibitory Ly49C receptor.

126 hed to the same extent as that of any of the bona fide ligand+target pairs.

127 or the hypothesis that tetrapods inherited a bona fide limb regeneration programme concomitant with t

128 nd calcium imaging to determine how a set of bona fide lineage-related interneurons contribute to sen

129 age display to isolate peptides that possess bona fide LIR (LC3-interacting region) properties and ar

130 es in vivo upon transplantation-hallmarks of bona fide LMC MNs.

131 In summary, ALT joins PAN/nut1/T1.1 as a bona fide lncRNA of KSHV with potentially important role

132 Our findings uncover a key class of bona-fide LRRK2 substrates and a novel regulatory mechan

133 ly T-lineage progenitors expressed CX3CR1, a bona fide marker for DC progenitors.

134 ing G protein-coupled receptor 5 (LGR5) is a bona fide marker of adult stem cells in several epitheli

135 n at physiological temperature in individual bona-fide mature central synapses.

136 lts establish protein domain distortion as a bona fide mechanism for mechanotransduction in vivo.

137 e, our studies present deep insight into the bona fide mechanisms underlying castration resistance an

138 LM interactions authenticate CAPERalpha as a bona fide member of the UHM family of proteins.

139 gent of African trypanosomiasis, possesses a bona fide member of this family (called TbSNM1) with exp

140 FolR1 expression superimposes with Lmx1a, a bona-fide mesDA lineage marker, during the active phase

141 EF) for the trimeric G protein Galphai and a bona fide metastasis-related gene that serves as a platf

142 unifying mechanism that allows GIV/Girdin, a bona fide metastasis-related protein and a guanine-nucle

143 in is a multimodular signal transducer and a bona fide metastasis-related protein.

144 In vitro MGE-like cells resembled bona fide MGE cells but expressed lower levels of Foxg1

145 visible via optical microscopy, making them bona fide microbes.

146 ntrast to other cell types of the human CNS, bona fide microglia have not yet been derived from cultu

147 l RNAs (sRNAs) but the biological role(s) of bona fide microRNAs (miRNAs) remains unclear.

148 xpansion defect, suggesting that BAFF-R is a bona fide miR-142 target through which it controls B-cel

149 of ATP hydrolysis relative to complexes with bona fide MMR substrates and that MutSbeta increases the

150 mmune-compromised mice, and validate it as a bona fide model of hFL-HCCs by multiple methods.

151 show that Drosophila nonmuscle myosin-2 is a bona fide molecular motor and establish an important lin

152 While some progenitors are bona fide multipotent and contribute progeny to all majo

153 lation is well established, the existence of bona fide N(omega)-methylarginine demethylases (RDMs) is

154 e cyclase AbyU, an enzyme shown here to be a bona fide natural Diels-Alderase.

155 nd that colorectal juvenile polyps in CS are bona fide neoplastic precursor lesions.

156 hromatin and mimicking that functioning on a bona fide NER substrate.

157 This code enabled in silico discovery of bona fide notochord enhancers, including those containin

158 uals also provides evidence for thousands of bona fide novel elements of RNA processing-alternative s

159 ulate FXR activity in vivo, thus providing a bona fide novel therapeutic agent to treat enterohepatic

160 es presented here demonstrate that CPS1 is a bona fide nuclear protein involved in homocitrullination

161 We also identified translocations between bona fide nuclease targets on homologous chromosomes, an

162 cate with each other, but recent findings on bona fide nucleation factors also regulating microtubule

163 ) and 3- and 4-finger ZFNs, and validated 13 bona fide off-target sites for these nucleases by DNA se

164 ining set, which increased the percentage of bona fide off-target sites found within the top PROGNOS

165 tion, and timely differentiation into mature bona fide oligodendrocytes.

166 bundle in the helicase domain of Rep68 as a bona fide oligomerization domain (OD).

167 ovel isoform PRKCE (PKCvarepsilon) acts as a bona fide oncogene in in vitro and in vivo models of tum

168 key role in cell transformation, making it a bona fide oncometabolite.

