ライフサイエンスコーパス: both

1 based on GDM/GH status (neither, either, or both).

2 RT-QuIC assay on CSF samples, OM samples, or both.

3 roteins showed the same changing patterns in both 1 SL and 2 SL.

4 Here, we show that both 2009 pandemic H1N1 influenza A (H1N1) virus and hig

5 ed compounds with only beta-O-4 linkages, or both 5-5 and beta-O-4 linkages, showed major 1,2-elimina

6 i images compared with whole-body images for both (68)Ga-DOTATOC and (68)Ga DOTATATE.

7 ral properties of ligand binding: we observe both a direct stabilizing effect of ligand-protein inter

8 e of binding sites have been evaluated using both a distance and a volumetric overlap approach.

9 sue from textual metadata and GEO data using both a heuristic approach as well as machine learning.

10 CaMKI is required and serves as both a PINK1 and Parkin kinase.

11 ta depletion resulted in rapid deployment of both a pro-inflammatory and an immunosuppressive respons

12 an abscission and lateral root emergence are both accompanied by cell-wall remodeling, which involves

13 or responses in the inflammatory contexts of both acute infection and chronic autoimmunity in mice.

14 with moderate to severe PS, 10 subjects with both AD and CD, and 10 HC with no history of skin diseas

15 an iterative search process developed to be both agglomerative, to add sequences containing similar

16 n important role in murine asthma, mediating both AHR and mucus secretion after HDM exposure.

17 nduced surface expression of E-selectin, and both ALK1 and ALK2 in the up-regulation of VCAM-1 and IC

18 of IgG1 and IgG3 specific for MSP119, MSP2 (both allelic families, 3D7 and FC27), MSP3, GLURP (both

19 stereoselective route in six steps; however, both alpha and beta epimers could be obtained by a nonst

20 by transfer of radiolabels into product from both alpha and gamma phosphates of donor molecules.

21 with dual activity for effectively blocking both AMPA and kainate receptors.

22 eas their strongly destabilized mutants form both amyloids and nonamyloid aggregates.

23 (ii) Selective and cooperative binding of both an acetato ligand and an amino ligand to zinc occur

24 There appears to be both an anticipatory effect (future targeted procedures

25 PET) and computed tomography (CT) can assess both anatomy and biology of carotid atherosclerosis.

26 Following a single intranasal inoculation, both animal species shed the vaccine viruses for a limit

27 aFeO2.5)1 thin film superlattices possessing both anion-vacancy order and Sr and Ca chemical order at

28 -tetramethyl-1-piperidinol (SA-2) containing both antioxidant and NO donor functionalities that provi

29 n extensive perturbations of the dynamics in both apo- and holo-forms of the HCN4 isoform, reflecting

30 will allow for informed decision making for both apple producers and cider makers.

31 Both are extensions of the Minimum Information about Any

32 These bacteria mineralize both arsenic and barium on intracellular vesicles.

33 YY1 acts both as a repressor and as an activator of gene expressi

34 lls that produce more inflammatory cytokines both at baseline and following endotoxin exposure when c

35 f low GSH levels, we disrupted its synthesis both at birth by breeding a Gclc loxP mouse with a thy1-

36 n between two images in rivalry is driven by both attentional modulation and mutual inhibition, which

37 On the basis of its ability to both attract and induce virulence gene expression in EHE

38 i film are controlled at low concentrations (both B and P are less than 1 ppm).

39 vesicles with lipid compositions that mimic both bacterial and mammalian cell membranes.

40 that PAG microglia are sexually dimorphic in both basal and LPS-induced activation and contribute to

41 ulatory variation in individual yeast cells, both before and after stress.

42 with higher working-age male mortality rates both between 1992 and 1998 (age-standardised mortality r

43 mposite NEI VFQ-25 score was associated with both binocular 24-2 (beta = 1.95; 95% CI, 0.47-3.43; P =

44 The benefits of land sparing for both biodiversity and carbon storage suggest that safegu

45 onary science of culture that is grounded in both biological and evolutionary theory, but also treats

46 We speculate that micromolar H2O2 is created both biologically and abiotically at natural oxic/anoxic

47 Both BioRoot and MTA Fillapex showed cytotoxicity which

48 metry and interact almost symmetrically with both boron atoms.

