ライフサイエンスコーパス: broad spectrum of

1 se from Staphylococcus epidermidis reduces a broad spectrum of 2-oxo acids, which are difficult subst

2 sonable cost-effectiveness in India across a broad spectrum of access and adherence levels.

3 extracts, suggesting that Fh15 could have a broad spectrum of action.

4 This broad spectrum of activities make MdP2'GT a promising bi

5 of novel anti-influenza therapeutics with a broad spectrum of activity against various subtypes is n

6 e great potential of this pathway to treat a broad spectrum of advanced human cancers is just now bec

7 espread range extension, barley adapted to a broad spectrum of agricultural environments.

8 alyst system for the rapid construction of a broad spectrum of alkylated scaffolds from alkyl zinc re

9 d to produce BrC in aqueous reactions with a broad spectrum of amino acids and amines.

10 SCL) we determined that TcAtg4.2 tolerates a broad spectrum of amino acids in the P4 and P3 positions

11 ers exceptionally high-level resistance to a broad spectrum of aminoglycoside antibiotics.

12 ithin a conformational ensemble occur over a broad spectrum of amplitude and time scales, and are oft

13 cally similar extraction efficiency toward a broad spectrum of analytes varying in polarity when comp

14 basic approach may find application across a broad spectrum of analytical challenges requiring elemen

15 to show that this mechanism is relevant to a broad spectrum of Antarctic ice shelves.

16 rologous expression is studied, indicating a broad spectrum of antibacterial activity and showing sel

17 gative pathogens, by efficiently expelling a broad spectrum of antibiotics from the organism.

18 similarity, thus conferring resistance to a broad spectrum of antibiotics.

19 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antiviral activity against several mem

20 ing structures for more than 15 years with a broad spectrum of applicability, including in the fascin

21 ssembly in the solid state is evident from a broad spectrum of applications in crystal engineering an

22 most important tools in modern optics with a broad spectrum of applications in, for example, frequenc

23 A broad spectrum of applications of our method is proposed

24 e design of MFCs that enable their use for a broad spectrum of applications ranging from scaled-up po

25 neling is a critical functional element in a broad spectrum of applications, ranging from semiconduct

26 acid esters are non-ionic surfactants with a broad spectrum of applications.

27 nated polycyclic aromatic hydrocarbons for a broad spectrum of applications.

28 wards the advancement of nano-barcodes for a broad spectrum of applications.

29 urther device performance optimization for a broad spectrum of applications.

30 dioxane over a wide concentration range in a broad spectrum of aqueous matrices was developed.

31 oimmune manifestations (CID-G/AI), produce a broad spectrum of autoantibodies.

32 ity of autoantibody responses, including the broad spectrum of autoantibody specificities and the con

33 of drugs, potentially useful for treating a broad spectrum of autoimmune conditions in a disease-spe

34 s and, together with silver ions, can kill a broad spectrum of bacteria, including Escherichia coli,

35 which displays inhibitory activity against a broad spectrum of bacteria, including other streptococci

36 ygen species, confers host defense against a broad spectrum of bacterial and fungal pathogens.

37 class of cationic lipids characterized by a broad spectrum of bactericidal activity resulting from a

38 of a mutational signature characterized by a broad spectrum of base changes.

39 Here we present an analysis of a broad spectrum of behavioral and physiological traits to

40 Plants respond to stresses by producing a broad spectrum of bioactive specialized metabolites.

41 hough Michael acceptors display a potent and broad spectrum of bioactivity, they have largely been ig

42 Overall, we identify a broad spectrum of biochemical activity for pseudogenes,

43 odiscs provide a new and powerful tool for a broad spectrum of biochemical and biophysical studies of

44 ng of the environment and, combined with its broad spectrum of biological activities, terrein provide

45 We conclude that hepatic mTORC2 exerts a broad spectrum of biological effects under physiological

46 This versatile cell type orchestrates a broad spectrum of biological functions and exerts very c

47 Tripterygium wilfordii Hook F., and it has a broad spectrum of biological functions.

48 The miR-17-92 cluster regulates a broad spectrum of biological processes of T cell immunit

49 the importance of macrophage plasticity in a broad spectrum of biological processes operative in heal

50 l signal transduction pathway that governs a broad spectrum of biological processes.

