ライフサイエンスコーパス: breakpoint

1 cerebral metabolic reduction near the apnoea breakpoint.

2 (EUCAST) S. pseudintermedius cefoxitin disk breakpoint.

3 plain the reduction in CMRO2 near the apnoea breakpoint.

4 ts if interpreted by using the M100-S25 CoNS breakpoint.

5 same type and occurred on both sides of the breakpoint.

6 ication at the location of the recombination breakpoint.

7 ced at two characteristic distances from the breakpoint.

8 uct concentrations remained similar near the breakpoint.

9 equences homologous to those surrounding the breakpoint.

10 he breakpoint (2010), and no trend after the breakpoint.

11 ndations and informs the setting of clinical breakpoints.

12 Clinical and Laboratory Standards Institute breakpoints.

13 Clinical and Laboratory Standards Institute breakpoints.

14 bial agents or for older agents with updated breakpoints.

15 ibution and overlapping microhomology at the breakpoints.

16 f a 37.6-kilobase pair region with identical breakpoints.

17 cription and Pol2 stalling, were detected at breakpoints.

18 as A-tracts occur preferentially at deletion breakpoints.

19 ion between PONDS-forming repeats and cancer breakpoints.

20 respective of gene distance to the inversion breakpoints.

21 certainties about susceptibility testing and breakpoints.

22 Vitek 2 breakpoints and 95.7% using the CLSI breakpoints.

23 as well as a proposal of new susceptibility breakpoints.

24 drug resistance and choice of susceptibility breakpoints.

25 breakpoints, and (ii) the 2014 CLSI M100-S24 breakpoints.

26 sion transcripts spanning both the 5' and 3' breakpoints.

27 are disrupted, fused, and/or misregulated by breakpoints.

28 sitivity, gene disruption, or gene fusion at breakpoints.

29 quently maps split reads to identify precise breakpoints.

30 ilar profiles of escalation and increases in breakpoints.

31 genomic annotations and manual refinement of breakpoints.

32 ek 2 breakpoints and 8 (0.5%) using the CLSI breakpoints.

33 , mostly originating from the surrounding of breakpoints.

34 92.3%, and 95.5%, respectively, by the CLSI breakpoints.

35 he latter forming complex tandem duplication breakpoints.

36 d induced structural rearrangements with PSS breakpoints.

37 it more effectively utilized reads spanning breakpoints.

38 egment copy number, and clone specificity of breakpoints.

39 m, called Pegasus, accurately calls deletion breakpoints.

40 breakpoints and 2016 CLSI M100S 26th edition breakpoints.

41 breakpoints and 2016 CLSI M100S 26th edition breakpoints.

42 or or major errors noted when using the CLSI breakpoints.

43 anism for generating duplicated sequences at breakpoints.

44 at, or in close proximity to, rearrangement breakpoints.

45 ed to have additional mutations around their breakpoints.

46 aboratory Standards Institute guidelines and breakpoints.

47 (cefazolin) and 8 VMEs (0.5%) using the CLSI breakpoints (2 each for aztreonam, cefepime, and ceftria

48 decreasing slope (-8.1% per year) before the breakpoint (2010), and no trend after the breakpoint.

49 s having early tears if they tore before the breakpoint (38/55 eyes [69%]), and as late tears if they

50 uplications starting at 9.68 Mb with similar breakpoints across samples.

51 01-S2 (disk and MIC) and M100-S25 CoNS (MIC) breakpoints agreed with the results of mecA/mecC PCR for

52 Yet, the breakpoints also appeared in C2 (5.2%) and C5 (4.6%) dom

53 Large genomic rearrangements with intragenic breakpoints altering key regulatory genes involved in PD

54 Breakpoint analysis showed that the predominant mechanis

55 negative Staphylococcus (CoNS) oxacillin MIC breakpoint and cefoxitin disk breakpoint, the CLSI VET01

56 , binds to androgen receptor at the ERG gene breakpoint and inhibits both the juxtaposition of the TM

57 e cefepime Enterobacteriaceae susceptibility breakpoint and introduced the susceptible-dose-dependent

58 Both the human MATR3 translocation breakpoint and the mouse Matr3(Gt-ex13) gene trap insert

59 comparable to that of BMD using both Vitek 2 breakpoints and 2016 CLSI M100S 26th edition breakpoints

60 reement (CA) was assessed using both Vitek 2 breakpoints and 2016 CLSI M100S 26th edition breakpoints

61 ine chromothripsis events involving up to 65 breakpoints and 60.6 Mb across four chromosomes, further

62 rs (MEs) (0.4%) were noted using the Vitek 2 breakpoints and 8 (0.5%) using the CLSI breakpoints.

