ライフサイエンスコーパス: by itself

1 cTBS with 150 pulses (cTBS150) has no effect by itself.

2 tor that has no cocaine-like abuse potential by itself.

3 by a subsequent protocol that has no effect by itself.

4 D supports NA assembly, the TMD was examined by itself.

5 Turbulent shear does not boost settlement by itself.

6 random clusters for systems of whey protein by itself.

7 triction of HIV-1 than either function would by itself.

8 n, protein binding of the drug, and the drug by itself.

9 beta toxicity, without inducing any toxicity by itself.

10 atic function, whereas maize ISA1 was active by itself.

11 ing was observed in the case of CBPQT(2(*+)) by itself.

12 ceiving stimulation too weak to induce L-LTP by itself.

13 on under conditions where CCL27 is monomeric by itself.

14 biguous to support visual object recognition by itself.

15 n solution, whereas h16 is relatively stable by itself.

16 llular 5-HT concentrations, relative to D-22 by itself.

17 ffect with AG1478 but also induced apoptosis by itself.

18 not show any effect on origami conformation by itself.

19 cyclization/demethylation reaction sequence by itself.

20 retroviruses and produce cell transformation by itself.

21 te kidney injury-like neutrophil dysfunction by itself.

22 nched conformation in response to pH changes by itself.

23 ystem allowed monitoring the effects of Hog1 by itself.

24 not account for the reduction in firing rate by itself.

25 m this function, exogenous phosphatidic acid by itself (300 pM) increases GTP binding and enhances PL

26 bition of olfactory sensory neurons elicited by itself a full range of olfactory behaviors from attra

27 tion could be detected between E1p and E2pCD by itself, a domain-induced interaction was identified o

28 D reorientation may be important, it is not, by itself, a sufficient condition for G stimulation.

29 g that reduction of miR-H6 expression is not by itself able to alter the establishment of latency for

30 Thus, B can by itself account for the development of behavior under

31 ic agents in peripheral nerve tissues cannot by itself account for their associated neurotoxicity.

32 Although it had no effect by itself, acetaminophen greatly increased the reflex ir

33 P by itself acted as a contaminant when studying the respo

34 expressing either full-length Hsf or HsfBD1 by itself adhered at high levels, while bacteria express

35 igh levels, while bacteria expressing HsfBD2 by itself adhered at low levels.

36 his is the first demonstration that nicotine by itself affects responses in the human retina.

37 oma therapy, but is likely to be ineffective by itself against advanced cancer.

38 , however, treatment with doxorubicin, which by itself also induced autophagy, markedly reduced the e

39 (Met-818) and GluN2A(Leu-824), that does not by itself alter ethanol sensitivity, whereas a previousl

40 that the S segment of the same virus confers by itself an attenuated phenotype to wild-type SBV, as i

41 e-threatening condition and it should not be by itself an indication for surgical treatment.

42 ed to assess the effect of this polymorphism by itself and alongside variants in CYP2C19 on cardiovas

43 d synthesis of these architectures is an art by itself and as such is worth being reviewed.

44 We present here crystal structures of SlyA by itself and bound to a high-affinity DNA operator sequ

45 the N-terminal coiled-coil domain of ANGPTL4 by itself and full-length ANGPTL4 both bound with simila

46 report that resveratrol elevated cAMP levels by itself and further potentiated a forskolin-induced in

47 ngly, CXCL10 expression could be upregulated by itself and IL-17 in inflammatory cells.

48 ne Top1 inhibitor in phase 1 clinical trial, by itself and in combination with the cell-cycle checkpo

49 In contrast, the Th2 cytokine IL-4, by itself and in combination with the TLR2/1 ligand, ind

50 lly, PDE8A regulates testosterone production by itself and in concert with additional IBMX-sensitive

51 We demonstrate that HBx, both by itself and in the context of HBV replication, affecte

52 D23580, and thereby prevents superinfection by itself and other phage that uses the same O-antigen c

53 Sourdough fermentation by itself and with chestnut flour reduced volume of loav

54 C38 is also highly soluble by itself, and it lends its high intrinsic solubility to

55 e for engineering custom specificities, both by itself as a new scaffold alone and in hybrid construc

56 It can also work by itself as a standalone genome browser.

57 chain can efficiently reach the cell surface by itself as an IgE-binding receptor in the absence of a

58 Thus, 11-cis retinal by itself, as well as other agents that form photosensit

59 tic lesions across multiple data sets and is by itself associated with disease recurrence and disease

60 Fmn2 by itself associates very poorly to filament barbed ends

61 ut they suggest that such a system would not by itself be sufficient to explain imitation at any age.

