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1 ly, mutations in the gene for the proteinase bone morphogenetic 1 (BMP1) were reported in two recessi
3 l ectoderm (PPE) that requires inhibition of bone morphogenetic protein (BMP) and expresses the key r
6 y 2 signaling pathways: the "iron-regulated" bone morphogenetic protein (BMP) and the inflammatory JA
8 t in the context of reduced ShcA levels, the bone morphogenetic protein (BMP) antagonist chordin-like
9 We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 de
13 expression of chordin (chd), which encodes a bone morphogenetic protein (BMP) antagonist that is loca
14 cted gene aberrant in neuroblastoma (DAN), a bone morphogenetic protein (BMP) antagonist we detected
15 e that CHRDL1 encodes Ventroptin, a secreted bone morphogenetic protein (BMP) antagonist, the molecul
21 iron homeostasis by direct interaction with bone morphogenetic protein (BMP) ligands to induce hepci
22 that injury stimulates the production of two bone morphogenetic protein (BMP) ligands, Dpp and Gbb, w
23 Smad transcription factors critical for the bone morphogenetic protein (BMP) pathway and the DNA rep
25 equencing (ChIP-seq) data, we identified the bone morphogenetic protein (BMP) pathway as a potential
27 ion and specific decreased expression of the bone morphogenetic protein (BMP) pathway component Mad.
30 in particular the dual modulation of Wnt and bone morphogenetic protein (BMP) pathway signaling, this
31 on the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) pathway, which is one o
37 ly in mice, which specify germ cells through bone morphogenetic protein (BMP) signal-mediated inducti
38 red neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then acti
39 ects of Matn3 on chondrocyte hypertrophy and bone morphogenetic protein (Bmp) signaling by quantifyin
41 Loss of the growth-suppressive effects of bone morphogenetic protein (BMP) signaling has been demo
44 hem, a source of Wingless-related (WNT) and bone morphogenetic protein (BMP) signaling in the dorsom
45 result of differential regulation of Wnt and bone morphogenetic protein (BMP) signaling in these two
46 has been constructed and, here, we show that bone morphogenetic protein (BMP) signaling is essential
51 ibit Ras signaling and may also activate the bone morphogenetic protein (BMP) signaling pathway in co
53 coagulation factor fibrinogen activates the bone morphogenetic protein (BMP) signaling pathway in ol
58 rates that RNAi silencing of a member of the Bone Morphogenetic Protein (BMP) signaling pathway, Deca
59 er, SMAD4 is also a central component of the bone morphogenetic protein (BMP) signaling pathway, impl
60 f these mutants target the components of the Bone Morphogenetic Protein (BMP) signaling pathway, reve
62 ls (DCDMLs), we investigated how the FGF and bone morphogenetic protein (BMP) signaling pathways posi
63 axis is established and patterned by Wnt and bone morphogenetic protein (BMP) signaling pathways, res
66 between transforming growth factor beta1 and bone morphogenetic protein (BMP) signaling plays an impo
73 elf-renewing SCs, Foxc1 activates Nfatc1 and bone morphogenetic protein (BMP) signaling, two key mech
74 per, notable for roles in Wingless (Wnt) and bone morphogenetic protein (BMP) signaling, were differe
81 wingless-related integration site (WNT), and bone morphogenetic protein (BMP) signalling interactions
82 reveals that complementary components of the bone morphogenetic protein (BMP) signalling pathway are
83 s myocardial trabeculation through Erbb2 and bone morphogenetic protein (BMP) signalling, we discover
84 pression and signaling are up-regulated, and bone morphogenetic protein (BMP) signals are impaired.
