ライフサイエンスコーパス: by which

1 However, the mechanism by which 53BP1 facilitates deletional CSR and inhibits i

2 Central to this problem is the mechanism by which a brain region adjusts its activity according t

3 Altogether, our results reveal a pathway by which a C-type lectin modulates the equilibrium betwe

4 ering array of potential signalling pathways by which a fall in oxygen levels might initiate Type I c

5 We describe a molecular mechanism by which a microbial community affects animal behavior.

6 These data reveal the molecular mechanism by which a missense variant in APOC3 causes reduced circ

7 is framework describes a suite of algorithms by which a model of the environment, in the form of a st

8 More generally, we demonstrate a mechanism by which a single lesion can cause a complex neuropsychi

9 Determining the mechanisms by which a species adapts to its environment is a key en

10 lts demonstrate an lncRNA-mediated mechanism by which a transcriptional factor conveys a general chro

11 infection in a cell.IMPORTANCE The pathways by which a virus enters a cell transform its packaged ge

12 ung injury model, we explored the mechanisms by which acid exposure initiates macrophage recruitment

13 ine a new component of the signaling network by which activating mutations in the FGF receptor inhibi

14 f tfpi expression is one potential mechanism by which adtrp1 regulates primitive myelopoiesis and def

15 y in delay time to the probabilistic process by which Ag particles detach from a Ag reservoir.

16 Our goal was to delineate a mechanism(s) by which allergic asthma may alleviate influenza disease

17 These findings identify a mechanism by which alterations in cellular glucose metabolism can

18 ur data also reveal the potential mechanisms by which alveolar macrophages mediate protection in vivo

19 These findings uncover new mechanisms by which AMPK could potentially maintain cellular energy

20 Here, we show a mechanism by which an IDP can allosterically control function by s

21 We describe a mechanism by which Ang II stimulates protein kinase C-dependent KV

22 e studies reveal a crucial circuit mechanism by which animals adjust their dietary strategy to mainta

23 Perceptual decision making is the process by which animals detect, discriminate, and categorize in

24 To identify strategies by which animals execute precise actions using sparse mo

25 , and therefore, our data reveal a mechanism by which antigen presentation controls the innate effect

26 tochondria, we demonstrate a novel mechanism by which antimycin-inhibited complex III generates signi

27 er, these results provide a unique mechanism by which AR can either increase or decrease ccRCC metast

28 ng critical insight into the molecular basis by which AR promotes development of lethal PCa and nomin

29 The process by which art paintings are produced typically involves t

30 ) and asbestos exposure, the exact mechanism by which asbestos induces this neoplasm and other asbest

31 The mechanisms by which Atgl is induced during adipogenesis are not ful

32 To explore additional mechanisms by which ATP6V1A overexpressed in GCs, we investigated t

33 Our study proposes a mechanism by which autophagic degradation of Id proteins can regul

34 llicular helper T (TfH) cells, the mechanism by which B cells initially seed germinal center reaction

35 The mechanism by which bacteria divide is not well understood.

36 ndent growth inhibition (CDI) is a mechanism by which bacteria exchange toxins via direct cell-to-cel

37 beta-DG, the intracellular trafficking route by which beta-DG reaches the nucleus is unknown.

38 y, these results shed light on the mechanism by which beta-III-spectrin, and likely similar actin-bin

39 gene expression may be a possible mechanism by which BSJYD provides myocardial protection from hyper

40 interferon pathway as a molecular mechanism by which c-MPL mediates immune stimulation in T cells.

41 ether, our findings reveal a novel mechanism by which Ca(2+) overload disrupts myofibril integrity by

42 Our findings support a model by which CaM binds to Akt to facilitate its translocatio

43 gether, our results reveal a novel mechanism by which CAMK2gamma antagonizes mTORC1 activation during

44 ng with pluripotency, suggesting a mechanism by which cancer cells reacquire properties that are char

45 The molecular mechanism by which cancer-associated fibroblasts (CAFs) confer che

46 We also propose potential mechanisms by which cardiomyopathy-causing mutations may lead to pr

47 irst, we identified a self-feeding mechanism by which CCL1 produced by Treg cells at an autoimmune si

48 target genes have been identified, the basis by which Cdx members impact their transcription is poorl

49 Here, we report a mechanism by which cell density activates the Hippo pathway, which

50 rols septin assembly, and uncover mechanisms by which cells construct defined septin complexes.

