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1 C25A25 is thought to control ATP homeostasis by functioning as a Ca(2+)-regulated shuttle of ATP-Mg(2

2 y, Scn1bb plays critical developmental roles by functioning as a CAM in the zebrafish embryonic nervo

3 criptional control of gene expression, often by functioning as a chaperone for regulatory sRNAs.

4 Thus, by functioning as a co-sigma factor that interacts with

5 Thus, by functioning as a coincidence detector of chemotactic

6 gest that ARFGAP1 promotes vesicle formation by functioning as a component of the COPI coat.

7 ears to modulate polysaccharide chain length by functioning as a concentration-dependent kinetic timi

8 te to cytoplasmic localization of MondoA-Mlx by functioning as a CRM1-dependent nuclear export signal

9 ponsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between ME

10 use osteoprotegerin suppresses bone turnover by functioning as a decoy receptor for osteoclast differ

11 that PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate bindin

12 regulates anterior-posterior axis patterning by functioning as a direct-acting nanos mRNA localizatio

13 role in 17-AAG-mediated anticancer activity by functioning as a downstream target or by modulating i

14 hus, salvador restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation

15 We suggest that by functioning as a FoxO1 E3 ligase, COP1 may play a rol

16 the DrrA protein stimulated Rab1 activation by functioning as a guanine nucleotide exchange factor.

17 ilitates trophectoderm lineage specification by functioning as a key regulator of Cdx2 transcription,

18 The histidine sensor kinase ResE, by functioning as a kinase and a phosphatase for the cog

19 ated JNK pathway influences axonal transport by functioning as a kinesin-cargo dissociation factor.

20 By functioning as a leak pathway for protons, the Na(+)/

21 ncer by promoting G1-S progression, possibly by functioning as a licensing factor for DNA replication

22 gene expression at the transcriptional level by functioning as a ligand for estrogen receptor alpha (

23 his receptor can also regulate transcription by functioning as a ligand-controlled DNA architectural

24 dylinositol-3-kinase (PI3K)/Akt/mTOR pathway by functioning as a lipid phosphatase.

25 l as vascular and hematopoietic development, by functioning as a master regulator of angiogenic facto

26 tumor cells promotes growth and angiogenesis by functioning as a master regulator of vascular endothe

27 to contribute to human melanoma progression by functioning as a mitogenic and angiogenic factor.

28 ndicate that Fbln5 promotes PDAC progression by functioning as a molecular rheostat that modulates ce

29 l infection in the peripheral nervous system by functioning as a molecular switch for ICP34.5 express

30 ptive responses to drought and salt stresses by functioning as a negative component of stress-mediate

31 versatile role in cytoplasmic mRNA turnover by functioning as a negative regulator in an isoform-spe

32 i controls cell-type proportioning, possibly by functioning as a negative regulator of a pathway medi

33 defense against P. carinii in vivo, perhaps by functioning as a nonimmune opsonin.

34 4 phosphorylation and signaling, most likely by functioning as a nonspecific CXCR4 antagonist.

35 also influence MHC class I peptide selection by functioning as a peptide exchange catalyst.

36 or and that COR exerts its virulence effects by functioning as a potent agonist of this receptor syst

37 6K2 regulation than does the S6K1 C terminus by functioning as a potent inhibitor of activation by va

38 e could potentially regulate gene expression by functioning as a protein 'displacer' to modulate prot

39 othesis that K3L inhibits eIF-2alpha kinases by functioning as a pseudosubstrate, we observed that K3

40 mplex that facilitates ERK cascade signaling by functioning as a Raf family N-Region kinase.

41 in is thought to restrict cell proliferation by functioning as a Ras-specific guanosine triphosphatas

42 modulate transcription of rRNA gene in vivo by functioning as a repressor (homodimer) or activator (

43 he antigen receptor complex in T lymphocytes by functioning as a scaffold coordinating the activities

44 me and pH(i) through Na(+)/H(+) exchange and by functioning as a scaffold for recruitment of a signal

45 ulatory role in NF-kappaB signaling pathways by functioning as a scaffold to recruit kinase complexes

46 P1 is essential for liver infection possibly by functioning as a selective regulator controlling the

47 mediates its anti-oncogenic effect on cells by functioning as a sequence-specific regulator.

