ライフサイエンスコーパス: branched chain

1 lysis indicates the presence of K48 in these branched chains.

2 asome-associated deubiquitinase, cleaves K48 branched chains.

3 as single chains and, to a lesser degree, as branched chains.

4 lightly higher M(w) but composing of shorter branched chains.

5 ) of ubiquitin in polymers seems to exist as branched chains.

6 er, the 2-oxoglutarate dehydrogenase (OGDH), branched-chain 2-oxoacid dehydrogenase (BCKDH), and pyru

7 hy dogs (P < 0.05) with the exception of the branched chain AA valine, which was elevated in diabetic

8 gensis metabolites, bile acids, and elevated branched chain AA).

9 metabolism, arginine/proline metabolism, and branched-chain AA (BCAA) metabolism at baseline.

10 to determine if supplementing VLP diets with branched-chain AA (BCAA) would reverse the negative effe

11 rations of amino acids (AAs), in particular, branched chain AAs (BCAAs), are often found increased in

12 ytosis response is activated through reduced branched-chain AAs (leucine, isoleucine, valine).

13 In the case of branched-chain acids, the exchange is restricted to abou

14 Acyl CoA Oxidase 2 (ACOX2) encodes branched-chain acyl-CoA oxidase, a peroxisomal enzyme be

15 and even-alkyl chain alkylresorcinols (AR), branched-chain alkylresorcinols (bcAR) and methylalkylre

16 Branched chain alpha-keto acid dehydrogenase enzyme acti

17 coupled receptor, and DBT, a subunit of the branched chain alpha-keto acid dehydrogenase that is req

18 tes, at least in part due to accumulation of branched chain alpha-keto acids.

19 This gene encodes the E2 subunit of the branched-chain alpha-keto acid dehydrogenase (BCKDH) com

20 assess both BCAA aminotransferase (BCAT) and branched-chain alpha-keto acid dehydrogenase complex (BC

21 or) to alter alkane Cn and expression of the branched-chain alpha-keto acid dehydrogenase complex and

22 pyruvate carboxykinase, aconitate hydratase, branched-chain alpha-keto acid dehydrogenase E1 componen

23 Branched-chain alpha-keto acids (BCKAs) are catabolites

24 , encoding an activator of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) respo

25 Branched-chain alpha-ketoacid dehydrogenase (BCKDH) cata

26 The mitochondrial branched-chain alpha-ketoacid dehydrogenase complex (BCK

27 meostasis is controlled by the mitochondrial branched-chain alpha-ketoacid dehydrogenase complex (BCK

28 ally, silencing the expression of a putative branched-chain alpha-ketoacid dehydrogenase E1 beta-subu

29 entified 22 UBE3B interactors and found that branched-chain alpha-ketoacid dehydrogenase kinase (BCKD

30 d an accumulation of metabolites upstream of branched-chain alpha-ketoacid oxidation, consistent with

31 nificant activity toward other straight- and branched-chain alpha-ketoacids, greatly expanding the ra

32 REBP was rapidly inhibited when incubated in branched-chain alpha-ketoacids, saturated and unsaturate

33 le, photorespiration, and the degradation of branched-chain alpha-ketoacids.

34 y be assembled from two distinct moieties, a branched-chain amine that is acylated with a novel polyu

35 convergence of microRNAs and TFs within the branched chain amino acid (BCAA) metabolic pathway, poss

36 electrophoresis (MD-CE) assay for monitoring branched chain amino acid (BCAA) uptake/release dynamics

37 acid metabolism were evident from increased branched chain amino acid and asparagine levels and alte

38 c pathways such as the citric acid cycle and branched chain amino acid degradation.

