ライフサイエンスコーパス: bright

1 Excitation to the bright (1)pipi* or dark (1)npi* excited states does not

2 The resulting biocompatible, bright 1550 nm emitting nanoparticles enable fast in viv

3 osting down-conversion by 9-fold to produce bright 1550 nm luminescence under 980 nm excitation.

4 s bone marrow-derived aldehyde dehydrogenase bright (ALDHbr) cells in patients with peripheral artery

5 ature and characterized by the production of bright and colourful colonies.

6 onstrate optically induced switching between bright and dark charged divacancy defects in 4H-SiC.

7 arrow K') electron-electron scattering mixes bright and dark states of these complexes, and estimate

8 tional optical charge conversion between the bright and dark states of these defects.

9 Bright and efficient upconversion was measured for both

10 r is a white dwarf, and which often generate bright and energetic stellar outbursts.

11 synthetic chemistry and biochemistry enables bright and fast voltage imaging from genetically defined

12 challenging, as it requires dense labeling, bright and highly photostable dyes, and non-toxic condit

13 Ps and will facilitate future engineering of bright and low-blinking variants suitable for PALM.

14 Recently, bright and photostable single photon emitters were repor

15 l for the function of cone photoreceptors in bright and rapidly-changing light conditions.

16 ore difficult cognitive tasks were better in bright and self-selected lighting than in dim light for

17 ganic solvents, colloidally stable, and show bright and size dependent photoluminescence (PL).

18 We report three bright and spectrally distinct monomeric NIR FPs, termed

19 To create bright and stable fluorescent biolabels for immunoassay

20 c manipulations have created a vast array of bright and stable FPs spanning blue to red spectral regi

21 s, with only cubic nanocrystals sufficiently bright and stable to be observed as single emitters.

22 fficient rate to make it electromagnetically bright and therefore, contrary to expectations, is gas-s

23 ction of IFN-gamma and degranulation by CD56(bright) and CD56(dim) NK cells following NKG2D stimulati

24 ells is based primarily on conventional CD56(bright) and CD56(dim) NK cells from blood.

25 eciated that two major NK cell subsets (CD56(bright) and CD56(dim)) exist in humans and have distinct

26 We evaluated the role of CD4(dim)CD8(bright) and CD8 single positive T cells in HIV-infected

27 NKG2C(bright) and FcRgamma(-) NK cells coincided in a subgroup

28 dic geometry and are usually associated with bright angle-dependent hues.

29 OCT imaging identified this druse as a focal bright area.

30 ark, desiccated surface punctuated by small, bright areas.

31 he enamel (internal cracks) were observed as bright areas.

32 Y-FAST is as bright as common fluorescent proteins, exhibits good pho

33 cytometry experiments the NPs were twice as bright as two commercial anti-EpCAM red fluorophore conj

34 ogenous chromophore reduces rod responses at bright background.

35 At bright backgrounds, narrowband coherence allows pooling

36 T1-bright basal ganglia were confined to LGI1-IgG-positive

37 corresponding mutants of NanoLuc that enable bright bioluminescence.

38 of rod photoresponses following exposure to bright bleaching light.

39 ts bound to Cys in the GAF are the origin of bright blue-shifted fluorescence.

40 hierarchical ridge structures that produce a bright, blue reflection that remains stable across wide

41 The future for these enzymes is bright, but a renewed focus on studying them will be cri

42 Between the self-selected and the bright, but not the dim lighting condition, the onset of

43 , but not in NK-cell progenitors, CD3(-)CD56(bright), canonical, or adaptive CD3(-)CD56(dim) NK cells

44 uclear hypersegmentation, a CD62L(dim), CD16(bright), CD11b(bright), CD66b(bright), CD63(bright) surf

45 vided into functionally distinct CD3(-) CD56(bright) CD16(-) and CD3(-) CD56(dim) CD16(+) subsets.

46 ung consisted predominantly of immature CD56(bright)CD16(-) NK cells and less differentiated CD56(dim

47 In particular, CD56(bright)CD16(-/dim) NK cells are the focus of interest.

48 ad an immature phenotype (predominantly CD56(bright)CD16-CD57-), and expressed the tissue-residency m

49 in the bloodstream for a longer time (CXCR4(bright)CD5(dim) cells).

