ライフサイエンスコーパス: brother

1 X, which was absent from his mildly affected brother.

2 h three affected brothers and one unaffected brother.

3 VL mutation in the sisters' father and older brother.

4 to rapidly progressive encephalopathy in her brother.

5 stem-cell transplant from his HLA-identical brother.

6 s lobules VI and VII, in comparison with his brother.

7 No foveal cones were detected in the older brother.

8 individual who also had a deceased, affected brother.

9 idney transplant from her HLA-haploidentical brother.

10 on average twice as many offspring as either brother.

11 siblings but not their unaffected parents or brother.

12 and p.A334T) in the proband and her affected brother.

13 ; one from his mother and the other from his brother.

14 warmth sensation in the proband, father and brother.

15 backcross males compared with their fertile brothers.

16 iblings, but there was no association within brothers.

17 omen (n = 69) who were raised with 1 or more brothers.

18 infancy died sooner than their less fearful brothers.

19 the cause of a neurological disorder in two brothers.

20 persistent smokers than their normal-control brothers.

21 sely related workers value nephews more than brothers.

22 isters or a greater number of older maternal brothers.

23 es in the individual odors of their familiar brothers.

24 adic case, and one kindred with two affected brothers.

25 e associated with pachydermoperiostosis in 3 brothers.

26 reased with the number of additional healthy brothers.

27 fixed-effects regression for comparisons of brothers.

28 ng and a mate and his son killing two of his brothers.

29 for fixed parental characteristics shared by brothers.

30 0.6, 1.2) shorter than were their singleton brothers.

31 with CAH scored lower than their unaffected brothers.

32 Retinal images were obtained from two brothers (13 and 15 years) and two unrelated subjects, o

33 arkinsonism and 250 presumed unaffected twin brothers, 193 twins with PD were identified (concordance

34 95% CI, 5.9- to 14-fold) was higher than in brothers (4.5-fold; 95% CI, 2.9- to 6.7-fold) or unlike-

35 the family relationship, and were higher in brothers (64.0; P = .04), fathers (42.9; P = .004), and

36 %), and daughters (9.8%)] than in male FDRs [brothers (7.8%), fathers (3.7%), and sons (0%)].

37 rother B received unfractionated marrow from brother A after reduced-intensity conditioning with cycl

38 Both brothers are clinically well; brother A is in a fully immunologically reconstituted st

39 Brother A received a 4/6-matched, HLA DRbeta1-identical

40 We have also found in two brothers a heterozygous mutation, an A to G transition t

41 Here we describe somatic mosaicism in two brothers affected with Wiskott-Aldrich syndrome (WAS).

42 We have identified two brothers (ages 8 and 10 years) with very mild proximal w

43 y study of this mutation, we found his elder brother also carried this mutation but did not have psyc

44 In addition, the brother also exhibited localized aggressive periodontiti

45 Triplets of brothers also fought less with each other, courted femal

46 A brother and a surviving sister are heterozygous; each be

47 d genetic interference experiments show that Brother and Big brother are redundant and function toget

48 sults firmly establish the importance of the Brother and Big brother proteins for the biological acti

49 Brother and Big brother were isolated as Runt-interactin

50 patterns in Drosophila embryos revealed that Brother and Big-brother are likely to interact with runt

51 ntified two Drosophila genes, referred to as Brother and Big-brother, that have substantial sequence

52 e, and two genes encoding beta-subunits, Big brother and Brother, have been previously identified.

53 sonance imaging scans were obtained for each brother and compared with the scans of 5 age- and sex-ma

54 study, a girl living in Lima, Peru, and her brother and dog were diagnosed with Cryptosporidium cani

55 ation of heterodimeric complexes between Big brother and either Lozenge or Runt.

56 The patient's brother and father reported similar complaints including

57 vealed that the proposita and her unaffected brother and father were heterozygous for this mutation.