51 ranslational modification may be a mechanism by which cells control physiological assembly and preven

52 nuclease complex provides a unique mechanism by which cells ensure chromosome segregation and preserv

53 The ways by which cells respond to complex signal combinations re

54 This may underlie the mechanisms by which cells sense directional physical cues.

55 However, mechanisms by which central serotonin action leads to fat loss rema

56 To identify the mechanism by which ChAT activity is increased, we sought to identi

57 Elucidation of the mechanism by which chemical denaturants unfold proteins is crucial

58 mpaired endothelial function may be pathways by which chronic PTSD increases cardiovascular disease r

59 The mechanisms by which chronic stress promote the development of pancr

60 tively, these findings establish a mechanism by which chronic TNF-alpha signaling orchestrates a func

61 ide a normal resting cell, and the mechanism by which circulating anti-PE antibodies access cellular

62 ittle is known about the molecular mechanism by which CITED2 displaces the tightly bound HIF-1alpha f

63 uctures of the beta2AR reveals the mechanism by which Cmpd-15 modulates agonist binding affinity and

64 We here detail the mechanism by which co-translational signal-peptide cleavage is pre

65 Our results illustrate a mechanism by which cocaine, acting on a key neuromodulation pathwa

66 Together, these results uncover a mechanism by which competitive recruitment of DNA-binding nuclear

67 However the mechanism by which CTCF haploinsufficiency contributes to cancer d

68 echanism of type-B ARR activation, and basis by which cytokinin regulates diverse aspects of growth a

69 The mechanism by which DENV induces lipophagy is unknown.

70 Here we identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signa

71 In this article, we report a new mechanism by which dietary FAs, in particular, saturated FAs (sFAs

72 alid, due to strong intraannual correlations by which different seasons are correlated.

73 a provide novel insights into the mechanisms by which different tissues manage genome stability and p

74 the neural circuits and synaptic mechanisms by which distinct populations of RVM neurons facilitate

75 ine ecosystems, suggesting a novel mechanism by which diversity confers resilience.

76 An enhanced understanding of the mechanisms by which DSA causes allograft injury, and effective stra

77 These data support a novel hypothesis by which dual TCR expression can promote autoimmunity by

78 wever, the cellular and molecular mechanisms by which dysfunction of TDP-43 contributes to disease pa

79 etworks that underlie memory, the mechanisms by which early-life seizures influence them, and the mea

80 ther, these results reveal a novel mechanism by which EBF2 cooperates with a tissue-specific chromati

81 ur findings highlight an important mechanism by which EC contribute to atherogenesis under hyperlipid

82 ence cell expansion; however, the mechanisms by which environmental signals impinge upon microtubule

83 More broadly, this subtlety by which enzymes regulate functions could be used to exp

84 ghlights new avenues for defining mechanisms by which ExPEC strains colonize the mammalian gastrointe

85 Although the mechanism by which extracellular vesicles are internalized is inco

86 However, the mechanisms by which EZH2 is regulated in PCa and CRPC remain elusiv

87 repress expression, however, the mechanisms by which factors find targets remain unclear.

88 escribes the essential immunological process by which feedback repression of sequential DNA rearrange

89 etraction is a novel and complementary means by which fibrinolytic enzymes can reduce thrombus size.

90 ated motor and offer an unexpected mechanism by which filaments of the cytoskeletal network compete f

91 Here, we evaluate two axes by which fishers in Alaska can diversify fishing activit

92 Soil respiration (Rs) is a major pathway by which fixed carbon in the biosphere is returned to th

93 ithin-range cycling is an overlooked process by which fluctuating selection can occur in nature, sugg

94 In an effort to determine the mechanism by which FMRP mediates protein translation and neural ne

95 ort a previously unknown molecular mechanism by which folate regulates trophoblast cell function.

96 ith low-valent cobalt catalysts, new methods by which functionalities may be stitched together become

97 , and reveal a range of molecular mechanisms by which FVIII missense mutations lead to moderate to se

98 , we sought to further elucidate the pathway by which G1 can activate NFAT luciferase.

