ライフサイエンスコーパス: brain

1 n as a regulator of insulin signaling in the brain.

2 y platform for localized gene therapy in the brain.

3 re applied to noradrenaline receptors in rat brain.

4 t rather confined to specific regions of the brain.

5 or source of nociceptive transmission to the brain.

6 could cause lasting damage to the developing brain.

7 important for information processing in the brain.

8 represented in domain-specific areas of the brain.

9 orary control of lentiviral infection in the brain.

10 le silver measured in the olfactory bulb and brain.

11 ing other structures, such as neurons in the brain.

12 ed by expression of type I interferon in the brain.

13 oper alignment of neural maps throughout the brain.

14 odal information is represented in the human brain.

15 RTN1 and RTN3 is tightly regulated in mouse brains.

16 cohort were mainly gastrointestinal (31.8%), brain (22.7%), or lung (20.7%).

17 genes except for Tph1 were expressed in the brain above the array median, and remained significantly

18 taneous BOLD signal variability in the human brain across the lifespan.

19 Synaptic transmission controls brain activity and behaviors, including food intake.

20 at kisspeptin administration enhanced limbic brain activity specifically in response to sexual and co

21 We have developed mathematic models of brain activity that allow for accurate prediction of reg

22 rd lists to investigate how left-hemispheric brain activity varies during the formation of phrase str

23 The pathological brain activity was recorded intra-operatively via implan

24 tive or passive sounds while measuring their brain activity with fMRI.

25 at of unpredictable shocks while we recorded brain activity with fMRI.

26 We measured brain activity with functional magnetic resonance imagin

27 dual behaviors across tasks with patterns of brain activity.

28 lay important roles in neurodegeneration and brain aging.

29 otential neurobiological basis of structural brain alterations in the disorder, highlighting impedime

30 riability related to specific regions of the brain and add to a growing literature demonstrating the

31 ly argued that the study of the link between brain and behavior is impossible without a guiding visio

32 nclude a cardiovasculopathy that affects the brain and can be detected and characterised by WMH.

33 ttranslational modifications of FOXP2 in the brain and disorders have been explored.

34 hout equal efficiency in all tissues (aorta, brain and kidney), resulted in rapid lethality marked by

35 ired drainage of interstitial fluid from the brain and may reflect underlying cerebral small vessel d

36 h assess odor processing pathways within the brain and provide a limited understanding of primary odo

37 The large brain and small postcanine teeth of modern humans are am

38 locus coeruleus (LC) projects throughout the brain and spinal cord and is the major source of central

39 CL were almost completely absent in both the brain and spinal cord when intracranial and intrathecal

40 spinal (43.4pg/ml, IQR = 25.2-65.3) or both brain and spinal gadolinium-enhancing lesions (62.5pg/ml

41 ctures and neuronal responses within the bee brain and subsequently compared their ability to general

42 udy, we report that CGRP can act in both the brain and the periphery of the mouse to cause migraine-l

43 age to the developing vascular system of the brain, and altered cellular positioning.

44 e in both WT and KO mouse visceral yolk sac, brain, and spinal column.

45 Women carrying a fetus suspected of having a brain anomaly on ultrasound had iuMRI done within 14 day

46 works representing various commonly observed brain architectures.

47 Recent work suggests that the amygdala, a brain area important for processing emotion, may be part

48 ral blood flow and metabolic activity in key brain areas compared with control subjects.

49 idely distributed manner throughout multiple brain areas, but that the striatum may have a privileged

50 associated with low levels of SIV RNA in the brain as shown by in situ hybridization, and generally w

51 eu), to severe neurodevelopmental delay with brain atrophy (p.Ser94Arg) and extend the clinical outco

52 tive decline, and drives amyloid-independent brain atrophy during the earliest stage of disease.

53 o age, sex and hypertension independent from brain atrophy.

54 nostic value for clinical HD progression and brain atrophy.

55 ment were independent of global and regional brain atrophy.

