ライフサイエンスコーパス: branched-chain

1 lysis indicates the presence of K48 in these branched chains.

2 as single chains and, to a lesser degree, as branched chains.

3 Interestingly, the E2 subunit of the branched chain 2-oxo acid dehydrogenase complex also rem

4 dehydrogenase complex, the E2 subunit of the branched chain 2-oxo acid dehydrogenase complex, the E2

5 er, the 2-oxoglutarate dehydrogenase (OGDH), branched-chain 2-oxoacid dehydrogenase (BCKDH), and pyru

6 hy dogs (P < 0.05) with the exception of the branched chain AA valine, which was elevated in diabetic

7 gensis metabolites, bile acids, and elevated branched chain AA).

8 rations of amino acids (AAs), in particular, branched chain AAs (BCAAs), are often found increased in

9 ytosis response is activated through reduced branched-chain AAs (leucine, isoleucine, valine).

10 In the case of branched-chain acids, the exchange is restricted to abou

11 Acyl CoA Oxidase 2 (ACOX2) encodes branched-chain acyl-CoA oxidase, a peroxisomal enzyme be

12 and even-alkyl chain alkylresorcinols (AR), branched-chain alkylresorcinols (bcAR) and methylalkylre

13 Branched chain alpha-keto acid dehydrogenase enzyme acti

14 enes virulence by using mutants deficient in branched-chain alpha-keto acid dehydrogenase (BKD), an e

15 horylated form of the E1alpha subunit of the branched-chain alpha-keto acid dehydrogenase complex (BC

16 or) to alter alkane Cn and expression of the branched-chain alpha-keto acid dehydrogenase complex and

17 pyruvate carboxykinase, aconitate hydratase, branched-chain alpha-keto acid dehydrogenase E1 componen

18 amino acid (BCAA) catabolism is regulated by branched-chain alpha-keto acid dehydrogenase, an enzyme

19 in (ybgE bcd ywaA) that is unable to convert branched-chain alpha-keto acids to ILV or to use ILV as

20 h catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids, is essentially devoid o

21 , encoding an activator of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) respo

22 Branched-chain alpha-ketoacid dehydrogenase (BCKDH) cata

23 The mitochondrial branched-chain alpha-ketoacid dehydrogenase complex (BCK

24 meostasis is controlled by the mitochondrial branched-chain alpha-ketoacid dehydrogenase complex (BCK

25 ase phosphatase (BDP) component of the human branched-chain alpha-ketoacid dehydrogenase complex (BCK

26 The purified mammalian branched-chain alpha-ketoacid dehydrogenase complex (BCK

27 ally, silencing the expression of a putative branched-chain alpha-ketoacid dehydrogenase E1 beta-subu

28 The branched-chain alpha-ketoacid dehydrogenase phosphatase

29 d an accumulation of metabolites upstream of branched-chain alpha-ketoacid oxidation, consistent with

30 REBP was rapidly inhibited when incubated in branched-chain alpha-ketoacids, saturated and unsaturate

31 le, photorespiration, and the degradation of branched-chain alpha-ketoacids.

32 s can be preserved through inhibition of the branched-chain-alpha-ketoacid dehydrogenase (BCKD) compl

33 y be assembled from two distinct moieties, a branched-chain amine that is acylated with a novel polyu

34 convergence of microRNAs and TFs within the branched chain amino acid (BCAA) metabolic pathway, poss

35 electrophoresis (MD-CE) assay for monitoring branched chain amino acid (BCAA) uptake/release dynamics

36 In addition, (1)H MRS showed an increase in branched chain amino acid and alanine concentrations.

37 acid metabolism were evident from increased branched chain amino acid and asparagine levels and alte

38 detection of the major CoA-intermediates of branched chain amino acid degradation in biological samp

39 oteins: the H-protein and the E2 subunits of branched chain amino acid dehydrogenase (BCDH) and alpha

