ライフサイエンスコーパス: broadly applicable

1 easible transition interventions that can be broadly applicable.

2 cific charged interactions and have not been broadly applicable.

3 inexpensive building blocks and is mild and broadly applicable.

4 onate-containing N-heterocyclic carbene, are broadly applicable.

5 lity, and high brightness make photoswitches broadly applicable.

6 riven biologic phenomenon that might be more broadly applicable.

7 etic manipulation we describe here should be broadly applicable.

8 ging and therapy, which may prove to be more broadly applicable.

9 Our algorithm should thus be broadly applicable.

10 techniques need to be sensitive (</=10(-4)), broadly applicable, accurate, reliable, fast, and afford

11 super-resolution imaging protocols, and are broadly applicable across biology.

12 Our workflow is broadly applicable across imaging platforms and analysis

13 , suggesting that the microcosm findings are broadly applicable across marine habitats.

14 rotein complex mapping studies and should be broadly applicable across organisms as more CF-MS datase

15 of pLGIC activation as outlined here may be broadly applicable across the eukaryotic pLGIC receptor

16 This analog-sensitive approach should be broadly applicable across the PARP family and has the po

17 rivers that emerge as the most important and broadly applicable across these key vegetation and distu

18 ng drug response between patients to develop broadly applicable adherence criteria.

19 ultiple individuals is necessary to identify broadly applicable 'allelic elements'.

20 This strategy is broadly applicable, allowing the dissection of any inter

21 thesis for chemical communication will prove broadly applicable among scent-marking mammals as others

22 Containers 1a and 1b are broadly applicable and can be used to formulate a wider

23 Our approach is broadly applicable and could reveal animal reservoirs cr

24 ne or more nitrogen-containing moieties, and broadly applicable and efficient catalytic transformatio

25 MARQUIS is a versatile method, broadly applicable and extendable to multiple mass spect

26 In this work, we present a broadly applicable and flexible tool: T-lex2.

27 This enhanced sampling is broadly applicable and has direct implications in protei

28 Here, we present a broadly applicable and inexpensive biosensing technology

29 -2 in cancer cells could potentially lead to broadly applicable and innovative therapeutic avenues.

30 on, the proteomic strategy described here is broadly applicable and is a promising route for large-sc

31 particular imaging targets, the approach is broadly applicable and is expected to improve resolution

32 r vaccination, increasing its potential as a broadly applicable and off-the-shelf therapy for cancer

33 e parent azides and alkynes makes the method broadly applicable and offers the potential to rapidly a

34 The approach is broadly applicable and provides a unifying framework to

35 We present a broadly applicable and safe method for the site-selectiv

36 We therefore devised a broadly applicable and versatile method for increasing e

37 This work describes a highly sensitive, broadly applicable, and cost-effective approach that all

38 lopment of more effective, safe, convenient, broadly applicable, and easy to manufacture vaccines for

39 ods that we demonstrate enable quantitative, broadly applicable, and inexpensive sensing with flexibi

40 The LOESS length-correction method is broadly applicable, and may be useful not only for more

41 al autonomy of coordinated neural systems is broadly applicable, and our findings provide evidence of

42 These approaches are becoming modular and broadly applicable, and show a strong potential for diss

43 Therefore, our findings provide a broadly applicable approach for classifying functionally

44 ing of patients it may prove a versatile and broadly applicable approach for localizing neurological

45 A new study in this issue describes a broadly applicable approach for this task that explicitl

46 Our results illustrate a broadly applicable approach to design physiological prot

47 rogenic nanoparticles represents a novel and broadly applicable approach to prevent the formation of

48 These results describe a potentially broadly applicable approach to understanding the interac

49 e use of cross-cutting relations and new and broadly applicable approaches in optically stimulated lu

50 These findings validate I-SELEX as a broadly applicable aptamer discovery platform that enabl

51 hermore, our experimental approach should be broadly applicable as a complement to mutagenesis for st

52 action, microRNA-based therapeutics might be broadly applicable as a therapy for this type of deafnes

53 nt sizes demonstrating their potential to be broadly applicable as a vaccination system.

