ライフサイエンスコーパス: bromination

1 yrromethane, (ii) 1-formylation, and (iii) 9-bromination.

2 served to detect and localize the tryptophan bromination.

3 was prepared via a highly selective aromatic bromination.

4 be preferential sites for posttranslational bromination.

5 ic aromatic substitution reactions involving bromination.

6 elations increased with increasing degree of bromination.

7 further derivatized by core chlorination and bromination.

8 ydrogen bonding to catalyze their asymmetric bromination.

9 nto the biosynthetic timing of jamaicamide A bromination.

10 at relies on a new method for regioselective bromination.

11 rbonylations, methylations, silylations, and brominations.

12 Reduction (19), bromination (20), and phenylselenenylation (21), followe

13 A regioselective bromination, a biaryl coupling, and an intramolecular cy

14 enzofuran (IBF) precursor 14 in three steps (bromination, acetalization, and halogen-metal exchange/h

15 n aldehyde to a methyl enone, regioselective bromination adjacent to the carbonyl, and phenoxide disp

16 ility with one-pot bromination/arylation and bromination/alkenylation procedures to deliver meta-aryl

17 The first enzymatic asymmetric bromination and cyclization of a terpene, producing mari

18 ajority of which are produced via sequential bromination and debromination steps.

19 e (7), which also was prepared by successive bromination and dehydrobromination of the 6'-bromohomovi

20 n promoting protein oxidative damage through bromination and demonstrate that protein tyrosine residu

21 ng a double Wittig condensation, followed by bromination and di-dehydrobromination, is reported.

22 Subsequent bromination and elimination of HBr yield a polymer with

23 We herein report the palladium(II)-catalyzed bromination and iodination of a variety of alpha-hydroge

24 The Rh(III)-catalyzed selective bromination and iodination of electron-rich heterocycles

25 high-yielding, general, and practical ortho bromination and iodination reaction of different classes

26 Homodiamantane bromination and nitroxylation are accompanied by contrac

27 2-methylindole via Friedel-Crafts acylation, bromination and pivaloylation.

28 (the C-4 arene ring is readily introduced by bromination and Suzuki coupling).

29 be extended to stereospecific chlorination, bromination, and iodination reactions.

30 f the DOPC double bonds by means of specific bromination, and molecular modeling of the perturbed lip

31 corresponding 5,5'-unsubstituted bipyrrole, bromination, and Stille or Suzuki coupling.

32 We demonstrate this utility with one-pot bromination/arylation and bromination/alkenylation proce

33 guanine is the preferred purine targeted for bromination as a free nucleobase, 8-bromoadenine is the

34 ation of tyrosine occurred more readily than bromination at neutral pH, plasma levels of halides, and

35 yed a double role: (i) it allowed additional bromination at position 5 and (ii) it could afford the r

36 Zinc insertion, bromination at the 5-position, and Suzuki coupling with

37 at the 10-position undergoes regioselective bromination at the 8-position.

38 Strategic bromination at the indole C3 position greatly improved t

39 ivity; (iv) SgcC3 also efficiently catalyzes bromination but not fluorination or iodination; (v) SgcC

40 This is the first example of a regiospecific bromination by a vanadium haloperoxidase and further ext

41 avengers on yields of tyrosine nitration and bromination by EPO are examined.

42 In contrast, bromination by HOBr was independent of Br(-) and unaffec

43 ase-H2O2-Cl(-)-Br(-) system, indicating that bromination by myeloperoxidase involves the initial prod

44 experiments on the stoichiometric C(sp(2))-H bromination by Pd(OAc)2 and Br2 confirmed this predictio

45 l to install the isocyclic ring, after which bromination can be directed to the 7-position of ring B

46 ations show that Rh plays a dual role in the bromination, catalyzing the directed halogenation and pr

47 ition with an OATB, which minimizes aromatic bromination caused by excess reagent.

48 The regioselectivity of anisole bromination changed with pH, consistent with the partici

49 e formation and selective beta-halogenation (bromination, chlorination) with N-bromosuccinimide and P

50 for various organic transformations such as bromination, cohalogenation, oxidation, cyclization, rin

51 Regiospecific bromination, conversion to the substituted benzoic acid,

52 e with primary amines, followed by a one-pot bromination/cyclization process.

