ライフサイエンスコーパス: breakthrough

1 , conductive channels form, leading to fluid breakthrough.

2 d nonpolar peptides alike without noticeable breakthrough.

3 sorption temperature, which prevents analyte breakthrough.

4 ical industry, the field is poised to make a breakthrough.

5 cirrhotic CHB patients without a virological breakthrough.

6 oth of them are conducive to the fill-factor breakthrough.

7 4 relapses (2 per group) and no virological breakthroughs.

8 ial, holding great promise for future market breakthroughs.

9 envision PAT's potential to lead to further breakthroughs.

10 regulatory challenges of future reproductive breakthroughs.

11 n which amyloid-based structures promise new breakthroughs.

12 rt x-ray pulses that led to major scientific breakthroughs across disciplines from matter to material

13 for single-arm trials aiming to demonstrate breakthrough activity of a single-agent anticancer thera

14 transcriptional signature of T cells during breakthrough acute graft-versus-host disease (GVHD) that

15 identify 3 key transcriptional hallmarks of breakthrough acute GVHD that are not observed in hyperac

16 Breakthrough advancement in boiling and quenching phase-

17 This paper reports breakthrough advancements on both fronts of boiling and

18 r further systems-based efforts to study the breakthrough alloresponse that occurs posttransplant des

19 ue of recombinant PEDV viruses in vitro This breakthrough allows us to investigate other virulence de

20 ow QRS patients demonstrated (1) multiple LV breakthroughs along the posterior or anterior fascicles:

21 These breakthroughs also raise complex legal issues for patien

22 Among these agents, daratumumab is clearly a breakthrough and daratumumab-based combinations might be

23 dwater responses to contamination: (1) rapid breakthrough and flushing of synthetic NO3(-) (low delta

24 in the 12-week group experienced virological breakthrough and one discontinued prematurely after the

25 This work can be a breakthrough and provide a new perspective for the modif

26 ues positively correlates with tumor capsule breakthrough and vascular invasion.

27 ciency of different membranes, and highlight breakthroughs and key challenges in this field.

28 We seek to piece together early breakthroughs and key developments, and highlight and di

29 Here, we review the key breakthroughs and remaining obstacles to the development

30 citement, the promise of subsequent research breakthroughs and the high prestige then associated with

31 onsent, 2 had confirmed virologic relapse or breakthrough, and 2 patients had clinical history and ph

32 air gene MSH2 exhibit a higher propensity to breakthrough antifungal treatment in vitro and in mouse

33 f passive fluid flow control, with potential breakthrough applications in advancing manufacturing, bi

34 and the opportunities for further scientific breakthrough are numerous--but so are the challenges.

35 Methodological breakthroughs are accelerating knowledge of the processe

36 o the multiplex arena, several technological breakthroughs are emerging with novel solutions that fur

37 ernutrition, both research and technological breakthroughs are needed.

38 T wave provides novel insights into risk of breakthrough arrhythmic events in LQTS, particularly LQT

39 ients typically demonstrated (1) a single LV breakthrough at the septum (38+/-15 ms post-QRS onset);

40 performance stability that provides the true breakthrough: at 1000 cd/m(2) the efficiencies were stil

41 tions had little to no effect on MIB and WFN breakthrough behavior.

42 B virus (HBV) therapies are expected to have breakthrough benefit for patients.

43 The Nobel Committee has recognized this breakthrough by the awarding of the 2016 Nobel Prize in

44 enty-three patients experienced >/=1 defined breakthrough cardiac arrhythmic events with 5- and 10-ye

45 Breakthrough cardiac events (BCEs) were defined as LQTS-

46 hich translates to real separations in a gas breakthrough column.

47 Here we briefly recount the early breakthroughs concerning the asymmetric hydrogenation of

48 and phenotypic characterization of 15 viral breakthroughs considered to be virological failures.

