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2 ress or exposed to elevated cortisol stress, both of which activate glucocorticoid receptor signaling
3 of which can be modulated by histidine, but both of which affect sensitivity to important anti-HAT d
4 e Na(+)/K(+) pump, balanced by an h-current, both of which affect the gating of the Na(+) current.
5 ntemporary atmospheric reservoir of 4.57 Gg, both of which agree well with observational constraints.
6 that the HIV-1 CA mutations N74D and A105T, both of which allow escape from inhibition by MX2 and th
7 rcation diameter and decreased aortic taper, both of which also associated with abdominal aortic calc
8 by religion and culturally imposed monogamy, both of which also find parallels among social insects.
9 ng from metabolic inflammation and genetics, both of which alter the immune responses of the host.
10 nes products, PI3-kinase p110delta and SKAP, both of which appear to play a significant role in the d
11 red to differentiate between the two models, both of which are able to reproduce firing rates, oscill
13 ethylglyoxal (MG) and ammonium sulfate (AS), both of which are abundant in the atmospheric environmen
14 In Alzheimer's disease (AD) and epilepsy, both of which are accompanied by recurrent seizures, the
16 A termini wrapping and tetramer positioning, both of which are affected heavily by changes in the phy
19 UUR)) or with mutations in the mt-tRNA(Ile), both of which are aminoacylated by Class I mt-aminoacyl-
21 etion as well as intrinsic oxygen vacancies, both of which are apparently filled by water species.
22 lude gestational diabetes and pre-eclampsia, both of which are associated with long-term morbidities
23 implicated in anxiety and reward processing, both of which are associated with obsessive-compulsive d
24 n genes involved in adhesion and metabolism, both of which are at the core of biofilm development.
25 ulation of tumor glycolysis by EGFR and HIF, both of which are attractive molecular targets for use i
26 y compatible with the MetaPathways pipeline; both of which are available on GitHub with installation
27 tion in the subiculum and perirhinal cortex, both of which are brain regions required for normal NOR.
28 consists of a boundary and a fluid interior, both of which are built from identical rotating spinners
29 iocyanate and photoactivatable azido groups, both of which are capable of covalent attachment with th
30 o orthologs of Eco1, called Esco1 and Esco2, both of which are capable of modifying Smc3, but their r
31 GULATION 5) and NDH (NAD(P)H dehydrogenase), both of which are central players in cyclic electron tra
32 s study, we identified two ligands for KstR, both of which are CoA thioester cholesterol metabolites
34 ion with DNA or inhibition of topoisomerase, both of which are common modes of action for polycyclic
35 to free gamma-amino acids and gamma-lactams, both of which are common structural motifs found in drug
36 of Lewy bodies and Lewy neurites in the CNS, both of which are composed mainly of aggregated alpha-sy
37 eptors, immobilized and diffusing receptors, both of which are confined to post-synaptic elements.
38 ntimate contact with water and soil systems, both of which are considered sinks for NPs accumulation.
39 s, despite a large expansion in genome size, both of which are consistent with what is seen in Tuber
40 irruption modes (North-South and West-East), both of which are correlated with climate variability.
42 to two characterized receptors in honeybees, both of which are coupled to intracellular cAMP pathways
43 ctate-quinone oxidoreductases (Mqo and Lqo), both of which are critical during NO-stress for the comb
44 the antiviral state and autophagy response, both of which are critical factors for survival followin
45 ic acid and C-terminal cholesterol moieties, both of which are critical for their correct function an
46 pressure and for nonreplicating persistence, both of which are critically important aspects of M. tub
47 r knowledge of functional brain development, both of which are critically important to move the brain
50 ified invariant guanine-48 and a Mg(2+) ion, both of which are directly coordinated to the non-bridgi
51 oter sequences of the BCL-2 and k-RAS genes, both of which are dis-regulated in many human pancreatic
52 vip1-1 cells had reduced InsP7 and InsP8, both of which are dynamically modulated in wild-type cel
53 ve recognition probe of sialylation product, both of which are encapsulated in a liposome vesicle for
55 te expression of GFAP and secretion of VEGF, both of which are essential for maintaining astrocyte an
56 tion of both winter coldness and snow depth, both of which are expected to decline with climate chang
59 d with a lattice-expanding phase transition, both of which are facilitated by absorption of the infra
60 rlattice and n-type delta-doped Bi2Te3-xSex, both of which are grown heteroepitaxially using metalorg
61 hormone (FSH) and luteinizing hormone (LH), both of which are heterodimers specified by unique beta
62 rmation of caspase-9 homo- and heterodimers, both of which are impacted by cleavage and contribute to
64 y induced inflammation and oxidative stress, both of which are implicated in the pathogenesis of most
66 capture misinterpretations or task effects, both of which are important aspects of comprehension per
67 ote cellular survival and prevent apoptosis, both of which are important drivers of tumorigenesis.