40 e disease (MSUD) is an inherited disorder of branched chain amino acid metabolism presenting with neo

41 ained before and 7 hours after a single oral branched chain amino acid mixture enriched with leucine

42 Branched chain amino acid supplements may be of value in

43 th microbial function; 13 pathways including branched chain amino acid synthesis were significantly e

44 lude testosterone analogues, growth hormone, branched chain amino acid, glutamine, arginine, creatine

45 Lung tumors catabolize circulating branched chain amino acids (BCAA) to extract nitrogen fo

46 rsity includes: inflammation, degradation of branched chain amino acids (BCAA), and regulation of per

47 ith varying doses of leucine or a mixture of branched chain amino acids (BCAAs) on myofibrillar prote

48 High-protein diets, rich in methionine and branched chain amino acids (BCAAs), apparently reduce li

49 reductions were seen in the concentration of branched chain amino acids (BCAAs), which are key precur

50 tissue can metabolize substantial amounts of branched chain amino acids (BCAAs).

51 insulin were to reduce plasma levels of the branched chain amino acids (BCAs) leucine/isoleucine and

52 reased in presymptomatic HD sheep, including branched chain amino acids (isoleucine, leucine and vali

53 r metabolite biomarkers of diabetes, such as branched chain amino acids and aromatic amino acids, sug

54 S. aureus CodY was activated in vitro by the branched chain amino acids and GTP, CodY appears to link

55 t differences in the amounts of aromatic and branched chain amino acids between the groups as well as

56 2 skeletal muscle had increased oxidation of branched chain amino acids but decreased oxidation of fa

57 ylase, and 3-methylcrotonyl-CoA carboxylase (branched chain amino acids catabolism).

58 The branched chain amino acids leucine, isoleucine, valine,

59 F1F0-ATPase system, fatty acid biosynthesis, branched chain amino acids metabolism), and molecular ch

60 Ceramides, lysolipids, aromatic amino acids, branched chain amino acids, and stress-induced amino aci

61 ficits in enzymes required for catabolism of branched chain amino acids, ketones, and lactate, along

62 ase in acetate, lactate, succinate, alanine, branched chain amino acids, trimethylamine and a progres

63 coneogenesis and oxidations of glutamine and branched chain amino acids, which together sustain the n

64 lycolysis/gluconeogenesis, and metabolism of branched chain amino acids.

65 so decreased the expression of mitochondrial branched chain amino transferase (BCAT) which produces K

66 abolic disorder, affecting the metabolism of branched chain amino-acids (Valine, Leukine, Isoleukine)

67 ed esters arising from partial catabolism of branched chain amino-acids.

68 CodY is a branched-chain amino acid (BCAA) and GTP sensor and a gl

69 synthase (AHAS) catalyzes the first step of branched-chain amino acid (BCAA) biosynthesis, a pathway

70 cetohydroxyacid synthase (AHAS) required for branched-chain amino acid (BCAA) biosynthesis.

71 e (BCKDH) catalyzes the critical step in the branched-chain amino acid (BCAA) catabolic pathway and h

72 We previously described abnormalities in the branched-chain amino acid (BCAA) catabolic pathway as a

73 Branched-chain amino acid (BCAA) catabolism is regulated

74 augment BCKDC flux have been shown to reduce branched-chain amino acid (BCAA) concentrations in vivo.

75 enylbutyrate administration decreases plasma branched-chain amino acid (BCAA) concentrations, and pre

76 Branched-chain amino acid (BCAA) metabolism plays a cent

77 ncies and growth restriction associated with branched-chain amino acid accumulation and (ii) energy d

78 assic maple syrup urine disease pups reduced branched-chain amino acid accumulation in milk as well a

79 (E. coli aspartate aminotransferase, E. coli branched-chain amino acid aminotransferase, and Bacillus

80 and proteins, including ones in pathways of branched-chain amino acid and fatty acid metabolism and

81 Here, we highlight collaboration in branched-chain amino acid and pantothenate (vitamin B5)

82 olutionary age analysis revealed that, while branched-chain amino acid and proline catabolism are ver

83 and raised the root and shoot levels of the branched-chain amino acid biosynthesis intermediate 2-ox

84 . 2.2.1.6), which is the first enzyme in the branched-chain amino acid biosynthesis pathway.