49 en selected by NAR reviewers and editors as 'breakthrough' contributions, denovo-db, the Monarch Init

50 higher than the influent through much of the breakthrough curve (GAC does not remove bromide), which

51 stigated over 8 months in the tailing of the breakthrough curve of run 13-05 as well as in samples co

52 ene mixtures is demonstrated by experimental breakthrough curves (0.73 millimoles per gram from a 1/9

53 Concentration breakthrough curves (BTC) of BAM and ibuprofen demonstra

54 AgNP concentrations for breakthrough curves (BTCs) and retention profiles (RPs)

55 isotherms, simulated and experimental column breakthrough curves and molecular simulation studies col

56 eatment efficacy, this work paired predicted breakthrough curves determined by the homogeneous surfac

57 Experimental breakthrough curves further demonstrate the excellent pe

58 Breakthrough curves obtained from experiments conducted

59 Column breakthrough curves were always well described using an

60 ade C2 H4 ), as demonstrated by experimental breakthrough curves.

61 991) is a newly developed drug that received breakthrough designation and recent US Food and Drug Adm

62 Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes

63 Major breakthroughs during the past decade, especially in isot

64 This breakthrough ensures, for the first time, the applicabil

65 The main reasons for a breakthrough event are underlying disease and subtherape

66 anagement of further anticoagulation after a breakthrough event is based on minimal or no clinical tr

67 In addition, thermogravimetric analysis and breakthrough experiments indicate that, in contrast to m

68 Breakthrough experiments show that 1 only loses 7% of it

69 Cyclic CO2/N2 mixed-gas column breakthrough experiments under dry and humid conditions

70 Breakthrough extensively drug-resistant A. baumannii bac

71 orld is becoming a better place, in part, by breakthrough findings by scientists.

72 A clinical breakthrough followed in 2011 with (68)Ga-PSMA-11 for PE

73 w imaging method could potentially provide a breakthrough for numerous practical imaging applications

74 The established technology displays a breakthrough for quantitative high-throughput plant meta

75 laherparepvec in advanced melanoma, a major breakthrough for the field.

76 This knowledge provides a potential breakthrough for the prevention of intellectual disabili

77 r technology and bioinformatics have enabled breakthroughs for other complex traits, such as cardiova

78 ional design of NEs and recent technological breakthroughs for the development of a new generation of

79 In the drug delivery field, many breakthrough formulations have been achieved helping pat

80 atients in the prophylaxis group developed a breakthrough fungal infection.

81 NA samples from participants in the UK-based Breakthrough Generations Study.

82 A recent breakthrough has been the discovery of the myosin activa

83 While significant medical breakthroughs have been achieved through using animal mo

84 Major breakthroughs have been made dissecting the molecular ba

85 Breakthroughs have been made in algorithmic approaches t

86 nding astrophysical mystery, although recent breakthroughs have come from models invoking the turbule

87 A number of recent breakthroughs have dramatically advanced our understandi

88 Essentially, technological breakthroughs have enabled researchers to probe an indiv

89 Remarkable breakthroughs have established the functionality of grap

90 Recent experimental breakthroughs have finally allowed to implement in-vitro

91 While these breakthroughs have led to a steady expansion of the chla

92 As we discuss here, these breakthroughs have led to an ongoing surge in the develo

93 Recent technological breakthroughs have made it possible to measure RNA expre

94 These breakthroughs have stimulated further design and stabili

95 No participant had evidence of breakthrough HBV infection.

96 We provide breakthrough in addressing these problems by developing

97 991, the world awoke to front-page news of a breakthrough in biological research.

98 molar concentrations in biofluids would be a breakthrough in diagnostics and therapeutics.

99 lectrochemically surface area (ECSA) and the breakthrough in electrochemical quantification of the Pt

100 rogress in crystallographic methods led to a breakthrough in elucidating the structures of membrane p

101 electric solid solution single crystals is a breakthrough in ferroelectric materials.

102 Here, a fundamental breakthrough in generating high-quality conjugated-polym

103 vage by protein engineering, ushering in the breakthrough in genome manipulation.