58 A brother and sister developed a previously undescribed co

59 drought, the lineage was reduced to a single brother and sister, who bred with each other.

60 lcohol-dependent probands, 49.3% to 50.1% of brothers and 22.4% to 25.0% of sisters were alcohol depe

61 than for male family members (13% lower for brothers and 9% lower for fathers).

62 The difference in BMI was similar within brothers and between nonsiblings.

63 state cancer in a family with three affected brothers and one unaffected brother.

64 e or remain in their natal group, (ii) adult brothers and sisters often co-reside, and (iii) most ind

65 Brothers and sons of affected men have a 2-3-fold increa

66 a reduced number of healthy cones in the two brothers and the adult female.

67 from a quartet consisting of two BD-affected brothers and their two unaffected parents.

68 ed with an increased risk of hypertension in brothers and unaffected sisters, whereas an increased ri

69 The proband, his brother, and his mother have a novel missense mutation (

70 the functional homology of the Brother, Big-brother, and PEBP2/CBF beta proteins and demonstrated th

71 nfamiliar male faces than were women without brothers, and both groups found self-resemblance to be e

72 oband, c.2159G>C [p.C720S] in the 2 affected brothers, and c.1952G>A [p.R651Q] in the third proband.

73 ophila embryos revealed that Brother and Big-brother are likely to interact with runt in vivo and fur

74 erence experiments show that Brother and Big brother are redundant and function together with Runt du

75 Both brothers are clinically well; brother A is in a fully im

76 Two Serbian sisters and two German brothers are described.

77 This substitution was absent from the brothers' asymptomatic parents, suggesting that it arose

78 Brother B experienced mixed-donor (i.e. original UCB) ch

79 Two years later, brother B received unfractionated marrow from brother A

80 ase is activated by two RING E3 ligases, Big Brother (BB) and DA2, which are subsequently cleaved by

81 tors (females growing up with similarly aged brothers) because females born with a male co-twin have

82 grandchildren; and (iv) siblings, especially brothers, benefit when their opposite-sex siblings marry

83 ies confirmed the functional homology of the Brother, Big-brother, and PEBP2/CBF beta proteins and de

84 wild-type Brother proteins, suggesting that Brother/Big brother dosage is limiting in this developme

85 e interval [CI], 0.35 to 1.52) than in their brothers born before their mother was diagnosed with dia

86 In the third kindred, affected brothers both have an intragenic 13-bp duplication resul

87 s and their problem or pathological gambling brothers, but adjusted co-twin analyses resulted in stat

88 would sacrifice his own life for two of his brothers, but not for less.

89 Her brother (Bx) and her mother (Mx) were evaluated and diag

90 ect is driven by younger, rather than older, brothers, consistent with the proposal that only younger

91 wing routine immunization, whereas an infant brother died after a 2-d febrile illness from an unknown

92 a progressive neurological disorder and his brother died in infancy of Leigh syndrome.

93 wever, first his father and then his younger brother died, leaving him and his older brother responsi

94 A grandson of one of the brothers died of a severe Aspergillus infection secondar

95 t the impact of kinship is limited; paternal brothers do not selectively affiliate and cooperate, pro

96 rother proteins, suggesting that Brother/Big brother dosage is limiting in this developmental context

97 The proband and her affected brother exhibited unusual, previously unreported, findin

98 Here, we studied two infertile brothers exhibiting normal sperm morphology but complete

99 Recently, the brother experienced recurrent thrombosis after cryopreci

100 In vitro experiments indicate that Brother family proteins regulate the DNA binding activit

101 the fraternal birth order effect (more older brothers for homosexual men).

102 In the younger brother, foveal cones were enlarged with low density (pe

103 A proband and his 2 affected brothers from a family segregating X-linked recessive CS

104 We conducted exome sequencing of two brothers from a non-consanguineous relationship who pres

105 Big brother functions with Lozenge during cell fate specific

106 t, we examine the effects of expression of a Brother fusion protein homologous to the dominant negati

107 as used to isolate mutant alleles of the Big brother gene.

