ライフサイエンスコーパス: broadly

1 ole of stress in behavior and cognition more broadly.

2 h the public on GMOs and genetic engineering broadly.

3 some, a mode of PRC2 function that may apply broadly.

4 hts into ASD and psychiatric phenotypes more broadly.

5 pancy in ribosome profiling experiments more broadly.

6 l questions can be answered by thinking more broadly about monitoring data.

7 nderlying complex traits and diseases, while broadly acknowledged, remains poorly characterized.

8 ges maintaining a poised, but inactive state broadly across the distal limb mesenchyme.

9 te-sensitive prostatic acid phosphatase as a broadly acting ectonucleotidase.

10 shes that MLIs in the lateral cerebellum are broadly activated during movement with calcium activity

11 trials in humans, with the goal of eliciting broadly active neutralizing antibodies (NAbs) that are a

12 ents for aortic aneurysms over time and more broadly addresses how medicine and surgery apply the kno

13 Dysregulated metabolism can broadly affect therapy resistance by influencing compens

14 It broadly affected the T cell compartment, inhibiting all

15 Stress broadly affects the ability to regulate emotions and may

16 moters, increased LXRE-LXRalpha binding, and broadly altered hepatic expression of LXRalpha-regulated

17 The miR-302 locus is found broadly among vertebrates, whereas the miR-290/miR-371 l

18 roles in cancer, and genome-wide assays that broadly analyze the tumor exomes or genomes.

19 reatments use topical corticosteroids, which broadly and transiently suppress inflammation and sympto

20 These characteristics make aptamers broadly applicable (e.g., as an analytical, diagnostic,

21 super-resolution imaging protocols, and are broadly applicable across biology.

22 ne or more nitrogen-containing moieties, and broadly applicable and efficient catalytic transformatio

23 particular imaging targets, the approach is broadly applicable and is expected to improve resolution

24 tic objectives are defined, based on which a broadly applicable combination therapy is proposed to co

25 The development of a broadly applicable dispersion quantification method will

26 This approach may be broadly applicable for designing effective and enduring

27 n contact for free-ranging hosts, and may be broadly applicable for investigations in wildlife diseas

28 nds were tested in vitro, making this method broadly applicable for tool compound development.

29 This framework is broadly applicable for understanding the mechanisms of s

30 enhanced ascorbate peroxidase 2 (APEX2) as a broadly applicable genetic tag that generates EM contras

31 for such materials and paving the way for a broadly applicable high-throughput-discovery and materia

32 In conclusion, this versatile method is broadly applicable in screening and characterisation of

33 h ratios (UVVR) suggesting these metrics are broadly applicable indicators of microtidal marsh vulner

34 in looping is key to gene regulation, yet no broadly applicable methods to selectively modify chromat

35 ene capping is introduced as a practical and broadly applicable strategy that can expand the scope of

36 Here we describe a broadly applicable technique called 'Ligation in situ Hy

37 tes that IDLV-mediated HDR is a powerful and broadly applicable technology to carry out site-specific

38 of BK virus (BKV) DNA precludes establishing broadly applicable thresholds for the management of BKV

39 ods validated here are general and should be broadly applicable to allow the direct and rapid detecti

40 This report describes chemistry that is broadly applicable to cysteine-rich peptides and the inf

41 The method should be broadly applicable to many bosonic and fermionic species

42 This new insight is broadly applicable to many types of molecular threading

43 ticles or semiconductors, are believed to be broadly applicable to other heterostructures with novel

44 icacious and safe CRISPR/Cas9 antimicrobial, broadly applicable to Staphylococcus aureus.

45 This analytical method is broadly applicable to study membrane protein interaction

46 ate parameters using FRAP recovery data is a broadly applicable tool for systems where intracellular

47 Broadly applicable tools for the efficient delivery of m

48 al autonomy of coordinated neural systems is broadly applicable, and our findings provide evidence of

49 A broadly applicable, practical, scalable, efficient and h

50 onate-containing N-heterocyclic carbene, are broadly applicable.

51 h enhanced mechanical properties that can be broadly applied as a thin film over large areas.

