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1 eatures of human melanomagenesis was created by inducing a BRafV600E-driven melanomagenic program in
2 activation triggers down-regulation of Kv1.3 by inducing a clathrin-mediated endocytic event that tar
3 irectly activating its proapoptotic activity by inducing a conformational change enabling formation o
4 cue that entrains circadian rhythms and also by inducing a direct and rapid regulation of behavior.
5 vents the development of lung adenocarcinoma by inducing a further increase in MAPK signalling that r
8 treatment elicited mitochondrial dysfunction by inducing a loss of mitochondrial membrane potential.
10 mediates the control of liver-stage P. vivax by inducing a noncanonical autophagy pathway resembling
12 cy in activating human and mouse neutrophils by inducing a rise in intracellular Ca(2+) concentration
13 monstrate that NR prevents and reverts NAFLD by inducing a sirtuin (SIRT)1- and SIRT3-dependent mitoc
14 in polymerization can bypass the instability by inducing a smooth transition from an open to a closed
15 the p97 N-terminal domain dislodges ataxin3 by inducing a steric clash between the D1-domain and ata
16 rm dimer contacts but enable dimer formation by inducing a strong membrane curvature of approximately
17 y tumours and non-irradiated distant tumours by inducing a strong tumour-specific immune response.
18 /3(5D) completely protects swine against FMD by inducing a strong type I IFN response and highlights
20 labelled beta-lactoglobulin amyloid fibrils by inducing a temperature gradient across a microfluidic
21 s its cytoprotective effect on ISR signaling by inducing a transient adaptive reprogramming of global
23 NIs exhibit a multimodal mechanism of action by inducing aberrant IN multimerization during virion mo
25 how that auxin acts in the epidermis in part by inducing activity of the locally acting, growth-promo
29 ed, TrxR1 depletion reduces myoblasts growth by inducing an early myogenesis -related gene expression
30 frequency-conversion processes are obtained by inducing an effective second order susceptibility via
31 R4 in atherosclerosis and plaque composition by inducing an endothelial cell (BmxCreER(T2)-driven)-sp
33 ns predispose to autism, at least partially, by inducing an Ih channelopathy that may be amenable to
34 inding 7-CKA to GluD2-LBD differs from D-Ser by inducing an intermediate cleft closure of the clamshe
35 ant functions in GC B cells and plasma cells by inducing and maintaining DNase I hypersensitive sites
36 ions by activating the Notch/Dll pathway and by inducing anti-angiogenic effects at the maternal-feta
37 side effects in the A375-bearing mice model by inducing apoptosis and reducing cell proliferation an
39 In summary, GE exerts anticancer activities by inducing apoptosis and suppressing migration and inva
40 r cells upon irradiation with light directly by inducing apoptosis and/or necrosis and indirectly by
42 prevents the emergence of transformed cells by inducing apoptosis or senescence, among other respons
43 promising agents for the treatment of cancer by inducing apoptosis though their preferential binding
47 yanin exerts anti-pancreatic cancer activity by inducing apoptotic and autophagic cell death, thereby
48 se results suggest the potential for success by inducing AQP1 expression in human salivary ductal cel
50 and increased macrophage cholesterol efflux by inducing ATP-binding cassette subfamily A member 1 (A
52 henotype and mitigated pathogenic tau levels by inducing autophagic pathways in a Drosophila model of
53 ertain nutrients such as glucose or nitrogen by inducing autophagy, reclaiming pieces of proteins for
54 rthotopically implanted Panc-1 tumors by 80% by inducing autophagy-mediated apoptosis in the tumors.
