ライフサイエンスコーパス: branch point

1 on every 75th carbon (74 methylenes between branch points).

2 be 10.9 +/- 1.2 kT (17.0 +/- 1.3 kT without branch points).

3 155 and promotes U2 snRNP recruitment to the branch point.

4 ANF has as an allosteric effect on a kinetic branch point.

5 ng occurs primarily at the predicted distant branch point.

6 ern after stable U2 snRNP association to the branch point.

7 pendent association of the U2 snRNP with the branch point.

8 ies consistent with random excursions of the branch point.

9 er 8 or 12 double-helical arms surrounding a branch point.

10 ut did not regrow when severed distal to the branch point.

11 s limited by the number of arms flanking the branch point.

12 3'-most branch site adenosine served as the branch point.

13 terically protected region downstream of the branch point.

14 Watson-Crick base pairing with the 5' ss and branch point.

15 , while the N-terminal region can serve as a branch-point.

16 rafficking of secretory cargo near dendritic branch points.

17 ff-synaptic locations in the axon and axonal branch points.

18 roximal dendritic arbor, preferentially near branch points.

19 cal DNA and whose vertices correspond to the branch points.

20 motor protein steers growing microtubules at branch points.

21 , but not exclusively localized at dendritic branch points.

22 but few cold spots, are located at dendritic branch points.

23 dextran) which also contain alpha-(1,3,6)Glc branch points.

24 g cells and in the correct identification of branch points.

25 p moving and localize stably to synapses and branch points.

26 hways and the factors affecting flux through branch points.

27 ted, and do not aggregate normally at axonal branch points.

28 identified both canonical and exon-skipping branch points.

29 e specificity for the formation of nonrandom branch-points.

30 0 and Q633 to establish a pivotal allosteric branching point.

31 repare a highly crowded 1,2,3-cis configured branching point.

32 differences were also found at the pyruvate branching point.

33 nic, as they possess inorganic atoms at each branching point.

34 axon, 70 mum after the most distal dendritic branching point.

35 ) and dimethylthexylsilyl ether (TDS) at key branching points.

36 rious patterns of alpha-d-Gal and beta-d-Gal branching points.

37 rotecting groups made it possible to install branching points.

38 network into two branches at randomly chosen branching points.

39 mpetitive and clarifies decisions at pathway branching points.

40 ding sites emerged at the major evolutionary branching points.

41 lyzed for their length, area and quantity of branching points.

42 ensities of vessel area, length, number, and branch point (A(v), L(v), N(v), and Br(v)).

43 positions-donor and acceptor splice sites, a branch point, a polypyrimidine tract and suitable splici

44 pressors function by simply interfering with branch point accessibility to general splicing factors.

45 designed an artificial C/D RNA to target the branch point adenosine of ACT1 pre-mRNA to block its spl

46 utations cluster in a pocket surrounding the branch point adenosine, suggesting a competitive mode of

47 r cell growth, suggesting that targeting the branch-point adenosine was truly 2'-O-methylation-specif

48 rick pairing with the 5' splice site and the branch-point adenosine.

49 p the interactions of the ssDNA tail and the branch point along the helicase and Zn-binding domains,

50 Control at this branch point also prevents accumulation of intermediates

51 that the highly conserved region between the branch point and 3'-splice site is primarily unstructure

52 ot interaction between a C-rich bulge at the branch point and a G-rich bulge in the main helix.

53 enzymes function at the N-glycan processing branch point and are major factors determining the net o

54 Knock-outs of regulators of this metabolic branch point and of its central enzyme, pyruvate kinase

55 res, including a more distal location of the branch point and presence of a pyrimidine immediately be

56 repeats use cryptic 3'SSs downstream of the branch point and provide both a mechanistic model consis

57 ne (Py) tracts typically present between the branch point and the 3' splice site by the large subunit

58 A UUUUCCCCCC motif situated between the branch point and the 3' splice site is crucial for inclu

59 pin itself showed enrichment at hyphal tips, branch points and anucleate regions.