54 A broadly applicable automated process could greatly incre

55 R214G IRAK2 variant as a potential novel and broadly applicable biomarker for disease or as a therape

56 This approach is powerful and broadly applicable, but has limitations when symptoms do

57 sting inhibition of autophagy as a potential broadly applicable cancer therapy.

58 A broadly applicable catalyst system consisting of water-s

59 fforts toward the creation of new useful and broadly applicable catalyst systems are ongoing.

60 Yet there are no reports of broadly applicable, catalytic methods for the synthesis

61 Discovery of this broadly applicable, chemoselective, and solvent-versatil

62 tic objectives are defined, based on which a broadly applicable combination therapy is proposed to co

63 dy SCA10 RNA toxicity and potentially define broadly applicable compounds targeting RNA AU base pairs

64 We believe that our synthesis provides a broadly applicable conceptual framework to understand an

65 l development of an extremely simple and yet broadly applicable directing group for Pd(II) , Rh(III)

66 The development of a broadly applicable dispersion quantification method will

67 These characteristics make aptamers broadly applicable (e.g., as an analytical, diagnostic,

68 This broadly applicable E2 delivery platform shows promise as

69 Broadly applicable enantioselective C-B and C-Si bond-fo

70 Utilizing a broadly applicable experimental approach to test sequenc

71 dative quenching pathway is operable in this broadly applicable fluorination protocol.

72 This synaptic silencing approach is broadly applicable for cell-type-specific and axon proje

73 ed via a unique combinatorial method that is broadly applicable for co-evaporation of other promising

74 This approach may be broadly applicable for designing effective and enduring

75 dox-labeled peptides on electrodes should be broadly applicable for detection of other proteases and

76 mental and computational approaches that are broadly applicable for efficient elucidation of disease-

77 ational removal of ssDNA exonucleases may be broadly applicable for enhancing the efficacy and ease o

78 Our methodology should be broadly applicable for epigenomic comparisons and provid

79 The Excision-seq method is broadly applicable for high precision, genome-wide mappi

80 These methods are broadly applicable for high throughput single cell chemi

81 karyotic cells, we expect this assay will be broadly applicable for investigating mechanisms of MMR i

82 n contact for free-ranging hosts, and may be broadly applicable for investigations in wildlife diseas

83 Water activity measurements were broadly applicable for measuring deliquescence points wh

84 m all three germ layers and therefore may be broadly applicable for modeling of epithelia.

85 the Cre-switchable PET reporter mice will be broadly applicable for non-invasive long-term tracking o

86 This concept might be broadly applicable for protective antibody responses to

87 This approach is broadly applicable for quantitatively mapping the molecu

88 This assay should be broadly applicable for studying the mechanisms of AAA+ p

89 This size homeostasis mechanism is broadly applicable for symmetric and asymmetric division

90 isperse polyvalent molecules may not only be broadly applicable for the inhibition of toxins and path

91 covery and validation that is accessible and broadly applicable for the progression of efforts toward

92 for a range of insects renders this strategy broadly applicable for the species-specific control of a

93 bust, and easy-to-use tool is expected to be broadly applicable for the synthesis of challenging pept

94 nds were tested in vitro, making this method broadly applicable for tool compound development.

95 This framework is broadly applicable for understanding the mechanisms of s

96 Taxon-BRI provides a broadly applicable framework for standardization and err

97 enhanced ascorbate peroxidase 2 (APEX2) as a broadly applicable genetic tag that generates EM contras

98 These methods advance our ability to develop broadly applicable genetic tools and to elucidate the un

99 atalysis method has the potential to be more broadly applicable, given the breadth of enamine catalys

100 r endothelium, the findings are likely to be broadly applicable, given the diverse cellular expressio

101 We have developed a broadly applicable high-throughput screening method that

102 for such materials and paving the way for a broadly applicable high-throughput-discovery and materia

103 These studies established a broadly applicable HIV-1 trimer production system as wel

104 that our process represents an important and broadly applicable improvement to the state of the art f

105 ly straightforward and can be expected to be broadly applicable in fragment-based drug design.

