ライフサイエンスコーパス: branching morphogenesis

1 howed increased proliferation and precocious branching morphogenesis.

2 mbly and governs rates of cell migration and branching morphogenesis.

3 through actomyosin contractility to support branching morphogenesis.

4 ng rules and proposed unifying principles of branching morphogenesis.

5 al differentiation and subsequent epithelial branching morphogenesis.

6 rostate specification, ductal outgrowth, and branching morphogenesis.

7 and are required in cleft progression during branching morphogenesis.

8 rearrangements that may contribute to renal branching morphogenesis.

9 egarding the function of these parameters in branching morphogenesis.

10 ammary fat pad are axially oriented prior to branching morphogenesis.

11 or the transcription factor Sox9 during lung branching morphogenesis.

12 racellular matrix (ECM) is a crucial step in branching morphogenesis.

13 vs. mesenchymal cells in an organ undergoing branching morphogenesis.

14 7) supported gland survival and enhanced SMG branching morphogenesis.

15 ng candidate genes that potentially regulate branching morphogenesis.

16 ons that direct ECM remodeling during airway branching morphogenesis.

17 edback inhibition and thus regulated mammary branching morphogenesis.

18 ic modes used during growth factor-initiated branching morphogenesis.

19 via epithelial-mesenchymal interactions and branching morphogenesis.

20 complex activity is required for subcellular branching morphogenesis.

21 an upstream regulator of Grem1 in initiating branching morphogenesis.

22 GREM1 protein restores ampulla formation and branching morphogenesis.

23 and the ability to undergo distinct forms of branching morphogenesis.

24 n linking mechanosensing to endothelial cell branching morphogenesis.

25 y coordinated with ASM formation during lung branching morphogenesis.

26 xerts an inhibitory effect on salivary gland branching morphogenesis.

27 pecification of basal cell number influences branching morphogenesis.

28 g in the blastema, which undergoes extensive branching morphogenesis.

29 s HS modification is important for robust UB branching morphogenesis.

30 e identified Btbd7 as a dynamic regulator of branching morphogenesis.

31 al ducts extend into the fat pad and undergo branching morphogenesis.

32 mammalian lung are generated by a process of branching morphogenesis.

33 ncreasing proximal-to-distal gradient during branching morphogenesis.

34 wn function for Fgf20 in mammary budding and branching morphogenesis.

35 ream of Ret that promotes and controls renal branching morphogenesis.

36 role for Klf6 in the regulation of prostate branching morphogenesis.

37 epimorphin/syntaxin-2 can stimulate mammary branching morphogenesis.

38 significantly increased ductal extension and branching morphogenesis.

39 emodeling in high-density gels, resulting in branching morphogenesis.

40 ical and morphological changes necessary for branching morphogenesis.

41 normal mammary epithelial proliferation and branching morphogenesis.

42 s required for mammary epithelial growth and branching morphogenesis.

43 mal microenvironment regulates mammary gland branching morphogenesis.

44 eolysis with epithelial proliferation during branching morphogenesis.

45 e epithelium, were associated with increased branching morphogenesis.

46 eading to more aggressive cell outgrowth and branching morphogenesis.

47 tions and possibly cell rearrangement during branching morphogenesis.

48 endoderm undergoes extensive and stereotypic branching morphogenesis.

49 both pyrethroids, including some relating to branching morphogenesis.

50 ment and suggest a role for these neurons in branching morphogenesis.

51 cell adhesion and motility during epithelial branching morphogenesis.

52 distal compartment before the initiation of branching morphogenesis.

53 cluding axial patterning of the endoderm and branching morphogenesis.

54 g new opportunities for future research into branching morphogenesis.

55 epithelium from the bud stage and throughout branching morphogenesis.

56 ote subsequent splitting of the tip to allow branching morphogenesis.

57 together in the lung mesenchyme to maintain branching morphogenesis.

58 hich inhibits p38MAPK activity and decreases branching morphogenesis.

59 -level regulatory network essential for lung branching morphogenesis.

60 helial cell apical-basal polarity and tissue branching morphogenesis.