60 ng analysis reveals that MAP7 is enriched at branch points and colocalizes with stable microtubules,

61 the vasculature is preferentially located at branch points and curves where blood flow is disturbed a

62 d number of capillary segments and capillary branch points and decreased complexity of the glomerular

63 in less organized microtubules at dendritic branch points and decreased dendritogensis.

64 FMRP in NL/MSO neurons often accumulates at branch points and enlarged distal tips, loci known to be

65 Crossing points are distinguished from branch points and excluded.

66 ex to both "prune" daughter filaments at the branch points and inhibit new actin assembly.

67 The vessels had few branch points and many vascular anastomotic connections

68 ined by increased ER complexity at dendritic branch points and near dendritic spines.

69 ue, Kv1.1, cause hyperexcitability near axon branch points and nerve terminals, thereby leading to un

70 xon are very diverse structures encompassing branch points and numerous presynaptic terminals with un

71 raction, vessel length and number, number of branch points and perfusion status of the newly formed v

72 some neurons collateralize, what determines branch points and projection foci, and how this impacts

73 glomerular capillary segments and capillary branch points and restored complexity of the capillary n

74 length of dendritic wiring to the number of branch points and synapses.

75 t microtubule growth is directed at dendrite branch points and that kinesin-2, APC, and EB1 are likel

76 , whereas disturbed flow with oscillation in branch points and the aortic root are athero-prone, in p

77 s were topologically more complex, with more branch points and tortuous dendritic paths.

78 multiple cortical columns, and to have >1000 branch points and total axon lengths up to 50 cm.

79 onsistent with this notion, Raw localizes to branch-points and promotes dendrite stabilization togeth

80 the more complex songs of Bengalese finches, branching points and bidirectional transitions in song s

81 ated 2 weeks after birth triggers fewer duct branching points and fewer terminal end buds (TEBs) and

82 starch with a high DS occurred both near the branching points and the non-reducing ends.

83 olic pathway motifs (e.g., linear chains and branching points) and also under the conditions of fast

84 Cys despite an ester linkage at the C-extein branch point, and (d) an absolute requirement for the WC

85 ts exhibit abnormal placement of the neurite branch point, and defective synaptogenesis, characterize

86 uch as fibril diameter distribution, length, branch points, and fibril aggregations.

87 We quantified network formation by number of branch points, and longitudinal and lateral growth of fi

88 nct Golgi compartments in soma and dendritic branch points, and the specific distribution of GM130 de

89 dal shape, showed reduced segment length and branching points, and reduced adhesion molecule and cons

90 ferential gene expression at major metabolic branch points appears to be responsible for controlling

91 that biochemical steps before the monolignol branch point are shared between phenylpropene and lignin

92 l processing and that the properties of axon branch points are adjusted to maintain faithful transmis

93 -seq) reveals that introns with nonconsensus branch points are particularly sensitive to H2A.Z loss.

94 Branching points are considered to be the risk points of

95 Branching points are detected on the vessel centerline i

96 tream enzymes, particularly those at pathway branch points, are expected to exhibit more frequent ada

97 cts, unconventionally positioned upstream of branch points, are unaffected by U2AF inactivation.

98 ts were calculated for fluxes around the key branch point at Phe and revealed that phenylacetaldehyde

99 thesis utilizes Michael addition to create a branch point at the end of a PEG chain combined with car

100 eaching their final length and the number of branch points attained maximum values at 60% of maximum

101 that growing microtubule plus ends entering branch points be actively directed toward the cell body.

102 formate, an intermediate that serves as the branch point between assimilation (formation of biomass)

103 A represents a novel mechanistic node at the branch point between commitment to either Treg or Th17 l

104 This reaction sits at the branch point between the de novo pathway and the salvage

105 cell-to-endothelium transmission and also at branch points between a capillary and its tertiary arter

106 flexible mechanism of flux diversion at the branch-point between the anthocyanin and proanthocyanidi

107 lace these unconventional lymphocytes at the branching point between antigen-presenting cells and nat

108 cient polar bear lies almost directly at the branching point between polar bears and brown bears, elu

109 However, the developmental branching points between these two large cell compartmen

110 es cerevisiae is initially recognized by the branch point-binding protein (BBP).

