ライフサイエンスコーパス: by modifying

1 of uncertainty reported in previous studies by modifying (1) the shape of the typical flight path, (

2 al nanostructured electrodes were fabricated by modifying 100 mum gold wires with 17 nm gold nanopart

3 hesized Trex2 participates in DNA DSB repair by modifying 3' ends.

4 omain protein that regulates gene expression by modifying 3D chromatin structure.

5 Here, we extend this capability by modifying a 40 x 18 mum(2) cantilever into one termin

6 We created this tool by modifying a commercial 8-channel pipet using machined

7 dosage disrupts cortical circuit development by modifying a critical molecular signaling pathway via

8 constriction in this homopentameric protein by modifying a critical pore residue one subunit at a ti

9 ulatory range of the Rnt1p control elements, by modifying a critical region for enzyme binding to its

10 as a transcriptional activator or repressor by modifying a diverse set of substrates.

11 The biosensor was fabricated by modifying a gold electrode with gold nanoparticles (A

12 ctronic structure of the organoboron species by modifying a heteroaromatic component in the conjugate

13 By modifying a highly conserved adenosine A2503 in 23S r

14 giocarcinoma cell line CC-SW-1 was developed by modifying a NeutrAvidin-biotin system.

15 By modifying a previous assay to use recombinant tubulin

16 The heart failure model is derived by modifying a previously validated electrophysiology mo

17 We developed new mathematical models by modifying a proposed stochastic birth process to inco

18 ) for the non-enzymatic detection of glucose by modifying a screen-printed carbon electrode with coba

19 By modifying a spider silk to be conductive and transduc

20 conducting solid electrolyte is demonstrated by modifying a well-known negative photoresist, SU-8, wi

21 affinity chromatography method was developed by modifying a zonal elution method.

22 olling internal structure of cell aggregates by modifying aggregation kinetics is a potential strateg

23 By modifying amino-groups, glycation interferes with fol

24 either by gating reward prediction errors or by modifying an implicit representation of motor compete

25 and not fully recognized evolutionary roles by modifying and biasing natural selection.

26 recipes, both by creating new algorithms and by modifying and recombining successful recipes develope

27 We demonstrate that by modifying array synthesis procedures to accommodate t

28 ted using self-assembled monolayer principle by modifying Au electrode with cysteamine (Cys) and immo

29 ression of surface IgM but not IgD BCRs, and by modifying basal calcium levels.

30 ert a cumulative effect on platelet function by modifying basic platelet parameters, such as mean pla

31 The response aims to reduce this imbalance by modifying behavior and intrinsic body systems to dire

32 logists predicted that parental care evolves by modifying behavioural precursors in the asocial ances

33 By modifying beta-catenin activity, we force cells withi

34 er to determine the content of consciousness by modifying both taste perception and later action.

35 ccounted for most of the correction achieved by modifying both the domain and the interface.

36 us (five out of six) can impact hypertension by modifying BP and renal phenotypes.

37 band structure can be continuously tailored by modifying cadmium content or temperature.

38 a normoxic or hypoxic environment, possibly by modifying calcium metabolism.

39 and which respond to environmental variables by modifying Callocation belowground, are needed for bet

40 By modifying candidate SNPs in transgenic flies, we show

41 sor was developed to detect anticancer drugs by modifying carbon paste electrodes with glutathione-s-

42 ar-related morbidity and mortality, possibly by modifying cardiac structure and function, yet firm ev

43 DR by promoting inappropriate S phase entry, by modifying cellular DDR factors directly, or by uninte

44 s epigenetically regulate cellular processes by modifying chromatin and influencing gene expression.

45 xpression, a master driver of cell stemness, by modifying chromatin architecture at the Sox2 promoter

46 PRC2) plays an essential role in development by modifying chromatin but what this means at a cellular

47 b protein family and represses transcription by modifying chromatin organization at specific promoter

48 ive role in Pol I transcription, potentially by modifying chromatin structure in the rDNA repeats.

49 ssory proteins that antagonize transcription by modifying chromatin structure.

50 G) proteins mediate heritable gene silencing by modifying chromatin structure.

51 ugh these problems can be partially overcome by modifying classical theories for colloidal interactio

52 oercion of human primed embryonic stem cells by modifying culture conditions or through transgenic mo

53 t, we standardized the size of cardiospheres by modifying culture conditions.

