ライフサイエンスコーパス: brown adipose tissue

1 lar, perirenal, epididymal, subcutaneous and brown adipose tissue.

2 is, thermogenesis, and browning of white and brown adipose tissue.

3 th increased noradrenaline concentrations in brown adipose tissue.

4 marker gene, as a cold-responsive protein of brown adipose tissue.

5 and that of the rest of the body, including brown adipose tissue.

6 rotein 1 (UCP1) expression in both white and brown adipose tissue.

7 in-1 and mitochondrial oxygen consumption in brown adipose tissue.

8 a3-adrenoceptor-stimulated glucose uptake in brown adipose tissue.

9 turnal locomotor activity, and activation of brown adipose tissue.

10 r levels of sympathetic neurotransmitters in brown adipose tissue.

11 sed activation of the thermogenic program in brown adipose tissue.

12 e by increasing energy-utilizing thermogenic brown adipose tissue.

13 c-1alpha and uncoupling protein 1 (Ucp-1) in brown adipose tissue.

14 re and to avoid fluorodeoxyglucose uptake in brown adipose tissue.

15 strogen-related receptor alpha (ERRalpha) in brown adipose tissue.

16 ion recovers metabolic activity of offspring brown adipose tissue.

17 ochondrial function, energy expenditure, and brown adipose tissue.

18 n of uncoupling protein 1 (UCP1) and UCP3 in brown adipose tissue.

19 anocortins, modelled on the brain control of brown adipose tissue.

20 nd their production of IL-4 in the white and brown adipose tissues.

21 al vascular fraction (SVF) of both white and brown adipose tissues.

22 the transcription factor Yin Yang 1 (YY1) in brown adipose tissue activates the canonical thermogenic

23 ature regimens and tested characteristics of brown adipose tissue activation.

24 ble mechanism for obesity-mediated defective brown adipose tissue activation.

25 Both peptides have opposite effects on the brown adipose tissue activity through thermoregulatory n

26 ating T3 and T4 levels, Ucp1 expression, and brown adipose tissue activity, demonstrating that DNP-me

27 Brown adipose tissue also expresses two novel exon 1b-de

28 tion that adult humans have heat-dissipating brown adipose tissue, an important contributor to energy

29 rough beta3-adrenergic receptors to activate brown adipose tissue and by 'browning' white adipose tis

30 es cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis.

31 Surgical ablation of brown adipose tissue and functional knockdown of Ucp1 al

32 preadipocytes and precursor stem cells into brown adipose tissue and increased mitochondrial respira

33 l increased expression of UCP-1 and UCP-3 in brown adipose tissue and increased UCP-3 and inhibition

34 lated to increased thermogenic activation of brown adipose tissue and induction of browning in WAT an

35 CoA thioesterase that is highly expressed in brown adipose tissue and is regulated by both ambient te

36 , and downregulation of oxidative enzymes in brown adipose tissue and oxidative and lipogenic genes i

37 dh1 expression decreased 80-90% in liver and brown adipose tissue and Rdh10 expression was decreased

38 in body temperature due to an inhibition of brown adipose tissue and shivering thermogenesis that is

39 expression and mitochondrial dysfunction in brown adipose tissue and skeletal muscle.

40 ryos exhibit increased mass of interscapular brown adipose tissue and subcutaneous white adipocytes,

41 n levels affecting the oxidative capacity of brown adipose tissue and thus non-shivering thermogenesi

42 y increased rates of fatty acid oxidation in brown adipose tissue and up-regulation of genes that pro

43 n TAp63-null mouse embryonic fibroblasts and brown adipose tissues and by tumor necrosis factor alpha

44 essed in the mitochondrial inner membrane of brown adipose tissues and has an important role in heat

45 a circulating protein secreted by white and brown adipose tissues and the liver.

46 s little uptake in the lungs, fat (including brown adipose tissue), and muscle.

47 uced intrathymic lipid, increased perithymic brown adipose tissue, and elevated thymic T-cell export

48 oxygen consumption in white adipose tissue, brown adipose tissue, and hepatocytes.