39 oteins: the H-protein and the E2 subunits of branched chain amino acid dehydrogenase (BCDH) and alpha

40 a 10 gene cluster responsible for increased branched chain amino acid fermentation in the co-culture

41 e disease (MSUD) is an inherited disorder of branched chain amino acid metabolism presenting with neo

42 ained before and 7 hours after a single oral branched chain amino acid mixture enriched with leucine

43 Branched chain amino acid supplements may be of value in

44 th microbial function; 13 pathways including branched chain amino acid synthesis were significantly e

45 Lung tumors catabolize circulating branched chain amino acids (BCAA) to extract nitrogen fo

46 rsity includes: inflammation, degradation of branched chain amino acids (BCAA), and regulation of per

47 Branched chain amino acids (BCAAs) are building blocks f

48 fat, or high-fat diet supplemented with 1.5X branched chain amino acids (BCAAs) by replacing carbohyd

49 ith varying doses of leucine or a mixture of branched chain amino acids (BCAAs) on myofibrillar prote

50 High-protein diets, rich in methionine and branched chain amino acids (BCAAs), apparently reduce li

51 insulin were to reduce plasma levels of the branched chain amino acids (BCAs) leucine/isoleucine and

52 reased in presymptomatic HD sheep, including branched chain amino acids (isoleucine, leucine and vali

53 Branched chain amino acids (leucine, isoleucine and vali

54 ), and enrichment in metabolic pathways (eg, branched chain amino acids and arginine biosynthesis) an

55 r metabolite biomarkers of diabetes, such as branched chain amino acids and aromatic amino acids, sug

56 t differences in the amounts of aromatic and branched chain amino acids between the groups as well as

57 ylase, and 3-methylcrotonyl-CoA carboxylase (branched chain amino acids catabolism).

58 that C. difficile preferentially catabolizes branched chain amino acids during CDI.

59 The branched chain amino acids leucine, isoleucine, valine,

60 i produced leucine, isoleucine and valine as branched chain amino acids when grown on LBG hydrolysate

61 ysophosphatidylethanolamines, 5 ceramides, 3 branched chain amino acids, and 9 neurotransmitters).

62 Ceramides, lysolipids, aromatic amino acids, branched chain amino acids, and stress-induced amino aci

63 ficits in enzymes required for catabolism of branched chain amino acids, ketones, and lactate, along

64 ase in acetate, lactate, succinate, alanine, branched chain amino acids, trimethylamine and a progres

65 coneogenesis and oxidations of glutamine and branched chain amino acids, which together sustain the n

66 lycolysis/gluconeogenesis, and metabolism of branched chain amino acids.

67 so decreased the expression of mitochondrial branched chain amino transferase (BCAT) which produces K

68 abolic disorder, affecting the metabolism of branched chain amino-acids (Valine, Leukine, Isoleukine)

69 ed esters arising from partial catabolism of branched chain amino-acids.

70 ta are currently available on the effects of branched-chain amino acid (BCAA) and branched-chain keto

71 CodY is a branched-chain amino acid (BCAA) and GTP sensor and a gl

72 synthase (AHAS) catalyzes the first step of branched-chain amino acid (BCAA) biosynthesis, a pathway

73 e (BCKDH) catalyzes the critical step in the branched-chain amino acid (BCAA) catabolic pathway and h

74 We previously described abnormalities in the branched-chain amino acid (BCAA) catabolic pathway as a

75 ways involved in inflammation, fibrosis, and branched-chain amino acid (BCAA) catabolism; systemic ma

76 augment BCKDC flux have been shown to reduce branched-chain amino acid (BCAA) concentrations in vivo.

77 associated with reduced or borderline plasma branched-chain amino acid (BCAA) concentrations.

78 d correlations among metabolites involved in branched-chain amino acid (BCAA) degradation, trimethyla

79 Branched-chain amino acid (BCAA) metabolism plays a cent

80 ogenase (BCKDH) complex, a core component of branched-chain amino acid (BCAA) metabolism.

81 production, while it does not contribute to branched-chain amino acid (BCAA)-derived aldehyde biosyn

82 ing utilization of free fatty acid (FFA) and branched-chain amino acid (BCAA).