56 ging and Alzheimer Disease Center and Oregon Brain Bank.

57 that [(11)C]-(R)-3 readily crosses the blood-brain barrier (BBB) in rodents and selectively binds to

58 Culture-based blood-brain barrier (BBB) models are crucial tools to enable r

59 rovides a powerful means to bypass the blood-brain barrier and drive widespread distribution of thera

60 Blood-brain barrier disruption (BBB) and release of toxic bloo

61 an all-human, in vitro, 3-dimensional, blood-brain barrier model exemplifies tight-junction integrity

62 The blood brain barrier separates the circulating blood from the e

63 s with optimal penetration through the blood-brain barrier should be considered even for patients wit

64 notion of neuroscience when it comes to the brain-behavior relationship: behavioral work provides un

65 entral nervous system with a very favourable brain/blood ratio.

66 ified multiple face-selective regions in the brain, but the functional connections between these regi

67 t correlation between residential radon with brain cancer mortality for males and females and the int

68 an association between residential radon and brain cancer mortality.

69 Our results establish brain capillaries as an active sensory web that converts

70 y-state level, with an impact on surrounding brain cells, remains unknown.

71 SIGNIFICANCE STATEMENT Effective disposal of brain cellular waste products via CSF has been demonstra

72 a negative impact of SVD-related morphologic brain changes on gait speed in addition to age, sex and

73 ual subpopulations of neurons and ultimately brain circuits is largely unknown.

74 achieve chronic multimodal interrogation of brain circuits with high fidelity.

75 We quantify neuropeptide abundance in brains collected from three behavioural states: solitary

76 peripheral immune pathways in microbiota-gut-brain communication during health and neurological disea

77 ms of cognitive decline related to immune-to-brain communication, such as Alzheimer's and Parkinson's

78 ent Components Analysis to obtain functional brain components from 98 healthy participants aged 23-87

79 Brain-computer interface-assisted motor imagery (MI-BCI)

80 red stimulation performed with Bidirectional Brain-Computer-Interfaces (BBCI) can artificially streng

81 Although changes in resting-state brain connectivity are a transdiagnostic key finding in

82 t should be a generalizable model that takes brain connectivity data as input and generates predictio

83 gagement, and highlight selective changes in brain connectivity supporting increases in task complexi

84 ion imaging is central to the study of human brain connectivity.

85 The primate brain contains a hierarchy of visual areas, dubbed the v

86 nd release of toxic blood molecules into the brain contributes to neuronal injury during stroke and o

87 n attachment in providing a template for two-brain coordination.

88 bystander CPR was associated with a risk of brain damage or nursing home admission that was signific

89 d a lower risk of the composite end point of brain damage, nursing home admission, or death (hazard r

90 s of cortical neuropil, plausibly even whole-brain datasets.

91 lating CD4+ cells in the HIV-negative (HIV-) brain-dead donor (BDD) is not known.

92 , named Nogo-A-Delta20, binds to heparin and brain-derived heparan sulfate glycosaminoglycans (GAGs)

93 DLG4 is thus apparently involved in brain development and impacts inter-individual susceptib

94 n-mediated generation of L1-80 contribute to brain development at early developmental stages.

95 that REM sleep has multifaceted functions in brain development, learning and memory consolidation by

96 how loss of maternal UBE3A function derails brain development, we analyzed brain structure in a mate

97 s and diverse types, and thus dictate proper brain development.

98 Structural brain differences have been associated with BD, but resu

99 Why does the brain discard so much visual information?

100 Serious brain disorders, such as the Alzheimer's Disease (AD), a

101 instead predicted by the stability of their brain dynamics.

102 predominately PVC ablations) experienced new brain emboli after the procedure.

103 Primary SJL mouse brain endothelial cells (a target of MAV-1 in vivo) infe

104 The multiparous brain exhibited features of immune suppression, with dam

105 ements of oxygen with high resolution in the brain extracellular space.

