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1 'colour barrier', owing to the intrinsically broad (about 1,500 inverse centimetres) and featureless
2 ur analyses focused on BH3 mimetics that are broad acting (ABT263 and obatoclax) or selective (ABT199
3 sponse zinc finger transcription factor with broad actions, including in differentiation, mitogenesis
4 first-generation CDK inhibitors demonstrated broad activity upon several CDKs, which likely explains
7 ributions of the fluorescence fractions were broad and chromatographically unresolved, possibly repre
10 wn to be a dimeric peripheral protein with a broad and flat basic surface that can associate with ani
11 pidemiological assessment, GBD 2015 provides broad and frequently updated measures of scabies burden
12 ictive modeling technology, and (3) foster a broad and informed discussion involving all stakeholders
13 nflammatory demyelination polyneuropathy are broad and may include dysfunctions at the nodes of Ranvi
14 eata (AA) have evolved over the decades from broad and nonspecific therapies to those that are now mo
15 we discuss vaccination strategies to elicit broad and potent immune responses based on the immunomod
16 mmunization resulted in rapid elicitation of broad and potent serum antibody responses in all four co
17 ification of donors with the most potent and broad anti-HIV serum neutralizing responses were crucial
19 few somatic hypermutations are required for broad antiviral activity, and germline-approximating var
21 lights a powerful experimental strategy with broad applicability for future studies of disorders with
22 esents a promising RNA-editing platform with broad applicability for research, therapeutics, and biot
25 catalyzed carbonylation reactions have found broad application in total synthesis of natural products
26 tosensitizer, and oxygen greatly hinders the broad application of PDT as a first-line cancer treatmen
27 This methodology shows great potential for broad application to studies of protein cofactor-small m
30 nd azido-cholesterol derivatives demonstrate broad applications of this method in organic synthesis,
32 rs are extensively employed for diagnosing a broad array of diseases and disorders in clinical settin
34 h to extract discriminant information from a broad array of features (N = 432), including: genomic da
36 ut microbiome have been found to influence a broad array of pathologic conditions ranging from heart
38 lop a methodical approach that would yield a broad assessment of National Toxicology Program's (NTP's
39 to unlock the potential of these data for a broad audience of scientists with various areas of exper
40 al shape of the continuum band, an unusually broad band extending from 2,300 to well below 1,700 cm(-
43 roups of the Chinese population and warrants broad-based, global strategy, such as greater efforts in
44 ncrease all poor households' income may have broad benefits by reducing poverty, but is unlikely to b
47 ation of patients with type 2 diabetes and a broad cardiovascular risk profile, SGLT2 inhibitor use w
48 cal frameworks were identified, addressing 5 broad categories of impact: (1) 'primary research-relate
49 ity of these mutational events fall into two broad categories: inactivation of tumor suppressor genes
53 t they were often ecological in design, used broad census geographic levels, lacked individual-level
54 amples of noncovalent complexes drawn from a broad class of nucleic acids and transient protein compl
55 nt with the stationary-state statistics of a broad class of resource-limited community dynamics model
56 detecting interfacial electron transfer in a broad class of systems, including other transition metal
58 evaluates the relative contributions of two broad classes of carbonyl-containing compounds, ketones/
59 HA-4 directly activates mRNA expression of a broad cohort of epithelial genes, including junctional f
62 tiered consent and controlled data sharing; broad consent and controlled data sharing; or broad cons
64 with communities may increase acceptance of broad consent and wide data sharing in biobank research.
