ライフサイエンスコーパス: bond formation

1 is acidic borane with concomitant C-H or C-C bond formation.

2 inant pathway, enabling dual carbon-nitrogen bond formation.

3 uring wetting-drying cycles, promote peptide bond formation.

4 a a sequential carbon-carbon/carbon-selenium bond formation.

5 a chiral environment conducive of asymmetric bond formation.

6 profiles consistent with incorrect disulfide bond formation.

7 ted benzo[b][1,6]naphthyridines via multiple bond formation.

8 ision in E. coli is dependent upon disulfide bond formation.

9 re energetically accessible pathways for O-O bond formation.

10 9-BBN and Ph3 B, provide facile B-B' single bond formation.

11 eactions, which proceed with concomitant C-H bond formation.

12 y powerful tools for achieving carbon-carbon bond formation.

13 ids and coupling agents widely used in amide bond formation.

14 creased wet adhesion through increased ionic bond formation.

15 and instead proceeds through nickel-mediated bond formation.

16 of the subsequent functionalization via C-C bond formation.

17 n of a doubly oxidized Co(IV)2 center on O-O bond formation.

18 leophiles, which attack the metal before C-C bond formation.

19 r efficient B-N, B-O, and unprecedented B-CN bond formation.

20 rsatile tool for the ring closure by peptide bond formation.

21 athway for integrating light absorption with bond formation.

22 in environments that favor intramolecular H-bond formation.

23 hrough inter- and intramolecular C-C and C-N bond formation.

24 a gold-activated alkyne with subsequent C-B bond formation.

25 te bound acyl-CoA and initiate carbon-carbon bond formation.

26 copper, enables chemoselective carbon-carbon bond formation.

27 alkenes prior to the terminating C(sp(3))-Si bond formation.

28 ne while simultaneously accelerating the C-C bond formation.

29 Ub/Ubl activation: adenylation and thioester bond formation.

30 -carbon occurs concomitantly with C-Pd sigma-bond formation.

31 ribosome prior to the first cycle of peptide bond formation.

32 preceding the Csp(2)-Csp(2) or Csp(3)-Csp(2) bond formation.

33 effects influence the identity and timing of bond formation.

34 g the alpha-ketoamide residue through C(1)-N bond formation.

35 lve the mechanistic basis for cadherin ideal bond formation.

36 ctional group is required at the site of C-C bond formation.

37 nic coordination bonding during covalent C-C bond formation.

38 and further protonation to initiate hydrogen bond formation.

39 a condensation domain that catalyzes peptide bond formation.

40 ol-3-phospho-(1'rac-glycerol)) via disulfide bond formation.

41 mpounds is a widely practiced method for C-C bond formation.

42 alpha atom thioether bonds, or carbon-carbon bond formation.

43 protein order as manifested through hydrogen bond formation.

44 conducted to study the mechanism of this C-C bond formation.

45 mediate was attributed to intramolecular I-I bond formation.

46 etallic compounds that promote catalytic C-C bond formation.

47 developed via C-H functionalization and C-N bond formation.

48 ins the propensity of gold to facilitate C-C bond formation.

49 cle where it serves as the reductant for C-C bond formation.

50 ylation; 1,2- 1,3-, or 1,4-addition; and C-O bond formation.

51 ctivation by R655C did not require disulfide bond formation.

52 ons such as alkenylation, arylation, and C-N bond formation.

53 g groups on the donor favor alpha-glycosidic bond formation.

54 /or Ni(IV) intermediates and followed by C-C bond formation.

55 ptide derivatives in yields up to 80% by P-C bond formation.

56 ly pathways can enable control over covalent bond formation.

57 ossible mechanism for the photosynthetic O-O bond formation.

58 new approaches to transition-metal-free C-C bond formations.

59 via one carbon-oxygen and one carbon-carbon bond formations.

60 arboamination sequence involving C-C and C-N bond formations.

61 /Cr-mediated coupling was used for three C-C bond formations.

62 d represents a new approach for multiple C-N bond formations.

63 nd to be a competent electrocatalyst for O-O bond formation, a key transformation pertinent to the OE

64 Spontaneous isopeptide bond formation, a stabilizing posttranslational modifica

65 sure steps which, through intramolecular C-O bond formation, allow stepwise planarization of oligonap

66 We report here on the use of covalent bond formation among monomers, compensating for intermol

67 The synergy between bond formation and bond breaking that is typical for per

68 ergy reactive intermediates by synchronizing bond formation and bond cleavage.