49 normal body temperature, Ucp1 expression in brown adipose tissue, and muscle and liver fatty acid ox

50 steatosis, lower levels of lipid droplets in brown adipose tissue, and smaller white adipocytes after

51 g protein-1 expression was attenuated in the brown adipose tissue, and there was reduced browning of

52 dies identify mitochondrial ROS induction in brown adipose tissue as a mechanism that supports UCP1-d

53 The importance of brown adipose tissue as a site of nonshivering thermogen

54 ShK-186 therapy activated brown adipose tissue as evidenced by a doubling of gluco

55 ta is abundantly expressed in both white and brown adipose tissue as well as the brain, the contribut

56 roton transport mechanism of this protein in brown adipose tissues as well as structure-function rela

57 that plays critical roles in development of brown adipose tissue, as well as maintenance of adult he

58 Both brown adipose tissue (BAT) (i.e. uncoupling protein 1 (U

59 adipokine/cytokine, is a novel regulator of brown adipose tissue (BAT) activation by modulating the

60 Brown adipose tissue (BAT) activation via cold exposure

61 reases body adiposity through attenuation of brown adipose tissue (BAT) activity, a major contributor

62 Brown adipose tissue (BAT) activity, WAT browning and en

63 rgy dissipation in association with enhanced brown adipose tissue (BAT) activity.

64 Brown adipose tissue (BAT) acts in mammals as a natural

65 Brown adipose tissue (BAT) and beige adipose tissue comb

66 simultaneous PET/MR imaging for identifying brown adipose tissue (BAT) and discriminating it from wh

67 that orchestrates lipoprotein processing in brown adipose tissue (BAT) and hepatic conversion of cho

68 ption factor Hlx is selectively expressed in brown adipose tissue (BAT) and iWAT, and is translationa

69 l neural substrate for the inhibition of rat brown adipose tissue (BAT) and shivering thermogenesis b

70 ulation of thermogenic capacity in classical brown adipose tissue (BAT) and subcutaneous inguinal (SC

71 expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) and subcutaneous WAT.

72 nesis and, upon cold exposure, is induced in brown adipose tissue (BAT) and subcutaneous white adipos

73 data suggest a negative correlation between brown adipose tissue (BAT) and the degree of coronary at

74 f a synthesis-free method for PET imaging of brown adipose tissue (BAT) and translocator protein 18 k

75 vascular endothelial growth factor (VEGF) in brown adipose tissue (BAT) and white adipose tissue (WAT

76 ssion of the NP clearance receptor (Nprc) in brown adipose tissue (BAT) and white adipose tissue (WAT

77 ound that Id1 protein is highly expressed in brown adipose tissue (BAT) and white adipose tissue (WAT

78 Brown adipose tissue (BAT) and white adipose tissue (WAT

79 The interrelationship between brown adipose tissue (BAT) and white adipose tissue (WAT

80 aining brown adipocyte phenotypes in classic brown adipose tissue (BAT) and white adipose tissue (WAT

81 Although recent studies have shown that brown adipose tissue (BAT) arises from progenitor cells

82 The discovery of brown adipose tissue (BAT) as a key regulator of energy

83 mechanisms of adipogenesis, particularly in brown adipose tissue (BAT) because of its potential util

84 w that subcutaneous transplants of embryonic brown adipose tissue (BAT) can correct T1D in streptozot

85 Brown adipose tissue (BAT) can disperse stored energy as

86 Brown adipose tissue (BAT) combusts high amounts of fatt

87 ose tissue (WAT) stores excess calories, and brown adipose tissue (BAT) consumes fuel for thermogenes

88 Targeting brown adipose tissue (BAT) content or activity has thera

89 Genetic ablation of Slc6a2 in SAMs increases brown adipose tissue (BAT) content, causes browning of w

90 Brown adipose tissue (BAT) could facilitate weight loss

91 Although it has been believed that brown adipose tissue (BAT) depots disappear shortly afte

92 s, it has been shown that humans have active brown adipose tissue (BAT) depots, raising the question

93 Brown adipose tissue (BAT) dissipates chemical energy in

94 Brown adipose tissue (BAT) dissipates energy through Ucp

95 Due to uncoupling, brown adipose tissue (BAT) dissipates energy via heat ge

96 Brown adipose tissue (BAT) dissipates nutritional energy

97 Each cycle, Brown Adipose Tissue (BAT) drives periodic arousal from

98 Promoting brown adipose tissue (BAT) formation and function may re

99 ermogenic networks through the regulation of brown adipose tissue (BAT) function.

