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1 very large extended family whose members had branchial and hearing anomalies associated with commissu
3 To gain insight into the factors that guide branchial aortic arch development, we examined the proce
5 rders associated with the development of the branchial apparatus, and disorders associated with auton
8 yclopia, as well as alterations in the first branchial arch (BA1) leading to lack of jaw (agnathia).
11 heir nested expression patterns in the first branchial arch (primordium for jaw) and mutant phenotype
12 the rhombomere 4 (r4) migratory stream into branchial arch 2 (ba2), is due to chemoattraction throug
17 ts including cleft face (involving the first branchial arch and frontonasal processes), incomplete he
19 ral crest cells that migrate into the second branchial arch and is essential for proper patterning of
20 within the mandibular component of the first branchial arch and later in the primordia of middle ear-
25 presumptive secondary heart field within the branchial arch and splanchnic mesoderm that contributes
26 sumptive secondary heart field, derived from branchial arch and splanchnic mesoderm, patterns the for
27 es and of the maxillary process of the first branchial arch are integral to lip and primary palate de
29 ilure to establish the initial complement of branchial arch arteries in the caudal pharyngeal region.
30 -31, shows that the initial formation of the branchial arch arteries is not disturbed in ETA-/- or EC
31 cts that includes abnormal patterning of the branchial arch arteries, double-outlet right ventricle,
32 rentiation of smooth muscle cells within the branchial arch arteries, which are derived from the neur
36 n mice impairs asymmetric remodelling of the branchial arch artery (BAA) system, resulting in randomi
38 y fail to form neurons in cranial ganglia or branchial arch cartilage, illustrating that they are at
41 of Ph/Ph cells to PDGF-A treatment of normal branchial arch cells in vitro with recombinant PDGF-AA s
44 disorder characterized by the association of branchial arch defects, hearing loss, and renal anomalie
45 , including external ear anomalies, abnormal branchial arch derivatives, heart malformations, diaphra
48 ssing their differentiation, while a further branchial arch derived signal, namely Bmp7, is an overal
50 In mouse embryos, mutation of Prdm1 affects branchial arch development and leads to persistent trunc
51 To determine the potential role of dHAND in branchial arch development and to assess the role of the
52 1 reveals that it is essential for posterior branchial arch development, although the mandibular arch
57 elates with a delay in expression of Fgf8 in branchial arch ectoderm and a failure of neural crest ce
60 Endothelin-1 (ET-1) signaling regulates the branchial arch enhancer and is required for dHAND expres
66 ealed that geniculate axons were repelled by branchial arch explants that were previously shown to be
67 mesenchymal cells, cell migration from Ph/Ph branchial arch explants was compared to migration from n
68 e Hand2 allele or deleting the ventrolateral branchial arch expression of Hand2 led to a novel phenot
70 comparing protein binding to these sites in branchial arch extracts from endothelin receptor A (Ednr
72 there is a tight link between the resulting branchial arch Hox code and a particular skeletal morpho
73 resulting in the persistence of an abnormal branchial arch Hox code and extensive defects in the hyo
77 Overexpression of Hoxa2 in the chick first branchial arch leads to a transformation of first arch c
80 c sac mesothelium and in left splanchnic and branchial arch mesoderm near the junction of the aortic
84 ted to the lateral rectus and proximal first branchial arch muscles; many also contributed to the dor
85 ing has been implicated in somite, limb, and branchial arch myogenesis but the mechanisms and roles a
91 mus alters Hoxa2 expression and consequently branchial arch patterning, demonstrating that neural cre
92 reduction in head size after 1 day, loss of branchial arch structures after 2 days, and embryos with
94 s from adjoining rhombomeres within a single branchial arch support the notion that the pattern of hi
95 a from both human fetal ear and mouse second branchial arch tissue confirmed that genes located among
98 ent, whereas muscles derived from the second branchial arch were merely distorted in Pitx2 mutants at
99 ll-derived skeletal structures of the second branchial arch were morphologically transformed into ele
101 res 4 and 5, the selective loss of the 2(nd) branchial arch, and the loss of most, but not all, 2(nd)
102 and the mandible bone derive from the first branchial arch, and their development depends upon the c
103 t signaling in the epaxial somite and second branchial arch, but not in the limb or the first branchi
105 and defects in the derivatives of the first branchial arch, including cleft palate, suggesting a pro
106 llary and mandibular components of the first branchial arch, nasal processes, eyelid, midbrain, medul