50 0 and variable CD58 for NLPHL; minimal CD50, bright CD58 expression for CHL).

51 62L(dim), CD16(bright), CD11b(bright), CD66b(bright), CD63(bright) surface phenotype, proinflammatory

52 mentation, a CD62L(dim), CD16(bright), CD11b(bright), CD66b(bright), CD63(bright) surface phenotype,

53 The polarization of emissions from a bright celestial X-ray source, the Crab, is reported her

54 Intermittent Claudication Injected With ALDH Bright Cells) is a National Heart, Lung, and Blood Insti

55 ontological relationship between human CD56(bright) cells and mouse CD127(+) ILC, or conserved netwo

56 considered more cytotoxic, whereas the CD56(bright) cells are potent producers of IFN-gamma.

57 CD56(bright) cells expressed high levels of the glucose uptak

58 CD56(bright) cells show preferential expression of ILC-associ

59 Interestingly, we found that CD56(bright) cells were more metabolically active compared wi

60 significantly over-represented in human CD56(bright) cells, by gene set enrichment analysis.

61 nd ZEB1 transcript levels are higher in CD56(bright) cells, while IKZF3 (AIOLOS), TBX21 (T-bet), NFIL

62 ined for the bright to dark than the dark to bright changes.

63 aves, forming extremely localized sources of bright coherent emission.

64 ing longer-lasting coloration and suggesting bright color traits may have an overlooked role in the v

65 The signal could be visual, such as bright coloration or some stereotypical movement that at

66 nting for more than 60%, responsible for the bright colour of the flesh of ripe fruits.

67 numerical results indicate the appearance of bright, dark and grey solitons dwelling in the vicinity

68 eaching yield, and, crucially, management of bright/dark state transitions, to optimize image resolut

69 ts Co-C bond at 100 degrees C, was stable in bright daylight, and also remained intact upon prolonged

70 facilitates detection of spatial details on bright days and large dim objects on moonless nights.

71 (4-amino-3-hydroxyphenyl)squaraine core with bright deep-red fluorescence and excellent photostabilit

72 there be light: Chemiluminescence provides a bright detection signal against a dark background and of

73 electron-positron plasma responsible for the bright diffuse emission of annihilation gamma-rays in th

74 results in efficient energy transfer to and bright emission of hydroporphyrin in the deep-red (640-6

75 ts many favorable traits such as small size, bright emission, and exceptional stability-has become a

76 .The finding can lead to a new generation of bright emitters that can be used as ECL labels.

77 If they are representative of the bright end of the [C ii] luminosity function, then they

78 Here we describe CyOFP1, a bright, engineered, orange-red FP that is excitable by c

79 Suitable labels must be bright enough for one EV to be detected without the gene

80 ue was directly stimulated by light that was bright enough to induce an action potential in an uncoup

81 Here we report on a bright equatorial atmospheric feature imaged in 2015 tha

82 Besides the optically accessible bright excitons, these systems exhibit a variety of dark

83 ing active elongation invariably contained a bright F-actin patch at the tip, whereas actin-depleted

84 rted a sequential differentiation from NKG2C(bright)FcRgamma(+) to NKG2C(bright)FcRgamma(-) NK cells.

85 ions was lower than that of concurrent NKG2C(bright)FcRgamma(-) NK cells, further supporting that FcR

86 ation from NKG2C(bright)FcRgamma(+) to NKG2C(bright)FcRgamma(-) NK cells.

87 Thus, the spatial position of a bright feature, such as a celestial body, may be encoded

88 Bright field (BF) optical microscopy is regarded as a po

89 introduce quantitative image restoration in bright field (QRBF), a digital image processing method t

90 ble automated identification of particles by bright field imaging, followed by classification by SHG.

