ライフサイエンスコーパス: by relieving

1 ng domain (CNBD) facilitates channel opening by relieving a tonic inhibition exerted by the CNBD.

2 LMO7 activates MRTFs by relieving actin-mediated inhibition in a manner that

3 By relieving acyl-CoA-mediated feedback inhibition of li

4 ion in the early phase of liver regeneration by relieving Akt1/mTOR complex 1 signaling (and thus eIF

5 , Eco1 promotes sister DNA entrapment partly by relieving an antiestablishment activity associated wi

6 tes ERK activity in immature granulosa cells by relieving an inhibition imposed by a 100-kDa phosphot

7 dings suggest that Gib2 promotes cAMP levels by relieving an inhibitory function of Ras1 on Cac1 in t

8 mprove functional status and quality of life by relieving anxiety and dyspnea.

9 src homology 3 domain-containing Cb variants by relieving autoinhibition and thus define an alternati

10 ns and show that they increase BRAF activity by relieving autoinhibition and/or enhancing PS binding,

11 es the in vitro DNA binding activity of ETV4 by relieving autoinhibition.

12 suggest that cdc42p and bud6p activate for3p by relieving autoinhibition.

13 ding with C1b alone activates classical PKDs by relieving C1-mediated inhibition.

14 easing CysC would facilitate Abeta clearance by relieving CatB inhibition.

15 sidases enhance enzymatic biomass conversion by relieving cellobiose inhibition of endoglucanases and

16 CTT mitigates infarct risk in pediatric SCA by relieving cerebral metabolic stress at patient- and t

17 nhancers are believed to stimulate promoters by relieving chromatin-mediated repression.

18 he Nox structure promotes oxidase activation by relieving constraint induced by regulatory components

19 Inhibitors of ET-1, by relieving constriction, may significantly lessen the

20 n (PCI) aims to increase coronary blood flow by relieving epicardial obstruction.

21 DEPTOR overexpression suppresses S6K1 but, by relieving feedback inhibition from mTORC1 to PI3K sig

22 nsulin/IGFs regulate beta cell proliferation by relieving Foxo1 inhibition of Pdx1 expression in a su

23 TP53 loss activated G55-dependent secretion by relieving G55 and myosin IIA from miR-34a-dependent s

24 um, which augmented the heparin acceleration by relieving Gla domain inhibition as previously shown f

25 s6 is essential for XmyoD induction and acts by relieving Groucho-mediated repression of gene express

26 By relieving inhibition at the IC, we show that an initi

27 uggesting a model in which Smo activates Gli by relieving inhibition by SuFu.

28 s formin-dependent capping of the barbed end by relieving inhibition of elongation by FRL1-FH1FH2, mD

29 ion where it decreases the cellular response by relieving inhibition of the sAHP.

30 Smac, a pro-apoptotic protein that functions by relieving inhibitor-of-apoptosis protein (IAP)-mediat

31 homodimers, receptor function can be rescued by relieving intracellular C-terminal domain-dependent i

32 een shown to regulate its catalytic activity by relieving intramolecular autoinhibitory interactions.

33 hought to activate these descending pathways by relieving intrinsic GABAergic inhibition of PAG neuro

34 een commensals and coumarins promotes growth by relieving iron starvation.

35 nt models propose that LIS1 activates dynein by relieving its autoinhibited form.

36 tivates the transcriptional function of LAP1 by relieving its autoinhibited state effected by intramo

37 The chemokine may alter tumor behavior by relieving its growth factor dependency and by promoti

38 sarcoplasmic reticulum calcium pump (SERCA) by relieving its inhibition by PLN.

39 uman HCC contributed to SETDB1 up-regulation by relieving its post-transcriptional regulation.

40 ted current at active CA3 recurrent synapses by relieving magnesium block.

41 litated by two complementary mechanisms: (i) by relieving membrane tension, possibly by TANGO1-mediat

42 rapeutic potential against ccRCC development by relieving metabolic stress.

43 arget genes and Myc functions as an oncogene by relieving Mnt-mediated repression.

44 is globally important forest carbon (C) sink by relieving N limitation.

45 and higher repetitive firing rates, possibly by relieving Na(+) channel inactivation, and thus contri

46 ctivates the epithelial Na(+) channel (ENaC) by relieving Na(+) self-inhibition.

47 model in which protons modulate ENaC gating by relieving Na(+) self-inhibition.

48 , has the potential to aid smoking cessation by relieving nicotine withdrawal symptoms and reducing t

49 as reversed by concomitant Parkin deficiency by relieving obstructions in receptor-mediated (Parkin-i

50 ciently restored colonic epithelial barriers by relieving oxidative stress and promoting epithelium m

51 resistance and acute lung infection in mice by relieving PdtaS/R-mediated repression of isonitrile c

52 dependent manner it induces the QS hierarchy by relieving PraR-mediated repression of rhiR and raiR.

53 gen (N) should enhance herbivore performance by relieving protein limitation, increasing herbivorous

54 tors, spermine potentiates kainate receptors by relieving proton inhibition of the receptor.

