ライフサイエンスコーパス: by replacing

1 2)) can be increased from ~1.0 to 1.2-1.3 eV by replacing ~10% of the sulfur atoms with oxygen atoms

2 O1A disrupting the last 2 C-terminal domains by replacing 61 amino acids with a novel 91-amino-acid s

3 The mu2 binding geometry is achieved by replacing a belt-sulfur atom (S2B) and highlights the

4 These variants were obtained by replacing a charged amino acid residue at different s

5 Hence, by replacing a conventional generic NKA model with our r

6 we demonstrate conductance switching in DNA by replacing a DNA base with a redox group.

7 generated a panel of synthetic AAV2 vectors by replacing a hexapeptide sequence in a previously iden

8 teracts with the ligand-binding domain of AR by replacing a high-affinity labeled ligand (IC(50) 0.4

9 By replacing a hydrophobic leucine in the center of the

10 we report a novel viral glycoprotein created by replacing a natural receptor-binding sequence of the

11 lished concept of oligospiroketal (OSK) rods by replacing a part or all ketal moieties by thioketals

12 By replacing a percentage of the bridging ligand (tereph

13 Solubility of the template was improved by replacing a planar aryl linker with a saturated pyrro

14 vates membrane lipids when phosphate starved by replacing a portion of its phospholipids with monoglu

15 By replacing a pyrrolic unit within the porphyrin framew

16 nana shape of the molecule can be controlled by replacing a Si atom within the dithienosilole fragmen

17 dically improved, without extra expenditure, by replacing a small number of protected areas with new

18 l approach to create new functional proteins by replacing a specific amino acid in a protein with its

19 We created 12 GLIC-5-HT(3A)-ICD chimeras by replacing a variable number of amino acids in the sho

20 llele of ABC-me (ABC-me(+/-)) were generated by replacing ABC-me exons 2 and 3 with a neomycin resist

21 The efficiency of DNA synthesis is increased by replacing adenine with diaminopurine in both the GNA

22 soluble NPC1 lumenal domain 2 was engineered by replacing adjacent transmembrane domains with antipar

23 e intestinal tract maintains proper function by replacing aged cells with freshly produced cells that

24 e-free HIV-1 Nef mutant (Delta10K) generated by replacing all 10 lysines with arginines was not ubiqu

25 -alpha factor were not significantly altered by replacing all lumenal proteins with only protein disu

26 markably, normal KNL1 function is maintained by replacing all modules with a short array of naturally

27 enic CE(NiP) in which the P gene was mutated by replacing all of the start codons (AUG) for tPs with

28 UTR-localized diSSRs of other genes evolved by replacing alternative diSSRs, by replacing mononucleo

29 solubility and stability of these analogues by replacing amino acids further away from the motif.

30 fic cleavage by ERManI and GMIA was explored by replacing an essential enzyme-bound Ca(2+) ion with a

31 caffold was realized in a synthetic sequence by replacing an interhelical ionic bond with a covalent

32 y a preorganized pi-turn, which was obtained by replacing an N-terminal intramolecular main chain i a

33 eriplasmic end of helix VI) were constructed by replacing Asp with Glu, Gln, or Cys and R175 with Gln

34 ycosylation site was eliminated individually by replacing asparagine (N) with glutamine (Q), and a do

35 markedly diminished cAMP generating capacity by replacing aspartic acid with alanine at position 426

36 ion of Serbian margarines should be improved by replacing atherogenic TFA and SFA with beneficial one

37 system, we generated the Necl-1 mutant mice by replacing axons 2-5 with the LacZ reporter gene.