52 This platform can be broadly applied to biological research, across the spect

53 tected unbound in flow, the technique can be broadly applied to direct detection of any fluorescent t

54 lating ribosome affinity purification can be broadly applied to identify molecularly defined neurons

55 ontext of air pollution epidemiology, can be broadly applied to other fields of epidemiology.

56 -glycosylation, the roles of which have been broadly attributed to protection from proteolysis, as th

57 As the method is broadly available and applicable to available clinical s

58 itation shortfalls, underscoring the role of broadly based economic development in promoting child nu

59 Broadly, because health arises within complex, dynamic,

60 n, force precision, and force stability will broadly benefit biological applications of AFM.

61 nd genetic inheritance of metabolites varied broadly, both within and between different genetic group

62 of LA-MRSA isolated in the East of England (broadly Cambridge and the surrounding area).

63 These examples can be broadly categorized as studies of single metabolism gene

64 They further broadly caution the analyses of weak protein-protein int

65 FXS is broadly characterized by sensory hypersensitivity and se

66 lonal proliferations of lymphocytes that are broadly classified based upon their maturity (peripheral

67 s, we find that our quantitative results are broadly compatible with both microevolutionary models an

68 rapeutic resistance, but a limited number of broadly comprehensive investigations of miRNAs involved

69 ify major determinants of human flourishing, broadly conceived.

70 Nus factors are broadly conserved across bacterial species, and are ofte

71 set required for the claustrum appears to be broadly conserved across species, despite various differ

72 esidues 45-74 of the alpha1 domain, which is broadly conserved among bonobo, chimpanzee, and gorilla.

73 ',5'-adenosine monophosphate (c-di-AMP) is a broadly conserved bacterial second messenger that has be

74 the protomers and is most pronounced at the broadly conserved client-binding region.

75 l, and structural data indicate that PRC2 is broadly conserved from yeast to human in many aspects.

76 Our finding reveals a broadly conserved mechanism that regulates the phosphata

77 oRNA-99 (miR-99) family comprises a group of broadly conserved microRNAs that are highly expressed in

78 The broadly conserved Rad51/RecA family of recombinases cata

79 time is controlled in part by a set of genes broadly conserved within pooid grasses.

80 r graphical and likelihood analyses produced broadly consistent estimates of wave speed and wave widt

81 celle formulation was especially notable and broadly consistent with previous intravenous delivery of

82 d show persistent patterns of co-variability broadly consistent with the timing and phasing of the At

83 medially articulated to the thorax but also broadly contiguous with the notum anteriorly and posteri

84 nce to chemotherapeutic drugs in these lines broadly correlates with the amount of glucose uptake.

85 Here we broadly cover what is known about tricellular junctions,

86 Guinea pigs developed high titers of broadly cross-reactive antibodies; mice and ferrets exhi

87 Anti-FLE antibodies are broadly cross-reactive but poorly neutralizing, displayi

88 genotypes and found that the synbodies were broadly cross-reactive with affinities that ranged from

89 c microbiota modulate the host signaling and broadly cross-species consequences.

90 Furthermore, these peptides prove to be broadly cytotoxic, causing cell death also in normal cel

91 (OHCA) treatment have focused on identifying broadly defined location categories without considering

92 analyze the electrokinetic transport through broadly defined nanopore-type devices.

93 luence Abeta dynamics distinctively in three broadly-defined FA concentration regimes containing non-

94 Thermal buffering potential is broadly determined by: (i) the difference between the "m

95 s in allergen immunotherapy (AIT) which were broadly discussed during the first Aarhus Immunotherapy

96 eontological evidence shows that it was once broadly distributed [4, 5].

97 ore than three concussions had lower FA in a broadly distributed area of white matter compared with t

98 onally specialized ipsilateral inputs joined broadly distributed contralateral inputs.

99 insight into the structure and assembly of a broadly distributed protein secretion machine.

100 PTHR1-ligand system to explore the impact of broadly distributed replacement of alpha-amino acid resi

101 The broadly-distributed, non-topographic projections to and

102 he conclusion that urban sources of ALAN can broadly effect migratory behavior, emphasizing the need

103 and presents an appealing target for priming broadly effective antibody responses.

104 Our findings inform the development of both broadly effective immunotherapeutics and vaccines agains

105 we predict that SMELL-S and SMELL-R will be broadly effective in diagnosing smell dysfunction.