68 vated p38 and c-Jun N-terminal kinase (JNK), both of which are important for mitogen-activated protei
69 ds (DFAs) with left ventricular dysfunction, both of which are improved by modest weight loss over 1
70 counting, lasted 74 and 27 yr, respectively, both of which are in excellent agreement with that of th
73 fatty acid hydroperoxides and peroxynitrite, both of which are involved in host-pathogen interactions
74 and enhancing cytotoxic NK cell activation, both of which are key outcomes in HIV-1 eradication ther
75 ed intrahepatic triglyceride (IHTG) content, both of which are key risk factors for diabetes and card
76 of hydrogen peroxide and protease function, both of which are known activators of wound-induced tran
78 in (DCX) domain and a TPPP/P25-alpha domain, both of which are known modulators of tubulin polymer st
79 nxiety and acutely altered bodily sensations-both of which are known to be associated with insular fu
80 cluster, which encodes miR-200c and miR-141, both of which are known to post-transcriptionally downre
81 oral bleaching events and disease outbreaks, both of which are linked to anthropogenic climate change
82 lysis, as well as the Abeta42/Abeta40 ratio, both of which are linked to the progression of Alzheimer
84 distinct degradation elements within alpha2, both of which are necessary for alpha2 recognition speci
85 zation and long spin-lattice relaxation time-both of which are necessary for future clinical investig
87 mall catalytic and large accessory subunits, both of which are necessary for RNA primer synthesis.
90 ling intermediates C/EBPbeta and HIF-1alpha, both of which are necessary in macrophage-mediated infla
91 at protect its clock from such disturbances, both of which are needed to fully insulate it from the c
93 dynamics of the Mg(2+)-bound and apo states, both of which are populated, at least transiently, at re
94 elta(12,14)-prostaglandin-J2 and lipoxin A4, both of which are potent inflammation-resolving molecule
95 5alpha (RhT5) and TRIM-cyclophilin A (TCyp), both of which are potent restrictors of HIV-1, could enh
96 OO, with two inorganic acids, HCl and HNO3 , both of which are present in polluted urban atmospheres.
97 cy of infections and the risk of overweight, both of which are prevalent health problems among childr
98 t time in young, ambulant patients with DMD; both of which are primary outcome measures in clinical t
101 iological mechanisms underlying trans-eQTLs, both of which are relevant for understanding susceptibil
102 t movement of alleles into new environments, both of which are relevant to studies of genetic epidemi
103 tial frequency (SF) and phase relationships, both of which are represented locally at the earliest st
106 TCF4 comprises two transcriptional isoforms, both of which are required for optimal pDC development i
107 ed-Coil, and ZYG-8/Doublecortin-Like-Kinase, both of which are required for regenerative growth cone
108 at least two alleles in this initial locus, both of which are required for resistance on a susceptib
109 e (DA) transmission and synaptic plasticity, both of which are required for reward and motor learning
110 coordinates the attenuation of beta-catenin, both of which are required to execute the osteoclast dev
111 debt and also to exaggerated pain responses, both of which are rescued after restoration of normal sl
112 ads to attention deficits and hyperactivity, both of which are rescued by pharmacological augmentatio
113 reduces colonic butyrate and HIF expression, both of which are restored by butyrate supplementation.
114 (PrL), as well as depression-like behaviors, both of which are reversed by selective serotonin reupta
115 and translation of nuclear encoded proteins--both of which are shown to disrupt mitochondrial proteos
116 rates and crustaceans express two dsx genes, both of which are shown to lack alternative splicing.
