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1 ensional spectroscopy have thus far remained bulky.
2 abeling, face structural constrains, and are bulky.
6 enzyme active site can be expanded to employ bulky 2KG analogues that do not sensitize wild type deme
8 tment; presence of abdominal metastases; and bulky abdominal metastases (more than 10 lesions larger
9 nterquartile range, 36-78.7 months); all had bulky abdominal metastases except one patient who presen
15 he effect of transcription factor binding on bulky adducts formation varies, depending on the specifi
19 emoglobin <10 g/L, platelets <100 x 10(9)/L, bulky adenopathy and/or organomegaly, symptomatic hyperv
20 inantly to anti (17a and 17b) by introducing bulky alkyl groups (e.g., propyl groups) onto the hydrox
23 substituted carbazol-9-yl and the extremely bulky amides [N(R)(Ar')](-) (Ar' = 2,6-{C(H)Ph2}-4-R'-C6
24 hindered urea bond chemistry (reaction of a bulky amine with an isocyanate), incorporation of the ca
25 nds (HUBs) that can reversibly dissociate to bulky amines and isocyanates, the latter of which can be
27 rmore, substitution of His-36 with a similar bulky amino acid, phenylalanine, maintained the receptor
28 can be drastically slowed down by employing bulky ancillary ligands at the gold catalyst; the cataly
29 r in-vivo or in-vitro studies are expensive, bulky and consume substantial power, confining the techn
31 ases have their strong absorption lines, are bulky and expensive and rely on nonlinear frequency down
35 Surprisingly, in all three structures, the bulky and hydrophobic BP pyrenyl residue is entirely sol
36 quiring large magnetic fields that make them bulky and lossy, there has been significant interest in
38 f the L1 ligand in a C-N-C mode in which the bulky and rigid o-carborane fragment is cyclometalated v
41 ploy commercial perfusion equipment which is bulky and--being designed almost exclusively for light m
44 nd between residues Trp28 and Asp58, but the bulky aromatic side chain of Trp28 is important for acti
45 n of the peptide chain on either side of the bulky aromatic side chain, which can potentially act as
47 t, replacing tyrosine 169 with either of the bulky, aromatic residues, phenylalanine or tryptophan, s
48 tutions at R1 but has a clear preference for bulky aryl amide groups at R2, while methylation at R3 i
50 ong alkyl or oligoethylene glycol spacers or bulky barriers in-between the binding stations, and a si
51 thod for capturing oligonucleotides carrying bulky base adducts, including UV-induced cyclobutane pyr
53 erification on zeolite beta is suppressed by bulky base molecules (2,4,6-collidine and 2,6-ditertiary
54 here that cobalt(II) catalysts supported by bulky beta-diketiminate ligands have the appropriate kin
55 ble pi-R-allylpalladium complexes containing bulky biaryl- and bipyrazolylphosphines with extremely b
56 nced reactivity of copper catalysts based on bulky bidentate phosphine ligands originates from the at
59 exanone by lithium aluminum hydride and by a bulky borohydride reagent were investigated computationa
60 his is due to steric effects imparted by the bulky Bu(t) groups that distort the geometry of the comp
61 triazole conjugates having a hydrophobic and bulky C(5) arm showed higher selectivity toward cancer c
62 compounds, we suggest that lipophilic N6 and bulky C2 substituents can promote stable and long-lived
66 re, maintenance of ER/Golgi architecture and bulky cargo transport are the primary functions for Tang
67 go1-depleted cells persist in the absence of bulky cargo, showing that they are due to a secretion-in
68 onal COPII-coated vesicles, so how are these bulky cargoes exported from the endoplasmic reticulum (E
69 l a general role for TANGO1 in the export of bulky cargoes from the ER and identify a specific requir
70 t growth of transport carriers for exporting bulky cargoes requires addition of membranes and not sim
71 solid state NMR, and DFT data argue that the bulky catalyst benzyl groups expand the "cationic" metal
76 els of screw-sense preference are induced by bulky chiral tertiary amino acids carrying amide protect
80 with extensive manual labor, are tethered to bulky control systems, and have cumbersome user interfac
82 of excised neurons probed with cryogenic or bulky detectors that do not provide single-neuron spatia
84 reveals a "chiral crown" conformation with a bulky dicyclohexylphenyl acetate ligand and three N-naph
85 establishing the fluid gate potential with a bulky, difficult to microfabricate reference electrode t
87 ced (stage III or IV) disease, with stage II bulky disease considered as limited or advanced disease
89 , event-free survival (EFS) of patients with bulky disease was inferior without additive RT (hazard r
90 re, international prognostic score >/= 4 and bulky disease were no longer prognostic in patients who
91 794 eligible patients, 264 had stage I or II bulky disease, 135 received ABVD, and 129 received Stanf
92 nosis (including the presence of B symptoms, bulky disease, advanced stage, or extranodal disease), r
94 elated with younger age, higher frequency of bulky disease, lower hemoglobin levels, higher leukocyte
95 endamustine-rituximab as primary therapy for bulky disease, profound hematologic compromise, or const
100 cetylaminofluorene (NA-AAF), which generates bulky DNA adducts that block RNA polymerase movement.
