ライフサイエンスコーパス: bungarotoxin

1 fter daily intramuscular injections of alpha-bungarotoxin.

2 4-azidobenzoimidate derivative of 125I-alpha-bungarotoxin.

3 e the initial rate of binding for 125I-alpha-bungarotoxin.

4 ersible acetylcholine receptor blocker alpha-bungarotoxin.

5 toxin and were blocked using unlabeled alpha-bungarotoxin.

6 eurofilaments, as well as with labeled alpha-bungarotoxin.

7 on of the flexible tip of finger II in alpha-bungarotoxin.

8 the muscle fibers, as demonstrated by alpha-bungarotoxin.

9 use strains were found to bind [(125)I]alpha-bungarotoxin.

10 meable to calcium, and avid binders of alpha-bungarotoxin.

11 en K(+) and Na(+), and were blocked by alpha-bungarotoxin.

12 as blocked by the selective antagonist alpha-bungarotoxin.

13 release and are sensitive to block by alpha-bungarotoxin.

14 bunit, and a fluorescent derivative of alpha-bungarotoxin.

15 idine, or the alpha7 nAChR antagonist, alpha-bungarotoxin.

16 ing of the alpha7-selective antagonist alpha-bungarotoxin.

17 of lower-affinity sites insensitive to alpha-bungarotoxin.

18 nding sites sensitive to inhibition by alpha-bungarotoxin.

19 IP3Rs were modulated by extracellular alpha-bungarotoxin.

20 HbetaE (50% with 1000 nmol) but not by alpha-bungarotoxin (0% at 0.63 nmol).

21 oM), methyllycaconitine (1 microM) and alpha-bungarotoxin (1 microM) afforded no protection when pres

22 containing alpha3beta4 subunits, then alpha-bungarotoxin (1 microm), an antagonist for nicotinic rec

23 Perfusion of the ganglion with alpha-bungarotoxin (1 micrometer, which blocks alpha7 receptor

24 the alpha 7 nAChR-specific antagonist alpha-bungarotoxin (100 nM), but not by mecamylamine (50 micro

25 ycaconitine (1 nM) and irreversibly by alpha-bungarotoxin (100 nM), consistent with the expression of

26 Unlike [(125)I]alpha-bungarotoxin, [(125)I]alpha-conotoxin MI binding to TE67

27 use a combination of mecamylamine and alpha-bungarotoxin; (4) since mecamylamine and alpha-bungaroto

28 kappa-Bungarotoxin, a kappa-neurotoxin derived from the venom

29 ormed between this cognate peptide and alpha-bungarotoxin, a long alpha-neurotoxin.

30 ivity colocalized with the staining of alpha-bungarotoxin, a marker of the NMJ.

31 Beta-bungarotoxin, a neurotoxic phospholipase A2 is a major f

32 ered or eliminated, or when transgenic alpha-bungarotoxin, a nicotinic acetylcholine receptor antagon

33 They are blocked by kappa-bungarotoxin, a specific antagonist of the AChR isotypes

34 al microscopy and flow cytometry using alpha-bungarotoxin, a specific antagonist.

35 alpha-Bungarotoxin affinity purification or immunoprecipitatio

36 veals distinctive spectral changes for alpha-bungarotoxin, agonists, and alkaloid antagonists.

37 0; beta2-containing sites), and (125)I-alpha-bungarotoxin (alpha 7-containing sites) binding in brain

38 ubtype that is functionally blocked by alpha-bungarotoxin (alpha Bgt) and contains the alpha7 subunit

39 ylcholine receptors (nAChRs) that bind alpha-bungarotoxin (alpha Bgt) were studied on isolated rat su

40 alpha-bungarotoxin (alpha7 nAChR) and kappa-bungarotoxin (alpha(x)beta(y) nAChR) to the mobile phase

41 Using [(125)I] alpha-bungarotoxin (alpha-BGT) autoradiography, alpha7 express

42 he alpha7 subtype of nAChR with either alpha-bungarotoxin (alpha-BGT) or methyllycaconitine (MLA) cou

43 nal antibody (mAb35), which recognizes alpha-bungarotoxin (alpha-Bgt)-insensitive nAChRs, and a polyc

44 AChRs that binds the snake venom toxin alpha-bungarotoxin (alpha-Bgt-AChRs) has been shown to modulat

45 are in a position to contribute to the alpha-bungarotoxin (alpha-Bgtx) binding site, little is known

46 e receptor (AChR) that are involved in alpha-bungarotoxin (alpha-Bgtx) binding.