38 Wnt signaling turns ZEB1 into an activator by replacing binding of CtBP/BRG1 in favor of p300.

39 Improvement in maternal care imposed by replacing biological EL dams with foster CD-1 mothers

40 alcium-selective currents, which was reduced by replacing Ca(2+) with Ba(2+) and reversed by SOC inhi

41 sensitivity of cardiac muscle can be reduced by replacing cardiac troponin I with its skeletal or neo

42 Ski negatively regulates TGF-beta signaling by replacing CBP in R-Smad complexes.

43 We also modified the experimental system by replacing CFP with the SgrS small RNA, which regulate

44 stribution, and these variants were obtained by replacing charged and neutral amino acid residues at

45 ines markedly improves the stability of HP35 by replacing charged with nonpolar residues, stabilizing

46 esterol required to promote influenza fusion by replacing cholesterol with other sterols and assaying

47 lity of MDR to detect gene-gene interactions by replacing classification error with a different measu

48 nimals with the receptor antagonist RP67580, by replacing ClO(-) with SP in vivo, and by immunofluore

49 n (CSR) generates different antibody classes by replacing Cmu with a downstream CH.

50 en cocaine-seeking behavior was extinguished by replacing cocaine with saline.

51 nditions promote SGG colonization of the gut by replacing commensal enterococci in their niche.

52 ms, we disrupted the Speg gene locus in mice by replacing common exons 8, 9, and 10 with a lacZ gene.

53 By replacing components of this model, we demonstrate th

54 icient CPPs can be derived from maurocalcine by replacing Cys residues by isosteric 2-aminobutyric ac

55 educed SR K(+) channel conduction 35 and 88% by replacing cytosolic K(+) for Na(+) or Cs(+) (respecti

56 this amino acid to trimerization and fusion by replacing D188 with alanine (D188A) or lysine (D188K)

57 ommend the modification of the AIDA protocol by replacing d3-2,4-dinitrophenylhydrazine with (15)N- o

58 from scratch, bacteria can repair ribosomes by replacing damaged proteins in situ, thereby saving si

59 sity were initiated within 8 wk in the OW/OB by replacing deficiencies in Western diets without requi

60 multiple blood indicators in the sample chip by replacing different types of enzyme in alginate bead

61 cells able to give rise to monoclonal glands by replacing each other following a pattern of neutral d

62 eras, and gL point mutants could be restored by replacing EBV gB with Rh gB.

63 dress the roles of Gli2 ciliary localization by replacing endogenous Gli2 with Gli2(DeltaCLR), a Gli2

64 By replacing endogenous NuMA with membrane-binding-defic

65 These two models were tested by replacing endogenous protein with ZP2 that cannot be

66 behavior of rabbit psoas skeletal myofibrils by replacing endogenous Tm and troponin (Tn) with recomb

67 ted 1 here) that was generated from GCN4-pLI by replacing every third alpha-amino acid residue with t

68 Slurp1-deficient mice (Slurp1(-/-)) created by replacing exon 2 with beta-gal and neo cassettes.

69 his, we targeted the ASPP2 allele in a mouse by replacing exons 10-17 with a neoR gene.

70 s of a global knock-out of Na(V)1.9 produced by replacing exons 4 and 5 in SCN11A with a neomycin res

71 hilicity of the former light chain interface by replacing exposed hydrophobic residues with structura

72 t, and pluripotent stem cells are maintained by replacing FGF2-containing media daily, while tissue-s

73 DAIP variants were prepared by replacing four of five glutamines for asparagines in

74 strength of GAL80-mediated negative feedback by replacing GAL80 promoter is necessary and sufficient

75 GEFs activate Arf by replacing GDP with GTP.

76 saccharomyces pombe cells switch mating type by replacing genetic information at the expressed mat1 l

77 osaccharides (COs) and insoluble chitin, and by replacing GlcNAc with 2-acylamido analogues of GlcNAc

78 chain entropy by introducing cross-links or by replacing glycines.

79 The effects of the latter can be alleviated by replacing guanine with inosine, which removes the N2

80 structural basis for chromosome segregation by replacing H3 at centromeres.

81 ve anthropomorphic impacts on the ecosystem; by replacing impacts with ecosystem services the EBM-DPS

82 ry guidelines to improve dietary fat quality by replacing intake of SFAs with n-6 and n-3 PUFAs.

83 at many of these limitations can be overcome by replacing interferometric optics with a two-dimension

84 to low pH-induced unfolding were constructed by replacing interior histidine residues with phenylalan

85 The effective hole doping is achieved by replacing Ir with Rh atoms, with the chemical potenti

86 juxtamembrane (JM) domain in EGFR signaling by replacing it with a (GGS)(10) unstructured sequence.

