ライフサイエンスコーパス: by altering

1 r depression and other psychiatric disorders by altering a network of functionally related stress-sen

2 regulates class-switch recombination ex vivo by altering activation-induced cytidine deaminase expres

3 en successfully used for tissue regeneration by altering activity of various cells involved in period

4 such as hypoxia, can affect tumor behaviors by altering Akt activation, which has a critical role in

5 lling energy dissipation and defect dynamics by altering alloy complexity may pave the way for new de

6 fluences alpha-synuclein inclusion formation by altering alpha-synuclein levels.

7 Despite the ability to revamp axon outgrowth by altering an increasing number of extracellular and in

8 ple components of ILC2 metabolic programming by altering arginine catabolism, impairing polyamine bio

9 nknown effects on the central nervous system by altering astrocyte function.

10 deficiency causes primary autoimmune disease by altering B cell development, selection, and central t

11 cing early Ag-specific B cell expansion, not by altering B cell development.

12 , Elk1, Etf1 or Myb attenuated B cell action by altering B cell receptor pathways and MHCII cell surf

13 e medications may affect fetal drug exposure by altering BCRP expression in human placenta.

14 ood glucose and increase insulin sensitivity by altering bile acid signaling pathways.

15 upon entry to mitosis) to regulate function by altering biomolecular complex concentrations.

16 he hypothesis that ET-1 inhibits BK channels by altering BKalpha and beta1 surface trafficking in myo

17 ll membranes, halts liver cancer cell growth by altering both energy production and mammalian target

18 Transcriptional output can be modulated by altering burst fraction or burst size, but how regula

19 that regulate photoreceptor synaptic output by altering Ca(2+) channel activity.

20 selective pressure that promotes cell death by altering canonical signaling pathways.

21 the heart and contributes to QT prolongation by altering cardiac sodium current properties (INa).

22 17 function drastically reduces plant growth by altering cell division activity in both shoot and roo

23 roteins sensitizes M. tuberculosis to stress by altering cell wall integrity.

24 By altering cells' resting potentials using other ion tr

25 with binding to specific membrane lipids or by altering cellular structures such as membrane microdo

26 scription of thermogenic genes in adipocytes by altering chromatin accessibility and inhibiting ATF a

27 gesting that these lncRNAs promote induction by altering chromatin architecture.

28 ling enzymes that control gene accessibility by altering chromatin compaction or nucleosome positioni

29 suggests that CNVs may repress recombination by altering chromatin structure in meiosis.

30 and, as a result, activates gene expression by altering chromatin structure.

31 tions in PRSS1 cause hereditary pancreatitis by altering cleavage of regulatory nick sites by chymotr

32 ) of sudden changes in photosynthetic rates by altering CO2 concentration in plots subjected to +200

33 mate warming may affect biological invasions by altering competition between native and non-native sp

34 Our data suggest that, by altering cristae morphology, fusion in TM cells confi

35 igestion efficiency, which is not alleviated by altering denaturation/digestion stringency and indica

36 illars can manipulate attendant ant behavior by altering dopaminergic regulation and increasing partn

37 interactions influence protein folding rates by altering dynamics and not activation free energies.

38 tially diminishes several ecosystem services by altering ecosystem functioning and stability, especia

39 predispose an individual to type 2 diabetes by altering either hepatic or extrahepatic insulin actio

40 xpression directly regulates Na(+) transport by altering ENaC activity in the apical membrane.

41 WD1 modulates the BR signal transduction not by altering ER quality control or protein abundance of B

42 MSI2 influenced breast cancer cell growth by altering ESR1 function.

43 g to microtubules or the 3R:4R isoform ratio by altering exon 10 splicing.

44 ial chemoprevention may affect this response by altering exposure to malaria antigens.

45 association studies may exert their function by altering expression of eQTL genes (eg, LDLR and PCSK7

46 e adaptation to changing climatic conditions by altering expression.

47 he low-frequency state of a cortical circuit by altering extracellular glutamate, and therefore play

48 op-down attention increases coding abilities by altering firing rates and rate variability.

49 that dexamethasone may serve to enhance EXT by altering Fkbp5-mediated glucocorticoid sensitivity vi

50 By altering fluxes of heat, momentum, and moisture excha

51 that wind patterns impact incubation success by altering foraging movement.

