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1 ed aminoborane anions with AB, are supported by the fact that 1 was observed to react with an additio

2 This was supported by the facts that 1) liposome-delivered blocking Ab agai

3 y afflicting geriatric patients as evidenced by the fact that 80% of all non-melanoma skin cancers ar

4 o provide a complete picture as demonstrated by the fact that 8000-10 000 papers are curated in UniPr

5 are contingent on RORgammat, as highlighted by the fact that a genetic deficiency for RORgammat, or

6 derstanding of parasite evolution is impeded by the fact that a large fraction of the genome is eithe

7 These findings are supported by the fact that a selective BF-3 inhibitor or mutations

8 This interaction was confirmed by the fact that a subcomplex of PhK missing the beta su

9 he heterogeneous nature of the substrate and by the fact that a true steady state cannot be attained.

10 t cause of cognitive impairment as evidenced by the fact that Abeta load severity is decoupled from r

11 ry of novel, effective therapies is hampered by the fact that advanced age, primary age-related tauop

12 f our data to human conditions was reflected by the fact that all human basal cell carcinomas examine

13 most likely parent radioligand, as supported by the fact that all plasma radiometabolites of (11)C-NO

14 inst G8 strains might be partially explained by the fact that all these strains contain a complete or

15 This may in part be explained by the fact that almost 40% of the isolates were genetic

16 ever, clinical decision-making is confounded by the fact that although LAAC attenuates the anticoagul

17 CTNNBL1 was also implicated in mammalian CSR by the fact that an AID mutant that fails to interact wi

18 This was confirmed by the fact that an immobile condensed organic phase suc

19 This problem is further complicated by the fact that an intrinsic characteristic of regulato

20 are lacking, because they have been hindered by the fact that ANT1 expression leads to apoptotic cell

21 This role for ROS was further supported by the fact that antioxidants blocked GTPP-induced preco

22 ion; however, these findings are complicated by the fact that ApoE knock-out mice have highly elevate

23 This mechanism is further supported by the fact that Au NPs embedded in a matrix of butyl-3-

24 This is supported by the fact that axotomy results in increased CGRP produ

25 accuracy in the very recent past is hampered by the fact that, because of the small sample size, only

26 This response can be explained by the fact that bortezomib induced a dramatic decrease

27 e importance of this finding was highlighted by the fact that both Il21r-/- mice and WT mice treated

28 This latter function is confirmed by the fact that Brg1 mutant mouse embryos and RNAi knoc

29 importance of this finding was demonstrated by the fact that cathelicidin knockout mice (Camp(-/-))

30 ia-mediated apoptosis as evidenced, in part, by the fact that cell death was inhibited to a similar e

31 Its biological importance is demonstrated by the fact that cells lacking Ssq1 grow poorly when Isu

32 driven adaptive motor learning, as evidenced by the fact that cerebellar patients do not adapt well t

33 This is supported by the fact that CERK1 is a target of the bacterial type

34 This challenge is made more difficult by the fact that changes in the climatic and environment

35 tion of this potential hazard is complicated by the fact that chemical composition, which affects the

36 quantity of implanted cells and is hindered by the fact that chondrocytes cultured for long periods

37 was of physiological significance was shown by the fact that chronotropic responsiveness to the A1-A

38 otropic effect of JH in queens was suggested by the fact that circulating levels of JH were ca. 2 ord

39 ificial versus physiological conditions, and by the fact that ClC-2 rectification is neither complete

40 This can be explained by the fact that coarse and PE bran hold more weakly bou

41 gree of column shrinkage, a result explained by the fact that column shrinkage causes disproportionat

42 al concept quinone/cannabinoid was supported by the fact that compound 10 exerts antitumor effect by

43 biquitination and degradation is underscored by the fact that constitutively active Cdc42(F28L) incre

44 This possibility is made salient by the fact that contempt can be defined by contrast wit

45 try beyond molecules is further strengthened by the fact that covalent reactions can be carried out o

46 This is easily explained by the fact that Cu(I) is preferably 4-coordinate and Cu

47 health threats whose threats are compounded by the fact that current techniques for testing the susc

48 acute rejection have been reported, favored by the fact that cytotoxic T lymphocyte-associated prote

49 This is further complicated by the fact that datasets obtained will exhibit incident

50 ructural variance in the deaf is complicated by the fact that deaf individuals also differ in their l

