ライフサイエンスコーパス: bristle

1 the caterpillar, namely the tegument and the bristle.

2 lusters of cells at the sites of each future bristle.

3 ses N phenotypes in the adult mechanosensory bristle.

4 ptors in hair cells as well as in Drosophila bristles.

5 veins, increased bristle density, and tufted bristles.

6 of achaete allows formation of the remaining bristles.

7 described; it causes a loss of some sensory bristles.

8 te expression that results in the additional bristles.

9 variation in the number of ventral abdominal bristles.

10 ocation of the longitudinal actin bundles in bristles.

11 filaments are prominent features of growing bristles.

12 ty to induce the formation of mechanosensory bristles.

13 gth of the scutum, through secondary loss of bristles.

14 of the rows of acrostichal and dorsocentral bristles.

15 rotation is blocked by a neighboring row of bristles.

16 ouching ground with all or nearly all of the bristles.

17 gans such as the macrochaetae, large sensory bristles.

18 t, fat, and occasionally malformed hairs and bristles.

19 tial for Dyl plasma membrane localization in bristles.

20 for male-specific morphogenesis of sex comb bristles.

21 for the morphogenesis of both denticles and bristles.

22 yl is also required for cuticle formation in bristles.

23 morphological structure composed of modified bristles.

24 velopment, poor fertility, and short slender bristles.

25 of a pupal-like abdomen with few or no short bristles.

26 repattern that allows precise positioning of bristles.

27 hereas its overexpression results in loss of bristles.

28 also rescuing dPsn-induced malformations in bristles.

29 ized cuticular structures, such as hairs and bristles.

30 For the apical bristle, a precursor is singled out and undergoes a firs

31 Our experiments suggest that recurved bristles allow the fly to sense the presence of objects

32 s involved in mechanotransduction by tactile bristles also eliminate or reduce the Johnston's organ r

33 Thus, bristle and hair cells use microvilli and cross-bridges

34 g adult development of Drosophila suppressed bristle and hair formation when induced early or redirec

35 markers in 20E-free cultures showed that the bristle and joint cells had not undergone any further mo

36 and prickle, function to regulate wing hair, bristle and ommatidial polarity.

37 log Rheb each resulted in duplication of the bristle and socket cells, progeny of the pIIa cell, and

38 that profilin promotes actin assembly in the bristle and that a balance between capping protein and p

39 to further define Ubx function in patterning bristle and trichome patterns in the legs.

40 mation of branched arista laterals, branched bristles and a strong multiple hair cell phenotype that

41 ignaling controls the orientation of sensory bristles and cellular hairs (trichomes) along the antero

42 cause the classic Minute phenotypes of small bristles and delayed development.

43 to be the main contributor while both nylon bristles and elastomers could act as absorptive sinks fo

44 ore, that Ed is required to suppress sensory bristles and for proper wing vein specification during a

45 croscopy shows that escapers have defects in bristles and hairs, indicating that this motor protein p

46 present around the periphery of other insect bristles and hairs, longitudinal ridges in lepidopteran

47 The pattern of bristles and intervening epithelial cells (ECs) becomes

48 ve opposite effects on the number of sensory bristles and on wing venation phenotypes induced by modi

49 and nonvolatile pheromones through gustatory bristles and pegs distributed on multiple body parts inc

50 esults in an increased production of sensory bristles and sensory organ precursor (SOP) cells on the

51 entation and the number of ventral abdominal bristles and sex comb teeth) in a natural population of

52 oduce epidermal hairs, the shafts of sensory bristles and the lateral extensions of the arista are at

53 for TAF250 during ovary, eye, ocelli, wing, bristle, and terminalia development as well as overall g

54 terminate in either a spikelet or a sterile bristle, and these structures appear to be paired.

55 Joints, bristles, and claws were dependent on 20E for differenti

56 tion of chitin, a major cuticle component in bristles, and disrupting Rab11 function leads to phenoty

57 s governing the parallel alignment of hairs, bristles, and ommatidia in Drosophila have all served as

58 r than 400 ng 20 E/ml) than pretarsal claws, bristles, and other joints (greater than 40 ng 20E/ml).

