ライフサイエンスコーパス: brachyury

1 ops (nodal) and schmalspur, but not no tail (brachyury).

2 at express the pan-mesodermal gene, no tail (Brachyury).

3 expression of mesoderm markers, including T (Brachyury).

4 idates for direct transcriptional targets of Brachyury.

5 overlap with those of several Wnt genes and brachyury.

6 have screened for downstream target genes of Brachyury.

7 may assist in the search for target genes of Brachyury.

8 of other genes compensating for the loss of Brachyury.

9 sis of tumor cells expressing high levels of brachyury.

10 s mediated by a key developmental regulator--Brachyury.

11 types produced by loss of the conserved gene brachyury.

12 d the pan-mesodermal expression territory of Brachyury.

13 e that hypoxia accelerates the expression of Brachyury (a mesoderm-specific transcription factor), BM

14 Gli2 directly induces brachyury, a gene required and sufficient for mesodermal

15 Brachyury, a member of the T-box gene family, is require

16 ressed betaH1 and beta major globins but not Brachyury, a mesodermal marker.

17 in mesoderm differentiation and induction of Brachyury, a transcription factor essential for mesoderm

18 pression, we demonstrate that high levels of brachyury also significantly reduce the susceptibility o

19 subpopulation of mesoderm that co-expresses brachyury (also known as T) and Flk-1 (also known as Kdr

20 positive feedback loops, GATA factors, SoxB, Brachyury and a previously underemphasised role for beta

21 t signalling, while high-level FGF maintains Brachyury and can induce ectopic CNH-like cell foci.

22 ts, Notch, and transcription factors such as brachyury and caudal.

23 rved DNA-binding motif originally defined in Brachyury and characteristic of the Tbx family of transc

24 neural factor Sox2 and the mesodermal factor Brachyury and differentiate into neural and paraxial mes

25 reconstitution with WT Shp-2, expression of brachyury and flk-1 and differentiation to hemangioblast

26 pression of the primitive streak (PS) marker brachyury and Flk-1.

27 use embryos have shown that co-expression of Brachyury and FoxA class transcription factors is requir

28 vidence of a synergistic interaction between Brachyury and FoxA in the activation of an individual no

29 expressed by the endoderm downstream of the Brachyury and FoxA transcription factors in the endomeso

30 Here we show that the genes brachyury and goosecoid are expressed in association wit

31 in the second wave of expression, including Brachyury and Mixer, contribute to the regulation of gen

32 sults in a similar motif to that of metazoan Brachyury and other T-box classes.

33 s an amino acid motif similar to a region in Brachyury and Pax9 transcription factors.

34 mong a subfamily of T-box proteins including Brachyury and Tbx10, and among additional nuclear protei

35 wo T-box transcription factors-No tail (Ntl)/Brachyury and Tbx16/Spadetail-cooperatively regulate an

36 Loss-of-function studies of mouse Brachyury and the zebrafish Brachyury ortholog Ntl indic

37 , indicating a potential association between Brachyury and tumor progression.

38 pilin-1 (NRP-1) coincides with expression of Brachyury and VEGFR-2 and identifies endothelial precurs

39 oposed correlation between the expression of Brachyury and Wnt3, two genes reported as expressed radi

40 no tail (Brachyury) and floating head (Xnot) encode putative tran

41 lated in mouse ES cells by the binding of T (Brachyury) and STAT3 to an enhancer element in the mouse

42 lysis and the examination of sonic hedgehog, Brachyury, and HNF-3 beta gene expression.

43 so known as Kdr), c-Kit, and Nkx2-5, but not Brachyury--and subsequently expressed Isl1.

44 Finally, Brachyury appears to be an excellent marker for the prog

45 Some of the endodermal genes that respond to Brachyury are cytoskeletal modulators that may play a ro

46 itional colonies indicated that they express Brachyury as well as flk-1, SCL/tal-1, GATA-1, (beta)H1

47 nic analysis of the T promoter identifies T (Brachyury) as a direct transcriptional target of the Wnt

48 RNA population from embryos that mis-express brachyury at a stage just prior to the normal onset of e

49 sequence population from embryos expressing brachyury at its peak stage of expression was subtracted

50 ors uniquely establish their own niche--with Brachyury being essential for creating a domain of high

51 show that TBX5 binds to the full palindromic Brachyury binding site and to the half-palindrome, where

52 We find that Tbx3 binds the canonical Brachyury binding site as a monomer and represses transc

53 Mga binds the preferred Brachyury-binding sequence and represses transcription o

54 ts that if the target gene contains multiple Brachyury-binding sites it will be activated early in de

55 to the E2F-binding site but also to Myc- and Brachyury-binding sites.