108 the mean-corrected cross product between the brothers' Gleason scores on the estimated proportion of

109 mol/L) and well-controlled hypertension; her brother had a stroke in his 30s.

110 His brother had aplastic anemia in the course of his EBV inf

111 ther had died at the 65 years of age and the brother had died at 75 years of age).

112 The second brother had mild exercise intolerance, normal muscle his

113 The proband and an affected brother had progressive aphasic dementia, leukoencephalo

114 Her 62-year-old brother had progressive weakness, fasciculations, hyperr

115 Both the proband and her affected brother had RP, PAP, mild mental retardation, morbid obe

116 ears of age, their then-asymptomatic younger brother had the same bilateral fleck deposits with minim

117 stic spectrum disorder in which two affected brothers had a point mutation that substituted a Cys for

118 In the second family, 2 brothers had B lymphocytopenia and immunoglobulin defici

119 s of gay sons, particularly those with older brothers, had significantly higher anti-NLGN4Y levels th

120 studied mitochondrial function in vivo in 2 brothers harboring the mitochondrial DNA A3243G mutation

121 urrent infections, while the elder, affected brother has normal levels of IgG and IgM and very few in

122 enes encoding beta-subunits, Big brother and Brother, have been previously identified.

123 taller sibling): >/=10 cm difference between brothers hazard ratios=0.69 (95% confidence interval, 0.

124 pleen and severe thrombocytopenia; her older brother, homozygous for the same 1226G glucocerebrosidas

125 he estimated proportion of alleles shared by brothers identical by descent at each marker location.

126 system: (i) G237S in an nIHH female and a KS brother; (ii) (P722H and N724K) in an nIHH male missing

127 Just as the Wright brothers implemented controls to achieve stable airplane

128 GK exon 17 was deleted in both brothers, implicating additional factors in causation of

129 affiliate and cooperate with their maternal brothers in several behavioral contexts.

130 with the mean birth weight of all singleton brothers in the family or in a twin compared with the ma

131 se associated with the children's fathers or brothers-in-law.

132 The index case subjects were two brothers, individuals 1 and 2, who presented with osteop

133 Expression studies show that Big brother is a nuclear protein that co-localizes with both

134 9 (95% CI 1.2-3.0); for prostate cancer in a brother, it was 3.0 (95% CI 1.8-4.9).

135 he occurrence of FIM in a male cousin of the brothers led to the XLP diagnosis.

136 However, associations among brothers may be vulnerable to invasion by minorities of

137 , including autism, and their closest-in-age brothers (N=100 pairs), and 3) children with psychopatho

138 unrelated to autism and their closest-in-age brothers (N=45 pairs).

139 amilies and their closest in age nonautistic brothers (N=49 pairs); 2) children with any pervasive de

140 ry of this cancer in either their fathers or brothers (odds ratio (OR) = 2.3, 95% confidence interval

141 lated by association with a related protein, Brother of ataxin-1 (Boat).

142 lated, down-regulated by oncogenes (CDO) and Brother of CDO (BOC) are the closest mammalian relatives

143 The transmembrane protein Brother of Cdo (Boc) has been implicated in Shh-mediated

144 olecule downregulated by oncogenes (CDO) and brother of CDO (BOC), actively distribute and co-localiz

145 gal projection neurons and the Shh receptor, Brother of CDO (Boc), is expressed in local and callosal

146 Drosophila, Interference hedgehog (Ihog) and Brother of ihog (Boi) are two conserved and redundant tr

147 y encoded by interference hedgehog (ihog) or brother of ihog (boi).

148 nce hedgehog), or of its close relative Boi (Brother of Ihog), is absolutely required for Hh biologic

149 o-receptors Interference hedgehog (Ihog) and Brother of Ihog, suggesting that Shf regulates short-ran

150 BROTHER OF LUX ARRHYTHMO (BOA) is a GARP family transcri

151 ls or wild-type iPSCs derived from a healthy brother of one of the LEOPARD syndrome patients.