49 iron concentration than wild-type plants in both brown and white grains.

50 SNF may play a role in both by supplying N to leaf tissues for acclimation and

51 amolecular amidation and the construction of both C-C and C-N bonds.

52 vegetative growth in the wild progenitors of both C3 and C4 founder crops.

53 Moreover, an anion exchange process on both CaAl LDHs was followed by in situ time-resolved syn

54 The study of both cancer-bearing mouse models in wild types and their

55 r protein sorting 34 (Vps34) plays a role in both canonical and noncanonical autophagy, key processes

56 complex ecosystems has been pointed out: in both cases, topological features of network structures i

57 obabilistic category learning performance in both CD and HC.

58 pes in the V3-loop and trimer base, minimize both CD4 reactivity and CD4-induced non-nAb epitope expo

59 Additionally, both CD8(+) T cells and CD8(+) dendritic cells were iden

60 lective T5 cells and to all four subtypes of both cell classes.

61 rganized basement membrane that lies between both cell types.

62 The auxin effector ARF5/MONOPTEROS (MP) acts both cell-autonomously and noncell-autonomously to contr

63 ge-adjusted incidence of HPV-related cancer (both cervical and non-cervical) in all women in England

64 1-ethylbenzimidazolin-2-one (EBIO), activate both channel types with similar potencies.

65 highlights the importance of selecting from both chemo- and biocatalysts for optimal results.

66 The reaction is both chemo- and regioselective, as only 4,6-disubstitute

67 as multipotential progenitors that generate both classes of myelinating cells.

68 provide critical assessments of disease for both clinical and basic science imaging research studies

69 Thus, the ASCC3 gene expresses both coding and non-coding transcript isoforms with oppo

70 Critically, reward devaluation by both cognitive and physical effort was subserved by a co

71 igher odds of daily smoking were observed in both cohorts for those adolescents whose parents separat

72 Patients in both cohorts were adults (>/=18 years in England, >/=16

73 ented SNS and haemodynamic reactivity during both combat-related and non-combat related mental stress

74 nant sequences were shown to be identical in both compartments.

75 In the cerebellum, both compensatory and detrimental contributions seem to

76 This shows that both conformational rigidity and dynamics are essential

77 systems supporting face and voice processing both contribute to the extraction of important informati

78 Considering uncertainty in both cost and effect using a wide range of willingness t

79 s for alkylations has become attractive from both cost and sustainability viewpoints.

80 ows this short motif to be bound directly by both CPSF-30 and WDR33.

81 te tissue types, but existing approaches are both CPU and memory-intensive, limiting their applicatio

82 nalyzed, not statistical differences between both crops were found.

83 similation was greater at elevated [CO2 ] in both cultivars, while stomatal conductance was lower.

84 (CCR6(+)), and particularly those expressing both CXCR3 and CD161 were reduced most significantly, wh

85 Mitotic activation of Gwl requires both cyclin-dependent kinase 1 (CDK1)-dependent phosphor

86 he development of stochastic models that can both deconvolve the stages of polymerase activity and id

87 r is diffusion driven for surface electrons, both diffusion and phonon drag contributions are essenti

88 pounds while other mammals contain PFOS from both direct exposure and precursor degradation.

89 ential and Tafel slope for catalytic HER are both directly correlated with the electron donating stre

90 NSC-370284 and UC-514321 both directly target STAT3/5, transcriptional activators

91 Here, we further stabilized pre-F by adding both disulfide and cavity-filling mutations (DS-Cav1), a

92 es at an average ratio of 29.2% by targeting both DNA strands simultaneously with an over 98.6% cover

93 ders of magnitude in seed size and including both dormant and nondormant seeds.

94 ion causes a severe global health concern to both ecosystem and humanity.