69 azolidine-3,5-diones and benzoxazoles by N-N bond formation and C,O linkage, respectively, represents

70 t with a unique altered transition state for bond formation and cleavage for UTP/dT incorporation com

71 Rapid disulfide bond formation and cleavage is an essential mechanism of

72 ated 8-N-benzyladenosine ligand for covalent bond formation and confirmed targeted irreversible inhib

73 s the predominant pathway enabling dual C-Cl bond formation and contradict an alternative pathway inv

74 that CnsC catalyzes the C3-C3' carbon-carbon bond formation and controls the regioselectivities of th

75 athway for oxyboration that avoids B-O sigma bond formation and enables this catalyst-free route.

76 aldol are important since they allow for C-C bond formation and give higher molecular weight oxygenat

77 nition, stable protein expression, disulfide bond formation and glycosylation that are critical for s

78 dherin mutants that promote or inhibit ideal bond formation and measure their force-dependent kinetic

79 the study of the interplay between covalent bond formation and noncovalent interactions has become i

80 S3 is the last semi-stable state before O-O bond formation and O2 evolution.

81 he ER requires core glycosylation, disulfide-bond formation and proline isomerization.

82 mic reticulum (ER), Ero1 catalyzes disulfide bond formation and promotes glutathione (GSH) oxidation

83 em iron enzyme capable of catalysing the C-S bond formation and sulfoxidation, herein, we discovered

84 osulfur ligands, we describe the gold-sulfur bond formation and the nature of the resulting interface

85 sed stereoselectivity models, namely the C-C bond formation and the protonation steps.

86 This technology relies on lower-barrier bond formation and/or dissociation routes made available

87 gents, the reaction proceeds through two C-N bond formations and an oxidative dehydrogenation to form

88 uch as enzyme acylation, transacylation, C-C bond formation, and chain transfer, to the overall selec

89 rength that promotes intramolecular hydrogen bond formation, and deformation of the reverse micelle s

90 nt chemical bond, non-covalent interactions, bond formation, and exotic 3-center-2-electron species.

91 induced protein dysfunction due to disulfide bond formation, and H2 can protect oxidation of this pro

92 rs of messenger RNA (mRNA) decoding, peptide-bond formation, and ribosome dynamics during translation

93 It first catalyzes amide bond formation, and then the intramolecular cyclodehydra

94 s a sequential carbon-nitrogen/carbon-oxygen bond formations, and the combination of AuCl3 with AgSbF

95 erefore, the enzymes that catalyze disulfide bond formation are involved in multiple biological proce

96 Enzymes that catalyze carbon-silicon bond formation are unknown in nature, despite the natura

97 Initial studies show that C-C, C-N and C-S bond formations are also amenable.

98 -selective olefin functionalizations and C-C bond formations are also included.

99 amolecular cyclizations of esters enable C-C bond formation as catalytic B(C6 F5 )3 can be used to ef

100 opyridine/amidine and isothiocyanate via N-S bond formation at ambient temperature.

101 It is unclear why certain catalysts favour bond formation at C6, and-although there are a small num

102 Strategies that allow C-C bond formation at inert carbon-hydrogen (C-H) bonds enab

103 weak base, lysine amino groups underwent C-N bond formation at room temperature.

104 g translation correlates with slowed peptide bond formation at successive proline sequence positions

105 A new method which enables carbon-carbon bond formation at the alpha'-position of silylenol ether

106 aromatic rings in order to promote hydrogen bond formation at the correct distance and antiparallel

107 thfully decoding mRNA and catalyzing peptide bond formation at the peptidyl transferase center (PTC).

108 logy allows for amide-directed selective C-C bond formation at unactivated sp(3) C-H bonds in molecul

109 hetic pathway via catalysis of carbon-carbon bond formation between a glutamate and tyrosine side cha

110 Imine-bond formation between chiral amines and commercially av

111 a 90 degree rotation of His249 and disulfide bond formation between Cys280 and Cys283.

112 und to the active site of GSTP1; no covalent bond formation between hPL and GSTP1 was observed.