53 C (91.7 ng/g of total PBDD/Fs) and a higher bromination degree with increasing temperature.

54 Bromination-dehydrobromination of the 5'-bromohomovinyl

55 second double bond was best introduced by a bromination-dehydrobromination sequence, the 2-fold loss

56 the seven-membered ring by a regioselective bromination-elimination protocol, introducing a bromo su

57 ic acid-directed Pd(II)-catalyzed C(sp(3))-H bromination, enabled by quinoline ligands.

58 nistic studies also suggest that the initial bromination event is stereodetermining, and the major mo

59 introduced at the free meso-position of 7 by bromination followed by palladium-catalyzed cross-coupli

60 ted, and further combination with an in situ bromination gives access to polyfunctional pyrrole scaff

61 nslational modifications, such as tryptophan bromination, glutamic acid carboxylation, and threonine

62 ee of posttranslational processing including bromination, hydroxylation, and glycosylation define a f

63 etric increase in the level of tyrosine ring bromination (i.e., carbon-bromine bonds).

64 The final two steps involved bromination in liquid bromine and proper 2-fold dehydrob

65 The ability to suppress bromination in ring B (under acidic media) has been expl

66 tand the molecular basis for decarboxylative bromination in the biosynthesis of 1, we sequenced two P

67 The pattern of posttranslational bromination in the light sleeper peptide suggests that t

68 Results indicate that, degree and pattern of bromination, in the vicinity of the ether oxygen bridge,

69 Aryl group bromination is accomplished with such reagents as molecu

70 The capability for preferential 15-bromination is essential to install the isocyclic ring,

71 Bromination is one of the most important transformations

72 ps (Cl-DOM) are reacting with HOBr by direct bromination leading to Br-Cl-DOM and by bromine substitu

73 NBS bromination, lithium halogen exchange, and alkylation ga

74 version suggested that the initial catalytic bromination may be regioselective and stereochemistry-de

75 hemistry textbooks as electrophilic aromatic bromination, nitrosation, and nitration, respectively.

76 A in CH(2)Cl(2)), ring B is deactivated, and bromination occurs preferentially at the 15-position (87

77 Direct bromination of 1-formyldipyrromethane with 2 mol equiv o

78 ed in yields of 30 and 15%, respectively, by bromination of 2,2'-bipyrimidine, prepared from 2-chloro

79 The bromination of 2,3-diarylcyclopent-2-en-1-ones under var

80 obenzimidazole (10) was obtained by a direct bromination of 2-chlorobenzimidazole (9) with bromine-wa

81 NBS bromination of 24 followed by lactone formation gave 26

82 erivative (2e) was obtained in high yield by bromination of 2d with NBS.

83 An improved and efficient bromination of 3,5-bis(trifluoromethyl)benzene was devel

84 Regioselective bromination of 4 and 2-methoxy-9,10-dihydro-9,10-[1,2]be

85 Bromination of 4 and 6 is also reported.

86 Compound 4a was prepared via selective bromination of 6-(furan-2-yl)nicotinonitrile (2a) with N

87 The second approach entails regioselective 7-bromination of a 10,15-diarylchlorin that lacks a substi

88 Electrophilic iodination or bromination of a 5,10-diaryl-substituted chlorin proceed

89 lf) was prepared by sequential acylation and bromination of a 5-substituted dipyrromethane followed b

90 Iodination or bromination of a free base 5,10-diaryloxochlorin gave a

91 idinium salts were efficiently prepared from bromination of a series of backbone substituted N,N-bisu

92 alutamide were labeled through electrophilic bromination of a tributylstannane precursor.

93 15-, 20-, and beta-pyrrolic positions, while bromination of a zinc 5,10-diaryloxochlorin selectively

94 catalytic, asymmetric process for the alpha-bromination of acid chlorides to produce synthetically v

95 de (DMF) and tetrabromomethane (CBr4) in the bromination of alcohols.

96 Alternatively, bromination of alpha-ketoesters with CuBr2 provided 3-br

97 synthesis of a 7-aryl-imidazotriazinone via bromination of an unsubstituted imidazotriazinone follow

98 econd-order rate constant determined for net bromination of anisole by HOBr is up to 3000-times less

99 l, Br2O, and HOBr toward rates of sequential bromination of anisole was quantified.