47 alpha-bungarotoxin (alpha-BgTx) selectively blocked the nAChR-

48 hR) family have demonstrated that this alpha-bungarotoxin (alpha-BgTx)-binding neuronal receptor can

49 alpha-Bungarotoxin (alpha-bgtx)-binding proteins, including ce

50 arried by nAChRs that are sensitive to alpha-bungarotoxin (alpha-BgTx).

51 anti-somatostatin, we determined that alpha-bungarotoxin (alpha-btx) at 12.5 microg/day rescued only

52 The hippocampus is a major target of alpha-bungarotoxin (alpha-BTX) binding.

53 alpha-Bungarotoxin (alpha-Btx) binds to the five agonist bindi

54 mpetition of cyclic imines with biotin-alpha-bungarotoxin (alpha-BTX) for binding to these proteins.

55 ine or phentolamine) or ACh (atropine, alpha-bungarotoxin (alpha-BTX) or scopolamine) blocks or atten

56 ges were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TNF-alph

57 ansmission is blocked by curare and by alpha-bungarotoxin (alpha-BTX).

58 -myotube co-cultures were blocked with alpha-bungarotoxin (alpha-BTX).

59 AChR)-blocking agents [e.g., curare or alpha-bungarotoxin (alpha-BTX)] prevents the death of MNs.

60 eptor (NnAChR) currents insensitive to alpha-bungarotoxin (alpha-BuTX-ICs) in cultured rat cortical n

61 dition of subtype-specific inhibitors, alpha-bungarotoxin (alpha7 nAChR) and kappa-bungarotoxin (alph

62 (125)I-alpha-bungarotoxin (alphaBGT) binding at the oocyte surface wa

63 Immunohistochemistry and in situ alpha-bungarotoxin (alphaBGT) binding showed that alpha7 nAChR

64 major nAChR types: those recognized by alpha-bungarotoxin (alphaBgt), nearly all of which contain onl

65 block, both the rapidly desensitizing, alpha-bungarotoxin (alphaBgt)-sensitive alpha7-AChRs and the s

66 itization and is reversibly blocked by alpha-bungarotoxin (alphaBgt).

67 alpha7 receptor-selective antagonists alpha-bungarotoxin (alphaBgTx) and methyllycaconitine.

68 molecular determinants responsible for alpha-bungarotoxin (alphaBgtx) binding to nicotinic acetylchol

69 that confers high-affinity binding of alpha-bungarotoxin (alphaBgTx) was established (alphaBgTx-5-HT

70 camylamine but was resistant to 100 nm alpha-bungarotoxin (alphaBgTx).

71 chicks, nicotinic antagonists such as alpha-bungarotoxin (alphaBT) can prevent normal cell death of

72 erved for the AChR in complex with two alpha-bungarotoxin (alphaBTX) molecules.

73 pretreated with the alpha7 antagonist alpha-bungarotoxin (alphaBTX) or transfected with anti-alpha7

74 ially blocked in wild-type cultures by alpha-bungarotoxin, an antagonist of the alpha7 nAChR subtype,

75 ibronectin expression was abolished by alpha-bungarotoxin, an inhibitor of alpha7 nicotinic acetylcho

76 0) > 10 microM) interacted with (125)I-alpha-bungarotoxin and (-)-[(3)H]nicotine binding sites, confi

77 stoichiometric complex formed between alpha-bungarotoxin and a recombinantly expressed 19-mer peptid

78 t that C-terminal cationic residues of alpha-bungarotoxin and alpha-cobratoxin contribute significant

79 The alpha9alpha10 nAChR antagonists, alpha-bungarotoxin and alpha-conotoxin RgIA, blocked efferent-

80 ChR antagonists methyllycaconitine and alpha-bungarotoxin and by a desensitizing concentration of the

81 ist (epibatidine) and two antagonists (alpha-bungarotoxin and d-tubocurarine).

