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1 very large extended family whose members had branchial and hearing anomalies associated with commissu
2 haracterized by hearing loss with associated branchial and renal anomalies.
3  To gain insight into the factors that guide branchial aortic arch development, we examined the proce
4                   In wild type embryos, each branchial aortic arch first appears as an island of angi
5 rders associated with the development of the branchial apparatus, and disorders associated with auton
6 suggested to control patterning of the first branchial arch (BA1) and odontogenesis.
7                        In mammals, the first branchial arch (BA1) develops into a number of craniofac
8 yclopia, as well as alterations in the first branchial arch (BA1) leading to lack of jaw (agnathia).
9 he mandible, which is derived from the first branchial arch (BA1).
10 gnaling and gene expression within the first branchial arch (BA1).
11 heir nested expression patterns in the first branchial arch (primordium for jaw) and mutant phenotype
12  the rhombomere 4 (r4) migratory stream into branchial arch 2 (ba2), is due to chemoattraction throug
13 ssion in the mandibular portion of the first branchial arch and central nervous system.
14 t birth and display holoprosencephaly, first branchial arch and eye defects.
15 in the kidney and repression by Hoxa2 in the branchial arch and facial mesenchyme in vivo.
16 the developing mammalian kidney and Hoxa2 in branchial arch and facial mesenchyme.
17 ts including cleft face (involving the first branchial arch and frontonasal processes), incomplete he
18                                        First branchial arch and heart tissue from E10.5 embryos were
19 ral crest cells that migrate into the second branchial arch and is essential for proper patterning of
20 within the mandibular component of the first branchial arch and later in the primordia of middle ear-
21                   Most notably, during first branchial arch and limb development, both YY1 and Msx2 w
22 tant mice show underdevelopment of the first branchial arch and midline fusion defects.
23 strict neural crest expression to the second branchial arch and more posterior regions.
24           Inactivation of Bmp4 in the caudal branchial arch and splanchnic mesoderm and OFT myocardiu
25 presumptive secondary heart field within the branchial arch and splanchnic mesoderm that contributes
26 sumptive secondary heart field, derived from branchial arch and splanchnic mesoderm, patterns the for
27 es and of the maxillary process of the first branchial arch are integral to lip and primary palate de
28  aorta, as well as variable narrowing of the branchial arch arteries and proximal dorsal aorta.
29 ilure to establish the initial complement of branchial arch arteries in the caudal pharyngeal region.
30 -31, shows that the initial formation of the branchial arch arteries is not disturbed in ETA-/- or EC
31 cts that includes abnormal patterning of the branchial arch arteries, double-outlet right ventricle,
32 rentiation of smooth muscle cells within the branchial arch arteries, which are derived from the neur
33 derm near the junction of the aortic sac and branchial arch arteries.
34 chymal cells of the distal outflow tract and branchial arch arteries.
35 ferentiation markers in the dorsal aorta and branchial arch arteries.
36 n mice impairs asymmetric remodelling of the branchial arch artery (BAA) system, resulting in randomi
37 n the CNC resulted in enlarged, hemorrhaging branchial arch blood vessels and hydrocephalus.
38 y fail to form neurons in cranial ganglia or branchial arch cartilage, illustrating that they are at
39 s, including cornea, trigeminal ganglion and branchial arch cartilage.
40        In addition, the migratory ability of branchial arch cells from normal explants could be reduc
41 of Ph/Ph cells to PDGF-A treatment of normal branchial arch cells in vitro with recombinant PDGF-AA s
42                       Pitx2 was expressed in branchial arch core mesoderm and both Pitx2 null and Pit
43 ntal disorder characterized by hearing loss, branchial arch defects, and renal anomalies.
44 disorder characterized by the association of branchial arch defects, hearing loss, and renal anomalie
45 , including external ear anomalies, abnormal branchial arch derivatives, heart malformations, diaphra
46  hindbrain and for the formation of adjacent branchial arch derivatives.
47 patterning and the subsequent development of branchial arch derivatives.
