ライフサイエンスコーパス: bronchiolar

1 Bronchiolar abnormalities are relatively common and occu

2 protein-expressing (CE) cells in renewal of bronchiolar airway epithelium following injury.

3 of the pulmonary epithelium to bronchial and bronchiolar airway lineages occurs during the transition

4 lial cells shedding into the narrow-diameter bronchiolar airway lumens resulted in rapid accumulation

5 to significant virus-induced alterations in bronchiolar airway wall thickness and mast cell increase

6 cluding fibrosis-associated occlusion of the bronchiolar airways in all allografts of long-term survi

7 The C57BL/6 mice showed prominent lesions at bronchiolar-alveolar duct (BAD) junctions where asbestos

8 led asbestos fibers deposit initially at the bronchiolar-alveolar duct regions and alveolar macrophag

9 the peptide were clearly up-regulated at the bronchiolar-alveolar duct regions by 24 hours after the

10 reduction of growth factor expression by the bronchiolar-alveolar epithelium and lung macrophages.

11 renew and contribute descendents to both the bronchiolar and alveolar compartments.

12 eolar duct junction, BASCs were resistant to bronchiolar and alveolar damage and proliferated during

13 Single BASCs had bronchiolar and alveolar differentiation potential in lu

14 Stat3 was selectively deleted from bronchiolar and alveolar epithelial cells in Stat3(Delta

15 e most marked at 30 days and co-localized in bronchiolar and alveolar epithelial cells using an antib

16 Within 24 h, the H5N1 virus produced severe bronchiolar and alveolar lesions.

17 ion of NA alone resulted in desialylation of bronchiolar and alveolar surfaces and induction of TNF-a

18 howed that remodeling and destruction of the bronchiolar and alveolar tissue is associated with macro

19 emphysematous destruction, remodeling of the bronchiolar and alveolar tissue, and the infiltration of

20 adducin were almost exclusively expressed in bronchiolar and alveolar type II (ATII) epithelial cells

21 at both HNF-3beta and TTF-1 were detected in bronchiolar and alveolar type II cells in the human lung

22 d in cell lines and are co-expressed in lung bronchiolar and alveolar type II cells.

23 ratinocyte chemoattractant CXCL1 staining in bronchiolar and alveolar type II epithelial cells and al

24 was localized at the apical cell surface of bronchiolar and alveolar type II epithelial cells expose

25 ion, RAR and TTF-1 were colocalized in mouse bronchiolar and alveolar type II epithelial cells, the c

26 Bronchiolar and bronchioalveolar duct junction hyperplas

27 earance of plasma membrane disruptions, both bronchiolar and parenchymal, the latter to a much greate

28 was detected by in situ hybridization in the bronchiolar and peribronchiolar areas and the vascular e

29 5 hours after IA endotoxin) and later in the bronchiolar and peribronchiolar areas and vascular endot

30 The presence of skin lesions and lung bronchiolar and vascular inflammation was also dramatica

31 of virus antigen within tracheal, bronchial, bronchiolar, and alveolar epithelium.

32 for further migration of the cells into the bronchiolar area.

33 ting a functional link for BOA formation via bronchiolar cell migration.

34 nt significantly inhibited NNK-induced early bronchiolar cell proliferation on day 5.

35 e alveolar type II cells and the nonciliated bronchiolar cells (Clara cells) of the lungs; these cell

36 Although bronchiolar cells and alveolar cells are proposed to be

37 identified immunohistochemically in terminal bronchiolar cells and bronchiolized cells 7 and 14 days

38 ck gene Bmal1 (also called Arntl or MOP3) in bronchiolar cells disrupts rhythmic Cxcl5 expression, re

39 ilitating migration of Clara cells and other bronchiolar cells into the regions of alveolar injury.

40 Following injury, bronchiolar cells undergo rapid squamous metaplasia, fol

41 were assessed by the transfection of murine bronchiolar cells with a reporter containing 1.1 kb of t

42 eolar lavage fluid (BALF) and in nonciliated bronchiolar cells, alveolar type II epithelial cells, an

43 sentative of the trachea versus small airway bronchiolar cells.