87 city of W69 to conformational changes of Env by replacing it with a series of residues with aliphatic

88 ad, when the AWI is removed from the samples by replacing it with a solid-liquid interface, the inter

89 FVIII C domains, we eliminated the C1 domain by replacing it with the homologous C2 domain.

90 d the function of HEV ORF3 can be maintained by replacing it with the well-characterized viroporin in

91 T in which the NTE of mouse cTnT was removed by replacing its 1-73 residues with the corresponding 1-

92 The substrates were pPR itself, inactivated by replacing its catalytic nucleophile (S132A-pPR), and

93 ygen-sensitive, light-inert histidine kinase by replacing its chemosensor domain by a light-oxygen-vo

94 -loop domain from the BCoV 5' UTR was tested by replacing its counterpart in the MHV genome.

95 ma virus (RSV) Env can be made Vpu sensitive by replacing its CTD with the GaLV Env CTD.

96 In the present study, we modified RSV F by replacing its cytoplasmic tail (CT) domain or its CT

97 muscle to be moderately stretch-activatable by replacing its myosin isoform with an embryonic isofor

98 boxyl terminus of Hsc70-interacting protein) by replacing its natural substrate-binding domain with a

99 nces fused to nAuORF2, in a manner abolished by replacing its non-AUG initiation codon (AUA) start co

100 amins, we reengineered the classical dynamin by replacing its PHD with a polyhistidine or polylysine

101 neither by removing the early stop codon nor by replacing its SECIS element.

102 pression was targeted to the yeast cell wall by replacing its signal peptide, serine-threonine-rich r

103 ngineered the human A(2A) adenosine receptor by replacing its third intracellular loop with apocytoch

104 this hypothesis, we targeted ADAM10 to rafts by replacing its transmembrane and cytosolic regions wit

105 Converting dimeric PSGL-1 to a monomer by replacing its transmembrane domain did not alter its

106 A PNP hybrid was produced by replacing K22 and H104 in HsPNP with the correspondin

107 Mimicking acetylation was done by replacing K282, K317, K331, K338, K539, or K542 with

108 By replacing key amino acid residues in AmTrac we constr

109 hannel mutant that remains open up to pH 9.0 by replacing key ionizable residues from the N and C ter

110 s, was engineered into sperm whale myoglobin by replacing Leu29 and Phe43 with Glu and His, respectiv

111 e designed a mutant form of PAR4, "PAR4SFT," by replacing LGL194-196 at the base of transmembrane dom

112 We show improved power conversion efficiency by replacing lithium salts, typical p-dopants for spiro-

113 atterns and to maintain these configurations by replacing lost atoms with surplus atoms from a reserv

114 o determine if IOP control can be maintained by replacing lost TM cells, we transplanted TM-like cell

115 By replacing LptD residues with an unnatural amino acid

116 However, removing the charge by replacing Lys53 with methionine caused more than a mi

117 tylation of lysine 310 by depleting SIRT1 or by replacing lysine 310 with acetyl-mimetic glutamine in

118 By replacing lysine residues at proposed phospholipid-bi

119 articularly in the photomorphogenesis field, by replacing many tedious, error-prone manual measuremen

120 The mat1 switching occurs by replacing mat1 with a copy derived from a silenced "d

121 sustainable restoration of yeast cell growth by replacing missing protein ion transporters with imper

122 Further stabilization is realized by replacing monofunctional ligands with difunctional ve

123 nes evolved by replacing alternative diSSRs, by replacing mononucleotide-rich tracts and, in fewer ca

124 in mTOR-targeting selectivity were achieved by replacing morpholine in pyrazolopyrimidine inhibitors

125 eatment of Duchenne muscular dystrophy (DMD) by replacing mutant dystrophin or restoring dystrophin-a

126 By replacing naphthyl with quinoline moieties, we prepar

127 ity in juvenile rat brain slices were probed by replacing native channels blocked with the dihydropyr

128 can be re-targeted to sequences of interest by replacing native DNA-binding domains (DBDs) with engi

129 inine ratio was lower, but could be improved by replacing non-targeted creatinine measurements with a

130 ol accumulation and damage, which is rescued by replacing Nrf1 exogenously.