152 tragenic DNA methylation-mediated binding of Brother of Regulator of Imprinted Sites (BORIS) at the a

153 CFL, a paralog of CTCF, also known as BORIS (brother of regulator of imprinted sites), is a testis-ex

154 ence similarity searching that we have named brother of rhomboid (brho).

155 e additional case identified was in the twin brother of the nine-year-old patient.

156 CCCTC-binding factor (CTCF) and its paralog brother of the regulator of imprinted sites (BORIS) are

157 Brother of the Regulator of Imprinted Sites (BORIS) is a

158 gene and to be regulated by another CTA, the Brother of the Regulator of Imprinted Sites (BORIS) tran

159 Brother of the regulator of imprinted sites (BORIS) was

160 he paralogous zinc-finger proteins--CTCF and brother of the regulator of imprinted sites (BORIS), dir

161 BORIS (brother of the regulator of imprinted sites) is an insul

162 The CTCF paralog BORIS (brother of the regulator of imprinted sites) is an insul

163 shown that the CTCF paralogous gene, BORIS (brother of the regulator of imprinted sites) is expresse

164 ic paralogue of CCCTC-binding factor, BORIS (brother of the regulator of imprinted sites).

165 We named this gene BORIS for Brother of the Regulator of Imprinted Sites.

166 ich are named sister of tout-velu (sotv) and brother of tout-velu (botv), and encode Drosophila homol

167 Five brothers of another family had arrhythmia and heart bloc

168 redictors of antisocial behavior, 38 younger brothers of convicted delinquents provided platelet samp

169 A series of 34 younger brothers of convicted delinquents underwent standardized

170 subsequently suffered greater mortality than brothers of equivalent quality, which reared larvae with

171 By contrast, the sons and brothers of male patients had a higher prevalence of the

172 Brothers of men with TGCT have an 8-10-fold risk of deve

173 Brothers of patients with schizophrenia and autism showe

174 d age-adjusted risk of prostate cancer among brothers of probands, compared with their fathers (relat

175 rove the reporting of adult deaths among the brothers of respondents.

176 Moreover, the brothers of women with PCOS have insulin resistance and

177 in control design, which matches sisters and brothers on genetic and familial-environmental backgroun

178 Two adult brothers, one documented to have methylmalonic acidemia

179 These were three affected brothers, one with keratoconus, all with CRB1 mutations.

180 isk of cardiovascular events was observed in brothers only.

181 did not alter the association either within brothers or between nonsiblings.

182 teers answered questions (e.g., "Do you have brothers or sisters?") in the fMRI scanner, by selective

183 R=3.1, 1.5-6.7, p=0.004) but not an affected brother (OR=1.1, 0.6-2.1, p=0.80).

184 inkage analysis of 80 candidate genes in 201 brother pairs affected with prostatic adenocarcinoma.

185 ins 833 subjects from 3 independent cohorts: brother pairs and singletons with and without a history

186 hout a history of inhibitors, as well as 104 brother pairs discordant for inhibitor status.

187 Subjects were older nuns, priests and brothers participating in the Religious Orders Study who

188 .8, 95% confidence interval: 1.6, 2.0) while brothers' partners were not.

189 His younger brother, patient 3, also had GK deficiency, but so far h

190 roband performance predicted both sister and brother performance, an effect that was most powerfully

191 The affected brother presented with irregular patterns of autofluores

192 One brother presented with recurrent strokes and had a mitoc

193 Two brothers presented with XLI.

194 d DNA and that this bending is influenced by Brother protein family members, supporting the idea that

195 f Runt and Lozenge, and further suggest that Brother protein function is not restricted to enhancing

196 he nuclear localization and stability of Big brother protein is mediated through the formation of het

197 demonstrate functional interactions between Brother proteins and Runt domain proteins in Drosophila.