48 ssing their differentiation, while a further branchial arch derived signal, namely Bmp7, is an overal
49          Moreover, we identified Fgf8 as the branchial arch derived signal.
50  In mouse embryos, mutation of Prdm1 affects branchial arch development and leads to persistent trunc
51  To determine the potential role of dHAND in branchial arch development and to assess the role of the
52 1 reveals that it is essential for posterior branchial arch development, although the mandibular arch
53 g analysis of the potential role of dHAND in branchial arch development.
54 or HAND2 is required during limb, heart, and branchial arch development.
55 aniofacial cartilage deposition and impaired branchial arch development.
56 ted in cardiac hypoplasia but with preserved branchial arch development.
57 elates with a delay in expression of Fgf8 in branchial arch ectoderm and a failure of neural crest ce
58 egulated by an interplay between a specified branchial arch ectoderm and a plastic mesenchyme.
59         Zebrafish foxi1 is also expressed in branchial arch ectoderm and endoderm, and morpholino kno
60  Endothelin-1 (ET-1) signaling regulates the branchial arch enhancer and is required for dHAND expres
61                       Mice lacking the dHAND branchial arch enhancer died perinatally and exhibited a
62 cells stop and collapse filopodia at the 2nd branchial arch entrances, but do not die.
63  odontogenesis, which are not found in other branchial arch epithelia.
64               Sema3A mRNA is concentrated in branchial arch epithelium at the appropriate time to med
65                            In addition, some branchial arch explants and untransfected COS7 cells rep
66 ealed that geniculate axons were repelled by branchial arch explants that were previously shown to be
67 mesenchymal cells, cell migration from Ph/Ph branchial arch explants was compared to migration from n
68 e Hand2 allele or deleting the ventrolateral branchial arch expression of Hand2 led to a novel phenot
69 eodomain binding sites that are required for branchial arch expression.
70  comparing protein binding to these sites in branchial arch extracts from endothelin receptor A (Ednr
71                    Crest cells of the second branchial arch generate few facial ganglion neurons and
72  there is a tight link between the resulting branchial arch Hox code and a particular skeletal morpho
73  resulting in the persistence of an abnormal branchial arch Hox code and extensive defects in the hyo
74 sulting in the reestablishment of the normal branchial arch Hox code.
75 ne for these facial prominences in the first branchial arch in mice.
76 rtage of the CNC contribution into the first branchial arch in the Lef1 mutant.
77   Overexpression of Hoxa2 in the chick first branchial arch leads to a transformation of first arch c
78             Proliferation was reduced in the branchial arch mesenchyme of Yap and Taz CNC conditional
79                                  Explants of branchial arch mesenchyme were strongly growth-promoting
80 c sac mesothelium and in left splanchnic and branchial arch mesoderm near the junction of the aortic
81 ic progression in the first, but not second, branchial arch mesoderm.
82 nomous function in expansion and survival of branchial arch mesoderm.
83 re the lateral rectus and the proximal first branchial arch muscle primordia arise.
84 ted to the lateral rectus and proximal first branchial arch muscles; many also contributed to the dor
85 ing has been implicated in somite, limb, and branchial arch myogenesis but the mechanisms and roles a
86 culating disc of temporomandibular joint and branchial arch nerve ganglia.
87               dHAND is also expressed in the branchial arch neural crest, which contributes to cranio
88 eral neural crest sublineages, including the branchial arch neural crest.
89                         The diminutive first branchial arch of mutants could not be explained by loss
90 the outgrowth and orientation effects of the branchial arch on motor axons.
91 mus alters Hoxa2 expression and consequently branchial arch patterning, demonstrating that neural cre
92  reduction in head size after 1 day, loss of branchial arch structures after 2 days, and embryos with
93      Shh null mice have cyclopia and loss of branchial arch structures.
94 s from adjoining rhombomeres within a single branchial arch support the notion that the pattern of hi
95 a from both human fetal ear and mouse second branchial arch tissue confirmed that genes located among
96                                              Branchial arch tissue may thus act as a target-derived f
97               Muscles derived from the first branchial arch were absent, whereas muscles derived from
98 ent, whereas muscles derived from the second branchial arch were merely distorted in Pitx2 mutants at
99 ll-derived skeletal structures of the second branchial arch were morphologically transformed into ele
100 ived from craniofacial mesenchyme, the first branchial arch, and the limb bud.