117 often linear splitting with magnetic fields, both of which are signatures of the Kondo effect in quan
118 Schmallenberg virus (SBV) in Great Britain, both of which are spread by Culicoides biting midges and
119 symptoms of social withdrawal and anhedonia, both of which are strongly modulated by endogenous opioi
120 rences in activities of the IRAP inhibitors, both of which are structurally very similar, but differ
121 s a comprehensive experimental archive file, both of which are suitable for submission with publicati
122 nduced glycolysis and glutamine anaplerosis, both of which are survival responses of cells against mi
123 ion and biofilm formation in this bacterium, both of which are thought to be important for disease pr
127 egions: the mushroom body, the lateral horn (both of which are well known centres for sensory process
128 the use of transplantation or home dialysis, both of which are widely considered preferable to in-cen
129 ologic challenges and environmental insults, both of which associate with changes in epigenetic silen
130 Ydr109c protein and its human homolog FGGY, both of which belong to the broadly conserved FGGY famil
131 ne domain and a unique non-chemokine domain, both of which bind GAGs and are critical for GAG-depende
132 ) and Bro1p (ALIX) ESCRT-associated protein, both of which bind to the viral p33 replication protein,
133 linked to sleep and traumatic brain injury, both of which can affect the progression of migraine.
134 sion and the expanding Ds transition region, both of which can alter the distribution of Ft-Ds hetero
137 rial pH and a decline in membrane potential, both of which can be rescued by adding exogenous cytc.
138 ed AGEs formation and tumour growth in vivo, both of which can be reversed using a MG scavenger.
139 nance responses and local field enhancement, both of which can be tuned through the size and shape of
141 eographic variation in species interactions, both of which can contribute to diversification of plant
142 (S1-NTD) and the C-terminal domain (S1-CTD), both of which can function as receptor-binding domains (
143 atterns of adaptation or demographic change, both of which can have profound influences on future hea
144 programmed death-1 (PD-1) immune checkpoint, both of which can increase tumor-infiltrating lymphocyte
145 e, and phenolics) and geographical distance, both of which can influence the richness and composition
146 ns and introduce large sequence differences, both of which can result in significant structural and f
148 ved with rearrangements of FLT3 or ABL1 (eg, both of which commonly partner with ETV6), and further i
150 te tomography and the strict Bell-CHSH test, both of which confirm a high level of on-chip entangleme
151 feed streams are natural river and seawater, both of which contain not only monovalent ions but also
152 ing inverted repeats and inversion variants, both of which contradict the basic single-orientation as
155 f nitric oxide (NO) and nitrous oxide (N2O), both of which contribute to the harmful environmental si
156 e density of filament arrays in Arabidopsis, both of which correlate with host disease symptom develo
158 ations, phosphorylation and ATP/GTP binding, both of which could affect their transcriptional activit
159 t IL-7/IL-7R pathway dysfunction in T cells, both of which could be associated with C-IRIS immunopath
160 rmostability as shown by circular dichroism, both of which could be restored upon addition of defined
161 gy homeostasis as well as adrenergic stress, both of which could contribute to biased outcomes in mur
162 pital exposure in June 2014-July 2014 (70%), both of which declined after interventions were put in p
163 ment to the swimming stage (small egg size), both of which decrease the amount of time offspring spen
164 en probability time and membrane expression, both of which define ENaC activity, following addition o
169 g regulates the expression of Dlx5 and Hmx3, both of which encode transcription factors essential for
170 lude ticarcillin-clavulanate and ampicillin, both of which enrich for a large number of overlapping A
171 iformes) and a clade of mammals (Carnivora), both of which exhibit substantial craniofacial diversity
172 al3)R30 degrees reconstructed Ag on Si(111), both of which exhibit the parabolic energy-momentum disp
173 ve and in the YAC128 and BACHD mouse models, both of which express a copy of the human HTT gene.
174 lization are overfishing and eutrophication, both of which facilitate enhanced growth of fleshy algae
175 e absence or presence of DOM or glutathione, both of which form strong complexes with Hg via thiol-fu
176 transcriptional regulators, NSP1 and DELLA, both of which function in preceding phases of the symbio
177 Markov models (HMMs) or transducer theories, both of which give the indel component of the probabilit
178 sis of ALD and heterozygote female carriers, both of which groups were compared with age-matched cont
180 C-C coupling, identifying two active sites, both of which have an under-coordinated surface square s
181 the polarized nature of the carbonyl group, both of which have been analyzed through multidimensiona
182 cavities and photonic crystal microcavities, both of which have been developing rapidly over the past
183 and [Cu(II)(carb)3](-) (carb = carbazolide), both of which have been identified under coupling condit
184 phin-Associated Glycoprotein Complex (DAPC), both of which have been linked to muscular dystrophies.