85 cid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway.

86 ctively catalyze the first committed step of branched-chain amino acid biosynthesis, but ilvG is uniq

87 pA have been shown to regulate expression of branched-chain amino acid biosynthetic genes, suggesting

88 by metformin exposure, including changes in branched-chain amino acid catabolism and cuticle mainten

89 hat several Arabidopsis mutants deficient in branched-chain amino acid catabolism or fatty acid metab

90 It also increases our knowledge of the role branched-chain amino acid catabolism plays in seed devel

91 Increased plasma branched-chain amino acid concentrations are associated

92 the identification and characterization of a branched-chain amino acid decarboxylase, which would app

93 rior to this study, the relationship between branched-chain amino acid degradation (named for leucine

94 Furthermore, the Hadza GM is equipped for branched-chain amino acid degradation and aromatic amino

95 The branched-chain amino acid leucine is an essential nutrie

96 Adiponectin corrected the altered branched-chain amino acid metabolism caused by HFD and c

97 e disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with lif

98 zed the condensation of two intermediates in branched-chain amino acid metabolism, isovaleryl-Coenzym

99 tion of proteins in fatty acid oxidation and branched-chain amino acid metabolism.

100 e A (CoA) transfer to isoleucine and reduced branched-chain amino acid metabolism.

101 of the BCKDC, promotes metabolon formation, branched-chain amino acid oxidation, and cycling of nitr

102 ehydrogenase (PDH) as well as fatty acid and branched-chain amino acid oxidation.

103 IDH1 mutation and decreased activity of the branched-chain amino acid transaminase 1 (BCAT1) enzyme.

104 how that glioblastoma express high levels of branched-chain amino acid transaminase 1 (BCAT1), the en

105 on of its direct targets including the BCAT2 branched-chain amino acid transaminase 2) gene.

106 n with a chromosomal interval containing two branched-chain amino acid transferases, BCAT1 and BCAT2.

107 of the leucine, isoleucine, and valine (LIV) branched-chain amino acid transport system, reduced the

108 Despite each LIV protein being required for branched-chain amino acid transport, only the LivJ and L

109 Reduced branched-chain amino acid uptake and increased accumulat

110 etic performance in this group are creatine, branched-chain amino acid, and beta-hydryoxy-beta-methyl

111 thesized that protein, essential amino acid, branched-chain amino acid, and leucine intakes are assoc

112 ave been the subject of great scrutiny, as a branched-chain amino acid, Leu can be catabolized within

113 Leucine (Leu) is an essential branched-chain amino acid, which activates the mammalian

114 CodY is a branched-chain amino acid-responsive transcriptional reg

115 sted the effects of a genetic determinant of branched-chain amino acid/aromatic amino acid ratio on c

116 We genotyped the branched-chain amino acid/aromatic amino acid ratio-asso

117 Individuals carrying the C allele of the branched-chain amino acid/aromatic amino acid ratio-asso

118 ultivariate analyses identified preoperative branched-chain amino acid/tyrosine ratio (BTR) <5, alani

119 its and enzymes involved in the oxidation of branched-chain amino acids (BCAA) and fatty acids (e.g.,

120 The branched-chain amino acids (BCAA) are essential amino ac

121 ldup of branched-chain keto-acids (BCKA) and branched-chain amino acids (BCAA) in body fluids (e.g. k

122 een associated with a selective reduction in branched-chain amino acids (BCAA) in spite of adequate d

123 duced muscle expression of genes involved in branched-chain amino acids (BCAA) metabolism.