51 erimental method in structural biology for a broad spectrum of biological specimens from molecules to

52 scopy to examine the hydrodynamic radii of a broad spectrum of biologically important RNAs, ranging f

53 the use of these biocompatible 2D-GAs for a broad spectrum of biomedical applications, including the

54 at can induce the features of methuosis in a broad spectrum of cancer cells, including those that are

55 s for mutation-affected individuals across a broad spectrum of cancer predisposition genes.

56 th antimalarial drugs for the treatment of a broad spectrum of cancers, many of which will likely ben

57 Sudden cardiac death occurs in a broad spectrum of cardiac pathologies and is an importan

58 Family analysis indicated a broad spectrum of cardiomyopathies with a striking frequ

59 tems are needed for directing treatment in a broad spectrum of cardiovascular diseases and coagulopat

60 gression of heart failure in patients with a broad spectrum of cardiovascular diseases.

61 Radiology's engagement across a broad spectrum of care provides an excellent opportunity

62 Objective: To describe the broad spectrum of cases that require intraoperative vasc

63 use of its pleiotropic effects controlling a broad spectrum of cell functions.

64 opologically associating domains (TADs) in a broad spectrum of cell types has provided a new molecula

65 dditional chromatin-associated proteins in a broad spectrum of cell types.

66 play in tumorigenesis, currently there is a broad spectrum of cell-cycle inhibitors under developmen

67 s to VPA in budding yeast, and highlight the broad spectrum of cellular pathways influenced by this c

68 number of these loci, we demonstrate that a broad spectrum of cellular processes contribute to hydro

69 uroinflammation and can induce or modulate a broad spectrum of cellular responses.

70 effects of alertness were uniform across the broad spectrum of CG axonal conduction times.SIGNIFICANC

71 o various domains of gp120 and neutralized a broad spectrum of clade B and clade C HIV-1 isolates.

72 Glenohumeral instability encompasses a broad spectrum of clinical complaints and presentations.

73 nated glucocorticoid product can result in a broad spectrum of clinical disease, reflecting possible

74 is an inflammatory myeloid neoplasia with a broad spectrum of clinical manifestations and outcomes i

75 MPS IH is characterized by a broad spectrum of clinical manifestations, including sev

76 dual recombinase activity and give rise to a broad spectrum of clinical phenotypes.

77 ) is a multisystem autoimmune disease with a broad spectrum of clinical presentations involving multi

78 tivity and synchronization are inherent to a broad spectrum of cognitive processes and are disturbed

79 vascular disease, and cognitive disorders, a broad spectrum of collateral oral disease may be encount

80 , the increasing resistance of bacteria to a broad spectrum of commonly used antibiotics has become a

81 ULTs) serve detoxification by transforming a broad spectrum of compounds from pharmaceutical, nutriti

82 water, they catalyze peroxide oxidation of a broad spectrum of compounds, many of which are micropoll

83 f surgical procedures in the management of a broad spectrum of conditions.

84 ut also provides a unifying etiology for the broad spectrum of congenital malformations in diabetic p

85 relaxation of myometrium precontracted by a broad spectrum of contractile agonists, and that targeti

86 Tmem107(-/-) mice were affected by a broad spectrum of craniofacial defects, including shorte

87 Because a broad spectrum of cytokine therapies is now routinely us

88 A broad spectrum of cytokines and cell-surface costimulato

89 onizing STAT3 could lead to suppression of a broad spectrum of cytokines and growth factors to allow

90 lting picture, successfully tested against a broad spectrum of data, constitutes a neat rationale for

91 ut also for discovering the root causes of a broad spectrum of debilitating neuropsychiatric disorder

92 When activated, PLCPs induce a broad spectrum of defense responses including plant cell

93 chaperonin GroEL/GroES assists folding of a broad spectrum of denatured and misfolded proteins.

94 at changes in these parameters can lead to a broad spectrum of developmental abnormalities.

95 rowth failure, intellectual disability and a broad spectrum of developmental malformations.

96 ponse (DDR) is essential for prevention of a broad spectrum of different human neurologic diseases.

97 frared spectrometer with a photorheometer, a broad spectrum of different photopolymerizable formulati

98 n of disaster research stakeholders across a broad spectrum of disciplines.

99 ype of DKD will require a large study with a broad spectrum of disease severity.