95 Surgery was both effective and cost-effective for obese patients wit

96 nnovative technique for training students in both effective interprofessional communication and manag

97 into colloidal semiconductor nanorods allow both efficient photocurrent generation through a photovo

98 raphene foil is designed and constructed for both electrochemical and photoelectrochemical water spli

99 ent may thus constitute a common endpoint of both EMT-dependent and EMT-independent cancer disseminat

100 f applicability of molecular docking to show both enantioselective electrochemical and photoluminesce

101 utant cells from the tissue, while utilizing both endogenous and ectopic cellular behaviours to disma

102 In both environments, we found that stream sticklebacks wer

103 In both ethnicities, the strongest associations were center

104 1, 2016, to December 30, 2016, and included both eyes of 100 patients with glaucoma or ocular hypert

105 ole of roughness in colloid attachment under both favorable and unfavorable conditions.

106 nd prostate) and lung and colon tissues from both female and male mice.

107 and enthalpies obtained from G4 calculations both find that the resonance stabilization of the two un

108 Both flux decline and membrane scale formation decreased

109 allowing determination of ligand selectivity both for small drugs and large proteins with nearly base

110 produced by different methods is beneficial both for the developers of scaffold assembly algorithms

111 f pathophysiology and important risk factors both for the development of ARDS and for important patie

112 and suicidal ideation improved equally with both formats.

113 r bulbar redness, compared with placebo, for both forms of omega-3 EFAs.

114 ove were comparatively appraised in terms of both functional cohesion and intra-subnetwork associatio

115 In humans, tolerance of the loss of one or both functional copies of a gene is related to the gene'

116 R neurons recruit both GABA and GABA-A receptors to their axon terminals i

117 SEP was associated with higher adult BMI in both genders, and differences were typically larger at o

118 Expression of both genes was elevated in obese mice, and induction of

119 g CVVH there was a substantial net uptake of both glucose and citrate that delivered exogenous energy

120 g in SBMA muscles and induced hypertrophy of both glycolytic and oxidative fibers.

121 disorder during this period were uncommon in both groups (4.2% versus 4.3%).

122 Both groups could receive open-label LAI for 84 addition

123 ristics and hospital courses were similar in both groups, and birth weights ranged from 580 to 1495 g

124 ing total T cells, T-helper and CTLs against both H1N2 and H1N1 SwIV.

125 Therefore, we show that both habit-like attention and goal-directed processes oc

126 ts with distinct immunological properties in both healthy individuals and cancer patients.

127 lasticity, thereby generating varieties with both high mean phenotype values and levels of plasticity

128 nd reproducible and, thus, can be applied to both high-efficiency protein purification and large-scal

129 During pressure overload, both hypertrophic and hypoxic signals can stimulate angi

130 balance underlies obesity and occurs through both hypertrophy of existing cells and increased differe

131 ide significant in a meta-analysis including both identification and 4 verification cohorts (P < 2.19

132 Both imatinib-sensitive and imatinib-resistant Kit (Kit(

133 udies have revealed how editing is regulated both in cis and in trans.

134 hallenge with individual virulent serotypes, both in early challenge and after 5 months of challenge

135 Both in G protein-mediated pathways and in beta-arrestin

136 An unprecedented solvent-directed "switch" both in helical pattern and handedness was observed when

137 rn, exacerbate ethanol-induced liver disease both in mice and humans.

138 by repeated measurements over hours and days both in phantoms and in vivo.

139 induce efficient apoptotic cancer cell death both in vitro and in vivo through tumor-specific (1) O2

140 triggered by a decrease in hDBR1 expression both in vitro and in vivo.

141 r odonto/osteogenic differentiation of DPSCs both in vivo and in vitro.

142 are increasing in epidemic proportions, and both increase the prevalence of cardiovascular disease e

143 was strongly associated with severe malaria, both independently (aOR, 5.58 [95% CI, 2.03-15.36]) and

144 By contrast, if female and male partners are both infected, embryos are viable.

145 the examples resulting from these efforts in both inhibiting and stabilizing specific 14-3-3 protein

146 populations that transmit information about both innocuous and painful touch and inhibitory populati

147 of cognitive reserve is likely essential for both interpreting cognitive outcomes associated with CTE

148 dels in fact well predict observed levels of both intra- and interhost variability.