99 ta therefore support an additional mechanism by which GABABRs are able to modulate fast synaptic inhi

100 However, the mechanism by which Galpha13 signals to actin cytoskeletal reorgani

101 the groundwork for exploration of mechanisms by which gap junction nexus stability modulates intercel

102 a range of bacteria and reveals a mechanism by which gastrointestinal pathogens directly target RHIM

103 its should be expanded to include mechanisms by which genetic variation shapes the environments that

104 GLIS3 in the thyroid gland and the mechanism by which GLIS3 dysfunction causes hypothyroidism are unk

105 Here we investigated mechanisms by which GLP-1 and serotonin interact at the level of th

106 Here we investigated the mechanism by which glucagon and insulin increased FGF21 gene trans

107 r study not only shed light on the mechanism by which glucocorticoid imparts its beneficial effect on

108 Here, we review the mechanisms by which gonadal hormones and sex chromosome complement

109 Type II secretion (T2S) is one means by which Gram-negative pathogens secrete proteins into t

110 ribute to our understanding of the mechanism by which GRKs regulate the function of activated GPCRs.

111 eling were performed to probe the mechanisms by which guanidinium (Gnd(+)) salts influence the stabil

112 However, the mechanism by which H3K4me3 modifiers affect longevity, and whether

113 veloped to determine the transport mechanism by which HCO3(-) ions are secreted at concentrations in

114 ncipally focused on the molecular mechanisms by which hematopoietic cells initiate and maintain innat

115 onal HCO models to investigate the mechanism by which heme E degrees ' modulates oxidase activity.

116 The mechanisms by which hepcidin and hypoferremia modulate host defense

117 Our results suggest a novel mechanism(s) by which HNK exerts its anti-tumor activity through the

118 e brain.SIGNIFICANCE STATEMENT The mechanism by which humans adapt eye movements in response to centr

119 The mechanisms by which immune checkpoint blockade modulates tumor evol

120 ffect cancer development, yet the mechanisms by which immune signaling drives transformation remain u

121 Understanding the mechanisms by which immune-related events in the periphery can infl

122 In summary, we describe a mechanism by which increased cytosolic Ca(2+) negatively regulates

123 ovirus, we highlight the molecular mechanism by which infection with a dsRNA virus results in necropt

124 gh inflammation promotes PAH, the mechanisms by which inflammation and BMPR-II dysfunction conspire t

125 Third, we show that the means by which information is enhanced by locomotion differs b

126 inhibitors could help unveil the mechanisms by which inhibition of poly(ADP-ribose) polymerases (PAR

127 asting, and discuss physiological mechanisms by which intermittent fasting might lead to improved hea

128 However, the mechanism by which IRAK4 activity regulates the production of down

129 tep toward an understanding of the mechanism by which IreB regulates resistance, we initiated a struc

130 biosynthesis of crochelins and the mechanism by which iron may be removed upon import of the holo-sid

131 use-dependent plasticity, but the mechanisms by which it controls vesicle fusion and plasticity are n

132 tion gene doublesex (dsx) and the mechanisms by which it mediates sex-specific development in a horne

133 that of homologous (i.e., non-seam) contacts by which it regularizes the MT lattice.

134 frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis is uncl

135 demonstrate the unique regulatory mechanism by which Iw1 acts to suppress a carboxylesterase-like pr

136 these data outline a new signaling mechanism by which KCa1.1 regulates beta1-integrin function and th

137 brief, our findings reveal a novel mechanism by which KDM3A promotes ovarian CSCs, proliferation and

138 r, our results demonstrate a novel mechanism by which laminins modulate vascular branching and endoth

139 rence are taken as the two broadest criteria by which listeners might meaningfully compare violins.

140 human participants regarding the mechanisms by which loss of estradiol contributes to this vulnerabi

141 , our findings provide additional mechanisms by which lysine methylation signaling impacts on cell fa

142 ecision making is a new behavioral mechanism by which MA rigidly biases choice behavior.