169 (FDPs) are a family of enzymes endowed with bona fide oxygen- and/or nitric-oxide reductase activity

170 rmination by Pol II, which we validated as a bona fide P-TEFb substrate in vivo and in vitro.

171 As bona fide p53 transcriptional targets, miR-34 microRNAs

172 tissues, we propose a high confidence set of bona fide palmitoylated proteins in brain and provide a

173 cts pancreatic acinar cell injury induced by bona fide pancreatitis-inducing agents, such as POA.

174 Our approach reliably discerns bona fide PAS from false PAS that arise due to internal

175 dicating that the corresponding genes encode bona fide PAT.

176 ase, affected individuals carried additional bona fide pathogenic alleles in another BBS gene.

177 udy identifies c.620C>T;p.S207L as the first bona fide pathogenic RAD51D missense cancer susceptibili

178 dent conformational changes are sensitive to bona-fide phosphorylation on S13 and S16 within the N17

179 Delamination of neural crest (NC) cells is a bona fide physiological model of epithelial-to-mesenchym

180 naceae, this is the first demonstration of a bona fide physiological role for a Tad pilus in this bac

181 We demonstrated that, despite exhibiting bona fide podosomes, these cells presented dysfunctional

182 Thus, Rpb4 is a bona fide Pol II core subunit that functions mainly in m

183 e could not corroborate their findings using bona fide Pol III from two laboratory sources.

184 Identifying a bona fide population of cardiac stem cells (CSCs) is a c

185 trials for managing Wnt-driven tumors, is a bona fide PORCN inhibitor whose IC50 for inhibition of W

186 tch forces at a similar level as observed in bona fide postnatal myocardium; (3) a positive force-fre

187 protein (OSP)/claudin-11 (hOSP), one of the bona fide potential primary target antigens in MS.

188 The bona fide PPARgamma activators we identified induced adi

189 nd these transmembrane interactions define a bona fide pre-integrated intermediate along a facilitate

190 ating from fatty acid synthesis pathway is a bona fide precursor of biotin in B. subtilis.

191 In other disorders, the bona fide prion characteristics are still under investig

192 ere, we show that CARD and PYRIN function as bona fide prions in yeast and that their prion forms are

193 enerated in the absence of any cofactors are bona fide prions provides a strong support for the prote

194 oxide (O2()) and hydrogen peroxide (H2O2) as bona fide products in reactions involving 1- or 2-electr

195 sis framework improves the identification of bona fide prognostic biomarkers from DNA methylation stu

196 Here we show that TaPIN1 is a bona fide prolyl isomerase and that it interacts with th

197 eria and chloroplasts, the identification of bona fide protease substrates has been very challenging.

198 detection that cannot be distinguished from bona fide protein isoforms.

199 CEACAM glycosylation, identifying CEACAMs as bona fide protein receptors for Hp.

200 all size was below the cutoff for annotating bona fide proteins.

201 nfrared spectra that are more reminiscent of bona fide PrP(Sc).

202 ormations in the free form and when bound to bona fide Py-tract RNA ligands.

203 but only RGTA1.RGTB1 and RGTA1.RGTB2 exhibit bona fide Rab-GGT activity, and they are biochemically r

204 encoded by SLC10A1), the recently identified bona fide receptor for HBV and HDV.

205 entified through a biochemical approach is a bona fide receptor for HBV and HDV.

206 as a new regulator of body weight and as the bona fide receptor mediating the metabolic effects of GD

207 g "on-target" DNA breaks at matched pairs of bona fide recombination signal sequences (RSSs).

208 e-resolved redox events, and (ii) screen for bona fide redox-sensor targets.

209 precursor for intracellular signaling and a bona fide regulator of actin cytoskeleton reorganization

210 ata presented here demonstrate that tRFs are bona-fide regulatory microRNA-like small RNAs involved i

211 of Streptomyces coelicolor IHF duplex DNA, a bona fide relative of mIHF, revealed the presence of Arg

212 -) sortable cells that is highly enriched in bona fide reprogramming progenitors.

