ライフサイエンスコーパス: by disrupting

1 D mutation destabilizes prefusion F proteins by disrupting a hydrogen bond network at the base of the

2 186W mutant thermally destabilizes rhodopsin by disrupting a hydrogen bond network at the receptor's

3 We inactivated spliceosomes by disrupting a metal-ligand interaction at the catalyti

4 numbers and morphology, and gene expression by disrupting a network of Ca(2+)-regulated genes.

5 ination with the PI3K inhibitor corrects MPD by disrupting a protein complex involving p85alpha, SHP2

6 which animals could gain a competitive edge by disrupting a rival bacterial community: "weeding," "s

7 cular septal defects and valve abnormalities by disrupting a signaling cascade involved in endocardia

8 f the four giant planets in the Solar System by disrupting a theoretical initial resonant chain simil

9 A20 and TAX1BP1 restrict antiviral signaling by disrupting a TRAF3-TBK1-IKKi signaling complex.

10 the migration of human and mouse phagocytes by disrupting actin cytoskeletal dynamics via activation

11 d polarized protrusion and retraction events by disrupting actin reorganization; at the molecular lev

12 s OB differentiation of IFT80-deficient OPCs by disrupting actin stress fibres and promoting cilia fo

13 dentify targets for therapeutic intervention by disrupting an essential RNA-protein interaction in pa

14 lts suggest that semaphorin activates plexin by disrupting an inhibitory plexin dimer and inducing th

15 at we suggest may promote channel activation by disrupting an interaction between IQ and the inhibito

16 A risk allele contributes to type 2 diabetes by disrupting an islet enhancer, which results in reduce

17 at the full spectrum of CPAs can be produced by disrupting AR at different developmental stages and i

18 te masculinization of the external genitalia by disrupting AR function in males with androgen insensi

19 that PSR causes paternal genome elimination by disrupting at least three histone marks following fer

20 tation, previously thought to inactivate ILK by disrupting ATP binding, significantly impairs the str

21 F123I and L225LI induce CARD11 hyperactivity by disrupting autoinhibition by the CARD11 ID.

22 ntal events such as infection or injury may, by disrupting B-cell anergy, dispose individuals toward

23 g inhibits BCR signaling and internalization by disrupting BCR-lipid raft coclustering and by inducin

24 1S) mouse induces functional retinal changes by disrupting BDNF signaling via the TrkB receptor.

25 shapes the protein's conformational dynamics by disrupting beta-sheet coupling between EF hands.

26 SPDEF induces a quiescent state in CRC cells by disrupting binding of beta-catenin to TCF1 and TCF3 a

27 a Kir2.1 homolog, Irk2, affects development by disrupting BMP signaling.

28 functional NK deficits in patients with pDGS by disrupting both beta2-integrin activation and activat

29 KZip(+) acts by disrupting both the formation and activity of Split G

30 s anterograde mitochondrial axonal transport by disrupting Ca(2+) homeostasis and effecting the Miro1

31 lp1 may interfere with neuron survival in PD by disrupting Ca(2+)-coupled glutamate uptake.

32 se model of atherosclerosis was also rescued by disrupting CCL3.

33 unds which can overcome bacterial resistance by disrupting cell membranes and it is essential to dete

34 rtical Ezrin may contribute to tumorigenesis by disrupting cell polarity, spindle orientation, and, p

35 ation confers a chronic proliferative signal by disrupting cellular iron signaling.

36 ration impairs context discrimination memory by disrupting cellular pattern separation processes with

37 adhesion but hinders migration, most likely by disrupting chemotactic gradients.

38 sts that IDH mutations promote gliomagenesis by disrupting chromosomal topology and allowing aberrant

39 omotes neurodegeneration and atherosclerosis by disrupting chromosome segregation and potentially oth

40 e risk of obesity and the metabolic syndrome by disrupting circadian and circannual rhythms.

41 DNA damage activates p53 in part by disrupting CK1alpha-MDMX interaction and reducing MDM

42 misregulation of xol-1 transcription caused by disrupting cognate signal element genes.

