ライフサイエンスコーパス: bone sialoprotein

1 -regulating endopeptidase homolog), and Bsp (bone sialoprotein).

2 nimal role in mediating the PTH induction of bone sialoprotein.

3 (HA)-binding properties and bone tropism to bone sialoprotein.

4 as Col10, osterix, alkaline phosphatase, and bone sialoprotein.

5 ontain high levels of sialic acid similar to bone sialoprotein.

6 Bone sialoprotein accumulates within bone acidic glycopr

7 veral bone-associated proteins (osteopontin, bone sialoprotein, alkaline phosphatase, type I collagen

8 rkers of osteoblastic differentiation (i.e., bone sialoprotein and osteocalcin) in the preosteoblasts

9 xpression of osteoblast marker genes such as bone sialoprotein and osteocalcin.

10 osteocyte marker), while osteoblast markers, bone sialoprotein and osteopontin, remained unchanged.

11 ndicated that BMP-2 decreased mRNA levels of bone sialoprotein and type I collagen dose-dependently (

12 e increases in the expression of major bone (bone sialoprotein) and cartilage (type II collagen) matr

13 differentiation markers such as osteocalcin, bone sialoprotein, and dentin matrix protein 1 (DMP1) wa

14 ciated with significant reductions in Runx2, bone sialoprotein, and osteocalcin expression, parallele

15 iation markers Runx-2, alkaline phosphatase, bone sialoprotein, and osteocalcin.

16 N-linked glycoproteins) family of proteins, bone sialoprotein, and osteopontin, bound first to a cel

17 the osteogenic markers alkaline phosphatase, bone sialoprotein, and Runt-related transcription factor

18 total NCPs were separated into osteopontin-, bone sialoprotein-, and dentin matrix protein-1-enriched

19 Surprisingly, osteocalcin and bone sialoprotein are also expressed by malignant but no

20 Osteocalcin and bone sialoprotein are the most abundant noncollagenous b

21 ted transcription factor 2 at 7 days and for bone sialoprotein at days 7 and 10 as well as higher OPN

22 sized that the Staphylococcus aureus MSCRAMM bone sialoprotein-binding protein (Bbp) might recognize

23 gulase, exotoxin, Ser-Asp fibrinogen-binding bone sialoprotein-binding protein, fibrinogen and kerati

24 d osteonectin, whereas alkaline phosphatase, bone sialoprotein, bone Gla protein, and collagen II, al

25 Bone sialoprotein (BSP) and apatite co-localize in the e

26 while BP and IGF promoted gene expression of bone sialoprotein (BSP) and OPN.

27 Bone sialoprotein (BSP) and osteocalcein (OCN) markers w

28 DGF-BB or TGF-beta resulted in a decrease in bone sialoprotein (BSP) and osteocalcin (OCN) mRNAs whil

29 n situ hybridization, for gene expression of bone sialoprotein (BSP) and osteocalcin (OCN), and histo

30 Alendronate suppressed the expression of bone sialoprotein (BSP) and osteonectin in both femurs a

31 lecules associated with mineralized tissues, bone sialoprotein (BSP) and osteopontin (OPN), and a cel

32 Bone sialoprotein (BSP) and osteopontin (OPN, ETA-1) are

33 inical correlation between the expression of bone sialoprotein (BSP) and skeletal metastasis of breas

34 nohistochemistry methods were used to detect bone sialoprotein (BSP) distribution in Hyp and WT mouse

35 study to determine the relationship between bone sialoprotein (BSP) expression and osteocalcin expre

36 ted growth and enhanced osteocalcin (OC) and bone sialoprotein (BSP) gene expression in human prostat

37 The bone sialoprotein (Bsp) gene provides an excellent model

38 Expression of the bone sialoprotein (BSP) gene, a marker of bone formation

39 Bone sialoprotein (BSP) has been shown to induce limited

40 llular phosphoproteins osteopontin (OPN) and bone sialoprotein (BSP) have been implicated in biologic

41 linked glycoproteins), osteopontin (OPN) and bone sialoprotein (BSP) in the Galnt1-null mice relative

42 Bone sialoprotein (BSP) is a multifunctional, highly pho

43 Bone sialoprotein (BSP) is a secreted glycophosphoprotei

44 Bone sialoprotein (BSP) is an acidic 301 amino acid prot

45 Bone sialoprotein (BSP) is an acidic phosphoprotein with

46 Bone sialoprotein (BSP) is an extracellular matrix prote

47 conducted in microdot cultures of UMR-106-01 Bone Sialoprotein (BSP) osteoblast cells.

48 ssociated proteins, i.e., osteopontin (OPN), bone sialoprotein (BSP), alkaline phosphatase (ALP), ost

49 aining bone acidic glycoprotein-75 (BAG-75), bone sialoprotein (BSP), and alkaline phosphatase that a

50 runt-related transcription factor 2 (RunX2), bone sialoprotein (BSP), and osteocalcin (OCN) messenger

51 Dentin matrix protein-1 (DMP1), bone sialoprotein (BSP), and osteopontin (OPN) are three

52 ING proteins: full-length osteopontin (OPN), bone sialoprotein (BSP), dentin matrix protein 1 (DMP1),

53 nsfer and expression of osteocalcin (OC) and bone sialoprotein (BSP), genes pivotal to bone matrix fo

54 ion of a mineralized tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial prod

55 levels of mineral-associated genes including bone sialoprotein (BSP), OC, and osteopontin (OPN) in th

56 Proliferating cell nuclear antigen (PCNA), bone sialoprotein (BSP), osteocalcin (OCN), and tartrate

57 ed cementoblast population (OC/CM) expressed bone sialoprotein (BSP), osteopontin (OPN), and OC, mark

58 truct containing the response element of rat bone sialoprotein (BSP).