102 e DNA to a better extent compared with other bulky DNA damages, and this property will make it diffic
107 topologically complex NLSs that lie next to bulky domains or are masked by quaternary structures.Imp
108 ing hydrogen evolution, the highly basic and bulky (dppv)Ni(mu-pdt)Fe(CO)(dppv) ([1](0); dppv = cis-C
109 To this aim, quantitative replacement of the bulky electrically insulating ligands at the QD surface
111 cope of the catalysis encompasses sterically bulky enynamines including terpene natural products.
112 fied the flexible loop region connecting the bulky enzymatically active head and the four-helix bundl
113 ten require trained personnel, expensive and bulky equipment, and have large power requirements.
118 s, for which the ultrafine resolution of the bulky, expensive, and high-maintenance NMR spectrometers
119 ngs, sophisticated time-lapse microscopy, or bulky/expensive chemo-stat instrumentation for dynamic m
120 ering approaches require the use of hard and bulky external switches or valves, incompatible with bot
127 uffer from expensive specialized substrates, bulky fusion tags, low yields, and extra purification st
128 was also designed to encapsulate and release bulky globular proteins, such as mCherry, in a light-dep
131 emodel their glycocalyces, by overexpressing bulky glycoproteins like mucins, exhibit a higher predis
133 le enantiomers of the rotaxane result from a bulky group in the middle of the thread preventing a ben
134 steric arguments emphasizing the role of the bulky group of the catalyst that prevents the approach o
135 e amide nitrogen atom to be substituted with bulky groups, we developed quinazoline-based imaging too
136 nvolved-field RT [36 Gy] to sites of initial bulky [>/= 7.5 cm] disease and extralymphatic involvemen
138 coordination mode is exploited by sterically bulky HDAC6-selective phenylhydroxamate inhibitors.
139 op region acts as a "hinge" around which the bulky head of HN swings to-and-fro to facilitate timely
140 rting motifs, YXXPhi (where Phi represents a bulky hydrophobic amino acid) and LL, that are important
141 tifs, a C-terminal motif containing a mix of bulky hydrophobic and positively charged residues, and a
143 chain (the "pEF head") confers a pronounced bulky hydrophobic nature to the AbetapE3 N terminus that
145 eristic of negative curvature lipids, with a bulky hydrophobic region and a relatively small hydrophi
146 of enantiospecificity and the tolerance for bulky/hydrophobic functions as substituents of a canonic
151 ibrillation technologies has progressed from bulky internal defibrillators paddles applied directly t
153 d Lewis pairs (FLPs) by the hydroboration of bulky isocyanates (iPr2) ArNCO ((iPr2) Ar=2,6-iPr2 C6 H3
157 te the 10-mer peptide DPC revealed that this bulky lesion can be accommodated in the polymerase activ
158 ses the ability of Pol II to accommodate the bulky lesion, and addition of transacting factor TFIIF f
160 (Core7) without the CAK module and show that bulky lesions in DNA inhibit the ATPase and helicase act
161 -flipping mechanism that enables excision of bulky lesions more commonly associated with nucleotide e
164 rogen is not the result of coordination to a bulky Lewis acid prior to C-H activation, but the combin
165 ted Lewis pairs': unquenched combinations of bulky Lewis acids and bases whose dual reactivity can be
166 f steric perturbation, although catalysis by bulky Lewis acids increased the proportion of exo-ester
168 c conditions with Pd2(dba)3 (2.5 mol%) and a bulky ligand (JackiePhos, 10 mol%) controlling the beta-
170 sis indicates that the presence of rigid and bulky ligands is the key to the successful crystal forma
171 Ph)60 with HS-(CH2)n-Ph (where n = 1 and 2), bulky ligands like adamantanethiol and cyclohexanethiol.
174 ipyrazolylphosphine ligands, while extremely bulky ligands were accommodated by a cationic scaffold.
177 heless, fibrils with parallel molecules show bulky loops formed by residues 1 to 7 located on the sam
178 (CLL) with adverse characteristics including bulky lymphadenopathy (80%), extensive prior therapy (me
179 uthors analyzed 61 untreated patients with a bulky lymphoma (at least one tumor mass >/=7 cm in diame
180 tibody (mAb) (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models.
188 hly toxic interstrand cross-links (ICLs) and bulky minor groove adducts normally recognized by Fancon
190 port, CymA mediates the passive diffusion of bulky molecules via an elegant transport mechanism in wh
191 "OM size-exclusion limit," and the uptake of bulky molecules with molecular masses of more than appro
193 process, and when combined with the use of a bulky monodentate phosphine ligand, interrupts the catal
194 In the presence of palladium catalysts with bulky monodentate phosphines (SPhos and Cy-CarPhos) and
200 actors, including patient age, contralateral/bulky neck disease, increasing number of positive lymph
203 ic effect of pHIFU and thermal parameters in bulky normal muscle tissues based on a rabbit model and
205 on of the 5-methyl-3-arylthiohydantoin ring, bulky o-aryl substituents at N3 were found to suppress t
206 -electronic approach eliminates the need for bulky optical components and cameras for monitoring.