43 o ameliorate age-related myocardial fibrosis by disrupting collagen cross-linking through inhibition

44 nce the binding kinetics of mRNA transcripts by disrupting complex secondary structure and serve as s

45 nhibit the interaction of Efb with C3 partly by disrupting contacts essential for complex formation.

46 g in this repression mechanism was confirmed by disrupting COOLAIR production and mutating the COOLAI

47 e current experiments examined this question by disrupting corticosterone synthesis with administrati

48 ings indicate that titin mutations cause DCM by disrupting critical linkages between sarcomerogenesis

49 ther, the response timescale is altered only by disrupting cytoskeletal mechanics and is well describ

50 port that altering the cell nanoarchitecture by disrupting cytoskeletal organization leads to the att

51 ., W146C, K174E) alter Kif1a/Vamp2 transport by disrupting Dcx/Kif1a interactions without affecting D

52 Through analysis of protein turnover and by disrupting different steps in the ERAD pathway we dem

53 RPN13 can activate UCH37 by disrupting dimerization, although physiologically rel

54 f HDAC3 could be useful in treatment of CTCL by disrupting DNA replication of the rapidly cycling tum

55 rrecting the pathological structure of apoE4 by disrupting domain interaction is a potential therapeu

56 ficking impairment of apoE4 was also rescued by disrupting domain interaction with the small-molecule

57 ial step in laminin-binding glycan synthesis by disrupting dystroglycan O-mannosylation.

58 ion of laminin alpha2 impedes male fertility by disrupting ectoplasmic specialization (ES; a testis-s

59 d create an apparent force to unwrap the RNA by disrupting either the transcription complex or the an

60 Indeed, deconvoluting Ubc9 function by disrupting either the Ubc9:SLD2 or Ubc9:SUMO noncoval

61 ymphocytes trigger oxidative bacterial death by disrupting electron transport, generating superoxide

62 PBDEs may be associated with obesity by disrupting endocrine systems.

63 secreted by reactive astrocytes open the BBB by disrupting endothelial tight junctions (TJs), but the

64 l METH exposure modulates offspring behavior by disrupting epigenetic programming of gene expression

65 ses contribute to allergic disorders in part by disrupting epithelial barrier function.

66 deficiency may contribute to UC inflammation by disrupting epithelial barrier function.

67 hypothesized that aldosterone modulates PAH by disrupting ET(B)-eNOS signaling through a mechanism i

68 exposure affects cardiac development in fish by disrupting excitation-contraction (EC) coupling.

69 self-ubiquitination and protein degradation by disrupting Fbw7 dimerization.

70 s adverse neural effects are partly mediated by disrupting fetal neurogenesis.

71 ional tuning of inhibitory inputs onto DSGCs by disrupting GABA release from the presynaptic interneu

72 estigated the homeostasis of GABA metabolism by disrupting genes related to GABA metabolism and signa

73 by HDAC1, but not by HDAC3, and is abrogated by disrupting HIF1alpha-p300 interaction.

74 that contributes to periodontal pathogenesis by disrupting host-microbe homeostasis and promoting dys

75 inhibit cancerous Hsp90 chaperone activities by disrupting Hsp90/p23 interactions.

76 pairs mucosal immunity against this pathogen by disrupting IL-17 production or IL-17 receptor (IL-17R

77 ut also offer a new avenue to cancer therapy by disrupting immune components of the microenvironment

78 We addressed this problem by disrupting in vivo the interaction between miR-155 an

79 nflammation and that the disease is remitted by disrupting inflammatory and T-helper type 2 cytokine-

80 Our results indicate that PSMs function by disrupting interactions of biofilm matrix molecules,

81 Wnt signaling upregulated WBP2 by disrupting ITCH-WBP2 interactions via EGFR-mediated t

82 s in cells profoundly inhibits the WT enzyme by disrupting its ability to homotetramerize.