59 uction of mechanoreceptor currents by insect bristles, and seems likely to represent a new kind of me

60 ncluding dark deposits on the eye, truncated bristles, and semilethality.

61 er adult leg, the six distalmost joints, the bristles, and the pretarsal claws, were examined to inve

62 nchung-expressing neuron under each recurved bristle are essential for its mechanosensitivity and the

63 Insect bristles are model mechanosensory organs.

64 arized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites.

65 Macrochaetes, large sensory bristles arranged into species-specific stereotypical pa

66 Su(Raf) Hsp83 mutants can extend to thoracic bristles as well as previously reported effects on viabi

67 us and ectopic Ubx expression are limited to bristles at specific locations.

68 However, the mechanosensory bristles at the Drosophila wing margin have been reporte

69 curvature is planar and far greater near the bristle base.

70 rneal epithelium was removed with a rotating bristle brush and stromal thickness monitored for 1 hour

71 ved in lateral inhibition of interommatidial bristles but is not required for induction of the cone c

72 mir-9a induces a subtle increase in sensory bristles, but a substantial loss of wing tissue.

73 Large bristles called macrochaetes are arranged into species-s

74 The nanotube bristles can also be chemically functionalized for selec

75 In contrast, the long bristle cell extension is supported by equally long (up

76 thway inhibitor, and H heterozygotes exhibit bristle cell fate phenotypes reflecting gain-of-Notch si

77 effector for mediating the attachment of the bristle cell membrane to chitin to establish a stable cu

78 the reader, into applying your skills to the bristle cell.

79 Drosophila bristle cells are shaped during growth by longitudinal b

80 on, loss of lilli in adult photoreceptor and bristle cells results in a significant decrease in cell

81 In other species, bristle cells that make up the sex combs arise in their

82 the actin filaments that support elongating bristle cells.

83 oneural activity that can rescue the loss of bristles characteristic of wg mutants.

84 unction leads to phenotypes that result from bristle collapse rather than a failure to elongate.

85 ayer that encloses the pupa) leading to less bristle curvature along the shaft.

86 Thus, the pattern of bristle curvature is a product of both extrinsic factors

87 We have identified an essential role for the bristle cuticle in the maintenance of bristle structure

88 in addition to senseless, contributes to the bristle defects of the mir-9a mutant.

89 that give rise to Drosophila mechanosensory bristles, Delta (Dl) ligand in the sensory organ precurs

90 wing margin, thickened wing veins, increased bristle density, and tufted bristles.

91 tly evolved, male-specific array of modified bristles derived from transverse bristle rows found on t

92 The effects of Ubx on bristle development are highly dependent on the context

93 bchs function restores viability and normal bristle development in animals with reduced rab11 functi

94 lates the assembly of actin filaments during bristle development in Drosophila and filopodia formatio

95 ases Ubx function is required shortly before bristle development is blocked.

96 Drosophila melanogaster bristle development is dependent on actin assembly, and

97 QTL mapped to the same location as candidate bristle development loci, several QTL regions did not en

98 Suppression of bristle development or changes in bristle morphology in

99 sophila melanogaster wing vein and scutellar bristle development to screen Rab proteins predicted to

100 ntennal growth, joint formation, and sensory bristle development).

101 s in metamorphosis including leg elongation, bristle development, and pigmentation.

102 Here, we describe a new gene involved in bristle development, identified through the use of natur

103 During Drosophila sensory bristle development, precursor cells segregate Numb asym

104 x act antagonistically to one another during bristle development.

105 ristle structure and shape at late stages of bristle development.

106 For the posterior sternopleural bristle, development on T3 ceases after proneural cluste

107 Drosophila bristles display a precise orientation and curvature.

108 ty and patterning defects in eye and sensory bristles due to cis-regulatory lesions in the cell cycle

109 wings with ectopic sensilla and chemosensory bristle duplications.