149 ng the relationship between the vitreous (in both its attached and detached state) and the internal l

150 Both layer and sponge cakes exhibited an enhancement of

151 peptidolipids or lipopentapeptide (L5P), yet both lipids are present in other M. avium subspecies.

152 enables the study of biological processes in both living and nonviable systems at the molecular level

153 The pairing of both loss- and gain-of-function datasets reveals complex

154 an important role in vesicle recruitment in both low- and high-frequency hair cells.

155 ngi enhanced plant nutrient acquisition with both lower and more variable water availability, for ins

156 comprehensive description and expression of both major classes of drug transporters, SLC and ABC, in

157 dysfunction and breathing irregularities, in both male and female mice.

158 er, Ulocladium strains were shown to possess both MAT1-1-1 and MAT1-2-1 genes as observed in homothal

159 Both maternal and cord serum samples were assayed for le

160 Both mechanisms fail in CFTR(-/-) swine, suggesting that

161 NTX and on improving treatment retention for both medications.

162 breastfeeding on the liking of vegetables in both members of the dyad.We conducted a randomized contr

163 For both metabolic distances, we found that the probability

164 was a correlation between NET complexes and both microbiota diversity (P = .009) and dominance of Ha

165 Both models found that antibodies to 5 proteins of the M

166 Both models remained effective after inclusion of older

167 In both mouse and human B cells, BCR ligands that deliver a

168 fect in the BAC-Q72 SCA2 mouse model, and in both mouse models it normalized protein levels of severa

169 Using the Transwell system, both murine and human monocytes sorted with magnetic bea

170 is expressed in reactive cholangiocytes, in both murine models and patients with PSC.

171 hromatin-remodeling enzymes, is required for both myoblast proliferation and differentiation, and the

172 was most common and was predicted best when both N-methyl-D-aspartate receptor-IgG and aquaporin-4-I

173 uch intraplate earthquake localization, with both natural and induced seismicity generally clustered

174 nteractions between cells and biointerfaces, both natural and synthetic.

175 We found substantial derangements in both neuronal excitability and short-term synaptic plast

176 the relative GLP-1 vs glucagon production in both non-diabetic and diabetic islets, suggesting a posi

177 ates essential aspects of Ca signaling under both normal and diseased conditions.

178 o the formation of Ang-(1-7) from Ang II, in both normal conditions and in disease states, remains on

179 larmin family has been expanding in terms of both number and the concept.

180 Both obesity and atrial fibrillation (AF) are increasing

181 Insertion mutations in EGFR and HER2 both occur at analogous positions in exon 20.

182 erization and CRY2-CIB1 hetero-dimerization, both of which have been widely used to optically control

183 ssue and expansion of activated macrophages, both of which occurred prior to changes in body weight,

184 hypoxic signals can stimulate angiogenesis, both of which stimulated SRC-2 expression in vitro Furth

185 umber of neuropeptide signaling systems with both oncogenic and tumour-suppressing roles for cancer p

186 s, and does not require critical coupling at both or at any one of the two coupling regions.

187 Both organic farming and higher in-field plant diversity

188 nd better the immunologic factors underlying both original antigenic sin and negative antigenic inter

189 ugs and selected those reporting results for both OS and PFS.

190 uced in the mild and moderate-severe groups (both p < 0.001); (2) the mean cone-mediated PLR was redu

191 however, higher on the BSD than on the DSD (both P < 0.05).

192 s of abnormal amphibians are associated with both parasite infection and chemical contaminants, but t

193 d during the G1 phase of the cell cycle, but both pathways are active in the S and G2 phases.

194 First, both PD patients and mice with ventral tegmental area (V

195 Although both persistent itch and inflammation are commonly assoc

196 (S34F) can be cumulative in cells exposed to both perturbations-drug and mutation-compared with cells

197 OCT detected progression earlier than VF in both PG and GS/PPG groups.

198 Ab (VHH or nanobody) significantly inhibited both phosphoantigen-dependent and -independent activatio

199 of viral and cellular replication cycles in both photoautotrophic and heterotrophic bacterial hosts.