83 ase (NIK) and stabilizes it from degradation by disrupting its interaction with TRAF2.cIAP2 ubiquitin

84 vera (PV) and essential thrombocytosis (ET) by disrupting JAK2 protein stability.

85 e cell death pathway of invaded midgut cells by disrupting JNK signaling and prevents the activation

86 xposure inhibits the granulopoietic response by disrupting key cell signaling for hematopoietic precu

87 se persistent deficits in cognitive function by disrupting key events in brain development.

88 ins, including amyloid beta protein and tau, by disrupting key interactions involved in the assembly

89 llular transformation and cancer progression by disrupting key metabolic signaling pathways.

90 reduction of neuronal activity and enhanced by disrupting L-type calcium channels or elevating cAMP.

91 ssion and negative symptoms in schizophrenia by disrupting learning and blunting the salience of rewa

92 of cholesterol, which reduced IFNG signaling by disrupting lipid rafts, leading to reduced phosphoryl

93 othesized that BaP exerts anticancer effects by disrupting lipogenesis.

94 nt synaptogenesis phenotypes were suppressed by disrupting locomotion of the mutant animals, suggesti

95 el bacteremia and systemic infection, partly by disrupting lung epithelium through 12-LOX-dependent H

96 TAX1BP1 and A20 blocked antiviral signaling by disrupting Lys(63)-linked polyubiquitination of TBK1-

97 ell-known autophagy inhibitor that functions by disrupting lysosomal activity.

98 n with PD0325901 mimics nutrient deprivation by disrupting lysosome organization and decreasing mTORC

99 may promote skeletal muscle weakness in CNM2 by disrupting machinery necessary for excitation-contrac

100 icultural insect pest that can be controlled by disrupting male-female communication with sex pheromo

101 ) mediate gene silencing of a target protein by disrupting messenger RNAs in an efficient and sequenc

102 By disrupting microRNA (miRNA) biogenesis, we previously

103 coalescence events, which could be prevented by disrupting microtubules.

104 duces early apoptosis in innate immune cells by disrupting mitochondria membrane potential via its po

105 y animal models induce parkinsonian features by disrupting mitochondrial function.

106 odenine, mediate their antifungal activities by disrupting mitochondrial iron-sulfur (Fe-S) cluster s

107 se risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear.

108 H-L1 regulates the balance of mTOR signaling by disrupting mTORC1.

109 of exonic mutations altered splicing, mostly by disrupting multiple stages of spliceosome assembly.

110 priming function, and RIMs activate priming by disrupting Munc13 homodimerization.

111 t gltA mutation, which increases CS activity by disrupting NADH-inhibition of this enzyme, is benefic

112 uld be to protect against disease indirectly by disrupting nasopharyngeal carriage (e.g., herd protec

113 However, efforts to improve NK cell function by disrupting negative regulators that target proximal s

114 from information spreading to accessibility, by disrupting network paths.

115 Here, we tested this hypothesis by disrupting neural activity in SMA, in primary motor c

116 tribute to cognitive impairments in dementia by disrupting neuronal function in brain regions, includ

117 V-associated neurocognitive disorders (HAND) by disrupting neurotransmission including dopamine uptak

118 lts, we propose that EXPB1 loosens grass CWs by disrupting noncovalent junctions between highly subst

119 is relationship is comprehensively validated by disrupting nonfocal adhesion proteins (alpha-actinin,

120 ving cells has the potential to cause stress by disrupting normal metabolic processes.

121 that BPA exerts its effects on amelogenesis by disrupting normal protein removal from the enamel mat

122 Tumors generated by disrupting Notch signaling arose preferentially in th

123 es in the clonal raider ant, Ooceraea biroi, by disrupting orco, a gene required for the function of

124 ugh treatment with 1 can elicit side-effects by disrupting other RXR-heterodimer receptor pathways.

125 erse the excessive EMT caused by loss of Nf1 by disrupting Pdgfralpha expression in the epicardium.

