ライフサイエンスコーパス: burst firing

1 aining dopamine neuron firing regularity and burst firing.

2 te single-spike activity rather than rebound burst firing.

3 n/soma but not dendritic excitation impaired burst firing.

4 ncreased the number and the length of phasic burst firing.

5 tion reduced firing rates but did not affect burst firing.

6 attern of dopamine release with nonburst and burst firing.

7 rizing current injections and during rebound burst firing.

8 lease with nonburst stimulation but not with burst firing.

9 ibited half the recorded neurons and blocked burst firing.

10 ons leads to long-lasting increases in their burst firing.

11 of dopamine neurons without altering phasic burst firing.

12 THIP hyperpolarized TC neurons and promoted burst firing.

13 ntial propagation along lateral dendrites by burst firing.

14 c GABA(A)Rs produced longer and more intense burst firing.

15 l firing pattern, promoting action potential burst firing.

16 which in many cells contributes to intrinsic burst firing.

17 ing patterns, such as single-spike and spike-burst firing.

18 that these two currents interact to regulate burst firing.

19 ulation in a pattern mimicking dopamine cell burst firing.

20 ivation of pedunculopontine inputs increased burst firing.

21 ed secondary range and long-duration rebound burst firing.

22 tex operate in two distinct modes, tonic and burst firing.

23 and most neurons did not exhibit changes in burst firing.

24 can boost distal synaptic inputs and promote burst firing.

25 ck, while having no effect on firing rate or burst firing.

26 olarization (AHP) and caused a transition to burst firing.

27 s observed including regular, irregular, and burst firing.

28 rate and reducing the threshold for rebound burst firing.

29 ods and permitting rapid, repetitive, and/or burst firing.

30 polarization amplitude and thereby promoting burst firing.

31 reased firing during singing and song-locked burst firing.

32 nd fully abolished hyperpolarization-induced burst firing.

33 (TRPM2) channels that underlie NMDA-induced burst firing.

34 s (NMDARs) and increasing permissiveness for burst firing.

35 ns, although only a minority (15%) exhibited burst firing.

36 pectively, and abnormal synchronous rhythmic burst firing.

37 lity of synapses to sustain responses during burst firing.

38 M-channels depolarized neurons and increased burst firing.

39 ological observations of dopaminergic neuron burst-firing.

40 howed two minima in all regular-spiking (5), burst-firing (3) and in many fast-spiking cells (17:28).

41 Of available drug targets, only burst firing achieves this essential outcome.

42 , interneurons exhibited a tonic, irregular, burst firing activity, or a combination of these.

43 Furthermore, the burst-firing activity characteristic of SNc mDA neurons

44 Given the near ubiquity of burst-firing activity patterns and CB1R expression in th

45 and complex (MS/DB) in vivo exhibit rhythmic burst-firing activity that is phase-locked with the hipp

46 n, increased firing frequency, and increased burst-firing activity.

47 during generalized clonus, which changed to burst firing after AGS kindling.

48 hannel types could underlie the emergence of burst firing after dopamine-depleting lesions.

49 rease was also induced by postsynaptic theta-burst firing alone, yet it was blocked by NMDA receptor

50 Burst firing also occurred during F and F clonus.

51 During F&F clonus, burst firing, an indicator of increased excitability, ap

52 Reduced inhibition could increase burst firing and action potential-dependent release of d

53 hibiting D5R constitutive activity depresses burst firing and alleviates motor impairments in the 6-O

54 inal nociceptive circuits generate intrinsic burst firing and are distinguished by a lower "leak" mem

55 could be a mechanism by which E2 facilitates burst firing and cyclic GnRH neurosecretion.

56 s within human MTL and confirm that neuronal burst firing and enhanced neuronal synchrony observed in

57 polarizations (AHPs); (iv) strongly enhanced burst firing and increased excitability at moderate spik

58 raclopride as well as saline did not reverse burst firing and motor deficits, confirming the selectiv

59 erating low-threshold spikes that facilitate burst firing and neurotransmitter release in neurons.

60 namic firing patters, including synchronized burst firing and pauses.

61 urrent caused the cessation of low-threshold burst firing and promoted tonic firing.