54 ediate cellular responses to the environment by modifying cysteines of signaling proteins.

55 is a negative modulator of HSC self-renewal by modifying cytokine responses and expression of genes

56 Reducing lung cancer risk by modifying diet is highly desirable.

57 to adapt to similar environmental challenges by modifying different sets of genes.

58 the transcriptional activity of the receptor by modifying DNA and recruiting essential transcription

59 lymorphism (MTHFR 677C>T) may influence risk by modifying DNA methylation.

60 or ultrasensitive and selective DA detection by modifying DNA-aptamers on a multiple-parallel-connect

61 ns to tune physical properties in thin films by modifying electronic structure.

62 al applications can bridge these categories, by modifying energy crops properties, or analysing circu

63 nterest in combating these diseases not only by modifying energy intake and lifestyle factors, but al

64 receptor-induced apoptosis of infected cells by modifying FADD in an irreversible manner.

65 ization of selectivity for the fungal enzyme by modifying functional groups that interact with struct

66 g cell functions can be modulated via opsins by modifying fundamental nonlinear optical properties of

67 ormance, and might offer therapeutic benefit by modifying fundamental pathophysiology in pulmonary va

68 mple, tumors can prevent T cell infiltration by modifying gene expression in the endothelial cells an

69 er, the in vivo application of this approach by modifying genomic loci is uncommon, partly due to its

70 er with Herpes Simplex Virus (HSV-1) vectors by modifying glycoprotein C (gC) to replace the heparin

71 lase that regulates hepatic lipid metabolism by modifying histones and transcription factors.

72 Microbiota regulate intestinal physiology by modifying host gene expression along the length of th

73 shows the possibility of reducing water uses by modifying households' behavior to encourage healthier

74 e spin energy-levels in a single quantum dot by modifying how spins sense magnetic field.

75 PS derivatives (AMPDs); they are synthesized by modifying hydrophilic PSs with a variety of hydrophob

76 t opportunities for breast cancer prevention by modifying individual estrogen metabolism profiles thr

77 osition of liver regulates insulin signaling by modifying insulin receptor translocation into membran

78 ng protein (IGFBP)-1 influences fetal growth by modifying insulin-like growth factor-I (IGF-I) bioava

79 through plant-mediated indirect effects, or by modifying interactions among species.

80 Cell fate can be reprogrammed by modifying intrinsic and extrinsic cues.

81 Increasing the density of Env by modifying it in various ways has met with limited suc

82 an energy storage function are demonstrated by modifying its counter electrode with a poly (vinylide

83 e possibility to adjust the pH of the sample by modifying its exposure time with the membrane by vary

84 nding to Miro1 halts mitochondrial transport by modifying its interaction with kinesin-1 whereas mito

85 ular levels of polyP regulates Top1 activity by modifying its polyphosphorylation status.

86 As with most organisms, MTB adapts to stress by modifying its transcriptional profile.

87 By modifying KinTek Explorer software, we present a new

88 amined ways of reducing their reactogenicity by modifying lipid A, the endotoxic part of LPS, through

89 tion and loss generated leaf shape diversity by modifying local growth patterns during organogenesis.

90 We propose that by modifying localized cation balance and pH, these tran

91 ia drives variable host type I IFN responses by modifying LPS in a subset of bacteria.

92 ins could promote catastrophe events in part by modifying microtubule tip structures.

93 available package, miRDeep-P, was developed by modifying miRDeep, which is based on a probabilistic

94 Genomic variants can alter miRNA regulation by modifying miRNA target sites, and multiple human dise

95 Gaucher disease and other genetic disorders by modifying molecular chaperone and protein degradation

96 tive effect on human colorectal cancer cells by modifying molecules involved in either cell cycle arr

97 coordinates movements and maintains balance by modifying motor commands as a function of sensory-mot

98 se data provide new insights into how MAP65, by modifying MT mechanical properties, may regulate the

99 evade pneumococcal conjugate vaccines (PCV) by modifying, mutating, or deleting vaccine-serotype cap

100 ity is intensifying fungal disease dispersal by modifying natural environments and thus creating new

101 plex metabolic pathways have been engineered by modifying natural pathways and establishing de novo p

102 ly mitigates the endowment effect indirectly by modifying negative affective responses in the context

103 rtificially generating these activity states by modifying neuronal activity increases the reliability

104 s maintain heritable states of transcription by modifying nucleosomal histones or remodeling chromati

105 matin remodelers regulate chromatin dynamics by modifying nucleosome positions and occupancy.