85 rfamily of signaling pathways, including the bone morphogenetic protein (BMP) subfamily of ligands an
86 c mathematical model of tissue genesis using bone morphogenetic protein (BMP) to represent of a class
87 and Wnt/beta-catenin) or share (TGFbeta and bone morphogenetic protein (BMP)) core signaling compone
89 ys, epidermal growth factor receptor (EGFR), bone morphogenetic protein (BMP), Jun kinase (JNK), JAK/
90 dels commonly increase signaling of the Wnt, bone morphogenetic protein (BMP), or Ras/ERK pathways, c
91 FE) is specified by sequential inhibition of bone morphogenetic protein (BMP), transforming growth fa
92 ial cells (recell-dTBs); 3) dTBs seeded with bone morphogenetic protein (BMP)-2 (dTB-BMPs); and 4) fr
94 owth factor (TGF)-beta family, TGF-beta1 and bone morphogenetic protein (BMP)-2, in synovial fibrobla
96 sly, we demonstrated that transplantation of bone morphogenetic protein (BMP)-induced astrocytes deri
100 in chicken embryos to demonstrate a role for bone morphogenetic protein (BMP)/SMA and MAD related (Sm
102 ad2/3 pathway and activation of the parallel bone morphogenetic protein (BMP)/Smad1/5 axis (recently
103 was accompanied by changes in expression of bone morphogenetic protein (BMP)/sons of mothers against
106 es the gene encoding hepcidin (HAMP) via the bone morphogenetic protein (BMP)6 signaling to SMAD.
108 C1s, sea urchin epidermal growth factor, and bone morphogenetic protein (CUB) domains of uncertain fu
109 s of VBA, with and without recombinant human bone morphogenetic protein (rhBMP)-2, under space-making
110 hyperactive transforming growth factors beta/bone morphogenetic protein (TGFbeta/BMP) signaling in dK
111 These nonanticoagulant compounds impair bone morphogenetic protein /sons of mothers against deca
112 bsence of the type I collagen C-propeptidase bone morphogenetic protein 1 (BMP1) causes type XII oste
115 Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are secreted durin
117 terms of osteoblastic differentiation using bone morphogenetic protein 2 (BMP-2) added to the medium
118 d a positive effect of tissue-derived BGN on bone morphogenetic protein 2 (BMP-2) function, which is
122 study, we discovered the double deletion of bone morphogenetic protein 2 (Bmp2) and bone morphogenet
123 ation of an injectable and porous nCS/A with bone morphogenetic protein 2 (BMP2) gene-modified MSCs a
126 n of smooth muscle contractions by secreting bone morphogenetic protein 2 (BMP2), which activates BMP
128 ptide nanostructures amplified signalling of bone morphogenetic protein 2 significantly more than the
129 phogen action during animal development, the bone morphogenetic protein 2/4 (BMP2/4)-like ligand Deca
130 infection and transcript analysis identified bone morphogenetic protein 4 (BMP4) as a candidate endot
132 n of bone morphogenetic protein 2 (Bmp2) and bone morphogenetic protein 4 (Bmp4) in the dental epithe
133 response to transient (24-36 h) exposure to bone morphogenetic protein 4 (BMP4) plus inhibitors of A
134 coprotein 1 (GLG1) expression and downstream bone morphogenetic protein 4 (BMP4) signaling and also r
135 es different concentrations of activin A and bone morphogenetic protein 4 (BMP4) to polarize cells in
139 e been identified, including sonic hedgehog, bone morphogenetic protein 4 and multiple members of the
141 le protocol, using defined medium containing bone morphogenetic protein 4 by which human pluripotent
143 e framework whereby activation of TGF-beta2, bone morphogenetic protein 4, Wnt/beta-catenin, or immun
148 ether these molecules intersect in vivo with bone morphogenetic protein 6 (BMP6)/mothers against deca
150 ansforming growth factor beta (TGFbeta), and bone morphogenetic protein 7 (BMP7), CD1c(+) dendritic c
152 VEGF-A, VEGF-C, VEGF-D, VEGF-A isoform 121, bone morphogenetic protein 7, macrophage colony-stimulat
154 (drMM) in the presence of human recombinant bone morphogenetic protein 7/human recombinant fibroblas
155 cluding fibroblast growth factor 21 (FGF21), bone morphogenetic protein 8b (BMP8b), growth differenti
157 T is caused by loss-of-function mutations in bone morphogenetic protein 9 (BMP9)-ALK1-Smad1/5/8 signa
161 in vitro, and we identified ligands for the bone morphogenetic protein and insulin pathways as proad
162 otein negatively regulates the activities of bone morphogenetic protein and phosphoinositide 3-kinase