100 rocedures worldwide is large and addresses a broad spectrum of disease states.

101 We studied 20 genotyped ARVC patients with a broad spectrum of disease using electrocardiographic ima

102 activator of transcription (STAT) 1 cause a broad spectrum of disease, ranging from severe viral and

103 We identified a broad spectrum of disease: hematologic (MDS 84%, AML 14%

104 A broad spectrum of diseases is characterized by myelin ab

105 rged as a significant role in treatment of a broad spectrum of diseases, including cancer, metabolic

106 (HIV)-associated heart disease encompasses a broad spectrum of diseases.

107 m 156 independent cases or families across a broad spectrum of disorders in whom previous screening h

108 , FIT-039, which suppressed replication of a broad spectrum of DNA viruses through inhibition of mRNA

109 hput platform for nontargeted screening of a broad spectrum of DoA and their metabolites based on mul

110 s a versatile signal pathway, can activate a broad spectrum of downstream targets, including myosin l

111 of insulin and GLP-1 analogs highlights the broad spectrum of drug delivery strategies that have bee

112 ng that cryo-EM can be used to investigate a broad spectrum of drug-target interactions and dynamic c

113 feedback loop may augment the response to a broad spectrum of drugs that target pathways of oncogene

114 Consistent with the broad spectrum of effects, BMI1 activated widespread gen

115 The broad spectrum of eIF4F-resistant translatomes is incomp

116 ify elective hospitalizations representing a broad spectrum of elective general/vascular operations i

117 Bias-induced oxygen ion dynamics underpins a broad spectrum of electroresistive and memristive phenom

118 itation at 488 nm show an enhancement of the broad spectrum of emission at the electromagnetic plasmo

119 approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dy

120 ron-inducible antiviral protein that traps a broad spectrum of enveloped viruses at infected cell sur

121 is an attractive antiviral host target for a broad spectrum of established and emerging viral infecti

122 Pf-5 also produces a broad spectrum of exoenzymes and natural products with a

123 While those previous models included a broad spectrum of experimental conditions and dealt only

124 Mitochondrial function refers to a broad spectrum of features such as resting mitochondrial

125 A broad spectrum of features were identified: various form

126 They confer resistance against a broad spectrum of field isolates of Puccinia graminis f.

127 and potential for commercialization across a broad spectrum of fields.

128 tivity of TTT-3002 is demonstrated against a broad spectrum of FLT3-activating point mutations, inclu

129 The described method can tolerate a broad spectrum of functional groups, including N-H and O

130 Mutations result in a broad spectrum of functional loss.

131 re pleiotropic cells capable of performing a broad spectrum of functions.

132 mor and germline WES revealed mutations in a broad spectrum of genes previously implicated in both ad

133 ncer (CRC) is a heterogeneous disease with a broad spectrum of genetic and epigenetic changes.

134 njoys robust prediction performance across a broad spectrum of genetic architectures.

135 ling pathways resulted in synergies across a broad spectrum of genetic backgrounds but often yielded

136 Mutations in MED12 are linked with a broad spectrum of genetic disorders with X-linked intell

137 (iv) Several mutants that robustly express a broad spectrum of germ-line genes in their somatic cells

138 or binding has changed from recognition of a broad spectrum of glycan receptors to a narrower spectru

139 preferentially, the HA190 mutant bound to a broad spectrum of glycans with alpha2,6/8/9-linked siali

140 for the detection and characterization of a broad spectrum of GMOs in routine analysis of food/feed

141 not be effective against all bacteria, but a broad spectrum of Gram-negative and -positive pathogens

142 monly used classes of antibiotics to treat a broad spectrum of Gram-positive and -negative bacterial

143 shCD6 can bind to a broad spectrum of gram-positive bacteria thanks to the r

144 ance, marine mussels are able to attach to a broad spectrum of hard surfaces under hostile conditions

145 Participants reported a broad spectrum of harms affecting organ recipients, dono

146 ectives on pulmonary hypertension across the broad spectrum of heart failure stages.

147 n combination providing protection against a broad spectrum of herbivores.

148 xhibited potent antiviral activity against a broad spectrum of HIV-1 strains, including those resista

149 a devastating agricultural insect pest with broad spectrum of host range, causing million dollars cr

150 le implications for improving treatment of a broad spectrum of human cancers characterized by p16(INK

151 ged clinical practice for the treatment of a broad spectrum of human cancers.