52 ragmentation may intensify fires in Amazonia by altering forest microclimate and fuel dynamics.

53 ctivation of tumor suppressors, for example, by altering gene copy number amplitude.

54 shown that LKB1 suppresses tumor progression by altering gene expression in the tumor microenvironmen

55 ancer cells to platinum drugs, in large part by altering gene expression patterns related to DNA repa

56 hisms in modulating hepatic lipid deposition by altering gene transcription and controlling lipid com

57 nism of trade-off in resistance across drugs by altering genetic interactions.

58 sponds to deoxycholate, a component of bile, by altering global gene transcription in a manner consis

59 CD8(+) T cells abolish the resistance by altering glutathione and cystine metabolism in fibrob

60 reaction, such that damage can be inhibited by altering grain size and cation valence variability.

61 Plants sense temperature changes and respond by altering growth and metabolic activity to acclimate t

62 vivo and in vitro generates metabolic memory by altering H3K36me2 and H3K27me3 on the promoter of FOX

63 Livestock grazing can affect insects by altering habitat quality; however, the effects of gra

64 del in which FUT2 rs601338 influences holoHC by altering haptocorrin glycosylation, whereas B12 bound

65 rail health, outcomes potentially modifiable by altering health behaviors and/or treating endocrine a

66 shuttling growth factors to the nucleus and by altering histone acetylation in host cells.

67 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA

68 By altering host nutrient assimilation/excretion flexibi

69 rain injury may interrupt menstrual patterns by altering hypothalamic-pituitary-ovarian axis function

70 in non alcoholic fatty liver disease (NAFLD) by altering inflammatory signalling in RSF.

71 efenses directly as endophytes or indirectly by altering insect physiology.

72 lmitoylation, which enhance channel activity by altering interactions of the channel with the plasma

73 assium depolarizes the postsynaptic afferent by altering ion permeation through hyperpolarization-act

74 ion also depolarized the postsynaptic neuron by altering ion permeation through hyperpolarization-act

75 motherapeutic agent paclitaxel triggers CIPN by altering IP3 receptor phosphorylation and intracellul

76 This alginate-AuNPs THI system is tunable by altering its composition to suit different time-tempe

77 material for targeted delivery of probiotics by altering its digestion.

78 se decreases the lysosomal metabolism of APP by altering its endocytic vesicular transport.

79 intrinsic regenerative capacity of the host by altering its environment, whether with cell injection

80 role in regulating methionine concentrations by altering its flux through the transmethylation, trans

81 can be easily programmed to target new sites by altering its guide RNA sequence, and its development

82 lation of CDK5 repressed AKT phosphorylation by altering its intracellular localization, immediately

83 compensate for associated metabolic demands by altering its respiration rate.

84 the output period of the segmentation clock by altering its spatial pattern.

85 ritional and metabolic signals in the mother by altering its structural and functional phenotype, whi

86 poral scaling influence lifespan exclusively by altering kr.

87 ndent glucose flux decreases nutrient stress by altering lipid and amino acid metabolism in skeletal

88 ENaC abundance and function at least in part by altering luminal HCO3(-) and ATP concentrations.

89 l adaptations to hypobaric hypoxia, possibly by altering lung function.

90 ssion affects starch degradation indirectly, by altering matrix organization and, thus, accessibility

91 Conditioning the brain-dead organ donor by altering metabolism could be a novel approach to amel

92 t MYC mediates its oncogenic effects in part by altering mevalonate metabolism in glioma cells, sugge

93 n aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C,

94 uitment of monocytes to atherosclerotic foci by altering monocyte biophysics.

95 iate state can contribute to the onset of AD by altering multiple cellular pathways involved in ApoE-

96 roids modify the course of brain development by altering neurogenesis, cell death, migration, differe

97 l incontinence (FI) in women after menopause by altering neuromuscular continence mechanisms.

98 at has been shown to improve stroke recovery by altering neuronal activity of the target area.

99 esistance in cancer cells can be deregulated by altering NO homeostasis.

