ライフサイエンスコーパス: bulge

1 of stem cells out of their niche in the hair bulge.

2 t decatenation activity on DNA braids with a bulge.

3 ved in RluF and so RluF cannot stabilize the bulge.

4 trated with a backbone nick and extrahelical bulge.

5 zzled-related protein 1 disappearance in the bulge.

6 stline lies along the ice sheet's peripheral bulge.

7 bluish discoloration of a palpebral surface bulge.

8 cle stem cells residing in the telogen basal bulge.

9 he midvein, and appearance of the primordium bulge.

10 rs, three double-chain-reversal loops, and a bulge.

11 ons in different compartments, including the bulge.

12 ighly conserved stem-loop I and a downstream bulge.

13 the gastrointestinal tract and hair follicle bulge.

14 smatch and positively supercoiled DNA with a bulge.

15 gnificant at labels in the loop and near the bulge.

16 ation of tertiary interactions in the A-rich bulge.

17 iligo bulge compared with untreated vitiligo bulge.

18 n of the anterior urethra ending in a smooth bulge.

19 in/Wnt pathway activity in the dental lamina bulge.

20 instead dispersing to form galactic disks or bulges.

21 nd afterwards migrate inwards to form galaxy bulges.

22 ified at different positions with 1- to 5-bp bulges.

23 nts are interspersed with internal loops and bulges.

24 braids of intact dsDNA and nicked dsDNA with bulges.

25 g the star-formation histories of the galaxy bulges.

26 nts are interspersed with internal loops and bulges.

27 he formation dynamics and stability of these bulges.

28 to mitigate the risk of port-site hernia and bulging.

29 of interest were SSI, hernia recurrence, and bulging.

30 Previously, deletion of a three-base bulge (18-CCA-20) in the pRNA A-helix was shown to aboli

31 s 34.1%; P < .01) but more clinical cases of bulging (21.5% vs 1.3%; P < .01) and port-site hernia (2

32 By contrast, single-base bulges 6'U7' and 6'A7' on the target strand are looped-o

33 Our studies establish that single-base bulges 7T8, 5A6 and 4A5 on the guide strand are stacked-

34 delayed viscous adjustment of the rotational bulge acts to stabilize the rotation axis, geodynamic mo

35 The bulge actually involves five nucleotides (17-UCCA-20 and

36 sts of a 2'-5' phosphodiester bond between a bulged adenosine and the 5' end of the intron.

37 terior muscle herniated and produced a focal bulge along the anterior aspect of the leg.

38 The associated sequence pattern, a 3-nt bulge and G-A, A-G base-pairs, generates an angle of app

39 Bank (PDB) files were searched for internal, bulge and hairpin loops, and each loop's structural info

40 econdary structural motifs such as internal, bulge and hairpin loops.

41 s by a thymine, which forms a single-residue bulge and is projected out of the G-tetrad core.

42 We show the bulge and nexus are necessary for DNA cleavage and demon

43 f-target sites, each harboring a single-base bulge and one to three mismatches to the guide strand.

44 ramolecular G-quadruplex containing a single bulge and present evidence for extensive occurrence of b

45 n 15 negative (K15-) stem cells in the upper bulge and remained associated with the K15- upper bulge

46 hich enters the TAR major groove between the bulge and the central loop.

47 o conserved motifs, the Adenine-guanine (AG) bulge and the distal loop.

48 genic factor Egfl6 was expressed by the K15- bulge and was localized adjacent to the vascular annulus

49 xponential method displaying low-temperature bulges and domain artifacts that can lead to incorrect g

50 rease of label-retaining cells (LRCs) in the bulges and enhanced CFE in vitro.

51 also analyzed the most frequently occurring bulges and internal loops for each RNA class and found t

52 cal disorder in noncanonical residues within bulges and loops and resulted in 0.3-4-fold reduction in

53 hal: cells become filamentous, form envelope bulges and lyse, resembling treatment with beta-lactam a

54 Spontaneous formation of ssDNA bulges and their diffusive motion along SSB surface was

55 IC, and leads to K(+)-mediated mitochondrial bulging and depolarization.

56 d with fewer SSIs but more clinical cases of bulging and with the risk of developing a port-site hern

57 rs, a folded 2X2 (GU/UA) internal loop, a UU bulge, and a flexible AGUGA apical loop.