106 ination of HDX stability fingerprints may be broadly applicable in many applications for understandin

107 Such an approach may be more broadly applicable in models of outdoor, indoor, and ind

108 In conclusion, this versatile method is broadly applicable in screening and characterisation of

109 n transfer to nanocrystals is expected to be broadly applicable in solar and near-infrared light-emit

110 We expect the method to be broadly applicable in the chemical sciences, and to comp

111 e and cheap starting material should be more broadly applicable in the synthesis of additional new he

112 h ratios (UVVR) suggesting these metrics are broadly applicable indicators of microtidal marsh vulner

113 nvestigated whether these molecules are more broadly applicable inhibitors of beta2m amyloid formatio

114 A broadly applicable IR spectroscopic technique is present

115 m a transition metal using donor ligands--is broadly applicable, leading to a number of unprecedented

116 We report here a broadly applicable, longitudinal strategy for probing in

117 braries and, most notably, provides the only broadly applicable means to limit off-targeting from RNA

118 alterations in cellular metabolism may be a broadly applicable mechanism for regulating cell differe

119 s and nanostructured minerals provide a new, broadly applicable mechanism to stabilize proteins in th

120 This study demonstrates a broadly applicable mechanistic principle for how cells a

121 In this protocol, we describe a broadly applicable method based on fluorescence recovery

122 Temporal variance is a simple and broadly applicable method for analyzing bacterial swarmi

123 imP in central PK formation, and introduce a broadly applicable method for characterizing macromolecu

124 We present a broadly applicable method for the removal of unwanted va

125 -stable readily available precursors using a broadly applicable method suitable for automation.

126 ration sequencing has generated a need for a broadly applicable method to remove unwanted high-abunda

127 Here we describe a broadly applicable method using bioluminescence resonanc

128 We applied this broadly applicable methodology to 125 power plants in Te

129 Development of rapid and broadly applicable methods for complete viral genome seq

130 ng requires the development of efficient and broadly applicable methods for delivering programmable n

131 A set of broadly applicable methods for efficient catalytic addit

132 in looping is key to gene regulation, yet no broadly applicable methods to selectively modify chromat

133 The MRF-MGL represents an effective, broadly applicable model for the storage, analysis, and

134 warrants further studies that may lead to a broadly applicable molecular imaging tool to examine abn

135 an increasing part of the American diet, yet broadly applicable multiresidue pesticide methods have n

136 brain functional network strength provides a broadly applicable neuromarker of sustained attention.

137 continuous electroencephalography (EEG) as a broadly applicable, noninvasive method for neuromonitori

138 e is limited on whether these approaches are broadly applicable or affect longterm medication adheren

139 Herein, we report the rational design of a broadly applicable Pd-catalyzed method to prepare phenol

140 Thus, MuGENT is a broadly applicable platform for accelerated evolution an

141 The ternary diagrams developed here are a broadly applicable platform for rational design that off

142 these results establish the HBI design as a broadly applicable platform with therapeutic potential f

143 A broadly applicable, practical, scalable, efficient and h

144 that Dynamic BH3 Profiling can be used as a broadly applicable predictive biomarker to predict cytot

145 tion process that should serve as useful and broadly applicable principles for future design of more

146 In this article, we describe a broadly applicable process for identifying degrader hits

147 onstrates that this novel cost-effective and broadly applicable process provides new opportunities fo

148 omparisons with a potential for establishing broadly applicable quantitative BKV DNA load cutoffs for

149 The method provides a broadly applicable route for (18)F labelling of biologic

150 A broadly applicable Ru-catalyzed protocol for Z-selective

151 ns a challenge and there is a need for mild, broadly applicable, site-specific conjugation methods th