152 be deregulated in the initiating stages of a broad spectrum of human cancers.

153 , with aberrant BMP signaling resulting in a broad spectrum of human disease.

154 A broad spectrum of human diseases called ciliopathies is

155 re major epigenetic modulators involved in a broad spectrum of human diseases including cancers.

156 important catabolic pathway implicated in a broad spectrum of human diseases, begins by forming doub

157 an important catabolic pathway involved in a broad spectrum of human diseases, implies the formation

158 coding ARS enzymes have been implicated in a broad spectrum of human inherited diseases.

159 asive window for diagnosing and monitoring a broad spectrum of human pathologies as well as providing

160 ts in the functions of these RBPs underlie a broad spectrum of human pathologies.

161 ed the diagnostic value of IQ-CSF across the broad spectrum of human prions.

162 rial genetics explains how Shigella evades a broad spectrum of immune surveillance systems by coopera

163 Moreover, we identified a broad spectrum of in vivo functional hnRNP F/H targets i

164 Gram-positive bacteria cause a broad spectrum of infection-related diseases in both imm

165 rate new technologies for the diagnosis of a broad spectrum of infectious diseases.

166 here could potentially be utilized across a broad spectrum of influenza virus subtypes to improve th

167 d coordinate complementary activities from a broad spectrum of innovative researchers clearly benefit

168 Covering a broad spectrum of interesting optical, catalytic, electr

169 come IFN responsive, allowing induction of a broad spectrum of ISGs by IFN signaling.

170 how that the SCOE can be utilized to study a broad spectrum of issues involving the function of skin

171 ials, its geochemistry and geophysics, and a broad spectrum of its industrial chemistry.

172 Together, these data uncover a broad spectrum of kinases capable of overcoming dependen

173 for analogs that could potentially target a broad spectrum of kinases involved in cancer.

174 pendent activation of a reporter gene over a broad spectrum of lengths from 3 to 10 bp.

175 of generating protective immunity against a broad spectrum of lethal pathogen challenges, including

176 50 kb of GR-responsive genes and displayed a broad spectrum of lifetimes upon hormone withdrawal.

177 opt the design to diverse GPCRs that sense a broad spectrum of ligands, including synthetic compounds

178 hibition efficacy against Hela cells under a broad spectrum of light illuminations including the near

179 ategy may open a very promising avenue for a broad spectrum of light-energy-conversion technologies.

180 They also formed a broad spectrum of liver tumors, ranging from cholangioca

181 NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nano

182 pheres 1.5 mm and above in diameter across a broad spectrum of materials, including hydrogels, cerami

183 oach to be quite general and applicable to a broad spectrum of materials, including polymers, semicon

184 r utilization as tools in the diagnosis of a broad spectrum of medical problems.

185 Among a broad spectrum of medical treatments, protein therapeuti

186 s with temporal lobe epilepsy present with a broad spectrum of memory impairment, which can be assess

187 The ability to synthesize a broad spectrum of metal clusters (MCs) with their size c

188 rapid, sensitive and specific detection of a broad spectrum of microbes, which has been optimized ove

189 ed strong antimicrobial properties against a broad spectrum of microorganisms and also had the highes

190 e considered to enhance the elimination of a broad spectrum of micropollutants.

191 lated to the initiation and progression of a broad spectrum of molecular events.

192 hotspots were novel and appeared to affect a broad spectrum of molecular function, including hotspots

193 Our study characterized for the first time a broad spectrum of molecular signatures in AIM and CAEBV.

194 st lethal bloodstream infections caused by a broad spectrum of MRSA isolates.

195 nd good soft-tissue visibility suitable to a broad spectrum of musculoskeletal indications.

196 ng of cancer genetic variants, including the broad spectrum of mutation classes and the wide range of

197 ptogenetic mutagenesis by His-mSOG induces a broad spectrum of mutations including single-nucleotide

198 active synthetic approach grants access to a broad spectrum of N-benzoylguanidines under mild conditi

199 -34a, a pathogenic microRNA upregulated in a broad spectrum of NAFLD.