56 reporter genes containing promoter-proximal Brachyury-binding sites.

57 ne invertebrate, an essential protein called Brachyury binds to specific sites in its target genes.

58 led distinct sequence signatures enriched in Brachyury-bound enhancers.

59 Markers of the early body axis, Brachyury (BRA) and FOXA2, usually showed a concentratio

60 date embryos, the T-box transcription factor Brachyury (Bra) is required for specification and differ

61 of the embryo and consequently tail length: Brachyury, Brachyury the second, and the t-complex tail

62 ic background, such as that of Black and Tan Brachyury (BTBR) mice (a previously reported autism mode

63 The black and tan, brachyury (BTBR) mouse strain with leptin deficiency (Le

64 as identified some direct genomic targets of Brachyury, but little is known about Brachyury targets i

65 in no binding site can still be activated by Brachyury, but only indirectly by an earlier Brachyury-d

66 solution chromosomal localization mapping of Brachyury by ChIP sequencing and ChIP-exonuclease reveal

67 While the T-box transcription factor Brachyury (called No Tail in zebrafish) is a key mediato

68 developmental expression patterns of Notch, brachyury, caudal, and eight Wnt genes have now been det

69 e development, and mis-expression of Xenopus Brachyury causes ectopic mesoderm formation.

70 tion of cells generated from activin-induced brachyury(+) cells to the kidney capsule of recipient mi

71 ains functional binding sites for both Ciona Brachyury (Ci-Bra) and FoxA (Ci-FoxA-a).

72 We found that Ciona Brachyury (Ci-Bra) controls most of its targets directly

73 re recently used to identify potential Ciona Brachyury (Ci-Bra) target genes.

74 pstream of the known enhancer that regulates Brachyury (Ci-Bra), a key determinant of notochord speci

75 otochord-specific transcription factor Ciona Brachyury (Ci-Bra).

76 ed an 8 bp core sequence that is part of the Brachyury consensus-binding site.

77 Here we employ a hormone-inducible Brachyury construct and subtractive hybridization to sea

78 Use of the T (brachyury)-cre line led to Fgfr1 inactivation in all lim

79 pment including somite formation, we used T (Brachyury)-Cre mouse line to inactivate Dicer in most ce

80 hat the stromal cells express proteins (Scl, brachyury, Csf-1R, Gata-1, Flk-1, and Tie-2) that charac

81 Brachyury, but only indirectly by an earlier Brachyury-dependent gene product, so later than the dire

82 evolutionary comparison unveiled a detailed Brachyury-dependent gene-regulatory network that directl

83 Here we demonstrate that Xenopus Brachyury directly regulates expression of eFGF by bindi

84 ing site and to the half-palindrome, whereas Brachyury does not bind to the TBX5 site.

85 o carry out a systematic characterization of Brachyury-downstream notochord CRMs.

86 embryo, thereby providing insights into the Brachyury-driven genetic regulatory network and allowing

87 ntify genes that are expressed downstream of brachyury during gastrulation of the sea urchin embryo.

88 on, we show that the only essential role for Brachyury during somite formation is non-cell autonomous

89 homologs, suggesting that the specificity of Brachyury emerged at the origin of Metazoa.

90 is of en route cell populations by utilizing Brachyury, Etv2, or Scl reporter embryonic stem cell lin

91 At no time is Brachyury expressed in the stomochord, the putative homo

92 the animal, separated from the anterior oral brachyury-expressing region by a dorsal domain of ectode

93 e UTX KO embryos show severe defects in both Brachyury expression and embryonic development of mesode

94 Brachyury expression cannot be detected again until meta

95 uired for Wnt/beta-catenin signaling-induced Brachyury expression in ES cells.

96 ychodera and, by comparison with patterns of Brachyury expression in the indirect development of echi

97 Brachyury expression in the vegetal plate is confined to

98 age of human lung tumor tissues positive for Brachyury expression increased with the stage of the tum

99 at UTX controls mesoderm differentiation and Brachyury expression independent of H3K27 demethylase ac

100 , UTX regulates mesoderm differentiation and Brachyury expression independent of its enzymatic activi

101 Brachyury expression is not detected during the 5 months

102 Brachyury expression occurs in two distinct phases.

103 Brachyury expression patterns for Strongylocentrotus pur

104 nts of the proximal epiblast do not restrict Brachyury expression to the posterior epiblast.