62 ZD7288 also altered the pattern of burst firing and reduced the slope of recovery from the

63 ical characteristics of SON neurons, such as burst firing and resistance to excitotoxicity.

64 ation of active dendritic signals that drive burst firing and robust plasticity.

65 Burst firing and single spike activity play different ro

66 ts bimodal control of mossy fiber-driven CA3 burst firing and spike temporal fidelity.

67 3 function by PIP(2) augmented low-threshold burst firing and spontaneous oscillations; conversely, d

68 Somatic IPSPs, dendritic burst firing and stratum pyramidale interneuron activity

69 dependent behaviors by attenuating DA neuron burst firing and subsequent DA release, without altering

70 hic pain is associated with altered thalamic burst firing and thalamocortical dysrhythmia.

71 neurons that contributes to action potential burst firing and that estradiol regulates I(h) in these

72 uggest that resonance in L2-3 PNs depends on burst firing and the mAHP.

73 be one mechanism by which estrogen augments burst firing and transmitter release in hypothalamic neu

74 T-type) calcium channels are responsible for burst firing and transmitter release in neurons and are

75 g low-threshold spikes (LTS) that facilitate burst firing and transmitter release in neurons.

76 d"), the same LMAN neurons exhibit prominent burst firing and trial-by-trial variability.

77 Furthermore, STN burst-firing and beta oscillations are two independent m

78 ng, we further demonstrated that over 60% of burst-firing and stutter-firing interneurons also expres

79 actions using model neurons in which somatic burst-firing and synaptic plasticity are controlled by c

80 cial for intrinsic excitability and rhythmic burst firing, and PIP(2) serves as a powerful modulator

81 eurons, including subthreshold oscillations, burst firing, and rebound excitation.

82 play a key role in neuronal excitability and burst firing, and selective triple T-type calcium channe

83 urones recorded were regular-spiking, 3 were burst-firing, and 7 were fast-spiking.

84 ic Ca(2+)-dependent K(+) current to generate burst firing are controversial.

85 Potentiation requires postsynaptic burst firing at 5 Hz or higher, a firing pattern that oc

86 2 or 4 spikes) high frequency (circa 100 Hz) burst firing at 5 or 10 Hz.

87 and nickel also suppressed LTS and neuronal burst firing at concentrations that blocked isolated T c

88 ich exhibit intrinsic rhythmic low-frequency burst firing at ~0.2-2 Hz.

89 f 4 regular-spiking bistratified, and 3 of 5 burst-firing basket cells were also PV-IR.

90 isodes of wakefulness (Aw), no difference in burst firing between epileptic and non-epileptic hippoca

91 CA3 pyramidal neurons (PYRs) exhibit intense burst firing (BF) early in development, concomitant with

92 t, PV interneuron silencing had no effect on burst firing, but instead shifted the spikes' theta phas

93 nt of external calcium by magnesium enhanced burst firing, but it was blocked by cobalt replacement o

94 pin-releasing hormone (GnRH) neurons exhibit burst firing, but the underlying conductances are not kn

95 pha1 receptors increases dopaminergic neuron burst firing by decreasing the calcium-activated potassi

96 cleotide-gated current (I(h)) contributes to burst firing by depolarizing the membrane after a period

97 reclassification also identifies generating burst firing by dopamine neurons as a keystone action.

98 to capitalize on the nicotine-induced phasic burst firing by dopamine neurons.

99 hold for nociceptor excitability and induces burst firing by increasing the amplitude of T-type curre

100 ed Ca(2+) channels also facilitated rhythmic burst firing by triggering intracellular Ca(2+) signalin

101 Our results show that burst firing can be evoked in dopamine neurons via two d

102 Here we report that burst firing can be regulated by stimulation of afferent

103 ctric fish to address how stimulus-dependent burst firing can determine the flow of information in fe

104 ether OT neurons from male rats also possess burst firing capability is still an open question.

105 = 16) and 28.7 +/- 5.8 ms in regular-spiking/burst-firing cells (n = 6), and the benzodiazepine1-sele

106 drites; a proportion of the fast-spiking and burst-firing cells in addition had basketlike terminals

107 etitive-firing, repetitive/burst and initial-burst-firing cells were reduced to a single-spiking patt

108 ms in regular-spiking and 99.7 +/- 42 ms in burst-firing cells.