44 re a stem cell population that maintains the bronchiolar Clara cells and alveolar cells of the distal

45 arker, SP-C, shows normal differentiation of bronchiolar Clara cells but a reduction in the number of

46 in lung tumors growing in wild-type mice and bronchiolar Clara cells isolated from normal mouse lungs

47 teration in the distribution and function of bronchiolar Clara cells.

48 ype 2 cells from less complete processing in bronchiolar Clara cells.

49 hat it is also secreted tonically from human bronchiolar Clara cells.

50 specific manner by the alveolar type II and bronchiolar (Clara) epithelial cells of the lung and is

51 -specific manner by the alveolar type II and bronchiolar (Clara) epithelial cells of the lung and is

52 protein (Clara) (CC16) is produced mainly by bronchiolar club cells and has been shown to have protec

53 els, reduced pulmonary eosinophilia and peri-bronchiolar collagen deposition.

54 separating (1) those disorders in which the bronchiolar disease is the predominant abnormality (prim

55 Some histopathologic patterns of bronchiolar disease may be relatively unique to a specif

56 Primary bronchiolar disorders include constrictive bronchiolitis

57 ease is the predominant abnormality (primary bronchiolar disorders) from (2) parenchymal disorders wi

58 ll proliferation were observed at 30 days in bronchiolar epithelia and at 4, 14, and 30 days in the a

59 XII protein was localized apically in human bronchiolar epithelia and basolaterally in the reabsorpt

60 tions in histologically normal bronchial and bronchiolar epithelia from lung adenocarcinomas bearing

61 in the apical cytoplasm of the bronchial and bronchiolar epithelia, in the cytoplasm of pulmonary end

62 -Flu to virion aggregation at the surface of bronchiolar epithelia.

63 buted to either type II cells or nonciliated bronchiolar epithelial (Clara) cells.

64 ial hyperplasia, and also exhibited enhanced bronchiolar epithelial and type II pneumocyte proliferat

65 However, bronchiolar epithelial cell and interstitial cell labeli

66 s strengthen the potential importance of the bronchiolar epithelial cell as a source of production of

67 ion, Stard7 expression was knocked down in a bronchiolar epithelial cell line (BEAS-2B) and specifica

68 minal airways and vessels, the appearance of bronchiolar epithelial cell necrosis, and necrotizing va

69 s developed atypical hyperplastic lesions of bronchiolar epithelial cell origin at 3 and 6 months.

70 Pulmonary nonciliated bronchiolar epithelial cells (Clara cells) and alveolar

71 These proliferating bronchiolar epithelial cells (Clara cells) may be the in

72 ted to alveolar type II epithelial cells and bronchiolar epithelial cells (Clara cells) of adult lung

73 ow that osteopontin (OPN) is up-regulated by bronchiolar epithelial cells after chrysotile asbestos e

74 asbestos caused increased numbers of distal bronchiolar epithelial cells and peribronchiolar cells i

75 me, the virus also replicated efficiently in bronchiolar epithelial cells and spread extensively in b

76 4PBA treatment of IB3-1 CF bronchiolar epithelial cells caused transiently increase

77 al antigen and nucleic acid were detected in bronchiolar epithelial cells during peak viral replicati

78 fferential display RT-PCR screen on IB3-1 CF bronchiolar epithelial cells exposed to 4PBA.

79 Nuclear STAT3 staining was induced in bronchiolar epithelial cells following naphthalene-media

80 heral epithelium and on luminal membranes of bronchiolar epithelial cells in the proximal lung, a pat

81 t PVM-positive pneumocytes and bronchial and bronchiolar epithelial cells in wt PVM- and DeltaNS1-inf

82 Knockdown of MIG-6 in H441 human bronchiolar epithelial cells increased phospho-EGFR and

83 orylated PKD (p-PKD) were observed in distal bronchiolar epithelial cells of mice inhaling asbestos.