104 eve this rapid, low-cost method represents a breakthrough in intraoperative margin assessment during

105 SbTe, which is crucial for its technological breakthrough in memory devices.

106 y by Tan and colleagues provides an exciting breakthrough in our ability to study the neural mechanis

107 halide perovskites have triggered the latest breakthrough in photovoltaic technology.

108 excitations in electronic systems is a major breakthrough in recent condensed matter physics, finding

109 y removable burn wound dressing represents a breakthrough in second-degree burn wound care.

110 epidermal growth factor receptor (EGFR) is a breakthrough in targeted cancer therapy and marks a dras

111 The last five years have witnessed a huge breakthrough in the creation and the study of the proper

112 A breakthrough in the development of 4D scanning ultrafast

113 OCT has been a technological breakthrough in the diagnosis, treatment, and follow-up

114 The recent breakthrough in the discovery of Weyl fermions in monopn

115 gue performance reported in this paper are a breakthrough in the field of low-cost titanium processin

116 wide range of pump power values, heralding a breakthrough in the non-invasive analysis of fiber laser

117 to organic NH4(+), thus represented a major breakthrough in the radiation of life, but its timing is

118 We take advantage of a recent breakthrough in the synthesis of alpha,beta-unfunctional

119 a' for reaching the long expected conceptual breakthrough in this domain.

120 lent tissue compatibility represents a major breakthrough in this field and a promising alternative t

121 This study represents a major breakthrough in understanding the biology of CyHV-3 and

122 One recent breakthrough in understanding the molecular interplay be

123 Furthermore, our results serve as a breakthrough in understanding the potential mechanism un

124 discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding

125 of the scientific production, and fostering breakthroughs in a shorter time.

126 Recent scientific breakthroughs in an initial study of the thanatomicrobio

127 The recent breakthroughs in assembling long error-prone reads were

128 Over the past 3 years, numerous breakthroughs in basic science and clinical research hav

129 l experimentations have spearheaded numerous breakthroughs in biomedicine, they also have spawned man

130 progress in high-speed computing depends on breakthroughs in both materials synthesis and device arc

131 ease have yet to be fully elucidated, recent breakthroughs in clinical trials have demonstrated that

132 cular response may then contribute to future breakthroughs in dental medicine.

133 medical applications, and are now informing breakthroughs in diverse frontiers of science and engine

134 This minireview discusses recent breakthroughs in elucidating the substrates and cellular

135 In this Series paper, we review scientific breakthroughs in epidemiology, genetics, and molecular b

136 We briefly recount the breakthroughs in functionalized and unfunctionalized tet

137 Technological breakthroughs in genomics, in particular large-scale seq

138 Recent breakthroughs in high-resolution nanofabrication utilizi

139 ntial to drive next-generation technological breakthroughs in holography.

140 ens, these developments provided significant breakthroughs in infectious diseases.

141 Recent breakthroughs in isotope-labeling and pulse sequence tec

142 new therapies for diabetic retinopathy, and breakthroughs in laboratory production of beta-cells.

143 Recent breakthroughs in molecular biology and next generation s

144 The advances have accompanied the breakthroughs in molecular biology, nanomaterial science

145 Recent breakthroughs in next-generation sequencing technologies

146 Recent breakthroughs in next-generation sequencing technology a

147 to treat leukemia with the hope that further breakthroughs in NK cell biology can extend treatments t

148 Recent breakthroughs in novel immune-related treatment strategi

149 quantum states of light can precipitate many breakthroughs in observing and controlling light-matter

150 Breakthroughs in our global fight against cancer have be

151 ies in the last decade have made fundamental breakthroughs in our understanding of how cellular effec

152 ancient peoples have facilitated a number of breakthroughs in our understanding of human evolutionary

153 eract in living cells, setting the stage for breakthroughs in our understanding of RNA structure and

