ライフサイエンスコーパス: bystander effect

1 ced the transfer of lacZ (media transferable bystander effect).

2 ical conjugation of the drug to the peptide (bystander effect).

3 als from irradiated cells (radiation-induced bystander effects).

4 of tumor infected), indicating a significant bystander effect.

5 n proposed to regulate the radiation-induced bystander effect.

6 ouracil (5-FU), which exhibited considerable bystander effect.

7 e effective than IGF-Ir/950st because of its bystander effect.

8 s of B16 tumor cells, indicative of a potent bystander effect.

9 y, the TK system exhibited a lower degree of bystander effect.

10 is in the tumors, likely contributing to the bystander effect.

11 a secreted factor may also contribute to the bystander effect.

12 s reduced throughout the veins, confirming a bystander effect.

13 ore sensitive to CMDA and could mount a good bystander effect.

14 is secreted extracellularly, resulting in a bystander effect.

15 lar communication (GJIC) to produce a strong bystander effect.

16 ed cells is consistent with the absence of a bystander effect.

17 cell growth by 50%, and the magnitude of the bystander effect.

18 ent with GCV, which was mediated by a strong bystander effect.

19 h do not express HSV-tk, has been called the bystander effect.

20 with directly damaged cells by means of the bystander effect.

21 away from consideration of this finding as a bystander effect.

22 RGC death through the gap junction-mediated bystander effect.

23 rapeutic targets for the exploitation of the bystander effect.

24 es COX-2 activity, significantly reduced the bystander effect.

25 ll as to prevent deleterious tissue-damaging bystander effects.

26 t therapeutic gene expression with resultant bystander effects.

27 through a combination of cross-reactive and bystander effects.

28 s corresponds to genetic defects rather than bystander effects.

29 t the transfer of the TRAIL gene resulted in bystander effects.

30 igher mutant yield than expected assuming no bystander effects.

31 hromosome instability via macrophage-induced bystander effects.

32 rgeting of noncancer cells in the tumor, and bystander effects.

33 al (i.e., cancerous or senescent) may induce bystander effects.

34 fic molecular mechanism for these persistent bystander effects.

35 dual-chamber coculture system for detecting bystander effects.

36 ll response was highly specific with minimal bystander effects.

37 e mechanisms may be involved in transmitting bystander effects.

38 n normal cells, thus exerting an anti-tumor "bystander" effect.

39 ptosis to nearby cells is referred to as the bystander effect, a process that is integral to tissue h

40 t occur along with the decreased TP53/CDKN1A bystander effect also would expectedly favor enhanced ce

41 ctors that directly or indirectly leads to a bystander effect and a second caspase-2-dependent proces

42 tic efficiency of VSV by generating a strong bystander effect and by contributing to the activation o

43 H2AX phosphorylation is an early step in the bystander effect and that the DNA DSBs underlying gamma-

44 this study, we investigated the E1A-mediated bystander effect and the mechanisms that may be associat

45 role in the regulation of radiation-induced bystander effects and that mitochondria-dependent NF-kap

46 secreted by normal cells in mediating this 'bystander effect', and document that normal cells induce

47 propagation of genomic instability through a bystander effect, and offers a novel theory for the role

48 ch are based on molecular mimicry and/or the bystander effect, and suggests that the autoimmune proce

49 However, adaptive responses, bystander effects, and death-inducing effect may influen

50 ree cancer cell lines for 5FC sensitization, bystander effects, and formation of 5-fluorouracil metab

51 ecretable form that enhances apoptosis via a bystander effect; and (b) an ER-targeted TRAIL that is r

52 Therefore, the thermal bystander effect appears to be an active process in whic

53 n microdosimetric estimation in support of a bystander effect appears to be consistent, direct proof

54 The mechanisms underlying the bystander effect are obscure, but genomic instability su

55 Bystander effects are nontargeted effects observed in ce

56 CD/5-FC treatment strategy by increasing the bystander effect as well as the efficacy of radiotherapy

57 t extensive apoptosis without evidence for a bystander effect at the maximal viral dose (i.e., 2.5 x

58 We coin this phenomenon "active thermal bystander effect" (ATBE).

59 Danio rerio, for our studies on the in vivo bystander effect between embryos irradiated with high-do

60 diated neighboring cells, referred to as the bystander effect (BSE), is not well understood in terms

61 ing about how inflammatory cytokines mediate bystander effects, but questions in this area are import

62 reted MDA-7/IL-24 protein induces antitumor "bystander" effects by promoting its own expression.