131 ble for depositing the histone variant H2A.Z by replacing nucleosomal H2A with H2A.Z.

132 by Ti, Mn, Co, Ni, or Si and F anion doping by replacing O on the fully hydroxylated surface.

133 as pyrrolic/graphitic-nitrogen, were formed by replacing of oxygen-containing functional groups.

134 Contractile function was rescued by replacing oleate with a medium-chain fatty acid or by

135 Additional WNV chimeric viruses made by replacing one or more W956IC genes with the lineage 1

136 ng with a biphenyl lead, bioisosteres formed by replacing one phenyl by pyridine or pyrimidine showed

137 ing structure in the NHR4 domain of AML1-ETO by replacing only one critical amino acid leads to rapid

138 anic colloidal nanocrystals were synthesized by replacing organic capping ligands on chemically synth

139 gy preserves the health of cells and tissues by replacing outdated and damaged cellular components wi

140 Specifically, this can be accomplished by replacing pairs of not necessarily adjacent C atoms w

141 ion in CO2 reduction is further demonstrated by replacing Pd with Rh.

142 ed the hydrophobic moment of the alpha-helix by replacing Phe(604), Ile(608), or Ile(612) by Gln.

143 pi conjugation was systematically extended (by replacing phenyl with naphthyl), fluorescence quantum

144 Addition of pyridine is known to unfold DNA by replacing pi-pi stacking interactions between bases,

145 yres actively reduce their phosphorus demand by replacing polar membrane phospholipids with those lac

146 ab-coated rods on cells was enhanced further by replacing polystyrene particles with pure chemotherap

147 We explored this hypothesis by replacing previously identified domains and critical

148 y profile of proline cis-trans isomerization by replacing Pro32 with a series of 4-fluoroprolines via

149 ol methacrylate) appears to enhance activity by replacing protein-water interactions, thereby preserv

150 This property could be restored in 2009/NS1 by replacing R108, E125, and G189 with residues correspo

151 ncreasing the number of discriminatory sites by replacing R5M with I2 inactivated extrachromosomal or

152 The acceleration is achieved by replacing regular KMC jumps in trapping energy basins

153 tients with severe combined immunodeficiency by replacing resident thymus cells.

154 dence as we perturb the Ru honeycomb lattice by replacing Ru with Li.

155 ng the macronutrient composition of the diet by replacing SFAs with unsaturated fatty acids, as well

156 52 mutants were made by replacing single or clustered charged amino acids wit

157 P2X2, P2X3, and P2X6 subunits were generated by replacing single, homologous amino acids particularly

158 A mutant constructed by replacing SL4 with a shorter sequence-unrelated stem-

159 cacy of the CREKA peptide was then increased by replacing some residues with nonproteinogenic counter

160 ly of sodium-ion battery electrodes obtained by replacing stepwise the oxygen atoms with sulfur atoms

161 They can then be modified by replacing surface-bound proteins with engineered, het

162 in lesion uptake measurements can be reduced by replacing SUV with SUR as the uptake measure.

163 mation in the absence of viral oncoproteins, by replacing SV40 large T and small T antigens with sh-p

164 ctions can be used to develop novel yogurts, by replacing synthetic preservatives and improving the a

165 ss on cell function and/or their restoration by replacing targeted genes one at a time.