48 TGF-beta-induced transcriptional activation by functioning as a Smad-dependent co-repressor.

49 role in the construction of mammalian brain by functioning as a source of new neurons and by providi

50 ric hindrance produced by the cargo protein, by functioning as a spacer to which cytosolic translocat

51 tains human embryonic stem cell self-renewal by functioning as a sponge to trap miR-145, thus regulat

52 sm6 additionally contributes to interference by functioning as a standalone RNase that degrades invad

53 n regulating the catalytic activity of Ubc13 by functioning as a stochastic active site gate, which i

54 iffers from its cellular counterpart, c-Qin, by functioning as a stronger transcriptional repressor a

55 ss-links to buccal epithelial cells in vitro by functioning as a substrate for mammalian transglutami

56 ant role in inflammatory bowel disease (IBD) by functioning as a Th1-polarizing cytokine.

57 also been shown to regulate gene expression by functioning as a transcription corepressor.

58 While Ngn1 promotes neurogenesis by functioning as a transcriptional activator, Ngn1 inhi

59 nstrated that it did not enhance translation by functioning as a transcriptional promoter, enhancer,

60 lymphoma (NHL-B) survival and proliferation by functioning as a transcriptional regulator through a

61 modulating the response to oxidative stress by functioning as a transdominant repressor of Nrf2-medi

62 (UVR8) specifically mediates these responses by functioning as a UV-B photoreceptor.

63 at ZMC1 increases intracellular [Zn(2+)]free by functioning as a Zn(2+) ionophore, binding Zn(2+) in

64 Other lipids activate CD1-restricted T cells by functioning as adjuvants.

65 tors regulate inflammatory and immune events by functioning as agonists or antagonists of cytokine si

66 to play a critical role in the visual cycle by functioning as an acceptor of 11-cis-retinol from the

67 lays a role in FcepsilonRI-induced secretion by functioning as an adapter or linker molecule.

68 fferentially regulates various Drp1 isoforms by functioning as an allosteric effector of cooperative

69 (miR-126) facilitates vascular regeneration by functioning as an angiomiR and by modulating mobiliza

70 portant role in negative cell growth control by functioning as an apoptotic effector of p53 tumor sup

71 in's high stimulated rates of GTP hydrolysis by functioning as an assembly-dependent GAP.

72 ional activity and promoting its degradation by functioning as an E3 ubiquitin ligase.

73 PAP suppresses pain by functioning as an ecto-5'-nucleotidase.

74 hat RGS2 selectively blocked slow inhibition by functioning as an effector antagonist, rather than as

75 iii) without metal oxidation state changes - by functioning as an electron reservoir - to intramolecu

76 es in kidney development and pathophysiology by functioning as an endogenous inhibitor of TGF-beta si

77 dicated to regulate SOC and I(crac) channels by functioning as an endoplasmic reticulum Ca2+ sensor,

78 NSP4 plays a role in rotavirus pathogenesis by functioning as an enterotoxin.

79 SP4 causes diarrhea in 6- to 10-day-old mice by functioning as an enterotoxin.

80 MSP promotes meiotic resumption by functioning as an ephrin-signaling antagonist and by

81 tor that promotes osteoblast differentiation by functioning as an ER Ca(2+) channel and a hemichannel

82 actor (LRF) is necessary for HSC maintenance by functioning as an erythroid-specific repressor of Del

83 e termination of NF-kappaB and JNK signaling by functioning as an essential regulator of A20.

84 t not TIM-3 or TIM-4, promotes HCV infection by functioning as an HCV attachment factor.

85 ed that the HBeAg may promote HBV chronicity by functioning as an immunoregulatory protein.