84 ding with significantly increased numbers of bronchiolar epithelial cells staining positively for muc

85 Clara cells are non-ciliated, secretory bronchiolar epithelial cells that serve to detoxify harm

86 um, studies were performed in NCI-H441 human bronchiolar epithelial cells transfected with the human

87 rential display RT-PCR on mRNA from IB3-1 CF bronchiolar epithelial cells treated for 0-24 h with 1 m

88 GGL is also expressed in thymic lymphocytes, bronchiolar epithelial cells, pulmonary interstitial cel

89 were not associated with alveolar type II or bronchiolar epithelial cells, the cellular sites of SP-C

90 and villi of the small and large intestine, bronchiolar epithelial cells, the epidermis and hair fol

91 ty was limited to the luminal border of rare bronchiolar epithelial cells.

92 CL1 in the bronchoalveolar lavage fluid, and bronchiolar epithelial necrosis.

93 To investigate the role of bronchiolar epithelial NF-kappaB activity in the develop

94 the function of hepatocytes, intestinal and bronchiolar epithelial, and pancreatic acinar cells.

95 In marked contrast, the bronchiolar epithelium after infection with the mutant P

96 enabling them to localize near the infected bronchiolar epithelium and airway lumen to function as t

97 ip' containing a differentiated, mucociliary bronchiolar epithelium and an underlying microvascular e

98 lusters of positive cells in the respiratory bronchiolar epithelium and associated subepithelial regi

99 ated with higher viral antigen levels in the bronchiolar epithelium and greater histopathologic chang

100 ion of nuclear factor (NF)-kappaB within the bronchiolar epithelium and increased luciferase activity

101 te bronchiolitis with occasional necrosis of bronchiolar epithelium and mild to moderate peribronchio

102 inct epithelial subpopulations: the proximal bronchiolar epithelium and the distal respiratory epithe

103 Mechanisms that regulate the repair of bronchiolar epithelium are of considerable relevance for

104 interactions between molds and the bronchial/bronchiolar epithelium at the early steps after inhalati

105 nlikely to contribute to renewal of terminal bronchiolar epithelium because of the paucity of NEBs at

106 rated at areas of the H1N1pdm virus-infected bronchiolar epithelium by 1 day postinfection (dpi).

107 From E18.5 to PN20, Clara cells in the bronchiolar epithelium co-expressed Clara cell secretory

108 shape and numbers required for repair of the bronchiolar epithelium following injury.

109 ber of BrdUrd-labeled cells increased in the bronchiolar epithelium from day 2 to day 14, with the hi

110 tation, and 90 sites of normal bronchial and bronchiolar epithelium from the same surgical specimens.

111 sed in myofibroblasts and basal cells of the bronchiolar epithelium in lungs of patients with IPF, wh

112 n as regional progenitor cells to repair the bronchiolar epithelium in response to lung damage.

113 dentified putative HFH-4 target genes in the bronchiolar epithelium including the clara cell secretor

114 spores in vivo cannot explain the bronchial/bronchiolar epithelium invasion observed in some invasiv

115 Surprisingly, K-ras activation in the bronchiolar epithelium is associated with a robust infla

116 Bronchiolar epithelium is postulated to play a critical

117 CR analysis for levels of c-jun and c-fos in bronchiolar epithelium isolated by laser capture microdi

118 of mucus and increased mClca3 protein in the bronchiolar epithelium of asbestos-exposed mice at all t

119 f 25 cases of DAD but was only identified in bronchiolar epithelium of control lungs.

120 0 and MIG receptor CXCR3 was detected in the bronchiolar epithelium of preterm lambs by immunostainin

121 ein expression was detected diffusely in the bronchiolar epithelium of rats receiving Ad5-HO-1, as as

122 e that activation of Wnt/beta-catenin in the bronchiolar epithelium of the adult mouse lung does not

123 ivin expression was restricted to the distal bronchiolar epithelium of the lung and neural-crest-deri

124 e small intestine, white pulp of the spleen, bronchiolar epithelium of the lung, myocardium, adrenal

125 e splenic reticuloendothelial system and the bronchiolar epithelium of the lung.