63 insic antiproliferation activity, can cause 'bystander effect' by inducing export of growth suppressi

64 bsence of AIPL1 could be due to an indirect 'bystander effect' caused by rod photoreceptor death or a

65 uced genomic instability, death-inducing and bystander effects, clastogenic factors and transgenerati

66 s in nonirradiated cells (death-inducing and bystander effects, clastogenic factors) and perpetuate g

67 Compound (+/-)-7also exhibited good bystander effect compared to 5-aziridinyl-2,4-dinitroben

68 cant reduction in IC(50) values and improved bystander effect compared with wild-type bCD.

69 ugh we did not observe an indirect cytotoxic bystander effect conveyed to nontransduced tumor cells i

70 We also report data showing that the bystander effect could be successfully induced in naive

71 Possible low-dose IR-induced bystander effects could impact our evaluation of human h

72 To distinguish bystander effects, equal erythemal doses of two UVB wave

73 s enzyme/prodrug strategy exhibited a potent bystander effect, even when <10% of the cells were trans

74 viduals do not harbor virus, and therefore a bystander effect has been postulated to mediate apoptosi

75 Although radiation-induced bystander effects have been demonstrated in a number of

76 proximity to cells that are." Although these bystander effects have been demonstrated with a variety

77 carcinoma and that apoptosis and significant bystander effects have been identified as the mechanisms

78 Macrophage-induced bystander effects have been implicated as an important m

79 Bystander effects have been observed largely by using si

80 Although radiation-induced bystander effects have been well described over the past

81 as radiation-induced genomic instability and bystander effects have challenged this dogma.

82 ich lower nitric oxide levels, prevented the bystander effect in both protocols.

83 nduce GCV sensitivity and test the potential bystander effect in established pancreatic carcinoma cel

84 e, which blocks gap-junctions, prevented the bystander effect in mixing but not in media transfer pro

85 signal into the medium, which could induce a bystander effect in partnered naive embryos sharing the

86 on of the HSV-TK gene elicited a significant bystander effect in the presence of GCV.

87 cally modified to express HSV-TK, and on the bystander effect in which unmodified target cells are ki

88 w that X-irradiation induces medium-mediated bystander effects in AGO1522 normal human fibroblasts.

89 cells seemed to be involved in tumor-induced bystander effects in animals because CCL2-null tumor-bea

90 g cells, TGF-beta and NO were found to mimic bystander effects in cell populations lacking DNA synthe

91 alpha-particle microbeam irradiation-induced bystander effects in human tissue models, which preserve

92 this model is attractive for characterizing bystander effects in retinal degeneration.

93 proved toxicity similar to CA4 and displayed bystander effects in vitro.

94 ion in the tumors, indicative of significant bystander effects in vivo.

95 ults define a pathway for macrophage-induced bystander effects in which TNF-alpha triggers TNFRSF1b r

96 The "radiation-induced bystander effect," in which irradiated cells can induce

97 Pronounced "bystander effects" including neighboring cells were note

98 d embryos was unlikely to be involved in the bystander effect induced through the IECM because of the

99 F-alpha acts as a diffusible mediator of the bystander effects induced by macrophages, an effect caus

100 We further revealed that this bystander effect (induced through IECM) was rapidly abol

101 We further demonstrated that this bystander effect (induced through partnering) could be s

102 ription predisposes non-replicating cells to bystander effect-induced DNA DSBs, we examined two types

103 The radiation-induced bystander effect is a prime example of this effect, wher

104 The radiation-induced bystander effect is defined as "the induction of biologi

105 el stochastic model of the radiation-induced bystander effect is developed that takes account of spat

106 underlying mechanism(s) of radiation-induced bystander effect is still unclear.

107 The importance of bystander effects is becoming more appreciated, as studi

108 -1 TK for metabolism and sensitivity to GCV, bystander effect killing and induction of apoptosis.

109 entrations, cell sensitivity to the drug and bystander effect killing were diminished but still effec

110 ro results suggest that the observed in vivo bystander effect leading to tumor cell growth inhibition

111 infected somatic neurons would thus permit a bystander effect, leading to activation of the sensory a

112 ansfer of E1A into tumors, suggesting that a bystander effect may also be associated with E1A.

113 n-induced genomic instability and untargeted bystander effects may reflect inter-related aspects of i

114 Non-targeted (bystander) effects may influence these cells' response t

115 of a significant radiation quality-dependent bystander effect, measured as chromosomal damage in the

116 cell mismatch, epitope spread or drift, the bystander effect, molecular mimicry, anti-idiotype theor

117 e findings also offer an explanation for the bystander effect observed in the LNs of AIDS patients, w

118 A strong bystander effect occurred because of methylselenol relea

119 ute negative, yet proliferation-independent, bystander effect of irradiated recipients on transplante

120 ion of the RUNX3 canonical CGI promoter is a bystander effect of oncogenic immortalization and not li

121 signaling may play an important role in the bystander effect of radiation.

