ライフサイエンスコーパス: border zone

1 ed post-MI, giving rise to a 'neural sensory border zone'.

2 rimary prevention ICD by quantifying the LGE border zone.

3 proliferation and synaptogenesis in the ICH border zone.

4 arrhythmia susceptibility in the healed scar border zone.

5 ar or mesenchymal stem cells) in LV scar and border zone.

6 M-derived cell incorporation in the ischemic border zone.

7 ce had fewer progenitor cells in the infarct border zone.

8 lood flow (MBF), particularly in the infarct border zone.

9 d increased in vivo proliferation within the border zone.

10 ger in the central ischemic zone than in the border zone.

11 th factor (VEGF), or MSCs +HGF/VEGF into the border zone.

12 animals, rising higher in the MI + MR-group border zone.

13 rcts also had marked TSP-1 deposition in the border zone.

14 on site was consistently located in the scar border zone.

15 types of therapeutic interest in the infarct border zone.

16 the presence of nerve fibers in the infarct border zone.

17 and large sinusoidal vascular canals in the border zone.

18 apoptosis, including myocytes in the infarct border zone.

19 e more viable cardiomyocytes within the scar/border zone.

20 FLT3 ligand (FL) or vehicle into the infarct border zone.

21 f resting perfusion in either the MI core or border zone.

22 gradients in cellular properties across the border zone.

23 e ions and carbon dioxide across an ischemic border zone.

24 increased neovascularization of the infarct border zone.

25 r conduction velocity in the anterior-septal border zone.

26 that were mainly located in the infarct and border zones.

27 cular function observed in either infarct or border zones.

28 in alone (sham) was injected into epicardial border zones.

29 idized fatty acid production in the ischemic border zones.

30 TESI was guided to 10 sites in infarct-border zones.

31 sed the T-tubule integrity at the remote and border zones.

32 tients, with no difference in the transition/border zone (11.4% [Q1-Q3, 9.5%-13.2%] versus 16.6% [Q1-

33 Collagen content increased in the border zone (12+/-2%) and decreased in the remote zone (

34 % CI, -2.78 to 1.34), and wall motion in the border zone (16.0 to 16.6 mm vs 16.1 to 19.3 mm; between

35 re run: (1) single injection to the anterior border zone; (2) therapeutic multiple border zone inject

36 ation of inflammatory cells into the infarct border zone 24 hours after ischemia/reperfusion injury,

37 g factor enhancement pathways in the infarct border zone 24 hours after MI, leading to decreased card

38 69+/-41 478 pixels(2)), intermediate in scar border zone (255 979+/-36 016 pixels(2)), and highest in

39 n of surviving myocardium within the infarct border zone, (4) reduced magnitudes of EGM negative deri

40 re within bipolar voltage-defined scar (7%), border zone (57%), and areas of normal voltage (36%), bu

41 ant, capillary density was 30% higher in the border zone (908.1+/-99.7/mm(2) in control versus 1209.0

42 nctional capillary network at the remote and border zone, accompanied by reduced scar extension, pres

43 a subset of mononuclear cells of the infarct border zone after 5 to 28 days of reperfusion.

44 and cardiac myocyte apoptosis in the infarct border zone after myocardial infarction.

45 tensity, a priori information and a weighted border zone algorithm, were compared with a modified ful

46 opathy (NICM) patients and to evaluate 4 LGE border-zone algorithms.

47 reperfused infarctions consisted of a bright border zone and a less enhanced central core.

48 an important therapeutic target of peri-scar border zone and a promising therapeutic potential for us

49 ak Ecc than did noninducible patients in the border zone and adjacent and infarcted regions (P < .001

50 NA and protein expression in the infarct and border zone and decreased serum SDF-1 levels.

51 ng of the epicardium was also performed, and border zone and dense scar surface area and late potenti

52 c(hi) monocytes infiltrated into the infarct border zone and differentiated into mature Ly6c(lo) phag

53 Mononuclear cells infiltrate the border zone and express IL-6 mRNA.

54 Ratio of Ecc in border zone and in remote regions was greater (P < .05)

55 Larger infarct border zone and its percentage of myocardium were found

56 able T-tubule remodeling near the infarction border zone and moderate LV remodeling remote from the M

57 ), nuclear Yap1 was found selectively in the border zone and not in the remote area of the heart.

58 CBSCs were present in the MI border zone and proliferating at 72 hours post-MI but ha

59 ular potassium was found to have the largest border zone and this was attributed to the voltage depen

60 in-walled, dilated neovessels in the infarct border zone and was accompanied by decreased expression

61 might restore fast conduction in epicardial border zones and be antiarrhythmic.

