ライフサイエンスコーパス: by introducing

1 y 40-fold relative to the intronless control by introducing 11 copies of the more active TTNGATYTG mo

2 resistance and potency of therapeutic siRNAs by introducing 4'-C-methoxy (4'-OMe) as the alpha (C4'al

3 II chaperonin from Thermoplasma acidophilum, by introducing a (His)6-tag within a loop in the alpha s

4 umably reduced renal clearance were obtained by introducing a 1,4-disubstituted 1,2,3-triazole as a p

5 model reproducing the Hajdu Cheney syndrome by introducing a 6955C-->T mutation in the Notch2 locus

6 sed the complexity of the molecular scaffold by introducing a bicyclic core.

7 ere then used to perform blood typing assays by introducing a blood sample.

8 phila Dys, Trio, and Shot were downregulated by introducing a C-terminal truncated mutant DISC1.

9 By introducing a capping step and controlling the reacti

10 rolase with pH-switchable activity, achieved by introducing a catalytic histidine residue at the term

11 mperatures, we herein design a novel pathway by introducing a certain amount of CoO to the supported

12 By introducing a CF3-group at the 4-position of the benz

13 ding a clocked non-volatile spin wave device by introducing a charge-to-spin converter that translate

14 een 5hmU and base J, we also map base J loci by introducing a chemical tagging strategy for the gluco

15 The clv1 phenotype was reverted by introducing a CLV1 promoter-driven CLV1:GFP construct

16 CD4 binding of W69A could be fully restored by introducing a compensatory mutation within layer 2 (S

17 Herein, we address these questions by introducing a conceptual framework, based on the glob

18 ere we show that this enigma can be resolved by introducing a critical scaling form with two divergen

19 By introducing a deep-subwavelength dielectric ridge bet

20 n vivo Reducing Ogg1 O-GlcNAcylation in vivo by introducing a dominant negative O-GlcNAc transferase

21 We circumvent these limitations by introducing a dopamine-gated chloride channel into ra

22 By introducing a flexible component into a molecular bui

23 Thus, by introducing a formal theoretical framework for explor

24 al genomics and structural genomics data and by introducing a functional site interaction fingerprint

25 By introducing a governing force in the assembly process

26 In this study, by introducing a gradient microstructure into 304 austen

27 Here, we addressed the former by introducing a homogeneous quenching resonance energy

28 diac sodium channelopathy that was generated by introducing a human Brugada syndrome-associated SCN5A

29 ets, we augmented the mouse piRNA repertoire by introducing a human meiotic piRNA cluster.

30 We confirmed this by introducing a hydrogen bond-null propofol analogue as

31 with the C-H activation was further resolved by introducing a ligand-directed ortho hydroxylation of

32 , a thermally activated system was developed by introducing a linker between HNPs and gemcitabine.

33 n wild-type mice, increasing task difficulty by introducing a long delay or by optogenetically interf

34 gic and memory can be enhanced significantly by introducing a memristor, a two-terminal device with i

35 etween the alternative optimization criteria by introducing a metric-the marginal xylem tension effic

36 This can be overcome by introducing a minuscule amount of long flexible polym

37 We end by introducing a modeling approach from nutritional ecol

38 Here we couple WGM detection with CE by introducing a modulation scheme to improve detection

39 This hypothesis was tested by introducing a mutation in Arabidopsis diacylglycerol

40 AR's catalytic domain and the guide RNA, and by introducing a mutation in the catalytic domain, the e

41 uorescence interference contrast is achieved by introducing a nanoscopically engineered spacer layer

42 ouse model with a brain-wide deletion of ADK by introducing a Nestin-Cre transgene into a line of con

43 unctional repertoire of such transformations by introducing a new bond-cleaving reaction between N-ox

44 ere, we attempt to ameliorate this situation by introducing a new circular element assembly algorithm

45 the potential to revolutionize biotechnology by introducing a new class of capture molecules with maj

46 Here we address this problem by introducing a new class of planar tetradentate Mn(III

47 We show that this can be accomplished by introducing a new ideal state of matter called a "per

48 he in-plane magnetic field can be eliminated by introducing a new type of perpendicular field-like SO

49 imal cerebral perfusion pressure methodology by introducing a new visualization method.