56 LRP emerge through overlying root tissues by inducing auxin-dependent cell separation and hydrauli
57 antibody levels and promoted lupus nephritis by inducing BAFF production in the kidneys, and the form
58 proaches could find therapeutic applications by inducing beta cell conversion in vivo or by reprogram
60 entiation and the self-renewal of stem cells by inducing beta-catenin-dependent signalling through th
61 ers cell proliferation in human cancer cells by inducing both apoptosis and cell cycle arrest, and th
62 roteins regulated class switch recombination by inducing both Igh germline transcription and AID expr
63 tripes improves current NMJ-in-a-dish models by inducing both mouse and human myoblast durotaxis to s
64 ex mediates Cingulin recruitment to the AMIS by inducing branched actin formation, and that Cingulin
67 in misfolding and aggregation was determined by inducing carbonyl stress in young mice, which recapit
69 kinase A inhibitor blocks cell proliferation by inducing cell cycle arrest in G2 phase, as well as ap
70 n depletes the distal airway progenitor pool by inducing cell death and loss of progenitor function,
71 tly reduces the overall number of metastases by inducing cell death in lesions of all sizes, challeng
74 eukemia (PML) plays a tumor suppressive role by inducing cellular senescence in response to oncogenic
75 rimes the neonatal adaptive immune processes by inducing changes to the exometabolomic profile of fet
76 beam direction can be steered parsimoniously by inducing changes to the pattern of phase differences
81 We conducted parallel studies in Drosophila by inducing conditional knockdown of the POGZ ortholog r
82 HMAb mediates virus neutralization, in part, by inducing conformational change to the targeted epitop
83 IFN-gamma disassembled a subset of enhancers by inducing coordinate suppression of binding by MAF, li
84 er promotes the functional dynamic allostery by inducing coordinated motions that spread across the k
85 y killing them directly (lethal effects) and by inducing costly antipredator behaviours in living pre
86 enic actions in marrow stromal cell cultures by inducing Cox2 and receptor activator of nuclear facto
88 , rituximab can modulate the immune response by inducing cytokine secretion, especially IL-10 and MIP
90 , reduce levels of HBV cccDNA in hepatocytes by inducing deamination and subsequent cccDNA decay.
91 at PRRSV antagonizes the JAK/STAT3 signaling by inducing degradation of STAT3, a master transcription
92 kappaB exerts its anti-inflammatory activity by inducing delayed accumulation of the autophagy recept
93 promotes maintenance of self-renewing cells by inducing derepression of megabase-sized gene domains
94 roles in orchestrating the antiviral defense by inducing direct antiviral activities and shaping the
95 in LL-37 mediates an antiviral effect on RSV by inducing direct damage to the viral envelope, disrupt
96 and TFE3 enhance cellular response to stress by inducing direct transcriptional upregulation of ATF4
97 e H3 methylation as well chromatin structure by inducing DNA-chromatin loops connecting the 5' and 3'
98 1 regulates dorsal arch development not only by inducing dorsal Jag1 expression but also by inhibitin
100 reduces proliferation of HR-defective cells by inducing DSB accumulation, checkpoint activation, and
103 have revolutionized the treatment of cancer by inducing durable immune responses and clinical remiss
104 AP (HFM) diet increases visceral nociception by inducing dysbiosis and that the FODMAP-altered gut mi
108 nematode LIII larvae promote beetle pupation by inducing ecdysone production in the beetle and up-reg
112 the growth of glucose-fermenting yeast cells by inducing endocytosis and degradation of the glucose s
114 vely disabled a host mechanism of protection by inducing endogenous neuraminidase activity, which acc
116 poptosis in type 1 diabetes at least in part by inducing endoplasmic reticulum (ER) stress and the co
119 the development of mature psoriatic plaques by inducing epidermal hyperplasia, epidermal cell prolif
120 plays a key role in growth plate maturation by inducing Erk1/2 (Mapk3/1) phosphorylation, leading to
122 ally expressed Fgf initiates SAG development by inducing expression of Neurogenin1 (Ngn1) in the floo
123 o system in a behaviorally relevant context, by inducing expression of optogenetic tools in neurons u
124 cium/calmodulin-dependent kinase II and also by inducing expression of PSD-95 and synaptophysin.