91 n can expand the functionality of commercial bright field microscopes, provide easy field detection o

92 Cell growth and viability were evaluated by bright field microscopy.

93 th high-angle annular dark-field and annular bright-field (HAADF and ABF) imaging and nanoscale compo

94 Bright-field and scanning electron microscopy establishe

95 We present an integrative method combining bright-field dual-colour chromogenic and silver ISH assa

96 Bright-field image retinal maps and fluorescent images w

97 Here, we report a time-lapse-based bright-field imaging analysis system that allows us to i

98 Specifically, we performed high-throughput bright-field imaging of numerous drug-treated and -untre

99 lular drug responses only by high-throughput bright-field imaging with the aid of machine learning al

100 methods to trace impregnated dendrites from bright-field microscopy images that enabled accurate 3-d

101 ective under different recording conditions (bright-field microscopy with simultaneous patch-clamp re

102 d magnetite by employing a strain-sensitive, bright-field scanning transmission electron microscopy a

103 rganization of the crystals were examined by bright-field transmission electron microscopy and electr

104 ening drug discovery platforms, for example, bright-field, phase contrast, and fluorescence microscop

105 A bright flash of illuminating light is required to acquir

106 following parameters: scotopic standard and bright-flash a-wave implicit times, photopic 30-Hz flick

107 was found to be highest in fried potato with bright-fleshed (900.81microgkg(-1)) and lowest in toaste

108 ncing as additional optical sensing owing to bright fluorescence of rhodamines if used for DNA labeli

109 together by an intercellular PPI, producing bright fluorescence or contrast for electron microscopy.

110 The bright fluorescent cytosine analogue tC(O) stands out am

111 platform for the synthesis of new moderately bright fluorescent dyes remarkable for their chemical st

112 By expressing a bright fluorescent reporter protein at the endogenous le

113 P-2 resulted in complementation of YFP and a bright fluorescent signal by confocal microcopy that loc

114 In this work, ultra-bright fluorescent silica nanoparticles (NPs) labels hav

115 a mean area of 1.04+/-0.20microm(2)), while bright fluorescent spots inside the cells were evident b

116 Bright fluorophores in the near-infrared and shortwave i

117 ht curve has at least five peaks and remains bright for more than 600 days; the absorption lines show

118 Dyes that are sufficiently bright for use at low, nonperturbing intracellular conce

119 far from the Earth are not affected by these bright foregrounds.

120 ted data processing strategies, indicating a bright future for NTS.

121 e training vision offers opportunities for a bright future for young neuroscientists as they assume t

122 aled to be a focused MTKI that should have a bright future in fighting a wide range of cancers.

123 y, sensitivity and stability, it will have a bright future in the field of medical diagnosis.

124 current challenges that need to be met for a bright future of HSA-binding.

125 s at lower cost, these efforts should have a bright future.

126 Compton back-scattering and results in ultra-bright gamma-photon emission with brightness of 10(25)

127 e we propose an all-optical scheme for ultra-bright gamma-ray emission and dense positron production

128 tatron radiation from LWFA to be extended to bright gamma-ray radiation, which is beyond the capabili

129 In this scheme, bright gamma-rays are generated by radiation-trapped ele

130 Green reporter, the consumption of high cost Bright-Glo Luciferase Assay is reduced, making this assa

131 ized by the presence of golden-colored eyes, bright green bodies and delicate wings with dense venati

132 on of CP 3 in dry 1,2-dichloroethane affords bright green diamagnetic Co(III)(TPP)(N-py-DTDA(-)), 3b,

133 m the western Atlantic, are known to exhibit bright green fluorescence.

134 labeling with multiple fluorophores creates bright imaging reagents for confocal and superresolution

135 close to their companion quasars and appear bright in the far-infrared.

136 led FRET-based structural measurements, as a bright internal label in microscopy, and for fluorescenc

137 Moxifloxacin has bright intrinsic multiphoton fluorescence, good tissue p

138 on and describe the physical properties of a bright kilonova associated with the gravitational-wave s

139 Although ARID3a/Bright knockout mice died in utero, they exhibited decre

140 Our findings establish a new class of bright laboratory sources of electromagnetic radiation.

141 etic regeneration-associated WNT10B in AC133(bright) leukaemia cells, although the existence of a spe

142 ighting condition was compared with constant bright light and a control condition in dim light.

143 ensitivity: rods for dim light and cones for bright light and colour detection.

144 (SS-OCT) (Casia; Tomey, Nagoya, Japan) under bright light and dark room conditions.

145 g and psychometric assessments indicate that bright light can enhance mood, attention, and cognitive

146 Adaptation to bright light decreases the rod junctional conductance to

147 ilar changes in behavior could be induced by bright light in wild-type and rodless and coneless mice,

148 mRGCs, simulating the excitatory effects of bright light on this cell type in dark-housed mice.

149 Studies of early morning bright light or evening melatonin agonists have found im

150 nd improving sleep in dementia, namely timed bright light therapy and melatonin supplementation.