63 l agreement was 95.5% (CA) using the Vitek 2 breakpoints and 95.7% using the CLSI breakpoints.

64 resent methods to detect human/vector genome breakpoints and a user-friendly visualization tool for t

65 eus/Staphylococcus lugdunensis oxacillin MIC breakpoints and cefoxitin disk and MIC breakpoints, the

66 need for precise knowledge of translocation breakpoints and it extends traditional FISH by its quant

67 ltaneously, preserving uncertainty as to the breakpoints and magnitude of CNVs present in an individu

68 BD5-specific signal (PSS) sequences at their breakpoints and recurrently inactivated tumor-suppressor

69 quences of 65 individual DI-RNAs, identified breakpoints and reinitiation sites, and predicted their

70 To map inversion breakpoints and study potential diversity in descendants

71 sue-of-origin influences the position of CNA breakpoints and the properties of the resulting CNAs.

72 arental origin of all de novo chromothripsis breakpoints and to resolve the structure of these comple

73 tion about the population-specificity of the breakpoints and underlying amplification mechanisms.

74 in turn has led to the creation of clinical breakpoints and, more recently, epidemiological cutoff v

75 ased motivation (decreased progressive ratio breakpoint) and require a longer stimulus length to comp

76 and are equivalent to the 2009 CLSI M100-S19 breakpoints, and (ii) the 2014 CLSI M100-S24 breakpoints

77 .7%, and 95.5%, respectively, by the Vitek 2 breakpoints, and 93.4%, 92.3%, and 95.5%, respectively,

78 ccumulate focally, occur with multiple mixed breakpoints, and in the presence of normal mtDNA sequenc

79 evaluating clinical outcomes of the affected breakpoints, and it is unknown if patients infected with

80 mal drug exposures and doses, susceptibility breakpoints, and optimal combination regimens.

81 ates, the validity of currently accepted MIC breakpoints, and the erm(41) sequences associated with s

82 2 S. pseudintermedius oxacillin MIC and disk breakpoints, and the European Committee on Antimicrobial

83 Although gene breakpoints, and thus the total number of gene pieces (

84 , we established that avian interchromosomal breakpoints appear in the regions of low density of cons

85 The breakpoint appears to be fairly stable in the future, su

86 No clinical breakpoints are available to delineate antifungal drug e

87 ar features that define recurrent chromosome breakpoints are largely unknown.

88 ify a subset of genomic rearrangements whose breakpoints are located in or near exons.

89 We observed breakpoints are more likely to occur in regions enriched

90 ervations suggest that detected mosaic event breakpoints are preferentially recovered in genomic regi

91 Breakpoints are used to predict whether an antifungal ag

92 ted evolution of testing recommendations and breakpoints, are inevitable.

93 However, they decreased motivation in a breakpoint assay and did not promote reversal learning i

94 In contrast, breakpoints associated with non-homologous (NH) mechanis

95 The breakpoints associated with these rearrangements map to

96 align on a hydrological relationship with a breakpoint at 2000 mm annual precipitation, where the s

97 aled the existence of a single recombination breakpoint at the boundary of the non-structural and the

98 one sample, which contained a recombination breakpoint at the E2/P7 gene junction.

99 nant progenies and scanned for recombination breakpoints at approximately 1-kb intervals.

100 genomic sequencing data and pinpoints their breakpoints at single base-pair resolution.

101 k 2 breakpoints, which utilized the 2009 FDA breakpoints at the time of the study and are equivalent

102 We used the genomic breakpoint between BCR and ABL1 genes for the DNA-based

103 The recombination breakpoint between genotypes 2 and 1 was consistently lo

104 The translocation breakpoints between 1BS and alien chromatin fell in thre

105 is also clinically important to detect their breakpoint boundaries at high resolution.

106 validated 83% of 44 predicted transposition breakpoints by polymerase chain reaction.

107 econstruct gene fusion junctions and genomic breakpoints by split-read mapping.