101 res 4 and 5, the selective loss of the 2(nd) branchial arch, and the loss of most, but not all, 2(nd)
102  and the mandible bone derive from the first branchial arch, and their development depends upon the c
103 t signaling in the epaxial somite and second branchial arch, but not in the limb or the first branchi
104 , including the lateral neural folds, caudal branchial arch, hindbrain, and optic cup.
105  and defects in the derivatives of the first branchial arch, including cleft palate, suggesting a pro
106 llary and mandibular components of the first branchial arch, nasal processes, eyelid, midbrain, medul
107  shown to function as brain, olfactory bulb, branchial arch, otic vesicle and fin enhancers, recapitu
108 showed comparable expression patterns in the branchial arch, otic vesicle, forebrain and/or limb at e
109 -less gene family, is expressed in the first branchial arch, prior to the initiation of tooth develop
110 n factors required to initiate myogenesis in branchial arch- and somite-derived muscles are known, bu
111 ET-1/ECE-1/ETA pathway results in defects in branchial arch- derived craniofacial tissues, as well as
112 s of neural crest-derived tissues, including branchial arch-derived craniofacial structures, aortic a
113 utant mice are not viable and display severe branchial arch-derived facial skeleton defects, includin
114 mesoderm of the second heart field (SHF) and branchial arch-derived head muscles.
115 stablishing a baseline molecular bauplan for branchial arch-derived jaw development and further valid
116 ch, and the loss of most, but not all, 2(nd) branchial arch-derived tissues.
117 ocyte Growth Factor, although a component of branchial arch-mediated growth promotion and chemoattrac
118             A specific deletion of the Hand2 branchial arch-specific enhancer also leads to a hypopla
119 s in the branchial arches, and we identify a branchial arch-specific enhancer in the Dlx5/6 locus, wh
120 and proximal/distal domains within the first branchial arch.
121 NC cells in the proximal domain of the first branchial arch.
122 Tcf21, and Msc in the first, but not second, branchial arch.
123 ade the branchial arches, especially the 2nd branchial arch.
124 itx2 mutant descendents moved into the first branchial arch.
125 y pit, and mandibular component of the first branchial arch.
126 n, even when grafted directly into the first branchial arch.
127  the same spatial location within the fourth branchial arch.
128 arise in soft tissues derived from the first branchial arch.
129 eveloping anterior pituitary gland and first branchial arch.
130  a specific rhombomere and its corresponding branchial arch.
131 icles, the pharyngeal endoderm and the first branchial arch.
132  neural crest cells migrating into the third branchial arch.
133  but not mesenchymal expression in the first branchial arch.
134 oid arch take on the properties of the first branchial arch.
135 chial arch, but not in the limb or the first branchial arch.
136 ut not in the maxillary process of the first branchial arch.
137 mb bud or maintenance in the first or second branchial arch.
138 nto a distal-to-proximal invasion of the 2nd branchial arch.
139 downstream genes in each domain of the first branchial arch.
140 allele resulted in abnormal morphogenesis of branchial-arch arteries (BAAs) and defective OFT septati
141 ent, and Bmp4 expression was expanded in the branchial-arch ectoderm.
142 ecule is expressed in ventral splanchnic and branchial-arch mesoderm and outflow-tract (OFT) myocardi
143            Although the initial formation of branchial arches (BAs) is normal, expression of several
144 signals in the vicinity of the hindbrain and branchial arches act on migrating myogenic cells to infl
145 gh muscles derived from the first and second branchial arches also share a clonal relationship with d
146  expression in epaxial and hypaxial somites, branchial arches and central nervous system, and argued
147 in the ectodermal surfaces of the limb buds, branchial arches and epidermal appendages, which are all
148 narily distinct structures, for example, the branchial arches and eyes, respectively.