163 To address whether elevated activities of bone morphogenetic protein and PI3K/AKT signaling pathwa
164 valves demonstrated activation of canonical bone morphogenetic protein and Wnt/beta-catenin signalin
165 lls (hESCs) have been routinely treated with bone morphogenetic protein and/or inhibitors of activin/
166 cardiogenic fate of CNC(kit) is regulated by bone morphogenetic protein antagonism, a signaling pathw
168 AT reduces cleavage of the hepcidin inducing bone morphogenetic protein co-receptor HJV via inhibitio
169 channels regulate release of the Drosophila bone morphogenetic protein Dpp in the developing fly win
172 GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108)
173 We analyzed the effect of Irf8 on TGF-beta/bone morphogenetic protein pathway-specific genes in DCs
175 /or cocaine due to severe down-modulation of bone morphogenetic protein receptor (BMPR) axis: the ant
176 ce suggests that serotonin, mutations in the bone morphogenetic protein receptor (BMPR) II gene, and
177 e mutations leading to reduced expression of bone morphogenetic protein receptor (BMPR) II, these mut
179 Because decreased expression and function of bone morphogenetic protein receptor 2 (BMPR2) is observe
180 terized by endothelial dysfunction, impaired bone morphogenetic protein receptor 2 (BMPR2) signaling,
182 g displays increased aromatase and decreased bone morphogenetic protein receptor 2 and Id1 expression
183 pproximately 20% concurrence of inactivating bone morphogenetic protein receptor 2 mutations and dela
184 Anastrozole treatment reversed the impaired bone morphogenetic protein receptor 2 pathway in females
185 expression may play a protective role in the bone morphogenetic protein receptor 2 unaffected carrier
186 itable PAH), most often through mutations of bone morphogenetic protein receptor 2, and idiopathic an
187 with hyperactivating mutations of the type I bone morphogenetic protein receptor ACVR1 (Activin type
188 zol-2-yl)benzamide] but not the inhibitor of bone morphogenetic protein receptor dorsomorphin, blocke
189 HT), which is caused by mutations in TGFbeta/bone morphogenetic protein receptor genes, ENG, encoding
190 However, transforming growth factor beta and bone morphogenetic protein receptor II signaling, and hy
191 role of transforming growth factor beta and bone morphogenetic protein receptor II signaling, human
192 ifferential transforming growth factor beta, bone morphogenetic protein receptor II signaling, or car
193 t beta1-integrin directly interacts with the bone morphogenetic protein receptor subunits BMPR1a and
195 erozygous mutations in the gene encoding the bone morphogenetic protein receptor type 2 (BMPR2) are t
196 ith heritable PAH caused by mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene
197 l hypertension with germline mutation in the bone morphogenetic protein receptor type 2 (BMPR2) gene,
198 H (HPAH) is often caused by mutations in the bone morphogenetic protein receptor type 2 gene (BMPR2).
199 despite clinical and molecular similarity to bone morphogenetic protein receptor type 2 mutation-asso
202 duced aggregation; 2) rs11202221, in BMPR1A (bone morphogenetic protein receptor type1A), replicated
205 ranase greatly stimulated chondrogenesis and bone morphogenetic protein signaling as revealed by Smad
207 nal profiling of isolated nail LRCs revealed bone morphogenetic protein signaling favors nail differe
208 eveal a novel role of TCF7l2 in repressing a bone morphogenetic protein signaling pathway that is kno
209 (Wnt), transforming growth factor-beta, and bone morphogenetic protein signaling pathways affect car
210 specific target genes upon Shh, retinoid, or bone morphogenetic protein signaling, and the collocatio
211 aranase is able to stimulate chondrogenesis, bone morphogenetic protein signaling, cell migration, an
213 R/MEK/Erk1/2 signaling and downregulation of bone morphogenetic protein signaling, with negative and
216 showed that loss of PEAT modestly increases bone morphogenetic protein target gene expression and al
217 fferentially expressed genes were related to bone morphogenetic protein type 2 receptor (BMPR2) signa
218 ty of HPAH patients inherit mutations in the bone morphogenetic protein type 2 receptor gene (BMPR2),
219 Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II) si
220 phagy and block lysosomal degradation of the bone morphogenetic protein type II receptor (BMPR-II), m