143 we discuss the common and unique mechanisms by which macrophages instruct tissue repair in the liver

144 Our results uncover a novel mechanism by which MALAT1 regulates the activity of p53 through th

145 However, the mechanisms by which manganese (Mn), a common dietary supplement, al

146 The mechanism by which mast cells (MCs) are activated in T cell-mediat

147 ur understanding of processes and mechanisms by which maternal behavior influences the developing hum

148 would gain new insights into the mechanisms by which maternal UBE3A loss derails neurotypical brain

149 The process by which membrane proteins fold involves the burial of s

150 Our findings provide a novel mechanism by which microbial-derived butyrate promotes barrier thr

151 However, the precise mechanisms by which microglia alter the course of AD neuropathology

152 In this study, we examined the mechanism by which Mincle, a C-type lectin receptor, regulates NET

153 cations, but also serves as a potential drug by which modulation of neural glycan biosynthesis and th

154 we actually know little about the processes by which most psoriatic patients maintain what grossly l

155 proteins induced by RBM3 and the mechanisms by which mRNAs encoding cold shock proteins escape cooli

156 The mechanism(s) by which mutant HTT (mHTT) causes disease is unclear.

157 tures and represents an intriguing mechanism by which natural product diversity arises.

158 t the research we describe highlights routes by which natural selection could coopt similar cognitive

159 ibition engaged negative feedback mechanisms by which negative selection and inhibitory receptors res

160 Functioning via a mechanism by which neighbouring iron(ii) sites undergo a spin-stat

161 These results support a molecular mechanism by which Neto2 phosphorylation at Ser-409 helps restrict

162 The mechanisms by which neural circuits perform the computations prescr

163 The mechanisms by which neuroendocrine (NE) cells arises from prostate

164 results provide insight into the mechanisms by which NLRC4 inflammasome activation mediates auto-inf

165 f nitric oxide (NO) are known, the mechanism by which NO modulates corneal wound healing remains uncl

166 The molecular mechanism by which NO operates at the blood-endothelium interface

167 his study, we aimed to define the mechanisms by which noninflammatory SF modulate Th cell responses a

168 However, the mechanisms by which nonmuscle myosin II (NM-II) is recruited to tho

169 However, the sites and neurocircuitry by which NPY decreases SNA are unclear.

170 SD2) neuron activation, identify the circuit by which NTS(HSD2) neurons drive appetite, and uncover a

171 lectively, these findings reveal a mechanism by which nuclear-based changes influence the structure o

172 toneurons, as well as the plastic mechanisms by which one input compensates for the lack of the other

173 However, the mechanisms by which ORMDL3 predisposes to asthma are unclear.

174 One major mechanism by which oxygen regulates cellular function is through t

175 ings identify a previously unknown mechanism by which P. aeruginosa ExoY inhibits the host innate imm

176 t outcomes and to investigate the mechanisms by which p16 may regulate radiosensitivity.

177 in cancer, our findings provide a mechanism by which p53 loss can promote cancer mutagenesis.

178 Together, these studies define mechanisms by which p53 regulates thrombus resolution by increasing

179 P) is a circuit-based synaptic learning rule by which paired activation of entorhinal cortical (EC) a

180 polymers and suggest a segregation mechanism by which ParA-ATP dimers equilibrate to HDRs shown to be

181 s essential insight into multiple mechanisms by which pathogenic mutations interfere with enzyme func

182 itor cells, we describe a sequence of events by which PBX-MEIS facilitates chromatin accessibility of

183 ngs provide evidence for the molecular basis by which phthalates may alter placental function, and th

184 steric sites [alpha(-)-interface containing] by which prototoxins can modulate nAChR function.

185 Here, we report the molecular mechanism by which PS1 modulates betaCTF degradation.

186 cal evidence allow us to propose a mechanism by which Psb28 exerts its protective effect on the RC47

187 dvanced DN and provide a molecular mechanism by which puerarin exerts the anti-oxidative effects in p

188 ico analyses give insight into the mechanism by which radiation modifies glycosylation.

189 s are well known, but the precise mechanisms by which RAS proteins function are less clear.

190 However, the mechanism by which remodellers discriminate between different nucl

191 ut evidence of association and the mechanism by which risk is conferred remain controversial.

192 y and defines a previously unknown mechanism by which S. aureus may influence skin diseases.

193 However, the mechanism by which SagS accomplishes both functions is unknown.

194 These data define a molecular mechanism by which Saureus cells sense the host environment and im

195 ding of the reaction mechanism and the modes by which SBiz imidates interact with various promoters o

196 However, the molecular mechanism by which SERINC5 restricts HIV-1 particle infectivity is

197 identify a previously unsuspected mechanism by which sIgM deficiency aggravates atherosclerosis.