126 (DP) into newly forming desmosomes, in part by disrupting PKC-dependent regulation of DP assembly co

127 n response to chemoattractants fMLF and CCL2 by disrupting polarized distribution of F-actin and Gbet

128 fibrils could play a role in amyloid disease by disrupting protein degradation by lysosomes and traff

129 titute viable targets for efflux inhibition, by disrupting protein-protein interactions between helic

130 t allosterically regulate enzymatic activity by disrupting protein-protein interactions.

131 ependent on alpha5beta1 integrin is promoted by disrupting Rabaptin phosphorylation.

132 ffeine treatment can disrupt gene conversion by disrupting Rad51 filaments.

133 also impair its reactivation by CRAF, either by disrupting RAF-MEK complexes or by interacting with S

134 NJ), prevented OC development and activation by disrupting RANKL-induced localization of TRAF6 and c-

135 ease HSC activation and fibrogenesis in vivo by disrupting receptor tyrosine kinase endocytosis and s

136 g "Broca's area," the primary language area, by disrupting regional GPR56 expression and blocking RFX

137 which may impede song and speech development by disrupting reinforcement learning mechanisms.

138 mporal dementia syndrome in C9orf72 carriers by disrupting salience network connectivity.

139 rophic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation.

140 at these structural features can be affected by disrupting sensory experience and that spine turnover

141 mouse model for MSS was previously produced by disrupting Sil1 using gene-trap methodology.

142 ecific lncRNA that safeguards the hESC state by disrupting SIRT6 activity.

143 ish EVC mutations causing EvC dwarfism do so by disrupting sonic hedgehog (Shh) signaling, our data i

144 Here we test this prediction by disrupting spatial sorting in replicated invasions of

145 lding in an ATP-dependent manner, presumably by disrupting structure in the intermediate.

146 ), receptors impairs firing rate homeostasis by disrupting synaptic homeostatic plasticity in hippoca

147 By disrupting synaptic stability at different times, we

148 nson's disease and dementia with Lewy bodies by disrupting synaptic vesicles.

149 dels predict a termination of TCR signaling, by disrupting T-APC contacts, or TCR signal modification

150 A components, underlie a number of EvC cases by disrupting targeting of both the EvC complex and SMO

151 ed meiotic checkpoint blocks Grk translation by disrupting the accumulation of grk mRNA in a translat

152 the effective stiffness of the cell membrane by disrupting the actin cytoskeleton using cytochalasin

153 at high intracellular calcium concentration by disrupting the actin-myosin ATPase pathway.

154 us r) in tomato eliminates fruit carotenoids by disrupting the activity of the fruit-specific phytoen

155 s contractility at high levels of activation by disrupting the acto-myosin ATPase cycle.

156 ariner transposase increase their activities by disrupting the allostery that normally serves to down

157 which inhibits insulin action in hepatocytes by disrupting the assembly of mTOR and rictor.

158 (PKR), and it suppresses host transcription by disrupting the assembly of the basal transcription fa

159 onic inflammation precedes hepatic steatosis by disrupting the balance between fatty acid synthesis a

160 ry response after MI and antagonizes healing by disrupting the balance between inflammation and repai

161 etes affect both functions of DCoH1, perhaps by disrupting the balance between the two DCoH complexes

162 Changes in chromosome number impair fitness by disrupting the balance of gene expression.

163 Oncogenes may drive carcinogenesis by disrupting the balanced control of cell cycle progres

164 By disrupting the Bcl-2-IP(3)R interaction, this peptide

165 preconditioning-induced autophagy, possibly by disrupting the Beclin 1/Bcl-2 interaction.

166 acetylation of Acat1 decreases its activity by disrupting the binding of coenzyme A.

167 of a genetic variant deactivating enhancers by disrupting the binding of transcription factors (TFs)

168 ine 220 (K220), which inhibits PGK1 activity by disrupting the binding with its substrate, ADP.