108 We find that 34% of CNA breakpoints can be clarified structurally and that most

109 Analysis of the DNA sequence at SV breakpoints can reveal mutational mechanisms and risk fa

110 ror (VME) (0.05%) observed using the Vitek 2 breakpoints (cefazolin) and 8 VMEs (0.5%) using the CLSI

111 The breakpoint change improves the probability of pharmacody

112 treatment of two nitrifying facilities with breakpoint chlorination (BPC) temporarily suppressed nit

113 Here we show that the Rac1 GAP breakpoint cluster region (BCR) associates with NMDA rec

114 Importantly, we found that although breakpoint cluster region (BCR)-ABL1 kinase remained eff

115 sses the expression of the human gene called breakpoint cluster region (Bcr).

116 points, including the mixed-lineage leukemia breakpoint cluster region (MLL BCR).

117 humanized pan-CD44 monoclonal antibody and a breakpoint cluster region - ABL proto-oncogene 1, nonrec

118 test successes in the hematologic arena (eg, breakpoint cluster region [BCR]/Abelson [ABL] kinase inh

119 The most common breakpoint cluster region gene-Abelson murine leukemia v

120 microarray profiling analysis, we identified breakpoint cluster region mRNA (Bcr) as a cellular targe

121 tween LCR22A and LCR22D were enriched in the Breakpoint Cluster Region pseudogene (BCRP) block, sugge

122 ical domain borders, and frequently occur at breakpoint clusters commonly translocated in cancer.

123 The results revealed that most of the breakpoints converged in gp41 (62%) and C1 (25.3%) domai

124 rrangements, comprehensive interpretation of breakpoints could substantially improve prediction of ph

125 Sequence-level breakpoint data resolve SV structure and determine how g

126 By using chromosome breakpoint data, we established that avian interchromoso

127 Infection with both viruses resulted in breakpoint-dependent expression of EGFP-tk and ganciclov

128 Vs substantially improves the specificity of breakpoint detection at comparable sensitivity.

129 e-wise linear regression method was used for breakpoint detection in Rain-Use Efficiency (RUE) time s

130 The new breakpoints did little to the Enterobacteriaceae %S, but

131 On the other hand, the 5q translocation breakpoint disrupts the 3' UTR of MATR3, which encodes t

132 The 1p breakpoint disrupts the 5' UTR of AHDC1, which encodes A

133 ative output useful to inform susceptibility breakpoints, dosage, and optimal combination regimens in

134 R2 amplified rats' motivation, raising their breakpoint effort price for cocaine by 10-fold.

135 The disk and MIC breakpoints evaluated included the Clinical and Laborato

136 Clinical and Laboratory Standards Institute breakpoints exist to guide interpretation of minocycline

137 nt PCR and Sanger sequencing determined both breakpoints flanked by a 4-bp microhomology (CTTG).

138 By placing windows around the 272 breakpoints followed by Monte Carlo analysis comparing a

139 pofungin MICs of >/=0.5 mug/ml, the clinical breakpoint for caspofungin resistance in this species, m

140 einforcement, JWH133 significantly increased breakpoint for cocaine self-administration in rats, but

141 ggesting that modification in the daptomycin breakpoint for enterococci should be considered.

142 ates had MICs </= 16 mg/L (proposed clinical breakpoint for temocillin).

143 ata generated in this study support a single breakpoint for testing trimethoprim-sulfamethoxazole and

144 The segmented regression estimated a breakpoint for the time to tear at 182 days.

145 to minimize the delay in the adoption of new breakpoints for antimicrobials against emerging pathogen

146 Interestingly, breakpoints for atypical 22q11.2 rearrangements have pre

147 ratory Standards Institute-approved clinical breakpoints for Brachyspira species, to facilitate infor

148 LSI's recommendation to lower susceptibility breakpoints for carbapenems.

149 ratory Standards Institute (CLSI) carbapenem breakpoints for Enterobacteriaceae and the lack of activ

150 split-read approach to identify the precise breakpoints for indels of size less than a user specifie

151 recommend that clarithromycin susceptibility breakpoints for M. abscessus subsp. abscessus be changed

152 y Standards Institute (CLSI) lowered the MIC breakpoints for many beta-lactam antibiotics to enhance

153 y Standards Institute (CLSI) lowered the MIC breakpoints for meropenem and imipenem from 4 mg/liter t

154 supporting the elimination of staphylococcal breakpoints for other beta-lactam agents.