58 The ion exchange reactions affected bump, bulge, and crack formation on the biotite basal plane, a

59 he 2-helix junction structure contains a GGA bulge, and purine-rich bulges are common motifs in RNA s

60 s than RuvC, cleaving a variety of branched, bulged, and flap-containing substrates.

61 evealed the formation of helical turns, beta-bulges, and alpha-turns in cyclic peptides cross-linked

62 though K15-positive stem cells in the mutant bulge are comparable in number to the control, their abi

63 lial stem cells (EpSCs) in the hair follicle bulge are required for hair follicle growth and cycling.

64 t Tcf3-expressing cells in the hair follicle bulge are self-renewing stem cells with multilineage pot

65 ucture contains a GGA bulge, and purine-rich bulges are common motifs in RNA secondary structure.

66 lls-epithelial cells located in the follicle bulge-are activated by periodic beta-catenin activity, w

67 ld also open the possibilities of exploiting bulges as recognition elements for interactions between

68 er than being halo stars passing through the bulge, as expected for stars formed at redshifts greater

69 condary structure as in the ribosome, with a bulge at A2602, but with 5-FU2605 flipped into the activ

70 form by attachment to a surface via a large bulge at the base of the flagellum, which is then remode

71 a stable alignment for the looped-out 6'N7' bulge base, which stacks on the unpaired first base of t

72 e demonstrate that asymmetrically positioned bulged bases in the miRNA:miRNA* duplex, regardless of m

73 s of different lengths and the presence of a bulge between the G-quartets are structural elements tha

74 This progresses to gagging, gasping, eye bulging, bradycardia, cyanosis, and vomiting.

75 Also, bulge Brg1 is activated by skin injury to facilitate ear

76 ernia recurrences and more clinical cases of bulging (bulging not associated with recurrence or serom

77 HR is associated with more clinical cases of bulging but fewer SSIs.

78 m ( approximately 10 mum thick) causes it to bulge by tens of microns.

79 Our results show that bulges can be formed in many different situations within

80 22-nt nta-miR6019 depended on an asymmetric bulge caused by mismatch in the nta-miR6019 precursor.

81 the CD200+/K15+ bulge compared to other non-bulge CD34+ and K15+ progenitor compartments and found t

82 eviously described integrin alpha6(+)CD34(+) bulge cell population, and 28.9+/-8.6% were label-retain

83 r, Brg1 is indispensable for maintaining the bulge cell reservoir.

84 of this model reproduce straight, bent, and bulged cell shapes, and we discuss how this model is con

85 Without Brg1, bulge cells are depleted over time, partly through the e

86 Ablating Wnt signaling in the bulge cells causes them to lose their stem cell potency

87 Bulge cells express secreted Wnt inhibitors, including D

88 e into the cytokeratin 6-positive (K6) inner bulge cells in telogen, which regulate the quiescence of

89 h, whereas paracrine Wnt inhibition of inner bulge cells reinforces differentiation.

90 Bulge cells show increased levels of epigenetic repressi

91 dgehog (Shh) signals Gli to activate Brg1 in bulge cells to begin hair regeneration, whereas Brg1 rec

92 eling machinery, is dynamically expressed in bulge cells to control tissue regeneration and repair.

93 Hair follicle stem cells (bulge cells) are essential for hair regeneration and ear

94 gical abnormalities, including shortened and bulging cells, suggesting a cell wall defect.

95 al" i.e. their seed region comprises G:U and bulge combinations.

96 ive cell cycle inactivity of the CD200+/K15+ bulge compared to other non-bulge CD34+ and K15+ progeni

97 nocytes captured from NBUVB-treated vitiligo bulge compared with untreated vitiligo bulge.

98 insertions ('DNA bulge') or deletions ('RNA bulge') compared to the RNA guide strand, and Cas9 nicka

99 ite induces an intermediate state in which a bulge conformation at Ser-382 in a transmembrane helix i

100 in which the peptides adopted distinct super-bulged conformations.