106 Understanding how the brain extracts depth from two different retinal images r

107 Finally, brain extracts of SSTCre:gamma2(f/f) mice showed decreas

108 rior fundus (AF) face patch, combining whole-brain fMRI with longitudinal single-unit recordings in a

109 deceased football players who donated their brains for research, a high proportion had neuropatholog

110 laropiprant limits bleeding and rescues the brain from ICH.

111 Brains from adult and newborn sheep (injected with BrdU

112 factors for Alzheimer's disease (AD) affect brain function and cognition in healthy adult samples ma

113 g cytokine overactivity that act directly on brain function and/or treatment in early-stage psychosis

114 etal resting-state functional MRI to measure brain function in 32 human fetuses in utero and found th

115 Sleep is essential for proper brain function in mammals and insects.

116 and hemodynamic responses, is a fundamental brain function that underlies hemodynamic-based function

117 ion in spike timing actually plays a role in brain function.

118 volume in other brain pathologies and normal brain function.

119 se homeostatic plasticity to maintain normal brain functions and to prevent abnormal activity.

120 including these cell types for investigating brain functions.

121 4 regulate neuronal function by catabolizing brain gangliosides.

122 he transcriptomes using Gene Ontology, adult-brain gene lists generated by Translating Ribosome Affin

123 offers a noninvasive tool for investigating brain glycosylation, which could be developed in to brai

124 miRNA profiling in the human brain has revealed miR-132 as one of the most severely d

125 The brain has the highest mitochondrial energy demand of any

126 with the limits to miniaturization in insect brains have until now relied on information based on dat

127 tary tests, including polysomnography (PSG), brain imaging and genetic analysis, were used.

128 that underlies hemodynamic-based functional brain imaging techniques.

129 However, how the brain implements this important decision heuristic and w

130 repeated reactivation of latent HSV1 in the brain in AD pathogenesis are also discussed.

131 of radioligand binding to neuroreceptors in brain in vivo, here applied to noradrenaline receptors i

132 the region-specific function of FOXP2 in the brain, in particular the cerebellum, nor the effects of

133 y of myelin deficit lesions in rhesus monkey brain induced by experimental autoimmune encephalomyelit

134 Moreover, Malat1 KO mice presented larger brain infarct size, worsened neurological scores, and re

135 Predictive coding suggests that the brain infers the causes of its sensations by combining s

136 Traumatic brain injury (TBI) causes extensive neural damage, often

137 rs including Alzheimer disease and traumatic brain injury (TBI).

138 on mediated by microglia plays a key role in brain injury associated with preterm birth, but little i

139 t of secondary injury after severe traumatic brain injury based on brain tissue oxygenation and intra

140 This suggests that the link between AF and brain injury extends beyond thromboembolic complications

141 dysfunction among moderate-severe traumatic brain injury patients.

142 what opposite, roles in motor recovery after brain injury.SIGNIFICANCE STATEMENT The dorsal and ventr

143 t multiple system atrophy is associated with brain insulin resistance and showed increased expression

144 oblastoma, inhibiting Wnt5a activity blocked brain invasion and increased host survival.

145 ral discounting is related to regions of the brain involved in reward processing and interoception.

146 t gelatin-based molds in which a whole mouse brain is embedded, flash frozen, and cryosectioned in pr

147 These findings were surprising because the brain is isolated from environmental microorganisms.

148 interaction analyses are implemented in the brain is unknown.

149 a detailed analysis of p11 expression in the brain is warranted.

150 The brain lacks lymph vessels and must rely on other mechani

151 order of these subpopulations to the injured brain largely remains unknown.

152 eous deconvolution of O(105) traces of whole-brain larval zebrafish imaging data on a laptop.

153 hologies in a selected manner throughout the brain, leading to intellectual deficits and sensory dysf

154 s, allowing us to systematically dissect how brains learn.

155 12, respectively) than those without frontal brain lesions (1/11, P's < 0.05).