110 d and collectively bear some 60,000 adhesive bristles, each with two terminal pads.

111 The actin bundles essential for Drosophila bristle elongation are hundreds of microns long and comp

112 ng bristle rudiment to provide direction for bristle elongation, a process thought to be orchestrated

113 actin bundle structure and found that during bristle elongation, snarls of uncross-linked actin filam

114 e plasma membrane is also limited throughout bristle elongation.

115 en its function is reduced in the Drosophila bristle, F-actin levels increase and the actin cytoskele

116 e genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ

117 Surface appendages such as bristles, feathers and hairs exhibit both long- and shor

118 s the ability of ectopic wingless to inhibit bristle formation and furrow progression.

119 al gene expression (and thus interommatidial bristle formation) and positions the morphogenetic furro

120 ughterless to promote furrow progression and bristle formation, respectively, can block ectopic wingl

121 compartment boundaries - in consequence, the bristles from each segment send their nerves to the CNS

122 nal, conductive brushes with carbon nanotube bristles grafted on fibre handles, and demonstrate their

123 caused by loss of Jagunal affects oocyte and bristle growth.

124 rding to the head size (normal or short) and bristle hardness (medium or soft) of the TB used.

125 The performance of these bristles has been limited by the oxidation and degradati

126 ting-rotating powered toothbrush with a soft-bristle head resulted in higher GM stability after root

127 ormones brassinosteroids (BRs) in specifying bristle identity and maintaining spikelet meristem deter

128 -of-function bsl1 mutants fail to initiate a bristle identity program, resulting in homeotic conversi

129 unction is the appearance of ectopic sensory bristles in addition to loss of olfactory sensilla, owin

130 ss to specify the precursors of most sensory bristles in Drosophila.

131 iated with an increase of 0.35 sternopleural bristles in laboratory strains in two large samples of w

132 neurons of about 20 male-specific gustatory bristles in the forelegs.

133 e of 300+ species that share the presence of bristles in the inflorescence.

134 As is the case in bristles, in hairs dyl mutants display a dramatic phenot

135 Typical materials for constructing brush bristles include animal hairs, synthetic polymer fibres

136 ion of R8 photoreceptors and interommatidial bristles (IOBs).

137 Because the bristle is curved, the actin bundles on the superior sid

138 The morphogenesis of Drosophila sensory bristles is dependent on the function of their actin and

139 In the leg, a group of small mechanosensory bristles is organized into a series of longitudinal rows

140 e elongating cell membrane, giving the adult bristle its characteristic grooved pattern.

141 the normal morphogenesis of epidermal hairs, bristles, laterals, and dendrites.

142 rs) for the tegument library and 368 for the bristle library.

143 scription in the pIIa and pIIIb cells of the bristle lineage.

144 differentiation of post-mitotic cells in the bristle lineage.

145 In the Drosophila melanogaster sensory bristle lineages, Numb inhibits the recycling of Notch a

146 For example, taste bristles located in the male forelegs and the labial pal

147 nd ventral cibarial organs, as well as taste bristles located on the wings and tarsi.

148 (Mex67p) as the protein encoded by the small bristles locus.

149 >90% power to detect effects as low as 0.27 bristles (<1% of the total variation in bristle number)

150 length ~200 microm) are homologous to insect bristles (macrochaetes), and their colors create the pat

151 llectively formed brush-like structures with bristles made of bundles of 2-27 nups, however, the bund

152 Soft-bristle manual and powered toothbrushes were given to pa

153 rican Dental Association (ADA)-accepted soft-bristle manual brush in a non-flossing gingivitis popula

154 1 ion channel has a role in both hearing and bristle mechanosensation in fruit flies and in proprioce

155 affected by two mutations that do not affect bristle mechanotransduction, beethoven (btv) and touch-i

156 primordia of a group of small mechanosensory bristles (microchaetae), which on the legs of the Drosop

157 rthermore, overexpression of profilin in the bristle mimics many features of the cpb loss-of-function

158 able data set for future studies on hair and bristle morphogenesis, cuticle synthesis, and planar pol

159 am of cut and tramtrack to implement correct bristle morphogenesis.