83 Branched-chain amino acid (BCAA; valine, leucine and iso

84 Evidence suggests a role for impaired branched-chain amino acid (BCAAs; isoleucine, leucine, v

85 sult from alanine aminotransferase (ALT) and branched-chain amino acid aminotransferase (BcAT)'s high

86 and proteins, including ones in pathways of branched-chain amino acid and fatty acid metabolism and

87 Here, we highlight collaboration in branched-chain amino acid and pantothenate (vitamin B5)

88 olutionary age analysis revealed that, while branched-chain amino acid and proline catabolism are ver

89 and raised the root and shoot levels of the branched-chain amino acid biosynthesis intermediate 2-ox

90 . 2.2.1.6), which is the first enzyme in the branched-chain amino acid biosynthesis pathway.

91 cid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway.

92 l was based, demonstrated the involvement of branched-chain amino acid biosynthesis, ascorbate and al

93 A-B27-negative AAU, including an increase of branched-chain amino acid biosynthesis, that reflects di

94 by metformin exposure, including changes in branched-chain amino acid catabolism and cuticle mainten

95 Collectively, these results indicate that branched-chain amino acid catabolism contributes to TAG

96 yl-CoA (HMG-CoA) lyase (HMGL) is involved in branched-chain amino acid catabolism leading to acetyl-C

97 hat several Arabidopsis mutants deficient in branched-chain amino acid catabolism or fatty acid metab

98 It also increases our knowledge of the role branched-chain amino acid catabolism plays in seed devel

99 Increased plasma branched-chain amino acid concentrations are associated

100 the identification and characterization of a branched-chain amino acid decarboxylase, which would app

101 rior to this study, the relationship between branched-chain amino acid degradation (named for leucine

102 Furthermore, the Hadza GM is equipped for branched-chain amino acid degradation and aromatic amino

103 Major metabolic pathways were branched-chain amino acid metabolism (partially independ

104 pts surrounding the current understanding of branched-chain amino acid metabolism and its role in can

105 Adiponectin corrected the altered branched-chain amino acid metabolism caused by HFD and c

106 deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affect

107 spiration, an ornithine-glutamine shunt, and branched-chain amino acid metabolism were hypothesized a

108 zed the condensation of two intermediates in branched-chain amino acid metabolism, isovaleryl-Coenzym

109 tion of proteins in fatty acid oxidation and branched-chain amino acid metabolism.

110 ehydrogenase (PDH) as well as fatty acid and branched-chain amino acid oxidation.

111 t-chain dicarboxylacylcarnitines (SCDA), and branched-chain amino acid plasma biomarkers were indepen

112 of genes related to vitamin B6 synthesis and branched-chain amino acid synthesis (Q(fdr) < .05).

113 ing dihydroxyacid dehydratase, important for branched-chain amino acid synthesis.

114 IDH1 mutation and decreased activity of the branched-chain amino acid transaminase 1 (BCAT1) enzyme.

115 how that glioblastoma express high levels of branched-chain amino acid transaminase 1 (BCAT1), the en

116 on of its direct targets including the BCAT2 branched-chain amino acid transaminase 2) gene.

117 ic glucosinolate biosynthesis in tandem with BRANCHED-CHAIN AMINO ACID TRANSAMINASE4, which is involv

118 scovered a potential causal link between the branched-chain amino acid transferase BCAT-1 and the neu

119 uced miR-276-5p fine-tunes the expression of branched-chain amino acid transferase to terminate the r

120 Reduced branched-chain amino acid uptake and increased accumulat

121 thesized that protein, essential amino acid, branched-chain amino acid, and leucine intakes are assoc

122 ave been the subject of great scrutiny, as a branched-chain amino acid, Leu can be catabolized within

123 sted the effects of a genetic determinant of branched-chain amino acid/aromatic amino acid ratio on c

124 ultivariate analyses identified preoperative branched-chain amino acid/tyrosine ratio (BTR) <5, alani

125 ldup of branched-chain keto-acids (BCKA) and branched-chain amino acids (BCAA) in body fluids (e.g. k

126 duced muscle expression of genes involved in branched-chain amino acids (BCAA) metabolism.