109 lation, but, while causing some increases in burst firing, cells continued to produce tonic spikes ev

110 ngle action potentials continuously, whereas burst firing consists of grouped discharges separated by

111 their intrinsic ability to generate rhythmic burst firing, contributes to the development of sensory

112 l cord raises the possibility that intrinsic burst firing could provide an endogenous drive to the de

113 s using action potential waveforms show that burst firing depends on small net inward currents that f

114 Although burst firing depends on the net balance between multiple

115 ular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization.

116 ing during increased neocortical arousal and burst firing during decreased neocortical arousal.

117 of the rat spinal cord exhibits oscillatory burst firing during early life, which occurs independent

118 cortical outflow neurons of their patterned burst firing during singing, without changing their spon

119 ionic conductances that underlie all-or-none burst firing elicited in acutely dissociated mouse Purki

120 ACC than PFC, and (iii) hosted neurons with burst firing events that synchronized to distant gamma a

121 AHPs triggered with theta-burst firing every 30 s were progressively reduced, wher

122 G betagamma subunits play a dominant role in burst firing evoked by applied OT or by suckling.

123 However, the tonic firing pattern changed to burst firing exclusively during PTC, and this vlPAG neur

124 burst amplitudes (the number of spikes in a burst), firing frequency within bursts or peak firing ra

125 hat cocaine increases both the pacemaker and burst-firing frequency of rat ventral-midbrain dopaminer

126 together, our data suggest that epileptiform burst firing generated in the CA3 region by activity-dep

127 Burst firing has been implicated in enhancing reliabilit

128 Burst firing has been reported as a pathological activit

129 A synaptically generated form of burst firing has been shown to arise from complex excita

130 th an intrinsic ability to generate rhythmic burst-firing have been characterized in lamina I of the

131 lude that OT neurons in males are capable of burst firing highly similar to that seen in lactating ra

132 g DA neurons); mean firing rate; and percent burst firing (i.e., the proportion of action potentials

133 ated acoustically evoked neuronal firing and burst firing, immediately preceding TE, have been observ

134 nd that DA and D2 receptor agonists promoted burst firing in a subset of pyramidal cells, which was r

135 ntly, Ba(2)(+) application unmasked rhythmic burst firing in approximately 42% of nonbursting lamina

136 underlying the expression of high frequency burst firing in awake conditions, I(Twindow) is of criti

137 excitatory synapses but nevertheless induced burst firing in both Fmr1(-/y) and peptide-treated WT sl

138 Because the ADP correlates directly with burst firing in CA1 neurons, R-type calcium channels are

139 n the generation of spontaneous epileptiform burst firing in cornu ammonis (CA) 3 pyramidal neurons i

140 tability manifested as a lower threshold for burst firing in diabetic than in control cells.

141 Both apamin and NMDA evoke burst firing in dopamine neurons recorded intracellularl

142 type calcium channels that are important for burst firing in GnRH neurons.

143 important role for dendritic conductances in burst firing in intact Purkinje neurons.

144 r understanding of the mechanisms underlying burst firing in midbrain dopaminergic neurons and those

145 g OT concentrations from 1 to 100 pm induced burst firing in OT neurons in patch-clamp recordings.

146 We explored mechanisms underlying burst firing in oxytocin (OT) neurons in the supraoptic

147 g-term depression resulting from coordinated burst firing in pairs of coupled TRN neurons.

148 putative generator of pathological rhythmic burst firing in Parkinson's disease (PD).

149 5%) induced delayed after depolarization and burst firing in PVs, but not in LA.

150 Purkinje neurons often generate all-or-none burst firing in response to depolarizing stimuli.

151 The EPSCs are multipeaked, owing to burst firing in several olivary afferents that fire asyn

152 re, 5-HT and CP93129 inhibited STN-triggered burst firing in SNr GABA neurons, and CP93129's inhibito

153 the excitatory STN-->SNr projection, reduces burst firing in SNr GABA neurons, and thus may play a cr

154 ncreased the STN-triggered complex EPSCs and burst firing in SNr GABA neurons, demonstrating the effe

155 ctivation of TRPM2 channels is necessary for burst firing in SNr GABAergic neurons and their responsi

156 tonomous, rhythmic, single-spike activity to burst firing in STN neurons.