100 By altering nuclear size, we previously showed that the

101 VP40 SDP P85T interferes with VP40 function by altering octamer formation.

102 reduced silencing suppressor activity of p38 by altering one of two GW motifs that are required for p

103 reprogramming efficiency when overexpressed by altering OSK targeting, somatic-enhancer inactivation

104 kin infection contributes to immunopathology by altering peptidoglycan structure.

105 Thus, by altering pH, we showed that only non-ionised querceti

106 ce or manipulate insect behavior and fitness by altering plant quality and defense.

107 less severe Becker muscular dystrophy (BMD) by altering pre-mRNA splicing to restore an open reading

108 ding carbon storage capacity, in myriad ways by altering predation risk.

109 oncentration-dependent) effects on cognition by altering prefrontal cortical attractor dynamics accor

110 that PIs contribute to these adverse events by altering progesterone levels.

111 pecies, regardless of their charge, possibly by altering properties of the bacterial cell wall.

112 HIV-1 maturation can be impaired by altering protease (PR) activity, the structure of the

113 region of helices A/C/G/H/I and seems to act by altering protein dynamics rather than binding prefere

114 ffect protein structure and function, either by altering protein stability or interactions with its p

115 onstrate that JNK signaling is not perturbed by altering Pvr receptor tyrosine kinase activity.

116 triggers cardiomyopathy and premature death by altering regulation of sarco/endoplasmic reticulum ca

117 seases, not by driving initial symptoms, but by altering repair mechanisms.

118 g survival and reproduction, and indirectly, by altering resources.

119 latory elements that control gene expression by altering RNA structure upon the binding of specific m

120 oot length proliferation was mainly achieved by altering root architecture, but not root morphology.

121 to improve the acquisition of this nutrient by altering root development under shortage conditions.

122 NX1 activity either positively or negatively by altering RUNX1-mediated transcription, promoting prot

123 By altering S motifs in CLB19 and another editing factor

124 R enzymes that diversifies the transcriptome by altering selected nucleotides in RNA molecules.

125 henotype into that of non-CMS and vice versa by altering SENP1 levels.

126 raction between SMAD3 and vitamin D receptor by altering SMAD3 ubiquitination.

127 rtulacaceae) using two methods: in 2011-2013 by altering snow pack (snow-removal vs. control treatmen

128 y resistance could potentially be controlled by altering soil pH.

129 termite nests impart substrate heterogeneity by altering soil properties, thereby enhancing plant gro

130 ffect the assembly of ecological communities by altering species' spatial distribution patterns, but

131 By altering spectrotemporal characteristics of the maske

132 By altering surface biogeophysics, anthropogenic land us

133 ling that contributes to behavioral deficits by altering synaptic connections, and RhoA-ROCK inhibiti

134 may influence the function of remote organs by altering systemic cytokine levels.

135 hat induce an immune response against tumors by altering T-cell regulation have increased survival ti

136 l Ubiquitin-like Modifier (SUMO) binding and by altering TDG sumoylation through SUMO and SUMO protea

137 C proliferation and neuronal differentiation by altering TGF-beta signaling.

138 xin indoxyl sulfate can be modulated in vivo by altering the abundance of bacteria harboring tryptoph

139 ion of Hedgehog signaling leads to steatosis by altering the abundance of the transcription factors G

140 Attention is believed to enhance perception by altering the activity-level correlations between pair

141 shown to propagate down through the food web by altering the adaptive landscape for other species and

142 E3 regulates PDHc activity by altering the affinity of pyruvate dehydrogenase kinas

143 g site on the capsid protein (CP), and works by altering the angle between capsomers.

144 ependent and androgen-independent phenotypes by altering the AP-1/androgen receptor regulatory circui

145 crucial roles in gene expression regulation by altering the architecture of chromatin.

146 that neutrophils could regulate inflammation by altering the balance between PG-G and PG levels in vi

147 dulates spatial integration in visual cortex by altering the balance of inputs that generate neuronal

148 By altering the balance of tensions and pressures within

149 s and practices change the feedbacks in CASs by altering the behavior of different system components

150 By altering the beta-sheet peptide graft density and con

151 omain of decorin that controls muscle growth by altering the binding capacity for myostatin.