156 ividuals are prone to seizures and have high brain levels of the inflammatory cytokine IL-1beta.

157 rpus callosum (AgCC), one of the most common brain malformations to identify differences in the effec

158 e microcephaly and a wide spectrum of severe brain malformations.

159 lycosylation, which could be developed in to brain mapping applications, but also serves as a potenti

160 ignals during task performance is related to brain maturation in old age as well as individual differ

161 tifying normative trajectories of functional brain maturation.SIGNIFICANCE STATEMENT Although brain s

162 of cannabis use whereby global and regional brain metabolism are altered in those with prolonged can

163 Reference databases of pediatric brain metabolism are uncommon, because local brain metab

164 brain metabolism are uncommon, because local brain metabolism evolves significantly with age througho

165 or accurate prediction of regional pediatric brain metabolism.

166 examined specific eligibility criteria (ie, brain metastases, minimum age, HIV infection, and organ

167 of the 2 patients, subsequent resection of a brain metastasis proved HER2-positive disease, confirmin

168 intracranial control following resection of brain metastasis.

169 The lifespan of brain microglia, however, remains uncertain, and reflect

170 AV9-mediated repletion of the protein averts brain microvasculature defects and prevents disease, whe

171 e knockdown of Myt1l in the developing mouse brain mimicked a Notch gain-of-function phenotype, sugge

172 information capacity measured through whole brain models is a theory-driven measure of processing ca

173 hich correlated with the global reduction in brain modularity.

174 Brain morphometric data were employed to create multivar

175 The brain needs to predict how the body reacts to motor comm

176 a dynamic model implemented on an anatomical brain network (connectome), we investigate the similarit

177 ing a connectomics approach to understanding brain network architecture, employing advanced magnetic

178 Classification analysis of their brain network identified each of these misdiagnosed pati

179 rtex and superior parietal lobule influences brain networks associated with tactually-extracted motio

180 ply the analytical methods to the anatomical brain networks of human, macaque, and mouse, successfull

181 ngled PC subsets that contribute to separate brain networks remains unclear.

182 pected perfusion decreases in regions of the brain normally associated with the 'default mode' or 'ta

183 ents the highest neurogenic potential in the brain of the adult individual.

184 p of the catecholaminergic structures in the brain of two representative species of lungfishes, an Af

185 of key enzymes of the kynurenine pathway in brains of newborn and adult infected rats and cultured a

186 a-syn frequently appears to propagate in the brains of PD patients following a stereotypic pattern co

187 ated in neuroinflammation, MMP2 and MMP9, in brains of susceptible mice.

188 the role of steroid hormone signaling in the brain on distinct features of birdsong using adult male

189 Patients with either brain or spinal (43.4pg/ml, IQR = 25.2-65.3) or both bra

190 sts that flicker may also entrain endogenous brain oscillations, thereby modulating cognitive process

191 e widespread distribution of therapeutics in brain parenchyma away from the point of local administra

192 ntrations, and dynamics cell volume in other brain pathologies and normal brain function.

193 BA, A53T-SNCA mouse model) were exposed to a brain-penetrant GCS inhibitor, GZ667161.

194 e crucial tools to enable rapid screening of brain-penetrating drugs.

195 MR imaging measures of brain perfusion and metabolism were compared among eight

196 neuronal hypometabolism, predates changes in brain perfusion, exacerbates and works synergistically w

197 unteers-3 HABs, 3 MABs, and 2 LABs-underwent brain PET imaging.

198 ell signaling that is expressed as different brain phosphoprotein profiles.

199 The study of brain plasticity has tended to focus on the synapse, whe

200 ociation between 18 kDa translocator protein brain positron emission tomography signal, which arises

201 elated events in the periphery can influence brain processes is essential for the development of ther

202 urrent understanding of healthy and adaptive brain processing.

