ライフサイエンスコーパス: butenolide

1 bstituents render the exclusive formation of butenolides.

2 rt synthesis of the homochiral disubstituted butenolide 1 is described in four steps from arabitol.

3 esulted in a homoaldol condensation yielding butenolide (22).

4 n of the selenoxide derived from tetracyclic butenolide 50 to give (-)-norsecurinine (6).

5 Butenolides 5a and 13 were used as optically active temp

6 Butenolide amide, the major product from the fragmentati

7 yclization/fragmentation cascade that unites butenolide and trans-hydrindane fragments while fashioni

8 Diastereoselectivity was observed and gamma-butenolides and gamma-butyrolactams showed opposite dias

9 ium hydroxide-induced fragmentation provides butenolides and gamma-hydroxycyclohexenones.

10 rt a Zn-ProPhenol catalyzed reaction between butenolides and imines to obtain tetrasubstituted vinylo

11 rotocol enabled the synthesis of substituted butenolides and isocoumarins from allyl esters.

12 n to a complex cyclohexanone 83 appended the butenolide, and a few additional steps provided (-)-gymn

13 nthesis of gamma-amino acids from beta,gamma-butenolides by an in situ esterification, condensation,

14 Notably, both alpha,beta- and beta,gamma-butenolides can be utilized as nucleophiles in this tran

15 ps including double bond stereochemistry and butenolide configuration.

16 powerful tool for the rapid construction of butenolide-containing natural products.

17 at AtD14 and KAI2 exhibit selectivity to the butenolide D ring in the 2'R and 2'S configurations, res

18 structurally diverse A-ring moieties to the butenolide D-ring.

19 t led to the discovery of a potent series of butenolide ETA selective antagonists.

20 -ray crystallographic analysis of the closed butenolide form of PD156707 shows the benzylic group loc

21 d a gamma-hydroxy propiolate as a handle for butenolide formation via Ru-catalyzed alkene-alkyne coup

22 -promoted fragmentation reactions to provide butenolides, gamma-butyrolactone, and/or beta,gamma-epox

23 e-induced fragmentation reactions to provide butenolides, gamma-hydroxycyclohexenones, and/or gamma-b

24 pendent secondary metabolites, including T39 butenolide, harzianolide, and sorbicillinol.

25 nagel aldol adducts, gamma-substituted gamma-butenolides, has been explored.

26 We report its synthesis in six steps from a butenolide heterodimer via its likely biosynthetic precu

27 The carbonyl group in butenolide holds the position of thiophenyl moiety in re

28 the preparation of a variety of substituted butenolides in a simple and efficient way.

29 ess to synthetically important 3-substituted butenolides in enantioenriched form.

30 -butyrolactones along with a small amount of butenolides in limited cases.

31 enantiomerically pure spirocyclic alpha,beta-butenolides is presented where the fundamental framework

32 ta,delta-elimination form cross-links to the butenolide lesion (4).

33 ddition, approaches to install the requisite butenolide moiety at the C17 position are discussed.

34 rikins and strigolactones are two classes of butenolide molecules that have diverse effects on plant

35 enzothiazolylidene donor and three different butenolide nitriles have been synthesized and characteri

36 other nucleophiles to give the corresponding butenolides, nitro compounds, and alpha-substituted tetr

37 The cis-dihydroxylation of a variety of butenolides occurred with the major product formed from

38 a variety of building blocks bearing a gamma-butenolide or gamma-lactone connected to a cycloalkane o

39 s with arene diazonium salts to alpha-benzyl butenolides or pentenolides, respectively, or to alpha-b

40 Derivatives of the proaromatic butenolide PhFu show the best nonlinearities.

41 three components, two mono-THF alkenes and a butenolide precursor, and the olefin cross-metathesis an

42 ccess the target by dimerization of a simple butenolide precursor.

43 4-(2'-Naphthoxy)-2-butenolide, readily available with high enantiopurity by

44 nzylic group located on the same side of the butenolide ring as the gamma-hydroxyl and the remaining

45 l and the remaining two phenyl groups on the butenolide ring essentially orthogonal to the butenolide

46 Further structural modifications around the butenolide ring led directly to the subnanomolar ETA sel

47 abitol and the cyclization of 11 to form the butenolide ring.

48 utenolide ring essentially orthogonal to the butenolide ring.

49 rigolactones and smoke-derived karrikins are butenolide signals that control distinct aspects of plan

50 e SMXL family enabled responses to different butenolide signals through a shared regulatory mechanism

51 eceptor for karrikins, germination-promoting butenolide small molecules found in the smoke of burned

52 The butenolide termini are attached to the ACD, BCE, or BCD

53 The butenolide termini segments were prepared from (S)- or (

54 nus, A or B, a spacer subunit, D or E, and a butenolide terminus, F or G.

55 segments are coupled to a C4- or C5-hydroxy butenolide terminus.

56 ening of a terminal epoxy ring tethered to a butenolide to produce stereoselectively a five-membered

57 Michael reactions of beta, gamma-unsaturated butenolides to alpha, beta-unsaturated ketones.

58 The butenolides were reduced and acylated in situ to give ac

59 ormed carbenoid onto the alkyne to produce a butenolide which then undergoes C-H insertion into the n