152 by divergence in cis-regulatory elements or by altering the binding specificity of transcription fac

153 living in contaminated coastal environments by altering the bioavailability and potentially toxicity

154 negatively contribute to disease progression by altering the bioavailability of molecules important t

155 in barrier; it affects susceptibility to HIT by altering the brain concentration of haloperidol.

156 acting with the receptor, and/or indirectly, by altering the bulk properties of the membrane.

157 affects the strength of cardiac contraction by altering the Ca(2+) transient as a response to physio

158 hicken embryos disrupted somite segmentation by altering the CDH2-dependent epithelialization of PSM

159 ated virus (AAV) to specific types of cells, by altering the cell-surface receptor it binds, is desir

160 asome inhibitor sensitivity of myeloma cells by altering the cellular proteasome capacity versus prot

161 nce tissue-specific differentiation of hESCs by altering the cellular response to morphogens.

162 (5)]enkephalin (DAMGO)-related glycopeptides by altering the charged residues of the amphipathic heli

163 nd outgassing can be detrimental to a system by altering the chemical and mechanical properties of ma

164 stability and function of cellular proteins by altering the chemical environment of the cell.

165 gh this point has traditionally been reached by altering the chemical structures of donors and accept

166 directly or indirectly regulate their influx by altering the chemotactic milieu in the islets.

167 Finally, by altering the chromatin state in the Arabidopsis chrom

168 ring the trafficking of the viral genome but by altering the chromatin subtype localization relative

169 By altering the community structure of the gut microbiom

170 h oil-enriched diets disfavor AA oxygenation by altering the composition of the FA pool in which PGHS

171 gger Streptomyces exploratory growth in part by altering the composition of the growth medium, and St

172 g strength, the cycle ratio can be regulated by altering the concentration of NaPy.

173 properties of these molecules can be changed by altering the configuration stereocenters within the b

174 gh direct interactions with the substrate or by altering the conformation of the residues surrounding

175 Further, they confer antiestrogen resistance by altering the conformational dynamics of the loop conn

176 Here, we provide evidence for this mechanism by altering the contractile activity of the tubular musc

177 modify the buoyant density of the particles by altering the copolymer ratio while maintaining their

178 g some that appear to affect gene expression by altering the copy number of intergenic regulatory reg

179 ent loading may destabilise these mutualisms by altering the costs and benefits each partner incurs f

180 the possibility of changing phonon dynamics by altering the crystal through acid etching.

181 Finally, we show that by altering the currents delivered to a set of immobile

182 ane (PFDMS) diblock copolymers can be varied by altering the degree of polymerization of PFDMS, and a

183 MH indirectly shape small-mammal habitat use by altering the density and distribution of understorey

184 this transformation occurs can be controlled by altering the design of individual units and the array

185 elf-assembly of DNA functionalized emulsions by altering the DNA grafted strands.

186 r a polypeptide conformation can be achieved by altering the donor-acceptor properties of side-chain

187 ct on treatment resistance could be tempered by altering the dosing schedule of systemic chemotherapy

188 y discriminate between live and dead targets by altering the duration of conjugation.

189 odulates the activity of the embedded kinase by altering the dynamics of a glycine-rich motif that is

190 of monocytes to inflamed endothelial surface by altering the dynamics of adhesion receptors.

191 f size exclusion but that of ion dehydration by altering the electric permittivity of water-filled ca

192 threshold for laser initiation was achieved by altering the electronic properties of the ligand scaf

193 ound to play crucial roles in catalyzing OER by altering the electronic structures of the adjacent ca

194 resentation of behaviorally relevant stimuli by altering the encoding properties of single receptive

195 gest a role for HIV in impairing TB immunity by altering the equilibrium of M. tuberculosis-specific

196 ave significant roles in cancer pathogenesis by altering the expression of key tumorigenic or tumor-s

197 blood flow (d-flow) induces atherosclerosis by altering the expression of mechanosensitive genes in

198 ese cell types promote cancer progression is by altering the expression of microRNAs (miRNAs), small

199 s-eQTLs regulate expression of distant genes by altering the expression of nearby genes (cis-eGenes).