51 teins in cellular homeostasis is underscored by the fact that defects in BLM, WRN, and RECQL4 are lin

52 nsible for the inflammatory colitis as shown by the fact that deletion of Tcrd abolished spontaneous

53 ClipR-59 palmitoyltransferase, as evidenced by the fact that DHHC17 interacted with ClipR-59 and pal

54 tudying single trial responses is reinforced by the fact that different brain processes are correlate

55 This idea is supported by the fact that disruption of IL-17 signaling (IL-17 re

56 oaches the maximum theoretical limit imposed by the fact that distant relatives frequently share no D

57 -order molecular architectures made possible by the fact that DNA is a programmable information-codin

58 hibition of HCC growth was further supported by the fact that DNMT1 overexpression prevented miR-185-

59 portance of TDP-43 in disease is underscored by the fact that dominant missense mutations are suffici

60 This is largely caused by the fact that during viral persistence CD4 T cells do

61 Their importance is further indicated by the fact that dysregulation or mutation of a macrodom

62 of these factors in epidermis is complicated by the fact that each member is expressed in defined cel

63 EGCG-induced LC3-II formation, as evidenced by the fact that EGCG-induced LC3-II formation was signi

64 ic reaction of nitrogenase has been hampered by the fact that electron and proton flow in this system

65 In part, this may be caused by the fact that endophytic fungi form a rather heteroge

66 he enzyme, this reduction is almost balanced by the fact that enzyme and substrate are concentrated a

67 ccine approaches, however, has been hampered by the fact that every patient's tumour possesses a uniq

68 relevance of these findings was demonstrated by the fact that ex vivo up-regulation of CR1 on leukocy

69 of this counteraction mechanism is hampered by the fact that existing force fields fail to capture t

70 ding the cyclin B1 promoter was demonstrated by the fact that expression of inducible dominant negati

71 distinct feedback mechanisms is illustrated by the fact that expression of oncogenic BRAF(V600E), a

72 ating states of consciousness is highlighted by the fact that extrasynaptic GABA(A) receptors (GABA(A

73 Supported by the fact that FF3 twins remain accessible within the

74 ation and dissociation reactions is hampered by the fact that forward and reverse reactions to/from d

75 e-scale dendritic organization was supported by the fact that functional groups of spines defined by

76 ell development and maintenance, highlighted by the fact that Gata2 haploinsufficiency has been ident

77 of the BAP1-HCF-1 interaction is underscored by the fact that growth suppression by the dominant nega

78 ar sensory hair cells, and we were intrigued by the fact that hair cells are able to cope with expres

79 Its importance for catalysis is underscored by the fact that histidines are localized to active site

80 assess a role in pathogenesis is complicated by the fact that HIV-1 isolates vary continuously in the

81 Our mouse data are supported by the fact that human astrocytoma and oligodendroglioma

82 liam Curtis' Flora Londinensis, I was struck by the fact that I was looking at images of dimorphic Pr

83 of Parkinson's disease is strongly supported by the facts that (i) missense and copy number mutations

84 This could be accounted for by the fact that in FSHD myoblasts, functionally importa

85 s function in this tissue has been precluded by the fact that in the Six3-deficient embryos the pitui

86 terpretation of these studies is complicated by the fact that, in a majority of studies, the CNV sign

87 The spectroscopic similarities are explained by the fact that, in both materials, photogenerated hole

88 This was further supported by the fact that inhibiting the co-translational interac

89 ese proteins in cell activation is suggested by the fact that inhibiting the expression of each using

90 during systemic in vivo infection, as shown by the fact that inhibition of NOS2 with 1400W reduced s

91 Psychiatric genetics has been hampered by the fact that initially exciting findings from underp

92 concentrations by this assay is complicated by the fact that it also acts as a substrate for the L-g

93 YAQ(12)A but also fibril extension, as shown by the fact that it also inhibits seeded fibril growth w

94 ion as respiratory allergen may be explained by the fact that it becomes airborne and respirable thro

95 cell cycle at G2/M phase, which is explained by the fact that it inhibits tubulin polymerization.