166 ooking and discarding the soaking water, and by replacing tea and coffee at meals with vitamin C-rich

167 amination of TBDx scanty smears was explored by replacing the "positive" result of slides with 1-9 AF

168 activity with carbocyclic LNA (cLNA) analogs by replacing the 2'-oxygen atom in LNA with an exocyclic

169 ne-like analogues were systematically varied by replacing the 2,4 substituents on toluene with hydrog

170 zol-4-yl]ethynyl]benzonitrile), was modified by replacing the 2-fluoromethyl substituent with an amin

171 ng and hydroperoxide-decomposing antioxidant by replacing the 2-methyl substituent with an alkyltellu

172 twofold improvement in potency was achieved by replacing the 226-aa N6 spacer with a novel 17-aa pep

173 of the AcMNPV GP64 transmembrane (TM) domain by replacing the 23-amino-acid GP64 TM domain with corre

174 normal steady-state level of PPARgamma mRNA by replacing the 3'-UTR of the natural Pparg gene with t

175 data guided our redesign of AMP, which began by replacing the 5'-phosphate with a phosphonic acid att

176 ional cores of Slo1 channels to be expressed by replacing the 827-amino acid gating ring with short t

177 regenerative process is completely restored by replacing the ablated eCSCs with the progeny of one e

178 AOX2 rescued the im defect by replacing the activity of PTOX in the desaturation st

179 e efficiently copied sequences are generated by replacing the adenine nucleobase with diaminopurine,

180 that modify cytosine exclusively were formed by replacing the adenine target recognition domain (TRD)

181 hile they burn in air, this can be prevented by replacing the air with nitrogen.

182 The clock can be stopped by replacing the alkanes with the superior guest 4,4'-di

183 s [3]rotaxane is obtained in excellent yield by replacing the amine with a diamine, thus showing the

184 tion of the quinoline ring of tipifarnib and by replacing the amino group by OMe.

185 This was demonstrated by replacing the amino group with a more basic guanidine

186 Improved potency was achieved by replacing the androstane nucleus with a pregnane nucl

187 e to the detection of other analytes, merely by replacing the anti-human IgE aptamer/cDNA G1 pair wit

188 array offers an easier manufacturing process by replacing the antibody printing step with DNA printin

189 Further study revealed that by replacing the aryl substitution on the imidazole ring

190 graphic studies of Fe(II)-M121E azurin (Az), by replacing the axial Met121 and Cu(II) in wild-type az

191 hiometries were compared with those obtained by replacing the bacteria by polystyrene microbeads to d

192 Electrochemical studies indicate that by replacing the BIPY(2+) units in homo[2]catenane HC(*7

193 A wing domain chimera was constructed by replacing the BirA wing with the nearly isosteric win

194 By replacing the C-terminal carboxylate of ubiquitin (Ub

195 By replacing the carboxylate group in peramivir with a p

196 ibitors by modifying the structure of NSAIDs by replacing the carboxylic acid functionality by sulfon

197 A resolution structure of an inactive form (by replacing the catalytic nucleophile Ser 221 with alan

198 ping BACs to construct a full-length CCV BAC by replacing the CCV ORF5 with the BAC cassette and cotr

199 Here, we produced variants by replacing the conserved Thr-18 residue in the small s

200 zoline-2-thione rings by oxygen atoms and/or by replacing the coordinating sulfur atoms by selenium a

201 itive detection of AFB1 and other mycotoxins by replacing the core recognition sequence of the aptame

202 to NMDAR-dependent Ca(2+) influx is lowered by replacing the CTD of GluN2B with that of GluN2A by ta

203 e thiophene head was simplified even further by replacing the cyclohexane ring with an isobutyl group

204 Complementation of the deletions by replacing the deleted genes on the chromosome restore

205 Altering the leaving group pK(a), by replacing the departing nucleoside with analogues, ha

206 athway in a computationally efficient manner by replacing the detailed model by a surrogate meta-mode

207 By replacing the DNP station with a butadiyne group, the

208 Using this approach, we demonstrate that by replacing the electrolyte during regeneration for a s

209 scribed with the same mathematical formalism by replacing the electron-phonon coupling parameter in L

210 robed the requirements for particle assembly by replacing the entire first or third TM domain of HBsA

211 which was optimized for metabolic stability by replacing the ester moiety with a methyl oxadiazole b

212 ed in existing photoluminescence instruments by replacing the excitation light source (short duty cyc