82 ntains high affinity binding sites for alpha-bungarotoxin and for autoimmune antibodies in sera of pa

83 locked by the alpha7nAChR antagonists, alpha-bungarotoxin and mecamylamine, and by specific siRNA-med

84 cal ganglionic cells was attenuated by alpha-bungarotoxin and methyllycaconitine but not by dihydro-b

85 nse, but unlike the neuronal receptor, alpha-bungarotoxin and methyllycaconitine not only failed to b

86 The faster component was blocked by alpha-bungarotoxin and methyllycaconitine, suggesting that rec

87 cent competitive assays involving ImI, alpha-bungarotoxin and nicotine using MDM and the murine macro

88 of native alpha7nAChR, including binding to bungarotoxin and positive allosteric modulators specific

89 labelling of intact cells with (125)I-alpha-bungarotoxin and precipitation with an epsilon-subunit-s

90 ies and irreversibility of binding for alpha-bungarotoxin and similar snake alpha-neurotoxins also ta

91 P1 on using Alexa Fluor 488 conjugated alpha-bungarotoxin and SK2 immunohistochemistry.

92 By sequentially labeling AChRs with biotin-bungarotoxin and streptavidin-fluorophore conjugates, we

93 at -60 mV, were blocked reversibly by alpha-bungarotoxin and strychnine and are most likely mediated

94 (38), Val(39), Val(40), and Pro(69) in alpha-bungarotoxin and Tyr(189), Tyr(190), Thr(191), Cys(192),

95 myotubes were identified with labeled alpha-bungarotoxin and were blocked using unlabeled alpha-bung

96 the absence of agonist or presence of alpha-bungarotoxin and with a K(eq) value of 30 microM in the

97 at several classes of neurotoxins, including bungarotoxins and cobratoxins, retain their selective an

98 inding studies ([(3)H]cytisine, (125)I-alpha-bungarotoxin, and (125)I-alpha-conotoxin MII) suggest th

99 tinic antagonists, methyllycaconitine, alpha-bungarotoxin, and alpha-cobratoxin, markedly restricts t

100 ts, which were blocked irreversibly by alpha-bungarotoxin, and with slowly desensitizing currents, wh

101 were blocked by methyllycaconitine and alpha-bungarotoxin, antagonists that are selective for nAChRs

102 ngarotoxin; (4) since mecamylamine and alpha-bungarotoxin are known to block nicotinic receptors cont

103 late wells and the use of biotinylated-alpha-bungarotoxin as tracer.

104 e alpha7 receptor-selective antagonist alpha-bungarotoxin as well as hippocampal auditory gating char

105 ChR antagonists methyllycaconitine and alpha-bungarotoxin, as well as by small interfering RNA knockd

106 eptors (AChRs) were determined by 125I alpha-bungarotoxin assay; and the level of expression of AChR

107 ion 178 yields a large blue shift with alpha-bungarotoxin association, whereas the agonists and alkal

108 ceptor (nAChR) alpha1 subunit bound to alpha-bungarotoxin at 1.94 A resolution.

109 domain of the alpha7 receptor, places alpha-bungarotoxin at the peripheral surface of the inter-subu

110 omologous nicotinic ACh receptors bind alpha-bungarotoxin at their ACh binding sites.

111 RNA and protein, as measured by (125)I alpha-Bungarotoxin autoradiography.

112 which are part of overlapping ACh and alpha-bungarotoxin (Bgt) binding sites on AChRs, were assayed

113 ype subunits prevents the formation of alpha-bungarotoxin (Bgt) binding sites.

