ライフサイエンスコーパス: branch point

1 on every 75th carbon (74 methylenes between branch points).

2 be 10.9 +/- 1.2 kT (17.0 +/- 1.3 kT without branch points).

3 terically protected region downstream of the branch point.

4 lants to bypass the pathway at the arogenate branch point.

5 ANF has as an allosteric effect on a kinetic branch point.

6 ng occurs primarily at the predicted distant branch point.

7 ern after stable U2 snRNP association to the branch point.

8 ime unless the mother depolymerized past the branch point.

9 Watson-Crick base pairing with the 5' ss and branch point.

10 155 and promotes U2 snRNP recruitment to the branch point.

11 , while the N-terminal region can serve as a branch-point.

12 p moving and localize stably to synapses and branch points.

13 o ER-stress, indicating multiple development branch points.

14 hways and the factors affecting flux through branch points.

15 ly endosomes and recruit nucleation sites to branch points.

16 identified both canonical and exon-skipping branch points.

17 rafficking of secretory cargo near dendritic branch points.

18 ff-synaptic locations in the axon and axonal branch points.

19 roximal dendritic arbor, preferentially near branch points.

20 cal DNA and whose vertices correspond to the branch points.

21 ckage of viral reverse transcriptase at gRNA branch points.

22 motor protein steers growing microtubules at branch points.

23 , but not exclusively localized at dendritic branch points.

24 but few cold spots, are located at dendritic branch points.

25 ontinuum, passing through cellular nodes and branch points.

26 rowth might be particularly important beyond branch points.

27 defects in mitochondria fission at dendritic branch points.

28 lation of macrophages, which were located at branch points.

29 tubule nucleation sites localize at dendrite branch points.

30 ted, and do not aggregate normally at axonal branch points.

31 dextran) which also contain alpha-(1,3,6)Glc branch points.

32 g cells and in the correct identification of branch points.

33 nic, as they possess inorganic atoms at each branching point.

34 axon, 70 mum after the most distal dendritic branching point.

35 repare a highly crowded 1,2,3-cis configured branching point.

36 differences were also found at the pyruvate branching point.

37 0 and Q633 to establish a pivotal allosteric branching point.

38 mpetitive and clarifies decisions at pathway branching points.

39 ding sites emerged at the major evolutionary branching points.

40 lyzed for their length, area and quantity of branching points.

41 ) and dimethylthexylsilyl ether (TDS) at key branching points.

42 rious patterns of alpha-d-Gal and beta-d-Gal branching points.

43 rotecting groups made it possible to install branching points.

44 cantly longer sprouts with smaller angles at branching points.

45 ch as the total tube length or the number of branching points.

46 ensities of vessel area, length, number, and branch point (A(v), L(v), N(v), and Br(v)).

47 positions-donor and acceptor splice sites, a branch point, a polypyrimidine tract and suitable splici

48 utations cluster in a pocket surrounding the branch point adenosine, suggesting a competitive mode of

49 rick pairing with the 5' splice site and the branch-point adenosine.

50 distinct arterial EC population at vascular branch points (aEC1) exhibits ligand-independent S1PR1/B

51 1PR1/B-arrestin coupling was observed in non-branch point aEC2 cells that exhibit an inflammatory gen

52 p the interactions of the ssDNA tail and the branch point along the helicase and Zn-binding domains,

53 Control at this branch point also prevents accumulation of intermediates

54 having a short distance between their lariat branch point and 3' splice site, which is necessary and

55 that the highly conserved region between the branch point and 3'-splice site is primarily unstructure

56 ot interaction between a C-rich bulge at the branch point and a G-rich bulge in the main helix.

57 engineered U7 snRNAs targeted to the cryptic branch point and an exonic splicing enhancer, U7.BP + 62

58 plice site, aberrant 5' splice site, cryptic branch point and an exonic splicing enhancer.