106 mited set of derivatives, and concluded that broadly effective INSTIs can be developed using this sca

107 nd computationally practical, and provides a broadly effective statistical framework for persistence

108 Consistent with this notion, broadly enhancing PFC excitability diminishes rule speci

109 ive for CXC chemokine ligand 12 (CXCL12), is broadly expressed in blood and tissue cells, and is esse

110 thelial sodium channel (DEG/ENaC) family are broadly expressed in epithelial and neuronal tissues.

111 ductance calcium-activated (BK) channels are broadly expressed in neurons and muscle where they modul

112 ng a mouse model of inducible SOX2, which is broadly expressed in oncogenic RAS-associated cancers, w

113 These results support that the broadly expressed lamin B1 regulates expression of a sub

114 ng adenocarcinoma transcript 1 (MALAT1) is a broadly expressed lncRNA involved in many aspects of cel

115 CD47 is an antiphagocytic ligand broadly expressed on normal and malignant tissues that d

116 on't-eat me' signal CD47, which is a protein broadly expressed on normal cells and often overexpresse

117 We investigated the function of two broadly expressed repressors, Runt (Run) and Suppressor

118 rns that are correlated and derived from the broadly expressed VRN2 and SWN in outgroup species.

119 However, because many proteins are broadly expressed, their acute manipulation within defin

120 expression, STAiRs 15 and 18 are spliced and broadly expressed.

121 These data broadly extend the annotated transcriptome, identify 4

122 This work provides a resource to broadly facilitate robust and long-term depletion of cel

123 th normal ontogenesis and cancer progression broadly fall into three domains: the lineage commitment

124 rent combinations of TRMs add to a core TRM, broadly found across the whole landscape of CRMs, to dis

125 ess of lignocellulose biomaterials, and more broadly fungal metabolism, has implications for diverse

126 eterodimerizers, with FZD5/FZD8-specific and broadly FZD-reactive binding domains.

127 n social anxiety, and anxiety disorders more broadly, have postulated an initial hypervigilance or fa

128 ity during collagen fibrillogenesis and more broadly highlights the utility of multimodal measurement

129 fficiencies in targeted nuclear gene editing broadly hinder Chlamydomonas research.

130 eral's Call to Action to Prevent Skin Cancer broadly identified research gaps, but specific objective

131 g the analysis of super-resolution and, more broadly, imaging data.

132 suppression in tumors, with implications to broadly improve the efficacy of cancer therapy.

133 commonly deleted in prostate cancer and lost broadly in a range of cancers but has unknown significan

134 We conclude that eIF5A functions broadly in elongation and termination, rationalizing its

135 rest specific gene 3 (gas3) and is expressed broadly in the body, it was tested whether skin cells fr

136 ning an inclusive phylogenetic analysis that broadly incorporates definitive members of the modern li

137 ituent of paraspeckles, as a p53 target gene broadly induced by mouse and human p53 in different cell

138 (DOM) in a wet weather overflow (WWF) can be broadly influenced by anthropogenic factors, such as non

139 erences between the mouse and human skin and broadly informs on the prevailing principles that govern

140 nistration of B. subtilis EPS can be used to broadly inhibit T cell activation and, thus, control T c

141 ng moth pheromone receptors, as well as more broadly into insect ecology and evolution and, consequen

142 Here, we broadly introduce the structure and organization of the

143 cting transcription elongation have not been broadly investigated.

144 epresent inter-dependent events, but MafB is broadly involved in both the processes.

145 More broadly, it shows how species differences in dispersal a

146 Two broadly known characteristics of germ cells in many orga

147 ts, suggesting avian thermal niches might be broadly limited by temperatures during nesting.

148 These signaling functions of BHB broadly link the outside environment to epigenetic gene

149 rk, we have optimized droplet digital PCR to broadly measure mutated alleles of recurrently mutated g

150 tion of Nedd4/Nedd4L expression may serve to broadly modulate the trafficking or degradation of Nedd4

151 ed more than 50%, suggesting the presence of broadly NAbs in these individuals.