101 Midcell bulges contained bands or foci of FtsA-GFP and FtsZ-GFP

102 The stabilized bulge delays lysis and allows recovery upon drug removal

103 We identify two bulge-depleted regions on the miRNA stem, located approx

104 The height of the bulge deposited directly next to the channel was reduced

105 Cav1.2 regulates production of the bulge-derived BMP inhibitor follistatin-like1 (Fstl1), d

106 mations, providing a route for extending our bulge-directed framework to internal loop motifs and imp

107 Reducing the bulge does not interfere with miR398-mediated regulation

108 The distance distributions for the AAA bulge duplex (3A-DNA) with six different Au-Au pairs pro

109 Dkk3 continues to be localized to the inner bulge during the hair cycle growth phase.

110 vo expansion of hEPI-NCSC isolated from hair bulge explants, manipulating the WNT, sonic hedgehog and

111 s, characterized by a small but critical 'A' bulge flanked by two G:C base pairs embedded in a comple

112 alization within the bulge to the entire sub-bulge follicle and cyst, and ectopic expression of kerat

113 standard k-turn comprises a three-nucleotide bulge followed by G.A and A.G pairs.

114 53 infants were reported to have a bulging fontanelle; 32 (0.3%) in the vitamin A group and

115 ant roothairless 6 (rth6) are arrested after bulge formation during the transition to tip growth and

116 description to include the possibilities of bulge formation should allow the identification of more

117 s proceeded through four stages: elongation, bulge formation, bulge stagnation, and lysis.

118 Our results show that the bulge-formation dynamics are determined by how the cell

119 ce the feature size of microchannels and the bulges formed at the rim of the channel during CO2 laser

120 hod was further extended to assigning a 6 nt bulge from a 61 nt viral RNA element justifying its use

121 rmation of warty lesions, with cell clusters bulging from the epidermal layer, and some cells expandi

122 loss of aPKClambda altered the fate of lower bulge/hair germ stem cells.

123 metal, and a new DNAzyme (named Ce13) with a bulged hairpin structure was isolated and characterized.

124 The formation of bulges has also been observed in two different G-quadrup

125 o have thicker sclera (P = .067) and greater bulge height (P = .079).

126 The CCT was positively correlated to macular bulge height but not to BCVA.

127 eyes and significantly increased for macular bulge height greater than 350 mum (P = 0.0047).

128 The mean macular bulge height was 407.7 +/- 215.1 mum (120-1130) and was

129 inal, choroidal, and scleral thicknesses and bulge height were measured on SD OCT.

130 Choroidal thickness, scleral thickness, and bulge height were positively correlated (P < .01).

131 However, once activated, bulge HF-SCs begin to differentiate into epidermal cells

132 GT) embryonic cilia exhibited shortening and bulging, highly similar to the characterised retrograde

133 Importantly, IRES mutations that delete the bulge impair viral translation and completely inhibit re

134 t to the outer domain into the emerging hair bulge in Arabidopsis (Arabidopsis thaliana).

135 The same process also generates a bulge in the non-target DNA strand, enabling its handove

136 with disease progression that might cause a bulge in the prostate gland.

137 A hydrogen-bonding network stabilizes the bulge in the RluB-RNA but is not conserved in RluF and s

138 off-target analysis related to DNA and sgRNA bulges in addition to base mismatches, and suggest speci

139 present evidence for extensive occurrence of bulges in different G-quadruplex contexts.

140 port a model in which the internal loops and bulges in HDV RNA contribute flexibility to the quasi-do

141 es used for paired nicking can also tolerate bulges in one of the guide strands.

142 ile hosting fully grown and already quenched bulges in their cores.

143 We further reveal the prevalence of axon bulging in the brain cortex in vivo after mild compressi

144 As the new hair emerges, the entire old bulge, including its reserve HFSCs and SC-inhibitory inn

145 extremely metal-poor stars in the Milky Way bulge, including one star with an iron abundance about 1

146 ity and bulge-length amplitude dependence of bulge induced inter-helical bends.

147 es 'closed' loops of various types (hairpin, bulge, internal, and junction loops) and pseudoknots of

148 The bulge introduces a 33-35 degrees bend in the helical axi

149 mble reveals local motions in and around the bulge involving changes in stacking and hydrogen-bonding

150 r, these findings demonstrate that the upper bulge is associated with a perivascular niche during the

151 ur data suggest that the non-template strand bulge is extruded into solvent in complexes containing a

152 In addition, a thymine bulge is found between G8 and G9.

153 ses HFSCs for the next hair cycle, the older bulge is left unanchored.