62 MSCs engrafted in infarct and border zones and differentiated into cardiomyocytes as a

63 and WISP1 expressions were increased in the border zones and non-ischemic remote regions of the post

64 Quantification of core and border zones and their percentages of myocardium through

65 isual characteristics of normal tissue, scar border zone, and dense scar in vivo with the use of a no

66 tissue blocks containing normal myocardium, border zone, and dense scar.

67 Nuclei isolated from healthy, border zone, and ischemic regions of the affected heart

68 ed intensity, a priori information, weighted border zone, and modified full-width half-maximum algori

69 ope was calculated for the MI core, adjacent border zone, and remote myocardium.

70 ions can be described after MI: the infarct, border zone, and remote regions.

71 nce of the VT, 4 originated from an ischemic border zone, and the origin of 2 could not be determined

72 cute infarcts along the internal or anterior border zones, and 2 patients showed microembolic signals

73 in vivo testing, CLG-4 application decreased border zone area (21.3+/-14.3 to 17.1+/-11.1 mm(2), P=0.

74 of the reentrant circuits in the epicardial border zone associated with each morphology indicated tw

75 increase AZ7379 availability in the infarct/border zone at 24h post-injection as compared with free

76 iomyocyte cell cycle activity at the infarct border zone at 4 weeks after permanent coronary artery o

77 d saline; n=5) was injected into the infarct border zones at 14 days after MI.

78 < or = 50% that without repair in remote and border zones at 3 months, and the matrix metalloproteina

79 on) left ventricular function in infarct and border zones at 6 months measured by cardiac magnetic re

80 2 cells were found integrated in the infarct border zones at day 28.

81 hypometabolic and normal cortex (metabolic "border zones") based on interictal glucose PET.

82 (wall motion) LV function in the infarct and border zone between baseline and 6 months, measured by c

83 chronic lesions showed a sharply demarcated border zone between fibrotic and normal myocardium.

84 In the border zone between the middle cerebral artery and the A

85 9 Hz resulted in wavebreak at the interface (border zone) between infected and non-infected regions;

86 g mapping of IMAT, confined to putative scar border zones (bipolar amplitude, 0.5-1.5 mV).

87 n regional contractility in both infarct and border zones (both p < 0.05).

88 contractile function in the infarct zone and border zone (BZ) after coronary artery occlusion.

89 anced-cardiac magnetic resonance (ce-CMR) as border zone (BZ) corridors.

90 e temporal distribution of stress in the LVA border zone (BZ) during systole.

91 saline (control, n=6) was injected into the border zone (BZ) myocardium.

92 ved myocardial substrate categories of scar, border zone (BZ), and normal myocardium regions.

93 ell-treatment group, P<0.05) in the periscar border zone (BZ), which was accompanied by improvements

94 adient of refractoriness across the ischemic border zone (BZ).

95 es targeting these cell types in the infarct border zone can improve cardiac function but are limited

96 mice with recombinant Emc10 enhanced infarct border-zone capillarization and exerted a sustained bene

97 Shh) also reduced infarct size and increased border zone capillary density compared with unmodified C

98 r zone induces multiple local effects in the border zone cardiac myocytes resulting in beneficial ven

99 Notch1 is activated in border zone cardiomyocytes coincident with nuclear c-Met

100 DCs lead to cardiomyocyte hyperplasia in the border zone, consistent with the observed stimulation of

101 l significantly different from the values in border zone cortex, and in cortex contralateral to ische

102 The functional effect of increasing border-zone Cx43 has not been previously evaluated.

103 Results indicate that additions to the border zone decrease end-systolic fiber stress proportio

104 amyocardial injection of FL into the infarct border zone decreased infarct size and ameliorated post-

105 A border zone, defined by the inner limit of the AF vulner

106 was higher (P<0.05), although scar size and border zone did not differ.

107 nts for weak acid (e.g., CO(2)) occur across border zones during regional myocardial ischemia, raisin

108 Mapping of the epicardial border zone (EBZ) indicated that initiation of VT was se

109 Impulse propagation in the epicardial border zone (EBZ) of 4-day-old healing infarcts was mapp

110 The epicardial border zone (EBZ) of canine infarcts has increased aniso

111 ap-junctional distribution in the epicardial border zone (EBZ) of healing canine infarcts define the

112 Reentrant circuits in the epicardial border zone (EBZ) of healing canine infarcts were mapped

113 tricular fibrillation (VF) in the epicardial border zone (EBZ) of hearts with chronic myocardial infa

114 ax in myocytes dispersed from the epicardial border zone (EBZ) of the 5-day infarcted canine heart (m

115 in the remodeled substrate of the epicardial border zone (EBZ) of the 5-day infarcted canine heart.