149 radation-1-like gene, expressed in embryonic branchial arches and in the conotruncus, appears to play
150 embryos, Ntan1 was strongly expressed in the branchial arches and in the tail and limb buds.
151 bryos, the Ubr1 expression is highest in the branchial arches and in the tail and limb buds.
152 erted from their migration pathways into the branchial arches and instead migrated around the otic ve
153 ression disrupts morphogenesis of the caudal branchial arches and leads to a failure to correctly ela
154 red for growth and development of the heart, branchial arches and limb buds.
155 e skeletal muscle precursors of the myotome, branchial arches and limbs as well as in the developing
156 pressed in midgestation mouse embryos in the branchial arches and limbs, consistent with the human ph
157 des paraxial presomitic mesoderm, notochord, branchial arches and neural crest derivatives.
158 f slow muscle, the photoreceptor cell layer, branchial arches and pectoral fins.
159 rk sheds light on the homology of vertebrate branchial arches and supports their common origin at the
160 2 isoforms have interchangeable functions in branchial arches and that Pitx2 target pathways respond
161 l elements derived from the first and second branchial arches and that there are heterogeneous popula
162 ctor dHAND is expressed in the mesenchyme of branchial arches and the developing heart.
163                          Indeed, the size of branchial arches and the frontonasal mass of mutant embr
164 os exhibited an increased number of somites, branchial arches and the presence of forelimb buds; howe
165 l crest cells are directed in streams to the branchial arches and to the forelimb of the developing q
166 ral crest cell migration and invasion of the branchial arches are separable processes.
167 it would in normal development, resulting in branchial arches containing mixed cell populations not o
168 expressed in the differentiating somites and branchial arches during embryogenesis and is skeletal mu
169 ing expression of AKAP95 and fidgetin in the branchial arches during mouse embryogenesis.
170 r element that drives Myf5 expression in the branchial arches from 9.5 days post-coitum and show that
171  this conclusion, Dlx6 was down-regulated in branchial arches from EdnrA mutant mice.
172 c ganglion neurons, but crest cells in other branchial arches generate many sensory neurons.
173 ventolateral regions of the first and second branchial arches in these mutant mice, but expression wa
174 T-1) mutant embryos, dHAND expression in the branchial arches is down-regulated, implicating it as a
175 hed during development and patterning of the branchial arches may set up signals that the neural plat
176        Migration into the presumptive caudal branchial arches of the lamprey involves both rostral an
177 o detection of DRR activity in limb buds and branchial arches of transgenic mice.
178 so lacked the early defects in growth of the branchial arches seen in Hand2 null embryos and survived
179                      Isolated E9.5 +/+ first branchial arches showed normal outgrowth of mouse ERG-po
180 onistic signals from the neural tube and the branchial arches specify extraocular versus branchiomeri
181 ed region contributes to a greater number of branchial arches than it would in normal development, re
182 ebrate face develop from transient embryonic branchial arches that are populated by cranial neural cr
183 he establishment of signaling centers in the branchial arches that are required for neural crest surv
184 re heterogeneous populations of cells in the branchial arches that rely on different cis-regulatory e
185 d from the neural tube that migrate into the branchial arches to generate the distinctive bone, conne
186 tic activity during NC cell migration to the branchial arches was altered when premigratory cells wer
187 maintain a spatially-ordered invasion of the branchial arches with differences in cell proliferation
188 enotypes that are both more severe (head and branchial arches) and less severe (allantois growth) tha
189 apped binding of Meis, Pbx, and Hoxa2 in the branchial arches, a series of segments in the developing
190 i3 mutants are able to migrate, populate the branchial arches, and display some elements of correct p
191 nt to the even-numbered rhombomeres into the branchial arches, and each stream contains contributions
192   In the olfactory pathway, as in the limbs, branchial arches, and heart, mesenchymal/epithelial indu
193 her sites of induction, including the limbs, branchial arches, and heart.
194 dition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hear
195 notochord, somites, heart, pronephric ducts, branchial arches, and jaw muscles in embryos and larvae.