106 nyltransferases that modulate Notch activity by modifying O-fucose residues on epidermal growth facto

107 easy modulation of the catalytic performance by modifying one of their building blocks and the develo

108 orating some forms of vestibular dysfunction by modifying ongoing primary vestibular input.

109 indirectly through aerosol formation and/or by modifying oxidant levels and thus changing the atmosp

110 ly inhibits the NF-kappaB activation pathway by modifying p65 and inhibiting IkappaBalpha kinase acti

111 ay data with a molecular interaction network by modifying per-gene differential expression P-values s

112 s to raise the yield potential of C(3) crops by modifying photosynthesis to the more efficient C(4) p

113 By modifying PKC phosphorylation at the AL site, cocaine

114 Here, we created a unique Polg animal model, by modifying polg within the critical and highly conserv

115 Four p-type polymers were synthesized by modifying poly(bisdodecylquaterthiophene) (PQT12) to

116 By modifying polymer compositions and cross-linking reag

117 ed library of over 50 compounds was prepared by modifying positions 5, 7, and 8 of the parent compoun

118 g the mammalian face to be remodelled simply by modifying postnatal growth.

119 By modifying pressure during UHPLC separation, it was po

120 s and policy options for reducing CVD burden by modifying preventable risk factors.

121 flats influenced shorebird foraging directly by modifying prey availability.

122 transcription in early development, possibly by modifying proteins important to maintain the ESC tran

123 possibility to modulate their stoichiometry by modifying reaction conditions.

124 tune the regiochemistry to a desired result by modifying reaction conditions.

125 Furthermore, solely by modifying reactionware architecture, reaction outcome

126 tly in the membrane-interacting loops and/or by modifying residues away from the membrane-interacting

127 ment in vitro and in vivo, can be controlled by modifying, respectively, the hydrogel's elastic modul

128 NAs (sRNAs) control aspects of this coupling by modifying ribosome access or inducing degradation of

129 Inside the plant cell it suppresses immunity by modifying RNA-binding proteins including the glycine-

130 By modifying rules that govern activity-dependent synapt

131 at temperature influences evolutionary rates by modifying selective pressures rather than through its

132 g a unique strategy for treating the disease by modifying signal transduction pathways with small-mol

133 ring injection is a risk that can be reduced by modifying skin prep and injection practices.

134 fluence plant growth and community structure by modifying soil biota and nutrients.

135 change drivers can indirectly affect plants by modifying species interactions.

136 hat augment exposure to abiotic extremes and by modifying species interactions.

137 g the change to trophic interactions induced by modifying species.

138 e theory that antidepressants may indeed act by modifying specific neural dysfunctions correlated to

139 y of the urea-fluoride complexes are tunable by modifying substituents on the urea receptor.

140 colonization and dispersal can be inhibited by modifying surface chemistry.

141 Astrocytes interact dynamically with neurons by modifying synaptic activity and plasticity.

142 ped to enable fine-tuning of EWNS properties by modifying synthesis parameters.

143 that (1) saccadic adaptation can be induced by modifying target object size and (2) this gradual cha

144 (99m)Tc-TCP-1 was generated by modifying TCP-1 with succinimidyl-6-hydrazino-nicotin

145 revents DNA damage-induced neurodegeneration by modifying the acetylation pattern of the tumor suppre

146 ay impact the outcome of catalytic reactions by modifying the acidities of the metal hydrides formed.

147 us may function to sort actomyosin processes by modifying the actin track affinity for specific myosi

148 ctly by generating DNA damage but indirectly by modifying the activities of DNA repair and genome sta

149 version of insulin molecules into aggregates by modifying the aggregation pathway.

150 rations in the shell and core solutions, and by modifying the AMC size.