61 model in which these cell movements mediate branching morphogenesis.

62 of epithelial progenitor cells that impairs branching morphogenesis.

63 uired for terminal bifurcation during airway branching morphogenesis.

64 lium develops into a tree-like structure via branching morphogenesis.

65 y proteins are regulators of cell growth and branching morphogenesis.

66 as well as a severe disruption of labyrinth branching morphogenesis.

67 abilize pouch epithelial cells at the end of branching morphogenesis.

68 d physical mechanisms that can contribute to branching morphogenesis.

69 Branching morphogenesis, a fundamental process in the de

70 from the ureteric bud (UB), which undergoes branching morphogenesis, a process regulated by multiple

71 During branching morphogenesis, a simple cluster of cells proli

72 , recombinant collagen IV NC1 domains rescue branching morphogenesis after MT2-siRNA treatment, incre

73 cental differentiation that included reduced branching morphogenesis, alterations in maternal and fet

74 n lung hypoplasia characterized by defective branching morphogenesis, altered cellular energetics and

75 oskeletal regulators required for intestinal branching morphogenesis and a modulator of bioactive sph

76 We find a negative correlation between branching morphogenesis and alveolar differentiation tem

77 ial progenitors continuously balance between branching morphogenesis and alveolar differentiation, an

78 nificant associations between the profile of branching morphogenesis and both cancer models.

79 ical modeling has been limited to acinar and branching morphogenesis and breast cancer, without refer

80 regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.

81 kinase activation, impaired prostatic ductal branching morphogenesis and compromised cell proliferati

82 However, JNK1/2 deficiency caused increased branching morphogenesis and defects in the clearance of

83 and uncover the critical function of Dlg5 in branching morphogenesis and differentiation of lung prog

84 y 18.5, SMGs from wild-type mice showed duct branching morphogenesis and differentiation of tubule du

85 ervous and immune systems and salivary gland branching morphogenesis and discuss new insights concern

86 /loxP) mice exhibited significant defects in branching morphogenesis and ductal outgrowth compared wi

87 hown that Cripto-1 is involved in regulating branching morphogenesis and epithelial-mesenchymal trans

88 Both LIMK 1 and 2 were necessary for branching morphogenesis and functioned to promote epithe

89 e report that Gpr54 deletion leads to kidney branching morphogenesis and glomerular development retar

90 plays an important role in embryonic kidney branching morphogenesis and glomerular development.

91 longing to the MT-MMP and ADAMTS families in branching morphogenesis and interdigital web regression.

92 ptor (Smed-EGFR-5) as a crucial regulator of branching morphogenesis and maintenance.

93 RP2/FAK signaling axis that is important for branching morphogenesis and mammary gland development.

94 such as CD44 that are important for prostate branching morphogenesis and metastasis to the bone micro

95 disorder characterized by defective ureteric branching morphogenesis and nephrogenesis, ranks as one

96 erful and quantitative means to characterize branching morphogenesis and nephrogenesis.

97 stitutes a likely general mechanism to guide branching morphogenesis and other symmetry breaks during

98 t mice have gross defects in chorioallantoic branching morphogenesis and placental vascular patternin

99 The lacrimal gland (LG) develops through branching morphogenesis and produces secretions, includi

100 e kinase protein Dlg5 is required for proper branching morphogenesis and progenitor differentiation i

101 evelopment with lung buds failing to undergo branching morphogenesis and progressive atrophy of the p

102 nducible loss of Dnm2 in endothelium impairs branching morphogenesis and promotes the accumulation of

103 t not Smad5, resulted in retardation of lung branching morphogenesis and reduced sacculation, accompa

104 spensable in epithelial progenitors for both branching morphogenesis and sacculation.

105 istinct morphogenetic processes: subcellular branching morphogenesis and subcellular apical lumen for

106 lpha3 chain-containing LMs promote normal UB branching morphogenesis and that LM-332 is a better subs

107 Aberrant branching morphogenesis and tubulogenesis were also obse

108 Embryonic metanephric kidneys also undergo branching morphogenesis and Vangl2 is known to be expres

109 ration level of salivary cells, disorganized branching morphogenesis, and a lack of differentiated mu

110 ic progenitor cell proliferation, defects in branching morphogenesis, and a subsequent failure to ind

111 al paracrine modulator of epithelial growth, branching morphogenesis, and epithelial gene expression.