50 timized a SH-SY5Y cell based tauopathy model by introducing a novel 5-fold Tau mutation eliminating t

51 ne of the critical challenges of advance PRO by introducing a novel electrospun nanofiber-supported t

52 tion of causal variants with high confidence by introducing a novel statistical inquiry to determine

53 We complement the previous work by introducing a novel technoeconomic model of substitut

54 In this study, we circumvent this by introducing a novel treatment protocol that enables t

55 hope for the treatment of many malignancies by introducing a number of novel strategies that exploit

56 oach for silicon-based nanophotonic circuits by introducing a periodic array of silicon strips betwee

57 Here we take steps towards this objective by introducing a probabilistic decoding framework based

58 ration of reactants and the growth time, and by introducing a refresh of the growth solution, the dev

59 heir dynamical glass transition temperatures by introducing a scalar field called "softness," a quant

60 We explored this competition by introducing a second genome into Drosophila melanogas

61 concentrated aqueous electrolyte is proposed by introducing a second lithium salt.

62 hen the open probability is markedly reduced by introducing a second mutation, G1349D.

63 ATP-dependent activity was rescued by introducing a second site gain of function (GOF) muta

64 this work, we eliminated this chemical step by introducing a sensing layer modification using electr

65 served a large enhancement in ECD efficiency by introducing a short ion trapping period at the region

66 a breakthrough insight into the phenomenon, by introducing a simple and natural forecast model that

67 By introducing a simple competition between mechanical a

68 By introducing a simple feedback factor in the diffusive

69 Here, we bridge this gap by introducing a simple model for microbial systems able

70 This study is an attempt of bridging the gap by introducing a simple one-dimensional model for electr

71 of any driver gene mutations, now transform by introducing a single KRAS mutation and form adenosqua

72 We thus modified the effective medium model by introducing a single-parameter descriptor, reff.

73 raction networks in a modifiable environment by introducing a soluble peptide that selectively disrup

74 l the colloid transport in dead-end channels by introducing a solute gradient.

75 cy of inverted polymer light-emitting diodes by introducing a spontaneously formed ripple-shaped nano

76 tients restructure the decision-making frame by introducing a strong emotional dimension.

77 By introducing a suitable nonlocal entropy rate ([Formul

78 que for imaging molecules under confinement, by introducing a system for in situ modification of the

79 We circumvent these difficulties by introducing a technique-cross-trait LD Score regressi

80 nsional photocurrent spectra are interpreted by introducing a theoretical model for the description o

81 el scheme for implementing finite difference by introducing a time-to-space wavelet mapping.

82 take into account the finite sampling issue by introducing a tolerance parameter.

83 Also, by introducing a tunable resolution parameter, MrTADFind

84 sed approaches have revolutionized the field by introducing a unified platform for a simultaneous gen

85 ial molecular spin qubits in the solid state by introducing a unique structural difference, i.e., an

86 to reduce the influence of oxygen vacancies by introducing a valence change doping in the monoclinic

87 g the spatial separation between targets and by introducing a virtual barrier constraining trajectori

88 We further tested this by introducing a water-soluble PIP2 analogue (diC8 -PIP2

89 Here we address this question by introducing a Yap(S112A) knock-in mutation in the end

90 ut 10) of three unrelated types of compounds by introducing active slip planes in structures via diff

91 y a central role in speciation, for example, by introducing adaptive genetic variation.

92 cts can, however, influence folding kinetics by introducing additional local minima that slow diffusi

93 This technique, which works by introducing additional scalar coupling evolution dela

94 we have begun to tackle the challenges of EM by introducing additional steps to the existing method f

95 By introducing Al2 O3 capping, carrier field effect mobi

96 any binary AuHn at P < 300 GPa was overcome by introducing alkali atoms as reductants.