125 s Chinmo/Imp to Syncrip/Broad/E93 transition by inducing expression of the Ecdysone receptor in mid-l
126 val of MYC-driven MB cells in vitro, in part by inducing expression of the FOXO1 tumor suppressor gen
129 removal vs. control treatments), and in 2013 by inducing flowering in a greenhouse before placing pla
130 action are perfectly tuned to their function by inducing formation of a channel whose dimensions are
131 d into virions and inhibit viral replication by inducing G-to-A hypermutation, it is not known whethe
132 gnificantly inhibited HCC cell proliferation by inducing G1/S transition arrest and downregulating cy
133 yl amine shows cytotoxicity for cancer cells by inducing G2/M phase cell cycle arrest and apoptosis.
134 ignaling contributes to diabetic nephropathy by inducing genes involved in leukocyte infiltration, ce
136 A431 and SCL-1 inhibited cell proliferation by inducing growth arrest during the G1/S phase transiti
138 different abiotic-stress conditions, mainly by inducing heat shock proteins and supporting a conserv
140 engaged HER2 and IL13Ralpha2 simultaneously by inducing HER2-IL13Ralpha2 heterodimers, which promote
141 ) binding activates the receptor kinase BRI1 by inducing heterodimerization with its co-receptor kina
142 high glucose impairs keratinocyte migration by inducing high levels of MMP9 expression and establish
143 t HIV-1 replication during virion maturation by inducing hyper- or aberrant IN multimerization but ar
144 own-regulated the expression of CIITA/MHC-II by inducing hypermethylation in histone H3 lysine 9 (H3K
145 ythmia, and contribute to cardiac remodeling by inducing hypertrophic signaling, apoptosis, and necro
146 in mechanical model of acute ischemic stroke by inducing hypothermia, a condition shown by itself to
147 , and altering the cellular microenvironment by inducing hypoxia increases the nuclear accumulation o
152 strated that TWIST1 promoted atherosclerosis by inducing inflammation and enhancing EC proliferation
153 endrocytes promote motor neuron degeneration by inducing inflammation and necroptosis in a manner dep
154 adipocytes inhibit B lymphopoiesis in vitro by inducing inflammatory myeloid cells, which produce IL
155 crucially involved in the pathogenesis of AD by inducing inflammatory responses and regulating tolero
156 he critical role of these cells was verified by inducing injury in recombinase-activating gene 2 KO m
157 t-derived LCN2 maintains glucose homeostasis by inducing insulin secretion and improves glucose toler
158 the transmembrane transcription factor TcpP by inducing intermolecular disulphide bonds in the TcpP
162 press Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of
164 ction resulted in the stabilization of CHMP5 by inducing its interaction with the deubiquitinase USP8
165 thelial cells and vascular endothelial cells by inducing its own endocytosis, but the mechanism by wh
166 bly complex (LUBAC), regulates cell survival by inducing linear ubiquitination of NF-kappaB signaling
168 ial growth factor VEGF-D promotes metastasis by inducing lymphangiogenesis and dilatation of the lymp
169 proinflammatory environment in aortic tissue by inducing M1 polarization, and neutralization of EDPs
170 e, we establish a female mouse model of RSDS by inducing male aggression toward females through chemo
171 e lattice, whose number is largely increased by inducing materials fatigue that depends on mechanical
173 We investigated the underlying mechanisms by inducing MI in a well-established model of T2DM and c
174 cytokine, IFN-gamma drives neuropathic pain by inducing microglial activation in the spinal cord.
175 in type X collagen, which increase ER stress by inducing misfolding of the mutant protein and subsequ
177 4-HSL significantly decreased cell viability by inducing mitochondrial dysfunction and activating cel
178 nt cells and augmented the efficacy of MAPKi by inducing mitochondrial dysfunction and inhibiting tum
181 ficity and a long-lasting therapeutic effect by inducing myelin-specific regulatory T (Treg) cells.