151 al to investigate the efficacy of adjunctive bright light therapy at midday for bipolar depression.

152 vidence that supports the efficacy of midday bright light therapy for bipolar depression.

153 erventions based on this physiology, such as bright light therapy to treat chronobiological disorders

154 Bright light treatment, both as monotherapy and in combi

155 Bright light-emitting diodes based on solution-processab

156 Highly bright light-emitting diodes based on solution-processed

157 required for cone photoreceptor function in bright light.

158 f cones and severely compromised function in bright light.

159 ommon feature is the experience of pain from bright light.

160 CE STATEMENT Dim-light achromatic vision and bright-light color vision are initiated in rod and sever

161 nd positively selected genes associated with bright-light vision and eye protection in other diurnal

162 subjected to enhanced positive selection for bright-light vision and relatively weak selection for di

163 which featured strong positive selection for bright-light vision.

164 erally composed of rod (dim-light) and cone (bright-light) photoreceptors with distinct morphologies

165 chemistry, we show in the rabbit retina that bright-light-induced activation of dopamine D1 receptors

166 g conditions, and cones and melanopsin under bright lighting conditions.

167 e most readily observed species due to their bright line emission.

168 Cracks appeared as bright lines with SS-OCT, with 3 crack patterns identifi

169 Both bright LT and dim-red LT were associated with improvemen

170 Bright LT improved several self-reported mean (SD) sleep

171 Participants were randomized 1:1 to receive bright LT or dim-red LT (controlled condition) twice dai

172 ean [SD] disease duration, 5.9 [3.6] years), bright LT resulted in significant improvements in EDS, a

173 Epworth Sleepiness Scale score comparing the bright LT with the dim-red LT.

174 7.88 [4.11] at baseline vs 6.25 [4.27] after bright LT, and 8.87 [2.83] at baseline vs 7.33 [3.52] af

175 [22.49] at baseline vs 106.98 [19.37] after bright LT, and 95.11 [19.86] at baseline vs 99.28 [16.94

176 Using a new bright luciferase, we here develop a genetically encoded

177 These NCs exhibit bright luminescence throughout the exchange, allowing th

178 we report five new spectral variants of the bright luminescent protein, enhanced Nano-lantern (eNL),

179 nd dynamic imaging is limited by the lack of bright luminescent proteins with emissions across the vi

180 Concurrent sound associated with very bright meteors manifests as popping, hissing, and faint

181 With aluminum, bright mode resonances are tunable over tens or hundreds

182 The bright molecular complex allowed for the fastest video-r

183 A novel one-step method for the synthesis of bright, multicolor fluorescent sulphur doped carbon dots

184 an excite this charged state and recover the bright neutral state.

185 d reorganization, enable phosphorene to be a bright new opportunity to broaden the knowledge of the e

186 CD56(bright) NK cell death occurs via both antibody- and comp

187 nd their differential ability to affect CD56(bright) NK cell functions.

188 PD-1 is expressed by CD56(dim) but not CD56(bright) NK cells and is confined to fully mature NK cell

189 antibody is involved in the decrease of CD56(bright) NK cells and may thus contribute to the onset of

190 icle, we summarize recent studies about CD56(bright) NK cells in health and disease and briefly discu

191 finding, the percentage of circulating CD56(bright) NK cells is reduced in patients with several aut

192 Noticeably, NKG2C(bright) NK cells produced more TNF-alpha in response to

193 apacity across the blood-brain barrier, CD56(bright) NK cells represent the major intrathecal NK-cell

194 Despite the fact that FcRgamma(-) and NKG2C(bright) NK cells share some phenotypic, epigenetic, and

195 Overall, we have defined CD56(bright) NK cells to be more metabolically active than CD

196 ic antibody enhances the proficiency of CD56(bright) NK cells to degranulate and induce chemokine and

197 Proportions of PD-1(bright) NK cells were higher in the ascites of a cohort

198 00c that are distinctively expressed on CD56(bright) NK cells with varied effector functions.

199 protein CIP2A and induces the death of CD56(bright) NK cells, a natural killer cell subset whose exp

200 ma loss was often confined to expanded NKG2C(bright) NK cells, both markers appeared occasionally dis

201 the diminished IFN-gamma production by CD56(bright) NK cells, whereas M2-driven upregulation of CD85

202 induce CD300c expression exclusively on CD56(bright) NK cells.