155 ptibility, determined using the revised CLSI breakpoints, for extended-spectrum-beta-lactamase (ESBL)

156 -frame fusion genes at sequenced duplication breakpoints; four gene fusions were formed by tandem dup

157 d from sequences immediately adjacent to the breakpoint from at least one-but sometimes both-chromoso

158 hole-genome sequencing (WGS) to sequence 130 breakpoints from 112 subjects with 119 CNVs and found th

159 functional and non-functional recombination breakpoints from either the FRP system or dual infection

160 and 46 from dog-human genomic rearrangement breakpoint (GRB) regions, as well as 38 passenger candid

161 We find breakpoints have more nearby SNPs and indels than the ge

162 get of fusion events, confirming its role as breakpoint hotspot in MYC amplification.

163 ences of oligonucleotides from a chromosomal breakpoint hotspot in the human c-MYC oncogene containin

164 -seq also identified RGN-independent genomic breakpoint 'hotspots'.

165 he MIC data were evaluated using two sets of breakpoints: (i) the Vitek 2 breakpoints, which utilized

166 Susceptibility breakpoints identified using these methods differed from

167 Refinement of microdeletion breakpoints identifies a subgroup of patients that map t

168 to 132 further samples identified the common breakpoint in all years tested (2003-2015), with a decli

169 The breakpoint in the mathematical model and the experimenta

170 A breakpoint in time to appropriate therapy was identified

171 We identify and analyse 8,943 deletion breakpoints in 1,092 samples from the 1000 Genomes Proje

172 enomic hybridization, we have identified the breakpoints in 85 unrelated individuals carrying an NF1

173 Intriguingly, the CNV breakpoints in all three genomes showed significantly bi

174 ing the response-outcome contingency rescued breakpoints in Bdnf(+/-)mice.

175 lisation of MYC-Immunoglobulin translocation breakpoints in Burkitt's lymphoma.

176 n and 46 365 sequence-characterized deletion breakpoints in cancer genomes, we find significant assoc

177 al of 44 patients, we confirmed that the CNV breakpoints in each patient map within the LINE elements

178 Remarkably, BCA breakpoints in eight subjects altered a single TAD encom

179 ates and identified the flanking sequence of breakpoints in heterochromatic regions.

180 so decreased elevated progressive-ratio (PR) breakpoints in rats in the LgA condition and continued t

181 mains challenging because many variants have breakpoints in repetitive regions of the genome and thus

182 T, positioning a super-enhancer close to the breakpoints in seven cases.

183 double counting, resulting in a total of 272 breakpoints in the data set.

184 on breakpoints were determined, yielding 272 breakpoints in the full data set.

185 rs somatic and germline structural variation breakpoints in whole-genome sequencing data.

186 eriaceae The decision to implement these new breakpoints, including the changes announced in both 201

187 late-replicating domains, fragile sites, and breakpoints, including the mixed-lineage leukemia breakp

188 Microhomology (TAA and AGCT) at the breakpoints indicated that microhomology-mediated FoSTeS

189 o translocations revealed at least 18 and 33 breakpoints involving five different chromosomes.

190 At least 11 validated clustered breakpoints involving intrachromosomal and interchromoso

191 and six rearrangements have more than three breakpoints involving two to five chromosomes.

192 ce the genomic distribution of rearrangement breakpoints is non-random, intrinsic cellular factors ma

193 rks, along with the lack of homology between breakpoint joins and the randomness of the order and ori

194 Notably, among the human CNVs with distinct breakpoint junction characteristics, the homology-mediat

195 andem duplications or complex gains, exhibit breakpoint junction features reminiscent of replicative

196 on of Alu-mediated rearrangement in CGRs and breakpoint junction sequences analysis further demonstra

197 array comparative genomic hybridization and breakpoint junction sequencing.

198 PCR) is a traditional approach to obtain CNV breakpoint junction, but this method is inefficient when

199 ns have inversions, insertions, and multiple breakpoint junctions between only two chromosomes.

200 All of these breakpoint junctions had 0-4 bp of microhomology consist

201 Analysis of breakpoint junctions implicates breaks followed by repai

202 ces often were identified at both reciprocal breakpoint junctions in six of eight other tumor types.