213 SV2B alone, expressed in chimeric receptors by replacing the extracellular domain of the low-density

214 We generated a recombinant F-chimeric RSV by replacing the F gene of A2 with the F gene of 2-20, g

215 We generated recombinant, F-chimeric RSVs by replacing the F gene of A2 with the F gene of either

216 color-pure electroluminescence are obtained by replacing the F8 electron injector with ZnO, which is

217 eveloped an A-419259-resistant mutant of Hck by replacing the gatekeeper residue (Thr-338; c-Src numb

218 04 RPS was converted to that of strain SK144 by replacing the gene (wefM) for the fourth transferase

219 ormance of the MTBDRsl LPA might be improved by replacing the gyrA wild-type probes by additional pro

220 By replacing the heme in a biosynthetic model of NORs, w

221 onstructed additional chimeric HSV-2 viruses by replacing the HSV-2 LAT promoter (HSV2-LAT-P1) or 2.5

222 aired Siglec receptors, we generated a model by replacing the inhibitory domain of mouse Siglec-E wit

223 driven GFP in this strain could be abolished by replacing the intact ohrR gene with a mutant ohrR gen

224 1A, suggesting that nickel causes inhibition by replacing the iron.

225 elop along the lines of physics or economics by replacing the latter with the former.

226 c (HMMM) model with accelerated lipid motion by replacing the lipid tails with small organic molecule

227 Here, we tested this model by replacing the loop from Escherichia coli EnvZ, which

228 ays, but also was inexpensive and convenient by replacing the magnetic separation with filtration pla

229 nded, approximately 21 nt long, and designed by replacing the mature miRNA sequences of duplex within

230 nist to antagonist was successfully obtained by replacing the methyl group in position 6 of the 1,4-d

231 By replacing the mouse alpha-globin gene cluster in situ

232 Ion Mobility Spectrometry (IMS) was improved by replacing the multicapillary column (MCC) with a capi

233 y transformed into their activated analogues by replacing the N-benzyl protecting group with a N-tosy

234 sed to produce a functional Sgs1-BLM chimera by replacing the N-terminus of BLM with the disordered N

235 le or multiple Gly --> Leu substitutions) or by replacing the N-TM domain with those from other CD36

236 emarkably, nucleosome centering was achieved by replacing the native DNA-binding domain of Chd1 with

237 A conditional mutant, constructed by replacing the native promoter of the A. fumigatus uap

238 locking its oncolytic potential in the brain by replacing the neurotropic VSV glycoprotein with the g

239 cell permeable Pin1 inhibitors was designed by replacing the noncritical residues within the cyclic

240 l LGE MR imaging pulse sequence was modified by replacing the nonselective inversion pulse with a wid

241 of the natural product psammaplin A obtained by replacing the o-bromophenol unit by an indole ring.

242 By replacing the outer layer with fluorescently tagged,

243 cation of biotinylated nuclei was redesigned by replacing the outer nuclear-envelope-targeting domain

244 ( horizontal lineS)(2)], has been developed, by replacing the outer sulfur atoms of the thiazoline-2-

245 ce-immobilized Ag nanoparticles is inhibited by replacing the oxygen dissolved in water with argon ga

246 R observed with its removal can be increased by replacing the phenol OH with a chlorine substituent,

247 Potency was enhanced by replacing the piperidine moiety by N,N-dibutyl, N,N-d

248 By replacing the polymeric donor PBDTBDD with its 2D-con

249 By replacing the PPII helix of a miniature protein, the

250 liVAX technology to produce a dengue vaccine by replacing the prM/E genes of RepliVAX WN (a West Nile

251 converts glycerol to clean hydrogen fuel and by replacing the problematical coke formed on the cataly

252 -equivalence of tropomyosin's periodic sites by replacing the proposed binding sites by substituting

253 ed, single-component Cas9 variant engineered by replacing the protein's REC2 domain with the BCL-xL p

254 These phenotypes could be bypassed by replacing the PrP(C) signal sequence with that of pro

255 expression in Escherichia coli was obtained by replacing the pulE-K putative pilin genes of the Kleb

256 hobic region within the AMP binding site and by replacing the purine nitrogens N1 and N3 with carbons