62 Our results also show that ScMre11 by itself binds to DSB ends, then promotes end bridging

63 he cholinergic interneurons was not aversive by itself) blocked cocaine conditioning in freely moving

64 athway not only stimulates the TRPC6 channel by itself but also sensitizes the channels to diacylglyc

65 FliM does not multimerize efficiently by itself but does so in the presence of FliG.

66 lavour complexes were reported with limonene by itself but were observed when added in binary flavour

67 insufficient to activate rhomboid expression by itself, but does so in conjunction with additional fa

68 The probe is almost nonemissive by itself, but it gives turn-on fluorescence in the pres

69 did not affect endocrine cell proliferation by itself, but synergistically enhanced proliferation wh

70 ry to generate the calyx DAP, whereas I(NaR) by itself can generate a prominent DAP.

71 a normal infection to determine whether ICP0 by itself can interfere with interferon or IRF-3-depende

72 his model is not caffeine, although caffeine by itself can show moderate protection.

73 Our data demonstrate that glucotoxicity by itself can trigger cardiac dysfunction and that a glu

74 d, the efficacy of interactive communication by itself cannot be established.

75 trans-Golgi network, although the EXS domain by itself cannot mediate Pi export.

76 of filament assembly in a confined space is by itself capable of yielding the remodeling behavior ob

77 (O-GlcNAc) transferase (OGT), an enzyme that by itself catalyses the addition of O-GlcNAc onto serine

78 response to this treatment, but not rPrP(c) by itself, cause increased chemotaxis of both uninfected

79 Down-regulation of FoxO1 using siRNA by itself caused up-regulation of claudin-5 expression a

80 lular metabolome showed that FLT3 inhibition by itself causes profound alterations in central carbon

81 By itself, CCR8 stimulation was unable to rescue Tregs f

82 By itself, CER will not solve the tension that exists be

83 chemical success without clinical success is by itself clinically important and older women and men c

84 er must be able to persist with the resource by itself, coexistence becomes consistently less likely

85 ing and Treg depletion, as neither mechanism by itself could fully rescue the exhaustion phenotype.

86 und that the C-terminal region (Pgamma63-87) by itself could not be displaced but that transducin cou

87 omic structure of the relevant Nup58 segment by itself, demonstrating that it forms a twofold symmetr

88 study, we show that the TLR7/8 agonist CL097 by itself did not induce NADPH oxidase activation in hum

89 utation of the identified AKT substrate site by itself did not perturb B cell development.

90 Inactivation of Pot1a by itself did not stimulate endometrial carcinogenesis,

91 Notably, however, chloride loading by itself did not trigger full ictal events, even with a

92 03 deletion mutant, although fully competent by itself, did not efficiently infect mice when transmit

93 Foveal ablation, by itself, did not produce systematic alterations in eit

94 s that the loss of the vacuolar Ca(2+) pumps by itself does not cause a catastrophic defect in ion ho

95 y of the "healthy" surrounding tissue, which by itself does not generate seizures, but can support se

96 virion at acidic pH, and that furin cleavage by itself does not induce any major conformational chang

97 ng T cells is slow, occurring over 96 h, but by itself does not result in a significant upregulation

98 High SYK expression by itself drives the constitutive activation observed in

99 albumin level is a risk factor for infection by itself (e.g., by being associated with a higher free

100 Whereas desipramine did not by itself elicit circulating HSPCs, it increased G-CSF-t

101 expression of the truncated PR8 NS1 protein by itself enhances the inhibition of the activation of I

102 demonstrate that this truncated NS1 protein by itself enhances this suppression, demonstrating that

103 a and a relatively small sample size cannot, by itself, establish a causal connection between smoking

104 nitiate autoimmune or inflammatory pathology by itself, even though every immune cell population had

105 self-assembling sequence was not immunogenic by itself, even when delivered in CFA.

