ライフサイエンスコーパス: by inhibiting

1 malarial drugs that can suppress parasitemia by inhibiting a host target that cannot be mutated by th

2 rway smooth muscle contraction was evaluated by inhibiting acetylcholine (ACh)-induced Pak activation

3 ssed tumor growth in a dose-dependent manner by inhibiting acquisition of the CSC phenotype.

4 usion either by administering intralipids or by inhibiting adipose tissue lipolysis led to failure in

5 sses tumor progression in ovarian carcinomas by inhibiting aerobic glycolysis.

6 ed serum divalent cations eliminate myotonia by inhibiting AfD and NaPIC.

7 ies generation, and matrix protein synthesis by inhibiting AMP-activated protein kinase (AMPK) in ren

8 IGFBP7 abrogates tumors by inhibiting angiogenesis and inducing cancer-specific

9 their orexigenic actions, at least in part, by inhibiting anorexigenic POMC neurons remains unclear.

10 Collectively, our data highlight that, by inhibiting ANT1 and mitochondrial dysfunction, SHP2 o

11 Twist1 also silences Foxa1 promoter by inhibiting AP-1 recruitment.

12 in establishing HIV reservoir in macrophages by inhibiting apoptosis.

13 he chick otic vesicle prevented canal fusion by inhibiting apoptosis.

14 and amiodarone were introduced in the model by inhibiting appropriate ionic channel currents accordi

15 iting formins but, surprisingly, accelerated by inhibiting Arp2/3.

16 nificantly prevented brain damage in SE rats by inhibiting Atg7 and Atg16L1 expression and autophagos

17 Thus, by inhibiting ATGL, HIG2 acts downstream of HIF-1 to seq

18 and suggest that attempts to chemosensitize by inhibiting autophagy could be enhanced by adopting me

19 EC damage can be rescued by inhibiting autophagy formation using 3-methyladenine

20 We demonstrate that NusG slows RNA cleavage by inhibiting backtracking.

21 th survival of M. catarrhalis in human serum by inhibiting bactericidal activity of the complement me

22 breast cancer cells to paclitaxel treatment by inhibiting beta-catenin and PKM2 expression.

23 KIB1 plays an essential role in BR signaling by inhibiting BIN2 through dual mechanisms of blocking s

24 ly improves the quality of newly formed bone by inhibiting BMP2 induced fatty cyst-like structure and

25 pression induced either by erythroferrone or by inhibiting bone morphogenetic protein signaling.

26 s were effective in suppressing tumor growth by inhibiting both AR-induced transcription and mTOR-ind

27 oiesis of Hri(-/-) , eAA, and Atf4(-/-) mice by inhibiting both HRI and mTORC1 signaling.

28 been shown to have immunomodulatory effects by inhibiting Bruton's tyrosine kinase (BTK) and IL-2-in

29 In previous work, by inhibiting C3, we showed that properdin binding to zy

30 tacrolimus causes hypertension predominantly by inhibiting calcineurin directly in cells expressing N

31 pylori gGT enzymatic activity tolerizes DCs by inhibiting cAMP signaling and dampening IL-6 secretio

32 CAMSAP3/Marshalin and modifies its function by inhibiting CAMSAP3/Marshalin-induced bundle formation

33 ulations lowered the glycemic index probably by inhibiting carbohydrate hydrolyzing enzyme activity w

34 ow that CCN1 suppresses hepatocarcinogenesis by inhibiting carcinogen-induced compensatory hepatocyte

35 d GSH/GSSG in three breast cancer cell lines by inhibiting CBS.

36 y exerted potent immune suppressive activity by inhibiting CD8 T cells, enhancing regulatory T cell a

37 lpha and result in immunosurveillance escape by inhibiting CD8+ T-cell recruitment.

38 n, prevents budding within the division site by inhibiting Cdc42 repolarization.

39 nhances BRCA1-PALB2 binding at least in part by inhibiting CDKs.

40 c airways and suppresses airway inflammation by inhibiting cell migration and promoting eosinophil ap

41 s initially recognized as a tumor suppressor by inhibiting cell proliferation via repression of cycli

42 hromatin mutants could be partially restored by inhibiting cep-1/p53, endogenous meiotic double stran

43 imits intracellular cholesterol accumulation by inhibiting cholesterol biosynthesis and by promoting

44 o, suggesting that COL12 represses flowering by inhibiting CO protein function.