200 , proliferation, and differentiation of OPCs by altering the expression of regulatory cytoplasmic and

201 s as part of protein complexes or indirectly by altering the expression or activities of some cellula

202 We show that miR-122 enhances HCV RNA levels by altering the fraction of HCV genomes available for RN

203 OFs) amenable to significant property tuning by altering the functional groups on the imidazolate lin

204 noncoding RNAs (lncRNAs) may reprogram cells by altering the gene expression pattern.

205 Furthermore, by altering the gene regulatory sequences on the Rubisco

206 ironment by regulating mRNA synthesis, often by altering the genomic sites at which RNA polymerase in

207 o tune the onset of the crumpling transition by altering the geometry and topology of the sheet itsel

208 eable and can be shifted to proximal regions by altering the growth temperature.

209 tentials of these copolymers were fine-tuned by altering the heterocycle sequence, and atomic force m

210 that target different regions of a sgRNA and by altering the hybridization free energy of the sgRNA-a

211 mpact on protein folding and oligomerization by altering the hydrogen bond network.

212 also affect the antigenicity of cancer cells by altering the immunopeptidome.

213 rate constants of the adaptive processes or by altering the initial number of rapidly but non-select

214 bacterial adaptation to nutrient deprivation by altering the initiation properties of RNA polymerase

215 diates the response to nutrient deficiencies by altering the initiation properties of RNAP.

216 LPFC rTMS affects punishment decision making by altering the integration of information about culpabi

217 tein facilitates exit from mitosis, possibly by altering the intracellular distribution of cyclin B1.

218 This can be done using drugs, by altering the ionic constituency of the bathing medium

219 Pathways could be switched by altering the ionic strength.

220 ermanium nanostructures can be tuned to 5.3% by altering the lattice constant of the matrix material,

221 mportant predator-prey interactions, in part by altering the location and size of spatial refugia for

222 nal synaptic plasticity in mice, most likely by altering the metabolism of BACE1 substrates.

223 ma in a range of 0.08-1.02 mN/m was achieved by altering the Mg(2+) concentration in solution, which

224 The mean length of the fibres can be varied by altering the micelle concentration, reaction stoichio

225 o the epidermal antibacterial defense system by altering the microbiome.

226 ing the primary target of a Th17 response or by altering the microbiota community structure.

227 By altering the mole ratio of sodium citrate/sodium algi

228 gnaling, but also improving cardiac function by altering the myofilament-Ca(2)(+) response via beta-a

229 rotein SynSerB3 rescues the deletion of serB by altering the natural regulation of the His operon.

230 El Tor biotype isolates gain CAMP resistance by altering the net charge of their cell surface through

231 en proposed to influence aggressive behavior by altering the neural processing of facial threat signa

232 at H19 induces a strong osteogenic phenotype by altering the NOTCH1 pathway.

233 the transcriptional activity of their genome by altering the nucleosome core particle through multipl

234 icts a stiffness optimum that can be shifted by altering the number of active molecular motors and cl

235 e antiretrovirals ranging from mug/d to mg/d by altering the orifice design, drug loading, and mass o

236 reasing the relative volume of airspace) and by altering the pattern of airspace distribution within

237 modulating immune components, specifically, by altering the phenotype of macrophages.

238 significantly inhibited autophagy induction by altering the phosphorylation status of mammalian targ

239 By altering the physical capacity and outlook of fishers

240 ng-term changes in coastal plant communities by altering the physical conditions that affect ecosyste

241 nisms that may promote hemin release from Hb by altering the position of its F helix.

242 e and other sleep behaviors during evolution by altering the properties of conserved arousal circuits

243 ed cell cycle arrest, apoptosis of ATC cells by altering the protein expression of cancer-related gen

244 e speed of synaptic development in two ways: by altering the rate constants of the adaptive processes

245 ggest that Snf1 may influence mRNA stability by altering the recruitment activity of the transcriptio

246 states in surface coordination architectures by altering the redox properties of organic ligands.