182 uced in vivo melanoma growth in C57BL/6 mice by inducing necrotic death of tumor cells, without causi
185 hored polyubiquitin achieves this regulation by inducing NEMO conformational change by an allosteric
186 tivated influenza vaccines confer protection by inducing neutralizing antibodies efficiently against
188 icles may contribute to chronic inflammation by inducing neutrophil chemotaxis, and the reduction of
189 terpillars and differ from all other viruses by inducing nuclear lysis followed by cleavage of host c
190 precluded senescence mediated by p16(INK4a) by inducing nuclear translocation of Bmi1 because of sus
194 nsulin-increases cardiovascular disease risk by inducing oxidative stress, inflammation, and endothel
195 the nascent RNA and influences transcription by inducing pausing and facilitating the process of tran
196 ries can effectively block crack propagation by inducing phase transformation and delocalization of d
197 have the potential to impact food allergens by inducing physical and/or chemical changes to the prot
198 D1 inhibits axonal transport of mitochondria by inducing PINK1/Parkin-dependent Miro1 degradation.
199 1-Ten contributes to the pathogenesis of DKD by inducing podocyte hypertrophy under high glucose cond
200 generation causes mitochondrial dysfunction by inducing post-translational modifications of mitochon
203 B-cell commitment in a permissive manner: FL by inducing proliferation of Ly6D(+)CD135(+)CD127(+)CD19
204 ics used in the clinic, killing cancer cells by inducing prolonged mitotic arrest that activates intr
205 pha (NF-kappaB inhibitor) and establish that by inducing prolonged NF-kappaB activation and expressio
209 regulate energy expenditure in living cells by inducing proton leakage across the mitochondrial inne
212 that hypoxic stress compromises CPC function by inducing quiescence in part through downregulation of
213 ids or glucose facilitates mTORC1 activation by inducing RagA GTPase recruitment of mTORC1 to the lys
214 emonstrate that T1-IFN augments cytotoxicity by inducing rapid phosphorylation of STAT4, resulting in
216 rimarily functions as an inflammation switch by inducing reactive oxygen species that, on one hand, i
217 ides are able to overcome RDEB PTC mutations by inducing "read-through" and incorporation of an amino
218 iously unappreciated role in lupus nephritis by inducing renal TLSs and regulating the position of T
219 2 signal instructs polyploid macrophage fate by inducing replication stress and activating the DNA da
221 position negatively affects cardiac myocytes by inducing sarcolemmal injury, generating reactive alde
224 P7 then kept cancer cells in a dormant state by inducing senescence, reducing "stemness," and activat
225 trointestinal (GI) epithelial cell membranes by inducing several signals through lipid raft organizat
229 cer and GPCR-family protein Smoothened (Smo) by inducing Smo phosphorylation, but whether Smo is acti
231 on eliminating SRSF6 expression in CRC cells by inducing SRSF6(+intron 2) transcripts which were cons
232 arcating boundaries of individual organelles by inducing stochastic 'flickers' of membrane potential,
233 SLP is able to activate fibrocytes, probably by inducing stromal cell-derived factor-1 (also termed C
234 rs and/or consistently boosts brain function by inducing structural and neurochemical changes in the
235 ession contributes to the pathogenesis of AD by inducing synaptic dysfunction and cognitive deficits
236 ould contribute to contextual fear responses by inducing synchronized activity in the mPFC and amygda
237 reasoned that inhibiting aerobic respiration by inducing systemic hypoxaemia would alleviate oxidativ
239 ticipates in the pathogenesis of the disease by inducing T helper 1 (Th1) and Th17 cells in the pancr
240 igh salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells, which can also con
241 that TDBs trigger T cell receptor activation by inducing target clustering and exclusion of CD45 phos
242 l restriction factor that prevents infection by inducing the abortive disassembly of capsid cores rec
243 ms2 gene recapitulated the palmitate effects by inducing the accumulation of SM precursors and impair
244 e homeostasis in cells instigates cell death by inducing the caspase-mediated intrinsic pathway of ap