124 are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, ther

125 orphology and higher levels of ketogenic and branched-chain amino acids (BCAA).

126 esized that a greater decline in circulating branched-chain amino acids (BCAAs) after weight loss ind

127 Circulating branched-chain amino acids (BCAAs) and aromatic amino ac

128 Circulating amino acids, such as branched-chain amino acids (BCAAs) and aromatic amino ac

129 We find that elevated plasma levels of branched-chain amino acids (BCAAs) are associated with a

130 Branched-chain amino acids (BCAAs) are synthesized in pl

131 Branched-chain amino acids (BCAAs) are three of the nine

132 The branched-chain amino acids (BCAAs) are vital to both gro

133 mportant for acid adaptation, as turnover of branched-chain amino acids (bcAAs) could provide importa

134 the same initiating events, these tumors use branched-chain amino acids (BCAAs) differently.

135 The branched-chain amino acids (BCAAs) Ile, Val, and Leu are

136 demiological and experimental data implicate branched-chain amino acids (BCAAs) in the development of

137 the pools of specific metabolites, i.e., the branched-chain amino acids (BCAAs) isoleucine, leucine,

138 The branched-chain amino acids (BCAAs) Leu, Ile, and Val are

139 Complete oxidation of the branched-chain amino acids (BCAAs) leucine, isoleucine (

140 The branched-chain amino acids (BCAAs) leucine, isoleucine,

141 The branched-chain amino acids (BCAAs) valine, leucine and i

142 Therefore, the branched-chain amino acids (BCAAs), especially leucine,

143 Dietary supplementation with branched-chain amino acids (BCAAs), including leucine, i

144 that BCAT1, a cytosolic aminotransferase for branched-chain amino acids (BCAAs), is aberrantly activa

145 Branched-chain amino acids (BCAAs), particularly leucine

146 ed in the oxidation of fatty acids (FAs) and branched-chain amino acids (BCAAs), senses nutrients and

147 g healthy mice a diet with reduced levels of branched-chain amino acids (BCAAs), which are associated

148 the enzyme that initiates the catabolism of branched-chain amino acids (BCAAs).

149 Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leu

150 Branched-chain amino acids (BCAAs; leucine, isoleucine a

151 r very-low-density lipoprotein measures, and branched-chain amino acids (e.g., leucine OR = 2.94, 2.5

152 erprints of severe obesity were aromatic and branched-chain amino acids (elevated), metabolites relat

153 l transcriptional regulator that responds to branched-chain amino acids (isoleucine, leucine, and val

154 Genes for the synthesis of branched-chain amino acids (valine, isoleucine and leuci

155 Changes in branched-chain amino acids after MI were associated with

156 cumulation as well as circulating cytokines, branched-chain amino acids and acylcarnitines in the pat

157 Circulating branched-chain amino acids and aromatic amino acids were

158 e with low FENO, had higher levels of plasma branched-chain amino acids and bile acids.

159 to MS, we detected significant increases in branched-chain amino acids and intermediates of arginine

160 abolism, ETHE1 also affects the oxidation of branched-chain amino acids and lysine.

161 resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation

162 Binding studies with branched-chain amino acids and their analogs revealed th

163 n family are involved in the biosynthesis of branched-chain amino acids and/or in the Met chain elong

164 e-dependent decarboxylating enzyme that uses branched-chain amino acids as substrate.

165 ed a significant difference in the levels of branched-chain amino acids between the wild type and Del

166 amino acids for colonization, acquisition of branched-chain amino acids does not appear to be a deter

167 tend beyond a role for binding and acquiring branched-chain amino acids during commensalism.

168 sted that Ca. C. thermophilum may synthesize branched-chain amino acids from an intermediate(s) of th

169 le genome-wide association studies (GWAS) on branched-chain amino acids have identified some regulato

170 confirm an important role for catabolism of branched-chain amino acids in T2D and IFG.