100 Nuclear bromination of anthracene, 9-methylanthracene, and diben

101 extended to a palladium-catalyzed ortho C-H bromination of aryl-O-carbamates even at 5 mol % loading

102 The first was uncovered during the bromination of benzodiazocine 8 in dichloromethane at 0

103 A continuous-flow protocol for the bromination of benzylic compounds with N-bromosuccinimid

104 Electrophilic bromination of BN anthracene 1 with Br2, however, occurs

105 reactivity behavior and regioselectivity of bromination of BN anthracenes are consistent with the el

106 the large "dendrimer effect" observed in the bromination of cyclohexene with H(2)O(2) and NaBr cataly

107 Bromination of cytosine and formation of a piperidine-la

108 ) formation is observed, which competes with bromination of DOM (i.e., THM and HAA formation).

109 Bromination of either syn-4 or anti-4 gave anti-oriented

110 - and diastereoselective electrophilic alpha-bromination of enecarbamates to provide an atom-economic

111 ly developed method for the one-pot beta-C-H bromination of enones, which allows for rapid constructi

112 Selective bromination of gamma-methylene C(sp(3) )-H bonds of alip

113 ained with a radical-mediated regioselective bromination of indoline 12 serving as a key step.

114 We report herein the bromination of integral alkyne units in a pair of Zr(4+)

115 -) and H(2)O(2) at acidic pH results in both bromination of monochlorodimedone and modification of th

116 Bromination of nucleobases was inhibited by scavengers o

117 Bromination of oak and pine litter is limited primarily

118 ethoxysilane/tetraethoxysilane catalyzes the bromination of organic substrates (4-pentenoic acid, 3,5

119 l and soil humus, we have shown that abiotic bromination of particulate organic matter occurs in the

120 As the first evidence of abiotic bromination of particulate SOM, this study identifies a

121 n peptide that catalyzes the atroposelective bromination of pharmaceutically relevant 3-arylquinazoli

122 For the bromination of phenylacetone as a model, a productivity

123 Subsequent regioselective bromination of phthalazin-1(2H)-ones 3 with benzyltrimet

124 Bromination of ring-B and tripropyl functionalization of

125 e subject to abiotic oxidations resulting in bromination of SOM.

126 a greatly improved yield from the selective bromination of tetraphenylporphyrin (TPP) by NBS.

127 ia successive nucleophilic and electrophilic bromination of the 2-oxidocyclopentenyl cation and its r

128 hydrocupration of an alkyne, followed by the bromination of the alkenyl copper intermediate.

129 nd cleavage but rather in selective multiple bromination of the anthracenyl ligand.

130 Controlled bromination of the aromatic ring gave the monobromo oxim

131 Bromination of the methylene butyrolactone products foll

132 The NBS-mediated radical bromination of the N,N-di-tert-butoxycarbonyl protected

133 Bromination of the polycyclic oxetane 2,4-oxytwistane (r

134 urencia, Plocamium, Corallina) catalyzes the bromination of the sesquiterpene (E)-(+)-nerolidol produ

135 3), with Br(2) results in diastereoselective bromination of the stilbene units.

136 The first regioselective, mild bromination of thieno[2,3-b]pyridine is described herein

137 Bromination of trioxatricornan afforded a C(1)-symmetric

138 mediated oxidative damage of proteins (e.g., bromination of tyrosine residues) recovered in bronchoal

139 ults in oxidative damage of proteins through bromination of tyrosine residues, a heretofore unrecogni

140 oxidation and chlorination of tryptophan and bromination of tyrosine residues.

141 We report the site-selective bromination of vancomycin to produce, with substantial e

142 By the use of a high-yielding bromination of various 2,1-borazaronaphthalenes to gener

143 d in four steps starting with two successive brominations of 2-acetylfuran first with N-bromosuccinim

144 Nitration (and bromination) of the 4-methyl, 7-methyl, 7-ethyl, 3,9-dim

145 or of a duplex with no modifications such as bromination or methylation on cytosine bases.

146 d by alternating (dGdC) polymers modified by bromination or methylation, as well as for (dGdC)13 inse

147 stabilized in the Z-conformation by means of bromination or supercoiling, but not to B-DNA.