126 in the lamina propria of the gut and in the bronchiolar epithelium of the lungs.

127 otype, resulting in a phenotypic switch from bronchiolar epithelium to the highly proliferative dista

128 Whereas nearly complete repair of the bronchiolar epithelium was observed in control mice with

129 oss of alveolar septae, and sloughing of the bronchiolar epithelium were observed in Stat3(DeltaDelta

130 in the apical cytoplasm of the bronchial and bronchiolar epithelium yet no staining was seen in the a

131 in the apical cytoplasm of the bronchial and bronchiolar epithelium yet robust staining was seen in t

132 ent at alveolar duct bifurcations and within bronchiolar epithelium, alveolar macrophages, and the vi

133 and eotaxin were predominantly expressed in bronchiolar epithelium, in contrast to distal regions of

134 onal sites as well as in the esophagus, lung bronchiolar epithelium, kidney glomerular epithelium, ol

135 e of foci of hyperproliferative cells in the bronchiolar epithelium, particularly in the bronchiolalv

136 t virus showed widespread destruction of the bronchiolar epithelium, with extensive distribution of v

137 s of goblet cell metaplasia in bronchial and bronchiolar epithelium.

138 Viral RNA localized to bronchial and bronchiolar epithelium.

139 B) and contribute to renewal of the proximal bronchiolar epithelium.

140 al organization, or organelle composition in bronchiolar epithelium.

141 nd exhibits abundant expression in the adult bronchiolar epithelium.

142 e transcriptional regulation of genes in the bronchiolar epithelium.

143 anges and epithelial necrosis of bronchi and bronchiolar epithelium.

144 tive NF-kappaB pathway, respectively, in the bronchiolar epithelium.

145 STAT3 signaling pathway during repair of the bronchiolar epithelium.

146 iated with severe injury of the alveolar and bronchiolar epithelium.

147 club cells, a major component of the murine bronchiolar epithelium.

148 markers of cell cycle reentry, in the distal bronchiolar epithelium.

149 s perinatal expression was restricted to the bronchiolar epithelium.

150 ning and fibrosis may be caused by increased bronchiolar expression of cytokines such as TGF-beta 1 i

151 distal epithelial progenitors first produce bronchiolar-fated and subsequently alveolar-fated progen

152 Treated rats had fewer proliferating bronchiolar fibroblasts, as detected by bromodeoxyuridin

153 ha is an important mediator of virus-induced bronchiolar fibrosis, and 3) TNF-alpha has a critical ro

154 important regulatory event in virus-induced bronchiolar fibrosis, pulmonary TNF-alpha mRNA and prote

155 nza type I (Sendai) virus is associated with bronchiolar fibrosis.

156 sistant (Fischer 344; F344) to virus-induced bronchiolar fibrosis.

157 terestingly, alveolar gas NO (estimated from bronchiolar gases at end-expiration) was near zero, sugg

158 synthesis in the static lung was measured in bronchiolar gases during an expiratory breath-hold in no

159 ARS-CoV infection demonstrated bronchial and bronchiolar hyperplasia and perivascular cuffing in ferr

160 al for the development of K-Ras(G12V)-driven bronchiolar hyperplasias and adenomas, but not for the g

161 -induced structural abnormalities, including bronchiolar hypoplasia, alveolar dysplasia, bronchiolar

162 al sequelae, the IFN-gamma group having less bronchiolar inflammation (p = 0.025) and fibrosis (p = 0

163 on lung transplantation, is characterized by bronchiolar inflammation and tissue remodeling.

164 was concordant with increased bronchial and bronchiolar inflammation.

165 fficient to suppress airway hyperreactivity, bronchiolar inflammatory infiltrate and allergen-specifi

166 Previous studies of naphthalene-induced bronchiolar injury and repair in the mouse have shown th

167 We compared acute bronchiolar injury and repair in three strains of mice u

168 Various histopathologic patterns of bronchiolar injury have been described and have led to c

169 immunochemically during repair of this acute bronchiolar injury.