113 Our findings document covalent bond formation between the asparagusic acid moiety and t

114 atom abstraction from C4 is facilitated by H-bond formation between the attacking peroxyl radical and

115 ogether provided strong evidence of covalent bond formation between the photoacids and the polymer me

116 beling approach which is based on isopeptide bond formation between two recognition peptides, SpyTag

117 synchronous transition state allowing easier bond formation between two sterically hindered carbons.

118 Ga(I)-catalyzed C-C bond formations between allyl or allenyl boronic esters

119 er is not directly involved in the catalytic bond formation but rather serves, cooperatively with the

120 lyst to promote stereocontrolled C-N and C-S bond formation by activation of an achiral sulfenylating

121 y slow partly because of reversible covalent bond formation by some gliptins, and partly because of s

122 C-C bond formation by the cis-isomer is suppressed by hydrog

123 The significance of this carbon-carbon bond formation can be gauged by the manifold constraints

124 Accurate and efficient disulfide bond formation can be vital for protein function; theref

125 tinct biological settings in which disulfide bond formation can take place belie the simplicity of th

126 dvanced understanding of the fundamental N-N bond formation/cleavage processes occurring at the trans

127 the intermediate enolate from a C-C to a C-O bond formation, contrary to the already known alkylation

128 and complementary method for carbon-nitrogen bond formation could be developed through the destabiliz

129 ses, which involve a combination of covalent bond formation, degenerate bond exchange, and noncovalen

130 Dimerization of BslA, mediated by disulfide bond formation, depends on two conserved cysteine residu

131 after intercalation, the inserted ion-oxygen bond formation destabilizes the transition-metal framewo

132 igand (1,10-phenanthroline) facilitates C-Se bond formation during heating via a mechanism that likel

133 ons (e.g. strept(avidin)/biotin) or covalent bond formations (e.g. inverse electron demand Diels-Alde

134 factor needed for efficient proline-proline bond formation, EF-P, suppress Deltarep DeltauvrD lethal

135 ses is a perfluoroalkyl lithium-mediated C-C bond formation, either intramolecular or intermolecular,

136 between peptides were reinforced by covalent bond formation, enabling the fiber elongation.

137 Therefore, inhibitors of disulfide bond formation enzymes could have profound effects on pa

138 lectivity can be primarily controlled by C-C bond formation even though the reaction rate is dictated

139 on stepwise, sequentially directed disulfide bond formation, exemplified by the synthesis of four-dis

140 ructural basis for adenylation and thioester bond formation exhibited by SUMO E1 is indeed conserved

141 The reaction likely involves sequential C-N bond formation followed by C(CO)-C(alkyl) bond cleavage.

142 s of sequential Pd-catalyzed carbon-nitrogen bond formation followed by Lewis acid catalyzed intramol

143 The bonding formation for ultrasonic welding of dissimilar m

144 Interestingly, the rate of C-C bond formation from a Ni(III) center is enhanced in the

145 ted nickel(III) complexes is faster than C-F bond formation from any other characterized aryl metal f

146 vide the first demonstrations of C-N and N-N bond formation from attack of C-based and N-based nucleo

147 ion scope, generating biocatalysts for amide bond formation from carboxylic acid and amine.

148 In particular, methods for carbon-carbon bond formation generally rely on two-electron mechanisms

149 ctical and efficient methods for C-C and C-X bond formation has attracted a great deal of current att

150 Although C-C bond formation has been a staple of organic synthesis, t

151 Hydrogen bond formation has been identified between the NH amide

152 e past decade, metal-free approaches for C-C bond formation have attracted a great deal of attention

153 genation, C-H bond activation, C-C, C-N, C-O bond formation, hydrolysis of silanes, oligomerization,

154 sources: stereoelectronic assistance of C-C bond formation (i.e., "LUMO umpolung") and crossover fro

155 ir CCA-ends into the PTC thus making peptide bond formation impossible.

156 Finally, we discuss disulfide bond formation in a cellular context and identify import

157 agents via two C-N and one C-X (X = C, N, O) bond formation in a single step under uniform reaction c

158 th a second copper complex that mediates C-N bond formation in an out-of-cage process.

159 captoethanol, resulting in reduced disulfide bond formation in inositol 1, 4, 5-trisphosphate recepto

160 In conclusion, disulfide bond formation in oral bacteria is an emerging field, an

161 of the Wacker process for C horizontal lineO bond formation in terminal olefins can be initiated by a

162 iate 2, bypassing the need for oxidative N-N bond formation in the 1,2,4-triazole synthesis.