257 This main aim has been accomplished by replacing the rapidly hydrolyzable Schiff-base moiety

258 A conditional double mutant was created by replacing the remaining wild-type allele of ITR1 in a

259 Additional binding affinity was gained by replacing the ribose with an alkyl group that formed

260 eliminated without compromising infectivity by replacing the RSV Gag N-terminal matrix (MA) domain w

261 By replacing the SBH loop with ligand-controlled RNA-cle

262 e photovoltage barrier can be readily broken by replacing the semiconductor/water interface with a se

263 We generated a series of novel SFKs by replacing the SH2 and SH3 domains of Hck with the syn

264 This was achieved by replacing the single VSV glycoprotein (G) with human

265 er by providing electron shuttles (confirmed by replacing the sludge with humic acids), and (iii) Geo

266 SV-01, a chimeric virus (FL01) was generated by replacing the structural genes of type II PRRSV strai

267 in vitro potency of triclosan significantly by replacing the suboptimal 5-chloro group with larger h

268 prove the oxidative stability of the peptide by replacing the sulfur in lanthionine with a methylene

269 between the classes is artificially degraded by replacing the SVM model with an ad hoc k-means classi

270 spherical supramolecular dendrimer was made by replacing the tapered dendron, from the previously re

271 rambled form of P947 (P1135) was synthesized by replacing the targeting moiety of P947 with a scrambl

272 silon = -RTln(C(w)/C(w) (sat)) was redefined by replacing the term (C(w)/C(w) (sat)) with the normali

273 an PNP (Leuko-PNP) was previously engineered by replacing the three Trp residues of native PNP with T

274 xisting pairwise sequence alignment packages by replacing the time-consuming seed extension phase wit

275 , we have generated a soluble F (sF) protein by replacing the transmembrane and cytoplasmic tail doma

276 Here, we overcome this limitation by replacing the transmembrane domain with a soluble hex

277 We tested the effects of TREX1 D18N in vivo by replacing the TREX1 WT gene in mice with the TREX1 D1

278 r, GPHPVIVITGPHEE (KD approximately 500 nM), by replacing the two valine residues with tert-leucine a

279 iciency and simplify morphology measurements by replacing the typical fullerene acceptor with endohed

280 By replacing the usual sodium hydroxide lysis solution w

281 ribe the trapping of the captodative radical by replacing the vinylic carboxylic acid with an amide.

282 n vivo, we have generated a "knock-in" mouse by replacing the wild-type cyclin D1 gene with a mutant

283 ncreases the sophistication of IBW equations by replacing them with a single universal equation that

284 channel gating and ion permeation was probed by replacing them with amino acid residues of increasing

285 By replacing these residues through site-directed mutage

286 ated product, plasmin (hPm), are compromised by replacing these two amino acids by their murine count

287 re and function of this protein was assessed by replacing this domain with the F protein TM domains f

288 By replacing this N-terminal motif with well-characteriz

289 oride treatment or mimicking phosphorylation by replacing Thr-53, Thr-58, and Ser-71 residues with As

290 ession in Escherichia coli has been achieved by replacing three fourths of the transmembrane pore wit

291 shapes is manipulated by removing a shape or by replacing training shapes with unfamiliar ones.

292 se telomeres either through gene deletion or by replacing TRF2 with a mutant that does not bind Rap1.

293 This was possible by replacing two residues, Arg-67 and Ile-82, in the fir

294 ere we mimic phosphorylation of cytochrome c by replacing tyrosine 48 with p-carboxy-methyl-l-phenyla

295 A set of additional chimeras was made by replacing various W956IC gene regions with the Eg101

296 ost by W26A-HNP1 were restored progressively by replacing W26 with non-coded, straight-chain aliphati

297 le of this phenomenon can only be elucidated by replacing wild type arrestin-1 in living animals with

298 50 degrees C to remove the Si-Cl termination by replacing with Si-H termination as confirmed by XPS,

299 effect of the Y21 pKa on dark state recovery by replacing Y21 with fluorotyrosine analogues that incr

300 [Re]-beta2 was further modified by replacing Y356 with 2,3,5-trifluorotyrosine to enable