59 enzymes function at the N-glycan processing branch point and are major factors determining the net o

60 Knock-outs of regulators of this metabolic branch point and of its central enzyme, pyruvate kinase

61 res, including a more distal location of the branch point and presence of a pyrimidine immediately be

62 repeats use cryptic 3'SSs downstream of the branch point and provide both a mechanistic model consis

63 A UUUUCCCCCC motif situated between the branch point and the 3' splice site is crucial for inclu

64 pin itself showed enrichment at hyphal tips, branch points and anucleate regions.

65 ng analysis reveals that MAP7 is enriched at branch points and colocalizes with stable microtubules,

66 the vasculature is preferentially located at branch points and curves where blood flow is disturbed a

67 d number of capillary segments and capillary branch points and decreased complexity of the glomerular

68 in less organized microtubules at dendritic branch points and decreased dendritogensis.

69 FMRP in NL/MSO neurons often accumulates at branch points and enlarged distal tips, loci known to be

70 Crossing points are distinguished from branch points and excluded.

71 ex to both "prune" daughter filaments at the branch points and inhibit new actin assembly.

72 The vessels had few branch points and many vascular anastomotic connections

73 ined by increased ER complexity at dendritic branch points and near dendritic spines.

74 ue, Kv1.1, cause hyperexcitability near axon branch points and nerve terminals, thereby leading to un

75 xon are very diverse structures encompassing branch points and numerous presynaptic terminals with un

76 raction, vessel length and number, number of branch points and perfusion status of the newly formed v

77 some neurons collateralize, what determines branch points and projection foci, and how this impacts

78 glomerular capillary segments and capillary branch points and restored complexity of the capillary n

79 length of dendritic wiring to the number of branch points and synapses.

80 t microtubule growth is directed at dendrite branch points and that kinesin-2, APC, and EB1 are likel

81 s were topologically more complex, with more branch points and tortuous dendritic paths.

82 multiple cortical columns, and to have >1000 branch points and total axon lengths up to 50 cm.

83 nic compartment, despite having thousands of branch points and total cable length >10 mm (Otopalik et

84 onsistent with this notion, Raw localizes to branch-points and promotes dendrite stabilization togeth

85 d flow: scaling of the distance to the first branching point and the probability distribution of the

86 the more complex songs of Bengalese finches, branching points and bidirectional transitions in song s

87 ated 2 weeks after birth triggers fewer duct branching points and fewer terminal end buds (TEBs) and

88 r number of lymphatic vessel end points, and branching points and increased inflammation-induced lymp

89 starch with a high DS occurred both near the branching points and the non-reducing ends.

90 olic pathway motifs (e.g., linear chains and branching points) and also under the conditions of fast

91 Cys despite an ester linkage at the C-extein branch point, and (d) an absolute requirement for the WC

92 ts exhibit abnormal placement of the neurite branch point, and defective synaptogenesis, characterize

93 rements were self-consistent across vascular branch points, and approximately followed a predicted po

94 uch as fibril diameter distribution, length, branch points, and fibril aggregations.

95 nct Golgi compartments in soma and dendritic branch points, and the specific distribution of GM130 de

96 gammaTub-green fluorescent protein (GFP) at branch points, and two functional readouts of dendritic

97 dal shape, showed reduced segment length and branching points, and reduced adhesion molecule and cons

98 the pathway, while the enzymes at the second branch point are recruited to RNA stress granules.

99 that biochemical steps before the monolignol branch point are shared between phenylpropene and lignin

100 l processing and that the properties of axon branch points are adjusted to maintain faithful transmis

101 -seq) reveals that introns with nonconsensus branch points are particularly sensitive to H2A.Z loss.

102 e activity, ER networks in soma and dendrite branch points are reduced and replaced by tubules, and E

103 Branching points are considered to be the risk points of

104 Branching points are detected on the vessel centerline i

105 ts were calculated for fluxes around the key branch point at Phe and revealed that phenylacetaldehyde

106 thesis utilizes Michael addition to create a branch point at the end of a PEG chain combined with car

107 eaching their final length and the number of branch points attained maximum values at 60% of maximum

108 At dendrite branch points, Axin and dsh colocalized with early endos

109 n, and provides genome-wide validation for a branch point-based scanning model for 3' splice site rec

110 that growing microtubule plus ends entering branch points be actively directed toward the cell body.