100 Brown adipose tissue (BAT) has attracted scientific inte

101 Brown adipose tissue (BAT) has become a focus of researc

102 e tissue (WAT) is a risk factor for disease, brown adipose tissue (BAT) has been suggested to have a

103 Recruitment of brown adipose tissue (BAT) has emerged as a potential to

104 Brown adipose tissue (BAT) has emerged as a therapeutic

105 ed efficient transduction of white (WAT) and brown adipose tissue (BAT) in adult lean and obese diabe

106 The role of brown adipose tissue (BAT) in adult metabolism is poorly

107 The presence of brown adipose tissue (BAT) in adults has become increasi

108 The presence of brown adipose tissue (BAT) in human adults opens attract

109 ly, the existence of significant deposits of brown adipose tissue (BAT) in human adults was confirmed

110 The study of brown adipose tissue (BAT) in human weight regulation ha

111 The recent rediscovery of brown adipose tissue (BAT) in humans made this tissue a

112 subcutaneous depots but not in interscapular brown adipose tissue (BAT) in mice fed a high fat diet (

113 aternal Gnas deletion impaired activation of brown adipose tissue (BAT) in mice, their responses to c

114 However, the role of brown adipose tissue (BAT) in regulating gestational met

115 O) spontaneously develop functioning ectopic brown adipose tissue (BAT) in skeletal muscle, putativel

116 s to assess the volume and function of human brown adipose tissue (BAT) in vivo using MR imaging.

117 In response to cold, brown adipose tissue (BAT) increases its metabolic rate

118 s (rRPa) neurons influences thermogenesis of brown adipose tissue (BAT) independent of ambient temper

119 Brown adipose tissue (BAT) is a highly thermogenic organ

120 Brown adipose tissue (BAT) is a highly vascularized orga

121 Brown adipose tissue (BAT) is a specialized fat tissue t

122 Brown adipose tissue (BAT) is a unique tissue that is ab

123 rily functions as an energy reservoir, while brown adipose tissue (BAT) is activated during cold expo

124 Studies in rodents have shown that brown adipose tissue (BAT) is activated on food intake,

125 Brown adipose tissue (BAT) is an attractive therapeutic

126 Thermogenesis in brown adipose tissue (BAT) is an important component of

127 Brown adipose tissue (BAT) is an important source of the

128 Brown adipose tissue (BAT) is currently considered as a

129 Brown adipose tissue (BAT) is essential for adaptive the

130 Thermogenesis in brown adipose tissue (BAT) is fundamental to energy bala

131 Brown adipose tissue (BAT) is known to function in the d

132 In contrast to white adipose tissue, brown adipose tissue (BAT) is known to play critical rol

133 Spontaneous glucose uptake by brown adipose tissue (BAT) is lower in overweight or obe

134 Brown adipose tissue (BAT) is metabolically active in hu

135 Brown adipose tissue (BAT) is regulated by the sympathet

136 Brown adipose tissue (BAT) is specialized for energy exp

137 Brown adipose tissue (BAT) is specialized to burn lipids

138 Brown adipose tissue (BAT) is specialized to dissipate c

139 Thermogenesis in brown adipose tissue (BAT) is well characterized as bein

140 Detection and quantification of brown adipose tissue (BAT) mass remains a major challeng

141 Brown adipose tissue (BAT) metabolism influences glucose

142 Brown adipose tissue (BAT) mitochondria exhibit high oxi

143 1 (UCP1) expression (fold increase: 3.5) in brown adipose tissue (BAT) of the C57BL/6 control mice.

144 Brown adipose tissue (BAT) plays a key role in thermogen

145 Brown adipose tissue (BAT) plays a unique role in regula

146 Brown adipose tissue (BAT) promotes a lean and healthy p

147 Brown adipose tissue (BAT) provides a means of nonshiver

148 In rodents, brown adipose tissue (BAT) regulates cold- and diet-indu

149 vation state.Current approaches to visualise brown adipose tissue (BAT) rely primarily on markers tha

150 -1R agonist, liraglutide, in mice stimulates brown adipose tissue (BAT) thermogenesis and adipocyte b

151 es sympathetic nervous system stimulation of brown adipose tissue (BAT) thermogenesis and browning of

152 ore body weight and fat, indicating impaired brown adipose tissue (BAT) thermogenesis and/or inabilit