169 90) and GyrA(D94) cause quinolone resistance by disrupting the bridge-enzyme interaction, thereby dec

170 he other hand, this synergism was attenuated by disrupting the C/EBP binding site or knocking down C/

171 ne perturbs the shape and functions of cells by disrupting the cell signaling pathways and the format

172 that the REO acts against F. verticillioides by disrupting the cell wall and causing the loss of cell

173 ne expression and reduced locomotor activity by disrupting the central and peripheral clocks and incr

174 involvement of Cep135 in centriole function by disrupting the Cep135 gene in the DT40 chicken B-cell

175 arathyroid hormone-like hormone (PTHLH) gene by disrupting the cis-regulatory landscape.

176 surface to be regenerated after measurement by disrupting the complementary pairs above the oligonuc

177 By disrupting the conserved TAD border in one of the zeb

178 an pests, Musca domestica and Delia radicum, by disrupting the control of apoptosis.

179 vel decreases BDNF secretion from astrocytes by disrupting the conversion of GTP-Rab3a into GDP-Rab3a

180 substitutions trap the activation gate open by disrupting the coupling between the voltage-sensing u

181 is acid-base pair is initiated and preserved by disrupting the dative donation through protonation on

182 s, and externalizing problems in urban youth by disrupting the development of left hemisphere white m

183 conformational dynamics and self-association by disrupting the disulfide bridge (Cys(3)-Cys(14)) in S

184 Heretofore, HumAb mice have been generated by disrupting the endogenous mouse Ig genes and simultan

185 rkB and p75 neurotrophin receptor (p75(NTR)) by disrupting the endosomal sorting, reducing lysosomal

186 7 by blocking the ubiquitin-binding site and by disrupting the enzyme active site.

187 ase the decay rate of the bis-Fe(IV) species by disrupting the equilibrium of the resonance structure

188 address the challenge of slow mass transfer by disrupting the external depletion layer around an in

189 HQNO induces specific self-poisoning by disrupting the flow of electrons through the respirat

190 tes TGF-beta1-inducible activation of WT PFs by disrupting the formation of an inhibitory Thy-1-TGFbe

191 dification is required during FBMN migration by disrupting the function of farnesyl biosynthetic enzy

192 cute infection contributes to immune control by disrupting the function of Nef.

193 viruses can block autophagosome degradation by disrupting the function of SNARE proteins.

194 y to incorporate bad news into their beliefs by disrupting the function of the left (but not right) i

195 activation, FXR trans-repressed these genes by disrupting the functional CREB-CRTC2 complex.

196 guingly, Bcl2 directly inhibits RNR activity by disrupting the functional hRRM1/hRRM2 complex via its

197 (exp)) RNA produces a toxic gain of function by disrupting the functions of RNA splicing factors, suc

198 op (AUSL) element, "flipping" the RNA switch by disrupting the GAIT (interferon-gamma-activated inhib

199 tosynthetic arsenite oxidation was confirmed by disrupting the gene in a representative photoarsenotr

200 ng can easily generate knockout mouse models by disrupting the gene sequence, but its efficiency for

201 estigated the biological functions of RTEF-1 by disrupting the gene that encodes it in mice endotheli

202 ed form of MDP in Mycobacterium tuberculosis by disrupting the gene, namH, responsible for this modif

203 VAMP2-pHluorin, and bypass insulin signaling by disrupting the GLUT4-retention protein TUG.

204 ttenuated GDF10-dependent TGF-beta signaling by disrupting the heterodimerization of TbetaRI and Tbet

205 taining calcium-responsive alternative exons by disrupting the histone deacetylase-to-histone acetylt

206 The ability to obviate radical transport by disrupting the hydrogen bonding network of the amino

207 o act as a novel immune checkpoint inhibitor by disrupting the hypoxia-adenosine-A2aR pathway.

208 d by Glu-33 and Tyr-418 inhibits L1 adhesion by disrupting the Ig1-Ig4 interaction.

209 broad-spectrum antiviral compound that acts by disrupting the integrity of the viral membrane.