111 formate, an intermediate that serves as the branch point between assimilation (formation of biomass)

112 A represents a novel mechanistic node at the branch point between commitment to either Treg or Th17 l

113 This reaction sits at the branch point between the de novo pathway and the salvage

114 cell-to-endothelium transmission and also at branch points between a capillary and its tertiary arter

115 flexible mechanism of flux diversion at the branch-point between the anthocyanin and proanthocyanidi

116 lace these unconventional lymphocytes at the branching point between antigen-presenting cells and nat

117 cient polar bear lies almost directly at the branching point between polar bears and brown bears, elu

118 Duplex formation between the branch point-binding region (BBR) of U2 snRNA and the br

119 The branch point (BP) adenosine attacks the 5'SS, producing

120 bilizes the interaction between U2 snRNP and branch point (BP) on the pre-mRNA.

121 nuclear ribonucleoprotein (U2AF) facilitates branch point (BP) recognition and formation of lariat in

122 Sequences 5' from the branch point (BP) region strongly influence drug sensiti

123 e intron 30 variant changes a weak alternate branch point (BP) to a strong BP.

124 Nucleation sites concentrate at dendrite branch points, but how they localize is not known.

125 that growing microtubules navigate dendrite branch points by turning the same way, toward the cell b

126 uctures with different linkage positions and branching points by direct-infusion negative ESI-MS(n).

127 NCE STATEMENT The impedance mismatch at axon branch points can impede spike propagation.

128 Mapping of the intron 4 branch point confirmed that branching occurs primarily a

129 ropionate group is the previously postulated branching point connecting proton transfer to the E-path

130 erestingly, mutating BDF2 5' splice site and branch point consensus sequences partially suppresses th

131 t that even subtle membrane readjustments at branch points could drastically alter the ability of syn

132 A branching point could be installed by using 9-fluorenylm

133 sors of splice-site mutations, and an intron branch-point crosslink, map to a large cavity formed by

134 IN is an essential adaptor downstream of the branch point defined by the panr2 mutation in NEMO.

135 rine retinal vasculature, elevating vascular branch point density and vascular coverage in the superf

136 r intertwining was quantified by determining branching point density as a function of stromal depth.

137 Measured branching-point density was four times higher in the ant

138 nal branch-point prediction or for empirical branch-point determination.

139 which had unusual chain length distribution, branch point distribution, and granule morphology.

140 Through the use of organic branching points, divalent and trivalent DNA linkers wer

141 We do so using an approach analogous to the "branch point effect", a mechanism observed in naturally

142 a positive flux control coefficient for the branch point enzyme 3-phosphoglycerate dehydrogenase (PG

143 nes encoding leucoanthocyanidin reductase, a branch point enzyme involved in the biosynthesis of 2,3-

144 d may lead to specialized regulation of this branch point enzyme.

145 hydroxycinnamate biosynthesis as a potential branch-point enzyme.

146 ntroduces an additional regulation for these branch point enzymes of terpene metabolism.

147 bition of the aspartate pathway at different branch-point enzymes leads to clearance of chronic infec

148 In PVD soma and dendrite branch points, ER tubules connect to form networks.

149 ,3)-glucosyl side chain with an average of 1 branch point every 3.8 glucose unit.

150 ed APs, we did not observe any conduction or branch-point failures.

151 The unprotonated peroxohemiacetal provides a branch point for a concerted deformylation mechanism; ho

152 t downstream effects, indicating a signaling branch point for controlling microtubule stability.

153 that formate, not formaldehyde, is the main branch point for methylotrophic metabolism in M. extorqu

154 ore the significance of a nick adjacent to a branch point for Mus81-Mms4 incision.

155 )c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage-commitment pathways fr

156 phosphate synthase bienzyme is an important branch point for the histidine and nucleotide biosynthet

157 se (ITPK1) is a key regulatory enzyme at the branch point for the synthesis of inositol hexakisphosph

158 1,2-DHIQs are an attractive branch point for the synthesis of IQs, but because of th

159 sis of sulfone adducts that could be used as branch points for further diversification.