111 Duplex formation between the branch point-binding region (BBR) of U2 snRNA and the br

112 nuclear ribonucleoprotein (U2AF) facilitates branch point (BP) recognition and formation of lariat in

113 Sequences 5' from the branch point (BP) region strongly influence drug sensiti

114 er of green fluorescence protein-positive UB branch points (BP) and tips was monitored in each explan

115 tures having a nascent lagging strand at the branch point but no leading strand.

116 it is weakly decelerating costs that lead to branching points, but weakly accelerating and linear cos

117 that growing microtubules navigate dendrite branch points by turning the same way, toward the cell b

118 Diameter changes at branch points can be as large as 20-fold.

119 Mapping of the intron 4 branch point confirmed that branching occurs primarily a

120 ropionate group is the previously postulated branching point connecting proton transfer to the E-path

121 erestingly, mutating BDF2 5' splice site and branch point consensus sequences partially suppresses th

122 t that even subtle membrane readjustments at branch points could drastically alter the ability of syn

123 A branching point could be installed by using 9-fluorenylm

124 sors of splice-site mutations, and an intron branch-point crosslink, map to a large cavity formed by

125 IN is an essential adaptor downstream of the branch point defined by the panr2 mutation in NEMO.

126 medulla including: spine density, number of branch points, dendrite length, surface area and volume.

127 rine retinal vasculature, elevating vascular branch point density and vascular coverage in the superf

128 r intertwining was quantified by determining branching point density as a function of stromal depth.

129 Measured branching-point density was four times higher in the ant

130 nal branch-point prediction or for empirical branch-point determination.

131 three functionally distinct regions: axonal branch points, distal axons, and the remaining axon shaf

132 which had unusual chain length distribution, branch point distribution, and granule morphology.

133 Through the use of organic branching points, divalent and trivalent DNA linkers wer

134 f its baseline value in vessels as far as 10 branch points downstream from the occlusion.

135 At each branching point during differentiation, interactions wit

136 We do so using an approach analogous to the "branch point effect", a mechanism observed in naturally

137 a positive flux control coefficient for the branch point enzyme 3-phosphoglycerate dehydrogenase (PG

138 nes encoding leucoanthocyanidin reductase, a branch point enzyme involved in the biosynthesis of 2,3-

139 d may lead to specialized regulation of this branch point enzyme.

140 hydroxycinnamate biosynthesis as a potential branch-point enzyme.

141 ntroduces an additional regulation for these branch point enzymes of terpene metabolism.

142 ,3)-glucosyl side chain with an average of 1 branch point every 3.8 glucose unit.

143 t was missing at atherosclerosis-susceptible branch points, exposing dense collagen-proteoglycan comp

144 ed APs, we did not observe any conduction or branch-point failures.

145 an initial increase in the proximity of the branch point followed by a progressive decrease.

146 The unprotonated peroxohemiacetal provides a branch point for a concerted deformylation mechanism; ho

147 t downstream effects, indicating a signaling branch point for controlling microtubule stability.

148 that formate, not formaldehyde, is the main branch point for methylotrophic metabolism in M. extorqu

149 ore the significance of a nick adjacent to a branch point for Mus81-Mms4 incision.

150 )c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage-commitment pathways fr

151 phosphate synthase bienzyme is an important branch point for the histidine and nucleotide biosynthet

152 se (ITPK1) is a key regulatory enzyme at the branch point for the synthesis of inositol hexakisphosph

153 Consequently, the branch point for the synthesis of mono- and dicyclic car

154 sis of sulfone adducts that could be used as branch points for further diversification.

155 rmation of a C-H agostic complex that is the branching point for the productive and unproductive path

156 from E286, which is believed to serve as the branching point for the proton transport in the pumping

157 n sequence would allow for an additional new branching point for the synthesis of bacteriochlorophyll

158 In vitro EC branch point formation, EC invasion, and EC migration as

159 ure results, there was significantly more EC branch point formation, EC invasion, and EC migration as

160 (RNP) complexes for splice-site recognition, branch-point formation and catalysis.