116 ct Na+ channels of cells from the epicardial border zone (EBZ) of the 5-day infarcted heart different

117 remodeled in cells from the 5-day epicardial border zone (EBZ) of the healing canine infarct.

118 was measured in arrhythmogenic subepicardial border zone (EBZ) tissue overlying the infarct and from

119 tanding of the mechanisms underlying infarct border zone electrogram fractionation may be helpful to

120 In vivo epicardial border zone electrograms were broad and fragmented in sh

121 Border zone electrograms were intermediate in amplitude

122 In vivo epicardial border zones electrograms were broad and fragmented in s

123 volume (approximately 4.5%) reduce elevated border zone fiber stresses from mean end-systole levels

124 erated remodeling and hypertrophy, increased border zone fibrosis, augmented NF-kappaB and p38 mitoge

125 When delivered to the border zones following ischemia-reperfusion injury, ther

126 significant disparities in the width of the border zone for each ionic species, with intracellular s

127 cortex contralateral to ischemic cortex and border zone (for all samples n=60, mean wet weight 2.037

128 ocrystals demonstrated greater protection of border zone fractional shortening at 6 weeks.

129 Microelectrode studies of epicardial border zones from SkM1 showed membrane potentials equal

130 Enhanced border zone function defined as greater Ecc and earlier

131 decreased in culture media-treated rats, and border-zone function was preserved in ESC-treated animal

132 ejection fraction) and regional (infarct and border zone) function.

133 Injection of TGF-beta1 into the lesion border zone greatly reduced infarct bleeding in MO/MP-de

134 In NICM patients, total LGE but not LGE border zone had predictive value for ICD therapy.

135 ish a cellular basis for hyperfluorescent GA border zones, histologic autofluorescence (HAF) was meas

136 l generating a reproducible wound and injury border zone (IBZ) in the LV was used.

137 y of VTs late post-MI arise from the infarct border zone (IBZ).

138 dial injection of 6 mug ephrinA1-Fc into the border zone immediately after permanent coronary artery

139 xyuridine+) myocytes detected at the infarct border zone in fixed tissues.

140 In contrast, the border zone in the KO mice demonstrated a much thicker s

141 nction correlated with less apoptosis in the border zone in those animals that received AdVEGF-165 ex

142 n sites colocalized within LVA in 80% and at border zones in 20%.

143 io at the ventral posterior nucleus-pulvinar border zone indicates that this area is crucial in the p

144 the delivery of GATA4 locally to the infarct border zone induces multiple local effects in the border

145 terior border zone; (2) therapeutic multiple border zone injections; and (3) injection of material to

146 stress may prevent the incorporation of the border zone into the infarct, decreasing infarct size an

147 eceptors decreased in the hippocampus in the border zone ipsilateral to the injury while there was an

148 The myocardial ischemic border zone is associated with the initiation and susten

149 Ventricular infarct border zone is characterized by abnormal cellular electr

150 have an apparent thickening of the anterior border zone; it remains to be established whether this i

151 icular with late gadolinium-enhanced infarct border zone mass (r=0.84, P<0.0001) and with peak tropon

152 re mass was 21.7 g (4.4-45.9 g), and infarct border zone mass was 29.8 g (3.9-60.2 g) (full-width at

153 evious studies suggest that the peri-infarct border zone may be an important arrhythmogenic substrate

154 The infarct border zone may be capable of modulating the healing pro

155 catecholamine handling in the viable infarct border zone may play an important role in ventricular re

156 ndogenous expression of TSP-1 in the infarct border zone may serve as a "barrier," limiting expansion

157 6.0%; interquartile range [IQR], 4.1%-8.0%), border zone (median, 8.4%; IQR, 6.4%-10.2%), and remote

158 ed in alleviation of abnormalities including border zone myocardial perfusion, contractile dysfunctio

159 tein connexin 43 (Cx43) occurs in epicardial border zone myocytes following myocardial infarction (MI

160 In the viable infarct border zone, neuronal vesicular catecholamine storage an

161 al muscle Na(+) channel (SkM1) to epicardial border zones normalizes conduction and reduces induction

162 ed granulocyte infiltration into the infarct border zone occurred in OIM/OIM animals.