152 g in this process, our work suggests new and broadly applicable strategies for immunometabolic therap

153 Here we introduce a broadly applicable strategy for robustly controlling pro

154 Using a broadly applicable strategy for the analysis of chromati

155 Our results illustrate a broadly applicable strategy for understanding the host r

156 This broadly applicable strategy may lead to decreased pestic

157 ene capping is introduced as a practical and broadly applicable strategy that can expand the scope of

158 Amph-vaccines provide a simple, broadly applicable strategy to simultaneously increase t

159 ntity from convergence testing, we propose a broadly applicable sub-sampling protocol, whereby averag

160 surface processes, sulfidation represents a broadly applicable surface modification approach to modu

161 We have realized a reliable and broadly applicable surface modification strategy that re

162 contain a chiral amine, fueling a demand for broadly applicable synthetic methods that deliver target

163 These experiments point the way to more broadly applicable tandem catalytic transformations.

164 Here we describe a broadly applicable technique called 'Ligation in situ Hy

165 We present here a straightforward, broadly applicable technique for real-time detection and

166 Here, we describe the development of broadly applicable techniques for the mild chemical rele

167 CANE is a broadly applicable technology for dissecting causality a

168 tes that IDLV-mediated HDR is a powerful and broadly applicable technology to carry out site-specific

169 osed approach comes at a price of being less broadly applicable than MCMC.

170 atments targeting ALT may hold promise for a broadly applicable therapeutic modality specific to mese

171 suggest that nuclear reprogramming may be a broadly applicable therapeutic strategy for the treatmen

172 of BK virus (BKV) DNA precludes establishing broadly applicable thresholds for the management of BKV

173 cation-based band gap tuning we describe are broadly applicable to 3D metal halide perovskites and wi

174 s (lower capital and operating costs) and is broadly applicable to a host of electronically conductiv

175 by PIE-FI make it a powerful method that is broadly applicable to a large number of interesting biop

176 Our analysis methods are also broadly applicable to a range of cell-cell interactions

177 This method is broadly applicable to a range of RNA viruses, such as fl

178 Such autonomous schemes, which are broadly applicable to a variety of physical systems, as

179 tform for solid-state protein studies and is broadly applicable to a variety of systems and experimen

180 aining in communication skills that would be broadly applicable to a wide clinical audience.

181 The methods we described should also be broadly applicable to a wide range of biomolecular simul

182 rk flow that helps to minimize errors and is broadly applicable to agarose gel electrophoresis of RNA

183 ods validated here are general and should be broadly applicable to allow the direct and rapid detecti

184 Beyond chemokines our approach is broadly applicable to alternative systems of chemo- and

185 We expect this technique to be broadly applicable to any assembly where very short scal

186 the study of mammalian cells, but it can be broadly applicable to any cell or tissue of interest, gi

187 This exclusion list strategy should be broadly applicable to any class of RNA and improves the

188 The strategies described herein are broadly applicable to any full-length IgG or Fc-based AD

189 vide a mechanistic modeling approach and are broadly applicable to any time-to-event phenological dat

190 EM data sets from the same specimen area, is broadly applicable to biological and environmental sampl

191 The method is broadly applicable to both projection and tomography ima

192 The algorithm is fast, broadly applicable to cancer genomics data, is of immedi

193 s novel dimensionality reduction approach is broadly applicable to capture the dynamic rewiring of ge

194 Our approach is broadly applicable to cohort studies, case-control studi

195 The system may be broadly applicable to controlling invasive fishes and re

196 This method for TI into AAVS1 may be broadly applicable to correction of other monogenic dise

197 ransferable, the method should be robust and broadly applicable to counting colocalized molecules in

198 lization and communication in science and is broadly applicable to courses of any size and sub-discip

199 This report describes chemistry that is broadly applicable to cysteine-rich peptides and the inf

200 Our approach is broadly applicable to define lineage specificity in both

201 tection of protein S-acylation levels and is broadly applicable to different classes of S-palmitoylat

202 The technology is broadly applicable to discover protein interaction drug

203 The proposed mechanism may be broadly applicable to dissociative chemisorption of NH3

204 tigation of essential gene functions in vivo broadly applicable to diverse microorganisms and amenabl

205 Our approach is broadly applicable to elucidating pathogen-host interact

206 Moreover, such approaches may be broadly applicable to enhance the efficacy of radiothera

207 tic insights gleaned from our studies may be broadly applicable to fatty acid, polyketide and non-rib

208 roteins regulate NK cell function and may be broadly applicable to Fcgamma-receptor-bearing cells.