148 htly and specifically to Z-DNA stabilized by bromination or supercoiling.

149 form and dibromoacetic acid formation (i.e., bromination pathway).

150 ansition-metal-catalyzed, meta-selective C-H bromination procedure is reported.

151 A standard ortho-lithiation/bromination procedure, when applied to bromoarenes, resu

152 Fourth, subsequent bromination proceeded regioselectively at the 15-positio

153 The bromination protocol can also be performed with equal ef

154 st via an in situ halogenation (chlorination/bromination) protocol.

155 chlorinated drinking water, contributions to bromination rates decreased as BrCl > BrOCl > HOBr > Br2

156 That bromination rates increased with increasing [Cl(-)], [FA

157 hese additional brominating agents influence bromination rates of disinfection byproduct precursors i

158 e that species other than HOBr can influence bromination rates under conditions typical of drinking w

159 synthetic pathways as demonstrated using the bromination reaction found on the jamaicamide biosynthet

160 tic details of the isoselenazolone-catalyzed bromination reaction were revealed by (77)Se NMR spectro

161 for catalytic activity in an atroposelective bromination reaction.

162 of the isoselenazolone as a catalyst for the bromination reaction.

163 s can be used as generic bromine sources for bromination reactions giving improved yields and selecti

164 oselectivities observed in the nitration and bromination reactions in representative cases are the sa

165 ytic phosphorus(V)-mediated chlorination and bromination reactions of alcohols have been developed.

166 system can be used in both chlorination and bromination reactions of allyl amides with a variety of

167 nation, hydrofluorination, chlorination, and bromination reactions to produce saturated ROMP resins w

168 oups, was also observed in the nitration and bromination reactions.

169 ected to peptide-catalyzed, enantioselective bromination reactions.

170 as well as the development of the analogous bromination reactions.

171 aromatic substitution reaction using simple bromination reagents.

172 A two-step, bromination-reductive Heck reaction protocol was also ef

173 oefficients are consistent with the observed bromination regioselectivity.

174 to the corresponding diketone and subsequent bromination resulted in an unexpected rearrangement to a

175 an arylzinc species with ZnCl2, followed by bromination, resulted in dramatically improved yields of

176 lternative attack at the enol carbon center (bromination, selenation) have also been defined.

177 d N(2) sorption studies suggest that partial bromination serves to increase the stability of this int

178 aminopyridine/CBrCl3 system acts as an alpha-bromination shuttle by transferring Br from CBrCl3 to th

179 e EPO-H2O2-Br- system enhanced phenolic ring bromination, suggesting N-bromoamines are preferred brom

180 Fresh plant material is more susceptible to bromination than decayed litter and soil humus, due to a

181 Contrary to C-H chlorination and bromination, the direct iodination of alkanes represents

182 Free radical bromination then provided this hypercrosslinked monolith

183 erages an unusual heterocyclic N-oxide alpha-bromination to functionalize a critical C-H bond, enabli

184 at the 13-position, (iii) regioselective 15-bromination under acidic conditions, and (iv) one-flask

185 alkenes to 1,2-dibromo alkanes via oxidative bromination using HBr paired with dimethyl sulfoxide, wh

186 rt an approach to unactivated, aliphatic C-H bromination using readily available N-bromoamide reagent

187 umber of olefins were subjected to oxidative bromination using Selectfluor/KBr.

188 The kinetics of polyamide bromination were first order with respect to the concent

189 ematically varied, and rates of dimethenamid bromination were measured.

190 eriochlorins with NBS gave regioselective 15-bromination when no pyrrolic substituents were present o

191 s dimethyl sulfide and triethylamine and the bromination with Br(-).

192 ene (4) with ethyl diazoacetate, which after bromination with Br2 gave two isomeric monobromides (11

193 y(dG-d5meC) and binds to Z-DNA stabilized by bromination with high affinity and specificity.

194 O-BC) undergoes regioselective electrophilic bromination with NBS to give the 15-bromo analogue (MeO-

195 p-toluenesulfonic acid, and nuclear aromatic bromination with NBS).

196 10-mesitylchlorin (FbC-M(10)A(13)) undergoes bromination (with 1 molar equiv of NBS in THF) both in r

197 the 6-formyl derivative 19 by reduction and bromination) with the appropriate N-alkylaniline.