163 maps of reentrant circuits in the epicardial border zone of 4-day old infarcted dog hearts with the c

164 -6 mRNA is induced in myocytes in the viable border zone of a myocardial infarct.

165 Cardiac myocytes in the viable border zone of a myocardial infarction exhibited reperfu

166 ed us, in an earlier study, to inject in the border zone of acute infarcts Lin(-) c-kit(POS) BMC from

167 addition, human CDCs were injected into the border zone of acute myocardial infarcts in immunodefici

168 GF)-beta/Smad3 signaling is activated in the border zone of healing infarcts and induces fibrotic rem

169 When injected into the infarct border zone of immunodeficient mice 1 week after myocard

170 Peak Ecc in the border zone of inducible patients (-11.42% +/- 0.46 [sta

171 ned from cloned embryos were injected in the border zone of infarcted mice to induce tissue reconstit

172 oth muscle coverage in the neovessels of the border zone of infarcted myocardium are severely impaire

173 c interstitial fibrosis were analyzed in the border zone of infarcted myocardium.

174 Capillary density at the border zone of ischemic myocardium also was significantl

175 Injection of DNA for VEGF in the border zone of MI in rat hearts induced angiogenesis.

176 When injected into the border zone of mice after acute myocardial infarction, S

177 endothelial growth factor (phVEGF165) in the border zone of myocardial infarct tissue in rat hearts w

178 Human CDCs injected into the border zone of myocardial infarcts engrafted and migrate

179 into the infarct, and there was a continuous border zone of neutrophil infiltration that overlapped a

180 l mapping showed increased activation in the border zone of PPy-chitosan-treated rats.

181 h muscle cells (VSMC) were injected into the border zone of subacute infarcted syngeneic Fischer rat

182 nd capillary density, was observed in the MI border zone of Tbx20(OE) hearts compared with controls.

183 2-isoketals were generated in the epicardial border zone of the canine healing infarct, an arrhythmog

184 Seven days after RF treatment, the border zone of the coagulation zone was surrounded by al

185 gy (mitophagy) were rapidly increased in the border zone of the infarct in wild type mice.

186 s and decreased myofibroblast density in the border zone of the infarct support the beneficial effect

187 tion in reentrant circuits in the epicardial border zone of the infarct was mapped using 192 to 312 b

188 Cells were injected directly in the border zone of the infarcted heart or in corresponding r

189 trant circuits were mapped in the epicardial border zone of the infarcts with a multielectrode array

190 as accompanied by increased apoptosis in the border zone of the MI.

191 expression is down-regulated in the ischemic border zone of the murine left ventricle after MI.

192 early reperfusion is primarily in the viable border zone of the myocardium where myocyte ICAM-1 mRNA

193 ibroblasts, and c-Kit + cells present in the border zone of the remodeling infarct.

194 Late potentials were noted in the border zones of both surfaces of the scar.

195 pectively); 19 +/- 6% CFAE sites occurred at border zones of dense DE.

196 nt) for sIL-1ra, were implanted into infarct border zones of female nude mice immediately after left

197 The function of these channels in border zones of healing infarcts, where arrhythmias also

198 re placed in a linear fashion traversing the border zones of infarcted and normal tissue (mean of 3.4

199 1)In-oxyquinoline and then injected into the border zones of infarcted myocardium of rats.

200 The patients' core and border zones of infarcted myocardium were analyzed and f

201 ere transplanted (n=12) to cover infarct and border zones of recipient rat hearts 1 month after ische

202 Late gadolinium enhancement (LGE) border zone on cardiac magnetic resonance imaging has be

203 release of Fa to and from Cp in the aqueous border zones on both sides of the cell membranes form th

204 dium bound by the scar tissue at the infarct border zone or over the infarct.

205 initiated by extrasystoles arising from the border zone or unidirectional conduction block of paced

206 in MI; P = 0.03), creating a 'neural sensory border zone', or heterogeneity in afferent information.