152 und to the unmutated ancestor of a V2-glycan broadly neutralizing Ab, but this Ab type was not induce

153 of allowing otherwise subdominant V2-glycan broadly neutralizing Abs to develop.

154 le in conferring protection provided by both broadly neutralizing and non-neutralizing antibodies in

155 Highly potent and broadly neutralizing anti-HIV-1 antibodies (bNAbs) have

156 s encoding the light and heavy chains of the broadly neutralizing anti-HIV-1 antibody VRC01 are gener

157 e and proposes that engineered expression of broadly neutralizing antibodies (bNAbs) against HIV-1 co

158 Broadly neutralizing antibodies (bnAbs) against HIV-1 pr

159 Broadly neutralizing antibodies (bNAbs) against human im

160 In this study, a panel of broadly neutralizing antibodies (bnAbs) and nnAbs, inclu

161 sted to quantify neutralization titers by 16 broadly neutralizing antibodies (bnAbs) and sera from 30

162 Induction of broadly neutralizing antibodies (bNAbs) by HIV-1 envelop

163 Such broadly neutralizing antibodies (bnAbs) could in the fut

164 munized macaque suggests that elicitation of broadly neutralizing antibodies (bNAbs) for ebolaviruses

165 Broadly neutralizing antibodies (bNAbs) have been isolat

166 ent is to define envelope (Env) evolution of broadly neutralizing antibodies (bnAbs) in infection and

167 coprotein (Env) immunogen for elicitation of broadly neutralizing antibodies (bNAbs) is a challenging

168 Elicitation of broadly neutralizing antibodies (bnAbs) is a primary HIV

169 l agents are the mainstay for treatment, but broadly neutralizing antibodies (bNAbs) may be a viable

170 120 envelope glycoprotein of HIV-1 and three broadly neutralizing antibodies (bNAbs) of the VRC01 cla

171 of a preventative HIV vaccine able to elicit broadly neutralizing antibodies (bNAbs) remains a major

172 Majority of the broadly neutralizing antibodies (bnAbs) targeting HIV-1

173 Broadly neutralizing antibodies (bnAbs) to HIV delineate

174 Understanding how broadly neutralizing antibodies (bnAbs) to HIV envelope

175 in (Delta123) increases the ability of human broadly neutralizing antibodies (bNAbs) to inhibit E2-CD

176 erapy against HIV-1 will most likely require broadly neutralizing antibodies (bnAbs) with maximum bre

177 uccessful immunization approach for inducing broadly neutralizing antibodies (bnAbs).

178 vaccine candidates aimed at the induction of broadly neutralizing antibodies (bNAbs).

179 identification of a new generation of potent broadly neutralizing antibodies (bNAbs).

180 properties.IMPORTANCE One approach to elicit broadly neutralizing antibodies against HIV-1 is to stab

181 iruses with neutralization titers against 16 broadly neutralizing antibodies and 30 sera from chronic

182 re recognized by some of the most potent and broadly neutralizing antibodies to date.

183 dies in experimental animals have shown that broadly neutralizing antibodies to HIV-1 can prevent inf

184 on with natural immunity, we used a panel of broadly neutralizing antibodies to identify the immunoge

185 of trimer development programs is to induce broadly neutralizing antibodies with the potential to in

186 ts and macaques, but so far failed to induce broadly neutralizing antibodies.

187 al immunity, such as therapeutic vaccines or broadly neutralizing antibodies.

188 e relatively resistant to State 1-preferring broadly neutralizing antibodies.

189 e, surface-presented Env, and are targets of broadly neutralizing antibodies.

190 of a conserved epitope that is the target of broadly neutralizing antibodies.

191 ventative or therapeutic strategies based on broadly neutralizing antibodies.

192 that are recognized by trimer cross-reactive broadly neutralizing antibody (bnAb) and not by nonneutr

193 t is an ability to elicit strong and durable broadly neutralizing antibody (bNAb) responses.

194 VRC01 is an HIV-1 CD4 binding site broadly neutralizing antibody (bnAb) that is active agai

195 ted CD4 T cells by the HIV envelope-specific broadly neutralizing antibody PGT121.

196 , our method provides critical insights into broadly neutralizing antibody recognition of Env, which

197 ms by which the immune system can select for broadly neutralizing capacity.