161 quantified the morphological variability of branch points from two-photon images of rat CA1 pyramida

162 though the E286 side chain of subunit I is a branching point from which protons are shuttled either t

163 olar cell and transistor devices, moving the branching point further from the backbone was beneficial

164 removes multiple glutamate residues and the branch point glutamate from the side chains of porcine b

165 quely metabolizes the gamma-carboxyl linked, branch point glutamate.

166 The strategy of inserting a covalent branch point in a peptide can improve its antimicrobial

167 e or 19-O-acetylhorhammericine, represents a branch point in alkaloid biosynthesis.

168 Pyruvate constitutes a critical branch point in cellular carbon metabolism.

169 A [2Fe-2S] ferredoxin is a critical branch point in electron flow from Photosystem I toward

170 diate chanoclavine-I aldehyde 1 represents a branch point in ergot biosynthesis.

171 For direct validation, we study a metabolic branch point in Escherichia coli and experimentally conf

172 with three other enzymes at the first major branch point in fatty acid biosynthesis.

173 [2-(13)C]Phosphoenolpyruvate, a key branch point in gluconeogenesis and glycolysis, was moni

174 study elucidates for the first time a mapped branch point in HPV16 genome involved in viral oncogene

175 ts to explain this have focused on finding a branch point in insulin signaling where hepatic glucose

176 or signal strength, are responsible for this branch point in the B-cell terminal differentiation path

177 copene to gamma- or beta-carotene is a major branch point in the biosynthesis of carotenoids in photo

178 gration arrest occurs below the first stable branch point in the developing arbor.

179 biogenesis possibly via its involvement at a branch point in the endocytic pathway that facilitates s

180 Here, we report a branch point in the insulin signaling pathway that may a

181 s naringenin into 2-hydroxynaringenin, a key branch point in the P1-controlled pathway and the first

182 copper present) define the regioselectivity branch point in the sequence.

183 reactions to generate chorismate, a critical branch point in the synthesis of the aromatic amino acid

184 ilon)-methyl lysine demethylases, identifies branch points in 2OG-dependent oxygenase evolution and d

185 Dislocations are associated, as usual, with branch points in a phase field, whereas disclinations ar

186 Branch points in apical trees exhibit wide ranges of siz

187 se of dendritic protrusions and at dendritic branch points in cultured hippocampal neurons--a distrib

188 retinal vessel width relationship at vessel branch points in fundus images is an important biomarker

189 matic method to measure the vessel widths at branch points in fundus images.

190 podia originated at Arp2/3 complex-dependent branch points in lamellipodia, thus providing a mechanis

191 Allosteric regulation often controls key branch points in metabolic processes.

192 ons of Ca(2+) wave hot spots in general, and branch points in particular, are specially equipped for

193 ate synthases (IDS) are situated at critical branch points in terpene biosynthesis, producing the pre

194 (HSD) function as key regulatory enzymes at branch points in the aspartate amino acid pathway and ar

195 ation provides a new mechanism for producing branch points in the polymer.

196 gcD and SgcG unambiguously establishes a new branching point in chorismate metabolism.

197 toamide S (10), demonstrates 10 as a pivotal branching point in notoamide biosynthesis.

198 ndrial pyruvate carrier sits at an important branching point in nutrient metabolism and that it is an

199 led (DVL) is a key scaffolding protein and a branching point in Wnt signaling pathways.

200 e identified an increased number of dendrite branching points in CA1 and CA2 hippocampal neurons asso

201 can intrinsically generate frequent, random branching points in each growing fibril.

202 y ent-beyeran-16-yl carbocation (7) is a key branch point intermediate in mechanistic schemes to rati

203 (beta1-2)Man(alpha1-3)]ManGlcNAc(2) is a key branch point intermediate in the insect N-glycosylation

204 osaminyltransferase I (GNT-I) contributes to branch point intermediate production and can potentially

205 1-3)]ManGlcNAc(2), demonstrating its role in branch point intermediate production and its ability to

206 ing a secondary amine and leading to the key branch-point intermediate (S)-reticuline and (ii) downst

207 P) and geranylgeranyl diphosphate (GGPP) are branch point intermediates of isoprenoid biosynthesis.

208 orhammericine, will help illuminate how this branch point is controlled in C. roseus.