209 This approach can be broadly applicable to functional imaging of other brain

210 Our approach can be broadly applicable to functional imaging of other core b

211 he computational approaches applied here are broadly applicable to global optimization problems.

212 of omics-driven predictive modelling that is broadly applicable to guide biological discovery.

213 T cell, suggesting that this approach may be broadly applicable to heterogeneous and resistant tumor

214 D-PSR method is broadly applicable to holographic microscopy application

215 microbe-phenotype triangulation may be more broadly applicable to human microbiome studies.

216 Rapid conductance measurements will be broadly applicable to IC-based sensors that undergo anal

217 This method should be broadly applicable to identify compounds or proteins mod

218 Our method is broadly applicable to imaging the palmitoylation of cell

219 tinase inhibitors and may be a strategy more broadly applicable to inhibiting proteins that require u

220 genetic variants in native context, which is broadly applicable to investigate and improve protein fu

221 targeting was not required, the approach is broadly applicable to LABC with different phenotypes.

222 energy and microbial kinetics and should be broadly applicable to many biogeochemical systems.

223 The method should be broadly applicable to many bosonic and fermionic species

224 s suggest that this targeted approach may be broadly applicable to many diseases in which cells suffe

225 This methodology should be broadly applicable to many organisms, proteases and prot

226 Furthermore, the new approach is broadly applicable to many other phagocytes and will ena

227 tanding of tombusvirus-host interactions are broadly applicable to many other viruses, which also usu

228 This new insight is broadly applicable to many types of molecular threading

229 It is broadly applicable to mechanistic studies of chromatin i

230 mprehensive reference databases; thus, it is broadly applicable to metagenomic studies.

231 We expect that the method will be broadly applicable to modeling and predicting paired mac

232 the algorithm and metric introduced here are broadly applicable to modeling dynamics of molecular pat

233 The technique that we use is very broadly applicable to molecular electronics, nanoscale c

234 veal design principles that are likely to be broadly applicable to morphogen-patterned tissues.

235 lts suggest that the underlying chemistry is broadly applicable to nucleic acid sensing.

236 als, this mRNA delivery technology should be broadly applicable to numerous research and therapeutic

237 ing information when changing scales, and is broadly applicable to other areas.

238 This model may be broadly applicable to other bacterial and fungal organis

239 t trajectory, this approach may well be more broadly applicable to other battery chemistries.

240 This methodology can be broadly applicable to other bioconjugated systems, biose

241 te structure and catalytic activity could be broadly applicable to other CCD members and provide insi

242 macrophage phenotypes that are likely to be broadly applicable to other cell types.

243 ent loading in the Mississippi Basin and are broadly applicable to other coupled human-natural system

244 regulation of CXCR4 signaling, which may be broadly applicable to other G protein-coupled receptors.

245 ticles or semiconductors, are believed to be broadly applicable to other heterostructures with novel

246 ive therapeutic targets and may well be more broadly applicable to other immune cells.

247 Our findings are broadly applicable to other instances of signaling in ex

248 e cryptic inhibitor envelope approach may be broadly applicable to other lead optimization campaigns

249 the SSZ-13 growth mechanism may prove to be broadly applicable to other materials.