154 Mouse models have enabled breakthroughs in our understanding of the immune system,

155 mics and RNA interference (RNAi) have led to breakthroughs in our understanding of the mechanisms of

156 Recent breakthroughs in pluripotent stem cell technologies have

157 Deep convolutional nets have brought about breakthroughs in processing images, video, speech and au

158 Recent clinical breakthroughs in recombinant adeno-associated viral vect

159 contain lead(ii) and thallium(i) but recent breakthroughs in regard to the preparation of low oxidat

160 In addition, breakthroughs in reprogramming strategies have enabled t

161 we will highlight the most important recent breakthroughs in selective allylboron chemistry (both th

162 First, breakthroughs in sequencing technology and reduced cost

163 During the past decade, with its breakthroughs in systems biology, precision medicine (PM

164 id biopsies of disease is being bolstered by breakthroughs in the analysis of circulating tumor DNA (

165 These findings represent important breakthroughs in the deorphanization of codling moth phe

166 Given recent breakthroughs in the development of CRISPR-Cas9 reagents

167 We review important challenges and breakthroughs in the field as a comprehensive practical

168 This interplay has allowed some important breakthroughs in the field of organolanthanide chemistry

169 ric version, forecast the development of new breakthroughs in the synthetically valuable field of dia

170 computational approaches have led to recent breakthroughs in the use of microbiome approaches for fo

171 In this Perspective, we overview the major breakthroughs in this field, highlighting the recent adv

172 ives an update on the latest discoveries and breakthroughs in this field, with an emphasis on structu

173 Breakthroughs in understanding of the biology of the tra

174 This review highlights recent breakthroughs in understanding the key causes of these a

175 these are partially considered as possible 'breakthrough' in the treatment of AD.

176 Recent theoretical breakthroughs include the characterisation of the effici

177 The field appears poised for breakthroughs, including the exciting prospect of resolv

178 Serological breakthrough infection (7106 mIU/mL) was documented in 1

179 However, a single mouse experienced breakthrough infection after 63 days when the serum HMAb

180 red in 13 patients (4%), including 1 case of breakthrough infection and 12 relapses, and was associat

181 methods and tools applicable to analysis of breakthrough infection genomes in general vaccine effica

182 Interestingly, RMs experiencing breakthrough infection showed significantly higher prech

183 investigated through sieve analysis of HIV-1 breakthrough infections (infected vaccine and placebo re

184 acute seronegative HIV infection and in PrEP breakthrough infections and that FTC is associated with

185 of the first complete-genome analysis of the breakthrough infections in the RV144 trial, this work de

186 Breakthrough infections underline the importance of earl

187 No increase in breakthrough infections with antibiotic-resistant organi

188 However, breakthrough infections with fungal pathogen Aspergillus

189 Breakthrough infections, usually after incomplete RV vac

190 pose to higher acute viremia in the event of breakthrough infections.

191 -/-) mice, a subset of TRIF(-/-) mice showed breakthrough inflammation and the ability to induce thes

192 No region achieved the 50% Fistula First Breakthrough Initiative (now known as Fistula First Cath

193 Recent breakthroughs introduced a description of open dissipati

194 Breakthrough invasive mold infections (IMIs) that occur

195 Such a breakthrough is achieved by considering both prior biolo

196 A major methodological breakthrough is described that couples the high brillian

197 leukemogenesis could represent a therapeutic breakthrough, leading to complete remission and overcomi

198 These breakthroughs led to the identification of the key struc

199 f cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiolog

200 ed abnormal and varied epicardial activation breakthrough locations and regions of nonuniform conduct

201 ological T-wave analysis program in defining breakthrough LQTS arrhythmic risk beyond the QTc value.

202 Breakthrough measurements further indicate that Co2(m-do

203 We envisage our approach to be a breakthrough method for synthesizing complex functionali

204 stigated with experimental and computational breakthrough methods.

