ライフサイエンスコーパス: butyrolactone

1 ounterparts, gamma-hydroxybutyrate and gamma-butyrolactone.

2 7, was blocked by a Cdk5-specific inhibitor, butyrolactone.

3 c intermediate ultimately derived from gamma-butyrolactone.

4 to a variety of biologically important gamma-butyrolactones.

5 y streptomycetes produce extracellular gamma-butyrolactones.

6 gh proportion of (E)-alpha-benzylidene-gamma-butyrolactones.

7 trifluoromethylated cis-fused bicyclic gamma-butyrolactones.

8 p synthesis of two naturally occurring gamma-butyrolactones.

9 h methyl-substituted olefinic azlactones and butyrolactones.

10 r methyl-substituted olefinic azlactones and butyrolactones.

11 l migrations delivering bridged, spiro-gamma-butyrolactones.

12 clization reactions to provide hydroxy-gamma-butyrolactones.

13 screened in the context of generating gamma-butyrolactones.

14 s, gamma-hydroxycyclohexenones, and/or gamma-butyrolactones.

15 ine, ephedrine, gamma-hydroxybutyrate; gamma-butyrolactone, 1,4-butanediol, flunitrazepam, ketamine,

16 multigram scales beginning with inexpensive butyrolactone (10).

17 21 (10%) used gamma-hydroxybutyrate or gamma-butyrolactone, 175 (8%) used methamphetamine, and 162 (7

18 e, diketene (4-methyleneoxetan-2-one), gamma-butyrolactone, 2(5H)-furanone, and delta-valerolactone.

19 e, diketene (4-methyleneoxetan-2-one), gamma-butyrolactone, 2(5H)-furanone, and delta-valerolactone.

20 coelicolor A3(2) and S. griseus: (1) gamma -butyrolactones; (2) a complex cascade of mostly undefine

21 ched 5-substituted alpha-exo-methylene gamma-butyrolactones 3a-i.

22 , 1j, and 1l forms alpha-exo-methylene-gamma-butyrolactones 5b, 5f, 5j, and 5l in moderate to good yi

23 the disubstituted alpha-exo-methylene gamma-butyrolactones 6a and 6b with good to excellent levels o

24 sformed to the trans-4,5-disubstituted gamma-butyrolactones 7a, 7l, and 7p.

25 required for A-factor synthesis of the gamma-butyrolactone A-factor and consequently for streptomycin

26 ghly stereoselective one-pot approach to the butyrolactone, a challenging sp(2)-sp(3) Suzuki coupling

27 pyl carbinols to form alpha-alkylidene-gamma-butyrolactones (ABLs) is reported.

28 trasts with other reports that loss of gamma-butyrolactones abolishes antibiotic production.

29 (TGM/DBA) or without (TGM) a dimethyl-gamma-butyrolactone acrylate (DBA)-containing lactone ring tha

30 results in predominantly 5-substituted gamma-butyrolactones along with a small amount of butenolides

31 A variety of gamma-butyrolactone analogues also modulate GABA-induced curre

32 sis, and evaluation of alpha-methylene-gamma-butyrolactone analogues and their evaluation as anticanc

33 alpha-Methylene-gamma-butyrolactone and alpha-methylene-delta-valerolactone un

34 olved in the ring-opening reactions of gamma-butyrolactone and delta-valerolactone, the conformationa

35 Interestingly, 1-propanol, delta-butyrolactone and ethyl lactate concentrations, showed n

36 Novel 5-(1'-hydroxy)-gamma-butyrolactone and gamma-butyrolactam subunits were synth

37 Corroborating our previous results, butyrolactone and hexanoic acid, previously considered a

38 aldol addition of alpha,beta-dichloro gamma-butyrolactones and gamma-butyrolactams with aldehydes un

39 activated ketones and imines provides gamma-butyrolactones and lactams, respectively.

40 ion mutant of scbR also failed to make gamma-butyrolactones and showed delayed Red production.

41 lon-caprolactone, delta-butyrolactone, gamma-butyrolactone, and D, L, meso, and racemic lactides has

42 hat negatively regulates metabolism of gamma-butyrolactone, and its repressing function is relieved b

43 tion reactions to provide butenolides, gamma-butyrolactone, and/or beta,gamma-epoxycyclohexanones.