45 ehaviour and exchange of matter are prepared by inhibiting coalescence to produce acoustically trappe

46 ts the fusion peptide and blocks viral entry by inhibiting conformational changes in gp120 and gp41 s

47 emical analysis suggests that it neutralizes by inhibiting conformational changes required for entry.

48 s and impairs retrieval of extinction memory by inhibiting consolidation of extinction.

49 on of fatty acid transport into mitochondria by inhibiting CPT using perhexiline resulted in a deplet

50 This suggests that cryoprotectants can act by inhibiting crystallization or recrystallization, but

51 s to people with epilepsy, and is attenuated by inhibiting cyclooxygenase-2 or L-type calcium channel

52 etastatic castrate-resistant prostate cancer by inhibiting CYP17A, an enzyme for testosterone auto-pr

53 ibiting mPFC neurons in VPA-exposed mice, or by inhibiting D2R+ neurons in wild-type mice.

54 tion barrier that promotes podocyte survival by inhibiting dendrin pro-apoptotic function.

55 counteract metabolic insecticide resistance by inhibiting detoxification enzymes or transporters.

56 rferon gamma response and could be prevented by inhibiting development of this response during vaccin

57 ntains HSC long-term reconstitution activity by inhibiting differentiation and cell cycle entry.

58 120, could suppress CRAF-fusion oncogenicity by inhibiting dimer-mediated signaling.

59 ll-molecule-based anticancer agent that acts by inhibiting dimerization of the oncoprotein survivin,

60 , we found that each form of LTF is reversed by inhibiting distinct isoforms of protein kinase M (PKM

61 significantly increased therapeutic efficacy by inhibiting DNA repair and HIF1alpha pathway activatio

62 DNA lesions may compromise genomic integrity by inhibiting DNA replication and inducing mutations in

63 which exerts antileukemic effects, primarily by inhibiting DNA synthesis in proliferating cells.

64 horylation impacts Notch signalling activity by inhibiting DNA-binding of Su(H), potentially affectin

65 protects stalled replication fork stability by inhibiting DNA2 nuclease/WRN helicase-mediated degrad

66 GABAergic neurons facilitate mechanical pain by inhibiting dorsal horn enkephalinergic/GABAergic inte

67 (NAM) ameliorated disease-related phenotypes by inhibiting drusen proteins and inflammatory and compl

68 cts as a negative regulator of PCP signaling by inhibiting Dvl through a novel polyubiquitination mec

69 cells required cAMP production, was reduced by inhibiting dynamin, and was selective for ECVs from k

70 esponsible for a continued ability to arrest by inhibiting E2f activity and by recruiting chromatin-m

71 rane traffic to photoreceptor disc formation by inhibiting ectosome release from the cilium.

72 infection and promoted bacterial persistence by inhibiting effector T cells.

73 onclude that this resistance can be overcome by inhibiting eIF4E phosphorylation with Mnk1/2 or ERK1/

74 thophysiological mechanisms of heart failure by inhibiting either or both NHE isoforms, and drugs use

75 been shown to exert anti-angiogenic effects by inhibiting endothelial cell migration and to display

76 by inducing dorsal Jag1 expression but also by inhibiting endothelin 1 (Edn1) expression in the phar

77 Together, anti-VEGF/VEGFR drugs act in part by inhibiting eNOS, causing vasocontraction, MV collapse

78 Collectively these findings reveal that by inhibiting eNOS, endothelial FcgammaRIIB activation b

79 We tested these signaling changes by inhibiting ERK in the above-mentioned pain models and

80 ver a pathway whereby AGGF1 blocks ER stress by inhibiting ERK1/2 activation and the transcriptional

81 lates endoplasmic reticulum stress signaling by inhibiting ERK1/2 activation, which reduces the level

82 ated the pathogenicity of Th17 cells in part by inhibiting expression of cytokine receptor IL-1R1.

83 Preventing their degradation (by inhibiting fatty acid amide hydrolase) enhanced the e

84 n-independent phenotype that can be reverted by inhibiting FGFR2 signaling.