160 rmation of a C-H agostic complex that is the branching point for the productive and unproductive path

161 n sequence would allow for an additional new branching point for the synthesis of bacteriochlorophyll

162 can serve as differentiation checkpoints or branching points for channeling cells to more than one l

163 In vitro EC branch point formation, EC invasion, and EC migration as

164 ure results, there was significantly more EC branch point formation, EC invasion, and EC migration as

165 (RNP) complexes for splice-site recognition, branch-point formation and catalysis.

166 quantified the morphological variability of branch points from two-photon images of rat CA1 pyramida

167 olar cell and transistor devices, moving the branching point further from the backbone was beneficial

168 removes multiple glutamate residues and the branch point glutamate from the side chains of porcine b

169 quely metabolizes the gamma-carboxyl linked, branch point glutamate.

170 chains (151 H(2)O per chain at 298 K), where branch points have 3 SHBs and termination points have 1

171 The strategy of inserting a covalent branch point in a peptide can improve its antimicrobial

172 e or 19-O-acetylhorhammericine, represents a branch point in alkaloid biosynthesis.

173 Pyruvate constitutes a critical branch point in cellular carbon metabolism.

174 The assembly of enzymes at the first branch point in de novo purine biosynthesis is coordinat

175 diate chanoclavine-I aldehyde 1 represents a branch point in ergot biosynthesis.

176 For direct validation, we study a metabolic branch point in Escherichia coli and experimentally conf

177 [2-(13)C]Phosphoenolpyruvate, a key branch point in gluconeogenesis and glycolysis, was moni

178 study elucidates for the first time a mapped branch point in HPV16 genome involved in viral oncogene

179 ts to explain this have focused on finding a branch point in insulin signaling where hepatic glucose

180 gration arrest occurs below the first stable branch point in the developing arbor.

181 biogenesis possibly via its involvement at a branch point in the endocytic pathway that facilitates s

182 Here, we report a branch point in the insulin signaling pathway that may a

183 s naringenin into 2-hydroxynaringenin, a key branch point in the P1-controlled pathway and the first

184 copper present) define the regioselectivity branch point in the sequence.

185 reactions to generate chorismate, a critical branch point in the synthesis of the aromatic amino acid

186 ilon)-methyl lysine demethylases, identifies branch points in 2OG-dependent oxygenase evolution and d

187 Dislocations are associated, as usual, with branch points in a phase field, whereas disclinations ar

188 Branch points in apical trees exhibit wide ranges of siz

189 sed on soma size and the number of dendritic branch points in combination with SMI-32 immunoreactivit

190 retinal vessel width relationship at vessel branch points in fundus images is an important biomarker

191 matic method to measure the vessel widths at branch points in fundus images.

192 Allosteric regulation often controls key branch points in metabolic processes.

193 ons of Ca(2+) wave hot spots in general, and branch points in particular, are specially equipped for

194 ate synthases (IDS) are situated at critical branch points in terpene biosynthesis, producing the pre

195 (HSD) function as key regulatory enzymes at branch points in the aspartate amino acid pathway and ar

196 toamide S (10), demonstrates 10 as a pivotal branching point in notoamide biosynthesis.

197 ndrial pyruvate carrier sits at an important branching point in nutrient metabolism and that it is an

198 ween the 2 different modes suggests that the branching point in the mechanism is established by confo

199 led (DVL) is a key scaffolding protein and a branching point in Wnt signaling pathways.

200 e identified an increased number of dendrite branching points in CA1 and CA2 hippocampal neurons asso

201 can intrinsically generate frequent, random branching points in each growing fibril.