154 Finally, we show that when the old bulge is lost with each hair cycle, overall levels of SC

155 m cells leading to their accumulation in the bulges is indicated by a strongly reduced response to mo

156 e further demonstrate that the occurrence of bulges is not a rare phenomenon and should be accounted

157 in violence tend to follow population "youth bulges." Large numbers of adolescents in equatorial regi

158 road conformational ensemble with increasing bulge length.

159 e experimentally observed directionality and bulge-length amplitude dependence of bulge induced inter

160 In particular, bulge loop initiation, multibranch loop initiation, AU/G

161 We identified a highly asymmetric bulge loop motif that resembles the rope sling.

162 evidence for interaction of the sub-terminal bulge loop of SL9266 and sequences around nucleotide 911

163 Specifically, we show that bulge loop structures within an extended repeat domain c

164 that uranyl binds between T23 and C25 in the bulge loop, G11 and T12 in the stem loop of the enzyme s

165 ds the 5'-terminal region of HIV mRNA's stem-bulge-loop structure, the transactivation-responsive (TA

166 the mean first-passage time associated with bulge looping out increases slowly upon increasing press

167 such as non-canonical, primarily U-G pairs, bulge loops and three-way junctions.

168 onstrate that such "rollameric" migration of bulge loops within repeat sequences can invade and disru

169 st that autocrine Wnt signaling in the outer bulge maintains stem cell potency throughout hair cycle

170 ll-wall synthesis and induce lysis through a bulge-mediated mechanism; however, little is known about

171 ranscriptome RNA sequencing of hair follicle bulge melanocyte precursors and compared their gene sign

172 e potential key players in the activation of bulge melanocyte precursors during vitiligo repigmentati

173 of TNC, GJB6, and THBS1 in the hair follicle bulge melanocytes and of TYR in the epidermal melanocyte

174 HIV-1 TAR RNA is a two-helix bulge motif that plays a critical role in HIV viral repl

175 is of miR-122-dependent binding revealed a G-bulged motif in addition to canonical motifs.

176 tain histone tail conformations promoted DNA bulging near its entry/exit sites, resulting in the form

177 urrences and more clinical cases of bulging (bulging not associated with recurrence or seroma).

178 s may have a modified 8/4 structure with one bulge nucleotide.

179 contains several unique features including a bulged nucleotide and the first crystal structure observ

180 adruplexes in the asymmetric unit, while the bulged nucleotide mediates crystal contacts.

181 ected features that include three individual bulge nucleotides and a C(+)*G-C triple adjacent to a st

182 stabilizes extrahelical conformations of the bulge nucleotides, thereby promoting coaxial stacking of

183 oncanonical base-pairing registers involving bulged nucleotides on either the 5'ss or U1 RNA strand,

184 ons between residues on the C-helix and beta-bulge of cytP450 and residues at the end of helix alpha4

185 that vascular annuli formed around the upper bulge of de novo-reconstituted hair follicles before the

186 melanocyte stem cells (McSCs) located in the bulge of hair follicles can regenerate mature melanocyte

187 est stem cells [hEPI-NCSC(s)] present in the bulge of hair follicles.

188 e in its 5'-untranslated region (UTR) with a bulge of six nucleotides opposite to the 5' region of th

189 p putative stem cells to the distal enlarged bulge of the dental lamina that contains quiescent odont

190 thy, but specifically confined in the inward bulge of the staphyloma and secondary to excessive scler

191 OCT (P < .001) were noted inside the inward bulge of the staphyloma between eyes with and without se

192 The old, red stars that constitute the bulges of galaxies, and the massive black holes at their

193 n increasing bend angle of DNA duplexes with bulges of one, three, and five adenosine residues, consi

194 n which clumps survive feedback and grow the bulges of present-day galaxies.

195 Stem cells located at the bulges of the hair follicles are responsible for hair cy

196 rs the asynchronous fluctuations and outward bulging of the cell edge, and the dependence of the edge

197 Mitral valve prolapse is defined as abnormal bulging of the mitral valve leaflets into the left atriu

198 ally be found today in the central regions ('bulges') of galaxies, because they formed in the largest

199 Once locked, Charon raises a permanent tidal bulge on Pluto, which greatly enhances the gravity signa

200 the substorms and the formation of the three bulges on the plasmasphere.

201 e, the size, the position, and the number of bulges on the structure and stability of G-quadruplexes.

202 ays that independently monitor the impact of bulges on TtAgo-mediated cleavage reaction.