151 as enhanced 5-fold by codon optimization and by modifying the amino acid sequence to be identical to

152 0 phosphorylation alters calcium sensitivity by modifying the AQP0-CaM interaction interface, particu

153 ectional wave pattern, which can be diverted by modifying the arrangement of the spinners within the

154 2 cells on top of the MEAs has been achieved by modifying the array with a poly(dimethylsiloxane) cha

155 ss other types of synapses might be obtained by modifying the artificial peptide neurotransmitter to

156 Leucettine L41 does not act by modifying the autophagic flux of vesicles.

157 We can reproduce the exhaustion signature by modifying the balance of persistent stimulation of T-

158 distal dendrites of striatal output neurons by modifying the balance of two calcium sources, NMDARs

159 By modifying the beta-strand "stalk" of BLV1H12 with seq

160 large increase in granule cell excitability by modifying the biophysical properties of Kv4 channels

161 y from carbonate reservoirs can be increased by modifying the brine composition injected during recov

162 s of the reactants and products, rather than by modifying the catalyst.

163 induced volume transition could be modulated by modifying the chromatin compaction state and remodeli

164 ese effectors, NSD3, regulates transcription by modifying the chromatin microenvironment at Brd4 targ

165 ss in amphiphile membranes can be controlled by modifying the competition of long-range and short-ran

166 ctive strategy to constrain the change of pH by modifying the composition of electroporation buffer.

167 e mechanical conditions are often controlled by modifying the composition of the environment, separat

168 n the reaction were qualitatively identified by modifying the conditions to either promote the format

169 uantity of a signal amplification reagent or by modifying the configuration of the paper-based microf

170 the ability of DnaB to interact with primase by modifying the conformation of the NTD of DnaB.

171 atory and inhibitory neurons can be achieved by modifying the connectivity patterns between both type

172 cally regulate DNA damage signaling pathways by modifying the core histones as well as chromatin modi

173 ectric dipole moment which could be adjusted by modifying the crystal symmetry of the microwave absor

174 s may alter the ecological role of herbivory by modifying the defense strategies of plants and thus t

175 domains can enhance the Seebeck coefficient by modifying the density of states and/or providing type

176 reward-based learning mechanisms as well as by modifying the description of the decision problem, bu

177 the plasmonic resonance of the nanostructure by modifying the dielectric constant of the metal.

178 gulate a symmetry transition event in plants by modifying the direction of auxin transport.

179 d are shown to be dynamically reconfigurable by modifying the direction or polarization of impinging

180 ected from restriction endonuclease cleavage by modifying the DNA using a DNA methyltransferase.

181 We then show that this bias can be corrected by modifying the downward momentum flux to the surface.

182 -selective adenovirus vectors can be created by modifying the efficiency with which the viral DNA pol

183 By modifying the EIL peptide, we constructed peptide var

184 e developed several biosensors configuration by modifying the electrochemical sensor transducer: (a)

185 iosensor performance can be further improved by modifying the electrode surface to enhance electronic

186 ach for engineering drought stress tolerance by modifying the endogenous trehalase activity in Arabid

187 dynamics or induce alternative binding modes by modifying the ensemble of accessible conformations.

188 ts on the knowledge that animals communicate by modifying the environment in which they live, providi

189 intracellular molecular clock mechanisms or by modifying the environment of neurogenic niches, with

190 nd the previous features can all be reversed by modifying the environment.

191 By modifying the ester group and thus its susceptibility

192 utionary outcome of social interactions; and by modifying the evolutionarily stable expression of beh

193 d nutrient spatial patterns only indirectly, by modifying the extent of surface water/groundwater exc

194 increasing repulsion or reducing attraction by modifying the fluid medium or by using additives.