246 that are well known to promote plant growth by inducing the degradation of a class of nuclear growth
247 tes transcription of stress-responsive genes by inducing the degradation of the transcriptional repre
248 cellular vacuolar pathogen Toxoplasma gondii by inducing the destruction of the parasitophorous vacuo
250 rs to lymphatic vessels and LEC permeability by inducing the dissociation of VE-cadherin junctions be
251 ived-TxA2 elicits a full neutrophil response by inducing the endothelial expression of ICAM-1, intrav
254 iption factor that controls T cell tolerance by inducing the expression of a large repertoire of gene
256 bverts the short 48-h life span of monocytes by inducing the expression of cellular antiapoptotic pro
257 milar antiviral and protective effects occur by inducing the expression of human HO-1 in MHC class II
258 ferons (IFNs) exert their anti-viral effects by inducing the expression of hundreds of IFN-stimulated
259 aping innate and adaptive antiviral immunity by inducing the expression of IFN-stimulated genes (ISGs
260 y, LXR ligands further modulate IL-18 levels by inducing the expression of IL-18BP, a potent endogeno
261 r IRF-3 mediates cellular antiviral response by inducing the expression of interferon and other antiv
262 a mechanism to cope with proteotoxic stress by inducing the expression of molecular chaperones and o
264 chief coordinators of meningeal inflammation by inducing the expression of proinflammatory cytokines,
265 ian cancer stemness and cisplatin resistance by inducing the expressions of pluripotent molecules Sox
266 mechanism, downregulates Mst1/Mst2 activity by inducing the formation of inactive Mst1/Mst2 heterodi
267 S that reveals a unique inhibition mechanism by inducing the general base His179 to shift out of the
268 ifficult to process, Escherichia coli adapts by inducing the high-level expression of sulfur-compound
270 ory cytokines, including IL-1beta and IL-18, by inducing the oligomerization of the multiprotein comp
271 status of these nodal factors can be altered by inducing the OsMADS1-GR fusion protein and present a
272 ne recognition receptors dampen inflammation by inducing the production of anti-inflammatory mediator
273 r vemurafenib accelerates skin wound healing by inducing the proliferation and migration of human ker
274 tely initiate their inactivation genome-wide by inducing the redistribution of somatic TFs away from
275 vironment to promote MRSA CAUTI pathogenesis by inducing the release of Fg, which the pathogen enhanc
276 nd PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall around codon 34, media
278 , lead to juvenile-onset Parkinson's disease by inducing the selective death of midbrain dopaminergic
279 ins cellular reduction-oxidation homeostasis by inducing the transcription of an array of cytoprotect
280 expansion in response to polyclonal stimuli by inducing their apoptosis and promoting their conversi
281 ose a strategy to eliminate mesenchymal TICs by inducing their conversion to more epithelial counterp
282 as been shown to promote leukocyte responses by inducing their migration and expression of inflammato
285 vert into a meiotic germ cell-like phenotype by inducing them with a combination of selected key germ
286 tension, but also drive blastoderm thinning by inducing tissue contraction through radial deep cell
290 cose repression of mitochondrial respiration by inducing transcription of the TCA cycle and OXPHOS ge
291 for the regulation of transposable elements, by inducing transcriptional silencing or post-transcript
292 nces invasion and metastasis at least partly by inducing translation elongation of VIM and RAC1 mRNAs
294 multiple in vitro and in vivo models of TNBC by inducing two terminal responses: apoptosis and senesc
295 chitosan promotes dendritic cell maturation by inducing type I interferons (IFNs) and enhances antig
296 Itch plays major roles in signaling pathways by inducing ubiquitylation-dependent degradation of seve
298 for producing cellular structures implicitly by inducing viscous thread instability when extruding ma
300 rity of malignancies and drive tumorigenesis by inducing widespread transcriptional reprogramming tha
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