203 We report that breakpoint junctions indeed are enriched around TSSs tha

204 At the breakpoint junctions of these nonrecurrent rearrangement

205 Sequencing 37 breakpoint junctions revealed that simple translocations

206 Remarkably, 29 (94%) of the 31 CNV breakpoint junctions unobtainable by conventional long-r

207 approximately 150 bp per probe density; CNV breakpoint junctions were mapped to nucleotide resolutio

208 enous loci followed by the identification of breakpoint junctions within a population, which typicall

209 rtions and microhomologies were found at the breakpoint junctions, suggesting potential replicative m

210 s rarely, if ever, had large duplications at breakpoint junctions.

211 ntical sequences adjacent to both reciprocal breakpoint junctions.

212 ism was a major contributor for formation of breakpoint junctions.

213 nly similar partner genes but also identical breakpoints leading to oncogene overexpression.

214 ic consequences of duplication CNVs requires breakpoint-level analysis.

215 nd complex structural variants with multiple breakpoints likely to have formed through individual mut

216 s circulating in Hipposideros bats, with the breakpoint located near 5' and 3' ends of the spike (S)

217 mtDNA deletions are major arc deletions with breakpoints located between the origin of light strand (

218 Seeksv develops a rescue model for SV with breakpoints located in sequence homology regions.

219 nd amplified AR and display heterogeneity in breakpoint location, rearrangement class and sub-clonal

220 tent with these data, we observe chromosomal breakpoint locations are biased away from H3K36me3 sites

221 Breakpoint mapping revealed transection of SIPA1L3 at 19

222 block, providing a starting point for future breakpoint mapping using additional trios.

223 ever, even for a specific rearrangement, the breakpoints may vary between individuals, such as the re

224 arbapenem-resistant Enterobacteriaceae (CRE) breakpoints might have resulted in 1,821 additional carr

225 nation allowing for intracodon recombination breakpoints, molecular adaptation and codon substitution

226 22A and LCR22D and a potential recombination breakpoint near or within the BCRP block, providing a st

227 Translocation breakpoints near PONDS-forming repeats also recur in dif

228 Breakpoints occurring in the terminal inverted repeats w

229 t extinction risk changes around a body mass breakpoint of 0.035 kg, indicating that the lightest and

230 do not confer resistance at a susceptibility breakpoint of 100 mug/ml pyrazinamide in MGIT within a c

231 of NKX3.1 favors recruitment to the ERG gene breakpoint of proteins that promote error-prone nonhomol

232 One breakpoint of the inversion disrupts the essential CENP-

233 We analyzed the breakpoints of 57 unique unbalanced translocations to in

234 tions ("paired duplications") that flank the breakpoints of an inversion.

235 , our method predicted the number, type, and breakpoints of biologically validated SVs at high accura

236 derstand the genetic-epigenetic interplay at breakpoints of chromosomal translocations disrupting CG-

237 that the density of SNPs/indels flanking the breakpoints of deletions (in-phase variants) is approxim

238 s non-TTAGGG nucleotide insertions at fusion breakpoints of dysfunctional telomeres.

239 roach to both detecting and interpreting the breakpoints of structural rearrangements yields unparall

240 Specifically, we targeted the breakpoints of TMEM135-CCDC67 and MAN2A1-FER fusions in

241 l patterns of copy number variation flanking breakpoints of translocations.

242 We demonstrate that the breakpoint on the X chromosome disrupted a gene that enc

243 CSReport identifies junction segment breakpoints on reference sequences and junction structur

244 parative genomic hybridization (aCGH) and/or breakpoint PCR and 64 were confirmed.

245 Split-read analysis of WES data followed by breakpoint PCR and Sanger sequencing determined both bre

246 performed two existing algorithms on precise breakpoint prediction, which is clinically important.

247 tural variants by merging structural variant breakpoint predictions, gene exon structure, read depth,

248 fied in new susceptible dose-dependent (SDD) breakpoints promulgated by the Clinical and Laboratory S

249 changes were accompanied by modifications in breakpoint ratios in a progressive ratio task, and they

250 of an MAP kinase kinase inhibitor increased breakpoint ratios, whereas the addition of discrete cues

251 egrity, we analyzed anomalous read pairs and breakpoint reads throughout the euchromatic genome.