97 of a micro heater is substantially improved by introducing alternative heat-escaping channels into a

98 d variant of the EGFR Ab matuzumab (H425 wt) by introducing amino acid substitutions K326A/E333A (H42

99 imed at reducing the lignin content in jute, by introducing amiRNA based vectors for down-regulation

100 to restore the replication of an MNV mutant by introducing an additional copy of the stem-loop betwe

101 By introducing an additional laser field, we also demons

102 eting specificity, which we further improved by introducing an additional non-PAM-interacting mutatio

103 ability could be realized for the first time by introducing an alkyl linker of optimum length (C4 cha

104 By introducing an amino acid with a terminal alkyne grou

105 By introducing an amphiphilic conjugated polyelectrolyte

106 d a created bulk bandgap in a graphene layer by introducing an asymmetry between the A and B sub-latt

107 used by deletion of tRNA genes, were rescued by introducing an ectopic copy of a single tRNA gene.

108 In this report, by introducing an electronically-tunable acousto-optical

109 This can readily be achieved by introducing an epitope tag.

110 extracellular antibody epitope was generated by introducing an HA (hemagglutinin) tag in the extracel

111 igned a new, inducible gene-targeting system by introducing an in-frame nonsense mutation into the co

112 actor elucidation of toxic metals/metalloids by introducing an index, enrichment factor (EF), in the

113 led A3A expression in the THP1 AML cell line by introducing an inducible A3A gene.

114 ode to an electrochemical metallization mode by introducing an intermediate layer of amorphous carbon

115 This is done by introducing an optical coupling between the laser arr

116 e the drug-binding affinity of a nanocarrier by introducing an optimal drug-binding molecule (DBM) wi

117 This challenge was addressed by introducing an organometallic molecular compound, fer

118 specific activity, prolonging residence time by introducing an osmotic agent, and varying the activit

119 Here we show, by introducing and using minimal recognizable images, th

120 They act as vectors by introducing antigen directly into tumor cells to indu

121 junctions are fabricated in ultrathin MoS(2) by introducing AuCl(3) and benzyl viologen dopants.

122 However, by introducing bacterial products into the host cytosol,

123 We achieve genotyping by introducing barcoded genetic variants into cells as p

124 es in the search of water-soluble indirubins by introducing basic centers.

125 e new avenues to enhance tissue regeneration by introducing bioactive models or constructing patient-

126 the cavities could be simultaneously filled by introducing both cisplatin and triflate concurrently,

127 y helps to address this deficit of solutions by introducing bubble stripping as a novel geochemical e

128 By introducing buffer layers at the front and rear side

129 ctivity, and agonist activity were modulated by introducing bulkier N-substituents, a 2-fluoro substi

130 be fixed predominantly to anti (17a and 17b) by introducing bulky alkyl groups (e.g., propyl groups)

131 nd research to increase C3 crop productivity by introducing C4 photosynthesis(12).

132 lase enzymes to form new carbon-carbon bonds by introducing carbon dioxide gas (CO2) or its hydrated

133 tudy, we deviate from the prevalent approach by introducing catalysis concept in Li/S battery configu

134 This behavior can be modified by introducing CDs into the system to encapsulate the RA

135 face phase transition and magnetic behaviors by introducing chemical strain.

136 G4934V mutation decreased protein stability by introducing clashes with neighboring amino acid resid

137 re we extend the method to quantifying CnClm by introducing CnClm specific response factors (RFs) tha

138 ve this, we alter the bagged-boosting scheme by introducing collaboration between the multi-model's c

139 By introducing colloidal crystal template, a wafer-level

140 ortant roles in signal transduction networks by introducing cooperativity into protein-protein intera

141 e induced switching in the absence of CheY-P by introducing copies of a mutant FliG locked in the clo

142 By introducing copper in the tetrahedral position of the

143 Here, by introducing correlative global sensitivity analysis a

144 e and near-infrared spectrum can be improved by introducing cost-effective, rapid, and high-throughpu

145 state usually seek to decrease chain entropy by introducing cross-links or by replacing glycines.

146 ssions of (131)I further stabilize the depot by introducing crosslinks within the ELP depot over 24h.

147 gineer multilayered wireframe DNA structures by introducing crossover pairs that connect neighboring

148 he catalytic performance is further enhanced by introducing cyano groups to the CoPc molecule.