114 7; ACh, nicotine or muscarine; ACh and alpha-bungarotoxin (Bgt) or methyllycaconitine (MLA); and glut

115 GABAA receptors that are capable of binding -bungarotoxin (Bgt), facilitating the visualization of re

116 Evidence is presented that alpha-bungarotoxin (Bgt)-binding nicotinic receptors found in

117 s demonstrate saturable, high-affinity alpha-bungarotoxin (Bgtx) binding with an apparent equilibrium

118 ine tag was added to the N-terminus of alpha-bungarotoxin (Bgtx) recombinantly expressed in E. coli.

119 show that acetylcholine, nicotine, and alpha-bungarotoxin bind to ct-AChBP with high affinity, with K

120 the wild type as measured by iodinated alpha-bungarotoxin binding ([(125)I]-alpha-BgTx).

121 ant AChR subunits, we show, using 125I-alpha-bungarotoxin binding and immunofluorescence to measure c

122 Using alpha-bungarotoxin binding and quantitative PCR and PCR produc

123 Data from (125)I-alpha-bungarotoxin binding assays indicate that cocaine methio

124 racterized by a dense, diffuse band of alpha-bungarotoxin binding at the CA3/CA1 border in the adult.

125 nificant differences in tectal [(125)I]alpha-bungarotoxin binding between tadpoles and adults.

126 , brain region specific differences in alpha-bungarotoxin binding between the mouse strains C3H/Ibg a

127 e optic nerve decreased tectal [(125)I]alpha-bungarotoxin binding by 33+/-10%, but 6-month lesions ha

128 alpha-Bungarotoxin binding had little effect on the frictional

129 Variations in alpha-bungarotoxin binding have been shown to correlate with a

130 At postnatal day 14, levels of [125I]alpha-bungarotoxin binding in layer IV were very low in contro

131 Accordingly, we examined alpha-bungarotoxin binding in mouse somatosensory cortex follo

132 dition, (125)I-epibatidine and [(125)I]alpha-bungarotoxin binding in the brains of alpha 5-deficient

133 significantly higher (14 +/- 3%) [125I]alpha-bungarotoxin binding in the contralateral vs. the ipsila

134 eristics of [(3)H]cytisine and [(125)I]alpha-bungarotoxin binding in the frog brain were similar to t

135 rast, there was no difference in [125I]alpha-bungarotoxin binding in the left and right cortices of u

136 genotype and individual differences in alpha-bungarotoxin binding levels in adult brain might be due

137 ed the linkage of Chrna7 genotype with alpha-bungarotoxin binding levels in hippocampus, striatum, an

138 that this subunit is a component of an alpha-bungarotoxin binding nicotinic acetylcholine receptor fr

139 vibrissa plucking, the levels of [125I]alpha-bungarotoxin binding on postnatal day 6 were significant

140 After introduction of an alpha-bungarotoxin binding site near the pore, PM IP3Rs were m

141 -containing GABA(A)Rs, we inserted the alpha-bungarotoxin binding site tag in the alpha(4), beta(2),

142 Successful bungarotoxin binding site tagging of GABA(A)R subunits i

143 sma membrane of alpha2delta-2 using an alpha-bungarotoxin binding site-tagged alpha2delta-2 subunit,

144 In addition, alpha-bungarotoxin binding sites (indicating nicotinic recepto

145 at can assemble to form (125)I-labeled alpha-bungarotoxin binding sites expressed on the cell surface

146 Mab 131 blocked one of the two alpha-bungarotoxin binding sites on the fetal AChR, and partia

147 [3H]Cytisine and 125I-alpha-bungarotoxin binding sites were eliminated by beta2 and

148 In contrast, (125)I-alpha-bungarotoxin binding sites were not altered after nigros

149 the number of surface Alexa Fluor 488 alpha-bungarotoxin binding sites.