171 to GTP in vitro but also responded poorly to branched-chain amino acids in vitro unless GTP was simul

172 atable by GTP but to a much lesser extent by branched-chain amino acids in vitro.

173 hypothesis that raised plasma levels of the branched-chain amino acids isoleucine, leucine, and vali

174 Branched-chain amino acids L-isoleucine, L-leucine, and

175 The branched-chain amino acids leucine and isoleucine lower

176 icantly raised the circulating levels of the branched-chain amino acids leucine, isoleucine, and vali

177 Branched-chain amino acids supplement may be helpful in

178 talyses the transfer of the amino group from branched-chain amino acids to alpha-ketoglutarate (alpha

179 howed severe disturbance in the synthesis of branched-chain amino acids upon treatment with imazapyr.

180 Accumulation of the branched-chain amino acids was accompanied by a 24-fold

181 Prominent changes in branched-chain amino acids were observed after 1 week of

182 BCAT1 catalyzes the transamination of branched-chain amino acids while converting alpha-ketogl

183 metabolic precursors (i.e., fatty acids and branched-chain amino acids), isotope labeling analyses s

184 istently higher content of free amino acids (branched-chain amino acids, alanine, serine, glycine, pr

185 and the catabolism of odd-chain fatty acids, branched-chain amino acids, and cholesterol.

186 -density lipoprotein lipids, glucose levels, branched-chain amino acids, and inflammatory markers.

187 luding diacylglycerols and triacylglycerols, branched-chain amino acids, and markers reflecting metab

188 nvolved with biosynthesis and degradation of branched-chain amino acids, as well as in the production

189 Neither essential amino acids, branched-chain amino acids, nor any individual amino aci

190 ociated with multiple metabolites, including branched-chain amino acids, other hydrophobic amino acid

191 es of cardiovascular disease risk (including branched-chain amino acids, select unsaturated lipid spe

192 Branched-chain amino acids, such as leucine and glucose,

193 g to the intracellular levels of GTP and the branched-chain amino acids, was previously shown to be a

194 of CodY with various levels of activation by branched-chain amino acids, we concluded that unliganded

195 By altering the availability of branched-chain amino acids, we further demonstrated CodY

196 nd enhanced levels of volatiles derived from branched-chain amino acids.

197 by AMP deaminase 3 (Ampd3) and catabolism of branched-chain amino acids.

198 lag in growth when nutritionally limited for branched-chain amino acids.

199 tin, C-reactive protein, acylcarnitines, and branched-chain amino acids.

200 protein, E1alpha phosphorylation, and plasma branched-chain amino acids.

201 anscriptional regulator that is activated by branched-chain amino acids.

202 known as yhdG) that encodes a transporter of branched-chain amino acids.

203 s well as single-nucleotide polymorphisms in branched-chain amino-acid transaminase 1 (BCAT1) and phe

204 SBPs, which had been previously annotated as branched-chain amino-acid-binding proteins.

205 Branched-chained amino acids (BCAAs) (Leu, Ile, and Val)

206 Indeed, there is much promise that branched-chain aminoacids might provide a screening biom

207 ere we show that expression of the cytosolic branched chain aminotransferase (BCATc) is triggered by

208 Inhibitors of mitochondrial branched chain aminotransferase (BCATm), identified usin

209 Inhibitors of the mitochondrial branched chain aminotransferase may have therapeutic pot

210 series of potent inhibitors of mitochondrial branched-chain aminotransferase (BCATm) based on a 2-ben

211 We now analyzed branched-chain aminotransferase 6 (BCAT6).

212 rategy to two essential E. coli enzymes: the branched-chain aminotransferase BCAT and the DNA replica

213 Thr and protected the Arabidopsis plastidial branched-chain aminotransferase BCAT3 from inactivation

214 in tested alpha- and beta-proteobacteria, a branched-chain aminotransferase in tested cyanobacteria,

