ライフサイエンスコーパス: butyryl-CoA

1 and Dh-FADH(-) that converts crotonyl-CoA to butyryl-CoA.

2 skeleton rearrangement of isobutyryl-CoA to butyryl-CoA.

3 h the priming of the enzyme by acetyl-CoA or butyryl-CoA.

4 ng acetyl-CoA approximately propionyl-CoA >> butyryl-CoA.

5 9-h lag in growth was observed, during which butyryl-CoA, a degradation product of ethylmalonyl-CoA,

6 Butyryl-CoA:acetate CoA-transferase activity was detecte

7 e, acetoacetyl coenzyme A (acetoacetyl-CoA), butyryl CoA, acetoacetate, and beta-hydroxybutyrate.

8 Priming DEBS with endogenous butyryl-CoA affords an alternative and more direct route

9 the interconversion of isobutyryl-CoA and n-butyryl-CoA also catalyzes the interconversion between i

10 ible interconversion of isobutyryl-CoA and n-butyryl-CoA and exists as a heterotetramer.

11 nthesis in S. collinus, which suggested that butyryl-CoA and isobutyryl-CoA function as starter units

12 Butyryl-CoA and isobutyryl-CoA interacted with the acety

13 The DEBS polyketide synthase (PKS) used butyryl-CoA and methylmalonyl-CoA supplied in vivo by th

14 oA dehydrogenase has maximal activity toward butyryl-CoA and negligible activity toward substrates lo

15 ylate via a novel pathway thought to involve butyryl-CoA and propionyl-CoA as intermediates.

16 f 2.4 microM for acetyl-CoA, 0.71 microM for butyryl-CoA, and 0.41 microM for isobutyryl-CoA.

17 We have shown that we can produce butyryl-CoA at levels of up to 50% of the total CoA pool

18 tical to those seen for MM-CoA; in addition, butyryl-CoA binds and behaves in a manner similar to pro

19 e biosynthesis and that either acetyl-CoA or butyryl-CoA can be a starter unit for palmitate biosynth

20 substrates of ZhuH, although acetyl-CoA and butyryl-CoA could also be accepted and elongated.

21 enzyme caused the midpoint potential for the butyryl-CoA/crotonyl-CoA couple (E(BCoA/CCoA)) to shift

22 en measured in the presence and absence of a butyryl-CoA/crotonyl-CoA mixture.

23 dies, the biosynthesis of the palmitate from butyryl-CoA decreases in the presence of thiolactomycin.

24 Electron-transferring flavoprotein (Etf) and butyryl-CoA dehydrogenase (Bcd) from Acidaminococcus fer

25 A (CoA) dehydrogenase (BHBD), crotonase, and butyryl-CoA dehydrogenase (BCD) from Clostridium acetobu

26 ectron transferring flavoprotein (EtfAf) and butyryl-CoA dehydrogenase (BcdAf) of Acidaminococcus fer

27 ween an acetyl-, propionyl-, isobutyryl-, or butyryl-CoA derived primer unit and a malonyl-CoA derive

28 M), which interconverts isobutyryl-CoA and n-butyryl-CoA; ethylmalonyl-CoA mutase, which interconvert

29 at CCR plays a significant role in providing butyryl-CoA for monensin A biosynthesis and is present i

30 reductase, which converts acetoacetyl-CoA to butyryl-CoA for use as a 4C extender unit during tylacto

31 tylicum are responsible for the formation of butyryl-CoA from acetoacetyl-CoA.

32 yme A (CoA) derivatives, such as acetyl-CoA, butyryl-CoA, HMG-CoA, and malonyl-CoA, as well as NADPH

33 n high concentrations of 4-hydroxy-4-phospho-butyryl-CoA in brain and liver.

34 catalyzes the conversion of crotonyl-CoA to butyryl-CoA in the presence of NADPH, was previously clo

35 EBS 1+TE can convert acetyl-, propionyl-, or butyryl-CoA into the corresponding C8-, C9-, and C10-lac

36 particular, its tolerance toward acetyl- and butyryl-CoA is unexpectedly strong.

37 talyze the condensation of malonyl-pfACP and butyryl-CoA (k(cat) 200 min(-1), K(M) 35.7 +/- 4.4 micro

38 substrate specificity and is able to accept butyryl-CoA, leading to the production of polyketides wi

39 he high concentration of 4-hydroxy-4-phospho-butyryl-CoA may be related to the cerebral dysfunction o

40 imple equation: crotonyl-CoA + NADH + H(+) = butyryl-CoA + NAD(+) with Km = 1.4 mum ferredoxin or 2.0

41 th the results using our standard substrates butyryl-CoA, octanoyl-CoA, and palmitoyl-CoA.

42 e inactivation upon incubation with either n-butyryl-CoA or isobutyryl-CoA.

43 tase, a primary metabolic enzyme involved in butyryl-CoA production in streptomycetes, was expressed

44 lysines correlated with the acetyl-CoA: (iso)butyryl-CoA ratio in liver.

45 ed as a transcriptional unit and form a BCS (butyryl-CoA synthesis) operon.

46 The butyryl-CoA synthesized was further extended to hexanoyl

47 mutant using butyryl-, crotonyl-, and 2-aza-butyryl-CoA thioesters.

48 nd R207Q) to catalyze the rearrangement of n-butyryl-CoA to isobutyryl-CoA.

49 e the exergonic reduction of crotonyl-CoA to butyryl-CoA to the endergonic reduction of ferredoxin bo

50 lmitate (a branched-chain fatty acid), while butyryl-CoA was converted to palmitate (a straight-chain

51 in 824(pAADB1) fermentations suggested that butyryl-CoA was limiting butanol production in 824(pAADB

52 ed with GroEL/ES, and the R147W variant when butyryl-CoA was used as a substrate.

53 inactivation when either isobutyryl-CoA or n-butyryl-CoA was used as substrate.

54 Optimal substrate (butyryl-CoA) was seen to shift the flavin redox potentia

55 f the loading didomain, although acetyl- and butyryl-CoA were also accepted with approximately 40-fol

56 the interconversion of isobutyryl-CoA and n-butyryl-CoA, whereas GTPase activity is associated with

57 ensation of two acetyl-CoA molecules to form butyryl-CoA, which is then transformed to succinyl-CoA w

58 t was unable to exchange the alpha-proton of butyryl-CoA with D(2)O.

59 ucial metabolic intermediates acetyl-CoA and butyryl-CoA with substantial velocities.