198 h-induced remodeling, the control structures by which signals from distinct mechano-sensors are integ

199 Thus we show a route by which simple hybrid inorganic-organic monomers, such

200 Multiple mechanisms have been identified by which sleep disturbances adversely affect cardiovascu

201 In efforts to uncover the mechanism by which SLFN5 promotes GBM tumorigenesis, we found that

202 This provides a mechanism by which slow-wave activity might bias synapses towards

203 We investigated the mechanisms by which SMAD6 and another inhibitory SMAD (SMAD7) promo

204 evaluated the outcome for possible pathways by which soil characteristics may increase the probabili

205 y neuroscience is to identify the mechanisms by which specific motifs within inter-connected neural c

206 The mechanisms by which sporopollenin is anchored onto microspores and

207 The mechanisms by which SS4 determines granule number and morphology ar

208 is critical to metrology, forming the basis by which standards of time, length, and fundamental cons

209 The GAS M protein, by which strains are differentiated into >220 different

210 The mechanisms by which stressful life events increase the risk of rela

211 begun to illuminate the distinct mechanisms by which structurally, chemically, and functionally dive

212 ction mechanism and suggest plausible routes by which substrates and products enter and leave the act

213 The mechanism by which Suc affects the circadian oscillator in a GI-de

214 ontotemporal dementia, though the mechanisms by which such expansions cause neurodegeneration are poo

215 The mechanism by which such peptides emerge from linear precursor prot

216 hydratases (NHases), and yet the mechanisms by which sulfurs are oxidized by these enzymes are unkno

217 These results support a scenario by which T cell-derived microvesicles act as intercellul

218 ional in that it showed not only a mechanism by which T cells become pathogenic before entering the C

219 stinal mucosa and investigated the mechanism by which T-UCR uc.173 regulates epithelial renewal.

220 nduction of T cell responses, the mechanisms by which targeting improves Ab responses are poorly unde

221 The mechanisms by which tau organizes microtubule networks remain poorl

222 75) provide new insights into the mechanisms by which temporal and spatial regulators are coordinated

223 disease, and also revealed novel mechanisms by which TGFbeta signals are transduced.

224 , our results reveal the molecular mechanism by which TH functions during red blood cell formation, r

225 The precise mechanism by which the bacterial SRP receptor, FtsY, interacts wit

226 This new insight provides a framework by which the behavior of spinel can be more accurately m

227 at CRP K100 acetylation could be a mechanism by which the cell downwardly tunes CRP-dependent Class I

228 Here, we investigated the mechanism by which the Chlamydia-containing vacuole, termed the in

229 alian cell culture, we elucidate a mechanism by which the coincidence of PI(4,5)P2 and PI(3)P in a cu

230 The mechanisms by which the constraint of a hard pericarp determines ge

231 The mechanisms by which the deep ocean circulation changed, however, ar

232 Next, we identified the mechanism by which the engulfment of erythrocytes with exposed pho

233 This work provides a physical basis by which the flow rate and the voltage can be chosen for

234 ly-processive and largely continuous process by which the genome is duplicated.

235 n together, our work reveals the specificity by which the handling by NCLX of calcium exchange can ma

236 However, the mechanisms by which the human brain updates specific goals on the f

237 The exact extent, by which the hydrologic cycle in the Neotropics was affe

238 ore, cathelicidins provide a novel mechanism by which the immune system can discriminate between viab

239 cal models to study two different mechanisms by which the immune system can select for broadly neutra

240 Thus, the means by which the interphase expression pattern is transduced

241 enced CD8(+) T cells and provide a mechanism by which the presence of T1-IFN potentiates diabetogenic

242 line hypothesis and elucidation of the means by which the protein might dictate an alternative oxo po

243 We present a method by which the spectral intensity of an ultrafast laser pu

244 ions in the network can control the dynamics by which the system reaches limit cycle oscillations, th

245 s, but the cellular and molecular mechanisms by which their therapeutic action is initiated are poorl

246 embrane vesicle extrusion are possible means by which these canonically intracellular components migh

247 necessary to further explore the mechanisms by which these genes affect adipocyte biology and how th

248 dentified; however, the molecular mechanisms by which these GFs regulate the survival, proliferation.