160 bft locus is required for (interommatidial) bristle morphogenesis.

161 ression of bristle development or changes in bristle morphology in response to endogenous and ectopic

162 xhibit three developmental defects, abnormal bristle morphology, decreased meiotic recombination, and

163 result in female sterility, aberrant sensory bristle morphology, loss or degeneration of tissues, and

164 leton becomes disorganized, causing abnormal bristle morphology.

165 Unlike other ectopic bristle mutants, Tufted is epistatic to achaete and scut

166 led make the epidermal cells inhospitable to bristle neurons; sensory axons that are too near these c

167 for high or low, sternopleural or abdominal bristle number and an isogenic wild-type chromosome.

168 visible in the adult fly: increased sensory bristle number and the formation of a rough eye produced

169 cted genotype/phenotype associations between bristle number and variants in the introns of Delta cann

170 ncing selection or assume variants affecting bristle number are neutral, than mutation-selection equi

171 icantly associated with natural variation in bristle number as assessed by a permutation test.

172 uantitative effects of P elements on sensory bristle number can identify genes affecting neural devel

173 n interval that does not include any classic bristle number candidate genes.

174 cting Drosophila abdominal and sternopleural bristle number have occurred in 11 replicate lines durin

175 variation in sternopleural and/or abdominal bristle number in Drosophila melanogaster, for both a la

176 ariation in male abdominal and sternopleural bristle number in nature.

177 ait loci (QTL) for Drosophila mechanosensory bristle number in six recombinant isogenic line (RIL) ma

178 n polymorphisms associated with variation in bristle number is more parsimoniously explained by model

179 e independently associated with variation in bristle number measured in two genetic backgrounds as as

180 ween spontaneous mutations and QTL affecting bristle number on the deficiency-bearing chromosomes, wh

181 e complex (ASC) polymorphisms and Drosophila bristle number phenotypes in several new population samp

182 We confirm previous observations of bristle number QTL distal to 4A at the tip of the chromo

183 ophila and test the influence of E(spl)-C on bristle number variation in a natural cohort.

184 ar sc alpha is associated with sternopleural bristle number variation in both sexes and a 3.4-kb inse

185 ly shown to be associated with sternopleural bristle number variation in both sexes in a set of isoge

186 ta and sc gamma is associated with abdominal bristle number variation in females.

187 r harboring alleles having subtle effects on bristle number variation.

188 QTL for bristle number were mapped separately for each chromosom

189 Five X-linked QTL influencing bristle number were resolved to intervals of approximate

190 0.27 bristles (<1% of the total variation in bristle number) we did not replicate the association in

191 detected, of which 33 affected sternopleural bristle number, 31 affected abdominal bristle number, an

192 leural bristle number, 31 affected abdominal bristle number, and 11 affected both traits.

193 as little as 2% of segregating variation for bristle number, and saturating the region with single-nu

194 hromosome genetic variation in sternopleural bristle number, and the 3.4 kb insertion accounts for 22

195 ments as a class contributes to variation in bristle number, apparently in a sex- or trait-limited fa

196 eduction in both sternopleural and abdominal bristle number, supporting deleterious mutation-selectio

197 he proneural cluster increases adult sensory bristle number, whereas its overexpression results in lo

198 s influenced the normally invariant thoracic bristle number, while none affected invariant scutellar

199 n longevity, locomotor behavior, and sensory bristle number.

200 ber, while none affected invariant scutellar bristle number.

201 dence for epistasis between loci for clasper bristle number.

202 l X chromosome variation in female abdominal bristle number.

203 body weight, and abdominal and sternopleural bristle numbers) were measured in outbred heterozygous F

204 uronal cells associated with diverse sensory bristles of both the chemo- and mechanosensory systems.