105 cell colonies in that they typically lacked Brachyury expression, consistent with their post-mesoder

106 vel genetic interaction in which Mix induces Brachyury expression, standing in contrast to the relati

107 nstituted ES cells to mesoderm, by measuring brachyury expression, to hemangioblasts, by measuring bl

108 nic cancer cell lines with various levels of brachyury expression, we demonstrate that high levels of

109 in portions of the endoderm coincident with brachyury expression.

110 n of the 11-bp NREs in the promoter elevated Brachyury expression.

111 bx6 is directly or indirectly dependent upon Brachyury expression.

112 ompensates for the loss of UTX in regulating Brachyury expression.

113 We propose that caudal/Cdx, brachyenteron/Brachyury, fork head/HNF-3, and wingless/Wnt constitute

114 lation defined by the coexpression of either Brachyury, Foxa2 and c-Kit, or c-Kit and Cxcr4.

115 gene-regulatory feedback loop consisting of Brachyury, Foxa2, and Sox17 directs proper stem-cell lin

116 how that sudden loss of the mesodermal gene (Brachyury) from CNH and the mesoderm progenitor domain c

117 with message sequence from embryos in which Brachyury function had been "knocked-out" by injection o

118 in sea urchins, and with known or suggested Brachyury function in other species.

119 in gastrulation induced by interfering with Brachyury function in sea urchins, and with known or sug

120 ial candidate for complementing or extending Brachyury function in the anterior axis (formation of th

121 We also show that Brachyury functions primarily as a transcriptional activ

122 -8/18, carbonic anhydrase-12, and NC markers brachyury, galectin-3 and CD24 in cells of the NP irresp

123 iptomic data, immunolocalization of EOMES, T brachyury, GDF15 and active beta-catenin revealed differ

124 The Ciona Brachyury gene (Ci-Bra) is regulated, in part, by a 434-

125 hancer from the promoter region of the Ciona Brachyury gene (Ci-Bra), which is sufficient to direct a

126 the regulation of a notochord-specific Ciona Brachyury gene (Ci-Bra).

127 Ptychodera flava, and the expression of the Brachyury gene during this process.

128 d in this study with that of the orthologous Brachyury gene in an indirectly developing enteropneust

129 loss of Fgf8b disrupts the induction of the brachyury gene in the pregastrular embryo and, in additi

130 hese results and other data suggest that the brachyury gene transduces information about the state of

131 lopment, inducing the mesodermally expressed brachyury gene up to 10 cell diameters from a localised

132 However, the brachyury gene was present in the common ancestor of fun

133 at is the product of a premature stop in the brachyury gene.

134 and SpBra, the orthologue of the vertebrate Brachyury gene.

135 xpressing P19 cells resulted in decreased T (Brachyury) gene expression, a DNA-binding transcription

136 The duplicated region contains only the T (brachyury) gene, which is important in notochord develop

137 ilencing of the one-eyed-pinhead and no-tail/brachyury genes.

138 re defined a 'developmental clock' using the Brachyury-GFP signal onset timing.

139 Onset timing of Brachyury-GFP was highly variable across EBs, while the

140 strated that FGF-2 induced the expression of brachyury, goosecoid, and myo-D in regions of treated ex

141 s enhancer contains two sets of low-affinity Brachyury half-sites, which are bound in vitro by a GST/

142 A homologue of the T-box gene, Brachyury, has been isolated from hydra.

143 T-box genes related to brachyury have also been implicated in hindgut patternin

144 Our results indicated that resistance of brachyury-high tumor cells to immune-mediated attack was

145 gut development; within this region maps the Brachyury homolog T-related gene (Trg), DNA of which res

146 yses have shown that the genes no tail (ntl, Brachyury homolog), floating head (flh, a Not homeobox g

147 ce between unicellular holozoan and metazoan Brachyury homologs, suggesting that the specificity of B

148 escued by coinjection of the T-box gene ntl (Brachyury homologue), which is typically required for th

149 A comparison of the function of the Brachyury homologues suggests an evolutionary conservati

150 Lysine 149 of Xbra is conserved in all Brachyury homologues, while the corresponding amino acid

151 ays 7.5 and 8.5 expressed both HNF-3beta and Brachyury in a pattern similar to those of pre- and earl

152 represses Brachyury in Xenopus, it activates Brachyury in axolotl.