85 methotrexate during neurulation induces NTDs by inhibiting folate interaction with its uptake systems

86 lability, then animals may adapt accordingly by inhibiting food-seeking responses.

87 NDRG1 attenuates ErbB signaling by inhibiting formation of epidermal growth factor recep

88 ma linear migration was dramatically reduced by inhibiting formins but, surprisingly, accelerated by

89 e host cell membrane, and it is thought that by inhibiting FPPS activity (and therefore cholesterol s

90 ptotic protein, AfBIR1, opposes this process by inhibiting fungal caspase activation and DNA fragment

91 fects the outcome of C. neoformans infection by inhibiting fungal growth and reducing EV stability, w

92 rts its rewarding actions, at least in part, by inhibiting GABAergic input onto substance P (SP) neur

93 n KRAS(12V) mice can be temporarily reverted by inhibiting gamma-aminobutyric acid signaling but not

94 ule inhibitors that attenuated PARP cleavage by inhibiting gamma-H2AX, which in turn inhibited AIF ch

95 iver BVRA protects against hepatic steatosis by inhibiting glycogen synthase kinase 3beta (GSK3beta)

96 suppresses reproduction in birds and mammals by inhibiting GnRH and gonadotropin secretion.

97 nd blocks the regulation of a third gene set by inhibiting GR binding.

98 Repressing the initial ERAD recognition step by inhibiting Grp94 enhances the functional surface expr

99 mutation abrogates the interaction with SOD1 by inhibiting hCCS zinc binding.

100 y UVR protects against its oncogenic effects by inhibiting Hedgehog signaling, whereas dietary vitami

101 gned to suppress angiogenesis and metastasis by inhibiting heparanase and competing for the HS-bindin

102 IL-22 ameliorates liver fibrosis by inhibiting hepatic stellate cells (HSC), and loss of

103 s in M1 macrophages were completely reversed by inhibiting histone deacetylases, which corresponded w

104 Statins lower cholesterol by inhibiting HMG-CoA reductase, the rate-limiting enzym

105 uppress the type I interferon (IFN) response by inhibiting host cell transcription and by proteasomal

106 basis for strategies to control fire blight by inhibiting HsvA activity.

107 vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show consid

108 the hypothesis that miR-H2 promotes latency by inhibiting ICP0 expression, the possibility remains t

109 that miR-195 and CUGBP1 dampen IGF signaling by inhibiting IGF2R translation.

110 prevented IH-induced adverse tumor outcomes by inhibiting IH-induced M2 polarization of TAMs.

111 The anti-TNF-alpha activity was mediated by inhibiting IkappaB kinase phosphorylation, which atte

112 IRI, we speculated that aPC ameliorates IRI by inhibiting inflammasome activation.

113 n and preserving normal parenchymal function by inhibiting inflammation and proliferation.

114 This increase was abrogated by inhibiting inositol trisphosphate-mediated calcium re

115 lock membrane fission when present in excess by inhibiting inter-dynamin interactions.

116 ates the enzyme both directly and indirectly by inhibiting interaction with KPNA2, an RNMT inhibitor.

117 molog repair of meiotic double-strand breaks by inhibiting intersister repair.

118 s against the development of atherosclerosis by inhibiting intestinal cholesterol and triglyceride ab

119 ase 3.Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycl

120 factor- or insulin-induced mTORC1 activation by inhibiting IRS1/AKT signaling.

121 e been focused on targeting it, most notably by inhibiting its AURKB kinase subunit.

122 te that ciA-C2 prevents BoNT/A1 intoxication by inhibiting its binding to neuronal receptor SV2.

123 central metabolism in Listeria monocytogenes by inhibiting its pyruvate carboxylase (LmPC), a biotin-

124 e, we tested the causal inference of miR-182 by inhibiting its renal expression in vivo.

125 raphic studies and enhances BRD4's stability by inhibiting its ubiquitination.

126 tes HBx NEDDylation to enhance HBx stability by inhibiting its ubiquitination.

127 tated IDH1/2 leads to the activation of mTOR by inhibiting KDM4A, an alphaKG-dependent enzyme of the

128 or this distinctive mode of T cell migration by inhibiting key cytoskeletal components and performing

129 y, AgRP signaling contributes to infertility by inhibiting Kiss1 neurons.