198 n a conformation that displays predominantly broadly neutralizing epitopes and few to no nonneutraliz

199 vivo rarity of naive B cells that recognize broadly neutralizing epitopes.

200 tis C virus (HCV) pandemic, and induction of broadly neutralizing monoclonal antibodies (bNAbs) again

201 Here we selected broadly neutralizing nanobodies by phage display after i

202 DEKnull-2 elicits a stronger broadly neutralizing response and reactivity with long-t

203 ed state as this state is recognized by most broadly neutralizing, but not nonneutralizing, antibodie

204 r this purpose, we constructed LSEVh-LS-F, a broadly neutralizing, defucosylated hexavalent fusion pr

205 This was broadly observed in aortic root, arch, and total aorta o

206 oexistence of Li-rich and Li-poor phases are broadly observed on partially delithiated crystals, prov

207 that these platelet-enriched transcripts are broadly occupied by ribosomes.

208 Anterior pole progenitors were specified broadly on the dorsal-ventral (DV) axis and subsequently

209 nally, we demonstrate that the CSDns synapse broadly onto LNs and PNs throughout the AL but do not sy

210 More broadly, our findings further suggest that Hsp70 and Hsp

211 More broadly, our findings support the emerging view that cel

212 More broadly, our research demonstrates that the targeted stu

213 More broadly, our results establish the utility of the new li

214 Broadly, our results implicate aberrant PKA signaling in

215 More broadly, our work supports the idea that subtle enhancem

216 that the cell-surface protein CD276/B7-H3 is broadly overexpressed by multiple tumor types on both ca

217 Importantly, one of these sites broadly overlaps with the epitope of the well-known 4B7

218 f the pdm2009 H1 virus, to which most of the broadly prevalent, neutralizing antibodies did not bind,

219 which VEGF enhances ETS1-BRD4 interaction to broadly promote RNAPII pause release and drive angiogene

220 The MYC oncogene broadly promotes transcription mediated by all nuclear R

221 pes for use in programs intended to create a broadly protective HIV-1 vaccine.

222 hat PIV5 expressing NA may be effective as a broadly protective vaccine against seasonal influenza an

223 c antibodies and protective efficacy using a broadly protective vaccine candidate.

224 l adjuvant combination contributes to a more broadly protective vaccine while demonstrating an attrac

225 stimuli of different time domains and, more broadly, provide a compelling example of information pro

226 contribute to a cancer-prone state and more broadly provides new evidence linking hormonal imbalance

227 tients suffering from such viral infections, broadly reactive and highly sensitive influenza rapid di

228 if not hundreds, of antibodies that are both broadly reactive and potently neutralizing.

229 ertion generated, through somatic mutations, broadly reactive antibodies against RIFINs, a type of va

230 Studies have demonstrated that broadly reactive antibodies require Fc-Fc gamma receptor

231 ng influenza virus infection or immunization.Broadly reactive antibodies that recognize influenza A v

232 Conversely, if broadly reactive B cells acquire a large variety of seve

233 We suggest that broadly reactive B cells may interact with a larger frac

234 Our results suggest that broadly reactive B cells presenting a high density of pe

235 an adaptation of a previously described and broadly reactive primer set targeting the overlapping op

236 mobility patterns of modern hunter-gatherers broadly reflect local resource availability, but the pro

237 osphoproteome and strong evidence that GSK-3 broadly regulates alternative splicing.

238 In this study, we found that iNOS broadly regulates the macrophage transcriptome during M.

239 example of structure matching function for a broadly relevant computation.

240 e life sciences; however, the principles are broadly relevant to other disciplines.

241 aining periplasmic plasticity; this could be broadly relevant to other multicomponent efflux systems.

242 accounting for non-syndromic cases may prove broadly relevant to understanding other congenital disor

243 sks and computational analyses, our findings broadly replicate the pattern reported after selective l

244 al cascades that altered chromatin states to broadly reprogram responses induced by TLR4.

245 he period over which abGCs were strongly and broadly responsive to odorants.

246 Estimates were broadly robust to alternative model assumptions.

247 review of all previously published patients, broadly segregates individuals with AKT3 mutations into

248 -type tumors and specific knockdown of Mcl-1 broadly sensitizes glioblastoma cells to Bcl-xL inhibiti

249 gnalling via vocal tract resonances may be a broadly shared trait among amniotes.