153 k and allowing us to compare the function of Brachyury in different species.

154 promoter microarrays to identify targets of Brachyury in embryoid bodies formed from differentiating

155 Overexpression of Brachyury in human carcinoma cells induced changes chara

156 expression of the T-box transcription factor brachyury in human carcinomas drives the phenomenon of e

157 Our results point to an ancient role for brachyury in morphogenesis, cell polarity and the patter

158 phenotype, demonstrating an ancient role for Brachyury in patterning all but the most anterior somite

159 Tbx6 expression thus overlaps that of Brachyury in the primitive streak and tail bud, although

160 The selective expression of Brachyury in tumor cells and its role in EMT and cancer

161 T(c) mouse model supports a crucial role of Brachyury in up-regulating multiple key hematopoietic an

162 this problem in our analysis of the role of Brachyury in Xenopus development, we have, like Kolm and

163 While Mix represses Brachyury in Xenopus, it activates Brachyury in axolotl.

164 unction of no tail (ntl, homologous to mouse brachyury) in DFCs without affecting its expression in o

165 We also showed PGC induction by Brachyury, in the presence of BMP4.

166 on of the key notochord transcription factor Brachyury, indicating that Brachyury is not a notochord

167 C genes are likely to be indirect targets of Brachyury-induced signaling from the surrounding endoder

168 we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal

169 nter in which the Notch and Wnt pathways and brachyury interact.

170 Brachyury is a member of the T-box gene family and is re

171 Brachyury is a sequence-specific transcriptional activat

172 Brachyury is a transcription activator, and its ability

173 Brachyury is a transcription factor that functions in ga

174 a overexpression of the transcription factor Brachyury is associated with enhanced secretion of multi

175 Since Brachyury is considered to have a major role in mesoderm

176 The T box transcription factor Brachyury is essential for the formation of the posterio

177 the primitive streak and tail bud, although Brachyury is expressed earlier in the primitive streak.

178 In ascidians, such as Ciona intestinalis, Brachyury is expressed exclusively in the notochord and

179 In vertebrates, Brachyury is expressed throughout the presumptive mesode

180 n embryos dissected between 5.5 and 6.5 dpc, Brachyury is first expressed in the distal extra-embryon

181 nscription factor Brachyury, indicating that Brachyury is not a notochord master regulator gene as st

182 the ascidian Ciona, in which the single-copy Brachyury is notochord-specific and CRMs are easily iden

183 Since Xenopus brachyury is proposed to regulate fgf expression, and FG

184 It is known that the transcription factor Brachyury is required for notochord formation in all cho

185 Here we show that Brachyury is specifically down-regulated in Wnt3a mutant

186 Brachyury is the founder member of the T-box family of t

187 Our data confirm that Brachyury is the most ancient member of the T-box family

188 mpensation and the recent demonstration that Brachyury is the prototype for an evolutionarily conserv

189 In the embryo, Brachyury is transcribed during gastrulation in the futu

190 e associated with dorsal mesoderm formation, brachyury, is expressed normally in alpha6 integrin-pert

191 c differentiation-related factors, including Brachyury, KDR, SCL, GATA2, and PU.1.

192 - EBs, associated with delayed expression of Brachyury, Klf1, and Gata1.

193 movements during gastrulation [no tail (ntl)/brachyury, knypek (kny) and pipetail (ppt)/wnt5] interac

194 rd alters an amino acid within the conserved brachyury-like domain.

195 he green fluorescent protein targeted to the brachyury locus demonstrates that the haemangioblast is

196 (ntl), the zebrafish homologue of the mouse Brachyury locus, display severe defects in midline and m

197 uorescent protein (GFP) cDNA targeted to the brachyury locus, we demonstrate that endoderm develops f

198 the foxa2 locus in addition to GFP from the brachyury locus.

199 e in EMT and cancer progression suggest that Brachyury may be an attractive target for antitumor ther

200 esults thus chart a comprehensive map of the Brachyury-mediated gene-regulatory network and how it in

201 v/Xlefty)-mediated functional antagonism and Brachyury-mediated transcriptional suppression.