96 as nanotechnology and health is underscored by the fact that it is currently the ninth-most mined me

97 approaches to clinical contexts are hampered by the fact that it is not known whether humans manifest

98 ) in human inflammatory diseases is hampered by the fact that it is virtually undetectable in human p

99 of this diet-induced growth was highlighted by the fact that it occurred both in male mice and with

100 our cellular understanding has been limited by the fact that it occurs very rapidly: invasion is gen

101 However, PSI-BLAST's performance is limited by the fact that it relies on deterministic alignments.

102 l10 autophagy was highly selective, as shown by the fact that it spared Malt1, a direct Bcl10 binding

103 ibutes to melanoma metastasis is underscored by the fact that its therapeutic inhibition by the EDNRB

104 s subsequent clinical course was complicated by the fact that IV calcium was not a viable option for

105 Kaiso to epigenetic silencing was underlined by the fact that Kaiso depletion induced tumor suppresso

106 se input-output relationships is complicated by the fact that layer 4B, which provides outputs to dor

107 (PAG) plays a central role, as demonstrated by the fact that lesions in the PAG lead to complete mut

108 activity to Atm1p depletion were confounded by the fact that LEU2 was used as a selectable marker to

109 of the research randomization sequence, and by the fact that LHJs did not constitute truly isolated

110 t for developmental events, we are intrigued by the fact that Lis1 and Ndel1 expression remain high i

111 derstanding the role it plays is complicated by the fact that little is known about the corresponding

112 of X-chromosomal information is complicated by the fact that males only have one copy.

113 on and data for a specific model is hampered by the fact that many authors do not adhere to existing

114 valence throughout the bacterial kingdom and by the fact that many bacteria contain dozens, or someti

115 appear to be of ancient origin, as indicated by the fact that many features of cell death strategy ar

116 and lost productivity worldwide, compounded by the fact that many patients are not effectively treat

117 e to healthy or to host cells is complicated by the fact that many proteins are very similar between

118 full extent of such heterogeneity is limited by the fact that MCs containing either tryptase only or

119 e MEP pathway to Francisella is demonstrated by the fact that MEP pathway mutations are lethal.

120 f mouse models of MERS-CoV has been hampered by the fact that MERS-CoV does not replicate in commonly

121 e but with multiple metabolites, facilitated by the fact that metabolite panels often include metabol

122 -2 mediated joint inflammation, as evidenced by the fact that mice deficient in NOD-2 showed signific

123 ting these findings to humans is complicated by the fact that mice lack miR-33b, which is present onl

124 ficient mice, but this finding was explained by the fact that Mo-MLV infection did not induce detecta

125 lusive goal of genome projects, as witnessed by the fact that (model) genomes typically undergo sever

126 This paradox is explicable by the fact that modification by isoLGs renders calpain-

127 However, biofilm studies have been hampered by the fact that most assays utilize nonliving surfaces

128 Inspired by the fact that most natural images are sparse in some

129 evance of this model is further demonstrated by the fact that most of the epitopes identified in our

130 This interpretation is complicated by the fact that most of the methods intended to demonst

131 This strategy was supported by the fact that most patients with diabetes have a hist

132 ips among the World's languages is bedeviled by the fact that most words evolve too rapidly to preser

133 our are of great importance, but complicated by the fact that movement data are complex, multivariate

134 ed histone H2B ubiquitylation is underscored by the facts that MSL1/2 activity is important for trans

135 this visual (retinoid) cycle is underscored by the fact that mutations in genes encoding visual cycl

136 ignificance of this structure is underscored by the fact that mutations within this domain are associ

137 ses sensory information is often complicated by the fact that neurons exhibit trial-to-trial variabil

138 55 and inflammasome activation was supported by the fact that Nlrp3/miR-155 double-knockout allo-HCT

139 This is further supported by the fact that NMDA currents recorded from small neuro

140 ergy loss spectroscopy measurements and also by the fact that no anelastic behaviour could be observe

141 Research training is complicated by the fact that no formal curriculum exists for trainin

142 Studies have been hampered by the fact that no ridgeless mutants have been identifi

143 n the presence of functional p53 as revealed by the fact that normal cells with p53 knockdown by spec

144 er, this useful imaging technique is limited by the fact that not all cancers avidly take up FDG.

145 alysis of RNA tertiary structure is hindered by the fact that not too many structural data are availa

146 y their presence in HD postmortem brains and by the fact that nuclear inclusions are only detected by

147 these strategies will be greatly facilitated by the fact that one operates in water.