130 M1 led to DA cell death, which was prevented by inhibiting L-type Ca(2+) channels.

131 Indeed, slowing NMD by inhibiting late-acting factors triggers UPF1 hyperpho

132 anti-leukemic activity in vitro and in vivo by inhibiting leukemia cell proliferation/viability and

133 that CCDC3 modulates liver lipid metabolism by inhibiting liver de novo lipogenesis as a downstream

134 tributes to the maintenance of HIV-1 latency by inhibiting LTR-driven HIV-1 gene transcription in a n

135 tion, vasopressin stimulates AQP2 exocytosis by inhibiting MAP kinase signaling.

136 umors, regulates MT stability during mitosis by inhibiting MCAK MT depolymerase activity.

137 n, simvastatin may suppress TamR cell growth by inhibiting MCM7 and Rb and subsequently inducing DNA

138 By inhibiting methylation using 5-iodotubercidin, we dem

139 Importantly, by inhibiting methyltransferase activity of CARM1, the e

140 t of cytokines on mouse and human beta-cells by inhibiting MHC class I upregulation.

141 n the behavior of vascular endothelial cells by inhibiting migration.

142 rapeutic effect of OEPCs is improved in vivo by inhibiting miR-17.

143 sion of diabetes-accelerated atherosclerosis by inhibiting mitochondrial fission in endothelial cells

144 ung cancer stem-like cells, which is blocked by inhibiting mitochondrial respiration.

145 r hours, and this phenotype can be prevented by inhibiting mTORC1 or GSK3beta, but not Akt.

146 but stability can be significantly restored by inhibiting mTORC1 or p70S6 kinase (p70S6K), downstrea

147 by low energy could limit protein synthesis by inhibiting mTORC1.

148 ion of PDGF-A/PDGFRalpha blocks NC migration by inhibiting N-cadherin and, consequently, impairing CI

149 icroorganisms can gain a selective advantage by inhibiting nearby competing species(1).

150 th, ATG16L1 maintains the intestinal barrier by inhibiting necroptosis in the epithelium.

151 urons or synapses may potentially be blocked by inhibiting neuraminidases, Gal-3, or MerTK.

152 Interruption of neural communication by inhibiting neuronal firing or by physical cutting sup

153 al effect on hippocampal proliferative cells by inhibiting neuronal proliferation and triggering the

154 on of the dual specificity phosphatase DUSP4 by inhibiting NF-kappaB.

155 inhibited priming of the NLRP3 inflammasome by inhibiting NF-kappaB.

156 5a-induced proliferation of lung fibroblasts by inhibiting NFATc2 signaling via targeting Frizzled re

157 exerts antidepressant-like effects, possibly by inhibiting NLRP3-induced neuro-inflammation in the hi

158 macological evidence that NPY promotes sleep by inhibiting noradrenergic signaling.

159 t Mena(INV) promotes invadopodium maturation by inhibiting normal dephosphorylation of cortactin at t

160 e duct morphogenesis process was interrupted by inhibiting Notch signaling, in an attempt to create a

161 ken together, HBZ suppresses TDP1 expression by inhibiting NRF-1 function in ATL cells.

162 es embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcript

163 ctokinase 1 (PFK-1), which could be reversed by inhibiting O-GlcNAcylation.

164 by directly promoting osteoclast activity or by inhibiting osteoclast signaling intermediaries or thr

165 idneys, which in turn aggravates cyst growth by inhibiting oxidative phosphorylation and stimulating

166 Blocking bacterial metabolism by inhibiting oxidative phosphorylation did not affect W

167 ancreatic beta cells in the diabetic setting by inhibiting oxidative stress and mitochondrial dysfunc

168 ureas are anti-diabetic medications that act by inhibiting pancreatic KATP channels composed of SUR1

169 C-42-dependent NMY-2 in the posterior domain by inhibiting PAR-3 and PAR-6.

170 C1 and that TORC1 can be indirectly targeted by inhibiting Pho84.

171 e that H2S activates CFTR in Xenopus oocytes by inhibiting phosphodiesterase activity and subsequent

172 nhances TRAIL-induced loss of cell viability by inhibiting phosphorylation of Akt and promoting p53 f

173 rome of Lowe (OCRL) deficiencies are reduced by inhibiting PI(3)P production, suggesting PI(3)P kinas

174 ransformation of type II NBs into type I NBs by inhibiting PntP1 function and expression in type II N

175 on, a defect that can be effectively rescued by inhibiting Pol II elongation.