200 tant role of sulfate in tracer formation via both physical and chemical mechanisms.

201 urvival/death, and cellular metabolism under both physiological and pathological conditions.

202 Solitary perturbations (SPs) localized both poloidally and radially are detected within 100 mu

203 e GM and PCR samples, respectively), whereas both possible IA cases were detected by PCR.

204 eration in the atrophied thymus by utilizing both postnatal TEC-defective (resulting from FoxN1-floxe

205 n a novel delay-based task that incorporates both predictable fluctuations and directional shifts in

206 in the evolution of vocal communication, in both production and perception.

207 fferent bacterial phyla and varies widely in both protein sequence and corresponding crRNA sequence c

208 We found that both proteins co-migrated in native gels in a complex of

209 o the levels of expression of GRP78 and that both proteins interact in the cellular context.

210 For both proteins, the kinetics in nanodiscs shows the chara

211 global scale, with negative consequences for both provisioning and climate regulating ecosystem servi

212 A broad substrate scope is demonstrated for both quinazolinone as well as diaryliodonium triflates.

213 Meanwhile, both RanBP9 and tau levels are simultaneously reduced by

214 Loss of both RECQL5 and WRN severely compromises DNA replication

215 ls in the North Atlantic were accompanied by both reductions in Atlantic Meridional Overturning Circu

216 llelic families, 3D7 and FC27), MSP3, GLURP (both regions, R0 and R2), and AMA1 antigens of Plasmodiu

217 ARID1 proteins are histone demethylases that both regulate normal cell fates during development and c

218 However, the contribution of both regulation mechanisms to oxygen up-regulation likel

219 oach to monitor the position and dynamics of both repetitive and non-repetitive genomic regions in li

220 This platform will greatly benefit both researchers and clinicians for interrogating mechan

221 To study changes in both retinal structure and function during the first mon

222 these proteins depends on interactions with both ribosomal subunits, some portion of 30S and 50S ass

223 role that ACSL6 plays in lipid synthesis in both rodent and human skeletal muscle.

224 Both samples provide XANES spectra that can be overlappe

225 Recent evidence suggests value for both selective drain placement and early drain removal f

226 formation, which play a key role in defining both selectivity and permeation.

227 of the art measurement techniques which are both sensitive and efficient.

228 e association was significant among cases of both severe and mild acute pancreatitis.

229 We found, in acute rat OB slices from both sexes, that inhibitory synchrony is evident in the

230 ng that two copies of VirD4 dimers locate on both sides of the apparatus, in between the VirB4 ATPase

231 Both signaling pathways have been predicted previously u

232 f protein adducts requires ATP hydrolysis at both sites, as does the stimulation of ATM kinase activi

233 s: instead of a quantum wave passing through both slits, we have a localized particle with nonlocal i

234 ls of cooperative binding that is present in both solvents.

235 in glutein-2 and albumin, respectively, for both species.

236 dly computes object representations that are both specific for object identity and robust against ide

237 livery vesicles, controlling liposome shape (both statically and dynamically) is of utmost importance

238 Both strategies lasted more than 500 mosquito generation

239 Both structures provide molecular insights into malonate

240 The results found pointed out that both SW-ASV approaches were suitable and easy-to-use met

241 osulfurization and guanylation could lead to both symmetric and unsymmetric N,N',N''-substituted deri

242 Both TA polymers share a common precursor synthesis path

243 ent a photonic crystal device which performs both tasks simultaneously and is able to couple light at

244 ith probable IA were repeatedly positive for both tests (means of 9.5 and 6.8 positive GM and PCR sam

245 ensitization had significant interactions on both the additive (relative excess risk due to interacti

246 T) methods all predict linear geometries for both the anions and the neutral radicals.

247 types and catalytic mechanisms that showcase both the chemical diversity in natural product biosynthe

248 ithout shock during fear conditioning and to both the CS with shock and CS without shock during fear

249 AtBAG7 has functional roles in both the ER and the nucleus.

250 oughout the dermis and epidermis and control both the functional and reparative capacity of the skin.