150 cific activity of 3.9 micromol of 125I-alpha-bungarotoxin binding sites/g of protein.

151 nce, containing residues important for alpha-bungarotoxin binding to alpha1, confers functional alpha

152 their competition against 125I-labeled alpha-bungarotoxin binding to homomeric receptors containing a

153 of [(1)(2)(5)I]-epibatidine or [(1)(2)(5)I]-bungarotoxin binding to nicotinic ACh receptors (nAChRs)

154 ty in area CA1 and is characterized by alpha-bungarotoxin binding to numerous Nissl-stained structure

155 Our findings argue that alpha-bungarotoxin binding to the pharmatope, inserted at a su

156 ins competitively inhibit biotinylated-alpha-bungarotoxin binding to Torpedo-nicotinic acetylcholine

157 rain or in muscarinic M(2) receptor or alpha-bungarotoxin binding within the cortex.

158 nopus oocytes was measured by [(125)I]-alpha-bungarotoxin binding, and ACh receptor function was eval

159 hR currents, autoradiography of [125I]-alpha-bungarotoxin binding, and in situ hybridization revealed

160 is linked to individual differences in alpha-bungarotoxin binding, but not alpha7 RNA levels, suggest

161 ally, the number of AChRs, measured by alpha-bungarotoxin binding, is reduced to 10-30% of normal lev

162 ynthesis, cell-surface trafficking, or alpha-bungarotoxin binding.

163 cell patch clamp recording and surface alpha-bungarotoxin binding.

164 re was a comparable increase in (125)I-alpha-bungarotoxin binding.

165 ion against the initial rate of (125)I-alpha-bungarotoxin binding.

166 ion against the initial rate of (125)I-alpha-bungarotoxin binding.

167 ition against the initial rate of 125I-alpha-bungarotoxin binding.

168 ceptor measured by competition against alpha-bungarotoxin binding.

169 r acetylcholine esterase or conjugated alpha-bungarotoxin binding.

170 notype is associated with the level of alpha-bungarotoxin binding.

171 ylcholine and nicotine) or antagonist (alpha-bungarotoxin) binding.

172 te or inhibit cell-surface delivery of alpha-bungarotoxin-binding nAChRs (BgtRs) composed of alpha7 s

173 of Drosophila melanogaster contains an alpha-bungarotoxin-binding protein with the properties expecte

174 onal processing to produce functional, alpha-bungarotoxin-binding receptors with two alpha7 conformat

175 By using live imaging, with an alpha-bungarotoxin-binding site (BBS) and fluorophore-linked b

176 mation coincides with the formation of alpha-bungarotoxin-binding sites and intrasubunit disulfide bo

177 alpha-Conotoxin ImI and alpha-bungarotoxin-binding sites have been well characterized

178 Our results indicate that there are two bungarotoxin-binding sites in neuromuscular junction rec

179 individual receptors and count the number of bungarotoxin-binding sites in receptors expressed in HEK

180 lectrically silent by tetrodotoxin and alpha-bungarotoxin block were frequently displaced by regenera

181 alpha7-containing receptors, mimicked alpha-bungarotoxin blockade.

182 determined by quantitating fluorescent alpha-bungarotoxin bound to each subunit on Western blots of s

183 igher affinity compared to the resting/alpha-bungarotoxin-bound AChR, (e) binds to the Torpedo AChR i

184 a fluorescein-conjugated polypeptide, alpha-bungarotoxin (BTX) and a 13 amino acid BTX-binding site

185 We studied [(125)I]alpha-bungarotoxin (btx) binding to alpha7 nicotinic acetylcho

186 e in cortical and hippocampal alpha-[(125)I]-bungarotoxin (BTX) binding.

187 The polypeptide snake toxin alpha-bungarotoxin (BTX) has been used in hundreds of studies

188 king with subunits tagged with a 13-aa alpha-bungarotoxin (BTX)-binding site (BBS).