127 are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, ther

128 orphology and higher levels of ketogenic and branched-chain amino acids (BCAA).

129 -1.kg-1.180 min; P = 0.04; eta2p = 0.31] and branched-chain amino acids (BCAAs) [between-group differ

130 esized that a greater decline in circulating branched-chain amino acids (BCAAs) after weight loss ind

131 Circulating branched-chain amino acids (BCAAs) and aromatic amino ac

132 Circulating amino acids, such as branched-chain amino acids (BCAAs) and aromatic amino ac

133 emonstrated, while it is yet unclear whether branched-chain amino acids (BCAAs) are a primary input o

134 We find that elevated plasma levels of branched-chain amino acids (BCAAs) are associated with a

135 tudies have shown that increased circulating branched-chain amino acids (BCAAs) are associated with i

136 Recent studies have shown that circulating branched-chain amino acids (BCAAs) are elevated in obese

137 Branched-chain amino acids (BCAAs) are three of the nine

138 The branched-chain amino acids (BCAAs) are vital to both gro

139 Circulating branched-chain amino acids (BCAAs) associate with insuli

140 the same initiating events, these tumors use branched-chain amino acids (BCAAs) differently.

141 The branched-chain amino acids (BCAAs) Ile, Val, and Leu are

142 demiological and experimental data implicate branched-chain amino acids (BCAAs) in the development of

143 The branched-chain amino acids (BCAAs) Leu, Ile, and Val are

144 Complete oxidation of the branched-chain amino acids (BCAAs) leucine, isoleucine (

145 The branched-chain amino acids (BCAAs) leucine, isoleucine,

146 Based on evidence that dysregulation of branched-chain amino acids (BCAAs) may contribute to the

147 Altered branched-chain amino acids (BCAAs) metabolism is a disti

148 bs (n = 24) were enterally supplemented with branched-chain amino acids (BCAAs), carbohydrate (maltod

149 Dietary supplementation with branched-chain amino acids (BCAAs), including leucine, i

150 that BCAT1, a cytosolic aminotransferase for branched-chain amino acids (BCAAs), is aberrantly activa

151 Branched-chain amino acids (BCAAs), particularly leucine

152 A preceded by reduced amino acid proline and branched-chain amino acids (BCAAs), respectively.

153 ed in the oxidation of fatty acids (FAs) and branched-chain amino acids (BCAAs), senses nutrients and

154 ccompanied by elevated circulating levels of branched-chain amino acids (BCAAs), whereas both paramet

155 g healthy mice a diet with reduced levels of branched-chain amino acids (BCAAs), which are associated

156 the enzyme that initiates the catabolism of branched-chain amino acids (BCAAs).

157 alpha-keto acids (BCKAs) are catabolites of branched-chain amino acids (BCAAs).

158 Branched-chain amino acids (BCAAs, i.e., valine, leucine

159 Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leu

160 Branched-chain amino acids (BCAAs; leucine, isoleucine a

161 r very-low-density lipoprotein measures, and branched-chain amino acids (e.g., leucine OR = 2.94, 2.5

162 erprints of severe obesity were aromatic and branched-chain amino acids (elevated), metabolites relat

163 4.1, 95% CI [-7.0; -1.1], p = 0.007) and the branched-chain amino acids (leucine: beta = -6.0, 95% CI

164 er biochemical inhibition of biosynthesis of branched-chain amino acids (precursors to branched-chain

165 posure to PFAS and increased serum levels of branched-chain amino acids (valine, leucine, and isoleuc

166 Changes in branched-chain amino acids after MI were associated with

167 Circulating branched-chain amino acids and aromatic amino acids were

168 e with low FENO, had higher levels of plasma branched-chain amino acids and bile acids.