202 of Shot induces ectopic acentrosomal luminal branching points in the embryonic and larval tracheal TC

203 (beta1-2)Man(alpha1-3)]ManGlcNAc(2) is a key branch point intermediate in the insect N-glycosylation

204 osaminyltransferase I (GNT-I) contributes to branch point intermediate production and can potentially

205 1-3)]ManGlcNAc(2), demonstrating its role in branch point intermediate production and its ability to

206 thway takes place via conversion of a shared branch point intermediate to 8-ketocoformycin-[Formula:

207 ing a secondary amine and leading to the key branch-point intermediate (S)-reticuline and (ii) downst

208 orhammericine, will help illuminate how this branch point is controlled in C. roseus.

209 is a constant of 0.252, and the fraction of branch points is 0.237.

210 ments with natural waters indicated that the branching point is reached over prechlorine exposures (1

211 s of irreversible and discrete developmental branch points, is now understood to exist as a collectio

212 directed microtubule growth through dendrite branch points jeopardizes uniform microtubule polarity,

213 he hydroxyl positions (5', 3', or 2') at the branch-point junction.

214 of four consecutive enzymes around the main branch point leading to lignin precursors was investigat

215 of IL-15 production occurring at the pre-DC branch point, leading to the generation of both IL-15(+)

216 hich SF1 binding affinity data, validated by branch point mapping, were iteratively incorporated into

217 mental trajectories and show that trajectory branch points mark developmental decisions.

218 lux and enzyme membrane localization via the branch point metabolic node that mediates lipid flux thr

219 convert phenylalanine to p-coumaroyl CoA, a branch point metabolite from which many phenylpropanoids

220 n of 1-deoxy-d-xylulose 5-phosphate (DXP), a branch point metabolite in isoprenoid biosynthesis, and

221 ized from 5-aminoimidazole ribotide (AIR), a branch point metabolite of purine and thiamine biosynthe

222 ponsible for the production of chorismate, a branch point metabolite.

223 emical and topological properties arise from branch-point nucleotides harboring vicinal 2',5'- and 3'

224 ters (ie, cell area, network length, network branch points, number of networks, and average tube widt

225 Branch point numbers and density and especially higher o

226 olled cytosolic enzyme situated at a crucial branch point of central plant metabolism.

227 itch in activity that controls this critical branch point of ergot alkaloid biosynthesis.

228 pseudotemporal trajectories, 3 states and 1 branch point of fate transition for the germ cells were

229 CCP5 was proposed to selectively cleave the branch point of glutamylated tubulin, based on studies i

230 entify Notch as a therapeutically actionable branch point of metabolic signaling at which Akt activat

231 This observation may help to elucidate the branch point of TGFbeta signaling that leads to skewed T

232 via BA and SA, and therefore implies a novel branch point of the general phenylpropanoid pathway.

233 it catalyses the transfer of glucose to the branch point of the hexasaccharide O-linked to the serin

234 umulation of intermediate metabolites at the branch point of the mevalonate pathway.

235 al soma arrest occurs below the first stable branch point of the nascent dendrite.

236 vl) is a scaffold protein that serves as the branch point of these pathways.

237 or understanding and controlling the central branch point of this pharmacologically important group o

238 of cilia, the mother-bud neck of yeast, and branch points of filamentous fungi and dendritic spines,

239 ng, such as wide-necked aneurysms located at branch points of major vessels, large saccular aneurysms

240 Three less frequent types constitute the branch points of the network.

241 mate mutase (CM), an essential enzyme at the branch-point of the shikimate pathway, is required for t

242 arotids but also in the lesser curvature and branching point of the aortic arch in mice as well as hu

243 flow of beta-carotene through this important branching point of vitamin A metabolism.

244 plicative decrease of currents at successive branching points of a tree and is found to be independen

245 ultiple sterols in vitro, establishing novel branching points of cholesterol synthesis.

246 s in which the ureter moves from its initial branch point on the nephric duct (ND) to its final inser

247 To map precisely the location of branch points on a genomic scale, we developed LaSSO (La

248 ally, the ability to assemble is enriched at branch points on several metabolic pathways.