112 ving the complex dynamics of epithelial cell branching morphogenesis, and in nephron patterning.

113 l step in submandibular salivary gland (SMG) branching morphogenesis, and may result from localized a

114 developmental stages of prostate induction, branching morphogenesis, and secretory differentiation.

115 -epithelial transition, inductive signaling, branching morphogenesis, and segmentation.

116 atterning, lung specification, lung budding, branching morphogenesis, and, finally, maturation.

117 he molecular signaling pathways that control branching morphogenesis appear to be conserved across or

118 Here, the principles of branching morphogenesis are exemplified by the mammary g

119 h the mechanisms by which they contribute to branching morphogenesis are not defined.

120 ern research tools, our conceptual models of branching morphogenesis are rapidly evolving, and the di

121 Budding, lobation and branching morphogenesis are unaffected in early stage Fg

122 e of mammary stem cells (MaSCs), which drive branching morphogenesis, are unknown.

123 analysis of gene expression data identified branching morphogenesis as a biological process sensitiv

124 The lungs are generated by branching morphogenesis as a result of reciprocal signal

125 rgeted deletion impairs ductal expansion and branching morphogenesis as well as cell proliferation in

126 thelial cells (ECs) impairs their sprouting, branching morphogenesis, axial polarity, and normal disp

127 Npas3-null mice have reduced lung branching morphogenesis but are viable prenatally.

128 ranscription factor NFIB is not required for branching morphogenesis but plays a key role in tubule c

129 gland, lumen formation takes place alongside branching morphogenesis, but in a controlled manner, so

130 rm and the underlying mesenchyme during lung branching morphogenesis, but little is known about how t

131 Proteolysis is essential during branching morphogenesis, but the roles of MT-MMPs and th

132 Eda regulates mammary placode formation and branching morphogenesis, but the underlying molecular me

133 enchymal interactions play a crucial role in branching morphogenesis, but very little is known about

134 clude that Sox9 collectively promotes proper branching morphogenesis by controlling the balance betwe

135 naling through Pak2a thus signals the end of branching morphogenesis by increasing intercellular adhe

136 er, these data demonstrate that Ilk controls branching morphogenesis by regulating the expression of

137 sal polarity, and epithelial motility during branching morphogenesis can be applied to understand the

138 mesenchyme leads to ectopic and disorganized branching morphogenesis caused by beta-catenin directly

139 ntify kidney-specific and shared programs of branching morphogenesis, comparative expression studies

140 Branching morphogenesis creates arborized epithelial net

141 g MT-MMP activity during submandibular gland branching morphogenesis decreases proliferation and incr

142 e imaging and transcriptome analysis of lung-branching morphogenesis demonstrate that Fzd2 promotes c

143 In the lacrimal gland, branching morphogenesis depends on the interaction of he

144 Branching morphogenesis depends on the precise temporal

145 he vasculature, the developmental program of branching morphogenesis during angiogenesis is controlle

146 Macrophages are important regulators of branching morphogenesis during development and postnatal

147 Thus beta1 integrins can regulate organ branching morphogenesis during development by mediating

148 CPAM is thought to result from abnormal branching morphogenesis during fetal lung development, a

149 tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney development, yet f

150 rized invasion of trophoblasts and efficient branching morphogenesis during placental development, bu

151 ns as a polarity protein required for proper branching morphogenesis during placental development.