149 us hemagglutinin (HA) trimer, termed HA3-SS, by introducing cysteine residues into the HA stem to cov

150 This low detection limit is achieved by introducing cyt c in a random medium, enabling multis

151 By introducing D2 in the headspace, hydrogen production

152 exogenous application of gibberellin (GA) or by introducing della quadruple mutants in the nfl backgr

153 The designed behaviour was engineered by introducing destabilising mutations that increased th

154 77 framework and then tuning its environment by introducing different functional groups to the surrou

155 a key role in regulating cellular MTP levels by introducing distinct promoter regions and unique 5'-U

156 By introducing DmJHAMT in E. coli engineered to produce

157 Ps that are representative of each subclass, by introducing dominant negative mutations analogous to

158 Uptake routes were isolated by introducing earthworms with sealed and unsealed mouth

159 nus particles are modified to be amphiphilic by introducing either carboxyl, hydroxyl, or amine moiet

160 signaling and progression of atherosclerosis by introducing endothelial-specific deletion of FGF rece

161 fine the leukocyte recruitment cascade model by introducing endothelium-bound CCN1 as an inflammation

162 We improve on past work by introducing enhancements to automate learning of subs

163 This modulation is accomplished by introducing exogenous nucleic acids such as DNA, mRNA

164 ntermediate 1,2-oxazoline, is often bypassed by introducing extra synthetic steps to avoid the presen

165 We demonstrate the utility of linear donors by introducing fluorescent protein tags in human cells a

166 ITIC-Th1, has been designed and synthesized by introducing fluorine (F) atoms onto the end-capping g

167 neous operation of alternative pathways, but by introducing flux-weighting factors to allow for the v

168 Moreover, the process can be repeated by introducing fresh reagent into the microchamber.

169 C, as assessed in a human melanoma cell line by introducing full-length TET2 and TET2-mutated constru

170 maps, but relax the heatmap grid constraints by introducing gaps between rows and/or columns that are

171 By introducing GCIB sputter to time-of-flight secondary

172 These effects were reversed by introducing GIV but not a GIV mutant that cannot acti

173 anced ambipolar charge transport is achieved by introducing graphene electrodes because of the reduce

174 lso be used as a vaccine master donor strain by introducing hemagglutinin and neuraminidase genes der

175 uctivity of Si/Ge SNW can be further reduced by introducing hierarchical structure to form Si/Ge hier

176 In contrast, sealing was unaffected by introducing hirudin to block fibrin accumulation or a

177 By introducing hybrid random antenna arrays with small m

178 ive particles into various collective states by introducing imbalanced interactions.

179 rophoblast stem (TS)-like cell reprogramming by introducing individual TS cell-specific 'CAG' factors

180 By introducing insertion or substitution of residues wit

181 Interaction by diet was assessed by introducing interaction terms (with SHS) of the indiv

182 sclination lines are stabilized in this work by introducing into a nematic liquid crystal mixture a c

183 Here, we address this question by introducing into alpha-synuclein point mutations that

184 ges of low-flowing microvessels were enabled by introducing inverse variance in conjunction with spec

185 photons in size and characterize the system by introducing joint Wigner tomography.

186 By introducing LBTs in the extracellular region of the a

187 re, we further modified these trimer designs by introducing leucine residues at V3 positions 306 and

188 ustration more in the core than the surface (by introducing loss-of-function events), whereas those a

189 ion can revolutionize information technology by introducing machines capable of recognizing patterns

190 ect with a high Chern number can be realized by introducing magnetization into this system.

191 challenged the carbon neutrality hypothesis by introducing metric indicators to assess the global wa

192 GBAi was engineered by introducing modifications in Galphai that preclude co

193 s loss of sequencing coverage at the termini by introducing modified primers during the targeted ampl

194 of therapeutic T cells in tumor-bearing mice by introducing molecular switches that regulate cell fat

195 able a paradigm shift in modern technologies by introducing multi-functional materials in the semicon

196 ression and solubility are strongly enhanced by introducing multiple negatively charged or asparagine

197 get genes including HIF1a and FCRL3 Finally, by introducing mutations designed to disrupt the OCT2-OC

198 ivity and TCR can be achieved simultaneously by introducing MWCNTs in the Cu matrix, with control of

199 opes and thereby reduce their immunogenicity by introducing N-glycans within the V3 region of BG505 S

200 emonstrate that these issues can be resolved by introducing nanoparticles of nucleants that control s

201 ene nanoribbons can be improved dramatically by introducing nanopores and tuning the Fermi energy.

