ライフサイエンスコーパス: butyrophilin

1 Butyrophilin 1A1 (BTN1A1) and xanthine oxidoreductase (X

2 Butyrophilin 1a1 (Btn1a1), which is a member of the Ig s

3 ound that the human and mouse genes encoding butyrophilin-2A2 (BTN2A2) are regulated by the class II

4 We find that a mAb specific for butyrophilin 3 (BTN3)/CD277 Ig superfamily proteins mimi

5 d or TCR Ab and blocked by Src inhibition or butyrophilin 3 isoform A1 (BTN3A1) disruption.

6 Evidence pointing to a role for the CD277/butyrophilin-3 (BTN3A) molecules in this response led us

7 Human Vgamma9Vdelta2 T cells recognize in a butyrophilin 3A/CD277-dependent way microbial (E)-4-hydr

8 Butyrophilin 3A1 (BTN3A1) binds small phosphorus-contain

9 g of pAg via the intracellular domain of the butyrophilin 3A1 (BTN3A1) molecule.

10 activation of Vgamma9Vdelta2 T cells is the butyrophilin 3A1 (BTN3A1) protein that contains an intra

11 The butyrophilin 3A1 intracellular domain undergoes a confor

12 2 T cell Ag-presenting transmembrane protein butyrophilin 3A1, providing information on critical resi

13 Butyrophilin, a membrane protein known to bind to XOR, w

14 t a negatively cooperative model of cellular butyrophilin activation.

15 mology to the carboxyl-terminal sequences of butyrophilin and an additional group of zinc finger gene

16 th other milk fat globule proteins including butyrophilin (Btn) and adipophilin (ADPH).

17 Butyrophilin (BTN) genes encode a set of related protein

18 The Ig superfamily protein butyrophilin (BTN)3A1 was shown to be required for preny

19 cell PAg levels are specifically detected by butyrophilin (BTN)3A1, using its intracellular B30.2 dom

20 The MHC-encoded butyrophilin, BTN2A1, is a cell surface glycoprotein rel

21 The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3

22 Butyrophilins (Btns) and butyrophilin-like (Btnl) molecu

23 activation by intact iRBCs is independent of butyrophilin expression by the iRBC, and contact with an

24 way, on Vgamma9Vdelta2 TCR signaling, and on butyrophilin expression by Vgamma9Vdelta2 T cells.

25 Several members of the butyrophilin family and the RoRet gene share an exon of

26 mily molecules; however, the function of the butyrophilin family in the immune system has not been de

27 programmed death 1 ligand 2 (PD-L2), and the butyrophilin family member butyrophilin-like 2 (BTNL2) w

28 Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costi

29 we characterize an MHC class II gene-linked butyrophilin family member, butyrophilin-like 2 (BTNL2),

30 flammation, and inhibitory members of the B7/butyrophilin family of ligands have evolved to balance t

31 The butyrophilin family of proteins shares sequence and stru

32 BTNL2 is thus the first member of the butyrophilin family that regulates T cell activation, wh

33 d mouse Skint1 and Btnl2, all members of the butyrophilin family, show greater structural and functio

34 The single BTN1A1 (butyrophilin) gene was positioned approximately 25 kb ce

35 es in mouse, with greatest similarity to the butyrophilin genes.

36 We investigated the expression of butyrophilin in eukaryotic cells with a view to determin

37 We found no evidence for soluble forms of butyrophilin in postmicrosomal supernatants.

38 Butyrophilin is synthesized from a single sized mRNA in

39 , reveal structure-activity relationships of butyrophilin ligands, and support a negatively cooperati

40 The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene expressed specifically by

41 Butyrophilins (Btns) and butyrophilin-like (Btnl) molecules are emerging as novel

42 ltiple butyrophilin molecules and found that butyrophilin-like (BTNL)1 molecule functions to dampen T

43 Butyrophilin-like 2 (BTNL2) is a butyrophilin family mem

44 (PD-L2), and the butyrophilin family member butyrophilin-like 2 (BTNL2) were also increased.

45 s II gene-linked butyrophilin family member, butyrophilin-like 2 (BTNL2), the mutation of which has b

46 family of immune regulator genes, including butyrophilin-like 2 (BTNL2; OMIM, 606000), which is asso

47 r milk lipid secretion in lactation, whereas butyrophilin-like 2 is a coinhibitor of T cell activatio

48 Butyrophilin-like 2 is expressed in patients with UM and

49 Main Outcomes and Measures: Butyrophilin-like 2 single-nucleotide variants were asso

50 Butyrophilin-like 2 variants showed highly variable freq

51 Conclusions and Relevance: Butyrophilin-like 2, expressed at various levels by UM c

52 An E2A target gene, the predicted butyrophilin-like gene NG9 (BTL-II), was also identified

53 1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, whi

54 of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin

55 the diversification of its beta-defensin and butyrophilin-like repertoires.

56 do not agree with previous suggestions that butyrophilin may exist in cytoplasmic soluble forms, or

57 lts are discussed with reference to the role butyrophilin may play as the principal scaffold for the

58 Some butyrophilins mediate complex interactions between antig

59 Unlike most other butyrophilin members, BTNL2 lacks the prototypical B30.2

60 er of the extended B7 superfamily related to butyrophilin, mimics PAg-induced Vgamma9Vdelta2 T-cell a

61 Butyrophilin molecules (commonly contracted to BTN), col

62 study, we performed an analysis on multiple butyrophilin molecules and found that butyrophilin-like

63 virus infection was assayed for lactadherin, butyrophilin, mucin, and secretory IgA.

64 between symptom status and concentrations of butyrophilin, mucin, or secretory IgA was found.

65 Although butyrophilin proteins share sequence homology with the B

66 The butyrophilin-related protein Btn2a2 was upregulated on m

67 e gene HLA-H, we identified a family of five butyrophilin-related sequences, two genes with structura

68 tiates transmembrane signaling and activates butyrophilin-responsive cells.

69 nd C-terminal domains were used to show that butyrophilin retains a type I topology in plasma membran

70 Evidence has recently emerged that butyrophilins, which are members of the extended B7 fami

71 a protein most closely related to mammalian butyrophilins, which are members of the immunoglobulin p