163 tes these phosphorylation events and new C-C bond formation in the absence of biotin has remained a m

164 moselective ring-opening/C(sp(3) )-C(sp(3) ) bond formation in the copper(I)-catalyzed reaction of cy

165 re divalent metal cations for phosphodiester bond formation in the polymerase site and for hydrolytic

166 ophobic packing, metal binding, or disulfide bond formation in the protein core.

167 macrocycle of diazonamide A features C16-C18 bond formation in the Suzuki-Miyaura cross-coupling and

168 asymmetry between C-H bond breaking and O-H bond formation in the transition state is minimized, and

169 the mechanisms and consequences of disulfide bond formation in vivo by reviewing chemical principles

170 Co(III)-mediated intramolecular SN2-type C-C bond formation in which the carboxylate moiety acts as a

171 proceeds via C-H bond activation/C-O and C-C bond formations in a single reaction vessel.

172 l-carbon quaternary centers via multiple C-C bond formations in a straightforward manner.

173 nylations of organohalides are important C-C bond formations in chemical synthesis.

174 N bonds cleavage followed by cascade C-N/C-S bonds formation in one-pot.

175 al orientation was achieved through chemical bond formation, in particular, by metal coordination.

176 ycosylation, additional pH-induced disulfide bond formation, increased percentage of nonvolatile mate

177 We show that disulfide bond formation inhibits filament assembly and that the C

178 was studied and led to the following The N-N bond formation involves a diradical as intermediate, whe

179 general regio- and stereoselective gamma-C-C bond formation is achieved using alpha-halocarbonyl comp

180 C-H and sp(2) C-H coupling reaction for C-C bond formation is described to access unsymmetrical diar

181 skipped diynes via an enantiodetermining C-C bond formation is described using StackPhos as ligand.

182 s of dihydrobenzofurans by a direct aryl C-O bond formation is described.

183 Imine bond formation is employed to install a pyridyl to the a

184 Reversibility in bond formation is essential to generate ordered networks

185 In Actinomyces oris, disulfide bond formation is needed for pilus assembly, coaggregati

186 Carbon-carbon (C-C) bond formation is paramount in the synthesis of biologic

187 tionalization for intermolecular C-N and C-O bond formation is reported.

188 C(sp(3))-N bond formation is second-order in amine, consistent with

189 It is found that the first carbon-carbon bond formation is the rate-limiting step, followed by a

190 rse kinetic isotope effect indicate that H-H bond formation is the rate-limiting step.

191 However, the biophysical mechanism for ideal bond formation is unknown.

192 und Ru(V) horizontal lineO intermediate (O-O bond formation) is the rate limiting step for OER cataly

193 he key chemical step of translation, peptide bond formation, is among the slower enzymatic reactions.

194 ocyclic benziodoxole triflate results in N-I bond formation leading to a new type of sulfoximidoyl-co

195 iction peptidase), suggesting that disulfide bond formation may additionally stabilize NCR peptides d

196 A detailed understanding of the O-O bond formation mechanism remains a challenge, and will r

197 is used to discriminate between proposed O-O bond formation mechanisms.

198 icient, environmentally benign catalytic B-C bond formation method is presented that uses organosilic

199 occurring with and without bond breaking or bond formation, namely ring-opening reactions and cis-tr

200 d this copper-induced mechanism of disulfide bond formation obviates the need for a thiol/disulfide o

201 Facile P-P bond formation occurs from this species through intermol

202 nts of 75 and 20 s(-1); rapid phosphodiester bond formation occurs with a Keq of 2.2 and 1.7, and the

203 is the first report on an intramolecular C-N bond formation of an amide-tethered benzylic/allylic sys

204 th X-ray photoelectron spectroscopy, and O-H bond formation of H interstitial defects is predicted an

205 iazoles through intramolecular oxidative S-N bond formation of imidoyl thioureas by phenyliodine(III)

206 ntially accelerate the kinetics of disulfide-bond formation of several conotoxins.