169 tion, we prepared a series of 11 fluorinated branched-chain amino acids and evaluated them and their

170 to MS, we detected significant increases in branched-chain amino acids and intermediates of arginine

171 abolism, ETHE1 also affects the oxidation of branched-chain amino acids and lysine.

172 resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation

173 For example, branched-chain amino acids and proline, required for col

174 n family are involved in the biosynthesis of branched-chain amino acids and/or in the Met chain elong

175 e-dependent decarboxylating enzyme that uses branched-chain amino acids as substrate.

176 The metabolite 3-MOB along with related branched-chain amino acids demonstrated strong predictab

177 le genome-wide association studies (GWAS) on branched-chain amino acids have identified some regulato

178 lysis revealed a defect in the catabolism of branched-chain amino acids in bkdE1alpha Furthermore, th

179 und reduced concentrations of vitamin B6 and branched-chain amino acids in PSC (P < .0001), which str

180 genotype and diet, with a unique increase in branched-chain amino acids in the Glyco(Hi) HFD group.

181 hypothesis that raised plasma levels of the branched-chain amino acids isoleucine, leucine, and vali

182 The branched-chain amino acids leucine and isoleucine lower

183 icantly raised the circulating levels of the branched-chain amino acids leucine, isoleucine, and vali

184 influenced starch and sucrose, nitrogen, and branched-chain amino acids metabolism pathways.

185 talyses the transfer of the amino group from branched-chain amino acids to alpha-ketoglutarate (alpha

186 howed severe disturbance in the synthesis of branched-chain amino acids upon treatment with imazapyr.

187 We radiofluorinated selected branched-chain amino acids via the same radical fluorina

188 Prominent changes in branched-chain amino acids were observed after 1 week of

189 BCAT1 catalyzes the transamination of branched-chain amino acids while converting alpha-ketogl

190 alyses the first step in the biosynthesis of branched-chain amino acids(1).

191 holipids and amino acids (Trp, Met, and Cys, branched-chain amino acids), as well as carnitine shuttl

192 metabolic precursors (i.e., fatty acids and branched-chain amino acids), isotope labeling analyses s

193 istently higher content of free amino acids (branched-chain amino acids, alanine, serine, glycine, pr

194 and the catabolism of odd-chain fatty acids, branched-chain amino acids, and cholesterol.

195 -density lipoprotein lipids, glucose levels, branched-chain amino acids, and inflammatory markers.

196 luding diacylglycerols and triacylglycerols, branched-chain amino acids, and markers reflecting metab

197 The branched-chain amino acids, creatine, lysine, 2-aminobut

198 Neither essential amino acids, branched-chain amino acids, nor any individual amino aci

199 es of cardiovascular disease risk (including branched-chain amino acids, select unsaturated lipid spe

200 t-activity rhythm) and metabolic parameters (branched-chain amino acids, tryptophan pathway, phenylal

201 By altering the availability of branched-chain amino acids, we further demonstrated CodY

202 Metformin reduced levels of circulating branched-chain amino acids, which regulate tryptophan up

203 by AMP deaminase 3 (Ampd3) and catabolism of branched-chain amino acids.

204 nd enhanced levels of volatiles derived from branched-chain amino acids.

205 or activation and for feedback inhibition by branched-chain amino acids.

206 e availability of key nutrients like GTP and branched-chain amino acids.

207 , an essential enzyme in the biosynthesis of branched-chain amino acids.

208 s well as single-nucleotide polymorphisms in branched-chain amino-acid transaminase 1 (BCAT1) and phe

209 Branched-chained amino acids (BCAAs) (Leu, Ile, and Val)

210 Indeed, there is much promise that branched-chain aminoacids might provide a screening biom

211 ere we show that expression of the cytosolic branched chain aminotransferase (BCATc) is triggered by

212 Inhibitors of mitochondrial branched chain aminotransferase (BCATm), identified usin

213 Inhibitors of the mitochondrial branched chain aminotransferase may have therapeutic pot

214 series of potent inhibitors of mitochondrial branched-chain aminotransferase (BCATm) based on a 2-ben