215 Mitochondrial BCATm (branched-chain aminotransferase) catalyzes reversible tr

216 the Ser-derived enamine/imine inactivates a branched-chain aminotransferase; RidA prevents this dama

217 Branched-chain aminotransferases (BCAT) are enzymes that

218 The interface of BCAA metabolism lies with branched-chain aminotransferases (BCAT) that catalyze bo

219 Arabidopsis thaliana possesses six branched-chain aminotransferases (BCAT1-6).

220 onality of human mitochondrial and cytosolic branched-chain aminotransferases (hBCATm and hBCATc, res

221 emonstrating the important role of the three branched-chain aminotransferases in converting Met to it

222 ed amino acid flux and charging of tRNAs for branched chain and aromatic amino acids (e.g. leucine an

223 Circulating branched-chain and aromatic amino acids (alanine, glycin

224 Recent studies revealed strong evidence that branched-chain and aromatic amino acids (BCAAs and AAAs)

225 also present reduced intracellular levels of branched-chain and aromatic amino acids (BCAAs and ARO A

226 Previously reported markers, branched-chain and aromatic amino acids and glutamine/gl

227 Five branched-chain and aromatic amino acids had highly signi

228 The relative concentrations of branched-chain and aromatic amino acids significantly in

229 oprotein lipid subclasses and particle size, branched-chain and aromatic amino acids, and inflammatio

230 Branched-chain and aromatic amino acids, gluconeogenesis

231 ide 1), glucose, and multiple AAs, including branched-chain and aromatic species, exhibited a more ra

232 In conclusion, the levels of branched-chain, aromatic amino acids and alanine increas

233 Fatty acid (FA) composition covered the branched chain C13ai to C22:5 n3 with variable content i

234 K29 linkages exist in cells within mixed or branched chains containing other linkages.

235 and stable mitochondrial complex I using the branched-chain detergent lauryl maltose neopentyl glycol

236 hate synthases (IDSs) produce the ubiquitous branched-chain diphosphates of different lengths that ar

237 immunoassay were tested for HCV viremia by a branched-chain DNA assay.

238 being consistently reported with the Siemens branched-chain DNA assay.

239 Straight and branched-chain esters exhibited a distinct pattern.

240 sed under extremely low O(2) (0.5kPa), while branched-chain esters were not significantly affected in

241 We analyzed how the activity of ACS-1 on branched chain FA C17ISO impacts maternal lipid content,

242 PM had a higher content of saturated FA and branched-chain FA.

243 This study shows a novel role of branched chain FAs whose functions in humans and animals

244 eria monocytogenes contains mostly saturated branched-chain FAs (BCFAs), which support growth at low

245 assay, host ACSLs were found to activate Ct branched-chain FAs, suggesting that one function of the

246 describe how the particular combination of a branched chain fatty acid and an acyl-CoA synthetase is

247 Abcd3-/- mice accumulated the branched chain fatty acid phytanic acid after phytol loa

248 tly after hatching in response to monomethyl branched-chain fatty acid (mmBCFA) deficiency.

249 us titers that correlated with a decrease in branched-chain fatty acid biosynthesis.

250 ved from the phenylpropanoid pathway) with a branched-chain fatty acid by the catalysis of the putati

251 ld induction of the bkd operon (required for branched-chain fatty acid synthesis) and 6-fold hyperrep

252 cids to ILV or to use ILV as a precursor for branched-chain fatty acid synthesis.

253 Anteiso-branched-chain fatty acids (BCFA) represent the dominant

254 ribute to growth of L. monocytogenes include branched-chain fatty acids (BCFAs), amino acids, and oth

255 synthesis, the BCAAs serve as precursors for branched-chain fatty acids (BCFAs), which are predominan

256 ously showed that leucine-derived monomethyl branched-chain fatty acids (mmBCFAs) and derived glucosy

257 Here, we show that monomethyl branched-chain fatty acids (mmBCFAs) and their derivativ

258 be required for the synthesis of monomethyl branched-chain fatty acids (mmBCFAs) from BCAAs.