59 ifferentially expressed gene was found to be bone sialoprotein (Bsp).

60 sociated markers, e.g., osteocalcin (OCN) or bone sialoprotein (BSP).

61 prove this hypothesis, we infected 5-day-old bone sialoprotein (BSP)/avian retroviral receptor gene (

62 ays for core binding factor alpha-1 [Cbfa1], bone sialoprotein [BSP], osteocalcin [OCN], and osteopon

63 s: bone marrow mesenchymal stem cell, BMMSC; bone sialoprotein, BSP; hydroxyapatite/tricalcium phosph

64 ly of integrin-binding phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin mat

65 target genes, osteocalcin, osteopontin, and bone sialoprotein but did not significantly alter Runx2

66 and a significant decrease in expression of bone sialoprotein, characteristics of periodontal ligame

67 o OSE2 preceded increases in osteocalcin and bone sialoprotein expression and this increase in Osf2 b

68 , these results suggest that osteocalcin and bone sialoprotein expression is coordinated and regulate

69 study is to investigate how osteocalcin and bone sialoprotein expression is regulated in prostate ca

70 ed osteopontin and osteocalcin and decreased bone sialoprotein expression was detected within 7 days

71 conditioned medium-mediated osteocalcin and bone sialoprotein gene expression in prostate cancer cel

72 In differentiated MC4 cells, osteocalcin and bone sialoprotein gene expression were both down-regulat

73 evelopment (e.g. Col1a1, Postn/Osf2, and the bone sialoprotein gene or BSP), genes that are expressed

74 transcription factor in the osteocalcin and bone sialoprotein genes that cannot be resolved by tradi

75 ssion of osteoblast-specific osteocalcin and bone sialoprotein genes, alkaline phosphatase activity,

76 g the alkaline phosphatase, osteocalcin, and bone sialoprotein genes, and temporally associates with

77 trix phosphoproteins such as osteopontin and bone sialoprotein have yielded important biological info

78 t differentiation genes osterix (Sp7), Atf4, bone sialoprotein (Ibsp), and osteocalcin (Bglap) withou

79 tein (DSPP), dentin matrix protein 1 (DMP1), bone sialoprotein II (IBSP), and bone morphogenetic prot

80 line phosphatase/ALPL, osteopontin/SPP1, and bone sialoprotein II/IBSP) in a subset of the hMSC popul

81 ne phosphatase), Ocn (osteocalcin), and Bsp (bone sialoprotein) in response to recombinant PP and sta

82 of osteoblastic marker genes, namely Ocn and bone sialoprotein, in Atf4(-/-) developing bones.

83 Bone sialoprotein is a 70-kDa extracellular matrix compo

84 Bone sialoprotein is a major noncollagenous protein of b

85 Similar fragments of bone sialoprotein, like the intact protein, did not func

86 at calcium deposition and gene expression of bone sialoprotein, lipoprotein lipase, and fatty acid bi

87 A1 and osteocalcin mRNA levels and increased bone sialoprotein mRNA, consistent with an inhibition of

88 -fold increase in the steady-state levels of bone sialoprotein mRNAs within primary cultures of embry

89 ophages in response to added native purified bone sialoprotein (nBSP) and its dephosphorylated form (

90 versus normal human valves for osteopontin, bone sialoprotein, osteocalcin, alkaline phosphatase, an

91 educed osterix-producing cells and increased bone sialoprotein, osteocalcin, and BMP-7 expression.

92 vealed increased mRNA levels of osteopontin, bone sialoprotein, osteocalcin, and Cbfa1 in the calcifi

93 parallel, a decreased expression of Runx-2, bone sialoprotein, osteocalcin, and RANK-L.

94 ogenic markers such as Runx2, Osterix, DMP1, Bone sialoprotein, Osteocalcin, NFATc1, and Schnurri-2,

95 ng ligand N-linked glycoproteins (SIBLINGs): bone sialoprotein, osteopontin, and dentin matrix protei

96 g demonstrated that a sizeable proportion of bone sialoprotein particles were located within a 50-nm

97 tion revealed that (a) human osteocalcin and bone sialoprotein promoter activities in an androgen-ind

98 ediated stimulation of human osteocalcin and bone sialoprotein promoter activities occurs through inc

99 um was found to induce human osteocalcin and bone sialoprotein promoter activities via increased CRE/

100 increased or repressed human osteocalcin and bone sialoprotein promoter activities.

101 of an osteoblast-specific element within the bone sialoprotein promoter and demonstrate its regulatio

102 ) Deletion analysis of human osteocalcin and bone sialoprotein promoter regions identified cyclic AMP

103 tronectin, type I collagen, osteopontin, and bone sialoprotein) showed any detectable effect on PG me

104 Bone sialoprotein specifically binds proMMP-2 and active

105 alkaline phosphatase, bone Gla protein, and bone sialoprotein, suggesting an osteogenic phenotype.

106 tein 1, and higher levels of osteopontin and bone sialoprotein than the normal.

107 ble in both genotypes, and the expression of bone sialoprotein was similar in tumor-bearing bones of

108 Bone sialoprotein was the only osteoblast marker strongl

109 tic protein (BMP)-2, BMP-7, osteopontin, and bone sialoprotein were evaluated in alveolar sockets.

110 bone proteins, osteopontin, osteonectin, and bone sialoprotein, were identified in the protein extrac

111 ion factor 2), osteocalcin, osteopontin, and bone sialoprotein, were reduced proportionate to the red

112 n the pro-adhesive molecules osteopontin and bone sialoprotein, which is in contrast to the high leve