198 d that the conserved regions of the Runt and Brother proteins are required for their heterodimeric in

199 ation in Runt that disrupts interaction with Brother proteins but does not affect DNA binding activit

200 ablish the importance of the Brother and Big brother proteins for the biological activities of Runt a

201 To investigate further the requirements for Brother proteins in Drosophila development, we examine t

202 nt are suppressed by expression of wild-type Brother proteins, suggesting that Brother/Big brother do

203 intermittent palpitations and syncope in his brother raised suspicion for catecholaminergic polymorph

204 where land is inherited, the number of elder brothers reduces a man's agricultural productivity, marr

205 nger brother died, leaving him and his older brother responsible for a suddenly impecunious family as

206 e sequencing of Btk gene transcripts in both brothers revealed no additional mutations to account for

207 o died of typhus two years after his younger brother's death, leaving his greatest scientific achieve

208 t hematopoietic cells derived from the older brother's marrow engrafted without causing GVHD, suggest

209 The affected brothers shared a missense mutation in APP, resulting in

210 stensen et al. recently reported two anosmic brothers sharing a CNGA2 truncating variant.

211 In a second family, 2 brothers showed bilateral microcornea, childhood catarac

212 spiratory failure and death of a 15-year-old brother (sibling 1) and a 13-year-old sister (sibling 2)

213 C57BL6 with SKH-1 hairless mice, followed by brother-sister cross to get F2 homozygous mutant (hairle

214 families were generated by one generation of brother-sister mating and compared to an outbred control

215 lysis on a cohort of F(2) mice, offspring of brother-sister mating between (high pathology CBA x low

216 igh levels of inbreeding because of frequent brother-sister mating in nature; therefore, diploid male

217 CBA/J propagated only by brother-sister mating maintained seven of eight polymorp

218 our colony after more than 20 generations of brother-sister mating.

219 om the outbred stock by eight generations of brother-sister mating.

220 nal backcrosses to LG before being inbred by brother-sister mating.

221 e seven additional generations of sequential brother-sister or father-daughter matings (termed G7).

222 Families with brother-sister sib-pairs showed a peak NPL of 3.46 ( P =

223 We describe the case of 2 brothers, sons of first cousins, with lifelong history o

224 In these 3 brothers strongly reduced NADPH oxidase function was fou

225 (Walt Disney Co, MGM/United Artists, Warner Brothers Studios, Universal Studios, and 20th Century Fo

226 Using data from 1,306 black MSM in the BROTHERS Study (2009-2010) in the United States, we exam

227 etected in semen), but absent in his fertile brother, suggesting that the USP9Y mutation caused sperm

228 similar to her severely affected 8-year-old brother, suggesting that unknown mechanisms may partiall

229 that gay men have a greater number of older brothers than do heterosexual men.

230 authors selected the 1,721 sibships of full brothers that included at least 1 male born in a single

231 ophila genes, referred to as Brother and Big-brother, that have substantial sequence homology with PE

232 Given 1 affected brother, the lifetime FRR was 5.88 (95% CI: 4.70, 7.36),

233 Given 2 affected brothers, the FRR was 21.71 (95% CI: 8.93, 52.76).

234 Females exposed to groups of three brothers unrelated to the female had higher lifetime rep

235 NA derived from the proband and her affected brother, using a nonisotopic RNase cleavage assay, revea

236 An affected brother was also homozygous for the deletions, whereas a

237 ections and severe skin disease, whereas the brother was fairly asymptomatic but had bronchiectasis.