205 risk antineoplastic agents or who experience breakthrough nausea and vomiting; a recommendation to ad

206 aling and ultimately democratizing access to breakthrough neurotechnologies, and (2) commercializing

207 relapse, and one (2%) of 44 had virological breakthrough; no virological failures were recorded in t

208 by previous treatment category (relapser or breakthrough, non-responder, or interferon-intolerant) f

209 The presence of colloids promotes the breakthrough of ciprofloxacin (over 90% sorbed on colloi

210 to fouling, performance decline and possible breakthrough of contaminants.

211 DBPs, and the SOS genotoxicity followed the breakthrough of dissolved organic carbon (DOC), however

212 Two sampling artifacts were observed: breakthrough of high-volume sampler filters for penta- a

213 Despite the breakthrough of over 22% power conversion efficiency dem

214 ious particles and the uranine dye, with the breakthrough of particles occurring slightly earlier tha

215 in oxic groundwater; (2) delayed and reduced breakthrough of synthetic NO3(-) subjected to partial de

216 led to protect seronegative individuals from breakthrough or enhanced dengue infections suggest that

217 No breakthrough or relapse occurred in the W28 arm, resulti

218 c stress, not just enrichment; (3) achieving breakthrough outcomes for young children facing adversit

219 In a conceptual breakthrough over 80 years old, Cerenkov showed how char

220 al limit, and there have been no significant breakthrough over the last decade.

221 Methodological breakthroughs over the past four decades have repeatedly

222 ovel preclinical measure of movement-induced breakthrough pain (BTP) that is observed in the presence

223 pain is well controlled, patients can suffer breakthrough pain (BTP), episodic severe pain that "brea

224 here were differences in mood (P = .031) and breakthrough pain duration (P = .037) between arms.

225 ge pain, interference of pain with activity, breakthrough pain, mood, quality of life, and adverse ev

226 These breakthroughs pave the route for the study of a series o

227 The breakthrough phase (final jump) was imaged for 2 events.

228 The current at the end of the breakthrough phase, lasting on average 4.7 mus, was esti

229 This class of semiconductor might empower breakthrough photodetector technology in the field of im

230 models of North Sea chalk, we show that the breakthrough porosity is an important indicator of disso

231 ective channels known as wormholes, with low breakthrough porosity.

232 porous media homogeneously, leading to large breakthrough porosity.

233 lar analysis of biological samples and has a breakthrough potential for dissection of cellular molecu

234 Using strict criteria for breakthrough (presence of an opposite wave within 4 mm a

235 Breakthrough profiles assessed using the AM only showed

236 l of sampling, however, is possible with the breakthrough protein energy landscape exploration techni

237 lapse (chi21 =11.1; P = .003) and control of breakthrough psychotic symptoms (beta = 0.2; t79 = 2.1;

238 Psychotic relapse and control of breakthrough psychotic symptoms.

239 Results The breakthrough reaction rate for 5-hour intravenous prophy

240 or no more than a clinically negligible 6.0% breakthrough reaction rate in the cohort that received 5

241 ng 5 hours before contrast-enhanced CT has a breakthrough reaction rate noninferior to that of a 13-h

242 Purpose To determine if the allergic-like breakthrough reaction rate of intravenous corticosteroid

243 The breakthrough reaction rate was compared by using the Far

244 actions despite the use of premedication (a "breakthrough reaction"), and the frequency of delayed re

245 In patients who experience a reaction, breakthrough reactions and delayed reactions are relativ

246 A total of 12 of 33 (36.4%) breakthrough reactions occurred, and there were 15 of 96

247 All breakthrough reactions were of equal or lesser severity

248 shes latency and reactivates frequently, and breakthrough reactivation can occur despite suppressive

249 nt promotes adaptation, which contributes to breakthrough resistance.

250 ible directions to be pursued that may yield breakthrough results, and envision the exciting potentia

251 ther, we were unable to identify any vaccine breakthrough signatures.

252 All wave fronts emanated from foci and breakthrough sites, and largely either collided or merge

253 poses an important bottleneck for developing breakthrough solutions.