203 plays an independent role in stabilizing the bulge once it is formed.

204 nd frequent off-target sites with a one-base bulge or up to 13 mismatches between the single guide RN

205 ed interactions are noncanonical, containing bulged or mismatched nucleotides.

206 when DNA sequences contain insertions ('DNA bulge') or deletions ('RNA bulge') compared to the RNA g

207 he inner Galaxy, associated with the stellar bulge, or the thick disk.

208 ilure requiring retreatment or self-reported bulge; or anatomic POP failure requiring retreatment or

209 that longer peptides can also bind by either bulging out of the groove in the middle of the peptide o

210 The amnioserosa tissue bulges outward during the early-to-mid stages of closure

211 ct binding mechanism, namely "bypassing" the bulged peptide and making extensive contacts with the ex

212 ments (8-10 amino acids in length), longer, "bulged" peptides are often be presented by MHC-I.

213 ises a range of TCRs that can interact with "bulged" pHLA-I epitopes using unpredictable strategies,

214 peptide-centricity of TCR ligation toward a bulged pMHC-I complex.

215 nderscoring the interaction between TCRs and bulged pMHC-I complexes are unclear.

216 Such bulged pMHC-I complexes represent challenges for T-cell

217 go) ternary complexes containing single-base bulges positioned either within the seed segment of the

218 king interactions in a conserved 5'-AUAGC-3' bulge preorganize the adjacent helices at nearly orthogo

219 the A-form helix and the finite length of a bulge provide a physical basis for the experimentally ob

220 cked in place because of the permanent tidal bulge raised by Charon.

221 e normal cylindrical shape to a branched and bulging, ramified shape, which we call 'coli-flower'.

222 e emission of annihilation gamma-rays in the bulge region of our Galaxy.

223 ion in the tissue and, interestingly, in the bulge region of the HF, a major reservoir of epidermal s

224 escent stem cells (SC) are maintained in the bulge region, and hair bulbs at the base contain rapidly

225 However, Amt-Nea,Azq binds at the bulged region in a similar way than Amt-NeaG4.

226 etantrone intercalates in the characteristic bulged region.

227 etate-induced proliferation and migration of bulge-region stem cells in vivo.

228 ximately 5% of human 5'ss) in 6577 genes use bulge registers.

229 er the 5'ss or U1 RNA strand, which we term "bulge registers." By combining experimental evidence wit

230 ing a 5-mer RNA, whereas the template strand bulge remains within the template strand tunnel, exertin

231 ed Ki-67 expression and EdU incorporation in bulge resident K15+ cells, but not in supra/proximal bul

232 ional analysis showed these newly identified bulge residues are important for DNA packaging.

233 a global change in strand register, in which bulge residues pair up with residues in the upper stem,

234 The retention of at least two bulged residues in this region was essential for pRNA bi

235 s, one containing a gapped RNA and another a bulged RNA, reveal that conformational changes of an RNA

236 ived progenitor cells, rather than quiescent bulge SCs, for anagen HF repair can be a potential appro

237 (+) basal hair bulb progenitors, rather than bulge SCs, were quickly activated to replenish matrix ce

238 Mutating the bulge sequence to 5'-ACCCC-3' ablates base stacking in t

239 ble from changes in ionic conditions and the bulge sequence, effects that can be understood in terms

240 with conformational changes localized to the bulge site, thereby having minimal impact on the cleavag

241 gh four stages: elongation, bulge formation, bulge stagnation, and lysis.

242 We confirm that most of the metal-poor bulge stars are on tight orbits around the Galactic Cent

243 nded to the loss of markers of the quiescent bulge stem cell population, and an increase in epidermal

244 ce lacking TRs do not have a decrease of the bulge stem cell population.

245 Keratinocytes of the bulge stem cells (SCs) niche of Ctip2(ep-/-) mice prolif

246 by a gradual loss of quiescent hair follicle bulge stem cells and a temporary increase in proliferati

247 a reduction in the number or function of the bulge stem cells could be responsible for this phenotype

248 and intercellular signaling (Shh) to control bulge stem cells during tissue regeneration.

249 Fbeta Smad signalling, which is localized to bulge stem cells in both normal human and murine skin.

250 factor expressed primarily in hair follicle bulge stem cells in mice.