196 mbryonic forebrain as well as aortic arches, branchial arches, and limb buds.
197 rtebrate primordia such as sensory placodes, branchial arches, and limb buds.
198  was found localized to the brain, eye, ear, branchial arches, and spinal cord.
199 ofound abnormalities in the first and second branchial arches, and the early remodeling of blood vess
200  and Hand2 transcription factor genes in the branchial arches, and we identify a branchial arch-speci
201 erge from the neural tube or en route to the branchial arches, areas where cell-cell interactions typ
202 itiation of MyoD expression in limb buds and branchial arches, as enhancer deletion delayed MyoD acti
203 2 is also expressed in Xenopus neural folds, branchial arches, cardiac outflow tract, inflow tract, a
204 in derivatives of neurogenic placodes and in branchial arches, despite the fact that cephalochordates
205 te host peripheral structures, including the branchial arches, dorsal root and sympathetic ganglia.
206 riants most likely perturb the patterning of branchial arches, either through excessive activity (und
207        Jaws are principally derived from the branchial arches, embryonic structures that exhibit prox
208  neural crest cells fail to fully invade the branchial arches, especially the 2nd branchial arch.
209 that HAND2 is involved in development of the branchial arches, heart, limb, vasculature, and nervous
210 s, including the craniofacial skeleton, ear, branchial arches, heart, lungs, diaphragm, gut, kidneys,
211 s, cranial nerve ganglia, hindbrain, retina, branchial arches, jaw, and fin buds.
212  the mesenchyme and endothelial cells of the branchial arches, outflow tract, and heart suggest that
213 erentiation of the cartilage elements in the branchial arches, rather than during crest migration, im
214  position of origin after migration into the branchial arches, resulting in skeletal abnormalities.
215 es mix along migration routes and within the branchial arches, separate groups of premigratory neural
216 ing the development of the allantois, heart, branchial arches, somites and forebrain.
217 mal lineage, including craniofacial regions, branchial arches, somites, vibrissal and hair follicles,
218 f the somites, the ventromedial pathway, the branchial arches, the gut, the sensory ganglia, and the
219 mbryo, including paraxial mesoderm, somites, branchial arches, vibrissae, developing central nervous
220 al cues in driving neural crest cells to the branchial arches, we isochronically transplanted small s
221 d crest-derived prechondrocytes in posterior branchial arches, whereas a third paralogue is expressed
222 xpressed in the distal (ventral) zone of the branchial arches, whereas the Hand2 expression domain ex
223 C development in the third, fourth and sixth branchial arches, while the bone malformations present i
224                     HGF was expressed in the branchial arches, whilst Met, which encodes an HGF recep
225 supports internal to the gills--the visceral branchial arches--represents one of the key events in ea
226 ding open neural tubes and reductions in the branchial arches.
227 exploit neural crest streams to populate the branchial arches.
228 stinct functions in mandibular versus caudal branchial arches.
229 tube and navigate over long distances to the branchial arches.
230 ls and are derived from the first and second branchial arches.
231 on, are all active in the oral epithelium or branchial arches.
232  and is required for dHAND expression in the branchial arches.
233 d hyomandibular and reduced third and fourth branchial arches.
234 control expression of dHAND in the heart and branchial arches.
235 ral crest cell migration into the developing branchial arches.
236 with defects of NCCs from the first to third branchial arches.
237 y elements that control transcription in the branchial arches.
238 of the neural tube, and neural crest derived branchial arches.
239 also causes apoptosis of neural crest in the branchial arches.
240 anglia, to their targets, the muscles of the branchial arches.
241 ndbrain neural crest cell migration into the branchial arches.
242 ence at the dorsal midline to entry into the branchial arches.
243 t cell migration streams bound for different branchial arches.
244 d close to the top of the clefts between the branchial arches.
245 ain, eyes, somites, ventral blood island and branchial arches.
246 ld faster doubling time after populating the branchial arches.
247 cations, with at least five operating in the branchial arches.
248 embryonic vasculature and development of the branchial arches.
249 ugh different microenvironments and into the branchial arches.