254 The authors reporting this methodical breakthrough speculated that SCNT would allow the creati

255 ory of perovskites is being written with the breakthrough success of metal halide perovskites (MHPs)

256 n this arena continues through technological breakthroughs such as multiplexing: the detection of mor

257 These breakthroughs suggest a role for molecular doping not on

258 Breakthrough T/F Env pseudoviruses were potently neutral

259 nisms of cell function regulation has led to breakthrough targeted treatment advances for many diseas

260 These unique characteristics could enable breakthrough technologies for thermal transport control

261 Breakthrough tests show that the MOF-functionalized fibe

262 esistance in the vaccine compared to control breakthrough TF viruses when tested with plasma from vac

263 ndependent component analysis is a potential breakthrough that can inform ways in which prediction mo

264 covery of layered zeolites was a fundamental breakthrough that created unprecedented opportunities be

265 y direct-ink-write is a recent technological breakthrough that enables the creation of versatile comp

266 romyces cerevisiae, provided the key initial breakthrough that led to an explosion of research on the

267 directly or indirectly combating cancer is a breakthrough that seems likely to finally make successfu

268 r diagnosis, has seen significant scientific breakthroughs that allow adults and children undergoing

269 urage the crowdsourcing of open data to make breakthroughs that are of biomedical significance; secon

270 Alongside the technological breakthroughs that have facilitated the large-scale gene

271 Here, we summarize breakthroughs that instead indicate that astrocytes repr

272 ans should be aware of expanding use of this breakthrough therapy and implications for critical care

273 Yet, despite many breakthroughs, there are limitations to 'substrate-speci

274 all experiments, the difference between the breakthrough time (t5%) and the settling time of the qua

275 e microwave sensor was used to determine the breakthrough time and adsorption capacity of adsorbents/

276 ncontact sensor can be used to determine the breakthrough time and adsorption capacity.

277 Those parameters were related to adsorption breakthrough time and capacity.

278 e basis of the bromide (conservative tracer) breakthrough time at the port.

279 age, cumulative oil/gas productions, and CO2 breakthrough time.

280 nogen, DEKnull-2, provides an immunogenicity breakthrough to conserved protective epitopes.

281 In order for such breakthroughs to be discovered, researchers require syst

282 view, we introduce the field, from its early breakthroughs to its current results and future challeng

283 The present method allowed, as a breakthrough, to combine genetic, phenotypic and metabol

284 a residue that has also been associated with breakthrough transmission in the RV144 vaccine trial.

285 We found that breakthrough viruses able to establish infection in vacc

286 -targeted comparison of the genomes of HIV-1 breakthrough viruses identified two V2 amino acid sites

287 , when assessed for the 13 odorants at a 10% breakthrough volume (BTV), was 22.6 +/- 42.3, 0.70 +/- 1

288 ype, concentration and volume of the eluent, breakthrough volume, and effect of other ions were studi

289 d volume of elution and extraction solvents, breakthrough volume, salt addition, extraction time were

290 veraged 80% (range, 72.0%-95.1%), and (68)Ge breakthrough was less than 0.006%, initially decreasing

291 enced patients, respectively; no virological breakthrough was observed, and >/=99% of patients had a

292 Epicardial breakthrough waves (EBW) during atrial fibrillation are

293 =71) of EBW, as opposed to 21% of sinus node breakthrough waves (N=5; P<0.001).

294 EBW were referred to as sinus node breakthrough waves if they were the earliest right atria

295 A total of 218 EBW and 57 sinus node breakthrough waves were observed in 168 patients (44%).

296 Recent technological breakthroughs, which have led to the manufacture of expe

297 Three sets of breakthroughs will accelerate discoveries in the pathoge

298 is comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift

299 This result allows foreseeing a guaranteed breakthrough with regard to the use of the biosensor in

300 Using the breakthrough with unfractionated DOM as a baseline, on a