200 m exposure can cause anomalous behavior in a broad spectrum of nanostructured materials, and simultan

201 influence of codon translation rates on the broad spectrum of nascent protein behaviors including co

202 tic testing can be performed by users with a broad spectrum of needs, resources, and levels of techni

203 this family of radioligands for imaging of a broad spectrum of NETs.

204 Preterm infants are at risk for a broad spectrum of neurobehavioral disabilities associate

205 Neuroinflammation is associated with a broad spectrum of neurodegenerative and psychiatric dise

206 Our patient cohort exhibited a broad spectrum of neurodevelopmental phenotypes, compris

207 s, whereas their disruption is involved in a broad spectrum of neurologic and psychiatric disorders s

208 eurexin 1 (NRXN1) gene are associated with a broad spectrum of neuropsychiatric and neurodevelopmenta

209 Mutations in MECP2 cause a broad spectrum of neuropsychiatric disorders of which Re

210 rt and to assess the serum XPO4 pattern in a broad spectrum of non-alcoholic fatty liver disease (NAF

211 n human keratinocytes that are involved in a broad spectrum of nonoverlapping functions.

212 earliest stages of retinal neurogenesis in a broad spectrum of Notch pathway mutants.

213 or the in situ and real-time monitoring of a broad spectrum of odorants in aqueous solutions known to

214 s/protons, whereas DP1m neurons respond to a broad spectrum of odorants.

215 d studies and clinical trials that include a broad spectrum of older patients representative of those

216 To assist biologists working across a broad spectrum of organisms, we demonstrate multiplexed

217 Progress has been made in understanding the broad spectrum of outputs from the central complex neuro

218 ustry due to their potent activity against a broad spectrum of pathogenic bacteria and negligible tox

219 and are tailored to effectively eliminate a broad spectrum of pathogenic challenges.

220 rate production, and the need of targeting a broad spectrum of pathogenic fungi.

221 restore exon 7 inclusion in SMN1 carrying a broad spectrum of pathogenic mutations at both the 3'ss

222 ideal antibiotic should be active against a broad spectrum of pathogenic organisms with a minimal ef

223 ety of dietary products that it absorbs, the broad spectrum of pathogens that it encounters, and the

224 immunity against subsequent infections by a broad-spectrum of pathogens.

225 ophy; the encoded proteins are involved in a broad spectrum of pathways.

226 ir and sofosbuvir are highly effective for a broad spectrum of patients with HCV genotype 1 infection

227 of the SAQ angina frequency domain across a broad spectrum of patients with stable angina.

228 and caused significantly less bleeding in a broad spectrum of patients with venous thromboembolism,

229 tion protocol is safe and effective across a broad spectrum of patients, irrespective of the type of

230 These observations are consistent across a broad spectrum of patients, risk factors, and concomitan

231 imaging method with a high success rate in a broad spectrum of patients.

232 games and musical instruments, can impart a broad spectrum of perceptual benefits.

233 elusive, yet is critical to understanding a broad spectrum of phenomena.

234 ain's susceptibility to autoimmunity and the broad spectrum of phenotypes associated with these condi

235 survival of KRAS-mutant cells that harbour a broad spectrum of phenotypic variation.

236 hertz: ones that prefer to emit a relatively broad spectrum of photon pairs, potentially allowing for

237 hat affects various cellular events during a broad spectrum of physiological and pathological conditi

238 Although clusterin has been implicated in a broad spectrum of physiological and pathological process

239 active components, especially because of the broad spectrum of phytochemicals with potential health b

240 Given a broad spectrum of pleiotropic effects of coxibs, our int

241 n neural networks perform very well across a broad spectrum of possible genetic relationships.

242 unctionalization of the BASHY platform for a broad spectrum of potential applications, ranging from b

243 d and combined by arborescence to generate a broad spectrum of potential designs, called vignettes, y

244 erial anti-predator defence, Stx must kill a broad spectrum of predators.

245 monstrate that cobalamin riboswitches have a broad spectrum of preference for the two biological form

246 A broad spectrum of previously undescribed clinical and an

247 ng positive evolutionary pressure across the broad spectrum of primate lentiviruses.