185 enerate linear Ub chains), HHARI and TRIAD1, both of which have been recently demonstrated to work to
187 erization and CRY2-CIB1 hetero-dimerization, both of which have been widely used to optically control
188 hile PH207 is a founder of Iodent germplasm, both of which have contributed substantially to the prod
189 blood eosinophil count and serum periostin, both of which have demonstrated utility in identifying p
190 reme than those in Ashkenazi Jews and Finns, both of which have high rates of recessive disease due t
191 el equivalent) during the last deglaciation, both of which have implications for interpreting geodeti
193 synthesized tubes and uncontrolled bundling, both of which have prevented nanotubes from reaching the
194 e ranked first and forty-fourth respectively both of which have previously been associated with flesh
196 me immune rejection and poor islet function, both of which hinder the success of islet transplantatio
198 icidal activity and reduced oxidative burst, both of which improved in the presence of rhIFN-gamma bu
199 ly and disrupts mTORC2-robosome association, both of which inactivate mTORC2 leading to inhibition of
200 ure to prostaglandin I2 (PGI2) or forskolin, both of which increase platelet cyclic adenosine monopho
201 x ratio was increased by more than 2.5-fold, both of which indicate substantial uncoupled transport.
202 combinant C-termini of ADAMTS10 and ADAMTS6, both of which induce focal adhesions, bind heparin and s
203 be categorised by population and indication, both of which influence the balance between benefits and
207 a potential ceiling effect for item recall, both of which likely contributed to the observed treatme
208 read and in virus assembly in the cytoplasm, both of which likely depend on specific interactions wit
209 heme or with an inflexible placement scheme, both of which limit the ability of the mapper in selecti
211 ributed to two climate-sensitive mechanisms, both of which may also cause changes in water chemistry:
212 cted by succession and soil parent material, both of which may exert independent influence over soil
213 exert dual anxiolytic and anxiogenic roles, both of which may have implications in the area of anxie
214 new disease beyond the intervened segments, both of which may jeopardize patency and lead to recurre
215 with the eradication of Helicobacter pylori, both of which might alter the oesophageal microbiota.
216 ferase Rtt109 and the cullin subunit Rtt101, both of which modify histone H3 that is associated with
217 t two distinct temporal phases of dispersal, both of which most likely emanated from the Near East.
218 patients usually have fatigue and pruritus, both of which occur independently of disease severity.
219 ine formylation and methionine sulfoxidation both of which occur with nearly 100% yield under atmosph
221 and activation of the Chk1 effector kinase, both of which occurred in the absence of detectable DNA
222 ssue and expansion of activated macrophages, both of which occurred prior to changes in body weight,
224 on between p53-regulated metabolism and DDR, both of which play crucial roles in tumor suppression.
225 modulates neuronal and immune cell function, both of which play key roles in pain, therapeutics targe
227 brain hypoxia and subsequent hyperglycemia, both of which precede slower changes in brain temperatur
228 as well as blocking chromophore aggregation, both of which prevent the typically observed bathochromi
229 oskeletal rearrangement at the leading edge, both of which processes are early signaling events neces
231 by reacting 2-MP with 4-OPA or limonene SOA, both of which produced BrC with absorption bands at 475
232 her cell walls within a mucilaginous matrix, both of which progressively dry before sporophyte dehisc
233 ation and endoplasmic reticulum (ER) stress, both of which promote metabolic disease progression.