203 Whole brain radiotherapy (WBRT) is the standard of care to imp

204 Time-activity curves, slope, and tumor-to-brain ratios of (18)F-FET uptake (18-61 min after inject

205 to this problem is the mechanism by which a brain region adjusts its activity according to the influ

206 d sequentially [10-14], making this an ideal brain region for investigating the circuit-level impact

207 Our findings show that, in the striatum, a brain region implicated with movement execution, EAAC1 l

208 Thus, in a brain region not normally associated with sex difference

209 niche position and relocate to a non-native brain region that is rich in neurosecretory neurons, inc

210 TSPO VT was significantly elevated in these brain regions (mean, 32%; range, 31%-36% except anterior

211 tolerated, able to chelate iron from various brain regions and improve PD symptomology.

212 d reduced functional connectivity in frontal brain regions and increased functional connectivity in p

213 cal oscillations of a network of a number of brain regions are implicated in leading to the disorder.

214 lesion network mapping was used to identify brain regions functionally connected to the lesion locat

215 th the structural changes of specific social brain regions in late adolescence.

216 based on gene expression profiles delineated brain regions into structurally tiered spatial groups an

217 itory sensory, but also frontal and parietal brain regions involved in controlling auditory attention

218 creased functional connectivity in posterior brain regions of postweaning social isolation rats.

219 ve reductions of VMHC associated with ALS in brain regions of the precentral and postcentral gyrus, t

220 ot enough studies for meta-analysis in other brain regions studied (hippocampus, ventral pallidum and

221 ange cross-frequency coupling across distant brain regions subserves working memory.

222 We show how brain regions tend to coordinate by forming a highly hie

223 scans, in the parieto-temporal and precuneus brain regions was associated with greater 18F-AV-1451 PE

224 nd serotonin transporter binding in multiple brain regions were compared by ANCOVA, adjusted for age.

225 unterparts of otherwise unilaterally engaged brain regions, a strategy that seems to be at odds with

226 Since depression affects multiple brain regions, and the role of p11 has only been determi

227 ys (ELISA) or theoretically calculated in 12 brain regions, including neocortical, limbic and subcort

228 so receives input from other retinorecipient brain regions, primarily via the geniculohypothalamic tr

229 functional specialization of the reorganized brain regions.

230 gen signaling differ between and even within brain regions.

231 cal signaling to direct blood flow to active brain regions.

232 ic Tau, followed by its spreading to distant brain regions.

233 ese analyses to prenatal ages and additional brain regions.

234 filing of chemoconvulsant action in multiple brain regions.

235 al binding parameter Kb varied highly across brain regions.

236 uronal morphology is maintained in the adult brain remains poorly understood.

237 Accordingly, the pattern of brain reorganization may be more extensive [3].

238 How does the brain reorganize when one of these channels is absent?

239 evealing how social interactions can recruit brain reward systems to drive changes in affiliative beh

240 ating cognitive processes supported by those brain rhythms.

241 is study shows that focal lesions affect the brain's ability to represent stimuli and task states, an

242 e found to show connectivity deficits of the brain's central rich club (RC) system relative to both c

243 c forgetting, the latter term describing the brain's chronic signaling systems that function to slowl

244 and provide the initial sensory input to the brain's olfactory bulb.

245 Deeper exploration of the brain's vast synaptic networks will require new tools fo

246 xtensive sectioning and reconstruction for a brain sample.

247 remained unaltered in adult WT and KO mouse brain, SC, and kidneys.

248 al sites analysed structural T1-weighted MRI brain scans with harmonised protocols of individuals wit

249 have motivated theoretical models of how the brain selects actions, regulates movement initiation and

250 relationship between motor commands that our brain sends to our arm muscles and the resulting motion

251 n maturation.SIGNIFICANCE STATEMENT Although brain signal variability has traditionally been consider

252 recent work demonstrates that variability in brain signals during task performance is related to brai

253 tions in sex, sex chromosome complement, and brain size.SIGNIFICANCE STATEMENT Cerebellar systems are

254 Neurons promote the growth of cancers of the brain, skin, prostate, pancreas, and stomach.

255 sent study, we established an in vitro mouse brain slice preparation that retains connectivity across

256 consumed nutrient can paradoxically sustain brain starvation signals, and identify a biological fact

257 of focal lesions or the application of deep brain stimulation (DBS) within circuits that modulate mo

258 alogram and local field potentials from deep brain stimulation electrodes in 9 Parkinson's disease pa

259 ilepticus, suggesting a pivotal role of deep brain stimulation in the treatment response.