213 Vgamma6T cells are bona fide resident, but precursors of dermal Vgamma4T ce

214 Despite APOBEC3H being a bona fide restriction factor, there has been no comparat

215 capacity, can functionally substitute to the bona fide Rho GAP, GRAF1 (GTPase Regulator Associated wi

216 and CYLD) demonstrated that USP21 acts as a bona fide RIG-I deubiquitinase to down-regulate antivira

217 with 7-mer and 16-mer synthetic bRNAs reveal bona fide RNA branchpoints in the Dbr1 active site.

218 The presence of bona fide RNA G4s in cells has long been a matter of deb

219 We demonstrate that YonO is a bona fide RNAP of the SPbeta bacteriophage that specific

220 hus, of a different evolutionary origin than bona fide RRs.

221 7L3), SRSF11 and Acinus S', but not with the bona fide RS-domain of SRSF1.

222 ation in a reporter system as efficiently as bona fide RSSs that flank gene segments of the T-cell re

223 by benzimidazoles-related 1 (BUBR1) siRNA, a bona fide SAC component, EDD siRNA abrogated G2/M accumu

224 a criterion to identify and characterize the bona fide SARS-CoV FP.

225 y active, thus demonstrating that LRRK2 is a bona fide self-contained GTPase.

226 We recently identified PfSR1 as a bona fide Ser/Arg-rich (SR) protein that shuttles betwee

227 lla-like protein phosphatase 2 (AtSLP2) is a bona fide Ser/Thr protein phosphatase that is targeted t

228 s of target proteins, with orally available, bona fide small molecules remains a significant but imme

229 We identify Dub3 as a bona fide Snail1 deubiquitinase, which interacts with an

230 This work establishes SORB-1 as a bona fide sorbin family protein-one of the late addition

231 pressive function of PTBP1 and its role as a bona fide splicing activator.

232 ostate physiology, identify c-MYC as a novel bona fide SPOP substrate, and help explain the frequent

233 We verified that this approach captures bona fide sRNA-mRNA interactions.

234 cells fulfill all the criteria required for bona fide SSCs.

235 Here we show that CD25, a bona fide STAT5 regulated gene, is a mechanistically rel

236 at persist for months and continue to act as bona fide stem cells by participating in tissue maintena

237 e transient progenitor cells from permanent, bona fide stem cells in the retina.

238 ELK-interacting protein during mitosis and a bona fide substrate of MELK.

239 Here, we showed that Pah1p is a bona fide substrate of protein kinase C; the phosphoryla

240 tion, suggesting that this mutated form is a bona fide substrate of this degradation pathway.

241 lit ends protein family, Spenito, as a novel bona fide subunit of the methyltransferase complex.

242 The presence of bona fide SUMOylated proteins in the mut5 mutant at 25 d

243 ith only syncytin-Opo1 being the present-day bona fide syncytin active in the opossum and related spe

244 has all of the characteristic features of a bona fide syncytin gene: It is fusogenic in an ex vivo c

245 quivocally shown that psoriasis represents a bona fide T cell-mediated disease primarily driven by pa

246 In addition to being bona fide T. pallidum rare outer membrane proteins, TprC

247 sease patients, and we provide evidence that bona-fide T3 phosphorylation alters Huntingtin exon 1 pr

248 To identify the bona fide target genes of Hog1, we inducibly expressed t

249 uced induction of Bcl-xL and IkappaBalpha, 2 bona fide target genes of the canonical NF-kappaB pathwa

250 on chromosome 10 (PTEN), was identified as a bona fide target of both miR-92a and miR-19a in cholangi

251 his research reveals that mitochondria are a bona fide target of Coxiella effectors and MceA is a com

252 These findings establish DNMT1 as a bona fide target of miR-185 in HCC cells.

253 We demonstrate here that Rab10 is a bona fide target of the GTPase-activating protein AS160,

254 Here we sought to identify a bona fide target of ZIP and, in so doing, unveiled a nov

255 al muscle, in addition to NPR3 and SERPINA3, bona fide targets of MR in other tissues.

256 cells by a process analogous to that used by bona fide TBDT ligands.