234 transmembrane domains IV and V and I and II, both of which provide key interfaces for D3R dimerizatio
235 both Au and Pt microwire working electrodes, both of which provided similar sensitivity (ca. 0.2 mM(-
236 oteases and in the immune complement system, both of which react with the ligand only after the thioe
237 acid and 2-hydroxy-imino phenylpyruvic acid, both of which reduced polyposis by more than half compar
239 1, genes not previously associated with PTB, both of which regulate processes clearly relevant to bir
240 1 (HK1) and lactate dehydrogenase A (LDHA) - both of which regulate the metabolic switch - and knockd
242 s, such as biosensors, or cellular delivery, both of which rely heavily on robust and reproducible bi
243 ed astrogliosis or malignant transformation, both of which render the inhibitory neurotransmitter GAB
244 ned group of VapBC toxin/anti-toxin systems, both of which represent toxicity mechanisms that potenti
245 cytosis and targeting by autophagy proteins, both of which require many of the same proteins that med
246 thy or clinically significant macular edema, both of which require timely intervention to preserve vi
247 observed, and in the motor rotational bias, both of which scale with the osmotic shock magnitude.
248 and, more recently, to increase healthspan, both of which seek to extend the healthy period of life
250 yl rings and enriched with polar -OH groups, both of which serve as strong adsorption sites for polar
251 ilial and sporadic Parkinson's disease (PD), both of which share pathogenetic and neurologic similari
253 or patients taking care of their own health--both of which showed a small improvement in initiative p
254 cluding the iodide transporters Nis and Pds, both of which showed enhanced GLIS3 binding at their pro
256 However, whether IL-1alpha or IL-1beta, both of which signals through IL-1R, instigates skin inf
257 es and across the surfactant-oil interfaces, both of which span only a few nanometers, are efficient.
258 ere rotational position and user experience, both of which still resulted in a COV of less than 4% at
259 trand and by the processivity factor Spt4/5, both of which stimulate transcription processivity.
260 hypoxic signals can stimulate angiogenesis, both of which stimulated SRC-2 expression in vitro Furth
261 veraging or single point-probing approaches, both of which suffer from information misinterpretation
262 condition with reduced cardiac muscle cBIN1, both of which support cBIN1 release in MPs from human he
264 and transcription activator-like effectors, both of which target through protein-DNA interactions (1
265 applied to two well-characterized aptamers, both of which undergo conformational changes upon bindin
266 a tetra-coordinate (8-B-4) boronate complex, both of which undergo transmetalation leading to the cro
268 ffusion-based methods, BirgRank and AptRank, both of which use PageRank to diffuse information on thi
269 ves and an accompanying increase in itching, both of which were abolished in the absence of eosinophi
270 thelial function (P<0.01) in wild-type mice, both of which were abrogated in Tcrdelta(-/-) mice (P<0.
272 d in increases in proinflammatory mediators, both of which were attenuated by administration of STAT1
273 bly and a [Pd4L(B)8](8+) box-like structure, both of which were characterized by X-ray analysis.
274 curacy and precision of our NeuCoDIA method, both of which were comparable to our established MS(1)-b
276 This statement updates the 2005 iteration, both of which were developed by the American Heart Assoc
277 hydroxide ions to sites on the cage surface, both of which were established by competition experiment
279 ung vascular permeability and water content, both of which were further exacerbated by endotoxin-medi
280 s (72.7%), followed by A. fusispora (27.3%), both of which were isolated mostly from respiratory spec
281 tosis and systemic insulin hypersensitivity, both of which were largely abolished upon FGF21 knockdow
282 tive oxygen species and necrotic cell death, both of which were mitigated by ATF6 overexpression.
283 tive oxygen species and necrotic cell death, both of which were mitigated by ATF6 overexpression.
284 parasitaemia and 10% P. falciparum, by qPCR, both of which were predominantly sub-microscopic and asy
285 d S-gamma-glutamylcysteine (S-gamma-GluCys), both of which were present at lower levels in subjects e
286 ion and loss of tyrosine-15 phosphorylation, both of which were prevented in cells overexpressing HSP
287 Confederate race and socioeconomic status, both of which were randomized, are shown to interact suc
289 histone H3 acetylation and phosphorylation, both of which were required for NA-induced boosting of L
290 d in beta2AR knockout (KO) bone marrow (BM), both of which were rescued by beta2AR reexpression.
292 e and positively associated with wind speed, both of which were retained in models as a significant p
293 mia and impaired the recovery of blood flow, both of which were reversed by ANG-(1-7) in both models
294 7.2 x 10(-6)) loci in the discovery cohort, both of which were robustly replicated in our independen
296 the expression of two SRSF2-targeting miRs, both of which were shown to repress translation of speci
297 cell growth and defects in cell morphology, both of which were suppressed by overexpressing the LPS
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