176 GA and poly PA ameliorated poly GA toxicity by inhibiting poly GA aggregation both in vitro and in v

177 Mechanistically, VEC exerts this effect by inhibiting polycomb protein activity on the specific

178 ss and maintained both flesh and pulp colour by inhibiting polyphenol oxidase (PPO) activity of the b

179 play a key role in PM H(+)-ATPase activation by inhibiting PP2C.D family protein phosphatases.

180 CAR proteins are ABA receptors that function by inhibiting PP2Cs to activate SnRK2s, resulting in pho

181 ty of host cells to mount an immune response by inhibiting PPARgamma through secretion of QS molecule

182 y been shown to regulate transmitter release by inhibiting presynaptic Ca(2+) influx.

183 indicate that effects of DMF are facilitated by inhibiting pro-inflammatory NFkappaB, STAT3 and cJUN

184 Hence, by inhibiting production of the protein kinase C-activat

185 ppression of virus-specific B cell responses by inhibiting proliferation of germinal center (GC) B ce

186 nd functionally contributed to EC quiescence by inhibiting proliferation, migration, and sprouting, w

187 3.2 inhibition suppressed GSC growth in part by inhibiting prosurvival AKT/mTOR pathways and stimulat

188 ed UBE2S at Thr 152, enhancing its stability by inhibiting proteasomal degradation.

189 odulate pharmacologically important proteins by inhibiting protein kinases essential for their post-t

190 Ricin A chain can cause toxicity by inhibiting protein synthesis, and ricin B can bind to

191 an counteract the denaturing effects of urea by inhibiting protein-urea preferential interaction.

192 viral activity against the influenza A virus by inhibiting proton conductance of the M2 ion channel.

193 st defense and decreasing pathogen virulence by inhibiting quorum sensing.

194 ntitumor function of T cells can be enhanced by inhibiting reactive oxygen species (ROS) or interveni

195 nd JNK activity under hypoxia were prevented by inhibiting reactive oxygen species generation.

196 Sir2 controls ribosomal DNA (rDNA) silencing by inhibiting recombination and RNA polymerase II-cataly

197 high NaCl diet fenoldopam causes natriuresis by inhibiting renal proximal and distal tubule transport

198 orylase, protein tyrosine phosphatase 1B) or by inhibiting renal sodium-dependent glucose cotransport

199 antibiotic treatment impairs immune function by inhibiting respiratory activity in immune cells.

200 later treatment suppresses viral replication by inhibiting reverse transcriptase, which may restore t

201 muscle cells (SMCs) controls blood pressure by inhibiting RhoA-dependent contractility, providing a

202 ection against radiation-induced skin injury by inhibiting ROS production.

203 amatically reduce flexibility, predominantly by inhibiting rotations of the protein backbone that are

204 e and diversity of fire-dependent ecosystems by inhibiting seed germination or increasing mortality o

205 Improving mitochondrial SIRT3 functions by inhibiting SIRT3 acetylation may offer a new therapeu

206 or supplementation decreased IL-8 secretion by inhibiting Smad 3 phosphorylation.

207 concurrently showed an anti-TGF-beta1 effect by inhibiting Smad3 phosphorylation, resulting in the do

208 hibited therapeutic potential for restenosis by inhibiting SMC accumulation in a rat restenosis model

209 versed by restoring TP53 and RB1 function or by inhibiting SOX2 expression.

210 of the ascending (afferent) auditory system by inhibiting spontaneous activity of the IHCs.

211 recurrent cohesin mutations in cancer, e.g. by inhibiting STAG1, holds the promise for the developme

212 oHSV-1 replication in microglia/macrophages by inhibiting STAT1/3 activity.

213 By inhibiting store-operated calcium entry (SOCE) or vol

214 negatively regulates the type I IFN pathway by inhibiting subcellular redistribution and effective s

215 esistant ovarian cancer cells to PTX and DOX by inhibiting survivin expression.