257 ms of cytokine production than either Th1 or bona fide Th17 cells, and produced increased amounts of

258 The tetramers defined bona fide Th2 cells.

259 hallenges to translate AXL inhibitors into a bona fide therapeutic option.

260 e results support the notion that SPHK1 is a bona fide therapeutic target for the treatment of AML.

261 llele fraction is a useful predictor to find bona-fide therapeutic-targetable fusion transcripts.

262 the lung rather than residing in the lung as bona fide tissue-resident CD69(+) NK cells.

263 formaldehyde), confirming that it encodes a bona fide TMAO demethylase (Tdm).

264 Our results establish UvrD as a bona fide transcription elongation factor that contribut

265 We recently reported that ZBTB7A is a bona fide transcription repressor of key glycolytic gene

266 Our results prove that HDAC7 is a bona fide transcriptional repressor essential for B cell

267 Mechanistically, we identified FOXO1 as a bona fide transcriptional repressor of HAS2.

268 with affected H3K27 acetylation contained a bona fide TRbeta1-binding site.

269 cus that is selectively demethylated only in bona fide Tregs (Treg-specific demethylated region, TSDR

270 tly, Th1/Tregs arise in atherosclerosis from bona fide Tregs, rather than from T-effector cells.

271 document, for the first time, that, in AILD, bona-fide Tregs produce less interleukin (IL)-10 and are

272 stability of these tRNA-like small RNAs and bona fide tRNAs is monitored by the CCA-adding enzyme.

273 Bona fide trophoblast stem cell lines and extra-embryoni

274 Also, the ability of hESCs to form bona fide trophoblasts has been intensely debated.

275 units of the complex have been shown to have bona fide tumor suppressor activity.

276 Here we show that KMT2D functions as a bona fide tumor suppressor and that its genetic ablation

277 nd biologic proofs that TUSC4 functions as a bona fide tumor suppressor by regulating the protein sta

278 ings provide genetic evidence that Bap1 is a bona fide tumor suppressor gene and offer key insights i

279 convincing genetic evidence that MCPH1 is a bona fide tumor suppressor gene.

280 the H3K27me3 demethylase UTX functions as a bona fide tumor suppressor in T-ALL.

281 TET2 functions as a bona fide tumor suppressor particularly in the pathogene

282 ross a variety of human cancers and also has bona fide tumor suppressor properties.

283 Although RASSF1A is now considered a bona fide tumor suppressor protein, the role of MOAP-1 a

284 Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in r

285 Long understood as a bona fide tumor suppressor that safeguards the integrity

286 In parallel, we validate CUX1 as a bona fide tumor suppressor using mouse transposon-mediat

287 whereas liver-specific microRNA (miR)-122, a bona fide tumor suppressor, is down-regulated in hepatoc

288 In total, we reveal that PTPRD is a bona fide tumor suppressor, pinpoint PTPRD loss as a cau

289 tissue types, supporting its role as a broad bona fide tumor suppressor.

290 mary, we provide evidence that both HATs are bona fide tumor suppressors that control MHCII expressio

291 nzymatic CHIs, suggest that emergence of the bona fide type II CHIs is an ancient evolution event tha

292 archaeum subterraneum' operate together as a bona fide ubiquitin modification system, mediating a seq

293 te cancer antigen 3 has emerged as the first bona-fide urinary biomarker for prostate cancer.

294 urthermore, GSC also transdifferentiate into bona fide vascular endothelial cells (GEC), which inheri

295 t of our knowledge, the first characterized, bona fide virulence factor secreted by Acinetobacter spe

296 nd from primordial selfish genetic elements, bona fide viruses evolved on multiple, independent occas

297 These findings identifying STRA6 as a bona fide vitamin A transporter have important implicati

298 , it is feasible to generate high numbers of bona fide XCR1(+) human DC in vitro as a model to deciph

299 report that BCL-2 ovarian killer (BOK) is a bona fide yet unconventional effector of MOMP that can t

300 ic TetR from S. agalactiae (PDB 3KKC) is the bona fide zinc efflux regulator SczA, and binds two zinc