106 se of the overall abundance of TonEBP/OREBP, by itself, eventually raises its effective level in the

107 esponded to a gain of function: whereas CTA1 by itself exhibited minimal in vitro activity at 37 degr

108 on 57 (previously known; P = 1 x 10(-1,355)) by itself explained 15.2% of the total phenotypic varian

109 to this surge in adoption, but income growth by itself explains most of the increase.

110 However, CeA stimulation by itself failed to support behavioral self-stimulation

111 This peptide, by itself, failed to generate any current when transfect

112 ilarly to previous studies, we found that M1 by itself fails to form virus-like-particles (VLPs).

113 induced Treg induction because Flt3L/antigen by itself fails to induce Treg.

114 However, this model by itself fails to predict the magnitude of enzymes' rat

115 t capable of inducing long-term memory (LTM) by itself, flies develop an LTM.

116 /-) MEFs, and neither receptor was essential by itself for the antiviral response to UK rotavirus.

117 s the full-length (M1) AQP4 isoform does not by itself form OAPs but can coassemble with M23 in OAPs

118 intermediate, capable of emitting dim light by itself, formed from the reaction between guanines of

119 n the other hand, sequencing of the library, by itself, gives information that is mostly unrelated to

120 development, respectively, whereas nutrition by itself had a small effect size of 0.09.

121 The Ang1 inhibitor by itself had little noticeable effect on the tumor vasc

122 ficantly by application of pooledhIgG, which by itself had no significant effect.

123 Although CFA, by itself, had little effect on spatial memory, morphine

124 By itself, HAMNO treatment creates DNA replication stres

125 t extended to aqueous solution because water by itself has field fluctuations that are too large and

126 uct maytansine, a microtubule inhibitor that by itself has limited clinical activity and high systemi

127 Interestingly, the deacetylase core of Sirt1 by itself has no catalytic activity.

128 ir efficacy, even though one of the two mAbs by itself has no effect on neutralization.

129 Previously, we reported that KS-WNK1 by itself has no effect on ROMK1 but antagonizes L-WNK1-

130 This particular combined approach by itself has not previously been shown to be efficaciou

131 he accessory alpha-helix (amino acids 27-48) by itself has the capacity to replace the C-terminus of

132 Self-blood pressure monitoring, by itself, has been shown to be an effective tool in pre

133 The R145W RCM mutation by itself, however, does not impact LDA.

134 areG(0) approximately -2 kcal/mol), whereas, by itself, hydrogenation of N2(g) is highly endergonic.

135 By itself, ICOS-L blockade reduced accumulation of intra

136 Nes-S cannot form filaments by itself in cytoplasmic intermediate filament-free SW13

137 The ROR score was significantly prognostic by itself in years 5 to 10.

138 o not respond to an appetitive US of sucrose by itself, in contrast to their robust response to an av

139 In transfected cells, DSCAM by itself, in the absence of DCC, is capable of mediatin

140 2, although unable to associate with heparin by itself, increased the association rate of the binding

141 Nor did CeA stimulation by itself induce any aversive state that motivated escap

142 Within this subset, only NeuroD4 could by itself induce neuronal reprogramming in both mouse an

143 geted PKCdelta-dF(1)F(0) facilitator peptide by itself induced the PKCdelta-dF(1)F(0) co-immunoprecip

144 The HFP by itself induces vesicle fusion and is a useful model s

145 DksA and is only half the size of DksA, TraR by itself inhibits transcription as strongly as DksA and

146 d evidence for abrupt climate changes but is by itself insufficient for quantitative reconstruction o

147 We found that the beta1-subunit can by itself interact with TP and that this association can

148 the protein folds reversibly and reassembles by itself into the knotted dimeric conformation without

149 that the PAR posttranslational modification by itself is a high affinity ligand for XRCC1, requiring

150 GA by itself is a mild antimicrobial and has a pro-oxidant

151 In mouse xenograft studies, alpha-MT by itself is able to reduce the growth of the ER-positiv

152 rucial to determine whether cocaine exposure by itself is an etiological factor and, if so, to determ

153 llectively, the data indicate that the toxin by itself is capable of crossing epithelial barriers.