152 letal dynamics that mediate endothelial cell branching morphogenesis during vascular guidance are tho

153 specification of epithelial progenitors and branching morphogenesis earlier than previously apprecia

154 and late lung development that affect airway branching morphogenesis, epithelial cell differentiation

155 n has long been thought to drive stereotypic branching morphogenesis even though isolated lung epithe

156 Expression of genes involved in branching morphogenesis, Gcm1, Syna and Synb, and in pat

157 gands act as solid-phase agonists to promote branching morphogenesis, growth and water transport func

158 While the genetic control of renal branching morphogenesis has been extensively described,

159 The mechanisms that control axonal branching morphogenesis have been studied intensively, y

160 ature co-develops with the epithelium during branching morphogenesis; however, it is not known whethe

161 we explore how the regulatory mechanisms of branching morphogenesis identified in other models, and

162 lium through targeted deletion leads to poor branching morphogenesis, impaired terminal end bud forma

163 rved that VEGF(165), an NRP2 ligand, induces branching morphogenesis in 3D cultures and that branchin

164 of breast cancer cells and induces abnormal branching morphogenesis in 3D cultures.

165 Knockdown of pleiotrophin influenced lung branching morphogenesis in a fetal lung organ culture mo

166 ng hypothesis that directional outgrowth and branching morphogenesis in a variety of tissues are infl

167 regulates the normal invasive mammary gland branching morphogenesis in an epithelial cell extrinsic

168 Defects in airway branching morphogenesis in association with impaired epi

169 function as "switches" to regulate stages of branching morphogenesis in developing mammalian organs,

170 rate that ACKR2 is an important regulator of branching morphogenesis in diverse biological contexts a

171 Antisense knockdown of Adamts16 inhibited branching morphogenesis in kidney organ cultures.

172 and Notch are crucial for tube formation and branching morphogenesis in many systems, but the specifi

173 rmore, Malat1 loss results in a reduction of branching morphogenesis in MMTV-PyMT- and Her2/neu-ampli

174 l as similarities to Ras-mediated control of branching morphogenesis in more complex organs, includin

175 Considering the importance of branching morphogenesis in multiple taxa, our findings h

176 Exogenous FGF10 rescues branching morphogenesis in Npas3-null lungs.

177 outcome showed that the process of vascular branching morphogenesis in Ott1-deficient animals was re

178 ics parameters in endothelial cells to guide branching morphogenesis in physically complex ECMs.

179 to restore impaired arterial development and branching morphogenesis in synectin-deficient mice and s

180 has also enabled the factors that influence branching morphogenesis in the embryonic and pubertal gl

181 Here, we have found that branching morphogenesis in the embryonic chicken lung re

182 rameters regulating cleft progression during branching morphogenesis in the epithelial tissue of an e

183 Therefore, PTPRB regulates branching morphogenesis in the mammary epithelium by mod

184 Branching morphogenesis in the mammary gland is achieved

185 Here, we reveal reciprocal regulation of branching morphogenesis in the mammary gland, whereby st

186 MMP3 has been shown to regulate branching morphogenesis in the mammary gland.

187 NF2, LATS1/2 and YAP play a critical role in branching morphogenesis in the mouse kidney.

188 rk sheds light on the physical mechanisms of branching morphogenesis in the mouse lung.

189 demonstrate that PTPRB negatively regulates branching morphogenesis in the mouse mammary epithelium.

190 he isolated Hs2st null UB is able to undergo branching morphogenesis in the presence of exogenous sol

191 Modeling of branching morphogenesis in vitro defined specific defect

192 last growth factor-2 (FGF2) to model mammary branching morphogenesis in vitro.

193 esion kinase (FAK) and promote FAK-dependent branching morphogenesis in vitro.

194 the contribution of ILK-p38MAPK signaling to branching morphogenesis in vivo is not defined.

195 ed Fgf10 expression is not required for lung branching morphogenesis in vivo.

196 report that Btbd7 is a crucial regulator of branching morphogenesis in vivo.