157 activity, may contribute to the emergence of burst firing in STN.

158 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo.

159 ls, alpha(1g) is most likely responsible for burst firing in thalamic relay cells.

160 properties of pulvinar neurons that promote burst firing in the adult may be relevant to the treatme

161 spontaneous regular firing, but also exhibit burst firing in the presence of NMDA or when excitatory

162 ts are involved in generating high frequency burst firing in the subiculum, but the exact nature of t

163 One of the mechanisms underlying burst firing in these cells is the afterdepolarization (

164 d Ca(2+) spikes that directly correlate with burst firing in these neurons, differential redox regula

165 ritic Ca(2+) increases and the generation of burst firing in TRN neurons.

166 us (LDTg) is required for glutamate-elicited burst firing in ventral tegmental area DA neurons of ane

167 Burst firing in vitro is eliminated after blockade of IC

168 r activation promotes a switch from tonic to burst firing in vitro.

169 However, what afferents are requisite for burst firing in vivo is not known.

170 ng that was similar in frequency and form to burst firing in vivo, (2) the efficacy of glutamatergic

171 rom food-restricted mice exhibited increased burst firing in vivo, an effect that was enhanced by an

172 m Homers enhanced mGluR-induced epileptiform burst firing in wild-type (WT) animals, replicating the

173 e that FFA reduces repetitive- and abolishes burst-firing in CA1 pyramidal neurons.

174 abies virus PRV-152 revealed the presence of burst-firing in PRV-infected lamina I neurons, thereby c

175 pendent low-threshold-Ca2+ spikes as well as burst-firing in reticular thalamic neurons at physiologi

176 Similar results were observed with burst-firing in ventral but not dorsal putamen, indicati

177 te Cav3.1-containing T-channels in subicular burst firing, in contrast to several previous reports di

178 ell recordings using KGluc, repetitive theta-burst firing induced AHP plasticity that mimics learning

179 au potential that underlies the epileptiform burst firing induced by metabotropic glutamate receptor

180 Burst firing induced MEF2A/D-dependent induction of the

181 Burst firing induces a large transient increase in synap

182 tems that modulate dopamine system function: burst firing induces massive synaptic dopamine release,

183 nt injection and were grouped as follows: 1) burst-firing interneurons (n = 13), 2) regular-firing in

184 t in brain slices and converted pathological burst firing into physiological tonic, single-spike firi

185 Burst firing is a hallmark of neuroplastic changes known

186 Notably, an increase in burst firing is also seen in Parkinson's disease.

187 dels of epilepsy have shown that synchronous burst firing is associated with epileptogenesis, yet the

188 hypothalamic oxytocin (OT) neurons in vivo, burst firing is associated with pulsatile secretion of O

189 In CA1 pyramidal neurons, burst firing is correlated with hippocampally dependent

190 DA neuron burst firing is dynamically regulated by afferent inputs

191 asic inhibition generated in response to nRT burst firing is greatly reduced in alpha4(0/0) pairs, su

192 During slow-wave sleep, rhythmic burst firing is prominent, whereas during waking or rapi

193 mmunication) stimuli is uncompromised, while burst firing is reduced.

194 Given this, burst firing is surprisingly robust in the face of chang

195 In particular, stimulus-dependent burst firing may carry additional information that isola

196 olarizing actions of GABA and GABA-dependent burst-firing may synchronize a rapid release of GABA, NP

197 ealed the capability for autorhythmicity and burst firing, mediated by a T-type Ca(2+) conductance.

198 o switch from repetitive single spiking to a burst-firing mode by constant depolarizing current injec

199 thus enhance the probability to switch into burst-firing mode, which then potentiates GIRK currents

200 transition of dopamine neurons from tonic to burst firing modes.

201 ive to sleep loss, switching from spiking to burst-firing modes.