210 re hypothesized that Wnts may regulate GSK-3 by disrupting the interaction between APC and the Axin-G

211 inhibit development of peripheral neuropathy by disrupting the interaction between paclitaxel, neuron

212 cts directly and specifically on osteoclasts by disrupting the interaction between plasma membrane-di

213 istically, SMURF2 regulates RANKL expression by disrupting the interaction between SMAD3 and vitamin

214 GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD au

215 eported to suppress STING-mediated signaling by disrupting the interaction of STING and TBK1 and/or M

216 tivation of TRPA1 were selectively prevented by disrupting the interaction of the carboxy-lobe of cal

217 with non-phosphorylated NBD1, suggests that by disrupting the interaction of the NBD core with the N

218 rylation negatively regulates Sec4p function by disrupting the interaction with the exocyst complex v

219 ydrogen bonding and remodeled mature fibrils by disrupting the intermolecular salt bridge Asp23-Lys28

220 macrophages and diverse nonphagocytic cells by disrupting the internalization vesicle, releasing the

221 ed when host circadian rhythms are abolished by disrupting the key clock gene transcription factor Bm

222 ivity state, D(4) suppresses AMPAR responses by disrupting the kinesin motor-based transport of GluR2

223 r cell or ejects the drug into its cytoplasm by disrupting the liposome and endosome.

224 of genetically containing transgenic strains by disrupting the Mad2 gene.

225 adolescent cognitive and emotional outcomes by disrupting the maturation of the underlying brain net

226 expression to subvert the host immune system by disrupting the MHC-II enhanceosome through binding wi

227 t crocin inhibited cell proliferation mainly by disrupting the microtubule network.

228 knockdown of hspb7 causes laterality defects by disrupting the motility of these cilia.

229 igned to open up the NK2 closed conformation by disrupting the N/K2 interface convert NK2 from a Met

230 amics interferes with neurite outgrowth, not by disrupting the net assembly of MTs at the growth cone

231 ronal and synaptic injury, at least in part, by disrupting the normal copper-mediated, PrP(C)-depende

232 of analog and digital transmission, possibly by disrupting the normal stoichiometry of presynaptic po

233 g protein, but not repeat RNA, is pathogenic by disrupting the nuclear lamina.

234 and excessive worry about everyday problems by disrupting the online updating ("reality check") of t

235 By disrupting the ORF MXAN7041 in two different sublines

236 rimental evidence to support that ovulation, by disrupting the ovarian surface epithelium and releasi

237 role in neuroprotection, during the insult, by disrupting the p38 MAPK pathway.

238 Recovery of p53 function by disrupting the p53-MDM2/MDMX interaction using small-

239 nfluenza A vRNPs and inhibits their activity by disrupting the PB2-NP interaction.

240 hat can suppress influenza virus replication by disrupting the polymerase assembly.

241 We manipulated PcG clusters by disrupting the polymerization activity of the sterile

242 unities to interfere with herpes replication by disrupting the precise force balance between the enca

243 titive inhibitor of ERalpha and AR signaling by disrupting the Pus1p-SRA-steroid receptor axis.

244 tions lead to increased self-oligomerization by disrupting the PYD and LRR domains, which are essenti

245 d gain of Evi5 function blocked BC migration by disrupting the Rab11-dependent polarization of active

246 nally, we show that this mutation impairs HR by disrupting the RAD51D-XRCC2 interaction and confers P

247 in A cleavage mimics the effects of progerin by disrupting the Ran gradient, but the effects on Ran a

248 , preventing the formation of nuclear 'gems' by disrupting the recruitment of the protein to Cajal bo

249 used not only by protein alteration but also by disrupting the regulation of another gene.

250 e, this mislocalization defect is suppressed by disrupting the retrograde motor, the cytoplasmic dyne

251 protein that protects host genome integrity by disrupting the retroviral capsid as it transports vir

252 TRIM27 protein levels were restored by disrupting the RING domain of ICP0 or by inhibiting t

253 138K) affects access to the RPV binding site by disrupting the salt bridge between p51(E138) and p66(

254 ng csgD (agfD), the master biofilm regulator by disrupting the silenced, H-NS-bound promoter.