197 establish a model for post-pubertal mammary branching morphogenesis in which position-dependent, lin

198 vel findings regarding pyrethroid effects on branching morphogenesis indicate these compounds may act

199 nctions including ureteric bud formation and branching morphogenesis, indicating that RA-receptor sig

200 Here we report that mammary branching morphogenesis induced by transforming growth f

201 butyl Amiloride (MIA) dramatically disrupted branching morphogenesis, induced extensive proliferation

202 Branching morphogenesis is a complex biological process

203 Branching morphogenesis is a fundamental program for tis

204 Lung branching morphogenesis is a highly orchestrated process

205 Branching morphogenesis is a molecularly conserved mecha

206 understood, at the cellular level, how renal branching morphogenesis is achieved or how Ret signaling

207 an in specific growth zones, suggesting that branching morphogenesis is achieved primarily by remodel

208 g of the epithelial basement membrane during branching morphogenesis is also essential to promote mat

209 Prostatic branching morphogenesis is an intricate event requiring

210 Branching morphogenesis is essential for the formation o

211 Lp) embryos, subsequent in vivo and in vitro branching morphogenesis is impaired.

212 We demonstrate that early UB branching morphogenesis is not primarily modulated by fa

213 Mammary branching morphogenesis is regulated by receptor tyrosin

214 xplant culture model in vitro show that lung branching morphogenesis is sensitive to [Ca(2+)](o), bei

215 ormation during submandibular salivary gland branching morphogenesis is the critical step initiating

216 Branching morphogenesis is the developmental program tha

217 Currently, branching morphogenesis is thought to depend on the mobi

218 logical processes such as cell migration and branching morphogenesis, little is known about how these

219 o understand mouse submandibular gland (SMG) branching morphogenesis, little is known about SMG cell

220 During branching morphogenesis, new branches form by "budding"

221 The first round of branching morphogenesis occurs during embryogenesis, and

222 enchymal cross-talk are critical to ensuring branching morphogenesis occurs properly.

223 ns indicated their involvement in apoptosis, branching morphogenesis of axons, cortical neurons, and

224 ed changes in polyamine homeostasis affected branching morphogenesis of cultured murine embryonic kid

225 Branching morphogenesis of developing organs requires co

226 Branching morphogenesis of epithelia is an important mec

227 nisms driving the formation, elongation, and branching morphogenesis of epithelial tubes during devel

228 We have shown that branching morphogenesis of mammary ductal structures req

229 hanical and biochemical signaling to control branching morphogenesis of mammary epithelial cells.

230 E47 can promote collective migration during branching morphogenesis of mammary epithelial tissues th

231 ranscription factors and the EMT proteome in branching morphogenesis of mammary epithelial tissues us

232 Genetic ablation of Btbd7 in mice disrupts branching morphogenesis of salivary gland, lung and kidn

233 ronectin (Fn) plays an important part in the branching morphogenesis of salivary gland, lung, and kid

234 Branching morphogenesis of the epithelial ureteric bud f

235 djacent epithelial progenitor cells to alter branching morphogenesis of the epithelium.

236 These results provide new insights into branching morphogenesis of the intrahepatic biliary netw

237 In support of this notion, branching morphogenesis of the isolated UB was found to

238 We propose that Adamts16 is involved in branching morphogenesis of the kidneys in mice.

239 ostnatal development, Cripto-1 regulates the branching morphogenesis of the mouse mammary gland and e

240 We have shown previously that during branching morphogenesis of the mouse prostate gland, Bon

241 s that plays an essential role in regulating branching morphogenesis of the ocular glands.

242 The kidney collecting system develops from branching morphogenesis of the ureteric bud (UB).

243 phin for cell adhesion, gene activation, and branching morphogenesis onto the inactive syntaxin-1a te

244 l cells of the developing lung did not alter branching morphogenesis or early mesenchymal differentia

245 enitor cell expansion and migration known as branching morphogenesis, or tubulogenesis, which proceed

246 date the role of variable HS sulfation in UB branching morphogenesis, particularly the role of 6-O su

247 Epithelial deletion of Wls disrupted lung branching morphogenesis, peripheral lung development and

248 Deletion at E10.5 resulted in a severe branching morphogenesis phenotype.

249 FGF signaling is a central regulator of branching morphogenesis processes, such as angiogenesis

250 or MMPs described here may not be limited to branching morphogenesis processes.