153 beta-Adrenergic receptors (beta-ARs) promote brown adipose tissue (BAT) thermogenesis by mobilizing f

154 to sympathetic premotor neurons that control brown adipose tissue (BAT) thermogenesis, suggesting an

155 PET imaging is routinely used to investigate brown adipose tissue (BAT) thermogenesis, which requires

156 For brown adipose tissue (BAT) to be effective at consuming

157 The capacity for brown adipose tissue (BAT) to protect against obesity an

158 , to determine the contribution of liver and brown adipose tissue (BAT) towards metabolic improvement

159 Brown adipose tissue (BAT) utilizes glucose and free fat

160 Interventions to increase brown adipose tissue (BAT) volume and activation are bei

161 AT) of Mstn(-/-) develops characteristics of brown adipose tissue (BAT) with dramatically increased e

162 Brown adipose tissue (BAT), a specialized fat that dissi

163 comotor activity, increased thermogenesis in brown adipose tissue (BAT), and alterations in fuel subs

164 white adipose tissue (WAT) and interscapular brown adipose tissue (BAT), causing decreased expression

165 Brown adipose tissue (BAT), characterized by the presenc

166 beled lipoprotein-like emulsion particles by brown adipose tissue (BAT), decreased the intracellular

167 l role in determining the metabolic state of brown adipose tissue (BAT), due to its direct roles in t

168 nsumption impairs retinoic acid signaling in brown adipose tissue (BAT), leading to impaired BAT func

169 conducted on inguinal white adipose (IWAT), brown adipose tissue (BAT), liver, and skeletal muscle.

170 As potential activators of brown adipose tissue (BAT), mild cold exposure and sympa

171 comprises 65% of the total GPAT activity in brown adipose tissue (BAT), we characterized BAT functio

172 ed by deep sequencing (ChIP-seq) analyses in brown adipose tissue (BAT), we reveal that PRDM16 bindin

173 reduction in white adipose tissue (WAT) and brown adipose tissue (BAT), whereas mice lacking both IR

174 Brown adipose tissue (BAT)-induced thermogenesis is a pr

175 en stimulated by the recent recognition that brown adipose tissue (BAT)-long known to promote heat pr

176 c imbalance including thermogenic defects in brown adipose tissue (BAT).

177 and activation of adaptive thermogenesis in brown adipose tissue (BAT).

178 te-labeled VLDL-like emulsion particles into brown adipose tissue (BAT).

179 ional regulator of adaptive thermogenesis in brown adipose tissue (BAT).

180 remotor neurons controlling thermogenesis of brown adipose tissue (BAT).

181 r aim was to investigate the role of VEGF in brown adipose tissue (BAT).

182 ism via control of mitochondrial function in brown adipose tissue (BAT).

183 0% in subcutaneous tissue, and 84 and 85% in brown adipose tissue (BAT).

184 and present hypotheses as to the anatomy of brown adipose tissue (BAT).

185 the control of metabolic fuel utilization by brown adipose tissue (BAT).

186 most vessels and shares common features with brown adipose tissue (BAT).

187 esponsible for nonshivering thermogenesis in brown adipose tissue (BAT).

188 d activity of sympathetic fibers innervating brown adipose tissue (BAT).

189 maintaining the integrity of mitochondria in brown adipose tissue (BAT).

190 and UCP1 mRNAs were not induced in liver or brown adipose tissue (BAT).

191 mmortalized preadipocytes derived from mouse brown adipose tissue (BAT).

192 of nonshivering thermogenesis (NST) besides brown adipose tissue (BAT).

193 ng the oxidative and thermogenic activity of brown adipose tissue (BAT).

194 shows a robust and specific PD-L1 signal in brown adipose tissue (BAT).

195 nt of insulin-stimulated glucose uptake into brown adipose tissue (BAT).

196 s that determine the thermogenic capacity of brown adipose tissue before environmental cold are unkno

197 Transplantation of both white and brown adipose tissue-brown especially-into ADicerKO mice

198 eases the expression of thermogenic genes in brown adipose tissue but also induces the expression of

199 ctively binds to the vascular endothelium of brown adipose tissue, but not of intraperitoneal white a

200 ction in glucose metabolism in the white and brown adipose tissue, compared with that in the WT mice.