154 not only miR-22 inhibits BMP-7/6, but miR-22 by itself is induced by BMP-7/6.

155 reduced antigen burden in the chronic phase by itself is insufficient for rescue of exhausted CD8(+)

156 ce or diminution of humoral immune responses by itself is insufficient to drive the R5-to-X4 switch a

157 results suggest that sperm hyperpolarization by itself is key to enabling mice sperm to undergo the a

158 However, absence of light by itself is not a sufficient environmental signal for e

159 r, we demonstrate that N-acetylhomotaurinate by itself is not an active psychotropic molecule.

160 elevations in serum EPO, indicating that EPO by itself is not directly involved in Hamp1 regulation.

161 Therefore, myeloid replacement by itself is not likely to be effective as a therapeutic

162 This effect by itself is not sufficient, however, to fully explain t

163 PTA by itself is only one of several indices of severity of

164 Temperature by itself is probably not a major determinant in regulat

165 This GAF domain by itself is sufficient for covalent attachment.

166 ved in signal transduction, and this subunit by itself is sufficient to couple extracellular stimuli

167 monstrated here that over-expression of CIB1 by itself is sufficient to drive localisation of SK1 to

168 We show that increased expression of ERG by itself is sufficient to induce expansion of MEPs in f

169 The proapoptotic Bcl-2 protein Bax by itself is sufficient to initiate apoptosis in almost

170 able to function are necessary, and neither by itself is sufficient, for Cx37 to mediate growth supp

171 TPP1/POT1a and RPA indicates that TPP1/POT1a by itself is unlikely to exclude RPA.

172 data suggest that C9orf72 loss-of-function, by itself, is insufficient to cause motor neuron disease

173 activity of Wnt/beta-catenin signaling that, by itself, is known to cause a nearly identical phenotyp

174 r, indicates that multisite phosphorylation, by itself, is less effective at creating switchlike resp

175 one of the three subdomains of VAR2CSA DBL3x by itself, is the major contributor toward CSA binding.

176 ecursor GA12, although biologically inactive by itself, is the major mobile GA signal over long dista

177 silonRI alpha-chain reached the cell surface by itself, it formed a ligand-binding receptor that stab

178 each of these three features is challenging by itself, it is remarkable that the orthogonal QPM supe

179 Although N17 is highly soluble by itself, it lowers the saturation concentration of sol

180 ugh PGE2 does not induce IL-23p19 expression by itself, it synergizes with both extra- and intracellu

181 The R1 subunit has no endonuclease activity by itself; it strongly stimulates REase activity when in

182 Administered by itself, KWAR23 is inert, but given in combination wit

183 Notably, Red1, by itself, lacked DNA-pairing ability; however, it poten

184 uvate exchanges affect cell redox state, and by itself lactate is a ROS generator.

185 This stress response does not by itself lead to liver injury.

186 By itself, loss of NuRD activity is not sufficient for t

187 Addition of a CaP coating to SBAE Ti by itself may affect key events of in vitro osteogenesis

188 PMV infection by itself modulated expression of putative genes functio

189 Consequently, PE represents by itself more than half of all plastic wastes.

190 addition to markedly reducing spine density by itself, morphine amplified the effect of higher level

191 ltidrug transporters, Reversan was not toxic by itself nor did it increase the toxicity of chemothera

192 In contrast, neither maternal separation by itself nor the rearing-by-drug interaction was signif

193 s of mice is not sufficient to promote ccRCC by itself, nor does it enhance HIF1alphaM3 oncogenesis w

194 fore, potentiometry as a single technique is by itself not sufficient to obtain information about the

195 amate receptor subunit, which decreased p(r) by itself, occluded the interference with postsynaptic N

196 may encroach on surrounding natural forests by itself occurred in China.

197 ne containing peptide building block, which, by itself, only forms trimers and tetramers that do not

198 ed significantly slowed inactivation, either by itself or after equimolar coexpression with the wild-

199 Serum cystatin C, by itself or as a part of an estimated GFR, was a signif

200 The code can be run by itself or as part of a larger simulator.

201 estored when the C terminus was co-expressed by itself or fused to the C terminus of the beta-subunit

202 We also examined whether ANK3, by itself or in a panel with other top CFG-prioritized g

203 A null mutation in COX25 by itself or in combination with other COX mutations doe

204 expression of oncogenic K-Ras(G12V), either by itself or in combination with RAF dimer promoting inh

205 ted analog peptide NY-ESO-1 157-165V, either by itself or in combination with the pan-DR epitope NY-E

206 niger) did not cause cell wall creep, either by itself or in combination with XEG.