248 prevention of the sepsis-induced surge of a broad spectrum of pro-inflammatory cytokines, including

249 cardiac intensivist must be familiar with a broad spectrum of procedures and their specific manageme

250 nockdown resulted in impaired induction of a broad spectrum of proinflammatory cytokines, including I

251 ical composition of ABO3 perovskites and the broad spectrum of properties they cover, inspire the cre

252 Hsp70 participates in a broad spectrum of protein folding processes extending fr

253 excellent potency and selectivity against a broad spectrum of protein kinases.

254 to stressors can precipitate the onset of a broad spectrum of psychiatric disorders and addiction in

255 ifferences in performance are predicted by a broad spectrum of psychological variables, including psy

256 Next-generation sequencing revealed a broad spectrum of putative pathogenic mtDNA point mutati

257 PA1024 could reduce a broad spectrum of quinone substrates via a Ping Pong Bi

258 y offer an alternative and is relevant for a broad spectrum of readers because of its clear translati

259 able to achieve human-level performance on a broad spectrum of recognition tasks.

260 This discovery has opened up a broad spectrum of research geared toward a better unders

261 (Oryza rufipogon) that confers an extremely broad spectrum of resistance to bacterial blight caused

262 (Oryza rufipogon) that confers an extremely broad spectrum of resistance to bacterial blight caused

263 Because a broad spectrum of resource use allows species to persist

264 expression levels of Wip1 and PTEN exhibit a broad spectrum of responses to DNA damage: from a fast t

265 re we conduct an extensive study analysing a broad spectrum of RNA-seq workflows.

266 zation of biomolecular mechanisms across the broad spectrum of scales.

267 We show that CC-projecting cells encompass a broad spectrum of selectivity to stimulus orientation an

268 sruption by xenobiotics is associated with a broad spectrum of severe adverse outcomes.

269 ble to weak-binding interactions governing a broad spectrum of signaling processes.

270 ne tags as a general strategy for studying a broad spectrum of small biomolecules in live cells and a

271 Mutation analysis identified a broad spectrum of somatic mutations in key genes involve

272 tion is a result of the activation of a very broad spectrum of specific cellular genes, with each of

273 NIK is activated by a broad spectrum of stimuli.

274 Synaptic excitation mediates a broad spectrum of structural changes in neural circuits

275 Cells in tissues can organize into a broad spectrum of structures according to their function

276 rotein-modifying enzymes that usually have a broad spectrum of substrates.

277 art of population genetic studies covering a broad spectrum of taxa including humans.

278 Here, we applied a broad spectrum of technologies including RNA sequencing,

279 hy individuals have the ability to exhibit a broad spectrum of Th subsets, defined by specific patter

280 Following their synthesis, a broad spectrum of the amino nitrogen is actively loaded

281 ur increasingly greater understanding of the broad spectrum of the deleterious health effects of expo

282 iple copies of eIF(iso)4E in B. rapa and the broad spectrum of the resistance suggest it may be durab

283 , but also provides a general approach for a broad spectrum of therapeutic proteins for in vivo appli

284 Due to the broad spectrum of these extremely rare diseases, a corre

285 Virology encompasses a broad spectrum of topics touching upon many aspects of o

286 he sample comprised adults presenting with a broad spectrum of trauma-related psychopathology, rangin

287 rt and robust and offers rapid delivery of a broad spectrum of tricyclic spiranoid ethers.

288 A broad spectrum of trifluoromethylated compounds was prep

289 We elucidated a broad spectrum of tumor suppressor genes (TSGs) and onco

290 gulation of Id proteins is associated with a broad spectrum of tumors, recent studies have identified

291 Due to the broad spectrum of underlying diseases, a multidisciplina

292 Furthermore, the broad spectrum of underlying immune disorders and the ty

293 -scale features with special shapes impart a broad spectrum of unique properties to the surface of in

294 hereby allowing routine quantification for a broad spectrum of usage.

295 come an established treatment modality for a broad spectrum of ventricular tachycardias (VTs).

296 potent neutralizing antibody responses to a broad spectrum of viruses circulating worldwide.

297 iviral function by inhibiting the entry of a broad spectrum of viruses into their host cells, presuma

298 le transmembrane proteins (IFITMs) inhibit a broad spectrum of viruses, including HIV-1.

299 of agriculture in the Fertile Crescent, the broad spectrum of wild plant species exploited by hunter

300 The 10 procedures covered the broad spectrum of workload for a vascular surgical servi