189 t was blocked by pre-administration of alpha-bungarotoxin but not di-hydro-beta-erythroidine.

190 by intracerebroventricular infusion of alpha-bungarotoxin, but not by mecamylamine or dihydro-beta-er

191 contact and were blocked by curare and alpha-bungarotoxin, but not by TTX and Cd(2+), suggesting that

192 c removal of single disulfide bonds in kappa-bungarotoxin by site-specific mutagenesis reveals a diff

193 blocked by an alpha7 nAChR antagonist (alpha-bungarotoxin), by alpha7 nAChR short interfering RNA, an

194 tinic acetylcholine receptor inhibitor alpha-bungarotoxin can block nicotine-induced calpain phosphor

195 voltage-clamp analysis and/or by [125I]alpha-bungarotoxin competition binding assays the interactions

196 esidue peptide in a tight complex with alpha-bungarotoxin conforms to the beta hairpin structure of a

197 block of acetylcholine receptors with alpha-bungarotoxin decreases acetylcholine receptor number wit

198 ated to the alpha-neurotoxins, such as alpha-bungarotoxin derived from the same snake, which are mono

199 te, along with a lack of inhibition by alpha-bungarotoxin directed to the alpha subunit correlated wi

200 otomes by labeling them with rhodamine-alpha-bungarotoxin followed by confocal microscopy and image a

201 The peptide competes with alpha-bungarotoxin for binding at the alpha/delta and alpha/ga

202 Azemiopsin efficiently competed with alpha-bungarotoxin for binding to Torpedo nicotinic acetylchol

203 Rs, but not by a selective antagonist, alpha-bungarotoxin, for alpha7-nAChRs.

204 d by dihydro-beta-erythroidine whereas alpha-bungarotoxin had no effect on response amplitude to eith

205 RNA and as components of 125I-labeled alpha-bungarotoxin (I-Bgt)-binding nAChR ( approximately 10 pm

206 dicate that [(3)H]cytisine and [(125)I]alpha-bungarotoxin identify distinct nAChR subtypes in the tec

207 In alpha-bungarotoxin-immobilized tadpoles, intracellular recordi

208 -related decreases in the postterminal alpha-bungarotoxin immunostained area, as well as the reductio

209 desensitizes slowly and is blocked by alpha-bungarotoxin in a rapidly reversible manner.

210 Specific binding of [(125)I]alpha-bungarotoxin in adults was present only at intermediate

211 ing and autoradiography using [(125)I] alpha-bungarotoxin in the DLPFC.

212 binding of [(3)H]cytisine and [(125)I]alpha-bungarotoxin in the laminated tectum.

213 tion of the nicotinic receptor blocker alpha-bungarotoxin increased BBB permeability in brain-injured

214 ceptors by perfusing the ganglion with alpha-bungarotoxin induced failures in synaptic transmission.

215 owly desensitizing currents, which are alpha-bungarotoxin-insensitive currents.

216 n-sensitive, alpha 7-type currents and alpha-bungarotoxin-insensitive, alpha 4 beta 2-type currents.

217 ensitizing (alpha 7-type) currents and alpha-bungarotoxin-insensitive, slowly desensitizing (alpha 4

218 , Val(39), and Val(40) in finger II of alpha-bungarotoxin interface with Phe(186), Tyr(187), Glu(188)

219 acute, reversible denervation caused by beta-bungarotoxin is a credible explanation for the clinicall

220 kappa-Bungarotoxin is a potent, selective, and slowly reversib

221 kappa-Bungarotoxin is structurally related to the alpha-neurot

222 The disulfide-rich core of alpha-bungarotoxin is suggested to be tilted in the direction

223 it formed a high affinity complex with alpha-bungarotoxin (k(D) 0.2 nm) but showed relatively low aff

224 panied by some dramatic changes in the alpha-bungarotoxin-labeled ACh post-synaptic receptor elements

225 y after photobleaching (FRAP) on fluorescent bungarotoxin-labeled receptors, we found that approximat