202 Enhancing the pool boiling performance by introducing nanoscale surface features is an attracti

203 and thermopower (up to 70%) are demonstrated by introducing native defects in Bi2 Te3 films, leading

204 bular and higher-level attentional disorders by introducing new biases to counteract pathological one

205 containing noncanonical amino acids (ncAAs) by introducing orthogonal amber suppressor aminoacyl-tRN

206 totypical CH3NH3PbI3 can be further adjusted by introducing other extrinsic ions.

207 cations, often by manipulating the structure by introducing other lipids with different properties su

208 We show that by introducing overt cues to the illumination, we can fl

209 ctivity of the material was further improved by introducing oxygen vacancies (OVs) that could be achi

210 travel can shape infectious disease dynamics by introducing pathogens into susceptible populations or

211 This effect was attenuated in PC cells by introducing PC-associated SPOP mutants or upon knockd

212 t in power conversion efficiency is achieved by introducing percolation channels of large pores in th

213 be spoof surface plasmon (SSP) out-couplers by introducing periodically arranged SSP scatterers.

214 The method has been demonstrated by introducing phosphoramidite synthons where N-benzylox

215 ng the base compositions of DNA sequences or by introducing phosphorothioate modifications in the DNA

216 can accommodate a wider substrate tolerance by introducing pillararenes as promoters.

217 By introducing POC groups on both the phosphonate and al

218 Disrupting the YscU-YscP interaction by introducing point mutations at the interaction interf

219 By introducing point mutations in the GRK5 RHD-kinase do

220 with high spatial resolution are established by introducing pre-gassed media into the gradient genera

221 Restoring the balance of intestinal flora by introducing probiotics for disease prevention and tre

222 stry, biology, medicine and material science by introducing programmable and responsive behaviour to

223 der Waals heterostructures to the next level by introducing quantum wells (QWs) engineered with one a

224 a possibility for further chemical labeling by introducing reactive spirolactone moieties.

225 mise, we humanized the zebrafish p53 pathway by introducing regulatory and coding sequences of the hu

226 This is achieved by introducing semiconducting ZnO particles into the rel

227 become conditional loss-of-function alleles by introducing sequences encoding the ZF1 tag into endog

228 dic (NtA) motif facilitates RAF dimerization by introducing several interprotomer salt bridges betwee

229 tterns of gene activity control tissue shape by introducing several types of tissue conflict.

230 nsic control over the MA is usually achieved by introducing shape anisotropy or exchange bias from an

231 ce in the strong quantum confinement regime, by introducing short ligands (octanoic acid and octylami

232 We extend these studies here by introducing single-backbone H-bond impairing modifica

233 By introducing single-point ADPKD pathogenic mutations i

234 developed an improvement of the 3DCC method by introducing singular value decomposition (SVD) for pr

235 nst invading phages and conjugative plasmids by introducing site-specific double-stranded breaks in t

236 ures for breeding offspring were established by introducing six adults per sex into each of 4 (low de

237 uce tortuous thermal paths (i.e. labyrinths) by introducing slits to control the impact of the unobst

238 OS ranges from partially to entirely blocked by introducing slits, s = 95, 195, 245, 295 and 395 nm.

239 perimentally evaluated the proposed CR model by introducing small molecules to, and measuring the tem

240 ance to in vivo Treg biology was established by introducing some of the subtle Foxp3 mutations into t

241 ral correlation structure of store locations by introducing space-time random effects in an intrinsic

242 We solve these problems by introducing sparse trees and coalescence records as t

243 double layer graphene nanoribbon is achieved by introducing spatio-temporal modulation of system prop

244 al (2D) MoS2 semiconductors can be modulated by introducing specific defects.

245 of a new series of compounds (1-16) obtained by introducing specific structural changes at key points

246 3 NH3 PbI3 perovskite is chemically modified by introducing SrCl2 in the precursor solution.

247 MCS centers have improved patient management by introducing standardized driveline protocols, leading

248 lts highlight the gains in accuracy achieved by introducing statistical models into fusion detection,

249 ween the recognition sites can be controlled by introducing steric "speed bumps" or electrostatically

250 By introducing steric constraints into molecular compoun

251 This can be achieved by introducing stimuli-cleavable linkages into the scaff

252 We demonstrate that by introducing stochastic fluctuations in one of the cou

253 terized functions of the FATC domain of Tel1 by introducing substitution or truncation mutations.