252 somal breakpoints reveals 2 distinct cluster breakpoint regions (CBRs) within either CD274 (CBR1) or

253 ations in the anaplastic large cell lymphoma breakpoint regions of NPM1 and ALK.

254 V-diversifies through both recombination and breakpoint repair, while concerted evolution of IR1 is d

255 and how implementation of these updated CLSI breakpoints requires partnership between antimicrobial s

256 ich frequently showed microhomology near the breakpoints resembling repair by non-homologous end join

257 With the new breakpoints, resistance was significantly increased for

258 with dynamic programming is used to improve breakpoint resolution.

259 oreover, analysis of the precise chromosomal breakpoints reveals 2 distinct cluster breakpoint region

260 0.5 mug/ml, 4-fold below the susceptibility breakpoint (S </= 2 mug/ml).

261 Breakpoint sequence analyses showed nonrecurrent deletio

262 l seven lines the exact integration site and breakpoint sequences were identified.

263 kase Cas9(D10A) and guide RNAs targeting the breakpoint sequences, and another to deliver an EGFP-HSV

264 approaches (especially ALN-walking) for CNV breakpoint sequencing and highlights their importance in

265 Recent improvements in breakpoint sequencing have also revealed non-allelic hom

266 ed nested PCR walking' (ALN-walking) for CNV breakpoint sequencing in 49 subjects with PMD-associated

267 Breakpoint sequencing of one maternally inherited transl

268 Breakpoint sequencing of our large collection of chromos

269 resolved by aCGH, were revealed by efficient breakpoint sequencing.

270 o performs sequence assembly across multiple breakpoints simultaneously, enabling the reconstruction

271 Through breakpoint-spanning PCR as well as array comparative gen

272 A novel breakpoint-specific polymerase chain reaction assay was

273 Large-scale SV breakpoint studies have become possible recently owing t

274 observed in the absence of direct intragenic breakpoints, suggesting a requirement for sustaining onc

275 BreakPoint Surveyor (BPS) is a computational pipeline fo

276 he human reference, identifying thousands of breakpoints that, to our knowledge, have not been report

277 oxacillin MIC breakpoint and cefoxitin disk breakpoint, the CLSI VET01-S2 S. pseudintermedius oxacil

278 n MIC breakpoints and cefoxitin disk and MIC breakpoints, the CLSI M100-S25 coagulase-negative Staphy

279 egions in the proximity of sequence assembly breakpoints, the majority of which contained complex arr

280 eliminated impulsive action and returned PR breakpoint to low-drive levels.

281 les, with the potential to define chromosome breakpoints to bp resolution.

282 We mapped the locations of FM7 breakpoints to precise euchromatic coordinates and ident

283 Two key studies on this point mapped breakpoints to sites of either convergent or divergent t

284 by identifying misassembly errors and their breakpoints using paired-end sequence reads and optical

285 The mean drug breakpoint value was also significantly lower in the act

286 However, a breakpoint was detected with a significant decreasing sl

287 ygen; and the change in QY at the Kok effect breakpoint was unaffected by oxygen.

288 ammonium was removed (i.e., the chlorination breakpoint) was a promising method to minimize byproduct

289 MICs falsely elevated above the resistance breakpoint were also not observed for C. tropicalis isol

290 llumina sequencing system, and recombination breakpoints were determined for each of the recombinants

291 Recombination breakpoints were determined, yielding 272 breakpoints in

292 ing PCR analysis, we infer that the deletion breakpoints were most likely located near or within the

293 Recombination breakpoints were partitioned into intragenic and interge

294 e the most frequent repeats at translocation breakpoints, whereas A-tracts occur preferentially at de

295 ing two sets of breakpoints: (i) the Vitek 2 breakpoints, which utilized the 2009 FDA breakpoints at

296 ently updated CLSI and EUCAST susceptibility breakpoints will help to optimize clinical outcomes and

297 plit alignment strategy that can identify SV breakpoints with base pair resolution.

298 By investigating the correlation of breakpoints with DNA methylation, Hi-C interactions, and

299 nvolving four chromosomes uncovered multiple breakpoints with inversions and insertions.

300 terns of nucleotides near them, we find that breakpoints with the signature of non-allelic homologous