251 kidneys with HDACi impairs the ureteric bud branching morphogenesis program and provokes growth arre

252 Here we show that an epithelial branching morphogenesis program antagonizes alveolar dif

253 ther, the expression of genes comprising the branching morphogenesis program, such as PRDX4, SLC43A1,

254 A first wave of branching morphogenesis progresses throughout embryonic

255 suggest that S100A4-mediated effects during branching morphogenesis provide a plausible mechanism fo

256 elial cells caused retardation of early lung branching morphogenesis, reduced cell proliferation, and

257 stem cells that participate in mammary gland branching morphogenesis remain contested.

258 Branching morphogenesis requires the coordinated interpl

259 Tissue branching morphogenesis requires the hierarchical organi

260 and found it severely disrupted with reduced branching morphogenesis, resulting in fewer epithelial s

261 Primary defects in lung branching morphogenesis, resulting in neonatal lethal pu

262 We observed that branching morphogenesis results from the active motility

263 architecture of these glands is generated by branching morphogenesis, revealed by recent research to

264 Branching morphogenesis sculpts the airway epithelium of

265 he lung epithelium led to a striking halt in branching morphogenesis shortly after secondary branch f

266 , and Egf family ligands stimulate embryonic branching morphogenesis, suggesting that these pathways

267 creased Hedgehog [15, 16] signaling decrease branching morphogenesis, suggesting that Wnt and Hedgeho

268 -) mice have more severe defects in ureteric branching morphogenesis than previously reported, includ

269 the ureteric bud (UB) lineage causes loss of branching morphogenesis that is rescued by loss of one c

270 he insect respiratory system, to investigate branching morphogenesis that occurs at the single cell l

271 ility and invasiveness are essential for the branching morphogenesis that occurs during development o

272 how that transmural pressure controls airway branching morphogenesis, the frequency of airway smooth

273 During the process of branching morphogenesis, the mammary gland undergoes dis

274 Branching morphogenesis, the process by which cells or t

275 oordinated gene network controls trophoblast branching morphogenesis, thereby facilitating developmen

276 basement membrane is assumed to occur during branching morphogenesis to accommodate epithelial growth

277 Many mammalian organs undergo branching morphogenesis to create highly arborized struc

278 and development, an epithelial bud undergoes branching morphogenesis to expand into a continuous tree

279 ounded by mesenchyme, and it undergoes rapid branching morphogenesis to form a complex secretory orga

280 ric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting sys

281 Many embryonic organs undergo branching morphogenesis to maximize their functional epi

282 basement membrane remodeling is required for branching morphogenesis to regulate cell-matrix and cell

283 Although neither proteinase is required for branching morphogenesis, transcriptome profiling reveals

284 then established a 3D cell culture model of branching morphogenesis using primary pancreatic duct ce

285 sms that underlie critical processes such as branching morphogenesis, vascular development, and the d

286 GFR-mediated epithelial proliferation during branching morphogenesis via a Vldlr-dependent mechanism.

287 In addition, HGF-induced mammary epithelial branching morphogenesis was significantly reduced in Eph

288 ferentiate into tubule secretory cells while branching morphogenesis was unaffected.

289 sion atlas to search for novel regulators of branching morphogenesis, we found a substantial reductio

290 t separately model distinct stages of kidney branching morphogenesis, we found that the Hs2st(-/-) UB

291 bmandibular glands (SMGs) as models to study branching morphogenesis, we have identified new vectors

292 genes regulating early tissue patterning and branching morphogenesis were differentially regulated.

293 expression patterns and possible function in branching morphogenesis were investigated.

294 yoepithelial, and stromal cells during early branching morphogenesis when epithelial ducts extend int

295 l lung requires two developmental processes: branching morphogenesis, which builds a tree-like tubula

296 tecture of the mammary gland is generated by branching morphogenesis, which is regulated by many sign

297 al cells cultured ex vivo exhibited enhanced branching morphogenesis, which was reduced upon MAPK inh

298 1 to promote cholangiocyte specification and branching morphogenesis while concomitantly suppressing

299 Salivary glands are formed by branching morphogenesis with epithelial progenitors form

300 g that controls primary branch formation and branching morphogenesis within the kidney.