203 lly induces the expression of CD300c on CD56(bright) NK cells.

204 lower than that of neutrophils and the CD56(bright) NK-cell compartments.

205 ll parameters, including frequencies of CD56(bright), NKG2A(+), NKG2C(+), and CD57(+) NK cell subsets

206 The future is bright, not gloomy.

207 s of both lineages preferentially respond to bright objects, DALcl1 neurons have small ipsilateral, r

208 evidence that PD-1 is highly expressed (PD-1(bright)) on an NK cell subset detectable in the peripher

209 Our findings offer a bright opportunity toward the use and scale-up of MES an

210 Conventional bright optical solitons result from the interaction of a

211 eighboring small squares presented on either bright or dark backgrounds.

212 ns of TMD monolayers can be either optically bright or dark.

213 When a single square changed from dark to bright or vice versa, we found coherent population activ

214 Such a bright pair source has many practical applications and c

215 gammadeltaT17 cells displaying a CD27(-) CD3(bright) phenotype (previously associated with the invari

216 ells manifest a proliferative, CXCR4(dim)CD5(bright) phenotype compared with those in the PB and high

217 Combined with exceptionally bright phosphorescence (varphiphos = 0.45), strong 2PA m

218 The NWs have bright photoluminescence (PL) with a photoluminescence q

219 capsulated gold nanoclusters (AuNCs@ew) with bright photoluminescence by using chicken egg white prot

220 The bright photoluminescence can be tuned over nearly the en

221 The introduced quantum defects generate bright photoluminescence that allows tracking of the rea

222 nts and facilitate experimentation with new, bright, photostable fluorescent proteins.

223 ses both in vitro and in cellulo, yielding a bright, photostable fluorophore with utility in biomolec

224 Quantum dots (QDs) are extremely bright, photostable, nanometer particles broadly used to

225 The bright pink color developed due to ICT in the moderately

226 to a non-negligible population of the second bright pipi* state, which affects the dynamics, acting m

227 rstood as the Cherenkov radiation emitted by bright polariton solitons, which is enabled by the uniqu

228 predictive of the subsets, with the ID4-EGFP(Bright) population being mostly, if not purely, SSCs, wh

229 Here, the bright potential of MOF materials as emerging multifunct

230 ed for direct methanol fuel cells, providing bright promise for such hybrid membranes in this applica

231 Inspired by the bright prospects of solid Li-metal batteries, increasing

232 be resolved with high spatial resolution at bright pulsed spallation neutron sources due to recent d

233 The bright, rapidly fading UV emission indicates a high mass

234 The bright red appearance of soluble solid separated by high

235 PJ provided the films with a bright red color, and acted as a plasticizer.

236 Here, we report a bright red fluorescent voltage indicator (fluorescent in

237 A sharp color change from light yellow to bright red is triggered when the liberated indicator 2',

238 Bright red light was observed with the addition of ODI a

239 a Na(+) selective fluoroionophore based on a bright red-emitting BODIPY chromophore.

240 tive to green FP-based voltage indicators, a bright red-shifted FP-based voltage indicator has the in

241 Bright-red colors in vertebrates are commonly involved i

242 choroidal reflectivity, with the RPE as the bright reference standard and the vitreous as the dark r

243 ntually biases the animal trajectory towards bright regions.Active locomotion requires closed-loop se

244 A bright, renal-excreted, and biocompatible near-infrared

245 al dimmings completely enclosed by irregular bright rings, which originate and expand outward from th

246 Pluto's Sputnik Planitia is a bright, roughly circular feature that resembles a polar

247 -time videos, the initial gaps appeared as a bright scattered area mainly on dentin floor and rapidly

248 exocytosis and endocytosis, constituting new bright sensors for these key steps of synaptic transmiss

249 Structural colours usually appear bright, shiny, iridescent or with a metallic look, as a

250 ced many fields by providing extraordinarily bright, short X-ray pulses.

251 hibited the same progression from an initial bright singlet state (species I) to a delocalized dark s

252 reduce the energy gap between triplets and "bright" singlets, allowing thermal population exchange b

253 components, mimicking the appearance of near-bright solitary waves over short timescales.