209 is a constant of 0.252, and the fraction of branch points is 0.237.

210 ments with natural waters indicated that the branching point is reached over prechlorine exposures (1

211 s of irreversible and discrete developmental branch points, is now understood to exist as a collectio

212 directed microtubule growth through dendrite branch points jeopardizes uniform microtubule polarity,

213 he hydroxyl positions (5', 3', or 2') at the branch-point junction.

214 of four consecutive enzymes around the main branch point leading to lignin precursors was investigat

215 of IL-15 production occurring at the pre-DC branch point, leading to the generation of both IL-15(+)

216 hich SF1 binding affinity data, validated by branch point mapping, were iteratively incorporated into

217 The touch neuron synaptic branch point may act as a sorting area to regulate growt

218 lux and enzyme membrane localization via the branch point metabolic node that mediates lipid flux thr

219 convert phenylalanine to p-coumaroyl CoA, a branch point metabolite from which many phenylpropanoids

220 n of 1-deoxy-d-xylulose 5-phosphate (DXP), a branch point metabolite in isoprenoid biosynthesis, and

221 ized from 5-aminoimidazole ribotide (AIR), a branch point metabolite of purine and thiamine biosynthe

222 emical and topological properties arise from branch-point nucleotides harboring vicinal 2',5'- and 3'

223 Branch point numbers and density and especially higher o

224 when evolutionary attractors, repellors and branching points occur and how this depends on whether t

225 e conduction path for angled gaps and at the branch point of a bifurcated gap.

226 olled cytosolic enzyme situated at a crucial branch point of central plant metabolism.

227 itch in activity that controls this critical branch point of ergot alkaloid biosynthesis.

228 CCP5 was proposed to selectively cleave the branch point of glutamylated tubulin, based on studies i

229 entify Notch as a therapeutically actionable branch point of metabolic signaling at which Akt activat

230 This observation may help to elucidate the branch point of TGFbeta signaling that leads to skewed T

231 via BA and SA, and therefore implies a novel branch point of the general phenylpropanoid pathway.

232 it catalyses the transfer of glucose to the branch point of the hexasaccharide O-linked to the serin

233 umulation of intermediate metabolites at the branch point of the mevalonate pathway.

234 al soma arrest occurs below the first stable branch point of the nascent dendrite.

235 vl) is a scaffold protein that serves as the branch point of these pathways.

236 or understanding and controlling the central branch point of this pharmacologically important group o

237 of cilia, the mother-bud neck of yeast, and branch points of filamentous fungi and dendritic spines,

238 ng, such as wide-necked aneurysms located at branch points of major vessels, large saccular aneurysms

239 The mannose branch points of N-linked oligosaccharides are apparentl

240 arotids but also in the lesser curvature and branching point of the aortic arch in mice as well as hu

241 It occupies a key position at the branching point of two metabolic pathways: the tryptopha

242 flow of beta-carotene through this important branching point of vitamin A metabolism.

243 ultiple sterols in vitro, establishing novel branching points of cholesterol synthesis.

244 s in which the ureter moves from its initial branch point on the nephric duct (ND) to its final inser

245 Thus, the imine is at a branch point on the reaction pathway.

246 To map precisely the location of branch points on a genomic scale, we developed LaSSO (La

247 he effect of the position of the alkyl-chain branching point on the thin-film morphology was investig

248 DCs were closely associated with nerve fiber branching points, penetrating the basement membrane and

249 iation has been used for characterization of branching points, peripheral substitutions, and partial

250 uracy than algorithms used for computational branch-point prediction or for empirical branch-point de

251 Such branch points present favorable gene targets for redirec

252 R-dependent [Ca(2+)](i) rises are greater at branch points raises the possibility that this novel Ca(

253 is process preferentially occurs at arterial branch points, reflecting a regional variation in lipopr

254 1-Mms4 occurs in a fashion determined by the branch point, regardless of the position of an upstream

255 , the sequence motifs found in the potential branch-point region differed between retained and consti

256 We identified AACAAAC as the preferred branch point sequence (BPS) and an adenosine at nt 385 (

257 s is largely due to intron 3 variants in the branch point sequence (BPS) and polypyrimidine tract.