55 atched (Ptc) elicits intracellular signaling by relieving Ptc-mediated inhibition of the transmembran

56 ZEB1 drives exocytotic vesicular trafficking by relieving Rab6A, Rab8A, and guanine nucleotide exchan

57 s the formation of the anion depletion layer by relieving rapid Zn(2+) ions exhaustion and strengthen

58 hesis and that it activates psbA translation by relieving repression by an HCF136-dependent assembly

59 Cdc7-Dbf4 promotes NDT80 transcription by relieving repression mediated by a complex of Sum1, R

60 y a critical role in transcriptional control by relieving repressive effects of chromatin, and yet ho

61 to increase the excitability of nociceptors by relieving resting slow inactivation of tetrodotoxin-r

62 By relieving REV-ERBalpha-dependent repression, FBXW7 pr

63 RNA transcript, and enhances its translation by relieving ribosome stalling.

64 AB7A serves as a switch, promoting mitophagy by relieving Rubicon inhibition and favoring Pacer activ

65 sulin-like growth factor I-dependent manner, by relieving S6K1-dependent negative regulation of insul

66 r and that Yki promotes normal tissue growth by relieving Sd-mediated default repression.

67 nascent lid that drives RP assembly, in part by relieving steric clash with the base.

68 icarbonate can further increase sAC activity by relieving substrate inhibition.

69 s) and boosters may increase enzyme activity by relieving substrate/product inhibition.

70 DNA topoisomerase II modulates DNA topology by relieving supercoil stress and by unknotting or decat

71 umor regression directly but also indirectly by relieving suppressive signals that restrict potent an

72 l (RBC) transfusion may improve QOL after MI by relieving symptoms and/or increasing functional capac

73 her, BTKis enhance bsAb-induced cytotoxicity by relieving T cells of immunosuppressive restraints imp

74 ffective LV remodeling approach to reduce MR by relieving tethering.

75 l, in cyanobacteria improves carbon fixation by relieving the "sink" limitation of photosynthesis.

76 ed the possibility that Utp14 activates Dhr1 by relieving the autoinhibition of the loop within the R

77 aluable chemicals from lignin at high yields by relieving the burden of constitutively expressing tox

78 suggest that external Zn(2+) activates ENaC by relieving the channel from Na(+) self-inhibition, and

79 The second input is provided by relieving the COL7A1 promoter from chicken ovalbumin

80 s promote mitosis and cell cycle progression by relieving the E2F7/E2F8-mediated inhibition is unknow

81 rinosome-inducing cues, ASB11 is upregulated by relieving the H3K9me3/HP1alpha-mediated transcription

82 and USF enhanced Ets-1 DNA binding in vitro by relieving the influence of an autoinhibitory domain i

83 naptotagmin-1 activates fast release, likely by relieving the inhibition caused by Complexins and coo

84 golic acid, decreases alpha-synuclein levels by relieving the inhibition exerted on alpha-synuclein p

85 y on the Bcl-2 family members Bax and/or Bak by relieving the inhibition imposed by antiapoptotic mem

86 tein levels by Cdc5 promotes FEAR activation by relieving the inhibition on Clb2-Cdk1, the kinase for

87 te cancer disrupts this regulatory mechanism by relieving the inhibitory effects of C2 and WW on Hect

88 CaBP4 increases Cav1.4 channel availability by relieving the inhibitory effects of the ICDI domain o

89 fully treat and prevent rheumatoid arthritis by relieving the main symptoms and also by restoring the

90 phosphorylation stimulates DNA end resection by relieving the negative effect that Rad9 exerts over t

91 tion extended the T-cell-receptor repertoire by relieving the requirement for a charged residue in CD

92 ables sensitive and rapid signaling response by relieving the speed-sensitivity trade-off, which can

93 The EMT1-201 mutant suppressed prp2-1 by relieving the splicing block at high temperature.

94 nable the binding of 4(R)-hydroxy-2-oxoacids by relieving the steric hindrance between the 5-methyl g

95 tor Twist1 in inducing mesenchymal migration by relieving the suppression of NEDD9 and DOCK3 by the m

96 periaqueductal gray (PAG) descending pathway by relieving the tonic inhibition of projection neurons

97 rmed that adenosine receptor activation acts by relieving the translational repressive effect of the

98 -PD-1 invigorates subdominant TCD8 responses by relieving their lysis-dependent suppression by immuno

99 t contributes to the full activation of ISGs by relieving their repression by EMSY and BRCA2.

100 tein stability can be significantly improved by relieving these interactions.

101 vel and that these agents sensitize MM cells by relieving this block.

102 By relieving this restraint, CTLA-4-blocking antibodies

103 somerases protect against genome instability by relieving topological stress(6), their activity may a

104 n for transcription restart at least in part by relieving transcription inhibition rather than by dep

105 reased protein production, at least in part, by relieving translational inhibition.

106 , a fall in pH potentiates kainate receptors by relieving zinc inhibition.