259 Odd and branched-chain fatty acids (OBCFA) are of interest, sinc

260 believed to be involved in the metabolism of branched-chain fatty acids and bile acid intermediates.

261 show that ABCD3 is involved in transport of branched-chain fatty acids and C27 bile acids into the p

262 except that they also contain chlamydia-made branched-chain fatty acids in the 2-position.

263 Supplementing rich medium with short, branched-chain fatty acids or derepressing expression of

264 he proportion of starch in the sample, while branched-chain fatty acids were correlated to proteins c

265 oral and fruity odours while ethyl esters of branched-chain fatty acids were less associated with the

266 like very-long-chain fatty acids [VLCFAs] or branched-chain fatty acids) and lack of products (like b

267 cies composition consisting of saturated and branched-chain fatty acids.

268 porate straight-chain and bacterial specific branched-chain fatty acids.

269 amino acids, as well as in the production of branched-chain fatty acids.

270 ntracellular production of the precursors of branched-chain fatty acids.

271 the synthesis of isovaleryl-HSL (IV-HSL), a branched-chain fatty acyl-HSL.

272 us fruit is determined by the composition of branched-chain flavanone glycosides, the predominant fla

273 ed disorder caused by the dysfunction in the branched chain keto-acid dehydrogenase (BCKDH) enzyme.

274 es, mainly lactate, alpha-ketoglutarate, and branched chain keto-acids.

275 H-like" enzyme and provide evidence that the branched-chain keto acid dehydrogenase (BCKDH) complex i

276 in the forward (BCAA synthesis) and reverse (branched-chain keto acid synthesis) reactions.

277 olomic analysis revealed increased levels of branched-chain keto acids (BCKA), and BCAA in plasma of

278 Branched-chain keto acids (BCKAs) are associated with in

279 increased maximal capacity of respiration on branched-chain keto acids and fatty acids.

280 acids (BCAAs) are synthesized in plants from branched-chain keto acids, but their metabolism is not c

281 oduction in leukaemia cells by aminating the branched-chain keto acids.

282 Among the metabolites identified, the branched-chain keto-acid metabolite 3-methyl-2-oxovalera

283 This leads to buildup of branched-chain keto-acids (BCKA) and branched-chain amin

284 ed inactivating mutations in the gene BCKDK (Branched Chain Ketoacid Dehydrogenase Kinase) in consang

285 rough Krebs cycle disruption associated with branched-chain ketoacid accumulation.

286 Although deficiency of the branched-chain ketoacid dehydrogenase (BCKDC) and associ

287 iated inactivation of the E1alpha subunit of branched-chain ketoacid dehydrogenase (BCKDH).

288 The regulation of the BCKDC by the branched-chain ketoacid dehydrogenase kinase has also be

289 ism genes, including those encoding putative branched-chain ketoacid dehydrogenase subunits, is highl

290 nase, alpha-ketoglutarate dehydrogenase, and branched-chain ketoacid dehydrogenase.

291 These species lead to the formation of a branched chain-like network rather than discrete structu

292 ects are driven by duplications in the BCMA (branched-chain methionine allocation) loci controlling t

293 Notably, branched-chain or neopentyl glycol maltoside detergents

294 higher rate of solute + water diffusion than branched-chain phospholipids, yet the former supported a

295 en initiate AB dehydropolymerization to form branched-chain polyaminoborane polymers.

296 ring canalogenesis tip cells divide and form branched chains prior to vessel formation.

297 drolysis, and substrate ubiquitination, with branched chains providing maximal stimulation.

298 s is crucial considering evidence suggesting branched chains regulate the stability of proteins.

299 be a substrate-promiscuous enzyme catalyzing branched-chain rhamnosylation of flavonoids glucosylated

300 n Mass Spectrometry (UbiChEM-MS) to identify branched chains that cannot be detected using bottom-up