250 Temporal chromatin signatures should be broadly applicable to other models of stem cell differen

251 We expect that the methods developed are broadly applicable to other obligates, particularly to r

252 s for N- and O-glycosylation that are likely broadly applicable to other plant cell-wall-degrading en

253 is approach to chromatin profiling should be broadly applicable to other species and should shed ligh

254 Our approach is broadly applicable to other systems.

255 hibit improved voltage sensitivity should be broadly applicable to other types of PeT-based voltage-s

256 We show that the method is broadly applicable to peptide engineering, illustrated b

257 t this five-dimensional imaging method to be broadly applicable to problems in energy, materials, env

258 Our results suggest MxIF should be broadly applicable to problems in the fields of basic bi

259 This method is broadly applicable to profiling transcriptionally distin

260 This novel approach should be broadly applicable to research and clinical laboratories

261 This approach is broadly applicable to search for microbial community mem

262 pattern-matching framework we propose may be broadly applicable to spatial protein signaling througho

263 icacious and safe CRISPR/Cas9 antimicrobial, broadly applicable to Staphylococcus aureus.

264 analytical approaches demonstrated here are broadly applicable to studies of dynamic biological syst

265 opment, and show evidence that CLoNe will be broadly applicable to study clonal relationships in diff

266 Our approach is broadly applicable to study human immunity and can help

267 This analytical method is broadly applicable to study membrane protein interaction

268 The SunTag should be broadly applicable to study translational regulation in

269 dynamics and the approach presented here is broadly applicable to studying order in macromolecular s

270 -molecule fluorescence imaging and should be broadly applicable to studying protein-DNA interactions.

271 approach that we have taken in this paper is broadly applicable to the characterization of crystallin

272 UNS-guided isothermal assembly is broadly applicable to the construction and optimization

273 iple binding of the Et4N(+) guest, but it is broadly applicable to the deconvolution of other intrica

274 Finally, our qRT-PCR-based approach may be broadly applicable to the development of neutralization

275 We anticipate that FACTERA will be broadly applicable to the discovery and analysis of clin

276 The IsoTaG platform is broadly applicable to the discovery of PTM sites that ar

277 s employed in this study are likely to prove broadly applicable to the fine analysis of folding mecha

278 e provide a conceptual framework that may be broadly applicable to the functioning of other cellular

279 Our chemoproteomic platform should be broadly applicable to the investigation of other bio-ort

280 sh genotype-phenotype associations should be broadly applicable to the large list of medically and en

281 and neural control of dimorphic behavior are broadly applicable to the neural control of other behavi

282 oreover, the approach we have taken would be broadly applicable to the study of disease-prone human c

283 ChIP-nexus will be broadly applicable to the study of in vivo transcription

284 zymes through zymogen autoactivation that is broadly applicable to trypsin-like proteases of biotechn

285 iability observed within a cell type and are broadly applicable to understanding the relationship bet

286 We anticipate SHAPE-Seq v2.0 to be broadly applicable to understanding the RNA sequence-str

287 This approach should prove broadly applicable to various efforts focused on improvi

288 approach constitutes an unprecedented tool, broadly applicable to various SUMO-regulated cellular pr

289 y suggest that (89)Zr-transferrin could be a broadly applicable tool for identifying and monitoring t

290 ate parameters using FRAP recovery data is a broadly applicable tool for systems where intracellular

291 ibration constructs, provide a practical and broadly applicable toolbox for the investigation of mole

292 ed using dynamic pathway regulation, but few broadly applicable tools are available to achieve this.

293 Broadly applicable tools for the efficient delivery of m

294 mpounds are central to modern chemistry, and broadly applicable transformations that generate them ef

295 ionary origins may thus present powerful and broadly applicable treatment strategies for cancer.

296 echnology may therefore provide a practical, broadly applicable treatment that can generate anti-tumo

297 immunotherapy is a short-term available and broadly applicable treatment.

298 tro and in vivo use of IRDye 800CW CLTX as a broadly applicable tumor imaging agent.

299 thod represents the first, to our knowledge, broadly applicable use of unactivated alcohols as latent

300 ropose a chemotactic precision index that is broadly applicable, valid, and allows for a straightforw