195 behavior following noxious heat stimulation by modifying the forward-to-reversal behavioral transiti

196 s to obtain follow-up CT scans were computed by modifying the frequency of CT scans with the hazard o

197 orms--Affymetrix Human Exon and Gene 1.0 ST--by modifying the fRMA probe-level model and extending th

198 the efficient secretion of S-layer proteins by modifying the general secretory pathway of B. anthrac

199 phenotype and spectrum of Trp53 mutant mice by modifying the genetic mechanisms underlying tumorigen

200 reduce the metabolic consequences of obesity by modifying the gut microbiota and preventing metabolic

201 By modifying the HA matrix, Tnfip6 (TNF-alpha-induced pr

202 Transcutaneous DNA immunization by modifying the hair follicle cycle may hold a great pr

203 tor cells, thus amplifying liver damage, and by modifying the hepatic cellular and cytokine milieu dr

204 on conduction through the transmembrane pore by modifying the His37-water proton exchange equilibria

205 rm carbon accumulation in tropical peatlands by modifying the Holocene Peat Model (HPM), which has be

206 orms may contribute to the development of AD by modifying the homeostasis of ApoE physiological partn

207 balance between mechanisms may be modulated by modifying the immunogen used to induce the antibodies

208 rts and numerous attempts to improve outcome by modifying the inflammatory response.

209 ity to fine-tune the target tissue responses by modifying the intracellular trafficking and secretory

210 tive error of the second eye can be improved by modifying the IOL power to correct up to 50% of the e

211 arying nanoparticle sizes (5, 13, 23 nm) and by modifying the Kd of the bioreceptor using wild-type a

212 her by concentrating CO(2) around Rubisco or by modifying the kinetic properties of Rubisco.

213 cancer effect, we have developed 35 peptides by modifying the lead.

214 Motor fluctuations may be managed by modifying the levodopa dosing regimen or by adding se

215 rectly (by forming NPQ sites) or indirectly (by modifying the LHCII membrane environment).

216 The efficacy of the conjugate was optimized by modifying the linker structure, relative binding orie

217 n control the emission from quantum emitters by modifying the local density of optical states via the

218 be used to finely tune the lattice symmetry by modifying the local distortions, i.e., octahedral bon

219 ble niches to study and direct cell function by modifying the local hydrogel environment.

220 guidelines for correcting problematic sites by modifying the metal-binding environment and/or redefi

221 sible to engineer the intestinal environment by modifying the microbiota community structure or funct

222 cts that this rate constant may be increased by modifying the molecule in a manner that decreases the

223 apted to an obligate intracellular lifestyle by modifying the morphology and content of their cells.

224 is unclear whether they exert their effects by modifying the myocardial redox state.

225 The nanofiller dispersion can be improved by modifying the nanomaterial (NM) surface or predispers

226 The density of the arrays can be controlled by modifying the nanoparticle functionality, pH of the s

227 By modifying the nanoparticle surface coverage, which ca

228 obtain highly specific inhibitors of MMP-14 by modifying the natural non-specific broad MMP inhibito

229 AK1-binding proteins 2 and 3 (TAB2 and TAB3) by modifying the Npl4 zinc finger domain through S-adeno

230 ch to solve this often unappreciated problem by modifying the nucleotide sequences of the target mRNA

231 erage pumping frequency from 0.83 to 3.33 Hz by modifying the on-chip valves to minimize adhesion bet

232 The enhancements were achieved by modifying the original procedure in three ways: First

233 mmunoglobulin G (IgG) antibody avidity assay by modifying the Ortho 3.0 HCV enzyme-linked immunoassay

234 sensor that responds to a specific input(s) by modifying the output of a cognate regulator.

235 acid (TBOA) or dissipating the driving force by modifying the patch-pipette solution.

236 Finally, by modifying the payoffs to satisfy two novel conditions

237 Five different ligands were prepared by modifying the peripheral thioether moiety with naphth

238 treatment of OTS increased the MB adsorption by modifying the physicochemical properties of OTS and s

239 tracts evidently inhibited biofilm formation by modifying the physicochemical properties of the cell

240 as to improve the original vaccine candidate by modifying the PIV5 vector or by modifying the RSV F a

241 e have fabricated a label free DNA biosensor by modifying the platinum wire with electrochemically sy

242 trolling the types of crosslinks rather than by modifying the polymer itself.

243 er the patient-specific survival probability by modifying the populations of circulating tumour cells

244 ply alters the temporal order of replication by modifying the rate of origin firing within various Ig

245 polymer with different charge distributions by modifying the ratio of anionic and neutral end groups

246 tected benzylamine derivatives were achieved by modifying the reaction conditions, which presented an

247 ructural determination of GPCRs has advanced by modifying the receptors with stabilizing mutations, i

248 MAGE oligos for (i) tuning translation rates by modifying the ribosomal binding site, (ii) generating

249 thesized through lead chemistry optimization by modifying the rings A-C and the core structure in fur

250 d RSV F expression by codon optimization and by modifying the RSV F amino acid sequence to conform to

251 ne candidate by modifying the PIV5 vector or by modifying the RSV F antigen.