207 e multifactorial uses as a bioactive peptide by itself or in tissue engineering.

208 We introduced ShMKS2 by itself or together with ShMKS1 to Arabidopsis (Arabid

209 action of the E1o-h with 2-oxoglutarate (OG) by itself or when assembled from individual components i

210 f infections than those with either disorder by itself (P < .0001).

211 c-statistic: 0.56 vs. 0.56) although neither by itself performed well.

212 Thus, CTCF by itself plays a central role in mediating the dichotom

213 Therefore, alum by itself poorly induces Mo-DCs to migrate to draining L

214 8, was also in the expression signature and, by itself, predicted poor clinical outcome in one cohort

215 al defeat, although not producing depression by itself, produced in 50% of rats reduced threshold for

216 DDK phosphorylation of Mcm2-7 does not by itself promote separation of the double hexamer, but

217 multiple sites in a telomere array does not, by itself, promote formation of a more energetically sta

218 th chondroitinase ABC (denoted ChABC) could, by itself, promote the plasticity of tracts that were sp

219 ecules per envelope glycoprotein complex and by itself promoted HR1 exposure.

220 Thus, neither dPCR platform by itself provides metrologically traceable estimates of

221 The N-terminal RRM domain by itself provides the editing activity of ORRM3.

222 des being a physically meaningful phenomenon by itself, provides a resolution.

223 By itself, Rad50 is a relatively inefficient ATPase, but

224 deled by a single differential equation, can by itself rapidly clear small initial numbers of pneumoc

225 Although overexpression of MYCN by itself rarely caused bone marrow metastasis, combinin

226 As expected, the vaccine by itself reduced viral loads but had no acquisition eff

227 both drugs combined, relative to either drug by itself, reduced loss aversion in the absence of an ef

228 s to acute electric footshock stress did not by itself reinstate drug-seeking behavior but potentiate

229 We also found that Msx1 by itself represses transcription from this proximal Bmp

230 ich is more effective than use of either one by itself, requires that any resistant virus have mutati

231 TCAH exposure by itself resulted in a decline in mitochondrial respira

232 posure to traumatic stress during deployment by itself resulted in longitudinal increases in SKA2 met

233 c profiles of rILYd4 in mice, we showed that by itself rILYd4 does not adversely mediate in vivo hemo

234 By itself, scar dechanneling rendered noninducibility in

235 However, the prolonged administration of AZA by itself seems to increase HN rate compared with standa

236 creased tendency of STN burst discharges may by itself serve as a direct cause of parkinsonian locomo

237 level of PD-1 expression by T cells does not by itself serve as a reliable marker for immune exhausti

238 The methyltransferase activity of MLL1, by itself severely compromised, is stimulated by the thr

239 f nine residues in the autolysis loop, which by itself shifts the specificity of the enzyme from fibr

240 Age by itself should not be an absolute contraindication aga

241 Procedure volume by itself should not be used as a proxy measure for surg

242 MP3 rs522616 A was detected, and this allele by itself showed greater promoter activity than the G al

243 we find that although the RIM2 C(2)B domain by itself significantly decreased Ca(2+)-channel inactiv

244 By itself, Sle2 does not induce any autoimmune pathology

245 Inhibition of AR activity by itself stimulated AKR1C3 expression.

246 The antibacterial triclocarban (TCC) by itself stimulates AroB expression only slightly, but

247 s to integrate (from now on called uDNA) can by itself successfully produce infectious offspring viri

248 optoXR photostimulation in nucleus accumbens by itself sufficed to drive conditioned place preference

249 An EMB grade >/=2R is not by itself sufficient as a basis for clinical decisions o

250 domain that bound most avidly to CHMP4B was by itself sufficient to inhibit the function of ALIX in

251 model-adding a point output nonlinearity-is by itself sufficient to produce cells that are disparity

252 t prolongs action potential duration, is not by itself sufficient to produce EADs.