216 N1; enabling LTM maintenance after retrieval by inhibiting T286 autophosphorylation of alphaCaMKII.

217 It is thought that IDH1 mutants act by inhibiting TET2 to alter DNA methylation, but there a

218 lic effects during progressive kidney injury by inhibiting TGF-beta type 1 receptor.

219 d that GDF-15 suppresses macrophage activity by inhibiting TGF-beta-activated kinase (TAK1) signaling

220 pression of TGF-beta signaling, specifically by inhibiting TGF-beta-activated kinase1 (TAK1) phosphor

221 exogenous hepcidin suppresses HSC activation by inhibiting TGFbeta1-mediated Smad3 phosphorylation vi

222 ple sclerosis facilitate disease progression by inhibiting Th2 immunity and promoting pathogenic Th1

223 genous 2-AG and their actions were prevented by inhibiting the 2-AG-synthesizing enzyme diacylglycero

224 ng calcific deposits, which can be prevented by inhibiting the activated mineralization process.

225 clear factor-kappaB activation predominantly by inhibiting the activation and intrinsic activity of I

226 POP2 also impairs macrophage priming by inhibiting the activation of non-canonical IkappaB ki

227 sterol content in prostate cancer cell lines by inhibiting the activation of sterol regulatory-elemen

228 i) modulates the cell wall integrity pathway by inhibiting the activation of the Slt2 MAP kinase, and

229 our data show that IL-18 may inhibit feeding by inhibiting the activity of BST Type III GABAergic neu

230 molecules or monoclonal antibodies that act by inhibiting the activity of specific proteins that dri

231 S elements impairs initiation of translation by inhibiting the assembly of 80S ribosomes.

232 of Merlin, which suppresses KSR1's function by inhibiting the binding between KSR1 and c-Raf.

233 the microtubule-severing protein Spastin or by inhibiting the C. elegans ninein homolog NOCA-1 in th

234 2PG mechanistically achieves this by inhibiting the Calvin-Benson cycle enzymes triose-pho

235 or planar cell polarity pathways, but rather by inhibiting the canonical pathway, causing both beta-c

236 t CDK-8 most likely promotes I4 neurogenesis by inhibiting the CDK-7/CYH-1 (CDK7/cyclin H) kinase mod

237 The estrogen seems to restore neurogenesis by inhibiting the cell cycle and elevating Ascl1 express

238 ns induce a state of diapause known as dauer by inhibiting the conserved DAF-2 insulin-like signaling

239 romosome segregation defects in cancer cells by inhibiting the correction of erroneous KT-MT interact

240 of articular cartilage development that acts by inhibiting the differentiation of articular cartilage

241 and this protection was completely abolished by inhibiting the dNGIs survival.

242 erts its tumor suppressor function primarily by inhibiting the E2F family of transcription factors th

243 y regulate energy metabolism in mitochondria by inhibiting the electron transfer activity of mitoNEET

244 ome by supplementing its substrate, GSNO, or by inhibiting the enzyme itself.

245 organotin compounds may present an obstacle by inhibiting the enzyme.

246 sed hypertension-induced cardiac hypertrophy by inhibiting the expression of ERK pathway.

247 ies may suppress host kynurenine metabolism, by inhibiting the expression of the metabolizing enzyme,

248 ng that actoxumab neutralizes toxin activity by inhibiting the first step of the intoxication cascade

249 the retrograde signal decreases ACh release by inhibiting the function of pre-synaptic UNC-2/CaV2 ca

250 -induced RORgammat represses cytotoxic genes by inhibiting the functions but not the expression of th

251 e from hypertension-induced cardiac fibrosis by inhibiting the generation of active Pm.

252 dependent on, and most effectively blocked, by inhibiting the HGF/C-Met signaling pathway between en

253 G5 promoted breast cancer cell proliferation by inhibiting the Hippo signaling pathway and increasing

254 Surprisingly, GRHL2 suppressed this process by inhibiting the histone acetyltransferase coactivator

255 This was likely mediated by inhibiting the hypothalamic-pituitary-adrenal axis an

256 ked by preventing direct cellular contact or by inhibiting the ICOS-ICOS-ligand (ICOSL) pathway, sugg

257 hin RV-infected cells and could be abrogated by inhibiting the lysosomal-endosomal degradation pathwa

258 sence of Imp prevents decommissioning partly by inhibiting the mediator complex.