247 We further demonstrated its utility by altering the regulatory topology of the nisin pathway

248 the functioning of mycorrhizal associations by altering the relative degree of nutrient and carbohyd

249 own pair of 5' UTR inverted repeats that act by altering the relative fimA levels to control phase va

250 croenvironment toward an antitumor phenotype by altering the relative proportion between protumor and

251 mbionts therefore affect community structure by altering the relative success of different natural en

252 iven applied load, can be manipulated solely by altering the resistance to rotational motion of the h

253 that scaling is achieved, at least in part, by altering the sensitivity of the target cells to SHH a

254 e phenology can influence parasite epidemics by altering the sequence of infection and interactions a

255 creasing the [Cl(-) ]o from 140 to 30 mm and by altering the sequence of the first intracellular loop

256 these mutations damaged the activity of ACPT by altering the sizes and charges of key amino acid side

257 g photoreduction kinetics indirectly, likely by altering the solid:liquid water ratio.

258 d to exploit the pH of the secretory pathway by altering the spatial juxtaposition of titratable grou

259 n alters hPHPT1 activity, then it will do so by altering the stability of an intermediate state.

260 s and their concentration can be manipulated by altering the starting materials, synthesis conditions

261 By altering the status or abundance of the Bacteroides t

262 se of sex chromosome evolution, for instance by altering the strength of sexually antagonistic select

263 l barrier properties and mucosal homeostasis by altering the structure and function of epithelial int

264 2+) binding stimulates its open conformation by altering the structure of transmembrane helices that

265 tion of cell migration over the wounded area by altering the subcellular distribution of F-actin.

266 ankyrin-G regulates canonical Wnt signaling by altering the subcellular localization and availabilit

267 promote cell proliferation and tumorigenesis by altering the subcellular localization of an essential

268 by which Shigella promotes its own invasion by altering the sumoylation state of RhoGDIalpha, a mast

269 g pregnancy may impact offspring development by altering the temporal and spatial dynamics of the mat

270 th water changes the mechanism for catalysis by altering the thermodynamics for hydride transfer to C

271 hat indirectly affect termination efficiency by altering the time window in which termination can occ

272 he anchoring conditions of the substrate, or by altering the topography of the substrate's surface; s

273 ZIKV infection affects viral and human RNAs by altering the topology and function of N(6)-adenosine

274 cking alter integration site preference, not by altering the trafficking of the viral genome but by a

275 ro Spermine also inhibited biofilm formation by altering the transcription of the vps genes involved

276 Critically, by altering the two interacting loops of gamma2 and gamm

277 progress, the level of difficulty increased by altering the virtual ball mechanics and the gain betw

278 a capsid-targeting small molecule inhibitor by altering the virus's dependence on host factors norma

279 rganic compounds emitted into the atmosphere by altering the way in which ambient organic vapors inte

280 unostimulatory small molecules and biologics by altering their co-localization, biodistribution, and

281 rsity and respond to microenvironmental cues by altering their functional properties and secretory pr

282 bola virus and other filoviruses, presumably by altering their fusion with the endolysosome and deliv

283 exerts a potent influence on fusiform cells by altering their intrinsic properties, which may enhanc

284 ons of nucleoid and cytoplasmic localization by altering their length and/or translation.

285 umulated ROS disrupts mitochondrial function by altering their membrane polarity in floral tissues.

286 lls of even phylogenetically distant species by altering their membrane potential.

287 (VPpp neurons) counter osmotic perturbations by altering their release of vasopressin, which controls

288 d to mechanical changes in their environment by altering their spread area, morphology, and gene expr

289 ate might be expected to influence body size by altering thermoregulation, energetics or food availab

290 duced loss of BBB integrity and permeability by altering tight junction integrity, promoting the disp

291 e forced to remodel their signaling pathways by altering transcription, translation, and post-transla

292 of switching on and off the flagellar system by altering translational fidelity, which may serve as a

293 ion causes a range of neurological disorders by altering transmembrane ion fluxes, neuronal or muscle

294 le fronts in this mesenchymal tumor subtype, by altering tumor growth, chemosensitivity and metastati

295 have a critical role in asthma pathogenesis by altering type 17 inflammation, and thus interfering w

296 suggested to function in corneal angiostasis by altering VEGF signaling; however, the mechanism(s) un

297 ms that dominate the landscape in many areas by altering water budgets.

298 one to identify the minimal number of edges, by altering which one can efficiently improve or paralys

299 synthesis during exercise but rather adapted by altering whole body substrate utilization.

300 barrier function via the H19-encoded miR-675 by altering ZO-1 and E-cadherin expression posttranscrip