207 It is indeed shown that H-bond formation of the reacting NH3 with the solvent dras

208 ve been immobilized on SH groups of GQDs via bonding formation of Ag-S and anti-HCV have been loaded

209 has been accomplished via alkene vicinal C-N bonds formation of 2-bromo-2-alkenones with guanidine av

210 yzed (anaerobic) oxidative carbon-heteroatom bond formation on sp(3)- and sp(2)-C-H bonds as well as

211 The reaction proceeded via selective C-N bond formation on the more electrophilic alkynyl carbon

212 ed structure to allow cross-domain disulfide bond formation or cross-linking by bismaleimides of vari

213 rted bias toward reaction classes like amide bond formations or Suzuki couplings.

214 major steps: water oxidative activation, O-O bond formation, oxidative activation of peroxide interme

215 In the Escherichia coli disulfide bond formation pathway, the periplasmic protein DsbA int

216 ven sunlight can be used to achieve this C-C bond formation proceeding through a free radical mechani

217 In this process, carbon-nitrogen bond formation proceeds through a key aminium radical ca

218 io calculations suggest that carbon-fluorine bond formation proceeds via a concerted transition state

219 al difference between Ni and Pd in mediating bond-formation processes.

220 ss underwent copper-catalyzed tandem C-N/C-C bond formation, producing isoindolin-1-one derivatives i

221 go base-mediated C-arylation followed by N-N bond formation, producing unstable five-membered ring in

222 catalyzed C-H functionalization/two-fold C-N bond formation protocol for the syntheses of N-aryl benz

223 ophilic cyclization, as opposed to S-B sigma bond formation, providing a mechanistically distinct pat

224 e time gap between C-H bond-breaking and C-O bond formation ranges from 30 to 150 fs, close to the <2

225 prepared involving an anion-templated amide bond formation reaction at the macrocyclization step.

226 The generality of the C-C bond formation reaction between the two sugar units is e

227 (mu2 -C2 O4 -kappaO:kappaO'')], 6, in a C-C bond formation reaction commonly anticipated for oxalate

228 tandem isomerization followed by C-O and C-C bond formation reaction strategy developed by our own gr

229 -C18 double bonds, a Suzuki-Molander C21-C22 bond formation reaction, and a Kita-Trost macrolactoniza

230 role for the interface in an accelerated C-C bond-formation reaction between 6hydroxy-1-indanone and

231 ore, is how do EgtB enzymes catalyze the C-S bond-formation reaction, while also preventing a dioxyge

232 involved in stoichiometric and catalytic C-C bond formation reactions.

233 otope effects pertinent to bond-cleavage and bond-formation reactions during chloramination of the te

234 tal role in stabilizing key intermediates in bond-formation reactions.

235 nd the solid state, and exhibits limited C-C bond formation reactivity.

236 ing, both of these silylcarbynes undergo C-C bond formation, releasing silylated C2O1 fragments and d

237 t several key steps following phosphodiester bond formation remain structurally uncharacterized due t

238 the mechanisms of adenylation and thioester bond formation revealed by SUMO E1 structures are though

239 amic view of corticostriatal activity during bond formation, revealing how social interactions can re

240 rategy is inspired by nature's carbon-carbon bond formation sequence, which facilitates the construct

241 er reaction conditions and mechanisms of O-O bond formation should be obtained.

242 ortion of the review is dedicated to the O-O bond formation step as the key step in water oxidation c

243 ds to MPK in the selectivity-determining C-C bond formation step leading to the R-Z and S-Z product r

244 The nucleophilic C-S bond-formation step happens subsequently concomitant to

245 hanisms are at present suggested for the O-O bond-formation step in photosystem II.

246 pes of reactions, the subsequent C-C and C-X bond formation steps may occur via either oxidative addi

247 Along with amide bond formation, Suzuki cross-coupling, and reductive ami

248 he most frequently used reactions were amide bond formation, Suzuki-Miyaura coupling, and SNAr reacti

249 proved unsuccessful, both amidation and C-N bond formation tactics with the more electron-rich napht

250 n this way we have accessed reversible amide bond formation that allows crystalline order to develop.

251 ally plausible mechanism for peptide (amide) bond formation that is enabled by alpha-hydroxy acids, w

252 s and one of the distances shortens to allow bond formation, the other tends to lengthen.