148 cell; however, current vaccines are limited by the fact that only a few of the nearly 100 antigenica

149 es (ZFNs) for genome engineering is hampered by the fact that only a subset of sequences can be effic

150 This is exemplified by the fact that only histone H3 and the plant homolog o

151 replicated in larger samples and are limited by the fact that only peripheral methylation could be co

152 ic variation through resequencing is limited by the fact that only sequences with similarity to the r

153 oured by concentration jump experiments, and by the fact that only this mechanism fits the TMA data.

154 , most of these approaches are still limited by the fact that organs and tissues are composed of mult

155 nduced VPAC2 shedding is selective, as shown by the fact that other ciliary membrane proteins includi

156 al force of social mobilization is amplified by the fact that others benefit from the encouraged beha

157 This issue is complicated by the fact that OTRs in finches and voles bind not only

158 an event from the past is often complicated by the fact that our memories are cluttered with similar

159 The usage of RSA was motivated by the fact that our previous work using RSA based linea

160 This observation was supported by the fact that overexpression of p53 in SK-N-SH cell l

161 These results were further supported by the fact that p53 hyperacetylation and increased radi

162 a range of cellular activities, as evidenced by the fact that p63 proteins have been shown to potenti

163 However, its inhibition is complicated by the fact that PAK4 has both kinase-dependent and -ind

164 the diagnosis of human pathogens is hindered by the fact that pathogenic sequences, especially viral,

165 The importance of Aire is highlighted by the fact that patients and mice defective in Aire exp

166 This is highlighted by the fact that patients with perturbed linear ubiquiti

167 ehaviors, and its overall impact is enhanced by the fact that people are embedded within social netwo

168 However, spectral counting is confounded by the fact that peptide physicochemical properties seve

169 lly stochastic version of the model, enabled by the fact that population sizes at the time of measure

170 tation of such data is, however, complicated by the fact that post-lesion behavioral abnormalities co

171 nding of the bile acid metabolism is limited by the fact that previous analyses have primarily focuse

172 mportance of these organelles is highlighted by the fact that primary cilia dysfunction is associated

173 The prion hypothesis is strongly supported by the fact that prion infectivity and the pathogenic co

174 The issue is complicated by the fact that prokaryotes may develop strains differi

175 This conclusion was confirmed by the facts that purified recombinant RFX stimulates mi

176 The problem is complicated by the facts that QTL data usually contain a large numbe

177 This interpretation is complicated by the fact that recollection-based decisions are typica

178 ements and their target genes is complicated by the fact that regulatory elements can act over large

179 ces; however, such conclusions are mitigated by the fact that replaced consonant segments were roughl

180 n the non-HIV population, but is complicated by the fact that response may be worse and there is a ne

181 the role of these neurons have been limited by the fact that RIP expression is predominantly found i

182 rBP-mediated H2AT120p is further underscored by the fact that RNAi knockdown and small-molecule inhib

183 ognitive functioning levels may be explained by the fact that seniors in some regions of the world ex

184 reads to protein families, which is hindered by the fact that short reads contain only a fragment, us

185 Data interpretation is complicated by the fact that short sequencing reads can match multip

186 important for this transition was suggested by the fact that silencing c-Myb significantly decreased

187 tional relevance of these findings was given by the fact that silencing of kappaOR in the LHA attenua

188 d, a characteristic that is well illustrated by the fact that some bacterial tRNAs are efficient and

189 ell axis to immune homeostasis is emphasized by the fact that some of the most effective current trea

190 rmination and proteomic analysis is hampered by the fact that some proteases exhibit slower migration

191 nsional or runaway domain swapping, inspired by the fact that some proteins show an apparent correlat

192 to establish such relationships is hindered by the fact that SSA measurements are typically dominate

193 light cues and of circadian rhythms as shown by the fact that starved period mutants sleep like wild-

194 f subduction and plate tectonics is hampered by the fact that subduction initiation processes must ha

195 be compromised in eyes with multifocal IOLs by the fact that such lenses provide simultaneous vision

196 nd genetic studies of Syk have been hampered by the fact that syk-/- mice die in utero, we have taken

197 pensity-matched registries, can be explained by the fact that SYNTAX enrolled 'real life' patients ra