107 shown to function as brain, olfactory bulb, branchial arch, otic vesicle and fin enhancers, recapitu
108 showed comparable expression patterns in the branchial arch, otic vesicle, forebrain and/or limb at e
109 -less gene family, is expressed in the first branchial arch, prior to the initiation of tooth develop
110 n factors required to initiate myogenesis in branchial arch- and somite-derived muscles are known, bu
111 ET-1/ECE-1/ETA pathway results in defects in branchial arch- derived craniofacial tissues, as well as
112 s of neural crest-derived tissues, including branchial arch-derived craniofacial structures, aortic a
113 utant mice are not viable and display severe branchial arch-derived facial skeleton defects, includin
115 stablishing a baseline molecular bauplan for branchial arch-derived jaw development and further valid
117 ocyte Growth Factor, although a component of branchial arch-mediated growth promotion and chemoattrac
119 s in the branchial arches, and we identify a branchial arch-specific enhancer in the Dlx5/6 locus, wh
140 allele resulted in abnormal morphogenesis of branchial-arch arteries (BAAs) and defective OFT septati
142 ecule is expressed in ventral splanchnic and branchial-arch mesoderm and outflow-tract (OFT) myocardi
144 signals in the vicinity of the hindbrain and branchial arches act on migrating myogenic cells to infl
145 gh muscles derived from the first and second branchial arches also share a clonal relationship with d
146 expression in epaxial and hypaxial somites, branchial arches and central nervous system, and argued
147 in the ectodermal surfaces of the limb buds, branchial arches and epidermal appendages, which are all
149 radation-1-like gene, expressed in embryonic branchial arches and in the conotruncus, appears to play
152 erted from their migration pathways into the branchial arches and instead migrated around the otic ve
153 ression disrupts morphogenesis of the caudal branchial arches and leads to a failure to correctly ela
155 e skeletal muscle precursors of the myotome, branchial arches and limbs as well as in the developing
156 pressed in midgestation mouse embryos in the branchial arches and limbs, consistent with the human ph
159 rk sheds light on the homology of vertebrate branchial arches and supports their common origin at the
160 2 isoforms have interchangeable functions in branchial arches and that Pitx2 target pathways respond
161 l elements derived from the first and second branchial arches and that there are heterogeneous popula
164 os exhibited an increased number of somites, branchial arches and the presence of forelimb buds; howe
165 l crest cells are directed in streams to the branchial arches and to the forelimb of the developing q
167 it would in normal development, resulting in branchial arches containing mixed cell populations not o
168 expressed in the differentiating somites and branchial arches during embryogenesis and is skeletal mu
170 r element that drives Myf5 expression in the branchial arches from 9.5 days post-coitum and show that
173 ventolateral regions of the first and second branchial arches in these mutant mice, but expression wa
174 T-1) mutant embryos, dHAND expression in the branchial arches is down-regulated, implicating it as a
175 hed during development and patterning of the branchial arches may set up signals that the neural plat
178 so lacked the early defects in growth of the branchial arches seen in Hand2 null embryos and survived
180 onistic signals from the neural tube and the branchial arches specify extraocular versus branchiomeri
181 ed region contributes to a greater number of branchial arches than it would in normal development, re
182 ebrate face develop from transient embryonic branchial arches that are populated by cranial neural cr
183 he establishment of signaling centers in the branchial arches that are required for neural crest surv
184 re heterogeneous populations of cells in the branchial arches that rely on different cis-regulatory e
185 d from the neural tube that migrate into the branchial arches to generate the distinctive bone, conne
186 tic activity during NC cell migration to the branchial arches was altered when premigratory cells wer
187 maintain a spatially-ordered invasion of the branchial arches with differences in cell proliferation
188 enotypes that are both more severe (head and branchial arches) and less severe (allantois growth) tha
189 apped binding of Meis, Pbx, and Hoxa2 in the branchial arches, a series of segments in the developing
190 i3 mutants are able to migrate, populate the branchial arches, and display some elements of correct p
191 nt to the even-numbered rhombomeres into the branchial arches, and each stream contains contributions
192 In the olfactory pathway, as in the limbs, branchial arches, and heart, mesenchymal/epithelial indu
194 dition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hear
195 notochord, somites, heart, pronephric ducts, branchial arches, and jaw muscles in embryos and larvae.