250 perimental additions of inorganic N to soils broadly show a suppression of microbial activity, which

251 of transmission and their cold symptoms are broadly similar to those of the major group.

252 mena, from precisely synchronized spiking to broadly simultaneous rate increases, has been subsumed u

253 neration of correlated photon pairs that are broadly spaced in the ultraviolet (UV) and visible spect

254 The discovery of N-Cl-DCAM or, more broadly speaking, N-Cl-HAMs in chlorinated drinking wate

255 an hives into the active pocket of CYP9Q1, a broadly substrate-specific P450 with high quercetin-meta

256 e data, this synthesis of available evidence broadly supports the elevation of activation as a criter

257 ic fine structure uniformly and sufficiently broadly that it prevents valence-band-edge states from b

258 ectrometry metabolomics was used to evaluate broadly the similarities and differences in carotenoids

259 More broadly, the enhanced sampling MD simulations described

260 More broadly, the methodologies we introduce provide a genera

261 More broadly, the results offer a promising multimodal paradi

262 More broadly, the results provide a physical explanation for

263 More broadly, the results suggest that positive-feedback circ

264 Still, it is unclear how broadly these pathways apply, given that they were estab

265 Broadly, these data provide evidence for sigma1R regulat

266 More broadly, these results imply that studies of the genetic

267 More broadly, they suggest that adaptive immune responses can

268 More broadly, this study demonstrates the versatility of a hi

269 More broadly, this subtlety by which enzymes regulate functio

270 E STATEMENT Modulatory neurons often project broadly throughout the brain to alter processing based o

271 essive activation of stress response systems broadly throughout the child's body (toxic stress).

272 ample, but the mechanisms investigated apply broadly to many tissues.

273 We tested whether dopamine might act more broadly to support learning of an associative model of t

274 ral stimuli when the task required attending broadly to the peripheral locations.

275 atomy of ecological specialists extends more broadly to their developmental antennal expression profi

276 of near-IR emitting agents with multiple and broadly tunable absorption bands.

277 bGCs over weeks revealed that the robust and broadly tuned responses of most newly arrived abGCs grad

278 For example, TCs are more sensitive and broadly tuned to odors than MCs and also are much more s

279 l disparities in abortion access, which were broadly unchanged, at least as far back as 2000.

280 hat similar changes may critically, and more broadly, underlie the neural computational dysfunction p

281 engraftment of colon organoids we describe a broadly usable immunocompetent CRC model that recapitula

282 for liquid culture, there is not a standard broadly used mathematical model for bacterial population

283 Phase mapping has become a broadly used technique to identify atrial reentrant circ

284 We expect that IMAHP can be broadly used to gain insight into how changing landscape

285 anacearum Thus, the GFP strand system can be broadly used to investigate effector biology in planta.

286 ely bright, photostable, nanometer particles broadly used to investigate single molecule dynamics in

287 sy-to-use membrane DNA tension probes can be broadly used to measure intercellular tensile forces.

288 results suggest that [(18)F]FPTMP could be a broadly useful agent for the sensitive and specific imag

289 s, AAV- and CRISPR-Cas9-mediated HDR will be broadly useful for precise genome editing in basic and t

290 The approach developed here will be broadly useful for studies of function and disease-assoc

291 We expect this strategy to be broadly useful for the development of substrate probes f

292 ilability of ketones renders this reaction a broadly useful method for alkyl-(hetero)aryl coupling in

293 is biocompatible reductive chemistry will be broadly useful to practitioners working at the interface

294 es including animals and plants, making it a broadly useful tool for use in eukaryotic population-bas

295 ploited attractive interaction could be more broadly utilized as a tool not only in relation to cucur

296 More broadly, we identify neoantigen quality as a biomarker f

297 More broadly, we provide a baseline characterization of a bio

298 rthermore, some regions affect parental care broadly, whereas others affect specific behaviours, such

299 ata from cancer clinical trials to be shared broadly with researchers, we designed an open-data, crow

300 Such division of labour could function broadly within cellular signal transduction.