205 rmation of a majority of the interommatidial bristles of the eye and cause defects in other external

206 ng terminal organ and in adults on the taste bristles of the labelum, the legs, and the wing margins.

207 complementation groups: broad (br), reduced bristles on palpus (rbp), and 2Bc.

208 Ubx blocks the development of two particular bristles on T3 at different points in sensory organ deve

209 major gustatory organs, including the taste bristles on the anterior wing margin.

210 by a large number of ectopic mechanosensory bristles on the dorsal mesothorax.

211 d a previously unknown function for recurved bristles on the Drosophila melanogaster wing.

212 The organization of bristles on the Drosophila notum has long served as a po

213 phila the stereotyped arrangement of sensory bristles on the notum is determined by the tightly regul

214 the wing, ommatidia in the eye, and sensory bristles on the notum.

215 ra vicina displays a pattern of four rows of bristles on the scutum resembling the postulated ancestr

216 omote the development and migration of other bristles on the third femur and to repress trichomes.

217 The distribution of sensory bristles on the thorax of Diptera (true flies) provides

218 The stereotyped, two-dimensional pattern of bristles on the thorax of Drosophila has been intensivel

219 The polarity of sensory bristles on the thorax of Drosophila is linked to the or

220 xifen (a JHM) had little effect on abdominal bristle or cuticle formation, but disrupted the developm

221 The sex comb is an array of modified bristles or 'teeth' present on the male forelegs of seve

222 Bristle pattern in the first leg also differs between ma

223 The thoracic bristle pattern of Drosophila results from the spatially

224 a variety of functional elements controlling bristle patterning and on the basis of prior work is a s

225 enotype strongly resembles the wing-hair and bristle patterning defects observed in Drosophila frizzl

226 uggest that interactions between Ubx and the bristle patterning hierarchy have evolved independently

227 Here, we use bristle patterning in the fly notum as a model system to

228 t, similar to its known function in thoracic bristle patterning, Ush functions in the control of hear

229 e their fate, ensuring efficient and orderly bristle patterning.

230 To investigate evolutionary changes in bristle patterns and ac-sc regulation by pnr, we have is

231 Other species of flies have different bristle patterns and so comparisons between them provide

232 Stereotyped bristle patterns are common among species of acalyptrate

233 ply innovative analysis to an old problem of bristle patterns in Drosophila, reducing the nonlinear i

234 x) controls specific differences between the bristle patterns of the second and third thoracic segmen

235 joints connecting the legs to the thorax, in bristle patterns, and in the positioning of some sensory

236 s in Drosophila have clearly distinguishable bristle patterns.

237 role in specifying segment- and sex-specific bristle patterns.

238 era, allowing the development of stereotyped bristle patterns.

239 t artificial selection changes the number of bristles per comb without a proportional change in the s

240 chickadee mutations suppress the abnormal bristle phenotype and associated abnormalities of the ac

241 nt suppressor of the ectopic interommatidial bristle phenotype.

242 of the bft gene is the cause of the observed bristle phenotype.

243 gulatory elements, allows the development of bristles positioned at wild-type locations.

244 op through either sex-specific patterning of bristle precursor cells or male-specific morphogenesis o

245 by transcriptional activation at sites where bristle precursors develop and by repression outside of

246 an essential function for the segregation of bristle precursors.

247 and skin mechanoreceptors in vertebrates, to bristle receptors in flies and touch receptors in worms,

248 ated that the mechanosensitivity of recurved bristles requires Nanchung and Nanchung-expressing neuro

249 Poor actin cross-bridging in mutant bristles results in altered curvature.

250 pression are sufficient to repress an eighth bristle row on the posterior second and third femurs, wh

251 of modified bristles derived from transverse bristle rows found on the first thoracic legs in both se

252 combs originate as one or several transverse bristle rows that subsequently rotate 90 degrees and ali

253 defines the positions of the mechanosensory bristle rows.