202 Both approaches induced BRACHYURY(+) mesoderm of distinct PS-like identities, wh

203 T mutant Brachyury mice die in midgestation with severe defects i

204 Analysis of the spatial distribution of brachyury(+) midline cells shows that the Cfl1 mutant mi

205 ur results suggest that Wnt3a, signaling via Brachyury, modulates a balance between mesodermal and ne

206 Brachyury mRNA expression in the primitive streak of RIa

207 Axin2, Fgf8 and Wnt3a, is down regulated in Brachyury mutant embryos and we demonstrate that they ar

208 Brachyury mutant mice, which lack T protein, die in uter

209 as the spadetail mutant of zebrafish and the Brachyury mutant of the mouse, which both similarly exhi

210 fish tbx16/spadetail, nieuwkoid/bozozok, and Brachyury/no tail genes with dsRNA from the bacterial la

211 Our results reveal that neither Brachyury nor Wnt3 forms a ring of expression in the pro

212 Examination of the expression of brachyury, not, goosecoid, and papc indicated that conve

213 s targeting the zebrafish golden and no tail/Brachyury (ntl) genes and developed a budding yeast-base

214 FGF signaling represses the NMP markers brachyury (ntla) and sox2 through regulation of tbx16 an

215 rate functional conservation of a homolog of Brachyury of the protist Capsaspora owczarzaki in Xenopu

216 the T-box-containing transcription factors, Brachyury or Tbx6, also lack paraxial mesoderm.

217 The Brachyury, or T, gene is required for notochord developm

218 We have identified a second zebrafish Brachyury ortholog (Bra), and show that a combined loss

219 ranscription factors spadetail (spt) and the brachyury ortholog no tail (ntl) are together essential

220 mbryo, represses expression of the zebrafish brachyury ortholog no tail (ntl), causing a failure to s

221 es the expression of an ectopic patch of the brachyury ortholog no tail and leads to the formation of

222 studies of mouse Brachyury and the zebrafish Brachyury ortholog Ntl indicated that Brachyury plays a

223 The chick Brachyury orthologue and two related chick T-box genes t

224 of the mesenchymal and invasive features of Brachyury-overexpressing tumor cells and show that IL-8

225 Brachyury overexpression also repressed E-cadherin trans

226 ed the importance of HS for the induction of Brachyury(+) pan-mesoderm as well as normal gene express

227 xtinguished in mutant embryos as soon as the Brachyury phenotype becomes evident at 8.5 days postcoit

228 rafish Brachyury ortholog Ntl indicated that Brachyury plays a more significant role in higher verteb

229 p is a direct target gene of Ci-Bra and that Brachyury plays an immediate role in the cellular morpho

230 we demonstrate that endoderm develops from a brachyury(+) population that also displays mesoderm pote

231 in supporting hematopoiesis after specifying brachyury-positive mesoderm.

232 To explore ancestral roles of brachyury prior to the evolution of definitive mesoderm,

233 UTX and UTY bind directly to Brachyury promoter and are required for Wnt/beta-catenin

234 Jmjd3 reduces H3K27me3 marks at the Brachyury promoter and facilitates the recruitment of be

235 We further show that ntl and Brachyury promoter regions contain functional kappa B si

236 notably the muscle specifier Macho-1 and 50 Brachyury-regulated notochord genes, as well as several

237 ta significantly change the understanding of Brachyury regulation in Xenopus, implying the existence

238 osterior development, functioning in the FGF-brachyury regulatory loop.

239 hat the zebrafish tbx6 gene, a member of the Brachyury-related T-box family of genes, is exclusively

240 ntage of the system to provide evidence that Brachyury represses neural differentiation and that sign

241 Conversely, inhibition of Brachyury resulted in downregulation of mesenchymal mark

242 the binding preferences of the C. owczarzaki Brachyury results in a similar motif to that of metazoan

243 homozygous mutants, indicating that loss of brachyury results in stochastic fate transformation.

244 transcription activator of both Myc-Max and Brachyury site-containing reporters in a Max-dependent m

245 vity and expression of the mesodermal marker brachyury, suggesting that ERK1 can compensate for ERK2

246 p1, Ncdn and Nrp-1), transcriptional factor (Brachyury T), and cell surface receptors (CD24, CD90, CD

247 ebrate 'mesodermal' genes, such as nodal and brachyury T, are likely to ancestrally have been involve

248 Bmp-4), and the transcription factors of the Brachyury T-Box family (Tbx2-Tbx5) and Lung Kruppel-like

249 afish spadetail (spt)/VegT and no tail (ntl)/Brachyury T-box genes are semi-redundantly and cell-auto

250 be detected during the transitory phase from Brachyury (T) (+) mesendoderm toward a CXCR4 (+) DE stat

251 Mesodermal markers mox-1, Notch-1, Brachyury (T) and Sonic hedgehog (Shh) were expressed in

252 notably, upregulation of mesendoderm genes, Brachyury (T) and Sox17.