251 Both the high-temperature average crystal structure and

252 to create insulin analogs with affinity for both the insulin receptor (IR) and mannose receptor C-ty

253 FP promoted atherogenic lipid metabolites in both the intestine and plasma via altered gut microbiota

254 d from TIRFM image sequences, to account for both the lateral diffusion of molecules at the membrane

255 mulated species ranges shifted northward at both the leading edge (northern boundary) and trailing e

256 However, the optimal solutions depend on both the level of noise and how it impacts a particular

257 dala that receives afferent projections from both the main and accessory olfactory bulbs.

258 san proved to be effective, since it reduced both the matrix effect (from values between -40 and -10%

259 We find that both the N- and C-terminal domains of TTP are involved i

260 We find that both the nature of selection on the influenza genome and

261 Lesions of the RMTg reduced both the number of DA neurons inhibited by, and the dura

262 Both the outward and inward K(+) currents shifted Veq K(

263 This has now been corrected in both the PDF and HTML versions of the article.

264 5.48 +/- 1.76 mum-significantly smaller than both the pixel size (14 mum x 28 mum) and the Airy disc

265 ody palivizumab, which recognizes site II on both the pre-F and post-F proteins, is restricted to pro

266 ition states (DeltaDeltaE(double dagger)) in both the presence and absence of the counterion.

267 ness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathi

268 nal analysis of gene expression to determine both the sequence of lineage choices made by multipotent

269 artite interface between synaptotagmin-1 and both the SNARE complex and complexin.

270 For comparison, both the STP and the STOK techniques were used to genera

271 le thermal expansion of a suspended resistor both theoretically and experimentally and obtained consi

272 st-effective interventions are available for both these common cancers, yet for so many women access

273 g as a deAMPylation enzyme, its activity was both time- and concentration-dependent.

274 Both TmELO genes were expressed at various levels in egg

275 en charged amino acid residues are important both to directly stabilize the A1-GpIbalpha complex and

276 riptional cofactors YAP and TAZ are required both to maintain TA cell proliferation and to inhibit di

277 iRNAs crucial for cell identity by enhancing both transcription and Drosha/DGCR8-mediated primary miR

278 ssociated with increased risk of bleeding in both treatment arms.

279 Both treatments had neutral effects on glucose metabolis

280 Both treatments maintained a good biocompatibility of su

281 In both trials, the proportion of patients who discontinued

282 free survival as well as overall survival in both trials.

283 OS or second neoplasias were observed in in both trials.

284 duce differing outcomes-loss of p53 promotes both tumor initiation and progression; loss of Arf promo

285 rugs already approved by the FDA, can reduce both tumor size and invasiveness and could lead to tumor

286 Although both types of neurons receive direct input from entorhin

287 ty member and principal investigator (PI) as both unattainable and undesirable.

288 exhibited the poorest clinical prognoses on both univariable and multivariable analyses accounting f

289 Our calculations indicate that both UQ and MQ have low redox potentials around -260 and

290 To compare the effects of both variants with known inactive GDP- and active GTP-bo

291 nal endothelium and coordinate the timing of both vascular pruning and barrier maturation.

292 r 20-hydroxyeicosatetraenoic acid, which has both vasoconstrictive and natriuretic actions.

293 nonredundant subunits of mTORC1, mTORC2, or both, we showed that mice lacking mTORC1 or mTORC1/mTORC

294 -) mice display abnormal fat accumulation in both white and brown adipose tissues, glucose intoleranc

295 tation (Gfap(R236H)(/+)) (and thus expresses both wild-type and mutant protein).

296 We then compared trajectories through maps both with and without high-order epistasis.

297 ation and that client interactions can occur both with and without oligomer dissociation.

298 umomab group than in the chemotherapy group, both with respect to complete remission with full hemato

299 Megalin expression was about the same in both WT and KO mouse visceral yolk sac, brain, and spina

300 rkably, most show evidence for divergence in both yeasts.