226 The distribution of [(125)I]alpha-bungarotoxin labeling closely resembled the DBA/2 parent

227 ed linkage between Chrna7 genotype and alpha-bungarotoxin levels may be due to genetic influences on

228 Vertebrate alpha-bungarotoxin-like molecules of the Ly-6 superfamily have

229 rearrangements in flexible regions of alpha-bungarotoxin, mainly loops I, II, and the C-terminal tai

230 of Abeta was found to be sensitive to alpha-bungarotoxin, mecamylamine, and dihydro-beta-erythroidin

231 9'Lys(BODIPYFL) receptors labeled with alpha-bungarotoxin monoconjugated with Alexa488 (alphaBtxAlexa

232 Neuronal bungarotoxin (NBT) is a highly selective, slowly reversi

233 eir equilibrium binding affinities for alpha-bungarotoxin, nicotine, and acetylcholine, combined with

234 TTX, voltage-gated sodium blocker, or alpha-bungarotoxin, nicotinic acetylcholine receptor antagonis

235 ies the robust axotomy-like effects of alpha-bungarotoxin on motoneuron excitability, and the low lev

236 tudied in cell monolayers treated with alpha-bungarotoxin or antisense oligonucleotides and in the sk

237 onists of nicotinic receptors, such as alpha-bungarotoxin or mecamylamine, only partially reversed th

238 nels, and then were tested with either alpha-bungarotoxin or methyllycaconitine, which are selective

239 These effects were not seen when alpha-bungarotoxin or PNU-282987 were administered to splenect

240 e alpha7 nicotinic receptor antagonist alpha-bungarotoxin or the alpha4beta2 nicotinic receptor antag

241 nic acetylcholine receptor antagonist, alpha-bungarotoxin, or the alpha4beta2 nicotinic acetylcholine

242 ockade of acetylcholine receptors with alpha-bungarotoxin over the same time interval produced change

243 Furthermore, its abundant bungarotoxin-positive acetylcholinesterase receptors are

244 wever, the distribution of the [(125)I]alpha-bungarotoxin-positive hippocampal interneurons was signi

245 mice had increased numbers of [(125)I]alpha-bungarotoxin-positive neurons in stratum lacunosum-molec

246 was blocked by methyllycaconitine and alpha-bungarotoxin (preferential alpha7-nAChR antagonists) and

247 ges are those having high affinity for alpha-bungarotoxin rather than epibatidine.

248 ic acetylcholine receptor subtype, the alpha-bungarotoxin receptor (alpha Bgt), in the CN.

249 Neuronal alpha-bungarotoxin receptors (BgtRs) are nicotinic receptors t

250 Functional alpha-bungarotoxin receptors are expressed if the membrane-spa

251 in the postsynaptic membrane, whereas alpha-bungarotoxin receptors composed of alpha 7 subunits are

252 rtially reduced cytisine-resistant and alpha-bungarotoxin-resistant sites with lower and higher affin

253 The binding of radiolabeled alpha-bungarotoxin revealed a few thousand binding sites per c

254 ic studies indicated that alpha-Ctx or alpha-bungarotoxin seem to interact with GABAAR in a way simil

255 Inhibition of 383C binding by alpha-bungarotoxin selectively directed to the alpha subunit c

256 iated rescue through the activation of alpha-bungarotoxin-sensitive (presumably alpha7) nicotinic rec

257 NF synthesis is dependent on nicotinic alpha-bungarotoxin-sensitive acetylcholine receptors on macrop

258 ive alpha9alpha10 nAChRs compared with alpha-bungarotoxin-sensitive alpha7 receptors.