253 onal analysis has demonstrated that Fgf8 and Brachyury (T) are required for normal mesoderm and left-

254 Because brachyury (T) denotes mesoderm specification, a mouse ES

255 ouse conceptuses homozygous for mutations in brachyury (T) exhibit a short, misshapen allantois that

256 In addition, CD protein (CD24 and CD90) and Brachyury (T) expression in immature disc cells were als

257 Abrogation of Brachyury (T) expression within the chordamesoderm of ho

258 The gene (TBX5) is a member of the Brachyury (T) family corresponding to the mouse Tbx5 gen

259 The mouse Brachyury (T) gene plays critical roles in the genesis o

260 putative transcription factors including the Brachyury (T) gene product.

261 ions of the notochordal transcription factor brachyury (T) in up to 27% of cases.

262 The T-box transcription factor Brachyury (T) is essential for formation of the posterio

263 Brachyury (T) is the founding member of this T-box trans

264 ications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations

265 econd (T2) gene is 15 kb away from classical Brachyury (T).

266 The transcription factor brachyury (T, BRA) is one of the first markers of gastru

267 d and the onset of gastrulation, marked by T/Brachyury (T/Bra) at the posterior of the embryo.

268 of mesodermal markers prior to expression of Brachyury/T and acceleration of the mesodermal developme

269 This leads to a graded repression of the Brachyury/T transcription factor, reducing mesoderm ingr

270 s essential for its biological function, but Brachyury target genes have proved difficult to identify

271 factor binding in the regulatory regions of Brachyury target genes in rodents.

272 leotide to generate a differential probe for brachyury target genes.

273 uence 5'-TCACACCT-3' in the vicinity of most Brachyury target genes.

274 mbryos and we demonstrate that they are also Brachyury targets in the human.

275 gets of Brachyury, but little is known about Brachyury targets in the mouse.

276 The mouse Brachyury the Second (T2) gene is 15 kb away from classi

277 ryo and consequently tail length: Brachyury, Brachyury the second, and the t-complex tail interaction

278 We previously noted that the chick T gene (Brachyury), the prototypical T-box transcription factor,

279 brachyury, the founding member of the T-box gene family,

280 The ability of Brachyury to activate transcription is essential for its

281 Furthermore, we found Brachyury to be overexpressed in various human tumor tis

282 network that directly links the function of Brachyury to diverse developmental pathways and cellular

283 analyses of the expression of HNF-3beta and Brachyury, two molecular markers for gastrulation, showe

284 The interaction between Mix and Brachyury, two transcription factors involved in the est

285 of FGF/Erk signalling mediates this loss of Brachyury upstream of Wnt signalling, while high-level F

286 oup, they reveal the evolutionary history of Brachyury utilization in deuterostomes.

287 ue of the T-box family transcription factor, Brachyury, was cloned through a candidate gene approach.

288 regulation of the T-box transcription factor brachyury We find in zebrafish that FGF is continuously

289 nd the amount of nascent mesoderm expressing Brachyury were both severely reduced.

290 ucts has come mainly from the prototypical T/Brachyury, which is a transcription activator.

291 e find that the genes caudal, orthopedia and brachyury-which are expressed in various bilaterian hind

292 age of immature NP cells expressing CD24 and Brachyury, while higher percentage of immature AF cells

293 ing the molecular phenotype of C. owczarzaki Brachyury with that of homologs of early branching metaz

294 d interaction of the family members Tbx3 and Brachyury with the CRM1 exporter, suggesting general sig

295 of the early vertebrate embryo depends on a Brachyury/Wnt autoregulatory loop within the posterior m

296 the polarized expression domains of Xenopus brachyury (Xbra) and Xenopus nodal-related factor 2 (Xnr

297 pression of Sox17 in vegetal blastomeres and Brachyury (Xbra) in marginal blastomeres.

298 expression of the general mesodermal marker Brachyury (Xbra) requires a zygotic, ligand-dependent Wn

299 at confers mesodermal identity in Xenopus is Brachyury (Xbra), which is required for normal gastrulat

300 The Xenopus homologue of Brachyury, Xbra, is expressed in the presumptive mesoder

301 Transcripts encoding brachyury, Xwnt8 and goosecoid colocalize with Xombi tra