198 s the significant challenge that is embodied by the fact that targeted pathway modulators may have op

199 ce in these modified cytosines is emphasized by the fact that TET2 is mutated in several human cancer

200 e ligand-mimicking process is also supported by the fact that the ability of GrCLE1 peptides to alter

201 This is further supported by the fact that the addition of a presequence peptide i

202 tors in cells used in fusion experiments and by the fact that the addition of ATP or the enzymatic de

203 This conclusion was supported by the fact that the APC-specific activity in the medium

204 Site selectivity is enabled by the fact that the bacterial synthetase aminoacylates

205 netic analysis of ICP22 has been complicated by the fact that the C terminus of ICP22 is expressed as

206 nergy barriers, and that this is facilitated by the fact that the chromatin fiber within TADs is clos

207 Here, it is shown that the issue is confused by the fact that the clones are heterogeneous.

208 protein cold denaturation have been hindered by the fact that the cold denatured state is normally di

209 closely modulated by DXS activity, as shown by the fact that the concentration control coefficient o

210 o bistability, but its robustness is limited by the fact that the conductance ratio must be within a

211 This hypothesis was validated by the fact that the Cu sorption constants on xanthan we

212 These data were substantiated by the fact that the Deltalpp DeltamsbB double mutant ma

213 ive aggregation of ions on heating is driven by the fact that the dielectric constant of all polar li

214 cAMP and intracellular Ca(2+), as evidenced by the fact that the effect of CRH is mimicked by forsko

215 This result can be explained by the fact that the effects of most mutations are small

216 easurement of product ion m/z is facilitated by the fact that the ELIT is isochronous over the energy

217 he vectorial capacity approach is challenged by the fact that the empirical data violate several of t

218 This conclusion is confirmed by the fact that the estimated number of K(+) ions relea

219 strongly supported by the data as evidenced by the fact that the estimates of the relative risk of i

220 stasis remains incomplete and is complicated by the fact that the four RSK isoforms perform nonredund

221 he state initiating activation, as evidenced by the fact that the fraction of the protein in this sta

222 significance of RhoA flux has been hampered by the fact that the GAP targeting RhoA is not known.

223 postinduction repression is explained partly by the fact that the gene for IkappaBalpha is strongly i

224 The work is motivated by the fact that the genomes of many viruses are large s

225 This is supported by the fact that the H(BB) values extracted from the exp

226 n of label-free biosensors is still hampered by the fact that the immobilization of the bait molecule

227 functioning, but the process is complicated by the fact that the incoming signal is often degraded.

228 This can be explained by the fact that the large cages in SSZ-87 are connected

229 rther advances in this direction are limited by the fact that the lowest flow velocities accessible b

230 This situation is complicated by the fact that the lung has two separate circulations,

231 Researchers have long been perplexed by the fact that the major prostaglandin produced by the

232 This finding was driven by the fact that the majority of UK heathlands receive l

233 e potential of the modular approach revealed by the fact that the microtubes retain the properties of

234 n is shown to be absent in HDC, as evidenced by the fact that the molar mass and radius of gyration o

235 in this active single ring can be explained by the fact that the mutation effectively blocks progres

236 a MO compared to the a(2u) pi MO is balanced by the fact that the non-nearest-neighbor, C-C interacti

237 lts between primates and rodents is hindered by the fact that the organization of descending WM in ro

238 velopment of effective treatments is limited by the fact that the pathology of lymphedema remains unk

239 rmination of the cause of PML was confounded by the fact that the patient had developed oropharyngeal

240 is simple physical description is challenged by the fact that the pattern differs quantitatively betw

241 of oncolytic virus therapy is often limited by the fact that the predicted dynamics depend strongly

242 This enthusiasm should be tempered by the fact that the probability for life to originate i

243 The selectivity is also promoted by the fact that the reaction intermediates produced fro

244 tempted to solve the apparent quandary posed by the fact that the same mutation in two different G pr

245 This was supported by the fact that the same treatment with okadaic acid bl

246 heart, this approach has been disadvantaged by the fact that the signals are derived from tissue hom

247 switching between these states is explained by the fact that the spin texture corresponding to each

248 ediate use of this information is prohibited by the fact that the subnuclear organization of the habe

249 The reaction was complicated by the fact that the substrates contained a racemic prop

250 of an orbital-related state, also supported by the fact that the superconducting energy gap decrease