201 These results indicate that YY1 in brown adipose tissue controls antagonistic gene expressi

202 tein 1 (UCP1) is the established mediator of brown adipose tissue-dependent thermogenesis.

203 rate that this probe can be used to identify brown adipose tissue depots in mice by whole-body near-i

204 UCP1 is also found outside classical brown adipose tissue depots, in adipocytes that are term

205 Owing to limitations of current methods for brown adipose tissue detection, analysing the abundance

206 importance of miRNA processing in white and brown adipose tissue determination and provide a potenti

207 ound unexpectedly that GR is dispensable for brown adipose tissue development in mice.

208 pensable for adipogenesis in culture and for brown adipose tissue development in mice.

209 l, primary adipocyte precursors of white and brown adipose tissue differentiated in vitro produced fe

210 Enhanced WAT thermogenic potential, brown adipose tissue differentiation, and/or insulin sen

211 is implicated in the regulation of white and brown adipose tissue differentiation.

212 Brown adipose tissue dissipates energy as heat, a proces

213 ed lipolysis and neurotransmitter release to brown adipose tissue during cold exposure.

214 eacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic apt

215 sources, such as Huh7 cells, mouse liver and brown adipose tissue, et al.

216 cate that the CPATAERPC peptide localizes to brown adipose tissue even in the absence of sympathetic

217 Brown adipose tissue expends energy in the form of heat

218 e recorded the sympathetic nerve activity to brown adipose tissue; expiratory CO2 and skin, core, and

219 te adipocytes and brite cells, interscapular brown adipose tissue for brown adipocytes, and ear mesen

220 re was observed both in primary cultures and brown adipose tissue from cold-exposed mice.

221 We conclude that brown adipose tissue function in mice does not require t

222 ortant site of thermogenesis especially when brown adipose tissue function is lacking.

223 Here we show 5-HT regulates white and brown adipose tissue function.

224 abnormal fat accumulation in both white and brown adipose tissues, glucose intolerance and insulin r

225 Mechanistically, FL-PGC-1alpha(-/-) brown adipose tissue had an increased capacity to oxidiz

226 ifically in intestinal endocrine L-cells and brown adipose tissue, has made it a promising therapeuti

227 We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) a

228 glucose uptake identifies the interscapular brown adipose tissue (iBAT) as a primary source where gl

229 creased energy expenditure and interscapular brown adipose tissue (iBAT) thermogenesis accompanied by

230 Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an importan

231 genesis in skeletal muscle and interscapular brown adipose tissue (IBAT) was investigated.

232 In interscapular brown adipose tissue (iBAT), cold exposure increased pro

233 sis-regulating proteins in the interscapular brown adipose tissue (IBAT).

234 rs of uncoupling protein-1 (UCP1) in classic brown adipose tissue in female mice, we found that LXRs,

235 analysing the abundance and localization of brown adipose tissue in the body has remained challengin

236 d accumulation and apparent vacuolization of brown adipose tissue in the HD mice.

237 an oxidative tissues (skeletal muscle, heart brown adipose tissue) in the fed state.

238 UCP3, expressed in both skeletal muscle and brown adipose tissue, in thermoregulatory physiology is

239 ession of genes involved in thermogenesis in brown adipose tissue including Dio2, Pgc-1alpha, Pgc-1be

240 pressing SCF systemically or specifically in brown adipose tissue increases thermogenesis and reduces

241 Brown adipose tissue insulin sensitivity and reduced adi

242 Brown adipose tissue is a particularly appealing target

243 Brown adipose tissue is a thermogenic organ that dissipa

244 show that acutely activated thermogenesis in brown adipose tissue is defined by a substantial increas

245 Brown adipose tissue is highly vascularized, facilitatin

246 Recent studies showed that brown adipose tissue is present in adult humans and may

247 Brown adipose tissue is the primary site for thermogenes

248 excess energy in the form of triglycerides, brown adipose tissue is thermogenic, dissipating energy

249 oupling protein 1 (UCP1) is nearly absent in brown adipose tissue lacking HDAC3, and there is also ma

250 ide probe also recognizes the vasculature of brown adipose tissue-like depots of subcutaneous white a

251 Activation of brown adipose tissue manifested as augmented oxygen cons

252 xpression in white adipose tissue along with brown adipose tissue markers PRDM16, CIDEa, and UCP1, co

253 ue, by the up-regulation of angiogenesis and brown adipose tissue markers.