254 the socket cell overlies the newly emerging bristle rudiment to provide direction for bristle elonga

255 We found that mutations in small bristles (sbr) affect several tissues during the develop

256 s phenotypically resemble mutations in small bristles (sbr), the Drosophila homolog of the human mRNA

257 By using a conditional mutation in small bristles (sbr), which encodes an mRNA nuclear export fac

258 e adult cuticular surface, the shafts of the bristle sense organs, the lateral extensions of the aris

259 f external sensory organs, which secrete the bristle shaft and socket.

260 el actin bundles in nurse cell cytoplasm and bristle shaft cells.

261 process and that Rab11 trafficking along the bristle shaft is mediated by microtubules.

262 icle deposition by highly elongated Khc null bristle shafts suggests that conventional kinesin is cri

263 Actin filaments are important for bristle shape and elongation, while microtubules are tho

264 fabricated SH surfaces had the appearance of bristled shark skin and were robust with respect to mech

265 electron microscopic analysis of individual bristles showed that curvature is planar and far greater

266 Examination of bundle disassembly in mutant bristles shows that plasma membrane association and cros

267 of Delta-Notch signaling cannot account for bristle spacing or the gradual refinement of this patter

268 system development, as well as adult sensory bristle specification and shows that Ed interacts synerg

269 nch number and density, spikelet number, and bristle (sterile branchlet) number; these differences al

270 or the bristle cuticle in the maintenance of bristle structure and shape at late stages of bristle de

271 ment also induces the splitting of hairs and bristles, suggesting that the actin cytoskeleton might b

272 of the most abundant proteins present in the bristle, tegument, hemolymph, and "cryosecretion".

273 nchung-expressing neuron under each recurved bristle that forms an array along the wing margin as bei

274 The cuticular hairs and sensory bristles that decorate the adult Drosophila epidermis an

275 phila adult abdomen bears oriented hairs and bristles that indicate the planar polarity of the epider

276 cells survive loss of borr and develop giant bristles that may reflect their high degree of ploidy.

277 t of the cuticle is decorated with hairs and bristles that point posteriorly, indicating the planar p

278 microscopy analysis of mutant and wild-type bristles that the amount of material that connects the a

279 yed during the development of all Drosophila bristles, they play fundamentally different roles in dif

280 that the inner pupal case induces elongating bristles to bend when they contact this barrier.

281 program, resulting in homeotic conversion of bristles to spikelets.

282 dures compared with the use of a manual soft-bristled toothbrush.

283 that >2% of the genome could affect just one bristle trait and that there must be extensive pleiotrop

284 ions lead to more severe effects on variable bristle trait means than do single Hsp83 mutations.

285 mplementary effects on thoracic and variable bristle trait numbers, depending on the allelic combinat

286 the phenotypic or environmental variance of bristle traits and that complementation of E(sev) and Su

287 ith diploid per-character mutation rates for bristle traits of 0.03.

288 ev) alleles consistently influenced variable bristle traits while there were fewer effects of the Su(

289 variance, or developmental stability of the bristle traits.

290 enotypic variances of invariant and variable bristle traits.

291 es demonstrate that in developing Drosophila bristles, two cross-linking proteins are required sequen

292 ication of the correct identity of external (bristle-type) sensory organs in Drosophila.

293 PD axis, such as the positioning of specific bristle types and leg joints.

294 we studied the sex comb, a group of modified bristles used in courtship that shows marked morphologic

295 involves only the modification of individual bristles, while other species have more complex "rotated

296 s adults, sbr flies have smaller and thinner bristles with a reduced diameter, suggesting a defective

297 men of adult Drosophila bears mechanosensory bristles with axons that connect directly to the CNS, ea

298 chnin A (1) is an antifungal polyketide that bristles with ethyl groups mounted onto a caged heterotr

299 es can be stabilized by culturing elongating bristles with jasplakinolide, a membrane-permeant inhibi

300 reproduce in an all-or-nothing mode, such as bristle worms: females committed to reproduction spend r