199 ofound abnormalities in the first and second branchial arches, and the early remodeling of blood vess
200 and Hand2 transcription factor genes in the branchial arches, and we identify a branchial arch-speci
201 erge from the neural tube or en route to the branchial arches, areas where cell-cell interactions typ
202 itiation of MyoD expression in limb buds and branchial arches, as enhancer deletion delayed MyoD acti
203 2 is also expressed in Xenopus neural folds, branchial arches, cardiac outflow tract, inflow tract, a
204 in derivatives of neurogenic placodes and in branchial arches, despite the fact that cephalochordates
205 te host peripheral structures, including the branchial arches, dorsal root and sympathetic ganglia.
206 riants most likely perturb the patterning of branchial arches, either through excessive activity (und
208 neural crest cells fail to fully invade the branchial arches, especially the 2nd branchial arch.
209 that HAND2 is involved in development of the branchial arches, heart, limb, vasculature, and nervous
210 s, including the craniofacial skeleton, ear, branchial arches, heart, lungs, diaphragm, gut, kidneys,
212 the mesenchyme and endothelial cells of the branchial arches, outflow tract, and heart suggest that
213 erentiation of the cartilage elements in the branchial arches, rather than during crest migration, im
214 position of origin after migration into the branchial arches, resulting in skeletal abnormalities.
215 es mix along migration routes and within the branchial arches, separate groups of premigratory neural
217 mal lineage, including craniofacial regions, branchial arches, somites, vibrissal and hair follicles,
218 f the somites, the ventromedial pathway, the branchial arches, the gut, the sensory ganglia, and the
219 mbryo, including paraxial mesoderm, somites, branchial arches, vibrissae, developing central nervous
220 al cues in driving neural crest cells to the branchial arches, we isochronically transplanted small s
221 d crest-derived prechondrocytes in posterior branchial arches, whereas a third paralogue is expressed
222 xpressed in the distal (ventral) zone of the branchial arches, whereas the Hand2 expression domain ex
223 C development in the third, fourth and sixth branchial arches, while the bone malformations present i
225 supports internal to the gills--the visceral branchial arches--represents one of the key events in ea
251 the development of the embryonic pharyngeal (branchial) arches, but its effects on innervation of the
257 his right anterior neck was found to have a branchial cleft cyst infected with Bordetella bronchisep
258 ny affected subjects have been observed with branchial-cleft anomalies and hearing loss but without r
259 Espin also accumulated in the epithelium of branchial clefts and pharyngeal pouches and during branc
261 correlation offers potential for the use of branchial Cu concentration as an indicator of long-term
263 ndarily lost, concomitantly with the loss of branchial fissures, the acquisition of a feeding mechani
268 rees C leads to preferential distribution of branchial ionocytes to the distal edges of the ILCM, whe
269 exposure of goldfish to hypoxia, the pool of branchial ionocytes was composed largely of pre-existing
270 y examined the time course and plasticity of branchial metabolic compensation in response to varying
272 the tissue-specific roles of these genes in branchial nerve development shows that Sprouty gene dele
276 der characterized by varying combinations of branchial, otic and renal anomalies, whereas deletion of
277 so exhibit natural variation with respect to branchial ray distribution--elasmobranchs (sharks and ba
279 incident with this transient Shh expression, branchial ray outgrowth is initiated in C. milii but is
280 age reduction by attenuation of Shh-mediated branchial ray outgrowth, and that chondrichthyan branchi
282 e the molecular patterning of chondrichthyan branchial rays (gill rays) and reveal profound developme
283 erning mechanisms employed by chondrichthyan branchial rays and paired fins/limbs, and provide mechan
284 chial ray outgrowth, and that chondrichthyan branchial rays and tetrapod limbs exhibit parallel devel
286 y, we demonstrate that paired appendages and branchial rays share other conserved developmental featu
287 hyans possess endoskeletal appendages called branchial rays that extend laterally from their hyoid an
292 premigratory crest are relocated within the branchial region, crest cells retain patterns of gene ex
294 e describe the braincase, palatoquadrate and branchial skeleton of Tiktaalik roseae, the Late Devonia
297 branchial slits, indicating that the slanted branchial slits between the gill arches are responsible
298 sent in the conical simulation with vertical branchial slits, indicating that the slanted branchial s
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