258 int-binding region (BBR) of U2 snRNA and the branch point sequence (BPS) in the intron is essential f

259 Splicing factor 1 (SF1) binds to the branch point sequence (BPS) of mammalian introns and is

260 The highly conserved branch point sequence (BPS) of UACUAAC in Saccharomyces

261 ract of the intron, recruits U2 snRNP to the branch point sequence by interacting with the U2 snRNP p

262 ine at position 7, and the 5' splice site-to-branch point sequence context.

263 Recruitment of U2 snRNP to the branch point sequence of introns is a necessary step in

264 we have determined that yeast BBP binds the branch point sequence UACUAAC with highest affinity and

265 The predicted branch point sequences of Neurospora introns are much cl

266 ld be useful to validate introns and uncover branch-point sequences in any eukaryote, and it could be

267 promote U2 small nuclear RNP binding to the branch-point sequences of introns through interaction wi

268 el to accommodate sequences with and without branch point sites.

269 but also maintain a preferential position at branch points, sites of vessel growth.

270 on, cell-cell adhesion, and the formation of branching point structures are considered hallmarks of a

271 F-1) to induce EC migration and formation of branching point structures.

272 which mediated EC migration and formation of branching point structures.

273 ration, cell-cell adhesion, and formation of branching point structures.

274 in decreased dendritic length and number of branching points, suggesting an inverted U-shape respons

275 and localization of Apc2-GFP and Apc-RFP to branch points suggests that these proteins work together

276 (approximately 25%) in the number of neurite branch points, supporting the results of the SAFE analys

277 fewer and thinner aortic sprouts with fewer branch points than controls because of impaired endothel

278 on-canonical in that it contains a predicted branch point that is 141 nucleotides from the 3'-splice

279 c splicing silencer (ISS) adjacent to the M1 branch point that is sufficient to confer Tra2-dependent

280 At atherosclerosis-susceptible vascular branch points, the absence of a luminal elastin barrier

281 We observed that the number of branch points, the total branch length, and the number a

282 D RNA can guide modification at the pre-mRNA branch point, thus silencing its expression and inducing

283 and translocate the intron downstream of the branch point to destabilize branching-specific factors a

284 , particularly those acting at key metabolic branch points, to "fine tune" catalysis.

285 l junctions, which are AT- or GC-rich at the branch points, to show that binding of the peptide KWWCR

286 Many of the pathways initiated at this branch point transform chorismate using an MST enzyme.

287 e dehydrogenase (ASADH) catalyzes a critical branch point transformation in amino acid bio-synthesis.

288 activity and an ATP-dependent bi-directional branch-point translocation activity on a synthetic four-

289 tion, an in-depth analysis of this metabolic branching point was so far lacking.

290 species representing important evolutionary branch points, we have analyzed the composition and orga

291 Before this branching point, we could detect the signature of an imm

292 Eighty percent of branch points were formed, and 70% of all fibers reached

293 DS were located on the repeat units near the branching points, whereas the OS substituents in the OS

294 roximately 4% of the isolated chains contain branch points with no apparent dependence on proteasome

295 1% of chains isolated with TUBEs contain Ub branch points, with this value rising to approximately 4

296 cyclohexa-2-ene-1,4-dione may serve as a key branching point, with chloramines promoting the formatio

297 duce transient lariat structures fastened by branch points within introns.

298 XTRINASE1, a debranching enzyme that cleaves branch points within starch molecules, is at the same le

299 e origin of nonrandom or clustered alpha-1,6 branch-points within the major component of starch, amyl

300 s such as an Sm site, a 5' splice site and a branch point, within the newly identified TER sequences.