252 roteins in aqueous solutions can be directed by modifying the salt concentration.

253 L concentration and whole-body fat oxidation by modifying the saturation index of circulating and tis

254 By modifying the secondary building units (SBUs) of MOLs

255 Further, by modifying the sensor use from traditional to dynamic

256 an be modified to analyze other types of RNA by modifying the steps for RNA purification as appropria

257 process and a single anneal process, simply by modifying the structural design and/or the anneal tem

258 This is achieved by modifying the structural design of the SiGe strips, w

259 We aimed to create mPGES-1 inhibitors by modifying the structure of NSAIDs by replacing the ca

260 By modifying the structure of the carbanion nucleophile,

261 By modifying the substituents on the 7-amino-5-thio-thia

262 icoid receptor agonists (DAGRs) was achieved by modifying the substitution at C3 from (S)-3-hydroxy t

263 By modifying the substitution pattern on the alkynone su

264 o reduce both organic and biological fouling by modifying the surface of commercially available poly(

265 to the transferrin receptor of cancer cells by modifying the surface of the liposome with transferri

266 rane on solid surface at low pH was improved by modifying the surface with a conductive substrate con

267 An amine layer was produced next by modifying the surface with EDAC/NHS followed by react

268 The fibrils are built by modifying the synthetic peptide fragment correspondin

269 study how mycotoxin levels may be influenced by modifying the technological parameters of both whole

270 th Turing's original model, which we explain by modifying the theory to include heterogeneity.

271 The proposed method is realized by modifying the TurboFold II algorithm for prediction o

272 enzymes (DUBs) can regulate these processes by modifying the ubiquitination status of target protein

273 h direct interactions or indirectly, perhaps by modifying the underlying microtubule lattice.

274 ceptibility variants for Parkinson's disease by modifying the underlying point mutations in the alpha

275 milies were shown by the grape varieties and by modifying the vine growing practices.

276 trate tunability of the negative speed zones by modifying the viscosity of the suspending medium.

277 A binary search is performed by modifying the weight applied to the flux of the bioma

278 This was accomplished by modifying the widely used technique of stable isotope

279 the bovine papillomavirus E1 and E2 proteins by modifying their DNA binding activity.

280 eria survive harmful environmental stressors by modifying their outer membrane.

281 to numerous endogenous and exogenous signals by modifying their proliferation and differentiation.

282 RNAs regulate hundreds of target transcripts by modifying their stability and translation on a broad

283 avior of these acetal groups can be adjusted by modifying their stereoelectronic and steric propertie

284 he animals studied affect disease phenotypes by modifying their susceptibility, presentation and resp

285 and circuit motifs but form unique networks by modifying these cardinal units.

286 By modifying these features, we could impart Spot 42 reg

287 Twenty-nine mutants were generated by modifying these three sites, individually or in combi

288 hat effects of food deprivation are mediated by modifying this protein.

289 We simulated the data successfully by modifying those parameters of a clock model that are

290 lso affect tissue movement and morphogenesis by modifying tissue tension in surrounding cells.

291 nfiguration of the sensing elements - either by modifying toggle switches and gene networks, or by pr

292 By modifying total canopy leaf area, its vertical profil

293 the low-pH performance of the YGP1 promoter by modifying transcription factor binding sites in its u

294 bda acted as a unique immunomodulatory agent by modifying transcriptional and non-translational neutr

295 A may indirectly alter the biotic conditions by modifying trophic interactions.

296 ercise slows the trajectory of normal ageing by modifying vascular and metabolic risk factors and/or

297 ake of cancer therapeutics at the tumor site by modifying vascular permeability in the tumor to incre

298 By modifying ventricular relaxation properties and the i

299 ures facilitate forgiveness and reduce anger by modifying victims' perceptions of their transgressors

300 uted to controlled release after consumption by modifying vitamin bioaccessibility.