259 gest that MSC-Exo effectively ameliorate EAU by inhibiting the migration of inflammatory cells, indic

260 rial) were blocked by nNOS deletion, but not by inhibiting the mitochondrial Ca(2+) uniporter with Ru

261 tin causes developmental arrest in zebrafish by inhibiting the mitochondrial complex I, but it is unk

262 significantly restricts HIV-1 transcription by inhibiting the NF-kappaB pathway.IMPORTANCE Understan

263 uppressed LPS-induced inflammatory signaling by inhibiting the NFkappaB pathway and expression of EC

264 at PGE2 can block the maturation of IL-1beta by inhibiting the NLRP3 inflammasome in macrophages.

265 at a backup cytokinesis pathway is activated by inhibiting the normal cytokinesis pathway.

266 ose uptake and metabolism in skeletal muscle by inhibiting the nuclear receptor NURR1 and the MEF2 tr

267 ven transgenic mouse models of breast cancer by inhibiting the oncogenic transcriptional activity of

268 steria monocytogenes to various beta-lactams by inhibiting the PASTA kinase PrkA.

269 ting the cell of the amino acid cysteine, or by inhibiting the phospholipid hydroperoxidase glutathio

270 ress activation and expansion of CD4 T cells by inhibiting the phosphorylation of membrane-proximal s

271 ignaling activation suppressed HCC formation by inhibiting the positive feedback loop between YAP/TAZ

272 ose behavioral impairments can be attenuated by inhibiting the Ras-ERK cascade in the adult.

273 ily reduces the steady-state ATPase activity by inhibiting the rate of phosphate release of beta-card

274 ions, which can cause dangerous side effects by inhibiting the receptors that are not involved in the

275 This retrograde regulation functions by inhibiting the recruitment of PPARgamma to the regula

276 Here we challenged rRNA 2'-O-Me globally by inhibiting the rRNA methyl-transferase fibrillarin in

277 pulmonary fibrosis both in vivo and in vitro by inhibiting the TGF-beta signaling pathway.

278 -dependent insulinotropic polypeptide (GIP), by inhibiting their breakdown.

279 2 suppresses replication of X4 HIV-1 strains by inhibiting their entry.

280 clein oligomers in human neuroblastoma cells by inhibiting their interactions with lipid membranes.

281 Accumulation of AEA and 2-AG was achieved by inhibiting their metabolizing enzymes URB597 (a fatty

282 age-derived WNT in intestinal repair in mice by inhibiting their release using a macrophage-restricte

283 reinstatement-an effect that was normalized by inhibiting these corticostriatal afferents immediatel

284 lidomide increased intracellular H2O2 levels by inhibiting thioredoxin reductase (TrxR) in cells expr

285 have now demonstrated that it acts primarily by inhibiting tickover, thereby confirming that tickover

286 ages to suppress their proapoptotic activity by inhibiting TNF and nitric oxide (NO) production.

287 roquinolones; antibacterials that kill cells by inhibiting topoisomerases and inducing double-strande

288 ial nutrient induces non-selective autophagy by inhibiting TORC1, leading to release and recycling of

289 d by Ezh2 and UTX suppresses DPYD expression by inhibiting transcription factor PU.1 binding, leading

290 ed mice suppressed Th17 cell differentiation by inhibiting transcription factor RORgammat.

291 s protein kinase A (PKA) to accelerate aging by inhibiting transcription factors Msn2/4.

292 s in a broad variety of biological processes by inhibiting translation initiation and by destabilizin

293 e activities against human cancer cell lines by inhibiting tubulin polymerization and inducing G2/M c

294 el of vascular endothelial cadherin (VE-Cad) by inhibiting VE-Cad endocytosis.

295 oduct IP5, negatively regulates angiogenesis by inhibiting VEGF expression.

296 ase of both types of EVs and is also reduced by inhibiting VPS4.

297 tional region, which in turn promotes growth by inhibiting Warts.

298 utoxidation, and enhances hemin dissociation by inhibiting water coordination to the Fe(III) atom.

299 xpression, suggesting that Notum acts solely by inhibiting Wg trans-synaptic signaling.

300 howed that Tet3 mediates cell-fate decisions by inhibiting Wnt signaling, partly through promoter dem