222 Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II) ge
223 ntiation and new bone formation through WNT, bone morphogenetic protein, and Notch signaling pathways
224 ation of Hedgehog, fibroblast growth factor, bone morphogenetic protein, and Wnt signaling in the gen
225 , Indian hedgehog, fibroblast growth factor, bone morphogenetic protein, and Wnt signaling pathways i
226 ignaling pathways, including Sonic hedgehog, bone morphogenetic protein, fibroblast growth factor, tr
227 niche signalling pathways, specifically Wnt, bone morphogenetic protein, Notch and epidermal growth f
228 about Notch, transforming growth factor beta/bone morphogenetic protein, Ras, mitogen-activated prote
229 e to maintain pluripotency in the absence of bone morphogenetic protein, removal of LIF destabilizes
231 lial growth factor A (VEGFA), interleukin-2, bone morphogenetic protein-10, VEGFC, and 2 (FGF2) were
232 st differentiation promoted and sustained by bone morphogenetic protein-2 (BMP-2) and TGF-beta, respe
233 rently, sustained in vivo delivery of active bone morphogenetic protein-2 (BMP-2) protein to responsi
234 ch as fibroblast growth factor-2 (FGF-2) and bone morphogenetic protein-2 (BMP-2) work synergisticall
236 gulates differentiation of OCs downstream of bone morphogenetic protein-2 (BMP-2)-stimulated osteobla
237 l with a collagen scaffold soaked in saline, bone morphogenetic protein-2 (BMP-2; 200 ng), 1 muM CGS2
238 al and temporal release of recombinant human bone morphogenetic protein-2 (BMP2) and vascular endothe
240 on of mesenchymal stem cells (MSCs), whereas bone morphogenetic protein-2 (BMP2) promotes osteogenic
241 ayer coating carrying as little as 200 ng of bone morphogenetic protein-2 and platelet-derived growth
242 In osteoblasts, CypA is necessary for BMP-2 (Bone Morphogenetic Protein-2)-induced Smad phosphorylati
245 es for hESC differentiated to TB by means of bone morphogenetic protein-4 and inhibitors of activin A
246 fragment was identified to bind to the human bone morphogenetic protein-6 (hBMP6) growth factor and c
247 echanisms involved revealed the induction of bone morphogenetic protein-7 (BMP7) expression, a critic
250 Our objective is to determine circulating Bone morphogenetic protein-9(BMP-9) levels in subjects w
251 l vein forms and expands ventrally through a Bone Morphogenetic Protein-dependent step of collective
252 ilarly, wild-type (WT) animals, in which the bone morphogenetic protein-mothers against decapentapleg
254 ic stress induces p57Kip2 expression via the bone morphogenetic protein-Smad1 and Atm-p38MAPK-Atf2 pa
255 es with sLR11 inhibits thermogenesis via the bone morphogenetic protein/TGFbeta signalling pathway an
257 subgroup of the TGFbeta superfamily are the bone morphogenetic proteins (BMP), but the effects of BM
261 glands are specified by mesenchymal-derived bone morphogenetic proteins (BMPs) and fibroblast growth
270 mbryo is regulated by graded distribution of bone morphogenetic proteins (BMPs) composed of two ligan
275 rcomes the inhibitory effect of lung-derived bone morphogenetic proteins (BMPs) on self-renewal and t
283 anoid cultures, such as those involving Wnt, bone morphogenetic proteins (BMPs), Notch, and Hedgehog
284 ignaling by Sonic hedgehog (SHH) followed by Bone morphogenetic proteins (BMPs), regulate a dynamic e
289 rogeneous, congenital heart diseases, and to bone morphogenetic proteins 7 as an effective treatment
290 hat supplementation of exogenous recombinant bone morphogenetic proteins 7 effectively ameliorates en
292 operate locally (e.g., Wingless/Ints [Wnts], Bone Morphogenetic Proteins [BMPs], and Hedgehogs [Hhs])
293 lated by Sonic hedgehog (Shh), retinoids, or bone morphogenetic proteins in the CNS, we provide evide
294 dysregulated transforming growth factor beta/bone morphogenetic proteins signaling and that this imba
295 ing, and that ligandless activity in the TGF/bone morphogenetic proteins signaling pathway contribute
296 phosphorylation was mediated by SMC-released bone morphogenetic proteins through VE-cadherin and bone
297 ease inhibitor that binds growth factors and bone morphogenetic proteins, has nonsynonymous changes f
298 yelin-forming oligodendrocytes is limited by bone morphogenetic proteins, which constitute one arm of
299 53 activation; THR-184, a peptide agonist of bone morphogenetic proteins; removal of catalytic iron,
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