44 federal government, 1,4-butanediol and gamma-butyrolactone, another precursor of gamma-hydroxybutyrat

45 nantioenriched, densely functionalized gamma-butyrolactones are of high synthetic utility, as highlig

46 alpha-Alkylidene-gamma-butyrolactones are readily prepared by the palladium-cat

47 Polymerization of beta-butyrolactone (BBL) and beta-valerolactone (BVL) using t

48 Terpolymerizations of (rac)-beta-butyrolactone (BBL), cyclohexene oxide (CHO), and carbon

49 te, methyl formate, beta-propiolactone, beta-butyrolactone, beta-isovalerolactone, diketene (4-methyl

50 and methyl formate, beta-propiolactone, beta-butyrolactone, beta-isovalerolactone, diketene (4-methyl

51 versatile latent carbonyls from which gamma-butyrolactones, beta-hydroxy methyl ketones, and beta-hy

52 ranscribed gene, scbR, which encodes a gamma-butyrolactone binding protein.

53 genes, which are related to genes for gamma-butyrolactone-binding proteins.

54 tetrahydrofuran (THF) to exclusively afford butyrolactone (BTL), likely a result of prolonging the r

55 n of renewable alpha-methylene-gamma-(methyl)butyrolactones by chiral C(2)-symmetric zirconocene cata

56 ethod of preparing enantiopure hydroxy-gamma-butyrolactones containing multiple contiguous stereocent

57 - 2.4 kcal/mol for beta-propiolactone, gamma-butyrolactone, delta-valerolactone, and epsilon-caprolac

58 amates, as well as tetrahydrofuran and gamma-butyrolactone derivatives, without erosion of enantiomer

59 n and trapping the generated 17-radical with butyrolactone disulfides.

60 tonization to afford the corresponding gamma-butyrolactones, each as a single isomer.

61 raw and roasted defective seeds in general), butyrolactone (for raw defective seeds in general), and

62 y selective NHC-catalyzed synthesis of gamma-butyrolactones from the fusion of enals and alpha-ketoph

63 However, the bioderived five-membered gamma-butyrolactone (gamma-BL) is commonly referred as 'non-po

64 f the biorenewable "non-polymerizable" gamma-butyrolactone (gamma-BL) to a high-molecular-weight meta

65 ctones including epsilon-caprolactone, delta-butyrolactone, gamma-butyrolactone, and D, L, meso, and

66 gamma-butyrolactone (GBL) (750 mg/kg i.p.) increased DOPA leve

67 ese processes are under the control of gamma-butyrolactone (GBL) autoregulatory systems.

68 ronal impulse flow and DA release with gamma-butyrolactone (GBL) increased DA concentrations in the s

69 In the gamma-butyrolactone (GBL) model of DA autoreceptor function, m

70 abolition of DA neuronal activity [by gamma-butyrolactone (GBL) treatment or transection of the nigr

71 mide (DMF), dimethyl sulfoxide (DMSO), gamma-butyrolactone (GBL), and water.

72 with the nerve impulse flow inhibitor gamma-butyrolactone (GBL).

73 g a sulfur atom in the alpha-position of the butyrolactone group, whereas carbon-linked lactones were

74 3-Hydroxy-gamma-butyrolactone has been identified as one such chemical;

75 opropyl ring to access fused tricyclic gamma-butyrolactones has been described.

76 The stereochemistry of these hydroxy-gamma-butyrolactones has been established using NOE spectrosco

77 he application of the CDK inhibitors p21 and butyrolactone I but not p16.

78 Butyrolactone I, a cdk5 inhibitor, had an additional pro

79 from culture fluids, but differed from gamma-butyrolactones in being alkali resistant.

80 ence of an organocatalyst yields trans-fused butyrolactones in high yield and enantioselectivities.

81 he need to isolate and purify the toxic beta-butyrolactone intermediate.

82 in-derived spirocyclic alpha-methylene-gamma-butyrolactone is a suitable core for optimization to ide

83 ivity were ethyl hexanoate, ethyl octanoate, butyrolactone, isoamyl alcohols, acetaldehyde, ethyl ace

84 of the cluster directs synthesis of a gamma-butyrolactone-like autoregulator.

85 The butyrolactones linked to the steroidal nucleus via the b

86 That putative gamma-butyrolactone material was not produced when orf18 * was

87 alpha-Methylene-gamma-butyrolactone (MBL), a naturally occurring and biomass-s

88 sults indicate a complex mechanism for gamma-butyrolactone-mediated regulation of antibiotic biosynth

89 renewable gamma-methyl-alpha-methylene-gamma-butyrolactone (MMBL).