208 us light but reduce imaging speed or rely on bulky optical elements that prevent in vivo imaging.
210 any potentially useful substrates, including bulky or electron-deficient indoles, are poorly accepted
211 he pKa values calculated for acids that have bulky or large bite angle chelating ligands deviate the
214 ly steric because propofol analogs with less bulky ortho substituents activated both wild-type and mu
217 ause its sites are external and another one, bulky PEI, capable of low CO2 adsorption due to the inte
219 combination therapy inhibited the growth of bulky peritoneal tumors and reduced systemic drug toxici
220 ated with tert-butyl hydroperoxide (TBHP), a bulky peroxide, to oxidise only solvent accessible Met r
221 dynamics simulation data suggested that the bulky Phe acts as a pawl that stabilizes the downward ra
223 years, the substrate scope has evolved from bulky polar species to include a wide range of unsaturat
224 results from steric interactions between the bulky porphyrin ligand and the intermediate substrate ra
226 constitute a miniaturized counterpart to the bulky prism configuration and offer remote operation in
228 tionally been achieved by placing sterically bulky "protecting groups" at the termini, which shield t
230 The Mg(2+)-bound structure shows that the bulky Pt-GG adduct is accommodated in the polbeta active
234 vely charged loop near the NrdI flavin and a bulky residue (Thr) at a constriction in the oxidant cha
235 without NSAIDs indicated that placement of a bulky residue at position 89 caused a closure of a gap a
237 lexes, extended the sampling times for large bulky residues, incorporated the modeling of glycans on
240 native MATs), the gained activity toward the bulky SAAMs stems from their ability to maintain the des
241 in the form of an RNA:DNA hybrid segment or bulky secondary structures, indicating a dsRNA scanning
246 We found that substituting Gln-1291 with bulky side-chain amino acids abolished the effects of Ap
247 nner helix suggest an important role for its bulky sidechain in the allosteric mechanism; we show tha
249 Surprisingly, calculations predict that the bulky silylethynyl substituents of TMS-PT and TMS-BT hav
250 ully aligned focused light, which comes with bulky size and alignment issues that hinder the realizat
252 velengths constrain current spectrometers to bulky sizes, our nano-3D printed prototypes demonstrate
254 Eligible patients were aged 60-80 years with bulky stage 2-3 or stage 3-4 CD20-positive diffuse large
256 self-stimulate these inputs, indicating that bulky stimulation of these fibers are rewarding in the s
258 protein cross-links (DPCs) are exceptionally bulky, structurally diverse DNA adducts formed in cells
260 s with styrenes below room temperature, only bulky styrenes lead to tractable aziridino products.
261 oportionate H2O2 in aqueous solution; with a bulky substituent (R=tBu), this catalytic reaction is sh
262 nal design of hindered urea bonds (urea with bulky substituent attached to its nitrogen) and the use
264 ,3-diimines by C-C-bond-formation in case of bulky substituents at the ketenimine-nitrogen atom.
265 tional studies suggested the introduction of bulky substituents at the terminal portion of the pyrrol
267 gand can exert a stereoelectronic influence: bulky substituents destabilize the HOMO, thereby increas
269 ine with the proposed associative mechanism, bulky substituents slow the reaction in the order Me < E
270 sensitive to ATP-competitive inhibitors with bulky substituents that complement this expanded binding
271 evelopments were made possible by the use of bulky substituents that provide kinetic and thermodynami
277 ctive site when it harbors phosphomimetic or bulky substitutions at Ser(359.) In contrast, PKCdelta-S
278 l features, which identify enzymes acting on bulky substrates as a distinct subgroup of the BVMO clas
280 gy to discourage aggregation means that less bulky systems (for example, containing a primary alkylid
282 ere systematically more stabilizing with the bulky tBu group forming the strongest stabilizing intera
283 methodology towards selective recognition of bulky templates such as proteins appears to be extremely
284 ivity are maintained upon replacement of the bulky tert-butyl substituents on the ligands with methyl
285 ed 2-O-glycosylated glucosyl donors carrying bulky tert-butyldimethylsilyl groups to different extent
287 f this work is to demonstrate how the use of bulky thiolate ligands, such as adamantanethiol, versus
289 ISA incubation and reading are expensive and bulky, thus cannot be used at point-of-care or in the fi
296 ky normal muscle tissues, we further created bulky tumor model with VX2 tumors implanted on both hind
299 re was applied to the synthesis of (a)chiral bulky unsymmetrical unsaturated 2,6-diisopropylphenyl N-
300 feasibility to enhance tumor permeability in bulky VX2 tumors in a rabbit model using pHIFU technique
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