249 developing embryos; however, the mechanisms by which these gradients are interpreted remain elusive.

250 We review the mechanisms by which these gut bacteria, fungi, and viruses mediate

251 aimed to define the underlying mechanism(s) by which these LDLR mutations affect LDL metabolism and

252 The molecular mechanisms by which these ligands affect the exhausted states of im

253 lial barrier and to elucidate the mechanisms by which these miRNAs modify cervical epithelial cell fu

254 around the world [1]; however, the mechanism by which these organisms produce the mineral is poorly u

255 Our findings provide plausible mechanisms by which these sequences could alter RNA granule propert

256 The MCU complex is the major pathway by which these signals are integrated in mitochondria.

257 e of inflammatory signals and the mechanisms by which these signals regulate the disruption of avascu

258 ity, and characterized the mechanistic basis by which these suppressors alleviated Deltahda cold sens

259 However, their functions and the mechanisms by which they act are not fully understood.

260 overning their abundance, and the mechanisms by which they affect the function of neural circuits are

261 We report here a mechanism by which they are activated in cancer cells, involving r

262 tionship to other proteins and the processes by which they are assembled to create the exosporium are

263 these glycans in planta, and the mechanisms by which they are depolymerized in microbial ecosystems.

264 oligomeric precursors and of the mechanisms by which they are formed and proliferate to generate cel

265 ting and to determine the molecular pathways by which they contributed to muscle dysfunction.

266 formation, and, consequently, the mechanism by which they form.

267 ctivity, but the precise molecular mechanism by which they function is still poorly understood.

268 emistry to describe the molecular mechanisms by which they function.

269 s following major surgery, but the mechanism by which they increase cost and the categories of care t

270 hippocampal neurogenesis, but the mechanisms by which they increase neurogenesis and modulate behavio

271 The mechanisms by which they perform this function have been hard to de

272 It has been speculated that the mechanism by which thick filament length is controlled involves th

273 blockade of IL-21 to dissect the mechanisms by which this cytokine promotes autoimmunity in murine l

274 ever, little is known about the mechanism(s) by which this feedback occurs.

275 ood when consumed together and the mechanism by which this might occur.We compared the acute effect o

276 The mechanism by which this occurs is unknown.

277 is and Neisseria gonorrhoeae, the mechanisms by which this pathogen elicits inflammation, causes cell

278 hat undergo phase separation, the mechanisms by which this phase transition occurs, and the resultant

279 However, the mechanistic pathway by which this reaction proceeds has remained unclear for

280 ression patterns to determine the mechanisms by which TL1A regulates cytokine production, and whether

281 must shift to determining the best strategy by which to target LSCs, with their well-documented hete

282 New research reveals the genetic basis by which tobacco plants control the temporal emission of

283 imulus paradigm to understand the mechanisms by which top-down processes (expectation and memory) and

284 obalization of medical education-the process by which trainees in any region gain access to internati

285 However, the mechanism by which transcription termination is achieved is not un

286 We report novel mechanisms by which TRMs regulate T cell activities at tissue sites

287 The mechanism by which TRP channels participate in pruritogen-induced

288 r of receptor-ligand bonds regulate the rate by which tumor cells tether, roll, and adhere to vascula

289 o cooperative structural-ordering processes, by which ultrafast crystal growth becomes possible.

290 We also identify a PKG-dependent mechanism by which valsartan/sacubitril, a combination drug recent

291 xts is required to understand the mechanisms by which variation in non-coding genetic sequences contr

292 iment reveals a surprisingly complex pathway by which very different types of defects may be related

293 Understanding the molecular mechanism(s) by which viral proteins such as HIV-1 Transactivator of

294 Here, we have examined the host pathways by which vMIA traffics from the ER to mitochondria and c

295 Still, CsMPs provide a mechanism by which volatile and low-volatility radionuclides such

296 We introduce a method by which we can examine the relationship between our mea

297 The mechanisms by which WNV enters the central nervous system (CNS) and

298 re two distinct but complementary mechanisms by which XPC influences gene regulation by coordinating

299 er, our study not only reveals the mechanism by which YAP reprograms glucose metabolism, but also hig

300 family and ZEB1, but the precise mechanisms by which ZEB1-dependent EMT promotes malignancy remain l