90 solution of CH(3)NH(3)I and PbI(2) in gamma-butyrolactone on a 400 nm thick film of TiO(2) (anatase)

91 This enhancement was eliminated by either butyrolactone or CK1-7 and was absent in DARPP-32 knocko

92 The chemical synthesis of poly(gamma-butyrolactone) (PgammaBL) through the ROP process has be

93 s of a novel series of 17beta-glucocorticoid butyrolactones possessing either a 16alpha,17alpha-isopr

94 Additionally, they show that the gamma-butyrolactones probably interact at two different sites

95 ator in addition to being required for gamma-butyrolactone production.

96 Bromination of the methylene butyrolactone products followed by zinc-mediated reducti

97 of three further bld genes and several gamma-butyrolactone receptor genes have led to new ideas about

98 vidans, we showed that TylP, a deduced gamma-butyrolactone receptor, downregulated reporter gene expr

99 , similar to the targets for authentic gamma-butyrolactone receptors, in the promoters of tylP, tylQ

100 Peripherally, C75, an alpha-methylene-gamma-butyrolactone, reduces adipose tissue and fatty liver, d

101 Gamma-butyrolactones regulate secondary metabolism and, someti

102 treptomyces homologue CprB, which is a gamma-butyrolactone regulator.

103 nalogous functions to the better known gamma-butyrolactone regulatory molecules.

104 phenylbutyraldehyde, and alpha-hydroxy-gamma-butyrolactone, relying on cyanoborohydride for coupling

105 nd 3,4-dihydroxybutyric acid+3-hydroxy-gamma-butyrolactone, respectively, molecules with potential us

106 as the stereoselective attachment of a gamma-butyrolactone ring to a tetracycle core structure by use

107 bond and a highly stable five-membered gamma-butyrolactone ring.

108 Addition of the gamma-butyrolactone SCB1 of S. coelicolor resulted in loss of

109 s and in the synthesis of a diffusible gamma-butyrolactone, SCB1, that can elicit precocious Act and

110 ne-gamma-butyrolactone to alpha-methyl-gamma-butyrolactone, Sharpless kinetic resolution, Sharpless a

111 e that the lack of polymerizability of gamma-butyrolactone should be attributed to the low strain of

112 ma factors, antibiotic biosynthesis, a gamma-butyrolactone signalling system, members of the actinomy

113 These led to a revised gamma-butyrolactone structure for the metabolite.

114 d (N55) with a new N-linoleoyl-2-amino-gamma-butyrolactone structure was purified from fenugreek seed

115 ted toward elaboration of the characteristic butyrolactone substituent.

116 es for the respective gene products in gamma-butyrolactone synthesis.

117 one (template I) and 4,4-disubstituted gamma-butyrolactone (template II), with the latter producing p

118 lective hydrogenation of exo-methylene-gamma-butyrolactone to alpha-methyl-gamma-butyrolactone, Sharp

119 light-mediated cyclization of an O-arylated butyrolactone to form a tricyclic cis-fused benzofuran a

120 tK, AttL, and AttM collectively covert gamma-butyrolactone to succinate.

121 These gamma-butyrolactones underwent intramolecular radical cyclizat

122 gamma-Butyrolactone, unlike delta-valerolactone, does not poly

123 ribes an enantioselective synthesis of gamma-butyrolactones, using the N-tolyl-substituted oxazolidin

124 nthetic strategy to cis-fused bicyclic gamma-butyrolactones via the retro-Diels-Alder reaction/intram

125 d for the stereoselective synthesis of gamma-butyrolactones via the sequence of N-acylation, C(alpha)

126 the diethyl phosphonate derivative of gamma-butyrolactone was treated with potassium hexamethyldisil

127 or homoalkynyl-alpha,beta-unsaturated gamma-butyrolactones was found to accelerate the rate of the i

128 l-2-ene (C(5)-1), the enol tautomer of gamma-butyrolactone, was generated in the gas phase as the fir

129 The glucocorticoid butyrolactones were hydrolyzed in human plasma by the en

130 ive the corresponding tetracyclic cage gamma-butyrolactones, which were employed as precursors for th

131 e reaction of optically pure 3-hydroxy-gamma-butyrolactone with a primary amine to give an amide, whi

132 to racemic alpha-keto esters, forming gamma-butyrolactones with three contiguous stereocenters.

133 A scbA mutant produced no gamma-butyrolactones, yet overproduced two antibiotics, actino