202 ations was of a single spiking rather than a bursting firing nature, and was coherent with extracellu

203 rophysiological types, except for the type I burst-firing neuron, had a main axon that coursed toward

204 el finding was the existence of two types of burst-firing neuron.

205 Burst firing neurons (n=8) generally had triangular soma

206 trast to continuous firing neurons, 14 of 19 burst firing neurons and 3 of 7 intermittent firing neur

207 ns, four were slow firing neurons, five were burst firing neurons and nine were fast firing neurons.

208 Burst firing neurons generated bursts of APs (n=19).

209 regular firing neurons, while presynaptic in burst firing neurons.

210 Type I burst-firing neurons had significantly longer duration a

211 n collaterals of the fast-spiking and type I burst-firing neurons was more extensive than that of the

212 w-firing, fast-spiking, regular-spiking, and burst-firing neurons; previous work has suggested that t

213 The natural burst firing observed in vivo in mesolimbic dopamine neu

214 Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor.

215 are the manifestation of highly synchronized burst firing of a large population of cortical neurons.

216 Excessive burst firing of action potentials in subthalamic nucleus

217 dings suggest that persistent high-frequency burst firing of cerebellar neurons caused by sodium pump

218 into the vSub decreased the firing rate and burst firing of DA neurons without altering the number o

219 f these neurons during experimentally evoked burst firing of DAergic axons that reproduce the reward-

220 triction also enhanced aspartic acid-induced burst firing of dopamine neurons in an ex vivo brain sli

221 chronic mild food restriction increases the burst firing of dopamine neurons in the substantia nigra

222 diated transmission, amphetamine may promote burst firing of dopamine neurons.

223 NMDA receptors regulate burst firing of dopaminergic neurones in the substantia

224 Our results support the hypothesis that burst firing of ET cells triggers the release of endocan

225 was associated with a strong increase in the burst firing of GABAergic perigeniculate neurons.

226 ental models of Parkinson's disease promotes burst firing of neurons in the subthalamic nucleus (STN)

227 in a manner that would also lead to enhanced burst firing of neurons.

228 uited in a phasic manner specifically during burst firing of nRT cells and provide sufficient GABA-AR

229 ium channel that modulates glutamate-induced burst firing of nucleus accumbens neurons.

230 s found for Ih in modulating the spontaneous burst firing of RP3V kisspeptin neurons.

231 ion of local estrogen levels rapidly changes burst firing of single auditory neurons.

232 Moreover, excessive burst firing of SNR neurons seen in Parkinson's disease

233 Here we report that rebound burst firing of STN neurons induces long-lasting bidirec

234 Burst firing of STN neurons may be driven by rebound dep

235 Burst firing of substantia nigra dopamine (SN DA) neuron

236 n regulating spike patterning indicates that burst firing of TANs in vivo could arise from direct or

237 logical classification of cells as intrinsic burst firing or regular spiking neurons was correlated w

238 tonic firing intensifies synaptically driven burst firing output in dopamine neurons.

239 ad Ca2+ influx, large after-depolarizations, burst firing output, and long-term potentiation of perfo

240 ow-voltage-activated T-type channels mediate burst firing, particularly in thalamic neurons.

241 Neurons that were in a burst firing pattern immediately before stimulation assu

242 The calyx showed a characteristic burst firing pattern, which has previously been shown to

243 bradykinesia is causatively regulated by the burst-firing pattern of the subthalamic nucleus (STN) in

244 eurones with broader spikes and adapting and burst firing patterns activated the broadest IPSPs and r

245 However, burst firing patterns in both nuclei in the slow-wave ac

246 with this finding, both regular-spiking and burst firing patterns were profoundly depressed in the m

247 of MNCs and are necessary for characteristic burst firing patterns which serve to maximize hormone re

248 opamine (DA) neurons to switch from tonic to burst firing patterns.

249 le neuropeptide secretion is associated with burst firing patterns; however, intracellular signaling

250 "bursty" cells were observed that exhibited burst-firing patterns similar to normal HD cells but wit

251 al-by-trial variations in mean spike rate or burst-firing patterns, and potentially provides a princi

252 type calcium currents, and tonic- or initial bursting firing patterns, and received weak excitatory s

253 Enhanced burst firing persisted after 10 d of free feeding follow

254 Burst firing persisted in concentrations of tetrodotoxin

255 o, both the firing rate (tonic activity) and burst firing (phasic activity) of identified midbrain DA

256 plasticity that persistently eliminates the burst firing potential of Re neurons.

