ライフサイエンスコーパス: bunyavirus

1 ine encephalitis virus, as well as La Crosse bunyavirus.

2 ver epithelial cells infected by an emerging bunyavirus.

3 may be implicated in the replication of SFTS bunyavirus.

4 onstration of foreign gene expression in any bunyavirus.

5 attractive strategy to rationally attenuate bunyaviruses.

6 ountermeasure development against pathogenic bunyaviruses.

7 Our findings suggest an arthropod origin of bunyaviruses.

8 he evolutionary connections that exist among bunyaviruses.

9 al activity against orthomyxoviruses but not bunyaviruses.

10 T=12 icosahedral organization found for some bunyaviruses.

11 gments are copackaged to generate infectious bunyaviruses.

12 challenged with closely related heterologous bunyaviruses, a similar inhibitory effect was seen.

13 We propose a model where bunyaviruses activate Wnt-responsive genes to regulate o

14 ly been reported only for Uukuniemi virus, a bunyavirus also within the Phlebovirus genus.

15 e evaluation of RNAs extracted from selected bunyaviruses and other representative arthropod-borne vi

16 flaviviruses, alphaviruses, picornaviruses, bunyaviruses, and coronaviruses.

17 Bunyaviruses are considered to be emerging pathogens fac

18 Bunyaviruses are transmitted via a diverse range of arth

19 The majority of bunyaviruses are vectored by arthropods and thus have th

20 activity against numerous viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronavirus

21 ection using flaviviruses, alphaviruses, and bunyaviruses as examples of emerging pathogens of global

22 are shown to be orthomyxoviruses instead of bunyaviruses, as previously thought.

23 SFTS virus is novel bunyavirus associated with hemorrhagic fever illness.

24 merica, both previously considered potential bunyaviruses based on electron microscopy and physicoche

25 For the prototype bunyavirus, Bunyamwera virus (BUNV), only the terminal 1

26 at the closest CCHFV relative is not another bunyavirus but the arenavirus Lassa virus instead, sugge

27 filoviruses, flaviviruses, arenaviruses, and bunyaviruses, cause hemorrhagic fevers.

28 RNA viruses such as Orthomyxo-, Arena-, and Bunyaviruses coats the genomic viral RNA and together wi

29 f highly attenuated yet immunogenic chimeric bunyaviruses could be an efficient general method for de

30 Bunyaviruses deliver their genome into the host-cell cyt

31 lass for the treatment of potentially lethal bunyavirus disease.

32 se findings provide the first description of bunyavirus entry into cells of the central nervous syste

33 d RNA viruses from Ortho-, Filo-, Flavi- and Bunyavirus families, for which there is no FDA-approved

34 (RVFV), a mosquito-transmitted virus in the bunyavirus family that causes severe morbidity and morta

35 Members of the California serogroup of bunyaviruses (family Bunyaviridae) are the leading cause

36 In this study, we found that the bunyavirus Gc glycoprotein is a virulence factor.

37 ical protein with a fold distinct from other bunyavirus genera NPs.

38 que conserved genome termini, as in separate bunyavirus genera.

39 viruses from the Alphavirus, Flavivirus, and Bunyavirus genera.

40 nslated regions (UTR) present at the ends of bunyavirus genome segments are required for essential st

41 We define two cardinally novel bunyavirus groups based on live isolation of 26 viral st

42 The genomes of 2 novel bunyaviruses (>99% complete) in the genera Nairovirus an

43 Bunyaviruses have a truly global distribution and can in

44 Bunyaviruses have an outer lipid envelope bearing two gl

45 Toscana virus is an emerging bunyavirus in Mediterranean Europe where it accounts for

46 CCHF virus (CCHFV), a bunyavirus in the Nairovirus genus, is capable of infect

47 The high prevalence of these bunyaviruses in sampled Dermacentor ticks suggests that

48 bserved for RVFV, along with other disparate bunyaviruses, indicating a conserved bunyaviral replicat

49 interaction with GAGs is not universal among bunyaviruses, indicating that these viruses, as well as

50 r knowledge of the fundamental mechanisms of bunyavirus infection and provide new avenues for counter