215 We now analyzed branched-chain aminotransferase 6 (BCAT6).

216 rategy to two essential E. coli enzymes: the branched-chain aminotransferase BCAT and the DNA replica

217 Thr and protected the Arabidopsis plastidial branched-chain aminotransferase BCAT3 from inactivation

218 in tested alpha- and beta-proteobacteria, a branched-chain aminotransferase in tested cyanobacteria,

219 the Ser-derived enamine/imine inactivates a branched-chain aminotransferase; RidA prevents this dama

220 Branched-chain aminotransferases (BCAT) are enzymes that

221 Arabidopsis thaliana possesses six branched-chain aminotransferases (BCAT1-6).

222 emonstrating the important role of the three branched-chain aminotransferases in converting Met to it

223 Branched-chain ammonium salts showed lower affinity.

224 ide of the co-culture with notable levels of branched chain and sulphur-containing amino acids.

225 increased particle-particle repulsion due to branched chains and ligand polydispersity.

226 Circulating branched-chain and aromatic amino acids (alanine, glycin

227 Recent studies revealed strong evidence that branched-chain and aromatic amino acids (BCAAs and AAAs)

228 also present reduced intracellular levels of branched-chain and aromatic amino acids (BCAAs and ARO A

229 Previously reported markers, branched-chain and aromatic amino acids and glutamine/gl

230 The relative concentrations of branched-chain and aromatic amino acids significantly in

231 oprotein lipid subclasses and particle size, branched-chain and aromatic amino acids, and inflammatio

232 ide 1), glucose, and multiple AAs, including branched-chain and aromatic species, exhibited a more ra

233 naceous plants secrete acylsugars, which are branched-chain and straight-chain fatty acids esterified

234 dative stress: 1) ROS-induced auxotrophy for branched-chain, aromatic, and sulfurous amino acids; 2)

235 Fatty acid (FA) composition covered the branched chain C13ai to C22:5 n3 with variable content i

236 K29 linkages exist in cells within mixed or branched chains containing other linkages.

237 and stable mitochondrial complex I using the branched-chain detergent lauryl maltose neopentyl glycol

238 hate synthases (IDSs) produce the ubiquitous branched-chain diphosphates of different lengths that ar

239 Akin to their homotypic counterparts, branched chains elicit a wide array of biological output

240 ome preferred straight-chain elongation over branched-chain elongation.

241 Straight and branched-chain esters exhibited a distinct pattern.

242 sed under extremely low O(2) (0.5kPa), while branched-chain esters were not significantly affected in

243 PM had a higher content of saturated FA and branched-chain FA.

244 assay, host ACSLs were found to activate Ct branched-chain FAs, suggesting that one function of the

245 The branched chain fatty acid (BCFA) concentration (15 to 18

246 Abcd3-/- mice accumulated the branched chain fatty acid phytanic acid after phytol loa

247 ed normal fatty acids (n-MUFA) and saturated branched chain fatty acids (BCFA) are structurally chara

248 The mean intake (500 mg/day) of branched chain fatty acids (BCFA) in western countries i

249 Additionally, we show that levels of branched chain fatty acids in human cells are perturbed

250 es to arsenic are caused by variation in iso-branched chain fatty acids.

251 tly after hatching in response to monomethyl branched-chain fatty acid (mmBCFA) deficiency.

252 us titers that correlated with a decrease in branched-chain fatty acid biosynthesis.

253 ved from the phenylpropanoid pathway) with a branched-chain fatty acid by the catalysis of the putati

254 synthesis, the BCAAs serve as precursors for branched-chain fatty acids (BCFAs), which are predominan

255 ously showed that leucine-derived monomethyl branched-chain fatty acids (mmBCFAs) and derived glucosy

256 Here, we show that monomethyl branched-chain fatty acids (mmBCFAs) and their derivativ

257 be required for the synthesis of monomethyl branched-chain fatty acids (mmBCFAs) from BCAAs.