207 e profile of ionic concentrations across the border zone play a significant role in determining cellu

208 patients with primary prophylactic ICD, LGE border zone predicted ICD therapy in univariable and mul

209 However, the steep APD gradient at the border zone proved to be the primary mechanism of wavebr

210 grammed electrical stimulation of epicardial border zones, QRS duration in cMSC/SkM1 was shorter than

211 y increased capillary density in the infarct border zone, reduced cardiac dilatation, ventricular wal

212 CBSC administration into the MI border zone reduces pathological cardiac structural and

213 In 75 symptomatic patients, cortical border zone-region infarction was found in seven of 36 p

214 No border zone-region infarctions were found in 35 asymptom

215 ssion of early commitment markers within the border zone relative to combinatorial and individual cel

216 uates the effects of gap junction epicardial border zone remodeling (i.e., Gj reduction and Cx43 late

217 ical medicine is whether infarction size and border zone remodeling of the heart can be influenced by

218 In the infarct border zone, SAHA increased autophagic flux, assayed in

219 In the infarct border zone, secretoneurin induced coronary angiogenesis

220 Inducible patients had more infarcted and border zone sectors and a shorter time to peak Ecc than

221 associated neovascularization in the infarct border zone (see the related article beginning on page 1

222 th seizure onset were located over metabolic border zones significantly more frequently than over hyp

223 olar electrograms were acquired from infarct border zone sites in 10 canine heart experiments 3 to 5

224 ession in murine heart tissue in the infarct border zone suggesting that ER stress may play a role in

225 The dynamic cellular response in the border zone surrounding ablation-induced coagulation and

226 ctions may assume clinical importance in the border zone surrounding an infarction, where local prote

227 minally differentiated cardiomyocytes in the border zone surrounding the infarct.

228 and measured as a fraction of the 250-microm border zone surrounding the initial GA lesion.

229 against extension of infarction and improve border zone survival in myocardial infarction.

230 rodes also more frequently overlay metabolic border zones than hypometabolic regions.

231 mic areas, particularly in the inner infarct border zone (the penumbra), of the bid-deficient brains.

232 As a fraction of the geographic atrophy border zone, the mean new GA was 0.44+/-0.20, and the me

233 In the 500-microm border zone, the mean relative PPV of FAF and of proximi

234 In depolarized myocardial infarct epicardial border zones, the cardiac sodium channel (SCN5A) is larg

235 In depolarized myocardial infarct epicardial border zones, the cardiac sodium channel is largely inac

236 by 40% in treated sheep, whereas infarct and border zone thickness were enhanced.

237 h sharp thin-to-thick transitions in infarct border zone thickness.

238 heterogeneity by measuring infarct core and border zones through CMR might have a higher association

239 nalysis was also conducted with a 500-microm border zone to determine the predictive value of proximi

240 Pace-mapping has been used in the scar border zone to identify the exit site of post-infarction

241 on, preserved cardiac function, and enhanced border zone wall thickening, was observed in Akt1(-/-) m

242 /-0.7 versus control 14.4+/-0.4 mm, P<0.001; border-zone wall thickness 1.59+/-0.11 versus control 1.

243 GATA4:VP22 expression in the border zone was associated with increased cardiac myosin

244 The border zone was characterized by paradoxical stimulus cu

245 echocardiography, and sonomicrometry of the border zone was compared with the normal left ventricle

246 ys after MI, MMP-9 expression in the infarct border zone was higher in OIM/OIM than in WT/WT animals.

247 MI, however, capillarization of the infarct border zone was impaired in KO mice, and the animals dev

248 Regularity at the border zone was lowest when rotors resided in the infect

249 -1.8; P=0.03) incorporated into the ischemic border zone was reduced as compared with wild-type (WT)

250 ular tachycardia occurring in the epicardial border zone was used in 54 experiments (25 canine hearts

251 ery thromboembolism with impaired washout at border zones was a common mechanism in stroke recurrence

252 ip, defined as a lead tip positioned on scar/border zone, was determined by overlaying fluoroscopic p

253 ct Cx43 lateralization within the epicardial border zone, we performed Western blot, immunoprecipitat

254 o identify peptides specific for the infarct/border zone, we used in vivo phage display methods and a

255 zed) geometric parameters of the isthmus and border zone were measured from the maps.

256 Remote, adjacent, and border zones were defined according to increasing proxim

257 st-derived inflammatory cells in the infarct border zone, whereas intracoronary BM cell injection pro

258 the medically managed patients had a larger border zone, whereas there was no difference between bor

259 stained multinuclear myotubes were found in border zones, whereas no positive cells were seen in inf

260 moderately enhanced patchy microinfarcts in border zones, which represent different degrees of contr

261 nt ventricular tachycardia in the epicardial border zone with a figure 8 pattern of conduction was us

262 nt ventricular tachycardia in the epicardial border zone with a figure-8 pattern of conduction was us

263 y monomorphic PVCs originating from the scar border zone with preceding PLPs; targeting these PVCs ma

264 was due to intermediate levels of CollBF in border zones within the risk area that had escaped necro

265 ory IL-1 receptor antagonist (sIL-1ra) at MI border zones would specifically attenuate adverse remode