249 he effect of the position of the alkyl-chain branching point on the thin-film morphology was investig

250 DCs were closely associated with nerve fiber branching points, penetrating the basement membrane and

251 iation has been used for characterization of branching points, peripheral substitutions, and partial

252 uracy than algorithms used for computational branch-point prediction or for empirical branch-point de

253 Such branch points present favorable gene targets for redirec

254 R-dependent [Ca(2+)](i) rises are greater at branch points raises the possibility that this novel Ca(

255 is process preferentially occurs at arterial branch points, reflecting a regional variation in lipopr

256 1-Mms4 occurs in a fashion determined by the branch point, regardless of the position of an upstream

257 , the sequence motifs found in the potential branch-point region differed between retained and consti

258 me assembly and splicing proofreading at the branch-point region.

259 the probability of syllable transitions at "branch points" (relatively complex sequences that are fo

260 Reliability of spike propagation across branch points remains an open question and is especially

261 s included: tortuousity, width gradient, and branching point retinal groupings; SNPs known to be asso

262 We identified AACAAAC as the preferred branch point sequence (BPS) and an adenosine at nt 385 (

263 int-binding region (BBR) of U2 snRNA and the branch point sequence (BPS) in the intron is essential f

264 Splicing factor 1 (SF1) binds to the branch point sequence (BPS) of mammalian introns and is

265 ine at position 7, and the 5' splice site-to-branch point sequence context.

266 rsor messenger RNA 5' splice site (5'SS) and branch point sequence, associates with the U4/U6.U5 tri-

267 ld be useful to validate introns and uncover branch-point sequences in any eukaryote, and it could be

268 Exceptional points are branch point singularities in the parameter space of a s

269 Branch-point singularities known as exceptional points (

270 on, cell-cell adhesion, and the formation of branching point structures are considered hallmarks of a

271 F-1) to induce EC migration and formation of branching point structures.

272 which mediated EC migration and formation of branching point structures.

273 ration, cell-cell adhesion, and formation of branching point structures.

274 in decreased dendritic length and number of branching points, suggesting an inverted U-shape respons

275 and localization of Apc2-GFP and Apc-RFP to branch points suggests that these proteins work together

276 (approximately 25%) in the number of neurite branch points, supporting the results of the SAFE analys

277 fewer and thinner aortic sprouts with fewer branch points than controls because of impaired endothel

278 Thus, Lyn operates at a branch point that determines the nature of the B cell re

279 on-canonical in that it contains a predicted branch point that is 141 nucleotides from the 3'-splice

280 We observed that the number of branch points, the total branch length, and the number a

281 and translocate the intron downstream of the branch point to destabilize branching-specific factors a

282 he endonuclease incises adjacent to junction branch points to achieve resolution.

283 , particularly those acting at key metabolic branch points, to "fine tune" catalysis.

284 l junctions, which are AT- or GC-rich at the branch points, to show that binding of the peptide KWWCR

285 Many of the pathways initiated at this branch point transform chorismate using an MST enzyme.

286 e quantification of multiply GlyGly-modified branch-point ubiquitin.

287 r approach is the installation of additional branching points using recombinant MGAT4 and MGAT5 in co

288 iplines, as the disease-associated alternate branch point utilization defined in the report may be th

289 tion, an in-depth analysis of this metabolic branching point was so far lacking.

290 species representing important evolutionary branch points, we have analyzed the composition and orga

291 Before this branching point, we could detect the signature of an imm

292 DS were located on the repeat units near the branching points, whereas the OS substituents in the OS

293 roximately 4% of the isolated chains contain branch points with no apparent dependence on proteasome

294 lariat formation, enabling identification of branch points with single-nucleotide resolution, and pro

295 Both dsh and Axin localized to branch points, with dsh upstream of Axin.

296 1% of chains isolated with TUBEs contain Ub branch points, with this value rising to approximately 4

297 cyclohexa-2-ene-1,4-dione may serve as a key branching point, with chloramines promoting the formatio

298 duce transient lariat structures fastened by branch points within introns.

299 XTRINASE1, a debranching enzyme that cleaves branch points within starch molecules, is at the same le

300 s such as an Sm site, a 5' splice site and a branch point, within the newly identified TER sequences.