258 Odd and branched-chain fatty acids (OBCFA) are of interest, sinc

259 believed to be involved in the metabolism of branched-chain fatty acids and bile acid intermediates.

260 show that ABCD3 is involved in transport of branched-chain fatty acids and C27 bile acids into the p

261 except that they also contain chlamydia-made branched-chain fatty acids in the 2-position.

262 he proportion of starch in the sample, while branched-chain fatty acids were correlated to proteins c

263 oral and fruity odours while ethyl esters of branched-chain fatty acids were less associated with the

264 like very-long-chain fatty acids [VLCFAs] or branched-chain fatty acids) and lack of products (like b

265 of branched-chain amino acids (precursors to branched-chain fatty acids) by imazapyr showed concentra

266 porate straight-chain and bacterial specific branched-chain fatty acids.

267 cies composition consisting of saturated and branched-chain fatty acids.

268 us fruit is determined by the composition of branched-chain flavanone glycosides, the predominant fla

269 ia rebaudiana catalyzes the formation of the branched-chain glucoside that defines the stevia molecul

270 The activity and selectivity toward branched chains is markedly enhanced by the proteasomal

271 ed disorder caused by the dysfunction in the branched chain keto-acid dehydrogenase (BCKDH) enzyme.

272 es, mainly lactate, alpha-ketoglutarate, and branched chain keto-acids.

273 olomic analysis revealed increased levels of branched-chain keto acids (BCKA), and BCAA in plasma of

274 increased maximal capacity of respiration on branched-chain keto acids and fatty acids.

275 oduction in leukaemia cells by aminating the branched-chain keto acids.

276 Among the metabolites identified, the branched-chain keto-acid metabolite 3-methyl-2-oxovalera

277 This leads to buildup of branched-chain keto-acids (BCKA) and branched-chain amin

278 t LipL is essential to modify E2 subunits of branched chain ketoacid and pyruvate dehydrogenases duri

279 ects of branched-chain amino acid (BCAA) and branched-chain ketoacid (BCKA) ingestion on postprandial

280 Although deficiency of the branched-chain ketoacid dehydrogenase (BCKDC) and associ

281 t is deficient in the E1alpha subunit of the branched-chain ketoacid dehydrogenase (BCKDH) complex.

282 Intracellular BCKAs are cleared by branched-chain ketoacid dehydrogenase (BCKDH), which is

283 The regulation of the BCKDC by the branched-chain ketoacid dehydrogenase kinase has also be

284 ism genes, including those encoding putative branched-chain ketoacid dehydrogenase subunits, is highl

285 nase, alpha-ketoglutarate dehydrogenase, and branched-chain ketoacid dehydrogenase.

286 ) position of guanine, whereas repair of the branched-chain lesions relied on nucleotide excision rep

287 y incorporated the correct dCMP opposite the branched-chain lesions.

288 These species lead to the formation of a branched chain-like network rather than discrete structu

289 ockage effects elicited by the straight- and branched-chain O (6)-alkyl-dG lesions.

290 gation process resulting in the formation of branched chains of globular particles made of partially

291 itches on insulin exocytosis for glucose and branched-chain oxoacids as secretagogues (it does so par

292 higher rate of solute + water diffusion than branched-chain phospholipids, yet the former supported a

293 ring canalogenesis tip cells divide and form branched chains prior to vessel formation.

294 drolysis, and substrate ubiquitination, with branched chains providing maximal stimulation.

295 s is crucial considering evidence suggesting branched chains regulate the stability of proteins.

296 We used branched-chain RNA in situ hybridization to detect HHV-6

297 n Mass Spectrometry (UbiChEM-MS) to identify branched chains that cannot be detected using bottom-up

298 otes degradation of substrates modified with branched chains under multi-turnover conditions.

299 ed for a polymer model system of differently branched chain walking polyethylenes in five different s

300 found to preferentially flow in single-file, branched chains within the POCs.