86 in-alpha1 negatively regulates ARF6 activity by functioning as an in vivo PIP3-dependent ARF6 GAP.

87 atase, PTEN, has a novel role in the nucleus by functioning as an indispensible regulator with SRF to

88 ins into designated subcellular compartments by functioning as an intracellular "zip code." In the pr

89 role in ischemia/reperfusion injury not only by functioning as an intracellular antioxidant but also

90 s shown to stimulate Ras-activating proteins by functioning as an intracellular cytoplasmic activator

91 ergy balance and pigmentation, respectively, by functioning as antagonistic ligands at their cognate

92 crophages in turn restore tissue homeostasis by functioning as anti-inflammatory cells, and macrophag

93 lls can directly influence adaptive immunity by functioning as antigen-presenting cells.

94 nstrated that these vaccines induce immunity by functioning as APCs for endogenously synthesized, tum

95 ptide receptors and induce apoptosis in SCLC by functioning as biased agonists that stimulate discord

96 tissue engineering and regenerative medicine by functioning as biomimetic substrates to manipulate ce

97 ng the transcriptome of a bacterial pathogen by functioning as both a degradative enzyme and an RNA m

98 , we show that Cool-1 performs this function by functioning as both an upstream activator and downstr

99 bit replication of plus-stranded RNA viruses by functioning as cell-intrinsic restriction factors of

100 R-Vs drive resistance to AR-targeted therapy by functioning as constitutive and independent effectors

101 group play a large role in sexual isolation by functioning as contact pheromones influencing mate re

102 f pectin that activate plant innate immunity by functioning as damage-associated molecular patterns (

103 olog Apaf-1 play a central role in apoptosis by functioning as direct activators of death-inducing ca

104 e in regulating signal transduction pathways by functioning as E3 ubiquitin ligases.

105 cal textbooks could support this improvement by functioning as educational resources and as reference

106 confer multidrug resistance to cancer cells by functioning as energy-dependent efflux pumps.

107 ere that Msb3p and Msb4p regulate exocytosis by functioning as GAPs for Sec4p in vivo.

108 signaling (RGS) modulate G protein activity by functioning as GTPase-activating proteins (GAPs) for

109 jor determinants of minor-groove recognition by functioning as H-bond donors to the O2 of thymine res

110 h as Vg1 and Xwnt-11, can specify cell fates by functioning as inducers or patterning agents.

111 receptors mediate fast synaptic transmission by functioning as ligand-gated ion channels.

112 cules confer increased vancomycin-resistance by functioning as molecular decoys that titrate the anti

113 By functioning as molecular glue, Arbidol stabilizes the

114 ocytic trafficking of cell surface receptors by functioning as monomeric CLATHRIN-associated sorting

115 tides represent critical prosurvival factors by functioning as natural inhibitors of apoptosome forma

116 to govern carbon catabolite repression (CCR) by functioning as negative cis elements in gram-positive

117 alloantibodies facilitate cellular rejection by functioning as opsonins to enhance T cell activation

118 ds that can help to mitigate climatic stress by functioning as osmoregulators and antioxidants, inclu

119 tly stabilized nascent blood vessels in vivo by functioning as perivascular precursor cells.

120 ess UGGAAexp-mediated toxicity in Drosophila by functioning as RNA chaperones for proper UGGAAexp fol

121 and directly repress bam expression in GSCs by functioning as short-range signals.

122 racellular antagonists to cytokine signaling by functioning as soluble decoy receptors.

123 ogy (DH) domains activate Rho-family GTPases by functioning as specific guanine nucleotide exchange f

124 ccommodating abnormally large linear strains by functioning as supramolecular springs.

125 or control of HSV and VZV IE gene expression by functioning as the common element for distinct factor

126 omplex, mTORC2, regulates cell proliferation by functioning as the regulatory kinase of Akt and other

127 igration and outgrowth in the nervous system by functioning as unconventional Goalpha-coupled recepto

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