251 nd immunopathology of IRIS has been hampered by the fact that the symptoms and associated opportunist

252 singly common, their analysis is complicated by the fact that the various biological elements could b

253 to explore the low infectivity are hampered by the fact that the VZV particle-to-PFU ratio has never

254 A proteins into ER membranes as demonstrated by the fact that the YFP-tagged SYP72 localized to the E

255 ormational stability of KAI1/CD82, evidenced by the facts that the mutant is more sensitive to denatu

256 05 cells rolling on E-selectin, as evidenced by the fact that their velocities exhibited a triphasic

257 Not only is issue compounded by the fact that there are fewer pharmaceutical companie

258 Early diagnosis is further complicated by the fact that there are likely many different entitie

259 accine for the common cold has been thwarted by the fact that there are more than 100 serotypes of hu

260 bute to synaptic organization is complicated by the fact that there are significant numbers of separa

261 Northern blot and genetic analyses, but also by the fact that there is an overall sixfold enrichment

262 feeding from obligate nonbiting is hampered by the fact that these different lifestyles occur in sep

263 This can be explained by the fact that these groups make strong favorable inte

264 ts to target endogenous MAPKs are challenged by the fact that these kinases are required for viabilit

265 Their use, however, has been challenged by the fact that these particles are inherently unstable

266 climate on migratory species is complicated by the fact that these species travel through several cl

267 This sensory integration is complicated by the fact that these two modalities encode motion in d

268 ty of these compounds for c-Src is suggested by the fact that they also inhibit clinically relevant A

269 This is compounded by the fact that they are extremely resilient, having ev

270 escribed by their morphological features and by the fact that they are the only proliferative cell ty

271 ot a lipopolysaccharide O antigen, supported by the fact that they contain genes such as wza, wzb, an

272 A limitation of these methods is represented by the fact that they rely on very simple single-layer s

273 This difference can be explained by the fact that thick filaments are more compliant at l

274 targeting fermenting bacteria is exemplified by the fact that this compound prevents the emergence of

275 tanding of Earth's core formation is limited by the fact that this profound event is far removed from

276 rominent basal ganglia iron accumulation and by the fact that this term encompasses a genetically het

277 c understanding of RP105 has been confounded by the fact that this TLR homolog has appeared to have o

278 In fMRI, this is necessitated by the fact that time resolution of a BOLD signal much l

279 The reaction is complicated by the fact that trace amounts of water lead to the form

280 ranscription factors in general, is hindered by the fact that transcription factors are neither secre

281 the structure of the nucleoid is complicated by the fact that transcription is implicated in both com

282 hi proinflammatory activity was demonstrated by the fact that transfer of MyD88-deficient MPhis had m

283 The importance of ROS is evidenced by the fact that treatment of PRCP(gt/gt) mice with anti

284 This notion was supported by the fact that truncated peptides with sequences deriv

285 al role in recruiting Mediator, as indicated by the fact that truncation of either its N- or C-termin

286 nce of tumor evolution is in principle aided by the fact that tumors are heterogeneous, retaining rem

287 of the podocyte structure have been hampered by the fact that ultrastructural analyses require electr

288 This situation is complicated by the fact that, unlike in adults, the trends occurring

289 ar inflammation induced by MDP, as indicated by the fact that uveitis did not develop in Nod2 knockou

290 the perivascular niche was further suggested by the fact that vascular annuli formed around the upper

291 e necessary for accelerated rejection, shown by the fact that vimentin-immunized B-cell-deficient IgH

292 Its importance is highlighted by the fact that viruses such as HIV-2 encode an accesso

293 ism as opposed to other effects is supported by the fact that we obtain different results for the res

294 vivo (genetics), unfortunately, is shadowed by the fact that we scientists have failed to live to th

295 in prokaryotic genomes are further hampered by the fact that well studied data analysis methods for

296 The task is complicated by the fact that while sequence-based features can be re

297 he first step in CMA synthesis, as evidenced by the fact that wild-type levels of coronatine producti

298 This unicity of the gait is also proved by the fact that wild-type worms immediately adapted the

299 They also may be swayed by the fact that workers with the requisite clinical mic

300 The rational use of this system is hampered by the fact that WsaF and other enzymes in the pathway s

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