254 Our data indicate that alcohol's effects on brown adipose tissue may be mediated through altered ret

255 UCP1 and UCP3 in brown adipose tissue mediate early and late phases of sy

256 e increased insulin resistance and decreased brown adipose tissue-mediated glucose disposal.

257 omous protection was through preservation of brown adipose tissue metabolism, which was increased in

258 xchange mechanism in its primary function in brown adipose tissue mitochondria.

259 duodenal lipid sensing activates a gut-brain-brown adipose tissue neuraxis to regulate thermogenesis.

260 evated in the white adipose tissue (WAT) and brown adipose tissue of AdSod2 KO mice fed an HFD, and t

261 In contrast, interscapular brown adipose tissue of AF2KO mice accumulated few but l

262 Expression of a human-specific miRNA in the brown adipose tissue of one mouse in vivo can also regul

263 als on high-fat diet increases expression in brown adipose tissue of Pparalpha, Hsl, Cpt1b, and Cd36

264 In addition, during baseline conditions, brown adipose tissue of Ppt1-KO mice had less vacuolizat

265 conventional exon 1a-derived transcripts in brown adipose tissue of wild type and FL-PGC-1alpha(-/-)

266 The brown adipose tissues of cavin-1-null mice exhibited dec

267 dative stress in the thyroid, but not in the brown adipose tissue or liver.

268 Brown adipose tissue oxidizes chemical energy for heat g

269 t mTORC1 activity and enhanced expression of brown adipose tissue PGC1-alpha and UCP1.

270 ondrial fatty acid oxidation capacity of the brown adipose tissue, reduced whole-body energy expendit

271 Salicylate is also able to stimulate brown adipose tissue respiration independent of uncoupli

272 The presence of brown adipose tissue responsible for thermogenic energy

273 al and subcutaneous white adipose tissue and brown adipose tissue, severe growth retardation, and bon

274 IP] followed by deep sequencing) analyses in brown adipose tissue showed that EBF2 binds and regulate

275 Mice with brown adipose tissue-specific genetic ablation of HDAC3

276 ad impaired glucose homeostasis, compromised brown adipose tissue structure, and high insulin and low

277 in tibialis anterior and soleus muscles and brown adipose tissue, suggesting that the transplanted s

278 iture, decreased body temperature, decreased brown adipose tissue temperature, and decreased UCP1 exp

279 Core and brown adipose tissue temperatures, EEG, heart rate, and

280 e tissue; expiratory CO2 and skin, core, and brown adipose tissue temperatures; and shivering EMGs in

281 ain a critical capacity for thermogenesis in brown adipose tissue that can be rapidly engaged upon ex

282 promising approach has been the expansion of brown adipose tissues that express uncoupling protein (U

283 In brown adipose tissue, the absence of Them2 was associate

284 In addition to classical brown adipose tissue, the last few years have seen great

285 n Gpr50(-/-) mice is not due to a deficit in brown adipose tissue, the principal site of nonshivering

286 On one hand, brain UGN induces brown adipose tissue thermogenesis, as well as browning

287 DNP-mediated heat generation substituted for brown adipose tissue thermogenesis.

288 stion that obesity results from variation in brown adipose tissue thermogenesis.

289 3 polyunsaturated fatty acids (PUFA) promote brown adipose tissue thermogenesis.

290 We show that in addition to brown adipose tissue, this peptide probe also recognizes

291 in cardiac muscle, white adipose tissue, and brown adipose tissue through a mechanism that was partia

292 alter the redox status of cysteine thiols in brown adipose tissue to drive increased respiration, and

293 k across the mitochondrial inner membrane of brown adipose tissue to produce heat, and could help com

294 ar fatty acid channeling, Them2 functions in brown adipose tissue to suppress adaptive increases in e

295 a3-adrenoceptors stimulate glucose uptake in brown adipose tissue via a signaling pathway that is com

296 M2 phenotype and expanded the interscapular brown adipose tissue volume.

297 E and activation of thermogenesis in WAT and brown adipose tissue were lost in Fgf21(-/-) mice.

298 ling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupl

299 nic capacity of the interscapular and aortic brown adipose tissues, whereas exercise markedly suppres

300 s in the liver and enhanced thermogenesis in brown adipose tissue which was coincident with a signifi