259 ayed a 260-fold higher selectivity for alpha-bungarotoxin-sensitive alpha9alpha10 nAChRs compared wit

260 e cultured Kenyon cells are mediated byalpha-bungarotoxin-sensitive nAChRs or picrotoxin-sensitive GA

261 nyon cells, fast EPSCs are mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors

262 the primary postsynaptic receptors are alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors

263 Among neuronal non-alpha-bungarotoxin-sensitive receptors, alpha-conotoxin PeIA w

264 ts were evoked by acetylcholine (ACh): alpha-bungarotoxin-sensitive, alpha 7-type currents and alpha-

265 ACh evoked two types of currents, alpha-bungarotoxin-sensitive, fast desensitizing (alpha 7-type

266 binding to alpha1, confers functional alpha-bungarotoxin sensitivity when strategically placed into

267 ebrafish can be achieved with tethered alpha-bungarotoxin, silencing synaptic transmission without pe

268 three-finger toxins (TFT) or from the kappa-bungarotoxin solution structure.

269 its and monkeys and were visualized by alpha-bungarotoxin staining and three-dimensional reconstructi

270 ne of cells lacking ric-3, but surface alpha-bungarotoxin staining was only observed in cells co-expr

271 lization with immunohistochemistry and alpha-bungarotoxin staining.

272 A comparison of the free and bound alpha-bungarotoxin structures reveals significant conformation

273 ew, higher resolution NMR structure of alpha-bungarotoxin that defines the structure-determining disu

274 Expressing alpha-bungarotoxin that is tethered to the membrane by a glyco

275 mammalian prototoxin lynx1 shares with alpha-bungarotoxin the ability to bind and modulate nicotinic

276 alpha-Bungarotoxin, the classic nicotinic antagonist, has high

277 I was not able to block the binding of alpha-bungarotoxin to alpha7 nAChRs.

278 The binding of [125I]alpha-bungarotoxin to brain sections also was decreased in SHR

279 We used alpha-bungarotoxin to compare neuromuscular junction (NMJ) mor

280 We have used fluorescently labeled alpha-bungarotoxin to image alpha7-containing receptors on hip

281 In the nAChR equilibrated with alpha-bungarotoxin to stabilize the nAChR in a closed state, [

282 Assessment of hippocampal alpha-bungarotoxin to visualize nicotinic alpha7 receptors rev

283 old) in the nicotinic receptor binding alpha-bungarotoxin (to the alpha7 subunit) which reached signi

284 We used [3H]epibatidine and 125I-alpha-bungarotoxin, together with subunit-specific monoclonal

285 stribution of AChRs labeled with fluorescent bungarotoxin was imaged at various time points over >24

286 nsitivity to inhibition by cytisine or alpha-bungarotoxin was used to evaluate pharmacological subset

287 he presence of either acetylcholine or alpha-bungarotoxin was used to test for the functional activit

288 eling the receptors with fluorophore-labeled bungarotoxin, we can image individual receptors and coun

289 n bind other alpha-neurotoxins besides alpha-bungarotoxin, we designed a two-dimensional (1)H-(15)N h

290 nd relabeling with different colors of alpha-bungarotoxin, we selectively labeled adjacent pools of a

291 in-binding site (BBS) and fluorophore-linked bungarotoxin, we studied how R2 stabilizes R1b subunits

292 mplexes that neither function nor bind alpha-bungarotoxin when expressed in tsA201 cells.

293 ivated by acetylcholine and blocked by alpha-bungarotoxin when expressed in Xenopus laevis oocytes.

294 the selective alpha7-nAChR antagonist alpha-bungarotoxin, whereas other selective antagonists did no

295 Mecamylamine and kappa-bungarotoxin, which are cholinergic antagonists able to

296 nicotinic receptor antagonist [(125)I]-alpha-bungarotoxin, which binds to alpha7 subunit containing n

297 could be abolished by mecamylamine and alpha-bungarotoxin with different efficacies, suggesting the f

298 could be abolished by mecamylamine and alpha-bungarotoxin with different efficacies, suggesting the f

299 oduct, rapidly desensitizes, and binds alpha-bungarotoxin with great affinity.

300 hare many structural features and bind alpha-bungarotoxin with high affinity, several important funct