122 g cells showed the proapoptotic activity and bystander effect of the TRAIL gene to be not transferabl

123 To further demonstrate the bystander effect of the TRAIL gene, we constructed plasm

124 This bystander effect of viral infection on activated T cells

125 The low IC(50), high selectivity, and good bystander effects of nitrobenzylphosphoramide mustards i

126 n of most human lymphomas, presumably due to bystander effects of the immunoglobulin gene remodeling

127 No bystander effect on CD34(+) cells was observed.

128 f type I NKT cell response, suggesting their bystander effect on gammadelta T cells.

129 found that the E1A transfectants exhibited a bystander effect on inhibition of tumor growth.

130 binant adenoviral vector and elicit a potent bystander effect on neighboring tumor cells.

131 infected with AdCMV.CD exhibited a profound bystander effect on the growth of neighboring cells, whi

132 recipients pose a proliferation-independent bystander effect on transplanted HSCs is unclear.

133 r, our results suggested that E1A mediates a bystander effect on tumor suppression by inhibiting angi

134 ting from ongoing HIV replication leading to bystander effects on B cells.

135 It is known that ionizing radiation exerts "bystander effects" on nontargeted cells and that HSCs tr

136 adiation-induced genomic instability through bystander effects or increased mutation rates in cell pr

137 RKO cells do not exhibit adaptive response, bystander effect, or death-inducing effect, as measured

138 The bystander effect, originating from cells irradiated in v

139 ing the limitations imposed by the prodrugs' bystander effects, our findings show that yCD:UPRT/5-FC

140 ed sarcoma cells in vitro through direct and bystander effects (P < 0.01).

141 This model suggests that these so-called "bystander" effects play a significant role in determinin

142 Radiation-induced bystander effects refer to biologic responses in cells t

143 The term "bystander effects" refers to changes in naive cells shar

144 The radiation-induced bystander effect (RIBE) increases the probability of cel

145 The radiation-induced bystander effect (RIBE) refers to a unique process in wh

146 The bystander effect seems dependent on the production of re

147 These findings may explain, in part, the bystander effect seen with p53 tumor suppressor gene the

148 should be effective in vivo and enhance the bystander effect, suggesting that FMG-based gene therapy

149 but were insufficient to explain the entire bystander effect, suggesting the recruitment of other me

150 the results obtained are a consequence of a bystander effect that is generated in vivo by factor(s)

151 issue culture models and determine whether a bystander effect that is initiated by the in vivo decay

152 to tumor cell death and to the activation of bystander effects that harness the immune system against

153 nt prodrug GCV conversion and activation for bystander effects that kill the surrounding untransduced

154 nt prodrug GCV conversion and activation for bystander effects that killed many surrounding untransdu

155 The "bystander effects" that lead to enormous reductions in t

156 ty, as do adjacent non-irradiated cells (the bystander effect); the importance to carcinogenesis rema

157 In the second, radiation-induced bystander effects, they arise in cells that receive no r

158 Like the increased intracellular ROS bystander effect, this "decreased TP53/CDKN1A response"

159 mechanism by which paclitaxel induces toxic bystander effect through generation of extracellular H(2

160 to MHC II(lo) macrophages and were able by a bystander effect to induce the differentiation of the en

161 ms has allowed nontargeted responses such as bystander effects to be more carefully analysed.

162 This finding links the macrophage-induced bystander effects to colorectal carcinogenesis.

163 cific effects or, alternatively, that induce bystander effects to potentially increase the efficacy o

164 en more formally examined thresholds for the bystander effect, using both MuLv and lentiviral vectori

165 Bystander effect was also observed on the tumors generat

166 This cytotoxic bystander effect was also observed with other microtubul

167 ter, which agreed with the proposal that the bystander effect was an on/off response with a threshold

168 This toxic bystander effect was enhanced by CuZnSOD that converts O

169 The role of MAC in bystander effects was then assessed in mouse embryonic f

170 that DD1-mediated apoptosis also leads to a "bystander effect." We found that within 5 h of DD1 expre

171 esent study, ionizing radiation (IR)-induced bystander effects were investigated in two lung cancer c

172 disulfide bond were capable of exerting the bystander effect whereas equally potent conjugates linke

173 Bystander effects, whereby cells that are not directly e

174 echanism for the production of damage via a 'bystander' effect which may contribute to radiation-indu

175 to selective killing of malignant cells with bystander effect, which suggests that the TRAIL gene cou

176 emonstrate, unequivocally, the presence of a bystander effect with many biological end points.

177 tacks both tumor and stroma cells through a "bystander effect" without selectively deleting target-pr

178 These bystander effects would tend to cause further deteriorat