67 ur group to protect chimpanzees and generate broad cross-neutralizing antibodies in animals and human
69 bivorous insects, most crustaceans have very broad diets, and the increased richness of taxa that inc
71 larity, regioregular P3EHT exhibits a rather broad distribution in polymer chain conformation due to
73 these international initiatives and ensuring broad distribution of novel technologies and open access
75 Our findings implicate TOP2A cleavage as a broad DNA damage mechanism in oncogenic translocations a
77 that Seven-up triggers Chinmo/Imp to Syncrip/Broad/E93 transition by inducing expression of the Ecdys
79 le prediction of effectors possessing either broad efficacy or host specificity, a combined secretome
80 those few tropical species that occur across broad elevational gradients (elevational generalists) re
81 2SubPc-TCBD-aniline gave rise to an intense, broad emission, which red shifts upon increasing the sol
82 concentrations of hydrogen, consistent with broad expanses of water ice, confirming theoretical pred
83 to the bryostatin supply problem also opens broad, facile, and efficient access to derivatives and p
86 ith ultra-short laser pulses containing very broad frequency spectra where their amplitudes and phase
87 tral and completely atom-economical, exhibit broad functional group tolerance, and occur readily at r
88 rn fallow deer putative populations across a broad geographic range using microsatellite and mitochon
89 we show that the Xist locus is coated with a broad H3K27me3 domain that is established during oocyte
91 ecific isolate, a dicot specific isolate and broad host range isolate infecting both monocot and dico
93 anism for Ca(2+) mobilization by beta2AR has broad implications for adrenergic signaling, cross-talk
96 phenotypes without user training, which has broad implications for improved assay development in hig
97 cing cellular function and inflammation with broad implications for inflammation-associated diseases
98 rom expanded, low density protein states has broad implications for our understanding of allostery an
99 the classic GPCR ternary-complex model, with broad implications for the multiplicity inherent in sign
100 methodological and empirical insights, with broad implications for understanding the functional and
103 ilable from the Gene Expression Omnibus, the Broad Institute, The Cancer Genome Atlas (TCGA), and the
105 d hybrid material, is truly new and may have broad interest in combination of experimental and comput
106 New World bird species distributed across a broad latitudinal gradient and estimated a suite of metr
107 eptide levels, strengthen the evidence for a broad link between the kinin-kallikrein and complement s
109 The objective of this study was to use a broad method of capturing sepsis cases to estimate 2004-
110 MMP-14 by modifying the natural non-specific broad MMP inhibitor protein N-TIMP2 to interact optimall
111 esting tool to identify high-risk groups for broad monitoring of HPV-associated cancers in resource-c
113 d GWAS-reverse genetic strategy revealed the broad natural variation in low-water-potential-induced A
114 ave also been taken, which rely on screening broad, natural genetic diversity for metabolic diversity
116 tinct antibody specificities with potent and broad neutralizing activity against all seven HCV genoty
120 ggest that visual experience determines when broad orientation selectivity emerges in visual cortical
124 ecies have so far been limited to describing broad patterns based on anonymous markers of DNA methyla
127 ucts downstream analysis such as: narrow and broad peak calling, peak annotation, and motif identific
130 y, TUBB4A mutations are known to result in a broad phenotypic spectrum, ranging from primary dystonia
132 ized by several specific genomic features as broad ploidy variation, high chromosome numbers, presenc
133 This is the first serosurvey confirming broad population-level impact in males from female HPV v
135 t antibodies alone are sufficient to provide broad protection against divergent virus strains in vivo
136 gimens have been used successfully to induce broad protection against influenza viruses in humans, an
137 irable for purposes of simplicity, cost, and broad protection against multiple National Institute of
138 e of new variants, it is essential to induce broad protection and restrict pneumococcal colonization.
139 act of water moving across the ice surface a broad quantification of surface meltwater and its draina
140 of actin polymerization and inhibition of a broad range of actin-dependent functions, including phag
142 ations of this fundamental study extend to a broad range of applications, well beyond the polymeric n
144 zes heat-sensitive reagents and simplifies a broad range of assays, including isothermal nucleic acid
145 an increased antimicrobial activity toward a broad range of bacteria, relative to OV-3, with MICs as
146 successfully applied to the alkylation of a broad range of benzimidazoles incorporating a variety of
151 substantial experience in applying CBCT to a broad range of clinical scenarios that involve critical
154 to contrasting effects of sticklebacks on a broad range of ecosystem properties, including zooplankt
155 hemical, and chemical levels has unearthed a broad range of enzymes, sulfur shuttles, and chemical me
158 ce, was conducted to identify and describe a broad range of factors affecting implementation success,
160 thereby offering the potential to generate a broad range of fluorinated small-molecule targets in liv
161 ing the maximum absorptive coupling across a broad range of frequencies in terahertz (THz) band.
164 Neighborhood conditions may influence a broad range of health indicators, including obesity, inj
167 ing antibody (bnAb) that is active against a broad range of HIV-1 primary isolates in vitro and prote
169 n any mouse model opens the possibility of a broad range of investigations of mural cells in vascular
170 l brain training programs claim to improve a broad range of mental processes; however, evidence for t
172 troduces a potentially new application for a broad range of micro- and nanoparticles to maximize rece
173 ydrocarbon (HC) surfactants, which display a broad range of mutual miscibilities in mixed micelles.
174 ative version of DA1 enhances leaf size in a broad range of natural accessions of this species, indic
176 Under the optimized reaction conditions, a broad range of nitrogen nucleophiles and carbon electrop
178 agnetic resonance (primary techniques) and a broad range of other experimental approaches (secondary
179 a more deliberative process through which a broad range of outcomes is scrutinized and the balance o
180 is a controversial one, as evident from the broad range of partly incompatible comments it has elici
182 d with higher hospitalization costs across a broad range of patient and hospital characteristics.
183 anomalous dispersion can be scaled within a broad range of peak powers against the principle of cons
184 ramatic degradation of beam quality within a broad range of peak powers, varying from just a few to h
185 st Africa that is home to individuals with a broad range of phenotypic values for eye and skin color
186 junction with MS and is expected to enable a broad range of previously challenging or intractable sep
188 ich supports generating models stable over a broad range of reconstructed and synthetic morphologies.