253 tion cycle involves the critical step of O-O bond formation, the transition metal oxide radical thoug

254 Outside of radical bond formation, there is a dearth of evidence that sugge

255 teps that give rise to selective C-C and C-N bond formations, thereby releasing 2 equiv of hydrogen a

256 eps which give rise to selective C-C and C-N bond formations, thereby releasing hydrogen and water.

257 the IspD binding site, followed by disulfide bond formation through attack of an active site cysteine

258 pectively, and subsequent intramolecular C-N bond formation through palladium-catalyzed aza-Michael r

259 nique approach to transfer-hydrogenative C-C bond formation, thus providing examples of reductive het

260 yzed enantioselective C-H activation and C-C bond formation, thus significantly expanding the scope o

261 tion of unactivated alkenes coupled with C-C bond formation to an aryl ring is reported.

262 >10:1), while softer tertiary radicals favor bond formation to C-4 (4.7->29:1).

263 Covalent bond formation to Cys-154 was confirmed by incubation of

264 5 with the free radical NO(g) results in C-N bond formation to give [Cu](eta(2)-ONC6F5).

265 ster chemistry with dynamic organic covalent bond formation to give a new crystalline, extended frame

266 uses the same activating principle as amide bond formation to replace a carboxylic acid moiety with

267 iggers a series of steps with double C-N/C-N bond formation to the final product.

268 application of this new Au(I)-catalyzed C-N bond formation to the preparation of a variety of N-alke

269 lective amine-based catalyst that allows C-C bond formations to be performed in the presence of as li

270 lectivities of the pair of subsequent aminal bond formations to yield the communesin core.

271 ck on the alkene and subsequent nucleophilic bond formation, to the nucleophile-assisted alkene activ

272 nclusion of LiClO4 is found to favor the C-C bond formation transition state to the S-E isomer in the

273 Direct C(sp(3))-C(sp(2)) bond formation under transition-metal-free conditions of

274 adical that undergoes asymmetric C(sp(3))-CN bond formation upon reaction with a chiral copper cataly

275 The key steps include carbon-carbon bond formation using an alpha-chloro sulfide, regioselec

276 ent system was found to enable effective C-N bond formation using aryl amines while EtOH is not requi

277 ailable for dehalogenation and carbon-carbon bond formation using aryl halides, strategies that provi

278 yclization followed by an intermolecular C-N bond formation using electrophilic azidoiodinane.

279 rylamines are shown to undergo oxidative C-C bond formation using quinone-based chloranil/H(+) reagen

280 idative C(sp(3))-H functionalization/C-O/C-N bonds formations using tetrabutylammonium iodide as the

281 experiment with TEMPO is consistent with C-N bond formation via an alkyl radical in an out-of-cage pr

282 The pendant phosphonate base mediates O-O bond formation via intramolecular atom-proton transfer w

283 the proximal base might be beneficial in O-O bond formation via nucleophilic water attack on an oxo s

284 ies support CO2 activation and carbon-carbon bond formation via single-electron pathways, and we expe

285 , the development of methods for sp(3)-sp(3) bond formation via transition metal catalysis has been h

286 the scarcity of metal-catalyzed C-heteroatom bond formations via C-OMe cleavage is striking, with iso

287 step forward for designing new C-heteroatom bond formations via C-OMe scission.

288 Ester bond formation was confirmed by nuclear magnetic resonan

289 The study on C-S bond formation was investigated by UV-visible spectropho

290 Of relevance, the disulfide bond formation was much slower in Prx2 (k3 = 0.31 s(-1))

291 to protein processing and correct disulfide bond formation, we investigated whether the conserved ex

292 fluoroketones can be readily achieved by C-C bond formation when the appropriate palladium catalyst a

293 chemical step of peptide synthesis is amide bond formation, which is typically catalyzed by the cond

294 ise shear stress transmits tension and catch-bond formation with L-selectin via sLe(x), resulting in

295 is protonation of the flavin N5 and strong H-bond formation with the Gly-141 carbonyl.

296 active site geometry further suppresses C-C bond formation with the l-G3P enantiomer of d-G3P.

297 Subsequent C-C bond formations with imines have proceeded in high yield

298 veal a surprising, biased order of disulfide bond formation, with early formation of the C-terminal d

299 equential nucleophilic and electrophilic C-N bond formations, with the latter effecting the key dearo

300 at copper phenanthroline catalyzed disulfide bond formation within five cysteine pairs and increased