254 he behaviors in Kerr-comb systems, including bright-solitons, dark-solitons, and a large class of per

255 tle change in momentum, transform these to a bright source of MeV atoms.

256 of poly(lactic-co-glycolic acid) (PLGA) with bright, spectrally defined quantum dots (QDs) to enable

257 gnificantly with PCR-positive AK (P < 0.05): bright spots (round or ovoid hyperreflective objects wit

258 Thus, bright spots resulting from the conjugates at the bottom

259 crobead column revealed captured bacteria as bright spots that were easily counted manually or using

260 ry-scale wave pairs and by a small number of bright spots.

261 figure was 98.2% for clusters and 48.2% for bright spots.

262 Here we report observations of the bright star HD 195689 (also known as KELT-9), which reve

263 fs blue shift and decay of the Franck-Condon bright state arising from relaxation along the reactive

264 The ultrafast Franck-Condon bright state relaxes to a dark excited state, which FSRS

265 ved into the peripheral blood (CXCR4(dim)CD5(bright) subpopulation) have higher cell surface levels o

266 loss was mostly accumulated within the NKG2C(bright) subset in NKG2C(+/+) subjects, whereas NKG2C(-)F

267 ly impaired IFN-gamma production by the CD56(bright) subset of cells.

268 ing conditions of ambient illumination, from bright sunlight to single-photon counting under dim star

269 of light intensities, from dim starlight to bright sunshine.

270 e reliable data retrievals over California's bright surface areas than previous data sets.

271 (bright), CD11b(bright), CD66b(bright), CD63(bright) surface phenotype, proinflammatory cytokine secr

272 Further, higher frequency of CD4(dim)CD8(bright) T cells (R = -0.62; p </= 0.001), but not CD8 si

273 Thus, CD4(dim)CD8(bright) T cells are capable of HIV control in the CNS an

274 secreted from astrocytes induced CD4(dim)CD8(bright) T cells by 2-fold in vitro.

275 Brain CD4(dim)CD8(bright) T cells from HIV-infected mice exhibited anti-HI

276 g HIV infection can give rise to CD4(dim)CD8(bright) T cells, likely through a Wnt signaling-dependen

277 This population is known as CD4(dim)CD8(bright) T cells.

278 population, the minority populations of CD8(bright)T cells are significantly more effective in inhib

279 e tool for labeling proteins with a minimal, bright tag in quantitative high-resolution imaging.

280 rising and decay times were obtained for the bright to dark than the dark to bright changes.

281 that adam13 interacts with the arid3a/dril1/Bright transcription factor.

282 LC at the vicinity and resulted in a dark-to-bright transition of optical image of LCs.

283 These bright ultrathin NWs may be used as a model system to st

284 f porcine liver esterase (PLE) to reveal the bright unmodified VoltageFluor.

285 tage sensing to achieve fast, sensitive, and bright voltage sensing using two-photon (2P) illuminatio

286 olaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of ge

287 sitive, CD8 single positive, and CD4(dim)CD8(bright)) were found in NSG-huPBMC mouse brain within 2 w

288 Bright white dual emission containing blue fluorescence

289 placebo light group, the group treated with bright white light experienced a significantly higher re

290 assigned to treatment with either 7,000-lux bright white light or 50-lux dim red placebo light (N=23

291 -induced choroidal neovascularization (CNV), bright white-light exposure, and Fam161a-associated inhe

292 of CLL cells that migrate are CXCR4(dim)CD5(bright) with higher CD49d, CD80, CD86, and HLA-DR compar

293 sars and occasionally produces exceptionally bright X-ray flares.

294 Using tobacco (Nicotiana tabacum) 'Bright Yellow 2' cell suspension and leaves, evidence is

295 y images were analyzed for LRP, defined as a bright yellow block on the near-infrared spectroscopy bl

296 acid and contributed to a more saturated and bright yellow color, a better taste balance, and a more

297 an white bat Ectophylla alba colors its skin bright yellow with the deposition of the xanthophyll lut

298 vidence for cAMP function in plants, tobacco Bright Yellow-2 (BY-2) cells were transformed with the c

299 alized to the cytosol and nucleus of tobacco bright yellow-2 cells, but colocalized with mitochondria

300 te expansion in tobacco (Nicotiana tabacum) 'Bright Yellow-2' cells: massive delivery of preexisting