260 cross different clinical indications of deep brain stimulation surgery.

261 ents while undergoing implantation of a deep brain stimulator.

262 ction derails brain development, we analyzed brain structure in a maternal Ube3a knock-out mouse mode

263 urons were recorded simultaneously from five brain structures in an awake mouse.

264 Transcriptomic analysis of sonicated brain supported the proteomic findings and indicated tha

265 Our findings link brain-to-brain synchrony to the degree of social connectedness am

266 Brain systems supporting face and voice processing both

267 te reveal for the first time a collection of brain targets of Galphat-S-ir neurons, suggesting they m

268 te pathways from sensory detection to higher brain that influence innate behavior and are essential f

269 xhibit cortical plasticity in regions of the brain that were central to the emergence of speech funct

270 ders and custodians of the BBB in the normal brain, their impact on BBB integrity during ischemia rem

271 n the intraparietal sulcus of the developing brain, those effects could be explained by patterns of n

272 ect access to pathological and control human brain tissue based on an individual's genetic architectu

273 Our results show that brain tissue deformation induced by head impact loading

274 lpha-synucleinopathy model and in postmortem brain tissue from patients with alpha-synucleinopathy.

275 imaging methods that quantify biomarkers of brain tissue microstructure, integrating data from multi

276 after severe traumatic brain injury based on brain tissue oxygenation and intracranial pressure value

277 in lymphoblastoid cell lines and human fetal brain tissue.

278 s also found in many tissue types, including brain tissue.

279 fects the subventricular zone in human fetal brain tissues and that the tissue tropism broadens with

280 additionally to its local actions in the AD brain, TNF-alpha can also indirectly modulate amyloid pa

281 Our findings link brain-to-brain synchrony to the degree of social connect

282 inflammation, resulting in multiple forms of brain toxicities.

283 Analysis of brain transcriptomes during the transition reveals that

284 m and thus presents an essential obstacle to brain transport of therapeutics.

285 comes associated with exposure to repetitive brain trauma (RBT) continues to strengthen.

286 emains the most common and deadliest type of brain tumor and contains a population of self-renewing,

287 ing for patient age, gender and histological brain tumor diagnosis (beta = -0.253, p < 0.001).

288 signals.SIGNIFICANCE STATEMENT By comparing brain tumor patients to healthy children, we establish t

289 s and significantly prolongs the survival of brain tumor-bearing mice.

290 delivery of therapeutic nucleic acids within brain tumors and provide a promising new delivery platfo

291 Optic gliomas are brain tumors characterized by slow growth, progressive l

292 s can enhance the permeability of the BTB in brain tumors, as well as disrupting the BBB in the surro

293 Resting levels of O2 in the rodent brain varied between 6.6 +/- 0.7 muM in the dentate gyru

294 through the analysis and modelling of human brain voltage activity recorded simultaneously across mi

295 n pseudoreference VT or SUV, excepting whole-brain VT, which was higher in cLBP patients than control

296 ning occurred prior to Il1b detection in the brain, when systemic inflammation was minimal.

297 alternative splicing plays a pivotal role in brain, where it affects neuronal development, function,

298 ion in the vertebrate body, including in the brain, where it has a key role in membrane trafficking,

299 ing, and intergenic RNAs in the mature mouse brain with RNA-Seq and validation with independent metho

300 cross-talk are largely conserved in the NMR brain, with the exception of the unique presence of RFRP