255 ans and human mesenchymal stem cells (hMSCs) by disrupting the SKN-1/Nrf2-mediated oxidative stress r

256 he striatal representation of value, perhaps by disrupting the striatal population that normally repr

257 cline of coral reef ecosystems, particularly by disrupting the symbioses between reef-building corals

258 By disrupting the Tbsnm1 gene, we demonstrate that TbSNM

259 ive ligands indirectly inhibited TCR binding by disrupting the TCR-CD1a contact zone.

260 ding protein, which enhanced ASK1 activation by disrupting the thioredoxin-ASK1 complexes.

261 We generated HAT-L4 knockout mice by disrupting the Tmprss11f gene encoding HAT-L4.

262 linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex.

263 ng that alpha-syn impairs lysosomal function by disrupting the trafficking of lysosomal hydrolases.

264 eliminate lymphoma CSCs in vitro and in vivo by disrupting the transcriptional function of HIF1alpha,

265 eural processes might contribute to seizures by disrupting the transmembrane ion gradients that subse

266 that the growth phenotype can be suppressed by disrupting the tRNA modification gene mnmE.

267 ties to fine-tuning in a controllable manner by disrupting the weak halogen bonds between the molecul

268 Rendering adult nephrocytes dysfunctional by disrupting their endocytic function or temporally con

269 tions of beta1 NPXY motifs induce phenotypes by disrupting their interactions with critical integrin

270 R-1 and miR-206, but not the miR-133 family, by disrupting their RISC association.

271 ceptor conformation and G protein activation by disrupting them in the chemokine receptor CXCR4, whil

272 By disrupting these hydrogen bonds, we are able to gener

273 d thus improvements in ZT are still possible by disrupting these modes.

274 By disrupting this allosterically regulated assembly mec

275 ns can cause loss of function in the nucleus by disrupting this assembly and chromatin binding.

276 nhibits VEGFR2 phosphorylation and signaling by disrupting this association.

277 he impact of attempting to control outbreaks by disrupting this cycle.

278 wn attention can affect the saliency signals by disrupting this feedback through its action on the sa

279 By disrupting this PAR4 calcium/beta-arrestin signaling

280 nce to stress-induced behavioral disturbance by disrupting this signaling mechanism.

281 ial cells and HIV trafficking into the brain by disrupting tight junction (TJ) integrity at the blood

282 primary immunodeficiencies may cause disease by disrupting transcription factor binding.

283 pithelial enhancers and alter their activity by disrupting transcription factor motifs that overlap t

284 n diminished accessibility at targeted sites by disrupting transcription of EWSR1-FLI1.

285 h these diseases: loss of function typically by disrupting transcription of the mutated gene, RNA tox

286 ide abolished TRPC3-regulated ROS production by disrupting TRPC3-Nox2 interaction, without affecting

287 nalogues maintain their mechanisms of action by disrupting tubulin polymerization, similar to their p

288 ing apoptosis and/or necrosis and indirectly by disrupting tumor vasculature and increasing tumor imm

289 By disrupting two evolutionarily conserved domains of CD

290 for xylose metabolism in E. coli was blocked by disrupting two genes (xylA and EcxylB) encoding xylos

291 moving RPE miRNA regulatory activity in mice by disrupting two independent and essential steps of miR

292 sform meiosis I into a mitosis-like division by disrupting two key meiosis I events: coorientation of

293 une system may confer risk for schizophrenia by disrupting typical synaptic pruning in late adolescen

294 uolar pH do not limit mitochondrial function by disrupting vacuolar protein degradation, but rather b

295 bed to prevent myofibroblast differentiation by disrupting, via distinct mechanisms, the actions of b

296 membranes early in the replication cycle and by disrupting viral particle egress in the late stage of

297 515) can inhibit influenza virus replication by disrupting viral RNA promoter binding activity of pol

298 By disrupting WASP autoinhibition, mycolactone leads to

299 ion 1 likely affects affinity of DNA binding by disrupting water-mediated interactions with the DNA m

300 vironment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addi