251 Altered function of the bulge stem cells is associated with aberrant activation

252 ifferentiation, and maintenance of epidermal bulge stem cells likely through its role in balancing sy

253 hout the hair cycle quiescent phase in outer bulge stem cells that produce their own Wnt signals.

254 Hair follicle bulge stem cells were completely absent, despite the con

255 expansion and later decline of hair follicle bulge stem cells, accompanied by an enrichment of commit

256 h denervation altered the phenotype of upper bulge stem cells, the vascular annulus persisted in surg

257 ne network governing the homeostasis of hair bulge stem cells, we developed a Keratin 15-driven genet

258 ls but results in depletion of hair follicle bulge stem cells.

259 h simultaneously remodels the structure of a bulge, stem, and apical loop.

260 In bulge-stem-loop constructs of HIV-1 transactivation resp

261 t tRNA-derived sequences with predicted stem-bulge-stem-loop structures are sufficient to mediate mRN

262 rying oligonucleotide duplexes mimicking the bulged structure of endogenous pre-miRNA (but not siRNA-

263 y uncharacterized noncanonical long loop and bulged structures.

264 treated cells formed midcell circumferential bulges, suggesting that interrupted PG synthesis destabi

265 anatomic success), (2) no bothersome vaginal bulge symptoms, and (3) no re-treatment for prolapse at

266 tral nucleotides of the DNA form a prominent bulge that contacts the SH3-like domain, while the nucle

267 becomes localized to the Wnt-inactive inner bulge that contains differentiated cells.

268 is consistent with a frozen tidal-rotational bulge that formed later, at a semi-major axis of about 3

269 ugh FOXC1-deficient HFs can still form a new bulge that houses HFSCs for the next hair cycle, the old

270 by melanocyte precursors from hair follicle bulge that proliferate, migrate, and differentiate into

271 The DNA bulges that form within the transcription bubble in RPIT

272 ere, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of human sca

273 In contrast to stem cells in the bulge, the identities of the progenitors and the mechani

274 and remained associated with the K15- upper bulge throughout the hair cycle.

275 -positive cells from localization within the bulge to the entire sub-bulge follicle and cyst, and ect

276 Deletion of the beta-bulge trigger-loop results in both a switch in the prefe

277 pe I' beta-turn and a misfolded state with a bulged turn, providing evidence for distinct conformatio

278 assign the population of type-II beta turns, bulged turns, and irregular beta turns for each peptide.

279 sical titrations reveal that the 5'-AUAGC-3' bulge undergoes a conformational change to assemble a fu

280 The Milky Way bulge underwent a rapid chemical enrichment during the f

281 ns, we substituted the universally conserved bulged uridine (U51) in the P4 helix of circularly permu

282 RNA with metal ions, demonstrating that the bulged uridine coordinates at least one catalytic metal

283 inferred midnight transit times of the three bulges, using the rotation rate of the Earth, coincide w

284 CA5, SB27, and SB47, complexed with a "super-bulged" viral peptide (LPEPLPQGQLTAY) restricted by HLA-

285 Investigation of the architectural (i.e. bulge vs. contiguous pairs) and sequence (Watson-Crick v

286 vision and was more common when the macular bulge was highly elevated.

287 Base stacking in the bulge was investigated using the fluorescent purine anal

288 The height of the macular bulge was measured, and the choroidal thickness was mapp

289 A foveal bulge was not present in 67% of patients.

290 Stem cells in the hair follicle bulge were largely protected from apoptosis upon p14(ARF

291 activity of RNAs in which internal loops and bulges were mutated and of synthetically designed RNAs d

292 t in the untreated and treated hair follicle bulge, whereas a possible secondary melanocyte germ comp

293 in2 expression remains confined to the outer bulge, whereas Dkk3 continues to be localized to the inn

294 observing period, the plasmasphere had three bulges which were located at different geomagnetic longi

295 n yielded a substrate with an off-center DNA bulge, which after cleavage released a labeled short sta

296 s the tRNA anticodon, and the antiterminator bulge, which base pairs with the tRNA acceptor end.

297 The hair follicle bulge, which contains melanocyte stem cells, was also re

298 bsence of symptoms associated with a vaginal bulge, which correlates best with a patient's perception

299 SMAD3 binds RNA with large internal loops or bulges with high apparent affinity.

300 general understanding about the formation of bulges within G-quadruplexes, we systematically investig