257 We further demonstrate that BF burst firing predicted successful detection of near-thre

258 lasticity that eliminates the high-frequency burst firing present in many Re neurons.

259 xcitability (after-polarization duration and burst firing probability were increased in KO).

260 s of a cannabinoid agonist known to increase burst firing produce ongoing fluctuations in extracellul

261 EX-BKCa mRNAs induced similar changes in the burst firing properties of hippocampal neurons.

262 channels influence neurotransmitter release, burst firing rate activity, pacing, and critical dampeni

263 Signal-independent noise and pre-burst firing rates were reduced with practice.

264 esent a seizure-like state in which neuronal burst firing renders animals unresponsive to incoming ta

265 Rather, enhancement of burst firing required synergistic activation of group I,

266 g thalamic relay cells and promoting rebound burst firing responses.

267 nce in vivo, was arranged such that thalamic burst firing resulted in stimulation of the corticothala

268 In turn, GABA-evoked burst firing results in delayed and long-lasting feedfor

269 ave intrinsic membrane properties that favor burst firing, seen not only during complex spikes elicit

270 sodium channel (Na(V)beta4) associated with burst firing showed increased mRNA production.

271 e saccades, however, the duration of agonist burst firing significantly affects the control of saccad

272 aking of these neurons, resulting in erratic burst firing similar to that identified in vivo.

273 onto 7/7 oriens-lacunosum moleculare and 5/5 burst firing, sparsely spiny neocortical interneurones d

274 the coupling was strong; they could modulate burst-firing states even when the coupling strength was

275 formed by CA1-region pyramidal neurons onto burst-firing subiculum neurons, presynaptic in vivo knoc

276 s consistent with widespread thalamocortical burst firing such as increased delta oscillations (1-4 H

277 st in characterizing mechanisms that promote burst firing, such as the regulation of NMDA receptor fu

278 neuronal firing and the change from tonic to burst firing suggest that AGS kindling involves increase

279 postsynaptic activity, in the form of theta-burst firing (TBF) of hippocampal CA1 pyramidal neurons,

280 ng autonomous activity or generating rebound burst firing than control transmission.

281 lex EPSCs may contribute to the pathological burst firing that is associated with the symptoms of Par

282 scillations are driven by an unusual form of burst firing that is present in a subset of thalamocorti

283 channels, promoting rhythmic high-frequency burst firing that reduces sensory information transfer.

284 levels of tonic firing were found mixed with burst firing throughout the recordings even under condit

285 se that ICAN is selectively activated during burst firing to boost NMDA currents and allow plateau po

286 human studies linking neuronal synchrony and burst firing to epileptogenesis remains equivocal.

287 ion pattern of action potentials from phasic burst firing to regular tonic firing, hypothetically red

288 ed to a stimulus, this causes an increase in burst firing to the attended stimulus.

289 ive pharmacological inactivation of dopamine burst firing using the NMDA receptor antagonist, AP-5.

290 Driving GnRH neurons to exhibit simultaneous burst firing was ineffective at altering LH secretion.

291 This burst firing was suppressed by a cannabinoid receptor an

292 ent with the established role of I(h) in ETC burst firing, we show that endogenous DA release increas

293 m feedback mechanisms that serve to maintain burst firing when voltage-dependent sodium conductance i

294 dynamic to prevent the prolonged periods of burst firing which can be evoked in brain slice preparat

295 ic rats reveal an age-dependent reduction in burst firing, which likely results in further reductions

296 e mitral cells commonly respond to odours by burst firing with each inhalation cycle, we used bursts

297 acological inhibition of T-channels switched burst firing with lower depolarizing stimuli to regular

298 the two subtypes play a unique function with burst firing, with a somewhat more prominent and possibl

299 In addition, the prevalence of spontaneous burst firing within lamina I was enhanced in the presenc

300 M interneuron silencing powerfully increased burst firing without altering the theta phase of spikes.