250 ry routes to precise targets in the head and branchial arches.
251 the development of the embryonic pharyngeal (branchial) arches, but its effects on innervation of the
252 d expression pattern in developing visceral (branchial) arches.
253 laterally from their hyoid and gill-bearing (branchial) arches.
254                    A striking feature is the branchial area with an array of bipartite bars.
255 s primitive and reinforces the view that the branchial basket of lampreys is probably derived.
256 s in hyoid cartilages and the more posterior branchial cartilages.
257  his right anterior neck was found to have a branchial cleft cyst infected with Bordetella bronchisep
258 ny affected subjects have been observed with branchial-cleft anomalies and hearing loss but without r
259  Espin also accumulated in the epithelium of branchial clefts and pharyngeal pouches and during branc
260 hial placodes produce sensory ganglia within branchial clefts.
261  correlation offers potential for the use of branchial Cu concentration as an indicator of long-term
262 cription factor Foxi3, which is expressed in branchial ectoderm and endoderm.
263 ndarily lost, concomitantly with the loss of branchial fissures, the acquisition of a feeding mechani
264 ngs had significant but transient effects on branchial function.
265 re localized in the oral and atrial siphons, branchial gill slits, endostyle, and gut.
266 The most common features of BOR syndrome are branchial, hearing, and renal anomalies.
267 dosis in fish that must be corrected through branchial ion transport.
268 rees C leads to preferential distribution of branchial ionocytes to the distal edges of the ILCM, whe
269 exposure of goldfish to hypoxia, the pool of branchial ionocytes was composed largely of pre-existing
270 y examined the time course and plasticity of branchial metabolic compensation in response to varying
271 ion formation leads to pathfinding errors of branchial motoneurons.
272  the tissue-specific roles of these genes in branchial nerve development shows that Sprouty gene dele
273  gene family on the early development of the branchial nerves.
274                                       Caudal branchial neural crest cells migrate ventrally as a shee
275  stain with neutral red and appear to be the branchial neuroepithelial cells.
276 der characterized by varying combinations of branchial, otic and renal anomalies, whereas deletion of
277 so exhibit natural variation with respect to branchial ray distribution--elasmobranchs (sharks and ba
278 and maintains the proliferative expansion of branchial ray endoskeletal progenitor cells.
279 incident with this transient Shh expression, branchial ray outgrowth is initiated in C. milii but is
280 age reduction by attenuation of Shh-mediated branchial ray outgrowth, and that chondrichthyan branchi
281                                              Branchial ray outgrowth, like tetrapod limb outgrowth, i
282 e the molecular patterning of chondrichthyan branchial rays (gill rays) and reveal profound developme
283 erning mechanisms employed by chondrichthyan branchial rays and paired fins/limbs, and provide mechan
284 chial ray outgrowth, and that chondrichthyan branchial rays and tetrapod limbs exhibit parallel devel
285  corresponds to the presence of fully formed branchial rays on the hyoid and gill arches.
286 y, we demonstrate that paired appendages and branchial rays share other conserved developmental featu
287 hyans possess endoskeletal appendages called branchial rays that extend laterally from their hyoid an
288 t laterally from their gill arches, known as branchial rays.
289  previously unrecognized vestigial gill arch branchial rays.
290              However, the arrangement of the branchial region in Metaspriggina has wider implications
291            Segmentation of the hindbrain and branchial region is a conserved feature of head developm
292  premigratory crest are relocated within the branchial region, crest cells retain patterns of gene ex
293 vigation of hypoglossal motor axons into the branchial region.
294 e describe the braincase, palatoquadrate and branchial skeleton of Tiktaalik roseae, the Late Devonia
295 esents with facial clefting, eye defects and branchial skin anomalies.
296  highest for flow exiting the most posterior branchial slit.
297 branchial slits, indicating that the slanted branchial slits between the gill arches are responsible
298 sent in the conical simulation with vertical branchial slits, indicating that the slanted branchial s
299 oral cavities possessing vertical or slanted branchial slits.
300 les of water exiting the oral cavity via the branchial slits.

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