189 ition and demonstrate that BoNT/DC can use a broad range of sialic acid-containing moieties as co-rec
190 he review methodology enabled inclusion of a broad range of studies and permitted common features of
191 onase capable of promiscuously hydrolyzing a broad range of substrates, including organophosphates, e
192 to a theoretical framework for describing a broad range of such kinetic processes without detailed k
193 Here, we used mass cytometry including a broad range of surface markers and transcription factors
195 te a new high-yielding modular approach to a broad range of trimeric and hexameric S- and Se-bridged
200 e and abundant access to tCS may represent a broad-reaching and important advance for future mental h
201 f the CSN in regulating EGFR neddylation has broad-reaching implications for understanding how homeos
203 organic matter and is mainly localized on a broad region of 1000 square kilometers close to the 50
204 ng stochastic fluctuations witnessed as very broad resistance (R) histograms with widths comparable t
205 Producing compounds is often part of a more broad response of the plant to changes in the environmen
206 Since that time, it has been found to have a broad role in gene induction in diverse cellular respons
220 a class of hierarchical architectures and a broad set of biologically plausible learning rules gener
223 th of African Americans require input from a broad set of stakeholders, including clinicians and rese
225 t the absence of these features results in a broad specificity toward Ins(1,2,4,5,6)P5 These features
227 arrays, and silicon photomultipliers over a broad spectral range.The performance of silicon single-p
228 , the increasing resistance of bacteria to a broad spectrum of commonly used antibiotics has become a
229 onizing STAT3 could lead to suppression of a broad spectrum of cytokines and growth factors to allow
230 ponse (DDR) is essential for prevention of a broad spectrum of different human neurologic diseases.
234 preferentially, the HA190 mutant bound to a broad spectrum of glycans with alpha2,6/8/9-linked siali
235 for the detection and characterization of a broad spectrum of GMOs in routine analysis of food/feed
238 opt the design to diverse GPCRs that sense a broad spectrum of ligands, including synthetic compounds
242 tion protocol is safe and effective across a broad spectrum of patients, irrespective of the type of
243 These observations are consistent across a broad spectrum of patients, risk factors, and concomitan
245 hat affects various cellular events during a broad spectrum of physiological and pathological conditi
248 , but also provides a general approach for a broad spectrum of therapeutic proteins for in vivo appli
249 d by parametric down-conversion and report a broad spectrum with the angular Schmidt number 82.1.
257 ttenuated viral RNA production and displayed broad-spectrum antiviral activity against other alphavir
259 e findings identify ZMPSTE24 as an intrinsic broad-spectrum antiviral protein and provide insights in
260 e of innate effector cells in establishing a broad-spectrum antiviral state, as well as providing a b
262 ediated inhibition, the potential utility of broad-spectrum aptamers to overcome resistance, and mole
263 ves the way for the development of selective broad-spectrum bacterial collagenase inhibitors with pot
264 Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum beta-lactamase (BlaC) that mediates resis
266 e fused Bti's Cyt1Aa to Ls's BinA yielding a broad-spectrum chimeric protein highly mosquitocidal to
267 joene could be a lead structure in search of broad-spectrum compounds transcending the Gram negative-
270 (PAT) genes, which convey resistance to the broad-spectrum herbicide phosphinothricin (also known as
272 In the second case, the affinities of a broad-spectrum inhibitor for 22 bromodomains were calcul
273 Therefore, the risks and benefits of using broad-spectrum LRAs need to be carefully evaluated, part
274 failed clinical trials has demonstrated that broad-spectrum MMP inhibitors have limited clinical util
275 development of a safe, highly effective, and broad-spectrum RBD-based subunit vaccine to prevent MERS
277 tructural analyses guided the discovery of a broad, splicing-modulated interaction network between MD
284 e approximately 700-kDa superassembly with a broad surface suitable for membrane interaction, toward
289 aling, which translates into activation of a broad transcriptional program dominated by upregulation
290 thology and beta cell health, which may have broad translational implications for therapeutics aimed
291 with nanoridges (lacs2 and pec1 mutants); a broad translucent cuticle (cyp77a6 and dcr mutants); and
292 eening described by Glorius et al., builds a broad understanding of the impact of individual function
294 SLIM SUPER high resolution TWIM platform has broad utility in conjunction with MS and is expected to
296 um(II)-catalyzed oxidation reactions exhibit broad utility in organic synthesis; however, they often
297 e biophysical and evolutionary rationale for broad variation in protein family sizes, prevalence of c
298 clic ketimine products react smoothly with a broad variety of nucleophiles in one-pot processes enabl
299 opamine (DA) receptors that are present in a broad variety of organs and cells throughout the body.
300 -performance photodetectors operating over a broad wavelength range from ultraviolet, visible, to inf
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