170 rom (2) parenchymal disorders with prominent bronchiolar involvement and (3) bronchiolar involvement

171 th prominent bronchiolar involvement and (3) bronchiolar involvement in large airway diseases.

172 Prominent bronchiolar involvement may be seen in several interstit

173 spiratory Distress Syndrome (CARDS) toxin in bronchiolar lavage fluid (BALF) and lung.

174 the total number of cells and macrophages in bronchiolar lavage fluid (BALF), as well infiltrating in

175 -dependent inhibition of eosinophilia in the bronchiolar lavage fluid, when compound A was given intr

176 ung tissue substantiated the findings in the bronchiolar lavage fluid.

177 rom fungi and bacteria in DNA extracted from bronchiolar lavage samples and oropharyngeal wash.

178 The clinical relevance of a bronchiolar lesion is best determined by identifying the

179 tic foci (subpleural, peri-vascular and peri-bronchiolar lesions) and destruction of alveolar archite

180 f BOS and is characterized by a perivascular/bronchiolar leukocyte infiltration.

181 isk factor, is characterized by perivascular/bronchiolar leukocyte infiltration.

182 ow end-expiratory lung volume, mainly at the bronchiolar level.

183 A levels (P < 0.05) and increased numbers of bronchiolar macrophages and fibroblasts expressing TNF-a

184 BN rats also had greater numbers of bronchiolar macrophages expressing TGF-beta 1 protein th

185 t by increased TGF-beta 1 gene expression by bronchiolar macrophages in genetically susceptible indiv

186 bronchiolar mural fibrosis, and increases in bronchiolar mast cells, were associated with virus-induc

187 bronchiolar hypoplasia, alveolar dysplasia, bronchiolar mural fibrosis, and increases in bronchiolar

188 rmalities were most strongly associated with bronchiolar mural thickening and fibrosis as well as wit

189 We also determined whether bronchiolar mural thickening and fibrosis may be caused

190 n multiorgan system cGVHD model that induces bronchiolar obliterans (BO).

191 The factors that regulate bronchiolar regeneration after Clara cell injury are not

192 ithelial cell interfaces in the alveolar and bronchiolar regions of the lung parenchyma and was assoc

193 proliferative population in initial terminal bronchiolar repair and include a population of label-ret

194 RP-expressing neuroendocrine cells reside in bronchiolar SCPC niches, we hypothesized that the glandu

195 to type I and type II pneumocytes as well as bronchiolar secretory cells following transplantation to

196 ytes and abundant expression in vascular and bronchiolar smooth muscle cells.

197 achments to the outer wall of small airways: bronchiolar smooth muscle is increased also.

198 r prostaglandin E(2) (PGE(2)) production and bronchiolar smooth muscle relaxation.

199 observed in the respiratory epithelium, the bronchiolar smooth muscle, and the pulmonary vasculature

200 rk, bacteria and hemorrhages in alveolar and bronchiolar spaces, and hypoxic foci in the lung (endoth

201 The bronchial/bronchiolar spores decreased between 1 and 18 hours afte

202 alysis revealed a higher number of bronchial/bronchiolar spores for A. fumigatus than L. corymbifera.

203 tive contributions of progenitor (Clara) and bronchiolar stem cells to epithelial maintenance and rep

204 We hypothesized that a reduced potential for bronchiolar stem-cell (Clara cell)-related repair in the

205 ed 10-fold in the lung tissue and 22-fold in bronchiolar tissue as compared with their controls.

206 nhibited asbestos-induced AP-1 activation in bronchiolar tissue.

207 The mechanisms controlling this bronchiolar-to-alveolar developmental transition remain

208 ells, lymphocytes, and eosinophils, into the bronchiolar wall.

209 ng TGF-beta 1 protein that were localized in bronchiolar walls at 10, 14, and 30 d after inoculation.

210 A human bronchiolar xenograft model was employed to investigate

211 Inoculation of human bronchiolar xenografts revealed a significant reduction