254 the basal plane of monolayer 2H-MoS2 for HER by introducing sulphur (S) vacancies and strain.

255 By introducing targeted activation to enhance tumor sele

256 By introducing targeted combinations of changes in multi

257 By introducing the 5-8-5 defects into graphene, the frac

258 Remarkably though, by introducing the action of topological enzymes such as

259 eated transgenic mice carrying this mutation by introducing the alanine to threonine mutation at posi

260 del, TgFD9; Ikbkap(Delta20/flox) was created by introducing the complete human IKBKAP transgene with

261 Here, we try to tackle this challenge by introducing the concept of a reprogrammable hologram

262 xposome to children's health risk assessment by introducing the concept of Lifestage Exposome Snapsho

263 Here, we developed an innovative approach by introducing the concept that mitochondrial targeting

264 Here, we generated rCl-13(GPC/VGKS) by introducing the corresponding revertant mutations K46

265 We provide evidence that they are induced by introducing the cosmid St4A10lsp, as part of ReDirect

266 Lowering the DNA replication initiation rate by introducing the dnaA(Sx) allele or by overexpressing

267 view of protein-DNA interaction was obtained by introducing the fluorescence donor 6-CNTrp in RRM1 at

268 em of GO (gene ontology) sparsity is tackled by introducing the homolog knowledge as independent homo

269 d mouse model (GEMM) for BRCA1-deficient MBC by introducing the MET proto-oncogene into a BRCA1-assoc

270 ffusion-controlled in standard immunoassays, by introducing the microsphere-based assay into well-mix

271 Specifically, increasing channel activity by introducing the mutation K1250A or pretreating with t

272 t coherence time of superconducting circuits by introducing the naturally long-lived spin degree of f

273 By introducing the nuclear-localized cameleon Nup-YC2.1

274 nd physicochemical properties were optimized by introducing the para-chloro and aminopyrrolidine grou

275 dation of vte6 mutants was partially rescued by introducing the phytol kinase mutation vte5.

276 By introducing the piezo-phototronic effect, the perform

277 eir performances can be effectively enhanced by introducing the piezo-phototronic effect.

278 nhance the ferroelectric photovoltaic effect by introducing the polarization-dependent interfacial co

279 circadian rhythmicity and sleep homeostasis by introducing the polymorphism into mice and assessing

280 transmitted terahertz field can be observed by introducing the resonances of the meta-atoms.

281 ated SIVsmE660 strain without animal passage by introducing the same amino acid capsid substitutions.

282 rus (ZIKV) VLP production level was enhanced by introducing the same F108A mutation into the ZIKV env

283 Here, we address this by introducing the software COMPASS, which, by combining

284 t for engineering novel, high-yielding crops by introducing the trait into C(3) backgrounds.

285 By introducing the use of low-resolution MS/MS DIA, we d

286 ccurring substitutions in BTX autoresistance by introducing them into rat Nav1.4 muscle Na(+) channel

287 mutation resulted in lower miR-16 expression by introducing three novel splicing sites instead of the

288 a vascular progenitor state expressing CD34, by introducing transcription factors OCT4, SOX2, KLF4 an

289 a nonlinear flat lens into a magnifying lens by introducing transformation optics into the nonlinear

290 By introducing transmission geometry (tg) LAESI and inco

291 c moduli relieve bend and splay deformations by introducing twist deformations.

292 Here, by introducing two amino acid substitutions into the bet

293 This is achieved by introducing two orthogonally polarized reference puls

294 By introducing two sulfur atoms to a single carboxylate

295 By introducing two tools--semiclassical phase-space quan

296 ocalization of the cognate mRNA were rescued by introducing untagged mRNA coding for mutant non-local

297 R radioligands for imaging and therapy of BC by introducing valid preclinical in vitro and in vivo mo

298 laments on the lateral membrane organization by introducing various phase-separated lipid mono- and b

299 By introducing well-patterned micropillar array texture

300 climate change would be greatly facilitated by introducing wider genetic diversity for heat resilien