51 To define the role of IRF-5 during bunyavirus infection, we evaluated Oropouche virus (OROV

52 nti-viral therapies available to treat human bunyavirus infections and so development of new anti-vir

53 Severe fever with thrombocytopenia syndrome bunyavirus is a newly discovered bunyavirus with high pa

54 La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephal

55 characterization of emergent arthropod-borne bunyavirus isolates of medical import as well as related

56 For bunyaviruses, it has been well documented that the nonst

57 r results were found using distantly related bunyaviruses La Crosse virus and California encephalitis

58 In addition, some well-known bunyaviruses like Rift Valley fever and Crimean-Congo ha

59 channel dependence was identified for other bunyaviruses namely Schmallenberg virus (Orthobunyavirus

60 response in peripheral organs that controls bunyavirus neuroinvasion in mice.

61 RNA encapsidation and protection function of bunyavirus NP, but also highlights the need for dynamic

62 Independent of caspase activation, Bunyavirus NSs proteins also share with Reaper the abili

63 Thus, bunyavirus NSs proteins have multiple Reaper-like functi

64 rast to reports that Bunyamwera virus (genus Bunyavirus) NSs protein inhibits viral minigenome RNA sy

65 The bunyavirus nucleocapsid protein, N, plays a central role

66 er RT-PCR amplification, DNAs amplified from bunyaviruses of interest were subjected to a novel multi

67 RNAs extracted from quantitated dilutions of bunyaviruses of interest.

68 Many bunyaviruses of the Bunyamwera and California serogroups

69 za A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1.

70 novel multiplex sequencing method to confirm bunyavirus positivity and provide preliminary, species-l

71 Here, we evaluated bunyavirus replication, tissue tropism, and cytokine pro

72 To identify host factors involved in bunyavirus replication, we employed genome-wide RNA inte

73 a safe laboratory model to study aspects of bunyavirus replication.

74 TS) is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic in central and northea

75 The mosquito-transmitted bunyavirus, Rift Valley fever virus (RVFV), is a highly

76 epresents a newly described architecture for bunyavirus RNP assembly, with implications for many othe

77 s (BUNV; genus Orthobunyavirus) is the model bunyavirus, sharing aspects of its molecular and cellula

78 were genetically equidistant from all other bunyaviruses, showing <15% amino acid identity in the Rd

79 es such as influenza A and Thogoto virus and bunyaviruses such as La Crosse virus.

80 topenia syndrome (SFTS) virus is an emerging bunyavirus that causes a hemorrhagic fever with a high m

81 RVFV is a mosquito-borne bunyavirus that is endemic to Africa but has demonstrate

82 hlebovirus (SFTSV) is an emerging tick-borne bunyavirus that was first reported in China in 2009.

83 itive mutations, in the design of attenuated bunyaviruses that could have potential as vaccines.

84 tomato spotted wilt virus (a plant-infecting bunyavirus), the interferon antagonist protein NS1 of in

85 During maturation of the plant-infecting bunyavirus Tomato spotted wilt, Gc localizes at endoplas

86 d affinity to the panhandles from the genera Bunyavirus, Tospovirus, and Phlebovirus or Nairovirus.

87 mbocytopenia syndrome virus (SFTSV), a novel bunyavirus transmitted by ticks, is often associated wit

88 with arthropods at deep nodes throughout the bunyavirus tree.

89 11SB17, 11SB19 and 11SB23) reveals a typical bunyavirus tri-segmented genome.

90 gested ancient evolutionary divergence, with bunyavirus-typical morphology for FERV (spheres of 60-12

91 for reactivity with 44 viruses of the genus Bunyavirus, using a reverse transcriptase PCR technique.

92 f Old World and New World alphaviruses and a bunyavirus was reduced in mature compared to immature ne

93 d viral lineage showing strong affinities to bunyaviruses was termed "Leishbunyavirus" (LBV) and judg

94 ated GTPase capable of restricting growth of bunyaviruses, was elevated in the allantoic and amniotic

95 ia syndrome bunyavirus is a newly discovered bunyavirus with high pathogenicity to human.