253 iosynthetic apical sorting of p75 but is not by itself sufficient to reroute a protein to the apical

254 ance of eIF4E interaction with eIF4G was not by itself sufficient to sustain global rates of protein

255 ase mutant-virus-infected cells and does not by itself support the hypothesis that ICP27 stabilizes A

256 The Hv channel VSD by itself supports H(+) flux.

257 We demonstrate that FOXP1 by itself supports HSPC and leukemic cell growth, thus m

258 Given that (i) B29 administration by itself suppressed disease, (ii) our findings were mad

259 By itself, t-POC was a very poor quality resource compar

260 ants, RecA4142 can bind other DNA substrates by itself that are normally degraded by the SbcCD nuclea

261 esting that it represents an epigenetic mark by itself that may regulate chromatin structure and tran

262 ation of dynein in live cells indicates that by itself the triple BICD2-N-dynein-dynactin complex is

263 not a significant driver of increment width by itself, the combined effect of tidal movement and tem

264 By itself, the D836A mutation does not confer a phenotyp

265 esent a sort of individual "cardioprinting." By itself, the diagnosis of LVNC does not coincide with

266 Unreactive by itself, the Mo-dimethyl catecholate analogue reduces

267 ugh each of these mutant modifiers is benign by itself, they interact to affect heart development whe

268 By itself, this mechanism only weakly amplifies signalin

269 is in a similar manner as TEL-AML1 silencing by itself; this silencing was also shown to be Dicer-dep

270 uggesting that Prdm9 variation does not seem by itself to contribute to equine hybrid sterility.

271 bodies CR6261, F10, and others is sufficient by itself to elicit antibodies with similarly broad anti

272 ispensable for Chk1 activity or insufficient by itself to exert an effect on Chk1 activity.

273 "walking" mechanism, by which vSET acts all by itself to globally methylate host H3K27, which is acc

274 is a scaling factor necessary and sufficient by itself to induce and maintain secretory cell architec

275 se data suggest that LIT, while insufficient by itself to lead to OB, works synergistically with aspi

276 ed the conformations of integrin in solution by itself to localize the membrane and the talin-binding

277 e by inducing hypothermia, a condition shown by itself to reduce the thrombolytic and proteolytic pro

278 Although not sufficient by itself to rescue mutant CFTR therapeutically, the ele

279 man cancer, MYC deregulation is insufficient by itself to transform cells.

280 main of Ets1 is required, but not sufficient by itself, to block ASC formation.

281 -retention domain (KTEL), and is sufficient, by itself, to promote the acquisition of invasive and me

282 oyl-2-oleoyl phosphatidylethanolamine, which by itself undergoes the lamellar-to-inverse hexagonal ph

283 lk and As in organic, none of these elements by itself was able to discriminate between organic and c

284 Resistin by itself was able to induce acute kidney injury-like ne

285 Moreover, recombinant galectin-10 by itself was able to suppress T cell proliferation.

286 ts own lacked any reinforcement value: laser by itself was never self-stimulated, not even by the sam

287 However, ORE1 accumulation by itself was not sufficient to cause saul1 phenotypes,

288 Although in concentrated solutions TRN-SR2 by itself was predominantly present as a dimer, the TRN-

289 at the level of this non-catalytic component by itself was sufficient to change the levels of total A

290 Forced expression of SMAD7 in beta cells by itself was sufficient to promote beta-cell proliferat

291 physiologic hypoxia, high GLUT-1 expression, by itself, was insufficient to ensure high (18)F-FDG upt

292 which suggests that JAK2 inhibitor therapy, by itself, was not curative in this MPN model.

293 he formation of calcium phosphate polymorphs by itself, when bound to immobilized type I collagen and

294 Standardization by itself will not be enough--also required are advances

295 It is weakly emissive by itself with its fluorescence quenched by electron tra

296 Ets-1(331-440) bound the P5-EBS by itself with low affinity (K(d)=136 nM).

297 100% or serve as an excellent anode material by itself with stable cyclability and consistently high

298 SM gives both electrical and optical signals by itself without applying an external power source.

299 We conclude that serological analysis by itself would greatly underestimate the true memory of

300 old' dose of AMPH in healthy subjects, which by itself would not induce clinically significant increa