238 Another asymptomatic brother was heterozygous for the deletion, whereas both

239 nce after 2 wk off treatment in the affected brothers was -30.4+/-1.2 mV (values mean+/-SD, lumen-neg

240 00-mg/d difference in dietary sodium between brothers was associated with a 10.3% difference in CFR a

241 Informing brothers was more likely when BRCA1/2 was inherited thro

242 of eldest and younger children with an older brother were both within the range of the biologically n

243 Brother and Big brother were isolated as Runt-interacting proteins and a

244 g progressive immunoglobulin deficiencies, 3 brothers were examined for recurrent respiratory infecti

245 HD-causing genes, we found that two affected brothers were heterozygous for a missense variant in the

246 Women with brothers were less attracted to self-resembling, unfamil

247 n by minorities of unrelated males: when two brothers were matched with an unrelated male, the unrela

248 rough paternal lineage (P = .04), but 29% of brothers were not informed.

249 38 families in which three or more affected brothers were reported, the LOD score was 3.83 (P = 0.00

250 In contrast, all 6 clones from the brother who did not develop an inhibitor were T(H)1-pola

251 nd females and alleles from a family of five brothers who are methylation mosaics and are affected to

252 ts from the young woman and two of the three brothers who died were available for our histological ex

253 importance of WASp was investigated in 2 WAS brothers who show no detectable expression of WASp.

254 ure and function were found in the proband's brother, who had 0.0 logMAR visual acuity.

255 were also isolated from his multiply infused brother, who has not developed a clinically significant

256 ed to examination of her mother, father, and brother, who were mildly symptomatic; all 3 were subsequ

257 segment hepatic graft was procured from her brother, whose body weight was similar to hers.

258 ed of systemic lupus erythematosus and for a brother with arthritis.

259 His brother with low-to-moderate-affinity IgG1 and IgG3 also

260 was highest among individuals who reported a brother with NHL (OR = 2.8; 95% CI = 1.6-4.8) and was co

261 with cleft lip/palate and missing teeth, his brother with nIHH, and his father with delayed puberty.

262 o be increased among men who had a father or brother with prostate cancer.

263 The affected boy had an unaffected brother with the same haplotype around the DKC1 gene and

264 We studied platelet inhibition by NO in two brothers with a cerebral thrombotic disorder.

265 We identified 2 brothers with a homozygous mutation in CD27 leading to a

266 quencing to study a family with two affected brothers with bilateral A/M and a simplex case with bila

267 Here, we describe two brothers with classical ASD who carry a single amino-aci

268 s scanning light ophthalmoscopy imaging of 2 brothers with early STGD1 and their unaffected parents w

269 hannel activity in cystic fibrosis) in three brothers with genetically proven Liddle's syndrome, thei

270 PBMC were isolated from two brothers with GS, their parents, and healthy control sub

271 Here, we describe two brothers with hematopoietic and immunologic symptoms rem

272 re higher in twins with lower CFR than their brothers with higher CFR (p < 0.05).

273 3A, causes HPS in the pearl mouse and in two brothers with HPS-2.

274 oint mutation in semaphorin 3E (SEMA3E) in 2 brothers with Kallmann syndrome (KS), which causes inher

275 y mutations in semaphorin 3E (SEMA3E) in two brothers with Kallmann syndrome.

276 Two brothers with KS and their sister with nIHH harbored a h

277 ght blindness caused by mutations in GRM6, 2 brothers with Oguchi disease caused by mutations in GRK1

278 nducted a genomewide linkage analysis of 513 brothers with PCa, using the Gleason score, which reflec

279 Analysis of a genome screen of 504 brothers with prostate cancer (CaP) who were from 230 mu

280 H-specific hormone resistance in these three brothers with pseudohypoparathyroidism type Ib.

281 n reaction to amplify genomic DNA from three brothers with pseudohypoparathyroidism type Ib.

282 We describe 3 brothers with severe G6PD deficiency and susceptibility

283 rst use of hepatocyte transplantation in two brothers with severe inherited coagulation factor VII de

284 nd in exon 10 of the ABC7 gene in 2 affected brothers with XLSA/A.

285 ommon environmental factors by comparison of brothers within a twin pair, a twin with a 1-g higher AL

286 had a 49% lower low-frequency HRV than their brothers without PTSD (p<.001).